Compounds > verapamil

verapamil and dabigatran

verapamil has been researched along with dabigatran in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Härtter, S; Nehmiz, G; Reilly, P; Sennewald, R1
Hu, ZY; Zhao, Y1
Doki, K; Homma, M; Neuhoff, S; Rostami-Hodjegan, A1
Marathe, P; Rodrigues, AD; Shen, H; Sinz, M; Yao, M; Zhu, M1
De Zwart, L; Evers, R; Yamazaki, S1
Cui, C; Lai, X; Li, H; Liu, D; Sia, JEV; Wu, X; Zhang, F1

Trials

1 trial(s) available for verapamil and dabigatran

ArticleYear
Oral bioavailability of dabigatran etexilate (Pradaxa(®) ) after co-medication with verapamil in healthy subjects.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Biological Availability; Blood Coagulation; Calcium Channel Blockers; Cross-Over Studies; Dabigatran; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Interactions; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Pyridines; Time Factors; Verapamil

2013

Other Studies

5 other study(ies) available for verapamil and dabigatran

ArticleYear
Physiologically based pharmacokinetic modelling and in vivo [I]/K(i) accurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate.
    British journal of pharmacology, 2014, Volume: 171, Issue:4

    Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; beta-Alanine; Clarithromycin; Dabigatran; Digoxin; Dronedarone; Drug Interactions; Humans; Models, Biological; Pyridines; Quinidine; Verapamil

2014
Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.
    CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Dabigatran; Drug Dosage Calculations; Drug Interactions; Humans; Kidney Diseases; Models, Theoretical; Prodrugs; Verapamil

2019
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
    Molecular pharmaceutics, 2019, 09-03, Volume: 16, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Dabigatran; Dogs; Drug Interactions; HEK293 Cells; Humans; Inhibitory Concentration 50; Ketoconazole; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quinidine; Renal Elimination; Transfection; Verapamil

2019
Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo extrapolation for intestinal P-glycoprotein inhibition.
    CPT: pharmacometrics & systems pharmacology, 2022, Volume: 11, Issue:1

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Computer Simulation; Dabigatran; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Intestines; Itraconazole; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Quinidine; Verapamil; Young Adult

2022
Physiologically-based pharmacokinetic modeling to predict drug-drug interactions of dabigatran etexilate and rivaroxaban in the Chinese older adults.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2023, Mar-01, Volume: 182

    Topics: Administration, Oral; Aged; Anticoagulants; ATP Binding Cassette Transporter, Subfamily B, Member 1; China; Clarithromycin; Dabigatran; Drug Interactions; East Asian People; Humans; Rivaroxaban; Verapamil

2023