verapamil and disopyramide

verapamil has been researched along with disopyramide in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (49.55)	18.7374
1990's	24 (21.62)	18.2507
2000's	18 (16.22)	29.6817
2010's	13 (11.71)	24.3611
2020's	1 (0.90)	2.80

Authors

Authors	Studies
Giacomini, KM; Schaner, ME; Zhang, L	1
Topliss, JG; Yoshida, F	1
Keserü, GM	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Sen, S; Sinha, N	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Esaki, T; Kawashima, H; Komura, H; Kuroda, M; Mizuguchi, K; Natsume-Kitatani, Y; Ohashi, R; Watanabe, R	1
Theisen, K	2
Donaldson, RM	1
Landmark, K; Storstein, O	1
Troup, PJ; Zipes, DP	1
Federman, J; Vlietstra, RE	1
Chiba, S; Furukawa, Y; Kobayashi, M	1
Anderson, JL; Harrison, DC; Meffin, PJ; Winkle, RA	1
Loogen, F	1
Araú, A; Bonhorst, D; Bordalo, A; De Azevedo, JG; Ferreira, M; Ferreira, R; Inês, L; Lacximy, I; Longo, A; Luis Martins, J; Melo, M; Nunes Diogo, A; Ribeiro, C; Sanches, C; Teixeira, J	1
Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M	1
Boachie-Ansah, G; Kane, KA; Pacini, DJ	1
Fomina, IG; Iankin, VV	1
Garthwaite, SM; Hackett, AM; McDonald, SJ; Schneider, P; Schweingruber, F	1
Ohe, T; Shimomura, K; Takagaki, K	1
Antonchenko, IV; Borisova, EV; Chekhov, AM; Gimrikh, EO; Plekhanov, IG; Popov, SV; Savenkova, GM	1
Hashimoto, M; Kajiyama, G; Matsuura, H; Nakagawa, H; Okamoto, M; Sakura, E; Tsuchioka, Y; Yamagata, T	1
Akiyama, K; Hashimoto, K	1
Keefe, DL; Miura, D; Somberg, JC	1
Kidwell, GA; Muir, WW; Schaal, SF	1
Deguchi, N; Naitoh, M; Saruta, T; Suzuki, H; Tominaga, T	1
Hoffmeister, HM; Krämer, B; Pflug, A; Seipel, L	1
Inoue, T; Ito, S; Koumatsu, A; Maeda, T; Nanimatsu, H; Saikawa, T; Shibayama, H; Takaki, R; Tsunematsu, Y	1
Allessie, MA; Bonke, FI; Kirchhof, CJ	1
Somberg, J	1
Andersson, KE; Wettrell, G	1
Morganroth, J; Nestico, PF	1
Huang, SK; Marcus, FI	1
Augsten, G; Pfeiffer, D; Rathgen, K; Rostock, KJ	1
Ishinaga, T; Komatsu, C; Tateishi, O; Tokuhisa, Y; Yoshimura, S	1
Hirosawa, K; Kasanuki, H; Onishi, S	1
Hiejima, K; Hirao, K; Kubo, I; Moroi, Y; Satake, S; Suzuki, F	1
Bertrix, L; Bouzouita, K; Faucon, G; Lakhal, M; Lang, J; Timour Chah, Q	1
Hashimoto, K; Imai, S; Shibuya, T	1
Hauswirth, O; Singh, BN	1
Opie, LH	1
Lawrie, TD	1
DiBianco, R; Fletcher, RD; Gottdiener, JS	1
Attuel, P; Coumel, P; Georgiopoulos, G; Halkidis, H; Leclercq, JF; Maisonblanche, P	1
Lüderitz, B	1
Elkayam, U; Frishman, W; Rotmensch, HH	1
de Moura, RS; Lima, JS	1
Hillis, WS; Whiting, B	1
Prystowsky, EN	1
Ali, C; Holt, DW; Volans, GN	1
Somberg, JC	1
Jahrmärker, H; Theisen, K	1
Mohiuddin, SM; Ross, WB	1
Rosen, MR; Wit, AL	1
Ronfeld, RA	1
Jewitt, DE	1
Harrison, DC; Kates, RE; Keefe, DL	1
Hirosawa, K; Kasanuki, H; Ohnishi, S	1
Hashimoto, K; Imai, S; Satoh, H; Shibuya, T	2
Hiejima, K; Satake, S; Suzuki, F; Takahashi, M	1
Funke, H; Grube, E; Neumann, G	1
Dreifus, LS; Morganroth, J	1
Abbott, JA	1
Ardlie, NG; Boatwright, C; Han, P	1
Beck, OA; Günther, R; Hochrein, H	1
Hasin, Y; Rogel, S; Sarel, O	1
Kawai, C; Konishi, T; Matsuda, H; Matsuyama, E; Tamamura, T	1
Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C	1
Haruno, A; Hashimoto, K	1
Ishii, K; Taira, N; Yamagishi, T	1
Lüderitz, B; Manz, M	1
Giacomini, KM; Ott, RJ	1
Eichler, HG; Gouya, G; Schmetterer, L; Wolzt, M; Zanaschka, G	1
Aizawa, Y; Mitamura, H; Miyazaki, T; Miyoshi, S; Ogawa, S; Soejima, K	1
Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ	1
Jamali, F; Mehvar, R	1
Gunsburg, DZ; Pearle, G; Sherrid, MV	1
Akimoto, S; Hanada, K; Hashiguchi, M; Mitsui, K; Ogata, H	1
Akimoto, S; Hanada, K; Mihara, K; Mitsui, K; Ogata, H	1
Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S	1
Hagihara, A; Hashimoto, K; Sugiyama, A	1
Hanada, K; Kudo, A; Odaka, K; Ogata, H	1
Arai, M; Hanada, K; Hirai, M; Ogata, H; Ohta, T	1
Dohmoto, H; Hashimoto, K; Sugiyama, A; Takahara, A; Yoshimoto, R	1
Kita, Y; Kuroda, Y; Nakagawa, T; Shibukawa, A	1
Hashimoto, K; Kase, J; Masumiya, H; Nakazawa, T; Noguchi, K; Saitoh, M; Shigenobu, K; Tanaka, H; Tanaka, Y	1
Kuroda, Y; Nakagawa, T; Shibukawa, A	1
Ali, SS; Malik, A; Rahmatullah, A	1
Musat, D; Sherrid, MV	1
Gibelin, P	1
Imai, T; Kajimoto, K; Kasanuki, H; Minami, Y	1
Alviar, CL; Balaram, SK; Homel, P; Kim, B; Musat, D; Sherrid, MV; Shetty, A; Swistel, DG; Winson, G	1
Nishimura, RA; Ommen, SR; Sorajja, P	1

Reviews

25 review(s) available for verapamil and disopyramide

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
New antiarrhythmic agents: amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil. The American journal of cardiology, 1978, May-22, Volume: 41, Issue:6 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Electrophysiology; Humans; Mexiletine; Morpholines; Phenothiazines; Verapamil	1978
The treatment of ventricular rhythm disturbances. American heart journal, 1986, Volume: 111, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil	1986
[Antiarrhythmic agent caused marked hypoglycemia in a patient receiving hemodialysis: relation with disopyramide and verapamil]. Nihon Naibunpi Gakkai zasshi, 1988, Nov-20, Volume: 64, Issue:11 Topics: Aged; Blood Glucose; Cardiac Complexes, Premature; Disopyramide; Drug Therapy, Combination; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Insulin Secretion; Male; Renal Dialysis; Verapamil	1988
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Cardiovascular drugs. I: Antidysrhythmic drugs. Therapeutic drug monitoring, 1986, Volume: 8, Issue:1 Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Disopyramide; Drug Interactions; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Tocainide; Verapamil	1986
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
Comparative mechanisms of action of antiarrhythmic drugs. American heart journal, 1974, Volume: 87, Issue:3 Topics: Action Potentials; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans; Benzyl Compounds; Bretylium Compounds; Calcium; Carbamazepine; Chemical Phenomena; Chemistry; Diethylamines; Disopyramide; Heart; Humans; Imidazoles; Iodobenzoates; Lidocaine; Membrane Potentials; Phenyl Ethers; Phenytoin; Procainamide; Propylamines; Quinidine; Verapamil	1974
Comparison of newer antiarrhythmic agents. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Disopyramide; Humans; Mexiletine; Tocainide; Verapamil	1980
Effects of antiarrhythmic agents on cardiac function. Angiology, 1982, Volume: 33, Issue:4 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Dogs; Encainide; Hemodynamics; Humans; Myocardial Contraction; Quinidine; Verapamil	1982
Antiarrhythmic drug therapy during pregnancy. Annals of internal medicine, 1983, Volume: 98, Issue:4 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Digitalis Glycosides; Disopyramide; Female; Fetus; Humans; Infant, Newborn; Lidocaine; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Pregnancy Complications, Cardiovascular; Procainamide; Quinidine; Tachycardia; Verapamil	1983
Pharmacologic therapy of tachyarrhythmias in patients with Wolff-Parkinson-White syndrome. Herz, 1983, Volume: 8, Issue:3 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Ajmaline; Amiodarone; Anilides; Aprindine; Atrial Fibrillation; Benzofurans; Digitalis Glycosides; Disopyramide; Encainide; Female; Humans; Lidocaine; Male; Middle Aged; Procainamide; Quinidine; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome	1983
[Medical treatment of extrasystole and tachycardia (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1980, Jan-18, Volume: 122, Issue:3 Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Digoxin; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil	1980
Electropharmacology of antiarrhythmic drugs. American heart journal, 1983, Volume: 106, Issue:4 Pt 2 Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil	1983
Comparative pharmacokinetics of new antiarrhythmic drugs. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Humans; Kinetics; Mexiletine; Piperidines; Tocainide; Verapamil	1980
Hemodynamic effects of newer antiarrhythmic drugs. American heart journal, 1980, Volume: 100, Issue:6 Pt 2 Topics: Acebutolol; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Atenolol; Benzeneacetamides; Disopyramide; Dogs; Hemodynamics; Humans; Mexiletine; Piperidines; Tocainide; Verapamil	1980
New antiarrhythmic drugs: their place in therapy. Drugs, 1981, Volume: 22, Issue:5 Topics: Action Potentials; Ajmaline; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Tosylate; Disopyramide; Encainide; Hemodynamics; Humans; Kinetics; Moricizine; Morpholines; Phenothiazines; Piperidines; Verapamil	1981
Antiarrhythmic agents and their use in therapy. Pharmacology & therapeutics, 1980, Volume: 9, Issue:1 Topics: Acebutolol; Animals; Anti-Arrhythmia Agents; Digitalis Glycosides; Disopyramide; Humans; Lidocaine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil	1980
Intravenous antiarrhythmic drugs: newer aspects of therapy. Angiology, 1982, Volume: 33, Issue:4 Topics: Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Lidocaine; Tachycardia; Verapamil	1982
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy. European heart journal, 1993, Volume: 14 Suppl E Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil	1993
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods. Clinical pharmacokinetics, 1997, Volume: 33, Issue:2 Topics: Adrenergic Uptake Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Computer Simulation; Disopyramide; Doxepin; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Guidelines as Topic; Hydroxychloroquine; Ibuprofen; Nadolol; Nortriptyline; Propafenone; Stereoisomerism; Therapeutic Equivalency; Verapamil	1997
[Drug binding analysis of human alpha 1-acid glycoprotein using capillary electrophoresis]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2003, Volume: 123, Issue:9 Topics: Binding Sites; Disopyramide; Electrophoresis, Capillary; Genetic Variation; Humans; Orosomucoid; Polysaccharides; Protein Binding; Stereoisomerism; Verapamil	2003
Pathophysiology of hypertrophic cardiomyopathy determines its medical treatment. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2006, Volume: 6 Suppl 2 Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Decision Trees; Defibrillators, Implantable; Disopyramide; Humans; Verapamil	2006

Trials

4 trial(s) available for verapamil and disopyramide

Article	Year
[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes]. Klinicheskaia meditsina, 1992, Volume: 70, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Pre-Excitation Syndromes; Procainamide; Propranolol; Quinidine; Time Factors; Verapamil	1992
[Evaluation of the possibility of selection of individual anti-arrhythmia therapy]. Kardiologiia, 1991, Volume: 31, Issue:3 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Humans; Middle Aged; Phenothiazines; Propranolol; Tachycardia, Atrioventricular Nodal Reentry; Verapamil	1991
[Conversion of chronic atrial fibrillation or flutter with disopyramide and a verapamil-quinidine combination: a comparative study ]. Deutsche medizinische Wochenschrift (1946), 1982, Sep-24, Volume: 107, Issue:38 Topics: Aged; Atrial Flutter; Disopyramide; Drug Combinations; Female; Humans; Male; Middle Aged; Pyridines; Quinidine; Verapamil	1982
Is the ECG measure RSh a promising technique for detecting class I antiarrhythmic drug action in men? Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4 Topics: Adenosine; Adult; Ajmaline; Anti-Arrhythmia Agents; Atropine; Disopyramide; Electrocardiography; Humans; Injections, Intravenous; Isoproterenol; Male; Norepinephrine; Propranolol; Reproducibility of Results; Sodium Channel Blockers; Verapamil	1995

Other Studies

82 other study(ies) available for verapamil and disopyramide

Article	Year
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of an Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cell Line; Computer Simulation; Endothelial Cells; Gene Knockout Techniques; Humans; Organic Chemicals; Rats, Transgenic	2021
[Drug therapy of tachyarrhythmias (author's transl)]. Klinische Wochenschrift, 1978, Feb-15, Volume: 56, Issue:4 Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil	1978
The treatment of supraventricular arrhythmias. British journal of hospital medicine, 1979, Volume: 21, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Digoxin; Disopyramide; Electric Countershock; Humans; Phenytoin; Procainamide; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil	1979
Ectopic atrial tachycardia on swallowing. Report on favourable effect of verapamil. Acta medica Scandinavica, 1979, Volume: 205, Issue:3 Topics: Atrioventricular Node; Atropine; Cardiac Complexes, Premature; Deglutition; Disopyramide; Edrophonium; Electrocardiography; Female; Heart Atria; Heart Block; Hernia, Diaphragmatic; Hernia, Hiatal; Humans; Middle Aged; Practolol; Tachycardia; Verapamil	1979
Series on pharmacology in practice. 2. Antiarrhythmic drug therapy. Mayo Clinic proceedings, 1979, Volume: 54, Issue:8 Topics: Anti-Arrhythmia Agents; Bretylium Compounds; Disopyramide; Humans; Lidocaine; Metoprolol; Procainamide; Propranolol; Quinidine; Verapamil	1979
Effects of disopyramide on SA nodal pacemaker activity and contractility in the isolated blood-perfused atrium of the dog. European journal of pharmacology, 1979, Jul-15, Volume: 57, Issue:1 Topics: Animals; Blood Pressure; Calcium; Disopyramide; Dogs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Procainamide; Pyridines; Sinoatrial Node; Verapamil	1979
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses. Drugs, 1978, Volume: 15, Issue:4 Topics: Acebutolol; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digitalis Glycosides; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil	1978
[Sino-atrial conduction time]. Deutsche medizinische Wochenschrift (1946), 1977, Mar-18, Volume: 102, Issue:11 Topics: Ajmaline; Disopyramide; Heart Conduction System; Humans; Phenytoin; Quinidine; Time Factors; Verapamil	1977
Mechanism of action of antidysrhythmic drugs on ventricular conduction as studied with intramural electrodes. Advances in cardiology, 1975, Volume: 14 Topics: Ajmaline; Animals; Disopyramide; Dogs; Electrocardiography; Heart Conduction System; Hydroxyzine; Lidocaine; Oxprenolol; Phenytoin; Propranolol; Purkinje Fibers; Quinidine; Verapamil	1975
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes. Pharmaceutical research, 1992, Volume: 9, Issue:9 Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil	1992
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs. British journal of pharmacology, 1992, Volume: 107, Issue:3 Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Electrophysiology; Heart; Hyperkalemia; Hypoxia; In Vitro Techniques; Lidocaine; Propanolamines; Propranolol; Purkinje Fibers; Sheep; Verapamil	1992
Simple in vitro method to characterize antiarrhythmic agents. Journal of pharmacological methods, 1990, Volume: 23, Issue:2 Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Quaternary Ammonium Compounds; Refractory Period, Electrophysiological; Sotalol; Verapamil	1990
Repetitive nonsustained monomorphic ventricular tachycardia aborted by methoxamine and sleep "heart rate dependent ventricular tachycardia". Pacing and clinical electrophysiology : PACE, 1991, Volume: 14, Issue:10 Topics: Adult; Cardiac Pacing, Artificial; Disopyramide; Electrocardiography; Electrocoagulation; Heart Rate; Humans; Male; Methoxamine; Propranolol; Sleep; Tachycardia; Verapamil	1991
[Effects of verapamil and disopyramide phosphate on the termination, reinduction and long-term prevention of paroxysmal supraventricular tachycardia]. Kokyu to junkan. Respiration & circulation, 1990, Volume: 38, Issue:3 Topics: Administration, Oral; Adult; Disopyramide; Drug Evaluation; Electrophysiology; Female; Humans; Injections, Intravenous; Male; Tachycardia, Supraventricular; Verapamil	1990
Effects of lidocaine, disopyramide and verapamil on the in vivo triggered ventricular arrhythmia in digitalized canine heart. Japanese journal of pharmacology, 1990, Volume: 53, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Verapamil	1990
Stereospecific effects of disopyramide enantiomers following pretreatment of canine cardiac Purkinje fibers with verapamil and nisoldipine. Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:3 Topics: Action Potentials; Animals; Disopyramide; Dogs; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Stereoisomerism; Verapamil	1987
Circulatory and myocardial effects of different sodium antagonistic drugs in comparison to the calcium antagonist verapamil. Arzneimittel-Forschung, 1989, Volume: 39, Issue:11 Topics: Animals; Cardiac Output; Disopyramide; Flecainide; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Quinidine; Rats; Rats, Inbred Strains; Sodium; Verapamil	1989
[Three cases of Torsades de pointes]. Kokyu to junkan. Respiration & circulation, 1989, Volume: 37, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Disopyramide; Electrocardiography; Female; Humans; Hypokalemia; Male; Tachycardia; Verapamil	1989
Effects of verapamil, diltiazem and disopyramide on sinus function: a comparison with bepridil. European journal of pharmacology, 1989, Feb-07, Volume: 160, Issue:3 Topics: Animals; Bepridil; Diltiazem; Disopyramide; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Pyrrolidines; Rabbits; Sinoatrial Node; Verapamil	1989
[Differential therapeutic problems in sinus node syndrome--drug or electrical therapy?]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Apr-01, Volume: 41, Issue:7 Topics: Anti-Arrhythmia Agents; Atropine; Bundle of His; Cardiac Glycosides; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Metaproterenol; Middle Aged; Pacemaker, Artificial; Prognosis; Sick Sinus Syndrome; Sinoatrial Node; Verapamil	1986
Effects of four antiarrhythmic drugs on the induction and termination of paroxysmal supraventricular tachycardia. Japanese circulation journal, 1986, Volume: 50, Issue:10 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Female; Humans; Male; Middle Aged; Procainamide; Propranolol; Tachycardia, Supraventricular; Verapamil	1986
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil	1985
Usefulness of invasive and non-invasive electrophysiologic studies in the selection of antiarrhythmic drugs for the patients with paroxysmal supraventricular tachyarrhythmia. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Bundle of His; Disopyramide; Electrocardiography; Electrodes; Female; Humans; Male; Middle Aged; Procainamide; Tachycardia, Paroxysmal; Verapamil; Wolff-Parkinson-White Syndrome	1985
Efficacy of disopyramide in comparison with verapamil and propranolol in the prevention of acetylcholine-induced atrial fibrillation in the dog. Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 274, Issue:1 Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; Disopyramide; Dogs; Electrocardiography; Female; In Vitro Techniques; Male; Propranolol; Verapamil	1985
Cardiovascular and respiratory effects of antiarrhythmic drugs on conscious beagles. The Tohoku journal of experimental medicine, 1985, Volume: 145, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Disopyramide; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Lidocaine; Male; Phenytoin; Procainamide; Respiration; Verapamil	1985
Drugs and the heart. IV. Antiarrhythmic agents. Lancet (London, England), 1980, Apr-19, Volume: 1, Issue:8173 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Heart Conduction System; Hemodynamics; Humans; Lidocaine; Mexiletine; Procainamide; Quinidine; Verapamil	1980
[Effects of anti-arrhythmia agents on heart rate. Significance and importance]. Archives des maladies du coeur et des vaisseaux, 1981, Volume: 74 Spec No Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Lidocaine; Propafenone; Propiophenones; Quinidine; Verapamil	1981
[Typical risks in the treatment of arrhythmias]. Der Internist, 1982, Volume: 23, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diagnostic Errors; Disopyramide; Drug Interactions; Humans; Risk; Verapamil	1982
Effect of disopyramide on isolated aortic ring of the rat. British journal of pharmacology, 1983, Volume: 78, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Calcium; Disopyramide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Pyridines; Rats; Rats, Inbred Strains; Verapamil	1983
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
[Pharmacotherapy of paroxysmal tachycardia]. Deutsche medizinische Wochenschrift (1946), 1983, Jul-01, Volume: 108, Issue:26 Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Atrial Flutter; Digitalis Glycosides; Disopyramide; Heart Failure; Humans; Quinidine; Tachycardia, Paroxysmal; Verapamil	1983
Management of cardiac drug overdose. Resuscitation, 1984, Volume: 11, Issue:3-4 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Digoxin; Disopyramide; Humans; Phenytoin; Poison Control Centers; Verapamil	1984
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
Antiarrhythmic therapy: new additions and future expectations. Geriatrics, 1983, Volume: 38, Issue:1 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Bretylium Tosylate; Disopyramide; Encainide; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil	1983
Availability of electrophysiological approach to the selection and assessment of antiarrhythmic drugs for recurrent ventricular tachycardia. Japanese circulation journal, 1983, Volume: 47, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Recurrence; Tachycardia; Verapamil	1983
Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations. Japanese circulation journal, 1983, Volume: 47, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Dogs; Female; Lidocaine; Male; Mexiletine; Phenytoin; Verapamil	1983
Electrophysiologic evaluation of antiarrhythmic drugs on supraventricular tachyarrhythmias. Japanese circulation journal, 1983, Volume: 47, Issue:1 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrioventricular Node; Disopyramide; Electric Stimulation; Humans; Procainamide; Tachycardia; Tachycardia, Paroxysmal; Verapamil	1983
[The value of antitachycardia pacemaker therapy in patients with Wolff-Parkinson-White syndrome]. Herz, 1983, Volume: 8, Issue:3 Topics: Anti-Arrhythmia Agents; Bundle of His; Digitalis Glycosides; Disopyramide; Electrocardiography; Humans; Mexiletine; Pacemaker, Artificial; Propafenone; Propiophenones; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome	1983
Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. Thrombosis and haemostasis, 1982, Apr-30, Volume: 47, Issue:2 Topics: Adenosine Triphosphate; Arachidonic Acids; Blood Platelets; Coronary Disease; Disopyramide; Humans; Platelet Aggregation; Propranolol; Pyridines; Thromboxane B2; Verapamil	1982
Canine-effective plasma concentrations of antiarrhythmic drugs on the two-stage coronary ligation arrhythmia. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Dose-Response Relationship, Drug; Isoquinolines; Lidocaine; Ligation; Phenytoin; Propanolamines; Verapamil	1982
Myocardial conduction time and antiarrhythmic drugs. Journal of electrocardiology, 1981, Volume: 14, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Quinidine; Ventricular Function; Verapamil	1981
Combined effect of verapamil and disopyramide on induction of circus movement tachycardia in patients with pre-excitation. Japanese circulation journal, 1981, Volume: 45, Issue:10 Topics: Adolescent; Adult; Atrioventricular Node; Disopyramide; Drug Synergism; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Pyridines; Refractory Period, Electrophysiological; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome	1981
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil	1995
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. Japanese journal of pharmacology, 1995, Volume: 68, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Chlorobenzenes; Digitalis Glycosides; Disease Models, Animal; Disopyramide; Dogs; Epinephrine; Female; Flecainide; Injections, Intra-Arterial; Lidocaine; Male; Ouabain; Verapamil	1995
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4. European journal of pharmacology, 1995, Aug-04, Volume: 281, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Cloning, Molecular; Disopyramide; Dose-Response Relationship, Drug; Mathematics; Oocytes; Potassium Channels; Quaternary Ammonium Compounds; Quinidine; Verapamil; Xenopus laevis	1995
Stereoselective interactions of organic cations with the organic cation transporter in OK cells. Pharmaceutical research, 1993, Volume: 10, Issue:8 Topics: Animals; Biological Transport, Active; Carrier Proteins; Cations; Cell Line; Disopyramide; Kidney; Microvilli; Opossums; Pindolol; Quinine; Stereoisomerism; Tetraethylammonium Compounds; Verapamil	1993
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. Journal of the American College of Cardiology, 1996, Volume: 27, Issue:5 Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Syndrome; Tachycardia, Ventricular; Verapamil	1996
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart. Heart (British Cardiac Society), 1996, Volume: 76, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil	1996
Mid-systolic drop in left ventricular ejection velocity in obstructive hypertrophic cardiomyopathy--the lobster claw abnormality. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 1997, Volume: 10, Issue:7 Topics: Acceleration; Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Blood Flow Velocity; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Deceleration; Disopyramide; Echocardiography; Echocardiography, Doppler; Echocardiography, Doppler, Pulsed; Feedback; Follow-Up Studies; Heart Septum; Heart Ventricles; Humans; Mitral Valve; Prospective Studies; Stroke Volume; Systole; Time Factors; Ventricular Function, Left; Ventricular Outflow Obstruction; Ventricular Pressure; Verapamil	1997
Quantitative determination of disopyramide, verapamil and flecainide enantiomers in rat plasma and tissues by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1998, Jun-12, Volume: 710, Issue:1-2 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Male; Rats; Rats, Wistar; Stereoisomerism; Verapamil	1998
Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding. Pharmaceutical research, 1998, Volume: 15, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Blood Proteins; Disopyramide; Flecainide; Male; Phosphatidylserines; Protein Binding; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution; Verapamil	1998
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current. Circulation, 1999, Mar-30, Volume: 99, Issue:12 Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil	1999
Effects of antiarrhythmic drugs on the monophasic action potential of the canine isolated, blood-perfused ventricular septum preparation. Heart and vessels, 1998, Volume: 13, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Heart Septum; In Vitro Techniques; Lidocaine; Male; Tetrodotoxin; Verapamil	1998
Effects of disopyramide and verapamil on renal disposition and nephrotoxicity of cisplatin in rats. Pharmaceutical research, 1999, Volume: 16, Issue:10 Topics: Animals; Anti-Arrhythmia Agents; Antineoplastic Agents; Area Under Curve; Biotransformation; Blood Urea Nitrogen; Calcium Channel Blockers; Cisplatin; Disopyramide; Kidney; Kidney Diseases; Liver; Male; Platinum; Rats; Rats, Wistar; Stereoisomerism; Verapamil	1999
Enantioselective binding of propranolol, disopyramide, and verapamil to human alpha(1)-acid glycoprotein. Journal of pharmaceutical sciences, 2000, Volume: 89, Issue:6 Topics: Disopyramide; Humans; Orosomucoid; Propranolol; Protein Binding; Stereoisomerism; Verapamil	2000
Cardiovascular action of a cardioselective Ca(2+)channel blocker AH-1058 in conscious dogs assessed by telemetry. European journal of pharmacology, 2001, Feb-09, Volume: 413, Issue:1 Topics: Animals; Atenolol; Blood Pressure; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cardiovascular System; Consciousness; Disopyramide; Dogs; Heart Rate; Hemodynamics; Male; Piperidines; Substrate Specificity; Telemetry; Ventricular Pressure; Verapamil	2001
Role of biantennary glycans and genetic variants of human alpha1-acid glycoprotein in enantioselective binding of basic drugs as studied by high performance frontal analysis/capillary electrophoresis. Pharmaceutical research, 2001, Volume: 18, Issue:3 Topics: Anti-Arrhythmia Agents; Chromatography, Affinity; Chromatography, High Pressure Liquid; Concanavalin A; Copper; Crystallization; Disopyramide; Electrophoresis, Capillary; Humans; Orosomucoid; Polysaccharides; Protein Binding; Stereoisomerism; Verapamil	2001
Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium. Pharmacology, 2002, Volume: 64, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart; Heart Rate; Male; Myocardial Contraction; Pyridines; Verapamil	2002
Deglutition-induced atrial fibrillation. Texas Heart Institute journal, 2005, Volume: 32, Issue:4 Topics: Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Deglutition; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Verapamil	2005
[Drug treatment for hypertrophic cardiomyopathy]. Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Chest Pain; Death, Sudden, Cardiac; Disopyramide; Diuretics; Drug Monitoring; Dyspnea; Embolism; Endocarditis; Heart Failure, Systolic; Humans; Myocardial Ischemia; Patient Selection; Vasodilator Agents; Verapamil	2009
Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline. The American journal of cardiology, 2010, Nov-01, Volume: 106, Issue:9 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Echocardiography, Doppler; Female; Humans; Imidazoles; Lidocaine; Linear Models; Male; Middle Aged; Propranolol; Prospective Studies; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Pressure; Verapamil	2010
Treatment of obstructive hypertrophic cardiomyopathy symptoms and gradient resistant to first-line therapy with β-blockade or verapamil. Circulation. Heart failure, 2013, Volume: 6, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cardiac Surgical Procedures; Cardiomyopathy, Hypertrophic; Combined Modality Therapy; Disopyramide; Female; Humans; Male; Middle Aged; Treatment Failure; Verapamil	2013
Symptomatic obstructive hypertrophic cardiomyopathy. Circulation. Cardiovascular interventions, 2013, Oct-01, Volume: 6, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Cardiomyopathy, Hypertrophic; Diagnosis, Differential; Disease-Free Survival; Disopyramide; Dyspnea; Echocardiography; Echocardiography, Doppler; Female; Heart Septum; Humans; Hypertension; Ventricular Outflow Obstruction; Verapamil	2013