verapamil and flecainide

verapamil has been researched along with flecainide in 89 studies

Research

Studies (89)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (16.85)	18.7374
1990's	27 (30.34)	18.2507
2000's	23 (25.84)	29.6817
2010's	18 (20.22)	24.3611
2020's	6 (6.74)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Arieff, Z; Bardien-Kruger, S; Brink, P; Chandy, KG; Corfield, V; Wulff, H	1
Keserü, GM	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Sen, S; Sinha, N	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Buss, J; Heene, DL; Lasserre, JJ	1
Doran, TC; Lensmeyer, GL; Wiebe, DA	1
Camm, AJ; Gill, JS; Mehta, D; Ward, DE	1
Kingma, JH; Suttorp, MJ	1
Bauman, JL; Ezri, M; Nazari, J; Tworek, DA	1
Sheiner, LB; Verotta, D	1
Shinebourne, EA; Till, JA	1
Balderston, SM; Johnson, KE; Reiter, MJ	1
Kastrati, A; Kondili, A; Popa, Y	1
Finzi, A; Guenzati, G; Potenza, S	1
Bettini, R; Cozzi, F; Dal Forno, P; Furlanello, F	1
Keefe, DL; Miura, D; Somberg, JC	1
Kingma, JH; Lie-A-Huen, L; Mast, EG; Suttorp, MJ	1
Camm, AJ; Parker, DJ; Wafa, SS; Ward, DE	1
Berry, DA; Ekholm, BP; Finley, D; Holtzman, JL; Kvam, DC; McQuinn, RL; Miller, AM; Mottonen, L	1
Bechi, S; Cordoni, M; Franchini, C; Mazza, F; Micheli, G; Scalzini, A	1
Hoffmeister, HM; Krämer, B; Pflug, A; Seipel, L	1
Somberg, J	1
Morganroth, J; Nestico, PF	1
Huang, SK; Marcus, FI	1
Campbell, RW; Wren, C	1
Bald, R; Gembruch, U; Hansmann, M	1
Hillis, WS; Whiting, B	1
Somberg, JC	1
Duff, HJ; Oates, JA; Roden, DM; Woosley, RL	1
Ikeda, N; Josephson, MA; Kannan, R; Nademanee, K; Singh, BN; Venkatesh, N	1
Haruno, A; Hashimoto, K	1
Hamer, AW; Hunt, VD; Strathmore, N; Vohra, JK	1
Chalmers, JP; McRitchie, RJ; Roberts-Thomson, P; Twidale, N	1
Barranco, F; Guerrero, M; Rodriguez, J; Sanchez, M	1
Lüderitz, B; Manz, M	1
Hayashi, Y; Kamibayashi, T; Kawabata, K; Sumikawa, K; Takada, K; Yamatodani, A; Yoshiya, I	1
Alberola, A; Burguera, MA; Chorro, FJ; Lopez-Merino, V; Quesada, A; Sanchis, J; Such, L	1
Coumel, P; Dorian, P; Hohnloser, SH; Maser, MJ; Naccarelli, GV	1
Busi, G; Matteucci, C	1
Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ	1
Casanova, JM; De Micheli, A; Iturralde, P; Medrano, GA	1
Akimoto, S; Hanada, K; Hashiguchi, M; Mitsui, K; Ogata, H	1
Akimoto, S; Hanada, K; Mihara, K; Mitsui, K; Ogata, H	1
D'Andrea, A; Ducceschi, V; Iacono, A; Liccardo, B; Santangelo, L; Sarubbi, B	1
Sharland, GK; Simpson, JM	1
Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S	1
Aupetit, JF; Bui-Xuan, B; Frassati, D; Kioueh, I; Loufoua, J; Timour, Q	1
Feng, JL; Nattel, S; Wang, Z; Yue, L	1
Cánoves, J; Chorro, FJ; Guerrero, J; López-Merino, V; Mainar, L; Sanchis, J; Such, L	1
Dell'Orfano, JT; Luck, JC; Naccarelli, GV; Patel, HM; Wolbrette, DL	1
Iwamoto, M; Kobayashi, H; Niimura, I; Nishizawa, T; Sakon, T; Shibata, T; Takigiku, K; Yasui, K; Yokoyama, U	1
Herd, A; Minish, T	1
Alfano, F; Campana, A; Canciello, M; De Fabrizio, G; De Matteis, C; De Pasquale, M; De Simone, A; Di Mauro, M; Manzo, M; Sabino, L; Stabile, G; Turco, P; Vitale, DF	1
Crijns, HJ; Merckx, KL; Tieleman, RG	1
Freestone, B; Lip, GY	2
Antzelevitch, C; Fish, JM	1
Atalik, KE; Dogan, N; Sahin, AS	1
Lip, GY	1
Hayashi, Y; Ito, I; Iwasaki, M; Kamibayashi, T; Kawai, Y; Mashimo, T; Takada, K; Yamatodani, A	1
Bittner, A; Dechering, DG; Eckardt, L; Köbe, J; Kotthoff, S; Mönnig, G; Muszynski, A; Pott, C; Reinke, F; Schulze-Bahr, E; Wasmer, K; Zellerhoff, S	1
Denjoy, I; Guicheney, P; Leenhardt, A	1
Chao, SP; Chen, H; Jiang, XJ; Ren, JH; Wang, SM; Xu, L; Zhang, D	1
Cao, J; Hu, N; Su, K; Wang, P; Wang, T; Wu, J	1
Janson, CM; Poelzing, S; Shah, MJ	1
Bergenholm, L; Chappell, MJ; Collins, T; Evans, ND; Mettetal, J; Parkinson, J	1
Hinoi, E; Miyawaki, I; Tsubouchi, T; Watanabe, K; Yamada, T	1
Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B	1
Fletcher, S; Gharanei, M; James, RS; Maddock, H; Wallis, R	1
Adiyaman, A; Beukema, RJ; de Jong, JSSG; Delnoy, PPHM; Elvan, A; Haanschoten, DM; Khan, M; Otten, AM; Ramdat Misier, AR; Smit, JJJ; Szili-Torok, T; Ter Bekke, RMA; Vernooy, K	1
Bertels, RA; Blom, NA; Filippini, LH; Kammeraad, JAE; Knobbe, I; Kuipers, IM; Zeelenberg, AM	1
Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H	1
Bove, T; Cilenti, F; Copetti, R; Cristiani, L; Guglielmo, N; Orso, D; Santangelo, S	1
Charrabi, A; Chen, S; Cheung, JW; Colombani, S; Evans, T; Jaffré, F; Lacampagne, A; Lerman, BB; Marks, AR; Meli, AC; Pasquié, JL; Reiken, S; Sittenfeld, LR; Sleiman, Y	1

Reviews

17 review(s) available for verapamil and flecainide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interference by antiarrhythmic agents with function of electrical cardiac devices. Clinical pharmacy, 1992, Volume: 11, Issue:1 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Death, Sudden, Cardiac; Digoxin; Drug Interactions; Electric Countershock; Female; Flecainide; Humans; Male; Middle Aged; Pacemaker, Artificial; Prostheses and Implants; Verapamil; Warfarin	1992
Supraventricular tachycardia: diagnosis and current acute management. Archives of disease in childhood, 1991, Volume: 66, Issue:5 Topics: Adenosine; Electric Countershock; Electrocardiography; Flecainide; Humans; Infant; Infant, Newborn; Prognosis; Tachycardia, Supraventricular; Verapamil	1991
The treatment of ventricular rhythm disturbances. American heart journal, 1986, Volume: 111, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil	1986
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Annals of the New York Academy of Sciences, 1984, Volume: 432 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans; Drug Interactions; Flecainide; Heart; Hemodynamics; Humans; In Vitro Techniques; Myocardial Contraction; Piperidines; Verapamil	1984
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy. European heart journal, 1993, Volume: 14 Suppl E Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil	1993
Atrial fibrillation: what are the effects of drug therapy on the effectiveness and complications of electrical cardioversion? The Canadian journal of cardiology, 1998, Volume: 14, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Digoxin; Electric Countershock; Flecainide; Humans; Procainamide; Quinidine; Verapamil	1998
Cost-effective management of acute atrial fibrillation: role of rate control, spontaneous conversion, medical and direct current cardioversion, transesophageal echocardiography, and antiembolic therapy. The American journal of cardiology, 2000, May-25, Volume: 85, Issue:10A Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Echocardiography, Transesophageal; Electric Countershock; Flecainide; Humans; Procainamide; Propafenone; Quinidine; Sotalol; Verapamil	2000
Atrial fibrillation (acute). Clinical evidence, 2003, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Timolol; Verapamil	2003
Atrial fibrillation (acute). Clinical evidence, 2004, Issue:11 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil	2004
Atrial fibrillation (recent onset). Clinical evidence, 2005, Issue:14 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil	2005
Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium Channel Blockers; Child; Death, Sudden, Cardiac; Defibrillators, Implantable; Drug Therapy, Combination; Electrocardiography; Flecainide; Humans; Male; Mutation; Ryanodine Receptor Calcium Release Channel; Tachycardia, Ventricular; Treatment Outcome; Verapamil	2011
Catecholaminergic polymorphic ventricular tachycardia. Circulation. Arrhythmia and electrophysiology, 2012, Volume: 5, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calsequestrin; Defibrillators, Implantable; Electrocardiography; Flecainide; Humans; Mutation; Phenotype; Ryanodine Receptor Calcium Release Channel; Sympathectomy; Tachycardia, Ventricular; Verapamil	2012
Bayesian Network Meta-analysis of Randomized Controlled Trials on the Efficacy of Antiarrhythmics in the Pharmacological Cardioversion of Paroxysmal Atrial Fibrillation. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2023, Volume: 23, Issue:4 Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Flecainide; Humans; Network Meta-Analysis; Quinidine; Randomized Controlled Trials as Topic; Ranolazine; Systematic Reviews as Topic; Verapamil	2023

Trials

11 trial(s) available for verapamil and flecainide

Article	Year
Acute pharmacologic conversion of atrial fibrillation and flutter: the role of flecainide, propafenone, and verapamil. The American journal of cardiology, 1992, Aug-20, Volume: 70, Issue:5 Topics: Atrial Fibrillation; Atrial Flutter; Drug Evaluation; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Single-Blind Method; Time Factors; Verapamil	1992
Comparative evaluation of verapamil, flecainide and propafenone for the acute conversion of atrial fibrillation to sinus rhythm. Wiener klinische Wochenschrift, 1990, Sep-14, Volume: 102, Issue:17 Topics: Adult; Aged; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Propafenone; Verapamil	1990
Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. The American journal of cardiology, 1989, Mar-15, Volume: 63, Issue:11 Topics: Adult; Aged; Atrial Fibrillation; Atrial Flutter; Clinical Trials as Topic; Female; Flecainide; Heart Conduction System; Humans; Male; Middle Aged; Random Allocation; Time Factors; Verapamil	1989
Efficacy of flecainide acetate for atrial arrhythmias following coronary artery bypass grafting. The American journal of cardiology, 1989, May-01, Volume: 63, Issue:15 Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Artery Bypass; Digoxin; Drug Therapy, Combination; Female; Flecainide; Hemodynamics; Humans; Male; Middle Aged; Random Allocation; Verapamil	1989
Selection of an antiarrhythmic drug for a sudden-death-prevention trial. American heart journal, 1982, Volume: 103, Issue:4 Pt 2 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil	1982
Oral flecainide, sotalol, and verapamil for the termination of paroxysmal supraventricular tachycardia. Pacing and clinical electrophysiology : PACE, 1993, Volume: 16, Issue:7 Pt 1 Topics: Administration, Oral; Adult; Cardiac Pacing, Artificial; Female; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil	1993
Efficacy of flecainide in patients with supraventricular arrhythmias and respiratory insufficiency. Intensive care medicine, 1994, Volume: 20, Issue:1 Topics: Acute Disease; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Chi-Square Distribution; Electrocardiography; Female; Flecainide; Humans; Infusions, Intravenous; Lung Diseases, Obstructive; Male; Middle Aged; Respiratory Insufficiency; Verapamil	1994
A randomized comparison of flecainide versus verapamil in paroxysmal supraventricular tachycardia. The Flecainide Multicenter Investigators Group. The American journal of cardiology, 1996, Jan-25, Volume: 77, Issue:3 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Flecainide; Humans; Life Tables; Male; Middle Aged; Recurrence; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil	1996
VErapamil plus antiarrhythmic drugs reduce atrial fibrillation recurrences after an electrical cardioversion (VEPARAF Study). European heart journal, 2003, Volume: 24, Issue:15 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Disease-Free Survival; Drug Therapy, Combination; Electric Countershock; Female; Flecainide; Humans; Male; Middle Aged; Secondary Prevention; Treatment Outcome; Verapamil	2003
Predicting QRS and PR interval prolongations in humans using nonclinical data. British journal of pharmacology, 2017, Volume: 174, Issue:19 Topics: Animals; Anti-Arrhythmia Agents; Azabicyclo Compounds; Carbamates; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Flecainide; Guinea Pigs; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Models, Biological; Quinidine; Verapamil	2017
Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide). Cardiology, 2020, Volume: 145, Issue:12 Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Catheter Ablation; Flecainide; Humans; Prospective Studies; Quality of Life; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil	2020

Other Studies

61 other study(ies) available for verapamil and flecainide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). European journal of human genetics : EJHG, 2002, Volume: 10, Issue:1 Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; COS Cells; DNA; Heart Block; Heart Diseases; Humans; Mice; Molecular Sequence Data; Potassium Channels; Potassium Channels, Voltage-Gated; Shaker Superfamily of Potassium Channels; Trinucleotide Repeats	2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Asystole and cardiogenic shock due to combined treatment with verapamil and flecainide. Lancet (London, England), 1992, Aug-29, Volume: 340, Issue:8818 Topics: Aged; Drug Therapy, Combination; Flecainide; Heart Arrest; Humans; Male; Shock, Cardiogenic; Verapamil	1992
Application of the Empore solid-phase extraction membrane to the isolation of drugs from blood: II. Mexiletine and flecainide. Therapeutic drug monitoring, 1992, Volume: 14, Issue:5 Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flecainide; Humans; Membranes, Artificial; Mexiletine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Verapamil	1992
Efficacy of flecainide, sotalol, and verapamil in the treatment of right ventricular tachycardia in patients without overt cardiac abnormality. British heart journal, 1992, Volume: 68, Issue:4 Topics: Adult; Aged; Electric Stimulation; Exercise Test; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil	1992
Semiparametric analysis of non-steady-state pharmacodynamic data. Journal of pharmacokinetics and biopharmaceutics, 1991, Volume: 19, Issue:6 Topics: Computer Simulation; Flecainide; Humans; Hydroxyzine; Metabolic Clearance Rate; Models, Statistical; Pharmacokinetics; Stochastic Processes; Verapamil	1991
Electrophysiologic evaluation of cardiovascular agents in the isolated intact rabbit heart. Journal of pharmacological methods, 1991, Volume: 25, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Electrodes; Flecainide; Heart; Heart Conduction System; In Vitro Techniques; Perfusion; Rabbits; Refractory Period, Electrophysiological; Verapamil	1991
[His bundle block 2:1 during paroxysmal supraventricular tachycardia involving an occult accessory atrio-His pathway]. Giornale italiano di cardiologia, 1990, Volume: 20, Issue:12 Topics: Bundle of His; Electrocardiography; Female; Flecainide; Heart Block; Heart Conduction System; Humans; Middle Aged; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Time Factors; Verapamil	1990
Arrhythmogenic effects of antiarrhythmic drugs. Cardiologia (Rome, Italy), 1990, Volume: 35, Issue:1 Suppl Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Risk Factors; Sotalol; Tachycardia; Verapamil	1990
The pharmacodynamic and pharmacokinetic interaction between single doses of flecainide acetate and verapamil: effects on cardiac function and drug clearance. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:1 Topics: Administration, Oral; Adult; Drug Interactions; Echocardiography; Electrocardiography; Flecainide; Hemodynamics; Humans; Male; Metabolic Clearance Rate; Verapamil	1989
[Supraventricular tachyarrhythmia of recent onset in the absence of documented cardiac pathology: different therapeutic approaches]. Cardiologia (Rome, Italy), 1989, Volume: 34, Issue:4 Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Electric Countershock; Female; Flecainide; Humans; Male; Middle Aged; Retrospective Studies; Tachycardia, Paroxysmal; Verapamil	1989
Circulatory and myocardial effects of different sodium antagonistic drugs in comparison to the calcium antagonist verapamil. Arzneimittel-Forschung, 1989, Volume: 39, Issue:11 Topics: Animals; Cardiac Output; Disopyramide; Flecainide; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Quinidine; Rats; Rats, Inbred Strains; Sodium; Verapamil	1989
His bundle tachycardia--arrhythmogenic and antiarrhythmic effects of therapy. European heart journal, 1987, Volume: 8, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Bundle of His; Electrocardiography; Flecainide; Humans; Infant, Newborn; Male; Tachycardia; Verapamil	1987
Direct intrauterine fetal treatment of fetal tachyarrhythmia with severe hydrops fetalis by antiarrhythmic drugs. Fetal therapy, 1988, Volume: 3, Issue:4 Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Medigoxin; Pregnancy; Propafenone; Tachycardia; Verapamil	1988
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. Japanese journal of pharmacology, 1995, Volume: 68, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Chlorobenzenes; Digitalis Glycosides; Disease Models, Animal; Disopyramide; Dogs; Epinephrine; Female; Flecainide; Injections, Intra-Arterial; Lidocaine; Male; Ouabain; Verapamil	1995
Comparative haemodynamic effects of verapamil, flecainide, amiodarone and sotalol in the conscious rabbit. Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:3 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Autonomic Nerve Block; Autonomic Nervous System; Cardiac Output; Cardiac Pacing, Artificial; Consciousness; Flecainide; Heart; Heart Atria; Heart Rate; Hemodynamics; Male; Rabbits; Sotalol; Verapamil	1994
Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats. Anesthesiology, 1993, Volume: 79, Issue:3 Topics: Amiodarone; Anesthesia, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephrine; Flecainide; Halothane; Isoflurane; Lidocaine; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Verapamil	1993
Changes in canine ventricular fibrillation threshold induced by verapamil, flecainide and bretylium. European heart journal, 1993, Volume: 14, Issue:5 Topics: Animals; Bretylium Compounds; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Flecainide; Ventricular Fibrillation; Verapamil	1993
[Role of a "bystander" concealed accessory pathway in the response to verapamil and flecainide treatment in a patient with nodal reentry tachycardia]. Giornale italiano di cardiologia, 1996, Volume: 26, Issue:4 Topics: Anti-Arrhythmia Agents; Child; Echocardiography; Electrocardiography, Ambulatory; Flecainide; Heart Conduction System; Humans; Male; Tachycardia, Paroxysmal; Tachycardia, Sinoatrial Nodal Reentry; Tachycardia, Supraventricular; Verapamil	1996
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart. Heart (British Cardiac Society), 1996, Volume: 76, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil	1996
Effects of verapamil in ventricular tachycardias. An experimental and clinical study. Acta cardiologica, 1997, Volume: 52, Issue:1 Topics: Aconitine; Adult; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Flecainide; Humans; Lidocaine; Tachycardia, Ventricular; Verapamil	1997
Quantitative determination of disopyramide, verapamil and flecainide enantiomers in rat plasma and tissues by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1998, Jun-12, Volume: 710, Issue:1-2 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Male; Rats; Rats, Wistar; Stereoisomerism; Verapamil	1998
Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding. Pharmaceutical research, 1998, Volume: 15, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Blood Proteins; Disopyramide; Flecainide; Male; Phosphatidylserines; Protein Binding; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution; Verapamil	1998
Fetal tachycardias: management and outcome of 127 consecutive cases. Heart (British Cardiac Society), 1998, Volume: 79, Issue:6 Topics: Adenosine; Amiodarone; Anti-Arrhythmia Agents; Chi-Square Distribution; Digoxin; Female; Fetal Distress; Fetus; Flecainide; Humans; Hydrops Fetalis; Maternal-Fetal Exchange; Pregnancy; Retrospective Studies; Statistics, Nonparametric; Verapamil	1998
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current. Circulation, 1999, Mar-30, Volume: 99, Issue:12 Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil	1999
Opposite change with ischaemia in the antifibrillatory effects of class I and class IV antiarrhythmic drugs resulting from the alteration in ion transmembrane exchanges related to depolarization. Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Flecainide; Myocardial Ischemia; Sodium Channel Blockers; Swine; Ventricular Fibrillation; Verapamil	2000
Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes. Cardiovascular research, 2000, Volume: 46, Issue:1 Topics: Aminobenzoates; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels, L-Type; Dogs; Dose-Response Relationship, Drug; Flecainide; Heart Atria; Myocardium; Patch-Clamp Techniques; Potassium Channels; Quinidine; Time Factors; Verapamil	2000
Alteration of ventricular fibrillation by flecainide, verapamil, and sotalol: an experimental study. Circulation, 2000, Apr-04, Volume: 101, Issue:13 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiology; Flecainide; Heart Conduction System; Rabbits; Refractory Period, Electrophysiological; Sotalol; Ventricular Fibrillation; Verapamil	2000
Idiopathic sustained left ventricular tachycardia in pediatric patients. Pediatrics international : official journal of the Japan Pediatric Society, 2001, Volume: 43, Issue:1 Topics: Adolescent; Anti-Arrhythmia Agents; Child; Child, Preschool; Electrophysiology; Female; Flecainide; Follow-Up Studies; Humans; Male; Prognosis; Propranolol; Tachycardia, Ventricular; Treatment Outcome; Verapamil	2001
Symptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case report. The Journal of emergency medicine, 2002, Volume: 22, Issue:3 Topics: Administration, Topical; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Bradycardia; Drug Interactions; Female; Flecainide; Glaucoma; Humans; Middle Aged; Ophthalmic Solutions; Timolol; Verapamil	2002
Cardioversion threshold, IRAF and beyond. European heart journal, 2004, Volume: 25, Issue:11 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Flecainide; Humans; Verapamil	2004
Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart rhythm, 2004, Volume: 1, Issue:2 Topics: Ajmaline; Animals; Bundle-Branch Block; Calcium Channel Blockers; Dogs; Electrocardiography; Flecainide; Procainamide; Sodium Channel Blockers; Terfenadine; Verapamil	2004
Warming and response to contractile agents in calf cardiac vein: role of the Ca2+, KCa2+, and Na+ ion channel blockers. Methods and findings in experimental and clinical pharmacology, 2005, Volume: 27, Issue:9 Topics: Animals; Caffeine; Calcium Channel Blockers; Carbachol; Cattle; Coronary Vessels; Egtazic Acid; Flecainide; Hot Temperature; In Vitro Techniques; Potassium Channel Blockers; Quaternary Ammonium Compounds; Serotonin; Sodium Channel Blockers; Vasoconstriction; Verapamil	2005
Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers. Anesthesia and analgesia, 2006, Volume: 103, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Flecainide; Halothane; Ion Channels; Male; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Verapamil	2006
Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4ΔN channel currents in Xenopus oocytes. Acta pharmacologica Sinica, 2013, Volume: 34, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Female; Flecainide; Gene Expression; Kv1.4 Potassium Channel; Mutation; Oocytes; Verapamil; Xenopus	2013
A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosensors & bioelectronics, 2013, Nov-15, Volume: 49 Topics: Animals; Anti-Arrhythmia Agents; Biosensing Techniques; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Equipment Design; Flecainide; Humans; Myocytes, Cardiac; Rats; Verapamil	2013
Combined inhibition of Na⁺ and Ca²⁺ channels: a novel paradigm for the treatment of incessant ventricular arrhythmias in Andersen-Tawil syndrome. Heart rhythm, 2014, Volume: 11, Issue:2 Topics: Adolescent; Andersen Syndrome; Arrhythmias, Cardiac; Calcium Channel Blockers; Electrocardiography, Ambulatory; Flecainide; Humans; Male; Sodium Channel Blockers; Ventricular Premature Complexes; Verapamil	2014
Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors. The Journal of toxicological sciences, 2019, Volume: 44, Issue:7 Topics: Animals; Astemizole; Body Temperature; Calcium Channel Blockers; Callithrix; Electrocardiography; Flecainide; Male; Models, Animal; Quinidine; Risk Assessment; Sotalol; Telemetry; Terfenadine; Verapamil; Voltage-Gated Sodium Channel Blockers	2019
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Oct-15, Volume: 1129 Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil	2019
The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles. Scientific reports, 2020, 03-24, Volume: 10, Issue:1 Topics: Animals; Anthropometry; Atenolol; Cardiotonic Agents; Digoxin; Dobutamine; Electric Stimulation; Flecainide; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Verapamil	2020
The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia: a Retrospective Multi-Center Study. Pediatric cardiology, 2021, Volume: 42, Issue:4 Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Child; Child, Preschool; Female; Flecainide; Humans; Male; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Ventricular Premature Complexes; Verapamil	2021
Pharmacological characterisation of electrocardiogram J-T European journal of pharmacology, 2022, Jul-15, Volume: 927 Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil	2022
Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes. Stem cell research & therapy, 2023, 09-23, Volume: 14, Issue:1 Topics: Anti-Arrhythmia Agents; Calcium; Flecainide; Humans; Myocytes, Cardiac; Precision Medicine; Propranolol; Ryanodine Receptor Calcium Release Channel; Tachycardia, Ventricular; Verapamil	2023