verapamil and fexofenadine

verapamil has been researched along with fexofenadine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.86)	18.2507
2000's	16 (45.71)	29.6817
2010's	17 (48.57)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Cvetkovic, M; Fromm, MF; Kim, RB; Leake, B; Wilkinson, GR	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Chen, XL; Hendrix, J; Kang, J; Korolev, AM; Lysenkova, LN; Miroshnikova, OV; Pearlstein, RA; Preobrazhenskaya, M; Rampe, D; Shchekotikhin, AE; Vaz, RJ	1
Lennernäs, H; Petri, N; Rungstad, D; Tannergren, C	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Caron, G; Ermondi, G; Visentin, S	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Avdeef, A; Tam, KY	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Sen, S; Sinha, N	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dagenais, C; Ducharme, J; Pollack, GM	1
Greenblatt, DJ; Perloff, MD; von Moltke, LL	1
Bondesson, U; Hedeland, M; Knutson, L; Lennernäs, H; Petri, N; Tannergren, C	1
Sugawara, K; Tateishi, T; Uno, T; Yasui-Furukori, N	1
Fukuda, H; Kamikozawa, Y; Ohashi, R; Sugiura, M; Tamai, I; Yabuuchi, H	1
Gorski, JC; Hall, SD; Hamman, MA; Lemma, GL; Wang, Z; Zaheer, NA	1
Bergman, E; Bondesson, U; Forsell, P; Hedeland, M; Knutson, L; Lennernäs, H; Petri, N	1
Nemes, P; Vertes, A	1
Hokama, N; Miura, M; Sakugawa, T; Suzuki, T; Tateishi, T; Uno, T	1
Miura, M; Uno, T	1
Ai, H; Gu, Y; Hao, G; Li, Y; Peng, Y; Sun, J; Wang, G; Wu, X; Zhang, J; Zhang, X; Zheng, Y; Zhou, F	1
Hosoi, Y; Kanamaru, T; Konno, T; Nakagami, H; Tajiri, S; Yada, S; Yoshida, K	1
Ohkawa, T; Tanaka, Y; Yasui, H	1
Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T	1
Bondesson, U; Hedeland, M; Lennernäs, H; Sjögren, E	1
Bedada, SK; Neerati, P; Yellu, NR	1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N	1

Reviews

3 review(s) available for verapamil and fexofenadine

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical pharmacokinetics of fexofenadine enantiomers. Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:1 Topics: Antifungal Agents; Calcium Channel Blockers; Drug Interactions; Histamine H1 Antagonists; Humans; Itraconazole; Stereoisomerism; Terfenadine; Verapamil	2010

Trials

4 trial(s) available for verapamil and fexofenadine

Article	Year
Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:5 Topics: Adult; Algorithms; Anti-Allergic Agents; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Female; Humans; In Vitro Techniques; Intestinal Absorption; Intestines; Jejunum; Male; Membrane Transport Modulators; Membrane Transport Proteins; Regional Blood Flow; Spectrophotometry, Ultraviolet; Terfenadine; Verapamil	2003
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics. Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:1 Topics: Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cimetidine; Drug Interactions; Half-Life; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Probenecid; Terfenadine; Uricosuric Agents; Verapamil	2005
The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates. Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:3 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Female; Half-Life; Histamine H1 Antagonists; Humans; Male; Stereoisomerism; Terfenadine; Tissue Distribution; Verapamil	2006
Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil. British journal of clinical pharmacology, 2009, Volume: 67, Issue:5 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Terfenadine; Verapamil; Young Adult	2009

Other Studies

28 other study(ies) available for verapamil and fexofenadine

Article	Year
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:8 Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Genes, MDR; HeLa Cells; Histamine H1 Antagonists; Humans; LLC-PK1 Cells; Mice; Rats; Swine; Terfenadine; Tissue Distribution; Transfection; Vaccinia virus	1999
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 Topics: Amino Acids, Aromatic; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structural Homology, Protein; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG	2003
Transport characteristics of fexofenadine in the Caco-2 cell model. Pharmaceutical research, 2004, Volume: 21, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Diffusion; Humans; Inhibitory Concentration 50; Kinetics; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Permeability; Terfenadine	2004
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Uptake and efflux of the peptidic delta-opioid receptor agonist. Neuroscience letters, 2001, Apr-06, Volume: 301, Issue:3 Topics: Analgesics, Opioid; Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Calcium Channel Blockers; Carrier Proteins; Digoxin; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Estradiol; Histamine H1 Antagonists; Male; Mice; Mice, Knockout; Perfusion; Receptors, Opioid, delta; Terfenadine; Verapamil	2001
Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir. Journal of clinical pharmacology, 2002, Volume: 42, Issue:11 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Depression, Chemical; Drug Interactions; Drug Stability; Fluorometry; Histamine H1 Antagonists; Humans; In Vitro Techniques; Kinetics; Rhodamines; Ritonavir; Terfenadine; Time Factors; Verapamil	2002
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5 Topics: Adenosine Triphosphatases; Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Biological Transport, Active; Brain; Chromatography, Liquid; Intestinal Absorption; Kinetics; LLC-PK1 Cells; Male; Mass Spectrometry; Mice; Mice, Knockout; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Swine; Terfenadine; Verapamil	2006
First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Antipyrine; Bile; Calcium Channel Blockers; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Intestinal Absorption; Liver; Models, Animal; Perfusion; Swine; Terfenadine; Verapamil	2006
Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Analytical chemistry, 2007, Nov-01, Volume: 79, Issue:21 Topics: Atmospheric Pressure; Humans; Molecular Weight; Particle Size; Plant Leaves; Plant Roots; Plant Stems; Proteins; Reserpine; Seedlings; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tagetes; Terfenadine; Verapamil	2007
20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Digoxin; Etoposide; Ginsenosides; Herb-Drug Interactions; Humans; Ileum; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Terfenadine; Verapamil	2010
The relationship between the drug concentration profiles in plasma and the drug doses in the colon. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:10 Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil	2010
Development of a novel high-throughput analytical methodology, multiple injection method, for quantitative analysis in drug metabolism and pharmacokinetic studies using liquid chromatography with tandem mass spectrometry. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:8 Topics: Animals; Chromatography, High Pressure Liquid; Imipramine; Male; Ondansetron; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Risperidone; Tandem Mass Spectrometry; Terfenadine; Validation Studies as Topic; Verapamil	2011
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Nov-20, Volume: 44, Issue:4 Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine	2011
Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jun-16, Volume: 57 Topics: Animals; Bile; Biological Transport; Biotransformation; Chromatography, Liquid; Drug Interactions; Hepatobiliary Elimination; Infusions, Intravenous; Kidney; Liver; Male; Models, Biological; Swine; Tandem Mass Spectrometry; Terfenadine; Verapamil	2014
Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition. Pharmacological reports : PR, 2016, Volume: 68, Issue:2 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Drug Interactions; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Rats; Rats, Wistar; Resveratrol; Stilbenes; Terfenadine; Verapamil	2016
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4 Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil	2020