verapamil has been researched along with dextromethorphan in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 15 (51.72) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Frotscher, M; Hartmann, RW; Hinsberger, S; Marchais-Oberwinkler, S; Oster, A; Werth, R | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bassetto, M; Brancale, A; Ferla, S; Kandil, S; McGuigan, C; Pertusati, F; Westwell, AD | 2 |
| Albert, DH; Bui, MH; Edalji, RP; Elmore, SW; Faivre, EJ; Fang, G; Fidanze, SD; Gao, W; Hasvold, LA; Huang, X; Hutchins, CW; Kati, WM; Li, L; Lin, X; Liu, D; Magoc, TJ; Mantei, RA; Martin, R; McDaniel, KF; Park, CH; Pratt, JK; Rajaraman, G; Shen, JJ; Shen, Y; Sheppard, GS; Soltwedel, T; Sun, CC; Wang, L; Wang, R; Warder, SE; Wilcox, D; Wong, S | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Chen, D; Goh, WH; Soh, CK; Wang, H | 1 |
| Biggin, PC; Bluck, JP; Bruno, PA; Clayton, J; Conway, SJ; Evans, CNG; Filippakopoulos, P; Guzanov, P; Hammond, EM; Hewings, DS; Hicks, A; Humphreys, PG; Jennings, LE; Laurin, CMC; Mapp, AK; Mistry, IN; Moroglu, M; Picaud, S; Reynolds, JK; Schiedel, M; Scorah, AR; See, L; Stazi, G | 1 |
| Albert, DH; Bui, M; Faivre, E; Fidanze, SD; Hasvold, LA; Huang, X; Kati, WM; Kovar, PJ; Lin, X; Liu, D; Longenecker, K; Magoc, TJ; McDaniel, KF; Park, CH; Pratt, JK; Qiu, W; Rajaraman, G; Shen, Y; Sheppard, GS; Torrent, M; Wang, L; Wilcox, D; Zhang, L | 1 |
| Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J | 1 |
| Kamei, J; Kasuya, Y | 1 |
| Keith, RA; Mangano, TJ; Patel, J; Salama, AI | 1 |
| Abdullah, S; Ducharme, J; Wainer, IW | 1 |
| Block, F; Schwarz, M | 1 |
| Barnas, CR; Gorski, JC; Krecic-Shepard, ME; Schwartz, JB; Slimko, J; Wainer, IW | 1 |
| Calzada, JI; Johnson, DA; Jones, BE; Netland, PA | 1 |
| Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M | 1 |
| Briem, S; Pettersson, B; Skoglund, E | 1 |
| Beaudry, F; Deschênes, JL; Flarakos, T; Gritsas, A; Hage, A; Marier, JF; Seliniotakis, E; Vachon, P | 1 |
| Dickinson, PA; Lennernäs, H; Lundahl, A; Schrickx, JA; Thörn, HA | 1 |
1 review(s) available for verapamil and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for verapamil and dextromethorphan
| Article | Year |
|---|---|
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Topics: Adult; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Glioma; Humans; Male; Middle Aged; Molecular Probes; Oxidoreductases, N-Demethylating; Phenotype; Reproducibility of Results; Spectrometry, Fluorescence; Tamoxifen; Verapamil | 1996 |
27 other study(ies) available for verapamil and dextromethorphan
| Article | Year |
|---|---|
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases.
Topics: Cell Line, Tumor; Drug Design; Drug Stability; Estradiol Dehydrogenases; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Humans; In Vitro Techniques; Microsomes, Liver; Phenols; Placenta; Pregnancy; Structure-Activity Relationship; Thiazoles; Thiophenes | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
Topics: Anilides; Antineoplastic Agents; Benzamides; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Permeability; Phenylthiohydantoin; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Tosyl Compounds | 2016 |
Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Structure-Activity Relationship; Xylenes | 2016 |
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Discovery; Fluorescence Resonance Energy Transfer; Half-Life; Humans; Mass Spectrometry; Mice; Proteins; Proton Magnetic Resonance Spectroscopy; Pyridones; Structure-Activity Relationship; Sulfonamides | 2017 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2018 |
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Topics: Biological Assay; Blotting, Western; Cell Cycle Proteins; Crystallography, X-Ray; Drug Stability; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitory Concentration 50; Ligands; Luciferases; MCF-7 Cells; Molecular Dynamics Simulation; Molecular Structure; Nuclear Proteins; Structure-Activity Relationship; Transcription Factors | 2018 |
Discovery of
Topics: Animals; Cell Cycle Proteins; Drug Discovery; Female; HeLa Cells; Humans; Mice; Mice, SCID; Protein Domains; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridines; Pyrroles; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Antitussive effects of Ca2+ channel antagonists.
Topics: Animals; Antitussive Agents; Calcium Channel Blockers; Capsaicin; Codeine; Cough; Dextromethorphan; Drug Interactions; Drug Synergism; Flunarizine; Guinea Pigs; Male; Morphine; Nifedipine; Verapamil | 1992 |
Inhibition of K(+)-evoked [3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Dextromethorphan; Diltiazem; Hippocampus; Male; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides, Cyclic; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach.
Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; Dextromethorphan; Male; Maze Learning; Memory; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Verapamil; Vitamin E | 1998 |
In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antitussive Agents; Area Under Curve; Breath Tests; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Erythromycin; Female; Humans; Infusions, Intravenous; Linear Models; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Verapamil | 1999 |
Glutamate-induced excitotoxicity in retina: neuroprotection with receptor antagonist, dextromethorphan, but not with calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Cell Death; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Laser Coagulation; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Verapamil | 2002 |
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes | 2003 |
Description and validation of a four-channel staggered LC-MS/MS system for high-throughput in vitro screens.
Topics: Caco-2 Cells; Chromatography, High Pressure Liquid; Dextromethorphan; Humans; Propranolol; Spectrometry, Mass, Electrospray Ionization; Verapamil | 2005 |
Enhancing the uptake of dextromethorphan in the CNS of rats by concomitant administration of the P-gp inhibitor verapamil.
Topics: Animals; Antitussive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Dextromethorphan; Drug Interactions; Enzyme Inhibitors; Male; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil | 2005 |
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Biotransformation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Diclofenac; Gene Expression; Glucuronosyltransferase; Humans; Jejunum; Ketoconazole; Liver; Male; Microsomes, Liver; RNA, Messenger; Species Specificity; Swine; Testosterone; Verapamil | 2011 |