Compounds > verapamil

verapamil and elacridar

verapamil has been researched along with elacridar in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (18.60)18.2507
2000's17 (39.53)29.6817
2010's17 (39.53)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Daugan, A; Dodic, N; Dumaitre, B; Pianetti, P1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Besterman, JM; Chai, HB; Chávez, D; Cordell, GA; Cui, B; Farnsworth, NR; Kinghorn, AD; Lewis, JA; Lynn, SM; Monks, A; O'Neill, MJ; Pezzuto, JM; Rasoanaivo, P; Silva, GL; You, M1
Balsamo, A; Berardi, F; Colabufo, NA; Digiacomo, M; Perrone, R; Rapposelli, S1
Lemaire, S; Mingeot-Leclercq, MP; Tulkens, PM; Van Bambeke, F1
Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Porcelli, L; Simone, GM1
Balsamo, A; Berardi, F; Colabufo, NA; Digiacomo, M; Perrone, R; Rapposelli, S; Vanni, M1
Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Simone, GM1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Baubichon-Cortay, H; Falson, P; Ferreira, MU; Khonkarn, R; Madeira Girio, P; Moreno, A; Mulhovo, S; Paterna, A1
Chan, CF; Chan, KF; Chan, TH; Chong, TC; Chow, LMC; Chow, TS; Cui, J; Law, MC; Liu, Z; Wong, ILK; Zhu, X1
Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D1
Faussat, AM; Marie, JP; Simonin, G; Zhou, DC; Zittoun, R1
Baughman, TM; Bell, MG; Cao, J; Dantzig, AH; Ehlhardt, WJ; Elmquist, WF; Gruber, J; Kroin, JS; Law, KL; Norman, BH; Shepard, RL; Shih, C; Starling, JJ; Winter, MA1
Anderson, R; Jooné, G; Van Rensburg, CE1
Beck, JF; Boer, R; Buchholz, F; Gekeler, V; Niethammer, D; Sanders, KH; Ulrich, WR1
Covey, DF; Luker, GD; Nilsson, KR; Piwnica-Worms, D1
Chen, C; Pollack, GM1
Alvaro, D; Boyer, JL; Fraioli, F; Gigliozzi, A; Lee, J; Mennone, A; Sundaram, P1
Grand-Perret, T; Issandou, M1
Cisternino, S; Dagenais, C; Rousselle, C; Scherrmann, JM1
Fuchs, J; Geerlings, H; Göhring, G; Teichmann, B; Warmann, S1
Chanteux, H; Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F1
Honkakoski, P; Urtti, A; Vellonen, KS1
Chiou, WL; Yao, HM1
Choi, MK; Chung, SJ; Jin, QR; Kim, DD; Shim, CK; Shim, WS; Song, IS; Tian, GY; Yang, SG1
Amidon, GL; Dahan, A; Sabit, H1
Borchardt, RT; Jin, JY; Mudra, DR1
Bankstahl, JP; Bankstahl, M; Brauner, R; Ding, X; Karch, R; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Stundner, G; Wanek, T1
Wang, XD; Zeng, S1
Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T1
Bankstahl, JP; Bankstahl, M; Karch, R; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müllauer, J; Müller, M; Stanek, J; Wanek, T1
Aa, JY; Cao, B; Ge, C; Gu, RR; Li, MJ; Liu, CX; Liu, LS; Ma, T; Mao, Y; Shi, J; Sun, RB; Wang, GJ; Wang, XW; Wu, XL; Xia, WJ; Xiao, WJ; Yu, XY; Zha, WB; Zheng, T; Zhou, J1
Lamprecht, A; Singh, MS1
Hu, Y; Hu, Z; Huang, W; Li, Y; Wu, J; Zhou, Z1
Bauer, M; Hacker, M; Haslacher, H; Jäger, W; Jungbauer, C; Karch, R; Langer, O; Löscher, W; Maier-Salamon, A; Philippe, C; Römermann, K; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M1
Bray, SE; Chakravarty, P; Ferguson, MJ; Gannon, AL; Sawers, L; Scott, AL; Smith, G; Vaidyanathan, A1
Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S1
Carvalho, VFM; Costa, SKP; Giacone, DV; Lopes, LB1
Ambudkar, SV; Lusvarghi, S1

Other Studies

43 other study(ies) available for verapamil and elacridar

ArticleYear
Synthesis and activity against multidrug resistance in Chinese hamster ovary cells of new acridone-4-carboxamides.
    Journal of medicinal chemistry, 1995, Jun-23, Volume: 38, Issue:13

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; CHO Cells; Cricetinae; Cricetulus; Drug Resistance, Multiple; Mice; Structure-Activity Relationship

1995
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei.
    Journal of natural products, 2001, Volume: 64, Issue:12

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Crystallography, X-Ray; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Erythroxylaceae; Esters; Female; Humans; Madagascar; Medicine, Traditional; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Roots; Plants, Medicinal; Spectrophotometry, Infrared; Stereoisomerism; Tropanes; Tumor Cells, Cultured

2001
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.
    Journal of medicinal chemistry, 2006, Nov-02, Volume: 49, Issue:22

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Cell Line; Dose-Response Relationship, Drug; Doxorubicin; Flow Cytometry; Humans; Piperazines; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Vinblastine

2006
Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Daptomycin; Dogs; Humans; Kidney; Macrophages; Phagocytosis; Staphylococcus aureus

2007
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Female; Humans; Isoquinolines; Ligands; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines

2008
Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzene Derivatives; Biological Transport; Cell Line, Tumor; Cell Membrane Permeability; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Methylamines; Neoplasm Proteins; Pyridines; Structure-Activity Relationship

2008
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.
    Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line; Cell Proliferation; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Lipids; Molecular Structure; Naphthols; Structure-Activity Relationship; Tetrahydroisoquinolines

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Monoterpene indole alkaloid azine derivatives as MDR reversal agents.
    Bioorganic & medicinal chemistry, 2018, 01-15, Volume: 26, Issue:2

    Topics: Alkaloids; Animals; Cell Line; Cell Proliferation; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Hydrazines; Indoles; Mice; Molecular Structure; NIH 3T3 Cells; Structure-Activity Relationship

2018
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).
    Journal of medicinal chemistry, 2021, 10-14, Volume: 64, Issue:19

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; HEK293 Cells; Humans; Mitoxantrone; Neoplasm Proteins; Structure-Activity Relationship; Substrate Specificity

2021
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
    Anti-cancer drugs, 1997, Volume: 8, Issue:2

    Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine

1997
Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells.
    Leukemia, 1997, Volume: 11, Issue:9

    Topics: Acridines; Acute Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Drug Resistance, Multiple; Gene Expression; Humans; Idarubicin; Isoquinolines; Leukemia; Mitoxantrone; RNA, Messenger; RNA, Neoplasm; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

1997
Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.
    Advances in enzyme regulation, 1997, Volume: 37

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dibenzocycloheptenes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Isoquinolines; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Quinidine; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

1997
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.
    Cancer letters, 1998, May-15, Volume: 127, Issue:1-2

    Topics: Acridines; Cell Death; Clofazimine; Cyclosporine; Drug Resistance, Multiple; Humans; Isoquinolines; Lung Neoplasms; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil; Vinblastine; Vitamin E

1998
Rhodamine 123 efflux modulation in the presence of low or high serum from CD56+ hematopoietic cells or CD34+ leukemic blasts by B9309-068, a newly designed pyridine derivative.
    Cancer letters, 1998, Jul-17, Volume: 129, Issue:2

    Topics: Acridines; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood Proteins; Calcium Channel Blockers; CD56 Antigen; Cyclosporins; Dihydropyridines; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Morpholines; Multidrug Resistance-Associated Proteins; Pyrimidines; Rhodamine 123; Rhodamines; Tetrahydroisoquinolines; Verapamil

1998
Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol.
    The Journal of biological chemistry, 1999, Mar-12, Volume: 274, Issue:11

    Topics: 3T3 Cells; Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Cholesterol; Cyclosporins; Dehydroepiandrosterone; Dibenzocycloheptenes; Drug Resistance, Multiple; Esterification; Humans; Isoquinolines; Mice; Progesterone; Quinolines; Stereoisomerism; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

1999
Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation.
    Pharmaceutical research, 1999, Volume: 16, Issue:2

    Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Drug Administration Routes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Mice; Opioid Peptides; Pain Measurement; Tetrahydroisoquinolines; Tissue Distribution; Verapamil

1999
Molecular identification and functional characterization of Mdr1a in rat cholangiocytes.
    Gastroenterology, 2000, Volume: 119, Issue:4

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bile Ducts; Cell Division; Cell Membrane; Cytosol; Drug Resistance, Multiple; In Vitro Techniques; Isoquinolines; Kinetics; Male; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tetrahydroisoquinolines; Transcription, Genetic; Vanadates; Verapamil

2000
Multidrug resistance P-glycoprotein is not involved in cholesterol esterification.
    Biochemical and biophysical research communications, 2000, Dec-20, Volume: 279, Issue:2

    Topics: Acridines; Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholesterol; Cholesterol Esters; DNA-Binding Proteins; Fluoresceins; Fluorescent Dyes; Heptanoic Acids; Humans; Isoquinolines; Kinetics; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Probenecid; Progesterone; Pyrroles; Sterol O-Acyltransferase; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

2000
Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice.
    Pharmaceutical research, 2001, Volume: 18, Issue:2

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Colchicine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Isoquinolines; Male; Mice; Perfusion; Tetrahydroisoquinolines; Time Factors; Verapamil; Vinblastine

2001
MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro.
    Journal of pediatric surgery, 2002, Volume: 37, Issue:11

    Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression; Genes, MDR; Hepatoblastoma; Humans; Inhibitory Concentration 50; Isoquinolines; Liver Neoplasms; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

2002
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:3

    Topics: Acridines; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cell Line; Cyclosporine; Cytosol; Gemfibrozil; Isoquinolines; Lysosomes; Macrophages; Mice; Microscopy, Confocal; Monensin; Probenecid; Tetrahydroisoquinolines; Verapamil

2003
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 23, Issue:2

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cattle; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Humans; L-Lactate Dehydrogenase; Multidrug Resistance-Associated Proteins; Oxidation-Reduction; Propionates; Quinolines; Tetrahydroisoquinolines; Tetrazolium Salts; Thiazoles; Verapamil

2004
The complexity of intestinal absorption and exsorption of digoxin in rats.
    International journal of pharmaceutics, 2006, Sep-28, Volume: 322, Issue:1-2

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Microvilli; Organic Anion Transporters; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Tetrahydroisoquinolines; Verapamil

2006
Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:10

    Topics: Acridines; Acute Kidney Injury; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Camptothecin; Down-Regulation; Folic Acid; Glomerular Filtration Rate; Indicators and Reagents; Kidney; Male; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil; Vitamin B Complex

2009
Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:10

    Topics: Acridines; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Colchicine; Drug Interactions; Epithelium; Food-Drug Interactions; Humans; Ileum; Indoles; Intestinal Absorption; Intestine, Small; Jejunum; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxotremorine; p-Aminohippuric Acid; Permeability; Rats; Rats, Wistar; Tetrahydroisoquinolines; Verapamil

2009
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:2

    Topics: Acridines; Adrenergic beta-Antagonists; Algorithms; Animals; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Computer Simulation; Cyclosporins; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Models, Statistical; Pharmaceutical Preparations; Rats; Tetrahydroisoquinolines; Verapamil

2010
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:5

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Blood-Brain Barrier; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrahydroisoquinolines; Verapamil

2010
The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:12

    Topics: Acridines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzyl Alcohols; Biological Transport; Blood-Brain Barrier; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Drug Resistance, Multiple; Gastrodia; Glucosides; Humans; Plants, Medicinal; Prohibitins; Rhodamine 123; Tetrahydroisoquinolines; Verapamil

2010
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
    European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:1

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Mice; Phenotype; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Verapamil

2012
Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
    Nuclear medicine and biology, 2013, Volume: 40, Issue:6

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Carbon Radioisotopes; Female; Gene Expression Regulation; Kinetics; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil

2013
Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:10

    Topics: Acridines; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chromatography, Liquid; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Ginsenosides; HIV Protease Inhibitors; Humans; Injections, Intravenous; Madin Darby Canine Kidney Cells; Male; Mass Spectrometry; Rats; Rats, Wistar; Ritonavir; Tetrahydroisoquinolines; Tissue Distribution; Verapamil

2013
Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin.
    International journal of pharmaceutics, 2015, Jan-30, Volume: 478, Issue:2

    Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm; Humans; Nanoparticles; Neoplasms; Polyvinyl Alcohol; Sodium Dodecyl Sulfate; Surface-Active Agents; Tetrahydroisoquinolines; Verapamil

2015
HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Dogs; Drug Resistance, Multiple; Humans; Isoquinolines; KB Cells; Madin Darby Canine Kidney Cells; Mice; Neoplasms; Tetrahydroisoquinolines; Transplantation, Heterologous; Verapamil

2015
Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier.
    Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:2

    Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Female; Humans; Male; Neoplasm Proteins; Pilot Projects; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Tissue Distribution; Verapamil; Young Adult

2016
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells.
    British journal of cancer, 2016, 08-09, Volume: 115, Issue:4

    Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Humans; Immunohistochemistry; Ovarian Neoplasms; Paclitaxel; Phthalazines; Piperazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydroisoquinolines; Verapamil

2016
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
    The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil

2017
Evidence That P-glycoprotein Inhibitor (Elacridar)-Loaded Nanocarriers Improve Epidermal Targeting of an Anticancer Drug via Absorptive Cutaneous Transporters Inhibition.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2

    Topics: Acridines; Administration, Cutaneous; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Carriers; Emulsions; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Particle Size; Skin; Tetrahydroisoquinolines; Verapamil

2018
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
    The Biochemical journal, 2019, 12-19, Volume: 476, Issue:24

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil

2019