verapamil has been researched along with daunorubicin in 235 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (14.89) | 18.7374 |
| 1990's | 132 (56.17) | 18.2507 |
| 2000's | 54 (22.98) | 29.6817 |
| 2010's | 13 (5.53) | 24.3611 |
| 2020's | 1 (0.43) | 2.80 |
| Authors | Studies |
|---|---|
| Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
| Borchardt, RT; Horie, K; Tang, F | 2 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Burkett, BA; Chan, KF; Chan, TH; Chow, LM; Wong, IL; Zhao, Y | 1 |
| Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Castanys, S; Chávez Orellana, H; Estévez-Braun, A; Gamarro, F; Jiménez-Alonso, S; López, M; Muñoz Martinez, F; Pérez-Lomas, AL; Ravelo, AG | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Kashiwada, Y; Sekiya, M; Takaishi, Y; Taniguchi, M; Xiong, J; Yamagishi, T | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Baumert, C; Günthel, M; Hemmer, M; Hilgeroth, A; Krawczyk, S; Lage, H; Langner, A; Molnár, J; Wersig, T | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bao, XZ; Cai, Y; Cui, ZN; Huang, Z; Li, YS; Liu, GJ; Wang, H; Wang, J; Wang, SJ; Wei, B; Wu, R; Yang, X; Ye, XY; Zhao, DS | 1 |
| Cattan, AR; Davies, SM; Hall, AG; Harris, AL; Hickson, ID; Hoban, PR; Robson, CN | 1 |
| Bachmann, M; Imsiecke, G; Krca, S; Kurelec, B; Müller, WE; Pivcevic, B; Ugarković, D | 1 |
| Beck, WT; Qian, XD | 1 |
| Arias, IM; Gatmaitan, Z; Hsing, S | 1 |
| Broxterman, HJ; Hählen, K; Hongo, T; Huismans, DR; Loonen, AH; Pieters, R; Veerman, AJ | 1 |
| Delmer, A; Helou, C; Marie, JP; Thevenin, D; Zittoun, R | 1 |
| Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA | 1 |
| Dekker, H; Lankelma, J; Spoelstra, EC; Westerhoff, HV | 1 |
| Carpentier, Y; Desoize, B; Gorisse, MC | 1 |
| Belov, L; Davey, MW; Davey, RA; Kidman, AD; Marks, DC | 1 |
| Canaves, JM; Ferragut, JA; Gonzalez-Ros, JM; Soto, F | 1 |
| Ferragut, JA; García-Segura, LM; Gonzalez-Ros, JM; Planells-Cases, R; Soto, F | 1 |
| Demant, EJ; Friche, E; Jensen, PB; Sehested, M | 1 |
| Berman, E; McBride, M | 1 |
| Osann, K; Slater, LM; Sweet, P | 1 |
| Demant, EJ; Friche, E; Hansen, HH; Jensen, PB; Jensen, PS; Sehested, M; Sørensen, BS; Vindeløv, L; Wassermann, K; Westergaard, O | 1 |
| Galski, H; Gottesman, MM; Merlino, GT; Mickisch, GH; Pastan, I | 1 |
| Broxterman, HJ; Dekker, H; Lankelma, J; Schuurhuis, GJ; Spoelstra, EC | 1 |
| Suzuki, H; Tatsuta, T; Tomida, A | 1 |
| Coley, HM; Twentyman, PR; Workman, P | 2 |
| Hreniuk, D; Lenard, J; Wilson, PD | 1 |
| Aiken, PM; Gottesman, MM; Merlino, GT; Mickisch, GH; Pastan, I | 1 |
| Aszalos, A; Currier, SJ; Gottesman, MM; Padmanabhan, R; Pine, PS; Schoenlein, PV; Weaver, JL | 1 |
| Gottesman, MM; Licht, T; Merlino, GT; Mickisch, GH; Pastan, I | 1 |
| Boesch, D; Loor, F; Muller, K; Pourtier-Manzanedo, A | 1 |
| Canaves, JM; Ferragut, JA; Gonzalez-Ros, JM | 1 |
| Hagenbeek, T; Herweijer, H; Nooter, K; Oostrum, R; Sonneveld, P; Valerio, D | 1 |
| Bindslev, N; Demant, EJ; Friche, E; Jensen, PB; Sehested, M; Skovsgaard, T | 1 |
| Demant, EJ; Friche, E; Jensen, PB; Nissen, NN; Sehested, M | 1 |
| Larsson, R; Nygren, P | 1 |
| Daniel, JC; Levy, SB; Slapak, CA | 1 |
| Broxterman, HJ; Dekker, H; Lankelma, J; Spoelstra, EC | 1 |
| Adams, M; Andreeff, M; Berman, E; Clarkson, B; Duigou-Osterndorf, R; Godfrey, L | 1 |
| Crowther, D; Fox, BW; McGown, AT; Murphy, D | 1 |
| Benz, B; Eichelbaum, M; Gekeler, V; Häussermann, K; Schumacher, K | 1 |
| Assaraf, YG; Molina, A; Schimke, RT; Sherwood, SW | 1 |
| de Luise, M; Hu, XF; Martin, TJ; Zalcberg, JR | 1 |
| Cairo, MS; Sender, L; Toy, C; van de Ven, C | 1 |
| Appelt, M; Büchner, T; Eichelbaum, M; Grille, W; Hiddemann, W; Hossfeld, DK; Koslowski, B; Kraft, J; Kuse, R; Quabeck, K | 1 |
| Gottesman, MM; Handler, JS; Horio, M; Pastan, I | 1 |
| Andreeff, M; Haimi, J; Hegewisch, S; Jhanwar, S; Redner, A; Steinherz, P | 1 |
| Perchellet, JP; Satyamoorthy, K | 2 |
| Ayala, P; Orozco, E; Samuelson, J; Wirth, D | 1 |
| Broxterman, HJ; Lankelma, J; Pinedo, HM; Schuurhuis, GJ | 1 |
| Boersma, AW; Herweijer, H; Janssen, AL; Nooter, K; Scheper, RJ; Silbermann, MH | 1 |
| Broxterman, HJ; Joenje, H; Keizer, HG; Lankelma, J; Pinedo, HM; Schoonen, WG; Schuurhuis, GJ; van Rijn, J | 1 |
| Currier, SJ; Gottesman, MM; Konen, PL; Pastan, I; Rutherford, AV; Willingham, MC | 1 |
| Gewirtz, DA; Hall, RE; Yanovich, S | 1 |
| Chin, KV; Currier, SJ; Goldenberg, S; Gottesman, MM; Handler, J; Horio, M; Pastan, I; Williams, C | 1 |
| Bindslev, N; Demant, EJ; Friche, E; Jensen, PB; Sehested, M; Skovsgaard, T; Vindeløv, L | 1 |
| Aoki, N; Maruyama, Y; Murohashi, I; Nara, N | 1 |
| Racker, E; Westcott, D; Wu, LT | 1 |
| Chan, PK; Slater, LM; Sweet, P | 1 |
| Bell, JB; Gore, ME; Maitland, JA; McElwain, TJ; Millar, BC; Selby, PJ; Zuiable, A | 1 |
| Kessel, D | 1 |
| Paul, C; Sundman-Engberg, B; Tidefelt, U | 1 |
| Gupta, R; Gupta, RS; Murray, W | 1 |
| Ahmed, NK; Vasanthakumar, G | 2 |
| Broxterman, HJ; Kaptein, LC; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ | 1 |
| Joneckis, CC; Ordóñez, JV; Ross, DD; Testa, JR; Thompson, BW | 1 |
| Sehested, M; Skovsgaard, T; van Deurs, B; Winther-Nielsen, H | 1 |
| Fox, BW; McGown, A; Poppitt, DG | 1 |
| Murray, SL; Slater, LM; Stupecky, M; Sweet, P; Wetzel, MW | 1 |
| Ashmun, RA; Beck, WT; Cirtain, MC; Look, AT | 1 |
| Iida, H; Tsuruo, T | 1 |
| Krishan, A | 3 |
| Baker, MA; Case, N; Gleyzer, E; Hindenburg, AA; Stewart, VJ; Taub, RN | 1 |
| Cano-Gauci, DF; Riordan, JR | 1 |
| Deurloo, J; Nooter, K; Oostrum, R | 1 |
| Joneckis, CC; Ross, DD; Schiffer, CA | 1 |
| Cardarelli, CO; Cornwell, MM; Gottesman, MM; Pastan, I; Willingham, MC | 1 |
| Friche, E; Nissen, NI; Skovsgaard, T | 1 |
| Gordon, K; Krishan, A; Sauerteig, A; Swinkin, C | 1 |
| DuVall, EM; Murray, SL; Slater, LM; Wetzel, MW; Wisdom, RM | 1 |
| Danø, K; Nissen, NI; Skovsgaard, T | 1 |
| Kessel, D; Wilberding, C | 1 |
| Preston, L; Yanovich, S | 1 |
| Berlion, M; Dieterlen, A; Lucas, C; Marchal, S; Merlin, JL; Poullain, MG; Ramacci, C; Schultz, G | 1 |
| Fine, RL; Harrison, SD; Sachs, CW; Safa, AR | 1 |
| Maare, C; Nielsen, D; Skovsgaard, T | 2 |
| Miller, DS | 1 |
| Ichimura, K; Kashiwagura, T; Kawahara, K; Koike, M; Matsui, W; Takeguchi, N | 1 |
| Cano-Gauci, DF; Riordan, JR; Safa, AR; Seibert, FS | 1 |
| Lucas, C; Marchal, S; Merlin, JL; Paraire, M; Poullain, MG; Ramacci, C | 1 |
| Andolina, M; Arrighini, A; Barisone, E; Brach del Prever, A; Leone, L; Madon, E; Massara, FM; Miniero, R; Saroglia, EM; Soldano, S | 1 |
| Lampidis, TJ; Nguyen-Ba, G; Tapiero, H | 1 |
| Chin-Yee, I; Crowther, MA; Daly, S; Keeney, M; Wright, L | 1 |
| Renfro, JL; Sussman-Turner, C | 1 |
| Senior, AE; Urbatsch, IL | 1 |
| Baccarani, M; Candoni, A; Damiani, D; Marie, JP; Melli, C; Michelutti, A; Michieli, MG; Russo, D; Zhou, DC; Zittoun, R | 1 |
| Doige, CA; Sharom, FJ; Yu, X | 1 |
| Carbone, R; Chen, HX; Dannies, PS; Hochberg, RB; Jancis, EM | 1 |
| Boogaerts, MA; Van Acker, KL; Van Hove, LM | 1 |
| Rutherford, AV; Willingham, MC | 1 |
| Berger, W; Elbling, L; Micksche, M; Rehberger, A; Waldhör, T | 1 |
| Barnhill, MA; Frazier, DL; Jones, E; Lothrop, CD; Lu, X; Mishu, L; Niemeyer, G | 1 |
| Jachez, B; Loor, F | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Mahoney, ME; Ponnathpur, V; Ray, S; Self, S; Tang, C; Tourkina, E | 1 |
| Bear, CE | 1 |
| Dekker, H; Lankelma, J; Pinedo, HM; Spoelstra, EC; Westerhoff, HV | 1 |
| Bourgeois, S; Gruol, DJ; Trotter, J; Zee, MC | 1 |
| Björkholm, M; Gruber, A; Larsson, R; Nygren, P; Peterson, C | 1 |
| Guiral, M; Lankelma, J; Viratelle, O; Westerhoff, HV | 1 |
| Altmayr, F; Andreesen, R; Diddens, H; Rastetter, J; Reichle, A | 1 |
| Boesch, D; Loor, F | 1 |
| Nakamura, T; Ueda, T; Urasaki, Y | 1 |
| Gill, DR; Higgins, CF; Hyde, SC; Kirk, J; Mintenig, GM; Sepulveda, FV; Valverde, MA | 1 |
| Braquet, P; Coulomb, H; Faussat-Suberville, AM; Marie, JP; Principe, P | 1 |
| Chen, WY; Hu, X | 1 |
| Andreeff, M; Godfrey, L; Hegewisch-Becker, S; Maslak, P | 1 |
| Belloc, F; Boiron, JM; Cony-Makhoul, P; Dubosc-Marchenay, N; Dumain, P; Fabères, C; Lacombe, F; Marit, G; Montastruc, M; Puntous, M | 1 |
| Baccarani, M; Cerno, M; Damiani, D; Melli, C; Michelutti, A; Michieli, M | 1 |
| Callaghan, R; Riordan, JR | 1 |
| Lee, EJ; Ordóñez, JV; Ross, DD; Schiffer, CA; Sridhara, R; Wooten, PJ | 1 |
| Twentyman, PR; Wright, KA | 1 |
| Belloc, F; Boiron, JM; Cony-Makhoul, P; Dumain, P; Lacombe, F; Lopez, F; Mahon, FX; Marit, G; Montastruc, M; Puntous, M | 1 |
| Futai, M; Manabe, T; Moriyama, Y; Tashiro, Y; Yoshimori, T | 1 |
| Lankelma, J; Mülder, HS; van Grondelle, R; Westerhoff, HV | 1 |
| Cenacchi, A; Fogli, M; Gamberi, B; Manfroi, S; Ottaviani, E; Tosi, P; Tura, S; Visani, G | 1 |
| Ali-Osman, F; Ishikawa, T | 1 |
| Barrand, MA; Center, MS; Rhodes, T; Twentyman, PR | 1 |
| Dietel, M; Erttmann, R; Looft, G; Reymann, A; Woermann, C | 1 |
| Areström, I; Björkholm, M; Briese, B; Gruber, A; Peterson, C; Vitols, S | 1 |
| Basu, SK; Mukhopadhyay, A; Mukhopadhyay, B | 1 |
| Chihara, K; Kitazawa, F; Nagasawa, K; Natazuka, T; Nomiyama, M; Ohnishi, N; Takara, K; Tsumura, A; Yokoyama, T | 1 |
| Dekker, H; Ghauharali, RI; Lankelma, J; Westerhoff, HV | 1 |
| Broxterman, HJ; Eekman, CA; Feller, N; Lankelma, J; Löwenberg, B; Ossenkoppele, GJ; Pinedo, HM; Schoester, M; Schuurhuis, GJ; Sonneveld, P; Währer, DC | 1 |
| Allouche, M; Bailly, JD; Bordier, C; Come, MG; Duchayne, E; Laurent, G; Mansat, V; Quillet-Mary, A | 1 |
| Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Simon, I | 1 |
| de Vries, EG; Elsinga, PH; Fluks, L; Franssen, EJ; Hendrikse, NH; Vaalburg, W; van der Graaf, WT; Visser, GM; Weemaes, AM | 1 |
| Fernández Puentes, JL; García Grávalos, MD; Quesada, AR | 1 |
| Abderrabi, M; Marchal, S; Merlin, JL | 1 |
| Didier, A; Loor, F; Wenger, J | 1 |
| Kamath, AV; Kwon, Y; Morris, ME | 1 |
| Annable, T; Boni, JP; Citeralla, RV; Collins, KI; Greenberger, LM; Hallett, WA; Kramer, R; Lai, FM; May, MK; Powell, D | 1 |
| Davey, MW; Davey, RA; Hargrave, RM | 1 |
| Algour, N; Ayesh, S; Lyubimov, E; Stein, WD | 1 |
| Rumsby, MG; Warr, JR; Wood, DJ | 1 |
| Fujita, T; Fukuzumi, M; Muranishi, S; Nishimaki, A; Yamada, H; Yamamoto, A | 1 |
| Boezeman, J; de Witte, T; Pennings, A; Raymakers, R; Smeets, M; van de Locht, L; Vierwinden, G; Wessels, H | 1 |
| Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM | 1 |
| Ayesh, S; Shao, YM; Stein, WD | 1 |
| Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D | 1 |
| Litman, T; Nielsen, D; Skovsgaard, T; Stein, WD; Zeuthen, T | 1 |
| Litman, T; Skovsgaard, T; Stein, WD; Zeuthen, T | 1 |
| Masui, H; Sakamoto, K; Wakabayashi, I; Yoshimoto, S | 1 |
| Cayre, A; Finat-Duclos, F; Maublant, J; Moins, N; Verrelle, P | 2 |
| Berger, W; Elbling, L; Micksche, M | 1 |
| Benderra, Z; Manfait, M; Morjani, H; Trussardi, A | 1 |
| Garnier-Suillerot, A; Mankhetkorn, S | 1 |
| Ayesh, S; Litman, T; Stein, WD | 1 |
| den Boer, ML; Henze, G; Janka-Schaub, GE; Kazemier, KM; Pieters, R; Veerman, AJ | 1 |
| Aszalos, A; Weaver, JL | 1 |
| Andrivon, W; Florent, JC; Guillosson, JJ; Monneret, C; Nafziger, J | 1 |
| Ambudkar, SV; Cardarelli, C; Lelong, IH; Zhang, J | 1 |
| deSilva, M; El-Osta, A; Hu, XF; Kantharidis, P; Nadalin, G; Parkin, JD; Slater, A; Wall, DM; Zalcberg, JR | 1 |
| Boyer, JL; Hayes, JH; Rios-Velez, L; Soroka, CJ | 1 |
| de Vries, EG; Eriks-Fluks, L; Franssen, EJ; Hendrikse, NH; Hospers, GA; Vaalburg, W; van der Graaf, WT; Willemsen, AT | 1 |
| Bloem, AC; Lokhorst, HM; Roovers, DJ; van Vliet, M | 1 |
| Garnier-Suillerot, A; Mankhetkorn, S; Teodori, E | 1 |
| de Witte, T; Pennings, AH; Raymakers, RA; Smeets, ME; Vierwinden, G; Wessels, H | 1 |
| Lankelma, J; Westerhoff, HV; Wielinga, PR | 1 |
| Kasimir-Bauer, S; Scheulen, ME; Schröder, JK; Seeber, S | 1 |
| Alvarado de la Barrera, C; Diaz-Borjon, A; Jakez-Ocampo, J; Llorente, L; Richaud-Patin, Y; Ruiz-Argüelles, A | 1 |
| Azevedo, I; Calhau, C; Martel, F | 1 |
| Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E | 1 |
| Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T | 1 |
| Landwojtowicz, E; Seelig, A | 1 |
| Ashman, L; Cole, S; Ferrao, P; Sincock, P | 1 |
| Aszalos, A; Bocsi, J; Ladányi, A; Szende, B | 1 |
| Azevedo, I; Keating, E; Martel, F | 1 |
| Eriksen, J; Litman, T; Maare, C; Nielsen, D; Skovsgaard, T | 1 |
| Anagnostopoulos, N; Androutsos, G; Galanopoulos, A; Kalmantis, T; Meletis, J; Paterakis, G; Rombos, Y; Sagriotis, A; Symeonidis, A; Tiniakou, M; Tsimberidou, AM; Yataganas, X; Zoumbos, N | 1 |
| Kang, W; Weiss, M | 2 |
| Hendrikse, NH; Vaalburg, W | 1 |
| Barik, R; Basu, J; Bhakta, S; Chakrabarti, P; Choudhuri, BS; Kundu, M | 1 |
| Eriksen, J; Friche, E; Maare, C; Nielsen, D; Skovsgaard, T | 1 |
| Barge, RM; Honders, MW; Spoelder, HE; Veuger, MJ; Willemze, R | 1 |
| Kakumoto, M; Kita, T; Kobayashi, H; Nakamura, T; Okamura, N; Okumura, K; Sakaeda, T; Takara, K; Yagami, T | 1 |
| Darling, IM; Kamath, AV; Morris, ME | 1 |
| Litman, T; Skovsgaard, T; Stein, WD | 1 |
| Aubert, D; Bonhomme, A; Millot, JM; Pinon, JM; Sauvage, V | 1 |
| Takeshita, A | 1 |
| Garnier-Suillerot, A; Loechariyakul, P; Saengkhae, C; Salerno, M | 1 |
| Abad-Merin, MJ; Cortés, N; Ferragut, JA; Ferrer-Montiel, A; Masip, I; Messeguer, A; Pérez-Payá, E | 1 |
| Balkay, L; Krasznai, Z; Krasznai, ZT; Márián, T; Szabó-Péli, J; Trón, L | 1 |
| Bazzocchi, IL; Castanys, S; Gamarro, F; Jiménez, IA; Mendoza, CR; Muñoz-Martínez, F | 1 |
| Jollès, B; Laigle, A; Stierlé, V | 1 |
| Drewe, J; Fux, I; Gutmann, H; Kusch-Poddar, M | 1 |
| Leader, JP; O'Donnell, MJ | 1 |
| Ades, S; Gould, CJ; Jones, GK; Levy, SB; Maxfield, LF | 1 |
| Adt, I; Kartha, VB; Kegelaer, G; Krishna, CM; Manfait, M; Rubin, S; Sockalingum, GD | 1 |
| Hayashi, M; Idota, Y; Iida, A; Takizawa, Y; Tomita, M | 1 |
| Asashi, S; Higuchi, T; Katoh, M; Suzuyama, N; Takeuchi, T; Yokoi, T; Yoshitomi, S | 1 |
| Chung, SY; Han, AR; Jang, DS; Jang, JO; Kwon, Y; Lee, HJ; Seo, EK | 1 |
| Hasegawa, H; Kitagawa, S; Nabekura, T; Tachikawa, E; Takahashi, T | 1 |
| Eytan, GD; Katzir, H; Regev, R; Yeheskely-Hayon, D | 1 |
| Gekle, M; Sauvant, C; Thews, O; Wirth, C | 1 |
| Chung, SY; Han, AR; Jung, HJ; Lee, HJ; Nam, JW; Seo, EK; Sung, MK | 1 |
| Chen, SG; Li, GY; Liu, JZ; Wang, CB; Wang, LX; Zhang, B | 1 |
| Chmielewski, J; Emmert, D; Hrycyna, CA; Namanja, HA; Pires, MM | 1 |
| Arnoult, C; Barattin, R; Bourges, K; Boutonnat, J; D'Hardemare, AD; Gerby, B; Hardy, G; Olivares, J; Ronot, X | 1 |
| Imasaka, T; Kaneta, T; Mbuna, J | 1 |
| Bebawy, M; Duke, CC; Duke, RK; Marks, D; Roufogalis, BD; Tran, VH | 1 |
| Ardelli, BF; Dooley, LA; Stitt, LE; Tompkins, JB | 1 |
| Kaur, P; Li, W; Sharma, M | 1 |
| McCormick, JW; Vogel, PD; Wise, JG | 1 |
| Brown, K; Kaur, P; Li, W | 1 |
4 review(s) available for verapamil and daunorubicin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Chemosensitizers counteracting acquired resistance to anthracyclines and vinca alkaloids in vivo. A new treatment principle.
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Carcinoma, Ehrlich Tumor; Daunorubicin; Drug Interactions; Drug Resistance; Leukemia P388; Naphthacenes; Verapamil; Vinca Alkaloids; Vincristine | 1984 |
Imaging of P glycoprotein function in vivo with PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Colchicine; Daunorubicin; Drug Resistance, Multiple; Electrons; Humans; Mice; Neoplasm Proteins; Tomography, Emission-Computed; Verapamil | 2002 |
[Recent advances in the treatment of acute myelogenous leukemia: a view of the new agents].
Topics: Alkyl and Aryl Transferases; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Cyclosporine; Cytarabine; Daunorubicin; Drug Design; Farnesyltranstransferase; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Neoplasm Recurrence, Local; Nucleosides; Oxides; Prognosis; Radioisotopes; Remission Induction; Tetrahydronaphthalenes; Topoisomerase Inhibitors; Tretinoin; Verapamil | 2003 |
2 trial(s) available for verapamil and daunorubicin
| Article | Year |
|---|---|
Effects of verapamil on anthracycline-induced cardiomyopathy: preliminary results of a prospective multicenter trial.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathies; Cytarabine; Daunorubicin; Hemodynamics; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Thioguanine; Verapamil | 1990 |
Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Cyclosporine; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Dyes; Humans; Idarubicin; Inhibitory Concentration 50; K562 Cells; Leukemia, Myeloid, Acute; Male; Rhodamine 123; Time Factors; Treatment Outcome; Verapamil | 2009 |
229 other study(ies) available for verapamil and daunorubicin
| Article | Year |
|---|---|
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection | 2002 |
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine | 2002 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Paclitaxel; Polyethylene Glycols; Structure-Activity Relationship; Vinblastine | 2006 |
New functional assay of P-glycoprotein activity using Hoechst 33342.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors | 2007 |
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoquinones; Crystallography, X-Ray; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Leishmania tropica; Mice; Models, Molecular; Molecular Structure; NIH 3T3 Cells; Parasitic Sensitivity Tests; Phenotype; Stereoisomerism; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Malonates; Morpholines; Triterpenes | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Neoplasms; Structure-Activity Relationship | 2013 |
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Furans; Humans; Molecular Docking Simulation; Paclitaxel; Structure-Activity Relationship; Tetrahydroisoquinolines | 2021 |
Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C.
Topics: Amsacrine; Animals; CHO Cells; Colony-Forming Units Assay; Cricetinae; Daunorubicin; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Gene Expression; Glutathione Transferase; Humans; Hybrid Cells; Infant, Newborn; Mitomycin; Verapamil | 1992 |
Expression of P-glycoprotein gene in marine sponges. Identification and characterization of the 125 kDa drug-binding glycoprotein.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Daunorubicin; Drug Resistance; Gene Expression; Membrane Glycoproteins; Porifera; Verapamil; Vincristine | 1992 |
Photoaffinity substrates for P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Daunorubicin; Drug Resistance; Membrane Glycoproteins; Structure-Activity Relationship; Verapamil; Vinblastine | 1992 |
The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Colchicine; Daunorubicin; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Ileum; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Membrane Glycoproteins; Microvilli; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Temperature; Verapamil | 1992 |
Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Child; Daunorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Membrane Glycoproteins; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myelogenous leukemia (AML).
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cefoperazone; Cyclosporine; Daunorubicin; Humans; Leukemia, Myeloid, Acute; Membrane Glycoproteins; Middle Aged; Mitoxantrone; Stem Cells; Tumor Cells, Cultured; Verapamil | 1992 |
Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Compartmentation; Chloroquine; Daunorubicin; Deoxyglucose; Dinitrophenols; Drug Interactions; Drug Resistance; Energy Metabolism; Ethylmaleimide; Humans; Leukemia; Membrane Glycoproteins; Methylamines; Microscopy, Fluorescence; Monensin; Ouabain; Sodium Azide; Tumor Cells, Cultured; Vanadates; Verapamil | 1992 |
Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane Permeability; Cytosol; Daunorubicin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Membrane Glycoproteins; Mice; Tumor Cells, Cultured; Verapamil | 1992 |
Evaluation of a method for detection of cells with reduced drug retention in solid tumours.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Cell Survival; Chromatography, High Pressure Liquid; Culture Media; Cyclosporine; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Friend murine leukemia virus; Humans; Hydrogen-Ion Concentration; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Mice; Neoplasm Proteins; Neoplasms; Nephelometry and Turbidimetry; Reference Standards; Reproducibility of Results; Treatment Outcome; Tumor Cells, Cultured; Verapamil | 1992 |
The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Coloring Agents; Daunorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Epirubicin; Humans; Membrane Glycoproteins; Tetrazolium Salts; Thiazoles; Trypan Blue; Verapamil; Vinblastine | 1992 |
Rapid kinetics of the interaction between daunomycin and drug-sensitive or drug-resistant P388 leukemia cells.
Topics: Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Drug Resistance; Kinetics; Leukemia P388; Liposomes; Receptors, Drug; Receptors, Immunologic; Spectrometry, Fluorescence; Verapamil | 1992 |
Verapamil reverses the ultrastructural alterations in the plasma membrane induced by drug resistance.
Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Freeze Fracturing; Leukemia P388; Membrane Glycoproteins; Mice; Phenotype; Tumor Cells, Cultured; Verapamil | 1992 |
Relationship of VP-16 to the classical multidrug resistance phenotype.
Topics: Affinity Labels; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Membrane; Cell Nucleus; Daunorubicin; Drug Resistance; Etoposide; Phenotype; Polysorbates; Tumor Cells, Cultured; Verapamil | 1992 |
Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells.
Topics: Cell Division; Daunorubicin; Drug Resistance; Humans; Idarubicin; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Verapamil | 1992 |
Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro.
Topics: Cyclosporine; Daunorubicin; Drug Resistance; Drug Synergism; Humans; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Carcinoma, Small Cell; Colony-Forming Units Assay; Daunorubicin; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Antagonism; Humans; In Vitro Techniques; Lung Neoplasms; Mice; Verapamil | 1991 |
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow; Crosses, Genetic; Daunorubicin; Drug Resistance; Female; Humans; Leukocytes; Male; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Mice, Transgenic; Verapamil | 1991 |
P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Survival; Colonic Neoplasms; Daunorubicin; Drug Resistance; Female; Glycerol; Humans; Membrane Glycoproteins; Mice; Neoplasm Proteins; Ovarian Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1991 |
Novel mechanism of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine in potentiation of antitumor drug action on multidrug-resistant and sensitive Chinese hamster cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane; Cricetinae; Cricetulus; Daunorubicin; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Synergism; Ethylenediamines; Membrane Glycoproteins; Terpenes; Verapamil; Vinblastine | 1991 |
Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Daunorubicin; Drug Resistance; Humans; Lung Neoplasms; Membrane Glycoproteins; Tumor Cells, Cultured; Verapamil | 1991 |
A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Survival; Cricetinae; Cricetulus; Daunorubicin; Detergents; Drug Resistance; Female; Imidazoles; Kinetics; Membrane Glycoproteins; Nifedipine; Ovary; Verapamil | 1991 |
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Renal Cell; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; Genes; Humans; Kidney Neoplasms; Male; Membrane Glycoproteins; Mice; Mice, Transgenic; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Daunorubicin; Doxorubicin; Drug Resistance; Humans; KB Cells; Lasers; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Rhodamine 123; Rhodamines; Transfection; Verapamil | 1991 |
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Tolerance; Intestines; Leukocyte Count; Liver; Membrane Glycoproteins; Mice; Mice, Transgenic; Paclitaxel; Spleen; Verapamil; Vinblastine; Vincristine | 1991 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Flow Cytometry; Leukemia, Experimental; Leukemia, Myeloid; Microscopy, Fluorescence; Quinacrine; Quinidine; Tumor Cells, Cultured; Verapamil | 1991 |
Verapamil prevents the effects of daunomycin on the thermotropic phase transition of model lipid bilayers.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Calorimetry, Differential Scanning; Daunorubicin; Diphenylhexatriene; Fluorescence Polarization; Lipid Bilayers; Liposomes; Thermodynamics; Verapamil | 1991 |
Overexpression of the mdr1 gene in blast cells from patients with acute myelocytic leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin-A.
Topics: Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Drug Resistance; Female; Gene Expression; Humans; Leukemia, Myeloid, Acute; Male; Membrane Glycoproteins; Middle Aged; Verapamil | 1990 |
Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cells, Cultured; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Membrane Glycoproteins; Verapamil; Vincristine | 1990 |
The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cyclosporins; Daunorubicin; Dihydropyridines; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Glycerol; Humans; Intracellular Membranes; Membrane Glycoproteins; Polysorbates; Tritium; Tumor Cells, Cultured; Verapamil | 1990 |
Verapamil and cyclosporin A potentiate the effects of chemotherapeutic drugs in the human medullary thyroid carcinoma TT cell line not expressing the 170 kDa P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Membrane Glycoproteins; Thyroid Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine | 1990 |
Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Kinetics; Leukemia, Experimental; Membrane Glycoproteins; Mice; Mutation; Neoplasm Proteins; Phenotype; Verapamil; Vincristine | 1990 |
Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Daunorubicin; Drug Resistance; Female; Humans; Membrane Glycoproteins; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1990 |
Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype.
Topics: Cell Division; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Phenotype; Tamoxifen; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy.
Topics: Daunorubicin; Epithelium; Female; Humans; Lymphocytes; Ovarian Neoplasms; Time Factors; Verapamil | 1991 |
Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines.
Topics: Daunorubicin; Drug Resistance; Humans; Lymphoma; Protein Binding; Stereoisomerism; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin.
Topics: Animals; Cell Line; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Folic Acid Antagonists; Kinetics; Methotrexate; Ovary; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil | 1990 |
Effect of cyclosporin and verapamil on the cellular kinetics of daunorubicin.
Topics: Cell Line; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Time Factors; Verapamil | 1990 |
Effect of idarubicin and epirubicin on in vitro polymorphonuclear function: diminished superoxide radical formation compared to their parent compounds daunorubicin and doxorubicin.
Topics: Cyclosporins; Daunorubicin; Doxorubicin; Epirubicin; Free Radicals; Humans; Idarubicin; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Superoxides; Verapamil | 1990 |
Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.
Topics: Animals; Biological Transport; Dactinomycin; Daunorubicin; Epithelium; Kidney; Kinetics; Mathematics; Models, Biological; Radioisotope Dilution Technique; Tritium; Verapamil; Vinblastine; Vincristine | 1990 |
A study of multidrug resistance and cell kinetics in a child with near-haploid acute lymphoblastic leukemia.
Topics: Cell Cycle; Chromosome Aberrations; Daunorubicin; Drug Resistance; Haplotypes; Humans; Membrane Glycoproteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil | 1990 |
Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine.
Topics: Animals; Daunorubicin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Palmitoylcarnitine; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Entamoeba histolytica: physiology of multidrug resistance.
Topics: Animals; Colchicine; Cross Reactions; Dactinomycin; Daunorubicin; Drug Resistance; Emetine; Entamoeba histolytica; Verapamil | 1990 |
Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Cell Line; Cyclosporins; Daunorubicin; Drug Resistance; Energy Metabolism; Female; Humans; Lactates; Lactic Acid; Ovarian Neoplasms; Verapamil | 1990 |
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Daunorubicin; DNA; Doxorubicin; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trifluoperazine; Verapamil | 1989 |
Effects of cyclosporin A and verapamil on the intracellular daunorubicin accumulation in Chinese hamster ovary cells with increasing levels of drug-resistance.
Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Immunoblotting; Immunoenzyme Techniques; Ovary; RNA; Verapamil | 1989 |
Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cell Nucleus; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Lung Neoplasms; Membrane Glycoproteins; Superoxide Dismutase; Tumor Cells, Cultured; Verapamil | 1989 |
The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Cell Line; Cell Nucleus; Crystallization; Cytoplasm; Daunorubicin; Drug Resistance; Fluorescent Antibody Technique; Humans; Membrane Glycoproteins; Microscopy, Fluorescence; Microtubules; Transfection; Tubulin; Verapamil; Vinblastine | 1989 |
Characterization of a K562 multidrug-resistant cell line.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Daunorubicin; Drug Resistance; Humans; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Membrane Proteins; Molecular Weight; Phenotype; RNA, Messenger; Verapamil | 1989 |
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Biological Transport; Carrier Proteins; Cells, Cultured; Dactinomycin; Daunorubicin; Dogs; Drug Resistance; Epithelium; Kidney; Membrane Glycoproteins; Pharmaceutical Preparations; Verapamil; Vinblastine; Vincristine | 1989 |
Inhibition of vincristine binding to plasma membrane vesicles from daunorubicin-resistant Ehrlich ascites cells by multidrug resistance modulators.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Membrane; Daunorubicin; Drug Resistance; Polysorbates; Quinidine; Trifluoperazine; Tumor Stem Cell Assay; Verapamil; Vincristine | 1989 |
Effects of verapamil on the cellular accumulation of daunorubicin in blast cells and on the chemosensitivity of leukaemic blast progenitors in acute myelogenous leukaemia.
Topics: Adult; Aged; Cell Survival; Daunorubicin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Male; Middle Aged; Verapamil | 1989 |
Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Nicotinic Acids; Nimodipine; Ovary; Paclitaxel; Pimozide; Verapamil | 1986 |
Cyclosporin A and verapamil enhancement of daunorubicin-produced nucleolar protein B23 translocation in daunorubicin-resistant and -sensitive human and murine tumor cells.
Topics: Animals; Cell Line; Cyclosporins; Daunorubicin; Drug Resistance; Humans; Liver Neoplasms, Experimental; Mice; Nuclear Proteins; Nucleophosmin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil | 1989 |
In vitro studies of ways to overcome resistance to VAMP--high dose melphalan in the treatment of multiple myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cell Survival; Colony-Forming Units Assay; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Melphalan; Methylprednisolone; Multiple Myeloma; Tumor Cells, Cultured; Tumor Stem Cell Assay; Verapamil; Vincristine | 1989 |
Interactions among membrane transport systems: anthracyclines, calcium antagonists and anti-estrogens.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Daunorubicin; Doxorubicin; Drug Resistance; Estrogen Antagonists; Kinetics; Leukemia P388; Mice; Naphthacenes; Nifedipine; Nitrendipine; Tamoxifen; Verapamil | 1986 |
Effects of verapamil on uptake and in vitro toxicity of anthracyclines in human leukemic blast cells.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Body Fluids; Cell Transformation, Neoplastic; Daunorubicin; Doxorubicin; Drug Resistance, Microbial; Drug Synergism; Humans; Intracellular Fluid; Leukemia; Middle Aged; Naphthacenes; Remission Induction; Verapamil | 1988 |
Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line.
Topics: Animals; Antineoplastic Agents; Cricetinae; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; HeLa Cells; Humans; Mice; Mutation; Puromycin; Verapamil | 1988 |
Characterization of daunorubicin resistance in K562 leukemia cells lacking daunorubicin reductase activity.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Cell Line; Cell Survival; Daunorubicin; Drug Resistance; Drug Synergism; Glycoproteins; Humans; Leukemia, Experimental; Time Factors; Verapamil | 1987 |
Induction by verapamil of a rapid increase in ATP consumption in multidrug-resistant tumor cells.
Topics: Adenosine Triphosphate; Animals; Daunorubicin; Drug Resistance; Female; Humans; Hydrolysis; Osmolar Concentration; Ovarian Neoplasms; Phenotype; Tumor Cells, Cultured; Verapamil; Vincristine | 1988 |
Isolation of highly multidrug-resistant P388 cells from drug-sensitive P388/S cells by flow cytometric cell sorting.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Membrane; Cell Separation; Dactinomycin; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Phenotype; Verapamil; Vincristine | 1988 |
Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil.
Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Endocytosis; Exocytosis; Female; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Tumor Cells, Cultured; Verapamil | 1987 |
Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; Pyrazoles; Pyrazolones; Time Factors; Tumor Cells, Cultured; Verapamil | 1987 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Podophyllotoxin; Verapamil; Vincristine | 1986 |
Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil.
Topics: Cell Cycle; Cell Line; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance; Drug Synergism; Flow Cytometry; Humans; Leukemia, Lymphoid; Verapamil; Vinblastine; Vinca Alkaloids; Vincristine | 1986 |
Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells.
Topics: Animals; Cell Line; Cell Survival; Colchicine; Cytochalasin B; Cytochalasin D; Cytochalasins; Daunorubicin; Drug Resistance; Humans; Leukemia; Leukemia P388; Leukemia, Myeloid, Acute; Mice; Verapamil; Vincristine | 1986 |
Flow cytometric monitoring of anthracycline transport in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Daunorubicin; Flow Cytometry; Humans; Lasers; Leukemia P388; Leukemia, Experimental; Mice; Naphthacenes; Verapamil | 1986 |
Effect of verapamil and other agents on the distribution of anthracyclines and on reversal of drug resistance.
Topics: Antibiotics, Antineoplastic; Cell Line; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Naphthacenes; Solubility; Verapamil | 1987 |
Contribution of drug transport and reductases to daunorubicin resistance in human myelocytic cells.
Topics: Adult; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Biological Transport; Cell Line; Daunorubicin; Drug Resistance; Drug Synergism; Humans; Leukemia, Myeloid; Verapamil | 1986 |
Action of calcium antagonists on multidrug resistant cells. Specific cytotoxicity independent of increased cancer drug accumulation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium; Calcium Channel Blockers; Cell Line; Cell Survival; Colchicine; Cricetinae; Daunorubicin; Drug Resistance; Humans; Kinetics; Mice; Nifedipine; Trifluoperazine; Verapamil; Vinblastine | 1987 |
Effects of verapamil on the pharmacokinetics of daunomycin in the rat.
Topics: Animals; Daunorubicin; Female; Half-Life; Rats; Tissue Distribution; Verapamil | 1987 |
Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia.
Topics: Acute Disease; Animals; Bone Marrow; Daunorubicin; Drug Resistance; Humans; In Vitro Techniques; Kinetics; Leukemia; Leukemia P388; Mice; Stimulation, Chemical; Verapamil | 1986 |
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Topics: Biological Transport; Carcinoma; Cell Nucleus; Daunorubicin; Drug Resistance; Humans; KB Cells; Quinidine; Verapamil; Vinblastine; Vincristine | 1986 |
Effect of verapamil on daunorubicin accumulation in Ehrlich ascites tumor cells.
Topics: Animals; Biological Transport, Active; Calcium; Carcinoma, Ehrlich Tumor; Cell Line; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Glucose; Mice; Mice, Inbred Strains; Stimulation, Chemical; Verapamil | 1987 |
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
Topics: Animals; Biological Transport; Cell Line; Chlorpromazine; Daunorubicin; Doxorubicin; Flow Cytometry; Fluorometry; Leukemia P388; Leukemia, Experimental; Mice; Monitoring, Physiologic; Trifluoperazine; Tumor Stem Cell Assay; Verapamil | 1986 |
Verapamil restoration of daunorubicin responsiveness in daunorubicin-resistant Ehrlich ascites carcinoma.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Transformation, Neoplastic; Daunorubicin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Mice; Mice, Inbred BALB C; RNA; Verapamil | 1982 |
Mode of action of calcium antagonists which alter anthracycline resistance.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Cell Line; Daunorubicin; Doxorubicin; Drug Resistance; Leukemia P388; Mice; Naphthacenes; Nifedipine; Nitrendipine; Verapamil | 1984 |
Effects of verapamil on daunomycin cellular retention and cytotoxicity in P388 leukemic cells.
Topics: Animals; Biological Transport; Cell Survival; Daunorubicin; Drug Resistance; Kinetics; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred DBA; Verapamil | 1984 |
Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucleus; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Neoplasm Proteins; Piperidines; Subcellular Fractions; Triazines; Tumor Cells, Cultured; Verapamil | 1995 |
Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Breast Neoplasms; Cell Line; Cell Membrane; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proteins; Rats; Recombinant Proteins; Sphingosine; Substrate Specificity; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Influx of daunorubicin in multidrug resistant Ehrlich ascites tumour cells: correlation to expression of P-glycoprotein and efflux. Influence of verapamil.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Female; Gene Expression Regulation; Glucose; Male; Mice; Mice, Inbred DBA; Sodium Azide; Tumor Cells, Cultured; Verapamil | 1995 |
Daunomycin secretion by killfish renal proximal tubules.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buffers; Cyclosporine; Daunorubicin; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Kidney Tubules, Proximal; Killifishes; Microscopy, Fluorescence; Television; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1995 |
Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Canaliculi; Cyclosporine; Daunorubicin; Drug Resistance; Fluoresceins; Fluorescent Dyes; Fura-2; Liver; Membrane Glycoproteins; Microscopy, Fluorescence; Progesterone; Rats; Signal Processing, Computer-Assisted; Tacrolimus; Verapamil; Vinblastine | 1993 |
Selection and characterization of verapamil-resistant multidrug resistant cells.
Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Daunorubicin; Drug Resistance, Multiple; In Vitro Techniques; Iodobenzenes; Photochemistry; Protein Binding; Verapamil; Vinblastine | 1995 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Humans; Leukemia; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Cyclosporins; Daunorubicin; Doxorubicin; Drug Resistance; Female; Humans; Male; Medulloblastoma; Neoplasms; Neuroblastoma; Osteosarcoma; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil; Vincristine | 1994 |
Cross resistance relevance of the chemical structure of different anthracyclines in multidrug resistant cells.
Topics: Aclarubicin; Animals; Carubicin; Cells, Cultured; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Resistance; Humans; In Vitro Techniques; Mice; Tumor Cells, Cultured; Verapamil | 1994 |
Validation of a single point flow cytometric assay for determining P-glycoprotein activity in multidrug resistant cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Fluorometry; Humans; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil | 1994 |
Heat-shock-stimulated transepithelial daunomycin secretion by flounder renal proximal tubule primary cultures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Cycloheximide; Cyclosporine; Daunorubicin; Epithelial Cells; Epithelium; Flounder; Hot Temperature; Immunohistochemistry; Kidney Tubules, Proximal; Kinetics; Microvilli; p-Aminohippuric Acid; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil; Vinblastine | 1995 |
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Dihydropyridines; Escherichia coli; Lipids; Liver; Proteolipids; Sheep; Verapamil; Vinblastine | 1995 |
MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Gene Amplification; Harringtonines; Homoharringtonine; Humans; Leukemia-Lymphoma, Adult T-Cell; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Proteolipids; Verapamil; Vinblastine | 1993 |
The efflux of anthracyclines in multidrug-resistant cell lines.
Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Mice; Phenotype; Tumor Cells, Cultured; Verapamil | 1993 |
Rapid stimulation of rhodamine 123 efflux from multidrug-resistant KB cells by progesterone.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Drug Resistance; Exocytosis; Fluorescent Dyes; Humans; Membrane Glycoproteins; Membrane Potentials; Mice; Progesterone; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Up-Regulation; Verapamil | 1993 |
Evaluation of flow cytometry for multidrug resistance detection in low resistance K562 cells using daunorubicin and monoclonal antibodies.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Drug Resistance; Flow Cytometry; Gene Expression; Humans; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine | 1993 |
Ultrastructural localization of daunomycin in multidrug-resistant cultured cells with modulation of the multidrug transporter.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Nucleus; Daunorubicin; Drug Resistance; Endoplasmic Reticulum; Fixatives; Formaldehyde; Glutaral; Humans; Lysosomes; Membrane Glycoproteins; Mice; Microscopy, Electron; Microscopy, Fluorescence; Nuclear Envelope; Photochemistry; Verapamil | 1993 |
P-glycoprotein regulates chemosensitivity in early developmental stages of the mouse.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Culture Techniques; Cytochalasin D; Daunorubicin; Doxorubicin; Drug Resistance; Drug Synergism; Embryonic and Fetal Development; Female; Membrane Glycoproteins; Mice; Mitomycin; RNA, Messenger; Verapamil | 1993 |
Effect of multidrug-resistant P-glycoprotein gene expression on chloroaluminum tetrasulfonate phthalocyanine concentration.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Daunorubicin; Drug Resistance; Gene Expression; Indoles; Lasers; Membrane Glycoproteins; Mice; Organometallic Compounds; Radiation-Sensitizing Agents; Transfection; Verapamil | 1993 |
Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Peptides, Cyclic; Tumor Cells, Cultured; Verapamil | 1993 |
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Daunorubicin; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Microtubules; Paclitaxel; Tumor Cells, Cultured; Verapamil | 1994 |
Drugs transported by P-glycoprotein inhibit a 40 pS outwardly rectifying chloride channel.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Membrane; Chloride Channels; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Drug Resistance; Ion Channel Gating; Membrane Glycoproteins; Membrane Potentials; Verapamil; Vinblastine | 1994 |
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Culture Media; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Kinetics; Lung Neoplasms; Membrane Glycoproteins; Models, Biological; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1994 |
Reversal of multidrug resistance by RU 486.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Daunorubicin; Dexamethasone; Drug Resistance; Female; Kinetics; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mifepristone; Phenotype; Puromycin; Structure-Activity Relationship; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Verapamil | 1994 |
A non-P-glycoprotein-mediated mechanism of vincristine transport which is affected by resistance modifiers and present in chemosensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cell Survival; Cells, Cultured; Cyclosporine; Daunorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Gene Expression; Heart; Humans; Leukemia, Experimental; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Membrane Glycoproteins; Myocardium; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
Cooperative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Membrane; Daunorubicin; DNA; Drug Resistance; Female; Humans; Kinetics; Liposomes; Magnesium; Membrane Glycoproteins; Ovarian Neoplasms; Spectrometry, Fluorescence; Tumor Cells, Cultured; Verapamil | 1994 |
Kinetics of daunorubicin transport in Ehrlich ascites tumor cells with different expression of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Carcinoma, Ehrlich Tumor; Carrier Proteins; Daunorubicin; Drug Resistance; Female; Gene Expression; Kinetics; Male; Membrane Glycoproteins; Mice; Mice, Inbred DBA; Tumor Cells, Cultured; Verapamil | 1994 |
Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Immunophenotyping; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Glycoproteins; Neoplasm Proteins; Rhodamine 123; Rhodamines; Verapamil; Vincristine | 1994 |
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Extracellular Space; Leukemia P388; Membrane Glycoproteins; Mice; Molecular Sequence Data; Peptides, Cyclic; Verapamil | 1994 |
Circumvention of daunorubicin resistance by a new tamoxifen derivative, toremifene, in multidrug-resistant cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Chemical Phenomena; Chemistry, Physical; Daunorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Phenotype; Solubility; Toremifene; Tumor Cells, Cultured; Verapamil | 1994 |
Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Line; Chloride Channels; Cyclosporins; Daunorubicin; Drug Resistance; Electrophysiology; Humans; Membrane Glycoproteins; Mice; Nitrobenzoates; Transfection; Verapamil | 1993 |
Flow cytometric monitoring of anthracycline accumulation after anti-neoplastic ether phospholipid treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Interactions; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Leukemia, Myeloid; Leukemia, T-Cell; Phospholipid Ethers; Tumor Cells, Cultured; Verapamil | 1994 |
[Intracellular accumulation, retention, and distribution of anthracyclines in a multidrug-resistant variant K562r].
Topics: Antibiotics, Antineoplastic; Cell Nucleus; Chromatography, High Pressure Liquid; Cytoplasm; Daunorubicin; Doxorubicin; Drug Resistance; Epirubicin; Humans; Leukemia, Erythroblastic, Acute; Tumor Cells, Cultured; Verapamil | 1994 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blast Crisis; Child; Child, Preschool; Daunorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Neoplasm Proteins; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Salvage Therapy; Treatment Failure; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1994 |
Daunorubicin (DNR) accumulation in fresh leukemic cells: correlation with clinical and biological features.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Bone Marrow; Bone Marrow Transplantation; Cytarabine; Daunorubicin; Female; Flow Cytometry; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Stimulation, Chemical; Treatment Failure; Verapamil | 1994 |
D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Survival; Colonic Neoplasms; Daunorubicin; Doxorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Idarubicin; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Tumor Cells, Cultured; Verapamil | 1993 |
Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Membrane; CHO Cells; Cricetinae; Daunorubicin; Drug Resistance; Iodine Radioisotopes; Membrane Glycoproteins; Narcotics; Verapamil; Vinblastine | 1993 |
Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Carrier Proteins; Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance; Female; Humans; Leukemia, Myeloid, Acute; Male; Membrane Glycoproteins; Middle Aged; Tumor Cells, Cultured; Verapamil | 1993 |
Derivation and characterisation of a mouse tumour cell line with acquired resistance to cyclosporin A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinosarcoma; Carrier Proteins; Cyclosporine; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Resistance; Mammary Neoplasms, Experimental; Membrane Glycoproteins; Mice; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
Flow cytometric study of idarubicin and daunorubicin accumulation and the effect of verapamil in leukemic cell lines and fresh cells from patients with acute non-lymphoblastic leukemia.
Topics: Adolescent; Adult; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Time Factors; Tumor Cells, Cultured; Verapamil | 1994 |
ATP-dependent uptake of anti-neoplastic agents by acidic organelles.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Antineoplastic Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; Cells, Cultured; Chromaffin Granules; Daunorubicin; Drug Resistance; Hydrogen-Ion Concentration; Mice; Nigericin; Organelles; Proteolipids; Proton-Translocating ATPases; Quinidine; Reserpine; Valinomycin; Vanadates; Verapamil | 1994 |
A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer.
Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Computer Simulation; Daunorubicin; Diphenylhexatriene; DNA; Drug Resistance; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Models, Biological; Spectrometry, Fluorescence; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors.
Topics: Bone Marrow Cells; Colony-Forming Units Assay; Daunorubicin; Drug Therapy, Combination; Erythroid Precursor Cells; Humans; Leukemia; Leukemia, Myeloid, Acute; Stem Cells; Stereoisomerism; Tumor Stem Cell Assay; Verapamil | 1993 |
Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Chloramphenicol O-Acetyltransferase; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cisplatin; Daunorubicin; DNA, Neoplasm; Doxorubicin; Glutathione; Kinetics; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Biological; Organoplatinum Compounds; Protein Biosynthesis; Protein Synthesis Inhibitors; Rabbits; Reticulocytes; Ribonucleotides; RNA, Messenger; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured; Verapamil | 1993 |
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
Topics: Carcinoma, Non-Small-Cell Lung; Cyclosporine; Cyclosporins; Daunorubicin; Humans; Lung Neoplasms; Membrane Proteins; Molecular Weight; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
Reversal of multidrug resistance in Friend leukemia cells by dexniguldipine-HCl.
Topics: Animals; Cell Division; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Mice; Tumor Cells, Cultured; Verapamil | 1993 |
Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression.
Topics: Adult; Aged; Aged, 80 and over; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Gene Expression; Humans; Leukemia; Male; Middle Aged; Phenotype; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1993 |
Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery.
Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Daunorubicin; Drug Delivery Systems; Drug Resistance, Multiple; Endocytosis; Macrophages; Maleates; Mice; Poly G; Receptors, Drug; Serum Albumin, Bovine; Tumor Cells, Cultured; Verapamil | 1995 |
Heterogeneity of anthracycline retention and response to efflux blockers in human tumors.
Topics: Anthracyclines; Ascites; Breast Neoplasms; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Genetic Heterogeneity; Humans; Verapamil | 1995 |
Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Transport, Active; Blotting, Northern; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genistein; HL-60 Cells; Humans; Isoflavones; Leukemia; RNA, Messenger; RNA, Neoplasm; Temperature; Time Factors; Tumor Cells, Cultured; Verapamil | 1996 |
Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB8-5 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carcinoma, Squamous Cell; Daunorubicin; Drug Resistance, Multiple; Fluorescence; Humans; Kinetics; Mathematics; Spectrometry, Fluorescence; Tumor Cells, Cultured; Verapamil | 1996 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cryopreservation; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Feasibility Studies; Fluorescent Dyes; Humans; Leukemia; Leukemia, Myeloid; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Verapamil; Vincristine | 1996 |
Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Differentiation; Daunorubicin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Methionine Sulfoximine; Nucleosomes; Pyrrolidines; Thiocarbamates; Tumor Cells, Cultured; Verapamil | 1996 |
[Effect of S9788, cyclosporin A and verapamil on intracellular accumulation of doxorubicin, daunorubicin and daunorubicinol in primary rat hepatocyte culture].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Liver; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Verapamil | 1996 |
Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Male; Ovarian Neoplasms; Rats; Rats, Wistar; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured; Verapamil | 1996 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Cricetinae; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia P388; Lung Neoplasms; Mice; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1996 |
Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Leukemia, Experimental; Propylamines; Tumor Cells, Cultured; Verapamil | 1996 |
Decreased uptake of cyclosporin A by P-glycoprotein (Pgp) expressing CEM leukemic cells and restoration of normal retention by Pgp blockers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Flow Cytometry; Humans; Immunosuppressive Agents; Leukemia, Monocytic, Acute; Leukemia, T-Cell; Mice; Peptides, Cyclic; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Inhibitors of P-glycoprotein-mediated daunomycin transport in rat liver canalicular membrane vesicles.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Canaliculi; Biological Transport; Daunorubicin; Male; Propranolol; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
alpha-(3,4-dimethyoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha- [(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile (CL 329,753): a novel chemosensitizing agent for P-glycoprotein-mediated resistance with improved biological properties compared with ver
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Humans; Isoquinolines; Transfection; Tumor Cells, Cultured; Verapamil | 1996 |
Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Calcium Channel Blockers; Cyclosporins; Daunorubicin; Humans; Idarubicin; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1996 |
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Screening Assays, Antitumor; Humans; Kidney; Leukemia P388; Mice; Plasma; Quinidine; Verapamil; Vinblastine | 1996 |
Monensin and verapamil do not alter intracellular localisation of daunorubicin in multidrug resistant human KB cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brefeldin A; Calcium Channel Blockers; Cyclopentanes; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Exocytosis; Golgi Apparatus; Humans; Ionophores; KB Cells; Monensin; Neoplasm Proteins; Subcellular Fractions; Verapamil | 1996 |
Calcein is excreted from the intestinal mucosal cell membrane by the active transport system.
Topics: Animals; Azides; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; In Vitro Techniques; Intestinal Mucosa; Jejunum; Probenecid; Rats; Renal Agents; Sodium Azide; Sodium Fluoride; Verapamil | 1997 |
A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity.
Topics: Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Southern; Cell Division; Daunorubicin; Doxorubicin; Female; Hematopoietic Stem Cells; Humans; Immunohistochemistry; Ovarian Neoplasms; Rhodamines; Tumor Cells, Cultured; Verapamil | 1997 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Mutually co-operative interactions between modulators of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Drug Resistance, Multiple; Drug Synergism; Kinetics; Leukemia P388; Mefloquine; Tamoxifen; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine | 1997 |
ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Ehrlich Tumor; Cell Size; Daunorubicin; Drug Resistance, Multiple; Mice; Tumor Cells, Cultured; Verapamil | 1997 |
Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Enzyme Activation; Gramicidin; Kinetics; Microsomes; Progesterone; Vanadates; Verapamil; Vinblastine | 1997 |
Daunorubicin-induced smooth muscle contraction: involvement of Ca2+ entry mechanism.
Topics: Animals; Antibiotics, Antineoplastic; Calcium; Calcium Channel Blockers; Daunorubicin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Chloride; Trifluoperazine; Verapamil | 1997 |
Comparison between technetium-99m-sestamibi and hydrogen-3-daunomycin myocardial cellular retention in vitro.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genes, MDR; Heart; In Vitro Techniques; Myocardium; Piperidines; Radionuclide Imaging; Rats; Rats, Wistar; Technetium Tc 99m Sestamibi; Triazines; Tritium; Verapamil | 1997 |
Effects of multidrug resistance-related ATP-binding-cassette transporter proteins on the cytoskeletal activity of cytochalasins.
Topics: Actin Cytoskeleton; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Nucleus; Cytochalasins; Cytoskeleton; Daunorubicin; Drug Resistance, Multiple; Humans; Multidrug Resistance-Associated Proteins; Tumor Cells, Cultured; Verapamil | 1997 |
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucleus; Cholesterol; Cytoplasm; Daunorubicin; Drug Resistance, Multiple; Etoposide; Female; Humans; Norsteroids; Proton-Translocating ATPases; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases; Verapamil | 1998 |
The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Idarubicin; Leukemia; Tumor Cells, Cultured; Verapamil | 1998 |
Drug accumulation in the presence of the multidrug resistance pump: dissociation between verapamil accumulation and the action of P-glycoprotein.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Daunorubicin; Drug Resistance, Multiple; Mice; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Survival; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genistein; Humans; In Vitro Techniques; Multidrug Resistance-Associated Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil | 1998 |
Estimation of drug resistance by flow cytometry.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Genistein; Leukemia L5178; Mice; Probenecid; Recombinant Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Verapamil | 1998 |
A new anthracycline with potent anti-leukemic activity overcomes P-glycoprotein multidrug resistance.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; HL-60 Cells; Humans; Tumor Cells, Cultured; Verapamil | 1998 |
Purification and reconstitution of human P-glycoprotein.
Topics: 3T3 Cells; Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, Affinity; Chromatography, Ion Exchange; Clone Cells; Colchicine; Cricetinae; Daunorubicin; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Humans; Indicators and Reagents; KB Cells; Kinetics; Liposomes; Mice; Proteolipids; Recombinant Proteins; Solubility; Transfection; Verapamil; Vinblastine | 1998 |
Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Blotting, Southern; Daunorubicin; Decitabine; Dinucleoside Phosphates; DNA Methylation; Drug Resistance, Multiple; Epirubicin; Exons; Humans; Introns; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Promoter Regions, Genetic; Restriction Mapping; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the Rat.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Bile Canaliculi; Biological Transport; Bucladesine; Cations; Chloroquine; Daunorubicin; Kinetics; Liver; Macrolides; Male; Mitochondrial Proteins; Nocodazole; Rats; Rats, Wistar; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Taurocholic Acid; Verapamil | 1999 |
Comparative 99mTc-sestamibi and 3H-daunomycin uptake in human carcinoma cells: relation to the MDR phenotype and effects of reversing agents.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Humans; Piperidines; Radiopharmaceuticals; Reverse Transcriptase Polymerase Chain Reaction; Technetium Tc 99m Sestamibi; Triazines; Tritium; Tumor Cells, Cultured; Verapamil | 1999 |
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Chemistry; Calcium Channel Blockers; Carcinoma, Small Cell; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Rats; Rats, Nude; Recombinant Fusion Proteins; Tissue Distribution; Tumor Cells, Cultured; Verapamil | 1999 |
Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Idarubicin; Multiple Myeloma; Tumor Cells, Cultured; Verapamil | 1999 |
Partial inhibition of the P-glycoprotein-mediated transport of anthracyclines in viable resistant K562 cells after irradiation in the presence of a verapamil analogue.
Topics: Anthracyclines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytosol; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Humans; Idarubicin; K562 Cells; Photoaffinity Labels; Ultraviolet Rays; Verapamil | 1999 |
Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance.
Topics: Antibiotics, Antineoplastic; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Bone Marrow Cells; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Daunorubicin; Drug Resistance, Multiple; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Idarubicin; Idoxuridine; Leukemia, Myeloid, Acute; Verapamil | 1999 |
The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Cell Compartmentation; Cell Line; Cell Membrane Permeability; Daunorubicin; Digitonin; Doxorubicin; Drug Resistance, Multiple; Epirubicin; Humans; Idarubicin; Kinetics; Verapamil | 2000 |
In vitro effect of multidrug resistance modifiers on idarubicinol efflux in blasts of acute myeloid leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Calcium Channel Blockers; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Idarubicin; Leukemia, Myeloid, Acute; Tumor Cells, Cultured; Verapamil | 2000 |
In vitro flow cytometry method to quantitatively assess inhibitors of P-glycoprotein.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Microscopy, Fluorescence; Tumor Cells, Cultured; Vanadates; Verapamil | 2000 |
Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders. Part II: Increased P-glycoprotein activity in lymphocytes from systemic lupus erythematosus patients might affect steroid requirements for disease control.
Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Count; Daunorubicin; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Flow Cytometry; Genes, MDR; Humans; Lupus Erythematosus, Systemic; Lymphocytes; Male; Monocytes; Prednisone; Severity of Illness Index; Verapamil | 2000 |
Characterization of the transport of the organic cation [3H]MPP+ in human intestinal epithelial (Caco-2) cells.
Topics: 1-Methyl-4-phenylpyridinium; Antibiotics, Antineoplastic; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cations; Daunorubicin; Drug Interactions; Herbicides; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Kinetics; Sodium; Time Factors; Tritium; Verapamil | 2000 |
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine | 2000 |
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine | 2000 |
Monitoring of cellular resistance to cancer chemotherapy: drug retention and efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Calcium Channel Blockers; Cell Membrane Permeability; Chlorpromazine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Mice; Rhodamine 123; Staining and Labeling; Tumor Cells, Cultured; Verapamil | 2001 |
Structure-activity relationship of P-glycoprotein substrates and modifiers.
Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine | 2000 |
Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia.
Topics: Acute Disease; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Death; Cell Survival; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Flow Cytometry; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; RNA, Messenger; Vault Ribonucleoprotein Particles; Verapamil | 2001 |
Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cyclosporins; Daunorubicin; Drug Combinations; Drug Interactions; G2 Phase; Glycerol; Mice; Verapamil | 2001 |
Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cations; Cell Line; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Histidine; Humans; Organic Cation Transport Proteins; Rhodamine 123; Time Factors; Tritium; Tyramine; Verapamil; Vinblastine | 2001 |
Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione; Mice; Neoplasm Proteins; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Stem Cell Assay; Verapamil; Vincristine | 2001 |
Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Transplantation; Calcium Channel Blockers; Carbocyanines; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluoresceins; Fluorescent Dyes; Genistein; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Probenecid; Prognosis; Prospective Studies; Rhodamine 123; Survival Analysis; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2002 |
Influence of P-glycoprotein modulators on cardiac uptake, metabolism, and effects of idarubicin.
Topics: Algorithms; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Heart; Idarubicin; In Vitro Techniques; Male; Myocardium; Rats; Rats, Sprague-Dawley; Stroke Volume; Verapamil | 2001 |
Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis.
Topics: Adenosine Triphosphate; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Bacterial Proteins; Base Sequence; Biological Transport; Calcium Channel Blockers; Cloning, Molecular; Daunorubicin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Escherichia coli; Lipid Metabolism; Molecular Sequence Data; Mycobacterium tuberculosis; Reserpine; Verapamil | 2002 |
Influence of chemosensitizers on resistance mechanisms in daunorubicin-resistant Ehrlich ascites tumour cells.
Topics: Animals; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Carcinoma, Ehrlich Tumor; Cyclosporine; Daunorubicin; DNA Primers; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 2002 |
Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines.
Topics: 2-Chloroadenosine; Alternative Splicing; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Biological Transport; Buthionine Sulfoximine; Calcium Channel Blockers; Cytarabine; Daunorubicin; Decitabine; Deoxyadenosines; Deoxycytidine Kinase; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Humans; Idarubicin; Leukemia; Methotrexate; Neoplasm Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Verapamil | 2003 |
Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital.
Topics: Amiodarone; Animals; Antineoplastic Agents; Daunorubicin; Drug Design; Excitatory Amino Acid Antagonists; Heart; Idarubicin; Kinetics; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Rutin; Time Factors; Vasodilator Agents; Verapamil | 2003 |
Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil.
Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Carbazoles; Carvedilol; Cell Division; Cell Line; Daunorubicin; Digoxin; DNA, Complementary; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epithelial Cells; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Kidney; Paclitaxel; Propanolamines; Swine; Transfection; Verapamil; Vinblastine | 2003 |
Choline uptake in human intestinal Caco-2 cells is carrier-mediated.
Topics: Caco-2 Cells; Carrier Proteins; Choline; Daunorubicin; Humans; Intestinal Mucosa; Intestines; Kinetics; Membrane Transport Proteins; Niacinamide; Sodium; Tetraethylammonium; Time Factors; Verapamil | 2003 |
Pumping of drugs by P-glycoprotein: a two-step process?
Topics: Algorithms; Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cyclosporine; Daunorubicin; Fluoresceins; Humans; Immunosuppressive Agents; Kinetics; Models, Biological; Pharmaceutical Preparations; Quinolines; Verapamil; Vinblastine | 2003 |
P-glycoprotein inhibitors modulate accumulation and efflux of xenobiotics in extra and intracellular Toxoplasma gondii.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Biological Transport, Active; Carbocyanines; Cell Line; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Fluorescent Dyes; Humans; Membrane Transport Proteins; Protozoan Proteins; Toxoplasma; Vacuoles; Verapamil; Xenobiotics | 2004 |
Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclic P-Oxides; Daunorubicin; Glutathione; Humans; Nicotinic Acids; Propionates; Quinolines; Tumor Cells, Cultured; Verapamil | 2004 |
Trimers of N-alkylglycines are potent modulators of the multidrug resistance phenotype.
Topics: Algorithms; Animals; Anthracyclines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Catalysis; Cell Survival; Combinatorial Chemistry Techniques; Daunorubicin; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Mice; Models, Molecular; Multidrug Resistance-Associated Proteins; Oligopeptides; Phenotype; Verapamil | 2005 |
Effects of miltefosine on membrane permeability and accumulation of [99mTc]-hexakis-2-methoxyisobutyl isonitrile, 2-[18F]fluoro-2-deoxy-D-glucose, daunorubucin and rhodamine123 in multidrug-resistant and sensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Daunorubicin; Drug Resistance, Multiple; Fluorodeoxyglucose F18; Humans; Membrane Fluidity; Mice; NIH 3T3 Cells; Phosphorylcholine; Rhodamine 123; Technetium Tc 99m Sestamibi; Verapamil | 2005 |
Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Drug Resistance, Multiple; Humans; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Structure; Plants, Medicinal; Rosaceae; Sesquiterpenes; Structure-Activity Relationship; Transfection; Verapamil | 2005 |
Modulation of MDR1 gene expression in multidrug resistant MCF7 cells by low concentrations of small interfering RNAs.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Daunorubicin; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Fluorescence; Gene Expression; Genes, MDR; Humans; RNA, Messenger; RNA, Small Interfering; Time Factors; Trypan Blue; Verapamil | 2005 |
Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier.
Topics: Adrenergic beta-Antagonists; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillary Permeability; Cell Culture Techniques; Cell Line; Cells, Cultured; Daunorubicin; Endothelium, Vascular; Humans; Models, Biological; Morphine; Narcotics; Propranolol; Sucrose; Swine; Verapamil | 2005 |
Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Drosophila melanogaster; Epithelium; Fluorescent Dyes; Gryllidae; Malpighian Tubules; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Probenecid; Propionates; Quinacrine; Quinolines; Tetraethylammonium; Verapamil | 2005 |
Selection of non-P-glycoprotein mediated high-level etoposide resistant cell lines by adriamycin with P-gp inhibitors.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclosporins; Daunorubicin; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Verapamil | 2006 |
Combined Fourier transform infrared and Raman spectroscopic approach for identification of multidrug resistance phenotype in cancer cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Multidrug Resistance-Associated Proteins; Neoplasms; Phenotype; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Verapamil | 2006 |
Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cardiovascular Agents; Colon; Daunorubicin; Diffusion Chambers, Culture; Fluorescent Dyes; Ileum; Injections, Intravenous; Intestinal Absorption; Jejunum; Male; Rats; Rats, Wistar; Rhodamine 123; Tartrates; Verapamil | 2006 |
Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Daunorubicin; Digoxin; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Quinidine; Rats; Species Specificity; Verapamil | 2007 |
Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Daunorubicin; Drug Resistance, Neoplasm; Humans; Kaempferols; Molecular Structure; Verapamil; Zingiberaceae | 2007 |
Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells.
Topics: Adenosine Triphosphatases; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Cell Membrane; Colchicine; Cyclosporine; Dammaranes; Daunorubicin; Drug Resistance, Neoplasm; Ginsenosides; Humans; Hydrolysis; KB Cells; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship; Triterpenes; Verapamil | 2007 |
Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane.
Topics: Acceleration; Anesthetics; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Excipients; Fluorescence Polarization; Fluorescent Dyes; Humans; K562 Cells; Membrane Fluidity; Rhodamines; Surface-Active Agents; Verapamil | 2007 |
Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell-multilabel counter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Extracts; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Analytical; Daunorubicin; DNA, Neoplasm; Intracellular Space; Male; Prostatic Neoplasms; Rats; Spectrometry, Fluorescence; Subcellular Fractions; Time Factors; Verapamil | 2008 |
Potent modulation of P-glycoprotein activity by naturally occurring phenylbutenoids from Zingiber cassumunar.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclohexenes; Daunorubicin; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Molecular Structure; Rhizome; Verapamil; Zingiberaceae | 2009 |
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Daunorubicin; Dimerization; Doxorubicin; Galantamine; Humans; Inhibitory Concentration 50; Verapamil | 2009 |
Iodination increases the activity of verapamil derivatives in reversing PGP multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Cycle; Cyclosporine; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; K562 Cells; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2010 |
Micellar electrokinetic chromatographic analysis for in vitro accumulation of anthracyclines enhanced by inhibitors of cell membrane transporter-proteins in cancer cells.
Topics: Biological Transport, Active; Cell Line, Tumor; Cellular Structures; Chromatography, Micellar Electrokinetic Capillary; Cyclosporine; Daunorubicin; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Probenecid; Verapamil | 2011 |
Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions.
Topics: Adenosine Triphosphatases; Analysis of Variance; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Survival; Colchicine; Daunorubicin; Drug Resistance, Neoplasm; Flavonoids; Herb-Drug Interactions; Humans; Verapamil; Vinblastine | 2011 |
ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance.
Topics: Animals; Antibiotics, Antineoplastic; Antinematodal Agents; ATP-Binding Cassette Transporters; Brugia malayi; Calcium Channel Blockers; Daunorubicin; Drug Interactions; Drug Resistance; Female; Gene Expression; Macrolides; Male; Microfilariae; Transcription, Genetic; Tubulin Modulators; Verapamil; Vinblastine | 2011 |
The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity.
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Bacterial Proteins; Biological Transport; Daunorubicin; Doxorubicin; Kinetics; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Rifampin; Sequence Homology, Amino Acid; Streptomyces; Vanadates; Verapamil; Vinblastine | 2014 |
Multiple Drug Transport Pathways through Human P-Glycoprotein.
Topics: Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biological Transport; Daunorubicin; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Protein Conformation; Quinolines; Verapamil | 2015 |
Role of Aromatic and Negatively Charged Residues of DrrB in Multisubstrate Specificity Conferred by the DrrAB System of Streptomyces peucetius.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bacterial Proteins; Benzimidazoles; Daunorubicin; Doxorubicin; Drug Resistance, Multiple, Bacterial; Escherichia coli; Ethidium; Evolution, Molecular; Gene Expression; Models, Molecular; Multidrug Resistance-Associated Proteins; Mutation; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Static Electricity; Streptomyces; Structural Homology, Protein; Substrate Specificity; Verapamil | 2017 |