verapamil has been researched along with cysteine in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Britvan, LJ; Hiserodt, JC; Targan, SR | 1 |
| Clarke, DM; Loo, TW | 10 |
| Finkel, MS; Oddis, CV; Romeo, RC; Salama, G; Shen, L | 1 |
| Apodaca, G; Barondes, SH; Leffler, H; Lindstedt, R; Mostov, KE | 1 |
| Dudman, NP; Fu, WY; Perry, MA; Wang, XL | 1 |
| Büyüknacar, HS; Dikmen, A; Göçmen, C; Onder, S; Resim, S | 1 |
| Bartlett, MC; Clarke, DM; Loo, TW | 5 |
| Brown, S; Dunbar, M; Hughes, C; Klinck, J; Nichols, J; Playle, RC; Winter, A | 1 |
| Bates, JN; Bhopatkar, MY; Lewis, SJ; Walton, TM | 1 |
| Dreker, T; Grissmer, S; Rossokhin, A; Zhorov, BS | 1 |
| Bernkop-Schnürch, A; Iqbal, J; Sakloetsakun, D | 1 |
| Doshi, R; van Veen, HW | 1 |
| Ge, J; Li, LB; Li, N; Li, Y; Zhao, Y | 1 |
| George, AM; Jones, PM | 1 |
| Altenberg, GA; Fendley, GA; Mok, L; Singh, A; Swartz, DJ; Urbatsch, IL; Zoghbi, ME | 1 |
| Gu, Q; Kanungo, J; Robinson, B; Rodgers, J | 1 |
1 review(s) available for verapamil and cysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
29 other study(ies) available for verapamil and cysteine
| Article | Year |
|---|---|
Differential effects of various pharmacological agents on the cytolytic reaction mechanism of the human natural killer lymphocyte: further resolution of programming for lysis and KCIL into discrete stages.
Topics: Calcium; Cyclic AMP; Cysteine; Cytotoxicity, Immunologic; Dimethyl Sulfoxide; Dinoprostone; Dithiothreitol; Humans; Killer Cells, Natural; Mercaptoethanol; Neoplasms, Experimental; Prostaglandins E; Verapamil | 1982 |
Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; Cell Line; Cell Membrane; Consensus Sequence; Cysteine; Enzyme Inhibitors; Ethylmaleimide; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotides; Protein Folding; Recombinant Proteins; Sequence Deletion; Spodoptera; Transfection; Verapamil | 1995 |
Positive inotropic effect of acetylcysteine in cardiomyopathic Syrian hamsters.
Topics: Acetylcysteine; Analysis of Variance; Animals; Cardiomyopathies; Cricetinae; Cysteine; Cystine; Male; Mesocricetus; Myocardial Contraction; Papillary Muscles; Ryanodine; Stimulation, Chemical; Verapamil | 1993 |
Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway.
Topics: Animals; Brefeldin A; Calcimycin; Cell Line; Chromatography, Affinity; Cyclopentanes; Cysteine; Cytosol; Dogs; Electrophoresis, Polyacrylamide Gel; Immunohistochemistry; Kidney; Kinetics; L-Lactate Dehydrogenase; Lectins; Methionine; Methylamines; Molecular Weight; Monensin; Nocodazole; Sulfur Radioisotopes; Temperature; Verapamil | 1993 |
Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Colchicine; Cross-Linking Reagents; Cysteine; DNA, Complementary; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidants; Peptide Fragments; Point Mutation; Recombinant Proteins; Transfection; Verapamil; Vinblastine | 1996 |
Drug-stimulated ATPase activity of human P-glycoprotein requires movement between transmembrane segments 6 and 12.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Humans; Membrane Glycoproteins; Movement; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Transfection; Verapamil; Vinblastine | 1997 |
Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Colchicine; Cysteine; Enzyme Inhibitors; Humans; Mutagenesis, Site-Directed; Sulfhydryl Compounds; Verapamil; Vinblastine | 1997 |
Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Colchicine; Cysteine; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Verapamil; Vinblastine | 1999 |
The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; Cell Line; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Cytoplasm; Disulfides; Enzyme Inhibitors; Humans; Membrane Proteins; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Temperature; Verapamil; Vinblastine | 2000 |
Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cell Membrane; Cysteine; Disulfides; Dithiothreitol; Ethylmaleimide; Humans; Models, Biological; Mutagenesis; Nucleotides; Oxygen; Protein Structure, Tertiary; Sulfhydryl Reagents; Verapamil | 2000 |
Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Calcium Channel Blockers; Colchicine; Cross-Linking Reagents; Cysteine; Humans; Immunoblotting; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Verapamil; Vinblastine | 2000 |
Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cysteine; Drug Resistance, Multiple; Humans; Mesylates; Mutagenesis; Verapamil | 2001 |
Homocysteine attenuates hemodynamic responses to nitric oxide in vivo.
Topics: Acetylcholine; Animals; Arterioles; Blood Pressure; Calcium Channel Blockers; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Femoral Artery; Homocysteine; Male; Nicardipine; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Regional Blood Flow; S-Nitrosothiols; Vasodilator Agents; Verapamil | 2002 |
A possible effect of sulfhydryl reagents on the contractile activity of the rat detrusor muscle.
Topics: Acetylcholine; Animals; Cysteine; Diuretics; Dose-Response Relationship, Drug; Electric Stimulation; Ethacrynic Acid; Ethylmaleimide; Glutathione; In Vitro Techniques; Muscle Contraction; Rats; Rats, Inbred WKY; Sulfhydryl Reagents; Urinary Bladder; Vasodilator Agents; Verapamil | 2002 |
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cell Line; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Models, Chemical; Multidrug Resistance-Associated Proteins; Mutation; Protein Binding; Protein Structure, Tertiary; Rhodamines; Transfection; Verapamil | 2002 |
Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine; Humans; Kidney; Mesylates; Mutagenesis; Protein Structure, Tertiary; Verapamil | 2003 |
Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Calcium Channel Blockers; Cell Line; Colchicine; Cysteine; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Fluoresceins; Fluorescent Dyes; Histidine; Humans; Mesylates; Models, Biological; Models, Chemical; Mutation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rhodamines; Verapamil | 2003 |
Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cell Membrane; Cross-Linking Reagents; Cysteine; Cytoplasm; Disulfides; Electrophoresis, Polyacrylamide Gel; Gene Expression; Humans; Immunoblotting; Models, Molecular; Molecular Structure; Mutagenesis; Oxidation-Reduction; Structure-Activity Relationship; Transfection; Vanadates; Verapamil | 2004 |
The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Buffers; Cell Line; Colchicine; Cyclosporine; Cysteine; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Hydrolysis; Isoleucine; Mesylates; Mutation; Rhodamines; Verapamil; Water | 2004 |
Influence of water chemistry and natural organic matter on active and passive uptake of inorganic mercury by gills of rainbow trout (Oncorhynchus mykiss).
Topics: Amiloride; Animals; Biological Transport; Biological Transport, Active; Cysteine; Dose-Response Relationship, Drug; Edetic Acid; Ethylenediamines; Fresh Water; Gills; Ions; Lanthanum; Mercury; Models, Biological; Nitrilotriacetic Acid; Oncorhynchus mykiss; Ontario; Spectrophotometry, Atomic; Verapamil | 2005 |
Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Cysteine; Diltiazem; Hindlimb; Hydrazines; Male; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; S-Nitrosothiols; Vascular Resistance; Vasodilation; Vasodilator Agents; Verapamil | 2005 |
Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Cysteine; Disulfides; Enzyme Activation; Humans; Mesylates; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Substrate Specificity; Vanadates; Verapamil | 2006 |
Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil?
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cysteine; Humans; Hydrogen Bonding; Kv1.3 Potassium Channel; Molecular Sequence Data; Mutation; Potassium Channel Blockers; Protein Structure, Secondary; Stereoisomerism; Verapamil | 2011 |
Thiomers: Inhibition of cytochrome P450 activity.
Topics: Aryl Hydrocarbon Hydroxylases; Chitosan; Coumarins; Cysteine; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Carriers; Drug Compounding; Drug Delivery Systems; Enzyme Assays; Enzyme Inhibitors; Excipients; Indicators and Reagents; Polymers; Sulfhydryl Compounds; Verapamil | 2011 |
Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP-Binding Cassette Transporters; Bacterial Proteins; Benzimidazoles; Binding Sites; Biological Transport; Cell Membrane; Cysteine; Ethidium; Fluorescence Resonance Energy Transfer; Hydrolysis; Mutation; Protein Binding; Protein Multimerization; Substrate Specificity; Verapamil | 2013 |
Pluronic-poly (acrylic acid)-cysteine/Pluronic L121 mixed micelles improve the oral bioavailability of paclitaxel.
Topics: Acrylic Resins; Administration, Oral; Animals; Area Under Curve; Biological Availability; Cysteine; Drug Carriers; Intestinal Absorption; Male; Micelles; Paclitaxel; Particle Size; Poloxamer; Rats; Rats, Wistar; Verapamil | 2014 |
The Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding Domains.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Cloning, Molecular; Cross-Linking Reagents; Cysteine; Drug Resistance, Multiple, Bacterial; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Nucleotides; Oxidation-Reduction; Protein Multimerization; Protein Structure, Tertiary; Protein Subunits; Sequence Alignment; Sulfhydryl Compounds; Verapamil | 2015 |
Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biological Transport, Active; Bioluminescence Resonance Energy Transfer Techniques; Calcium Channel Blockers; Cysteine; Europium; Hydrolysis; Lipid Bilayers; Mice; Models, Molecular; Mutation; Nanostructures; Protein Conformation; Protein Interaction Domains and Motifs; Protein Refolding; Recombinant Fusion Proteins; Terbium; Verapamil | 2017 |
N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish.
Topics: Acetylcysteine; Animals; Antioxidants; Calcium Channel Blockers; Cardiotoxicity; Cysteine; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Heart Rate; Verapamil; Zebrafish | 2020 |