verapamil has been researched along with diphenhydramine in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (19.51) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 15 (36.59) | 29.6817 |
| 2010's | 14 (34.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Hashimoto, N; Nezu Ji, J; Nikaido, H; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A | 1 |
| Keserü, GM | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Sen, S; Sinha, N | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Papadimituiou, JM; Sforcina, D | 1 |
| Hasl, G; Heim, F; Mitznegg, P; Pauly, H; Schubert, E; Sprügel, W | 1 |
| Demling, L; Domschke, S; Domschke, W; Heim, F; Mitznegg, P; Schubert, E; Schwemmle, K; Strunz, U | 1 |
| Mutafova-Yambolieva, V; Staneva-Stoytcheva, D; Todorov, S; Vassilev, P | 1 |
| Farber, HI | 1 |
| Colburn, WA; Eldon, MA | 1 |
| Lui, CY; McCall, D | 1 |
| Shenkman, BZ | 1 |
| Barman, SA; Olson, MD; Saari, JT | 1 |
| Abman, SH; Accurso, FJ; Ward, RM; Wilkening, RB | 1 |
| Ferrara, JJ; Flint, LM; Force, SD; Franklin, EW; Hyman, AL; Lippton, HL; Taheri, PA | 1 |
| Han, YH; Hu, DN; Pritchard, JB; Sweet, DH | 1 |
| Ambu, R; Garau, L; Olianas, MC; Onali, P | 1 |
| Bafor, EE; Nworgu, ZA; Sanni, U | 1 |
| Chen, DP; Diao, YP; Lin, Y; Yao, QY; Ye, DM | 1 |
1 review(s) available for verapamil and diphenhydramine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
40 other study(ies) available for verapamil and diphenhydramine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carnitine; Carrier Proteins; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Tetraethylammonium; Tissue Distribution; Tritium | 2001 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
The effects of drugs on monocytic fusion in vivo.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cell Fusion; Cell Membrane; Cortisone; Cyclic AMP; Diphenhydramine; Edetic Acid; Glucagon; Insulin; Isoproterenol; Lidocaine; Lysosomes; Male; Mice; Mice, Inbred C57BL; Monocytes; Ouabain; Pyrilamine; Tetracaine; Trifluoperazine; Verapamil | 1975 |
Immediate X-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs.
Topics: Acetylcholine; Animals; Atropine; Diphenhydramine; Female; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nicotine; Tetrodotoxin; Time Factors; Verapamil; X-Rays | 1977 |
[Mode of action of bisacodyl (dulcolax) on isolated muscles of human colon (author's transl)].
Topics: Acetylcholine; Bisacodyl; Colon; Cresols; Diphenhydramine; Drug Antagonism; Histamine; Humans; Muscle Contraction; Muscle Tonus; Nicotine; Tetrodotoxin; Verapamil | 1975 |
Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.
Topics: Animals; Calcium; Cimetidine; Dimaprit; Diphenhydramine; Electric Stimulation; Histamine; In Vitro Techniques; Male; Muscle Contraction; Rats; Receptors, Histamine H1; Receptors, Histamine H2; Thiazoles; Thiourea; Vas Deferens; Verapamil | 1991 |
Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly.
Topics: Aged; Diphenhydramine; Humans; Muscle Cramp; Quinine; Verapamil | 1990 |
Influence of absorption rate, dosing frequency, and intrinsic pharmacokinetic profile on steady-state drug concentrations.
Topics: Circadian Rhythm; Diphenhydramine; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Software; Verapamil | 1990 |
The effects of histamine on contraction frequency, sodium influx, and cyclic AMP in cultured rat heart cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Cimetidine; Cyclic AMP; Diphenhydramine; Heart; Histamine; Imines; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1986 |
[Effect of verapamil, cromoglycate and dimedrol on the survivability of mice in endotoxic shock].
Topics: Animals; Cromolyn Sodium; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Endotoxins; Lethal Dose 50; Male; Mice; Shigella sonnei; Shock, Septic; Time Factors; Verapamil | 1987 |
Histamine induced alteration of calcium binding to microvascular endothelium as indicated by use of ionic lanthanum.
Topics: Animals; Binding Sites; Calcium; Capillary Permeability; Cimetidine; Diphenhydramine; Endothelium, Vascular; Female; Histamine; In Vitro Techniques; Lanthanum; Male; Microcirculation; Microscopy, Electron; Rabbits; Verapamil | 1987 |
Adaptation of fetal pulmonary blood flow to local infusion of tolazoline.
Topics: Animals; Blood Pressure; Cimetidine; Diphenhydramine; Female; Fetus; Heart Rate; Phentolamine; Pregnancy; Pulmonary Circulation; Sheep; Tolazoline; Verapamil | 1986 |
Analysis of regional hemodynamic regulation in response to scald injury.
Topics: Adamantane; Animals; Arginine; Atropine; Blood Pressure; Burns; Diphenhydramine; Dogs; Femoral Artery; Hemodynamics; Hindlimb; Histamine; Isoproterenol; Meclofenamic Acid; Methoxamine; Methysergide; Morpholines; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroglycerin; Pulmonary Circulation; Ranitidine; Regional Blood Flow; Ritanserin; Serotonin; Serotonin Receptor Agonists; Time Factors; Triazines; Ultrasonography; Vascular Resistance; Vasodilation; Verapamil; Xanthines | 1994 |
Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells.
Topics: Algorithms; Calcium Channel Blockers; Carrier Proteins; Cells, Cultured; Diphenhydramine; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Pigment Epithelium of Eye; Verapamil | 2001 |
Allosteric modulation of GABA(B) receptor function in human frontal cortex.
Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Calcium; Calcium Channel Blockers; Cell Membrane; Colforsin; Diphenhydramine; Dopamine Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine H1 Antagonists; Humans; Male; Middle Aged; Phenols; Prefrontal Cortex; Receptors, GABA-B; Trifluoperazine; Verapamil | 2005 |
In vitro determination of the mechanism of the uterine stimulatory effect of Newbouldia laevis.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Bignoniaceae; Calcium Channel Blockers; Diphenhydramine; Drug Evaluation, Preclinical; Female; Histamine H1 Antagonists; In Vitro Techniques; Muscarinic Antagonists; Oxytocics; Oxytocin; Phentolamine; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Uterine Contraction; Verapamil | 2010 |
Modulatory effects of taurine on jejunal contractility.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Calcium Channel Blockers; Cimetidine; Diphenhydramine; Enteric Nervous System; Histamine H1 Antagonists; Histamine H2 Antagonists; Jejunum; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Nitric Oxide; Nitric Oxide Synthase; Phentolamine; Phosphorylation; Propranolol; Rats, Sprague-Dawley; Taurine; Tetrodotoxin; Verapamil | 2014 |