verapamil has been researched along with cyclosporine in 409 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 183 (44.74) | 18.2507 |
| 2000's | 139 (33.99) | 29.6817 |
| 2010's | 85 (20.78) | 24.3611 |
| 2020's | 2 (0.49) | 2.80 |
| Authors | Studies |
|---|---|
| Atassi, G; Dhainaut, A; Guilbaud, N; Kraus-Berthier, L; Leonce, S; Pierre, A; Regnier, G; Tizot, A | 1 |
| Georges, E; L'Heureux, F; Liu, Z; Pouliot, JF; Prichard, RK | 1 |
| Faussat, AM; Kühnel, JM; Marie, JP; Perrot, JY; Schwaller, MA | 1 |
| Dintaman, JM; Kim, AE; Silverman, JA; Waddell, DS | 1 |
| Achterrath, U; Duflos, M; Emig, P; Fouchard, F; Günther, E; Kutscher, B; Le Baut, G; Menciu, C; Nickel, B; Schmidt, J; Szelenyi, I | 1 |
| Beauwens, R; Boom, A; Golstein, PE; Jacobs, P; Masereel, B; van Geffel, J | 1 |
| Ashworth, P; Brumwell, J; Charlton, P; Chima, L; Dangerfield, W; Folkes, A; Hunjan, S; Pretswell, I; Roe, M; Ryder, H | 1 |
| Choo, EF; Imamura, H; Kim, RB; Leake, B; Wandel, C; Wilkinson, GR; Wood, AJ | 1 |
| Hasegawa, T; Hui, CS; Kitaichi, K; Miyamoto, KI; Sakai, M; Takagi, K; Wang, L; Yokogawa, K | 1 |
| Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL | 1 |
| Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Besterman, JM; Chai, HB; Chávez, D; Cordell, GA; Cui, B; Farnsworth, NR; Kinghorn, AD; Lewis, JA; Lynn, SM; Monks, A; O'Neill, MJ; Pezzuto, JM; Rasoanaivo, P; Silva, GL; You, M | 1 |
| Clarke, R; Ghiorghis, A; Hammer, C; Kim, JH; Kulawiec, RJ; Leonessa, F; Talebian, A | 1 |
| Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Borchardt, RT; Horie, K; Tang, F | 3 |
| Chieli, E; Romiti, N; Tramonti, G | 1 |
| Belinsky, MG; Chen, ZS; Hopper-Borge, E; Kotova, E; Kruh, GD; Shchaveleva, I | 1 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Austin, DJ; Cheng, YC; Jiang, Z; Lee, Y; Liu, SH; Savizky, RM; Yeo, H | 1 |
| Honda, Y; Koyabu, N; Kuwano, M; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Uchiumi, T; Ushigome, F | 1 |
| Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H | 1 |
| Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Porcelli, L; Simone, GM | 1 |
| Go, ML; Liu, XL; Tee, HW | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Globisch, C; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Balsamo, A; Berardi, F; Colabufo, NA; Digiacomo, M; Perrone, R; Rapposelli, S; Vanni, M | 1 |
| Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Simone, GM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Perrone, R | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| Gütschow, M; Häcker, HG; Leyers, S; Wiendlocha, J; Wiese, M | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Globisch, C; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Avdeef, A; Tam, KY | 1 |
| Chow, LM; Jiang, T; Wan, SB; Wong, IL; Yan, CS; Zhang, PY; Zhang, XY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Arefolov, A; Clardy, J; Clarke, AS; Ishihara, K; Marks, KM; Park, ES; Pelish, HE; Ring, JE; Russo, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chan, KF; Chan, TH; Chow, LM; Kan, JW; Wong, IL; Yan, CS | 1 |
| Ambo, A; Minamizawa, M; Nitta, K; Ohkatsu, H; Okada, Y; Sasaki, Y; Sugawara, S; Tsuda, Y; Watanabe, H | 1 |
| Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Barton, P; Ismair, M; Jupp, R; Riley, RJ; Soars, MG | 1 |
| Bastow, KF; Goto, M; Hung, HY; Lee, KH; Nakagawa-Goto, K; Ohkoshi, E | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Biao, WS; Bin, JW; Chow, LM; Hu, X; Jiang, T; Wong, IL; Xing, LF; Yu, ZX | 1 |
| Ballatore, C; Brunden, KR; Cornec, AS; Gay, B; Hoye, AT; Hyde, E; James, MJ; Lee, VM; Lou, K; Smith, AB; Trojanowski, JQ; Yao, Y | 1 |
| Alameh, G; Barret, R; Beltran, S; Cuilleron, CY; de Ravel, MR; Dumontet, C; El Jawad, L; Emptoz-Bonneton, A; Grenot, C; Le Borgne, M; Lomberget, T; Mahiout, Z; Mappus, E; Matera, EL; Melikian, M; Pugeat, M; Rocheblave, L; Walchshofer, N | 1 |
| Chow, LM; Duan, LX; Hu, X; Jiang, T; Li, XM; Liu, T; Liu, Z; Wan, SB; Wang, BC; Wong, IL; Yuan, J; Zhang, XY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chow, LM; Jiang, T; Liu, Z; Peng, K; Wan, SB; Wang, P; Wong, IL; Yang, C | 1 |
| Bignon, J; García Alvarez, MC; Gherbovet, O; Roussi, F | 1 |
| Cui, ZN; Jin, HW; Li, YS; Liao, YX; Liu, XY; Song, GP; Zhao, DS | 1 |
| Chan, KF; Chan, TH; Chow, LMC; Hu, X; Law, MC; Lo, AMY; Wong, ILK; Zhu, X | 1 |
| Carpinella, MC; Gancedo, SN; González, ML; Hodnik, Ž; Kikelj, D; Laiolo, J; Lanza, PA; Peterlin Mašič, L; Tomašič, T; Vera, DMA | 1 |
| Bao, XZ; Cai, Y; Cui, ZN; Huang, Z; Li, YS; Liu, GJ; Wang, H; Wang, J; Wang, SJ; Wei, B; Wu, R; Yang, X; Ye, XY; Zhao, DS | 1 |
| Chow, LMC; Li, FX; Li, P; Liu, Z; Sun, W; Wan, SB; Wang, BC; Wang, XK; Wong, ILK | 1 |
| Cambar, J; L'Azou, B; Lagroye, I; Lakhdar, B; Plande, J | 1 |
| Ar'Rajab, A; Dawidson, IJ | 1 |
| Berland, Y; Chauvet-Monges, AM; Crevat, A; Dussol, B; Elsen, R; Salducci, MD | 1 |
| Fardel, O; Guillouzo, A; Ketterer, B; Loyer, P; Ratanasavanh, D | 1 |
| Delmer, A; Helou, C; Marie, JP; Thevenin, D; Zittoun, R | 1 |
| Cowan, KH; Morrow, CS; Moscow, JA | 1 |
| de Lannoy, IA; Silverman, M | 1 |
| Carpentier, Y; Desoize, B; Gorisse, MC | 1 |
| Bauer, HC; Hegmann, EJ; Kerbel, RS | 1 |
| Akan, H; Beksaç, M; Ertürk, S; Güneyli, A; Ikizünal, Y; Ilhan, O; Koç, H; Sardaş, OS | 1 |
| Artola Urain, T; Campo Hernández, JM; Márquez de Prado Urquía, MM; Sanz Franco, M | 1 |
| Chen, CA; Collins, JL; Herzog, TJ; Mutch, DG | 1 |
| Kim, T; Kishimoto, T; Kumata, N; Kusunose, E; Maekawa, M; Nakatani, T; Ohyama, A; Tsujino, T; Yoshimura, R | 1 |
| Degiannis, D; Hornung, N; Raska, K; Raskova, J | 1 |
| Osann, K; Slater, LM; Sweet, P | 1 |
| Kim, T; Kishimoto, T; Maekawa, M; Maekawa, T; Nakatani, T; Ohyama, A; Sakamoto, W; Tsujino, T; Yoshimura, R | 1 |
| Caracciolo, F; Carulli, G; Grassi, B; Mattii, L; Pardi, C; Petrini, M; Sabbatini, A | 1 |
| Lieberman, KV; Lin, WG; Reisman, L | 1 |
| Boesch, D; Loor, F; Pourtier-Manzanedo, A | 1 |
| Aksentijevich, I; Galski, H; Goldstein, LJ; Gottesman, MM; Mickisch, GH; Pastan, I; Sachs, DH; Schoenlein, PV; Stahle, C | 1 |
| Kawashima, H; Kim, T; Kishimoto, T; Kusunose, E; Maekawa, T; Nakatani, T; Ohyama, A; Sakamoto, W; Tsujino, T; Yoshimura, R | 1 |
| Dawidson, I; Diller, K; Lu, C; Palmer, B; Peters, P; Risser, R; Rooth, P; Sagalowsky, A; Sandor, Z; Seney, F | 1 |
| de Wit, C; Kreft, B; Marre, R; Sack, K | 1 |
| Hartz, PA; Wilson, PD | 1 |
| Aparicio, M; Cambar, J; L'Azou, B; Lakhdar, B; Potaux, L | 1 |
| Naito, M; Nishioka, Y; Ogura, T; Sone, S; Tsuruo, T; Yano, S | 1 |
| Andersen, J; Ashigbi, M; Cassileth, P; Paietta, E; Racevskis, J; Wiernik, PH | 1 |
| Berlion, M; Dieterlen, A; Lucas, C; Marchal, S; Merlin, JL; Poullain, MG; Ramacci, C; Schultz, G | 1 |
| Besenzon, L; Bianchi, M; Brach Del Prever, A; Briccoli, A; Massara, FM; Miniero, R; Picci, P | 1 |
| Bello-Reuss, E; Ernest, S | 1 |
| Miller, DS | 1 |
| Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M | 1 |
| Heike, Y; Koyama, T; Kuroko, C; Naito, M; Tatsuta, T; Tomida, A; Tsuge, H; Tsuruo, T | 1 |
| Chong, AS; Coon, JS; Gebel, HM; Markham, PN | 1 |
| Ichimura, K; Kashiwagura, T; Kawahara, K; Koike, M; Matsui, W; Takeguchi, N | 1 |
| Bates, SE; Dickstein, B; Fojo, AT; Lee, JS; Spolyar, M | 1 |
| Cambar, J; L'Azou, B; Lakhdar, B; Potier, M | 1 |
| Gottesman, MM; Mickisch, GH; Pastan, I | 1 |
| Adler, KM; Brophy, NA; Fisher, GA; Halsey, J; Lum, BL; Sikic, BI; Yahanda, AM | 1 |
| Naito, M; Oh-Hara, T; Tsuge, H; Tsuruo, T; Watanabe, T | 1 |
| Bates, SE; Meadows, BJ; Regis, JI; Robey, RW; Scala, S; Zhan, Z | 1 |
| Delmer, A; Marie, JP; Zhou, D; Zittoun, R | 1 |
| Ling, YH; Perez-Soler, R; Priebe, W; Zou, Y | 1 |
| Lucas, C; Marchal, S; Merlin, JL; Paraire, M; Poullain, MG; Ramacci, C | 1 |
| Gibassier, J; Leclech, G; Lucas, C; Massart, C; Pourquier, P; Raoul, M; Robert, J | 1 |
| Bagnis, C; Bitker, MO; Deray, G; Dubois, M; Jacobs, C; Jacquiaud, C | 1 |
| Reams, GP | 1 |
| Chin-Yee, I; Crowther, MA; Daly, S; Keeney, M; Wright, L | 1 |
| Renfro, JL; Sussman-Turner, C | 1 |
| Fricker, G; Miller, DS; Schramm, U; Wenger, R | 1 |
| Belitsky, P; Knox, MG; Methot, ME; Nicol, D; Sketris, IS | 1 |
| Aksentijevich, I; Cardarelli, CO; Gottesman, MM; Pastan, I | 1 |
| Brezden, CB; Hedley, DW; Rauth, AM | 1 |
| Carozzi, S; Fontana, I; Nasini, MG; Nocera, A; Pietrucci, A; Valente, U | 1 |
| Tsuruo, T | 1 |
| Cambar, J; L'Azou, B; Lakhdar, B; Potaux, L | 1 |
| Coley, HM; Twentyman, PR; Workman, P | 1 |
| Boogaerts, MA; Van Acker, KL; Van Hove, LM | 1 |
| Jachez, B; Loor, F | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Mahoney, ME; Ponnathpur, V; Ray, S; Self, S; Tang, C; Tourkina, E | 1 |
| Bischof, G; Cosentini, EP; Ellinger, A; Hamilton, G; Koperna, T; Riegler, M; Schweitzer, M; Teleky, B; Thalhammer, T; Zacherl, J | 1 |
| Björkholm, M; Gruber, A; Larsson, R; Nygren, P; Peterson, C | 1 |
| Dalton, WS; de Giuli, R; Emerson, S; Lehnert, M; Salmon, SE | 1 |
| Guerci, A; Guerci, O; Humbert, JC; Marchal, S; Merlin, JL; Missoum, N; Ramacci, C; Tsuruo, T | 1 |
| Botling, J; Larsson, R; Liminga, G; Nilsson, K; Nygren, P | 1 |
| Dong, J; Hanaoka, K; Mikami, K; Naito, M; Oh-hara, T; Shirai, A; Tatsuta, T; Tsuruo, T | 1 |
| Gajdzik, L; Graf, J; Stapf, V; Thalhammer, T | 1 |
| Boesch, D; Loor, F | 1 |
| Hever-Szabo, A; Pirity, M; Venetianer, A | 1 |
| Braquet, P; Coulomb, H; Faussat-Suberville, AM; Marie, JP; Principe, P | 1 |
| Cambar, J; L'Azou, B; Lakhdar, B | 1 |
| Ar'Rajab, A; Dawidson, IJ; Harris, RB; Sentementes, JT | 1 |
| Chan, L; Shapiro, JI; Süleymanlar, G; Süleymanlar, I | 1 |
| Crocker, JF; LeVatte, TL; McLellan, DH; Renton, KW | 1 |
| Ar'Rajab, A; Dawidson, IJ; Harris, RB; Mileski, WJ; Sentementes, JT | 1 |
| Cole, SP; Deeley, RG; Fraser, K; Grant, CE; Loe, DW; Sparks, KE; Wilson, GM | 1 |
| Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Robert, J | 1 |
| Elmhorn-Rosenborg, A; Juliusson, G; Paul, C; Peterson, C; Tidefelt, U | 1 |
| Haber, M; Kavallaris, M; Madafiglio, J; Norris, MD | 1 |
| De Bruijn, EA; Durante, NM; Eggermont, AM; Gheuens, EE; Marquet, RL; Van de Vrie, W; Van Oosterom, AT | 1 |
| Adam, Z; Vorlícek, J | 1 |
| Lee, EJ; Ordóñez, JV; Ross, DD; Schiffer, CA; Sridhara, R; Wooten, PJ | 1 |
| Twentyman, PR; Wright, KA | 1 |
| Baumgartner, G; Hamilton, G; Schirmböck, M; Sherwood, ER; Thalhammer, T; Theyer, G | 1 |
| Sakata, A; Tamai, I; Tenda, Y; Terasaki, T; Tsuji, A | 1 |
| Ar'Rajab, A; Dawidson, I; Lu, C; Melone, D; Rossi, P; Wheeler, D | 1 |
| Rooth, P; Shi, CL; Täljedal, IB | 3 |
| Carmichael, J; Harris, AL; Kirk, J; Stratford, IJ | 1 |
| Bischof, G; Cosentini, E; Hamilton, G; Koperna, T; Schiessel, R; Teleky, B; Wenzl, E; Zacherl, J | 1 |
| Degiannis, D; Hornung, N; Luke-Gustites, D; Raska, K; Raskova, J | 1 |
| Hill, BT; Hosking, LK | 1 |
| Choi, JH; Chung, JB; Kim, BS; Kim, HS; Kim, JH; Kwon, OH; Lee, KS; Park, IS; Roh, JK; Yoo, NC | 1 |
| Hong, WS; Kim, CM; Lee, TW; Yang, SW; Youn, DH | 1 |
| Barrand, MA; Center, MS; Rhodes, T; Twentyman, PR | 1 |
| Brown, PA; Heys, SD; Shaikh, MG; Whiting, PH | 1 |
| Belzer, FO; D'Alessandro, AM; Kalayoglu, M; Knechtle, SJ; Pirsch, JD; Reed, A; Roecker, EB; Sollinger, HW | 1 |
| Goldstein, M; Gonwa, TA; Holman, M; Husberg, BS; Klintmalm, GB | 1 |
| Galle, J; Schenck, I; Schollmeyer, P; Wanner, C | 1 |
| Bayazit, Y; Erken, E; Erken, U; Işik, G; Tansuğ, Z; Türkyilmaz, R | 1 |
| Chihara, K; Kitazawa, F; Nagasawa, K; Natazuka, T; Nomiyama, M; Ohnishi, N; Takara, K; Tsumura, A; Yokoyama, T | 1 |
| Eisterer, W; Hilbe, W; Hofmann, J; Ludescher, C; Thaler, J | 1 |
| Ballinger, JR; Boxen, I; Erlichman, C; Ling, V; Sheldon, KM | 1 |
| Gibassier, J; Lucas, C; Massart, C; Pourquier, P; Robert, J | 1 |
| Bártová, V; Hátle, K; Nĕmecek, K; Stípek, S; Zima, T | 1 |
| Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Simon, I | 1 |
| Ferry, DR; Kerr, DJ; Traunecker, H | 1 |
| Caizzi, P; Castagneto, M; Citterio, F; Fioravanti, P; Pozzetto, U; Serino, F | 1 |
| Andreeff, M; Angerler, J; Drach, J; Fiegl, M; Gsur, A; Haberl, I; Hamilton, G; Huber, H; Raderer, M; Zhao, S; Zojer, N | 1 |
| Ogretmen, B; Safa, AR | 1 |
| Hosoya, KI; Kim, KJ; Lee, VH | 1 |
| Deguchi, T; Ehara, H; Kawada, Y; Kawamoto, S; Nezasa, S; Okano, M; Tamaki, M; Yamada, S | 1 |
| Didier, A; Loor, F; Wenger, J | 1 |
| Baumgart, J; Harstrick, A; Scheulen, ME; Schleucher, N; Schroeder, J; Seeber, S; Vanhoefer, U; Wilke, H | 1 |
| Marie, JP; Oudard, S; Pujade Lauraine, E | 1 |
| Aydin, AE; Aygün, S; Carin, M; Cebeci, I; Firatli, E; Güç, U; Kantarci, A; Tanyeri, H; Tuncer, O | 1 |
| Annable, T; Boni, JP; Citeralla, RV; Collins, KI; Greenberger, LM; Hallett, WA; Kramer, R; Lai, FM; May, MK; Powell, D | 1 |
| Daemmrich, J; Heidland, A; Ling, H; Paczek, L; Schaefer, L; Schaefer, RM; Schramm, L; Vamvakas, S | 1 |
| Algour, N; Ayesh, S; Lyubimov, E; Stein, WD | 1 |
| Huang, RN; Lee, TC | 1 |
| Carin, M; Cebeci, I; Firatli, E; Kantarci, A; Tuncer, O | 1 |
| Cabot, MC; Cao, Ht; Geffen, V; Giuliano, AE; Han, TY; Lavie, Y; Lucci, A; Volner, A | 1 |
| Cohen, D; Kokubu, N; Watanabe, T | 1 |
| Chapey, C; Hu, YP; Robert, J | 1 |
| Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D | 1 |
| Cardella, C; Cattran, D; Chan, C; Maurer, J; Pei, Y | 1 |
| Cleary, I; Clynes, M; Connolly, L; Heenan, M; O'Driscoll, L | 1 |
| Bamdad, M; Bohatier, J; Denizeau, F; Grolière, CA; Reader, S | 1 |
| Deshpande, MV; Gooday, GW; O'Donnell, R | 1 |
| Cleary, I; Clynes, M; Doherty, G; Moran, E | 1 |
| Clarke, DM; Loo, TW | 3 |
| Hayes, ML; Joiner, KA; Luft, BJ; Silverman, JA | 1 |
| Cleary, I; Clynes, M; Davies, R; Graves, R; O'Beirne, G; Owen, P | 1 |
| Bertrán, J; García-López, J; Pétriz, J; Sánchez, J | 1 |
| Barrand, MA; Roux, FA; Seetharaman, S; von Weikersthal, SF; Wright, KA | 1 |
| Coelho, AM; Dobbin, JA; Harab, RC; Maia, RC; Rumjanek, VM; Vasconcelos, FC | 1 |
| Hauser, IA; Jakob, I; Lindemann, B; Thévenod, F | 1 |
| Ito, S; Koren, G; Woodland, C | 1 |
| Pestana, M; Serrão, MP; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Abbott, NJ; Begley, DJ; Jezequel, SG; Khan, EU; Reichel, A; Roffey, SJ | 1 |
| Haberl, I; Hamilton, G; Schaufler, K; Swatonek, H; Thalhammer, T; Theyer, G; Ulsperger, E; Wenzl, E | 1 |
| Cowie, FJ; Pinkerton, CR; Pritchard-Jones, K; Renshaw, J | 1 |
| Müller, M; Roninson, I; Sarkadi, B; Szabó, K; Váradi, A; Welker, E | 1 |
| Alex, R; Alsenz, J; Steffen, H | 1 |
| Garnier-Suillerot, A; Mankhetkorn, S | 1 |
| Desai, P; Silver, JG | 1 |
| Béliveau, R; Jetté, L; Murphy, GF | 1 |
| Anderson, R; Jooné, G; Van Rensburg, CE | 1 |
| Lee, VH; Saha, P; Yang, JJ | 1 |
| den Boer, ML; Henze, G; Janka-Schaub, GE; Kazemier, KM; Pieters, R; Veerman, AJ | 1 |
| Elmquist, WF; Fakata, KL; Prince, C; Stemmer, PM; Swanson, SA; Vorce, RL | 1 |
| Hamano, S; Hirose, M; Hosoi, E; Kuroda, Y; Morimoto, M | 1 |
| Aszalos, A; Weaver, JL | 1 |
| Lay, RH; Medh, RD; Schmidt, TJ | 1 |
| Buée-Scherrer, V; Cecchelli, R; Dehouck, MP; Descamps, L; Duhem, C; Fenart, L; Poullain, MG | 1 |
| Andreassi, MG; Andreini, B; Biagini, A; Colombo, MG; De Pietro, S; Del Ry, S; Filippi, C; Giannessi, D; Giovannini, L; Migliori, M; Palla, R; Panichi, V; Taccola, D | 1 |
| Hauser, IA; Hopfer, U; Koziolek, M; Thévenod, F | 1 |
| Hanibuchi, M; Parajuli, P; Shrivastava, P; Sone, S; Tsuruo, T; Yano, S | 1 |
| Erdem, SR; Tuncer, M; Yaşar, U | 1 |
| de Giuli, R; Lehnert, M; Twentyman, PR | 1 |
| Akkaya, V; Ark, E; Ecder, T; Sever, MS; Türk, S; Türkmen, A; Yildiz, A | 1 |
| Chan, MW; Chiang, CD; Song, EJ; Yang, VC | 1 |
| Matha, V; Podsiadlowski, L; Vilcinskas, A | 1 |
| Chan, L; Jacob, LP; Malhotra, D; Shapiro, JI | 1 |
| Ishizuka, H; Kawahara, Y; Kuwano, M; Matsuo, H; Matsuzaki, J; Miyama, T; Naito, M; Sawada, Y; Takanaga, H; Tsuruo, T; Yamamoto, C | 1 |
| Ballinger, JR; Tannock, IF; Tunggal, JK | 1 |
| de Vries, EG; Eriks-Fluks, L; Franssen, EJ; Hendrikse, NH; Hospers, GA; Vaalburg, W; van der Graaf, WT; Willemsen, AT | 1 |
| Choi, CH; Jeong, JH; Kee, KH; Kim, HS; Lim, DY; Min, YD; Park, YH; Rha, HS | 1 |
| Averill-Bates, D; Beaulieu, E; Béliveau, R; Demeule, M; Laplante, A; Sepehr-Araé, A; Wenger, RM | 1 |
| Leist, M; Nicotera, P; Volbracht, C | 1 |
| Baccarani, M; Baraldo, M; Damiani, D; Ermacora, A; Fanin, R; Furlanut, M; Michieli, M; Pea, F; Russo, D | 1 |
| Alvaro, D; Benedetti, A; Bini, A; Delle Monache, MD; Di Cosimo, E; Fraioli, F; Francia, C; Gigliozzi, A; Jezequel, AM; Marucci, L; Papa, E | 1 |
| Friedmann, JM; Hauser, IA; Katsen, AD; Thévenod, F | 1 |
| Kim, SB; Lee, SK; Park, JS; Park, JY; Park, SK; Yang, WS; Yu, ES | 1 |
| Chen, KG; Cohen, D; Durán, GE; Lacayo, NJ; Sikic, BI | 1 |
| Akinci, OF; Aslan, O; Coskun, A; Kocyigit, A; Uzunköy, A | 1 |
| Stewart, BH; Whitfield, LR; Wu, X | 1 |
| Medina, J; Wolf, A | 1 |
| Hoshino, N; Minouchi, T; Morimoto, J; Shibata, N; Yamaji, A | 1 |
| Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E | 1 |
| Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T | 1 |
| Koski, T; Vilpo, J; Vilpo, L | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC | 1 |
| Krca, S; Kurelec, B; Pivcević, B; Sauerborn, R; Smital, T | 1 |
| Ikegawa, T; Koyabu, N; Morimoto, S; Naito, M; Ohtani, H; Sawada, Y; Shoyama, Y; Tsuruo, T; Ushigome, F | 1 |
| Leitch, GJ; Scanlon, M; Shaw, A; Visvesvara, GS | 1 |
| Landwojtowicz, E; Seelig, A | 1 |
| Clarke, R; Leonessa, F; Lu, L; Wainer, IW | 1 |
| Dreisbach, AW; Kusus, M; Lertora, JJ; Simon, EE; Stapleton, DD | 1 |
| Murakami, T; Nagai, J; Nasu, R; Sanemasa, M; Takano, M; Yumoto, R | 1 |
| Arceci, R; Cianfriglia, M; Goda, K; Mechetner, E; Nagy, H; Szabó, G | 1 |
| Ashman, L; Cole, S; Ferrao, P; Sincock, P | 1 |
| Benet, LZ; Lantz, MV; Parasrampuria, DA | 1 |
| de Bruijn, P; de Jonge, MJ; Kurihara, M; Nishiyama, M; Sparreboom, A; Takano, H; Verweij, J; Yamamoto, W | 1 |
| Azevedo, I; Keating, E; Martel, F | 1 |
| Melera, PW; Song, J | 1 |
| Batetta, B; Dessì, S; Diana, A; Diaz, G; Falchi, AM; Gremo, F; Isola, R; Pani, A | 1 |
| Auchère, D; Banide, H; Farinotti, R; Lacour, B; Leroy, C; Tardivel, S; Veau, C | 1 |
| Couette, S; Fernandes, I; Friedlander, G; Prié, D; Silve, C | 1 |
| Hirsch-Ernst, KI; Kahl, GF; Rustenbeck, I; Ziemann, C | 1 |
| Cohen, D; Uchiyama-Kokubu, N; Watanabe, T | 1 |
| Braunstein, G; Davison, AK; Feranchak, AP; Fitz, JG; Lomri, N; Mechetner, E; Roman, RM; Schwiebert, EM; Simeoni, LA | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Liu, GQ; Liu, XD | 1 |
| Droulle, L; Fricker, G; Fricker, S; Graeff, C; Miller, DS | 1 |
| Horie, T; Masubuchi, Y; Nakayama, S | 1 |
| Crowe, A | 1 |
| Farrell, RJ; Keates, AC; Kelly, CP; Menconi, MJ | 1 |
| He, L; Liu, GQ | 1 |
| Dai, H; Luo, S; Peng, A; Yin, A | 1 |
| Landwojtowicz, E; Nervi, P; Seelig, A | 1 |
| Eriksen, J; Friche, E; Maare, C; Nielsen, D; Skovsgaard, T | 1 |
| Lyons, JG; Zheng, G | 1 |
| Dietz, A; Geiger, H; Gossmann, J; Kachel, HG; Kramer, W; Mondorf, U; Scheuermann, EH | 1 |
| Egawa, Y; Miyamoto, K; Sadzuka, Y; Sawanishi, H; Sonobe, T | 1 |
| Buesen, R; Jacob, J; Lampen, A; Mock, M; Nau, H; Seidel, A | 1 |
| Fawcett, JP; Liu, XD; Pan, GY; Wang, GJ; Xie, YY | 1 |
| Chanteux, H; Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F | 1 |
| Hayashi, R; Hirohashi, S; Ino, Y; Kondo, T; Mori, Y; Naishiro, Y; Takada, M; Yamada, T | 1 |
| Dey, S; Hafkemeyer, P; Maki, N | 1 |
| Fox, DA; Harris, JB; He, L; Medrano, CJ; Poblenz, AT | 1 |
| Funakoshi, S; Kiribayashi, Y; Murakami, T; Takano, M; Yumoto, R | 1 |
| Balkay, L; Galuska, L; Goda, K; Juhász, I; Krasznai, Z; Márián, T; Mikecz, P; Nagy, H; Szabó, G; Szincsák, N; Trón, L | 1 |
| Beyer, TD; Dumitriu, IE; Gaipl, US; Herrmann, M; Kalden, JR; Roedel, F | 1 |
| Litman, T; Skovsgaard, T; Stein, WD | 1 |
| Crowe, A; Wong, P | 1 |
| Dawidson, I; Lu, C; Palmer, B; Peters, P; Risser, R; Rooth, P; Sagalowsky, A; Sandor, Z | 1 |
| Aubert, D; Bonhomme, A; Millot, JM; Pinon, JM; Sauvage, V | 1 |
| Maia, RC; Marques-Santos, LF; Oliveira, JG; Rumjanek, VM | 1 |
| Takeshita, A | 1 |
| Fang, X; Sha, X | 1 |
| Andoh, TF; Bennett, WM; Safirstein, R; Saggi, SJ | 1 |
| Dohgu, S; Higuchi, S; Katamine, S; Kataoka, Y; Naito, M; Niwa, M; Sawada, Y; Shirabe, S; Takata, F; Tsuruo, T; Yamauchi, A | 1 |
| Aguilar, P; Muñoz Díaz, AB | 1 |
| Bartlett, MC; Clarke, DM; Loo, TW | 2 |
| Liu, GQ; Yang, ZY | 1 |
| Fang, XL; Sha, XY; Wu, YJ | 1 |
| Balkay, L; Esik, O; Galuska, L; Hernádi, Z; Krasznai, Z; Krasznai, ZT; Márián, T; Szabó, G; Szabó-Péli, J; Trón, L | 1 |
| Collier, AC; Link, JM; Mankoff, DA; Muzi, M; Sasongko, L; Shoner, SC; Unadkat, JD; Yang, X | 1 |
| He, Y; Zeng, S | 1 |
| Collier, AC; Hsiao, P; Link, JM; Mankoff, DA; Muzi, M; Sasongko, L; Unadkat, JD | 1 |
| Achiwa, K; Aungst, BJ; Kobayashi, M; Oda, M; Saikachi, Y; Saitoh, H; Tadano, K; Takahashi, Y; Yamaguchi, M; Yuhki, Y | 1 |
| Barth, A; Braun, J; Müller, D | 1 |
| Anglicheau, D; Beaune, P; Cassinat, B; Legendre, C; Marquet, P; Méria, P; Pallet, N; Rabant, M; Thervet, E | 1 |
| Ejsing, TB; Hasselstrøm, J; Linnet, K | 1 |
| Bergström, M; Blomquist, G; Eriksson, O; Hammarlund-Udenaes, M; Höglund, AU; Långström, B; Roman, M; Sprycha, M; Syvänen, S | 1 |
| Carfi', M; Corsini, E; Gennari, A; Gribaldo, L; Hartung, T; Malerba, I; Pallardy, M; Pieters, R; Van Loveren, H; Vohr, HW | 1 |
| Asashi, S; Higuchi, T; Katoh, M; Suzuyama, N; Takeuchi, T; Yokoi, T; Yoshitomi, S | 1 |
| Moaddel, R; Wainer, IW | 1 |
| He, J; Liu, XL; Peng, WX; Song, J; Tang, J; Xu, P | 1 |
| Berkessel, A; Hescheler, J; Hippler-Altenburg, R; Kamisetti, N; Mariappan, D; Sachinidis, A; Schwengberg, S; Seelig, B | 1 |
| Komar, AA | 1 |
| Ambudkar, SV; Calcagno, AM; Gottesman, MM; Kim, IW; Kimchi-Sarfaty, C; Oh, JM; Sauna, ZE | 1 |
| Hendrikse, NH; Ishiwata, K; Kawamura, K; Yanai, K | 1 |
| Bermejo, M; Casabó-Alós, VG; Fernández-Teruel, C; Garrigues, TM; González-Alvarez, I; Polli, JE; Ruiz-García, A | 1 |
| Amioka, K; Ejiri, M; Kushihara, H; Kuzuya, T; Nabeshima, T; Nitta, A | 1 |
| Hasegawa, H; Kitagawa, S; Nabekura, T; Tachikawa, E; Takahashi, T | 1 |
| Bailey, B; Beck, WT; Bence, AK; Chu, S; Erickson, LC; Erickson, PA; Montrose, MH; Shen, F; Xue, X | 1 |
| Griffin, BT; O'Driscoll, CM | 1 |
| Ackerley, C; Clarke, DM; De Rosa, MF; Ito, S; Lingwood, C; Wang, B | 1 |
| Bui, T; Ho, RJ; Hsiao, P; Unadkat, JD | 1 |
| Boldt, A; Dhein, S; Doll, N; Duerrschmidt, N; Haefliger, JA; Mohr, FW; Pfannmüller, B; Rojas-Gomez, D; Scheffler, A; Scholl, A; Schulte, JS | 1 |
| Liu, HY; Liu, X; Liu, XD; Liu, YC; Wang, GJ; Xie, L; Yang, HW; Zhang, DM | 1 |
| de Vries, EF; Dierckx, RA; Doorduin, J; Klein, HC; van Waarde, A; Vellinga, NA | 1 |
| Chen, SG; Li, GY; Liu, JZ; Wang, CB; Wang, LX; Zhang, B | 1 |
| Bi, ZM; Li, P; Qi, LW; Wang, W; Wen, XD; Wu, Q; Yi, L | 1 |
| Barletta, J; Bergström, M; Blomquist, G; Långström, B; Syvänen, S | 1 |
| Bailey, JG; Coyne, CP; Ross, MK | 1 |
| Chen, X; Gu, Y; Liang, J; Zhou, L | 1 |
| He, L; Ji, BS | 1 |
| Collier, AC; Link, JM; Mankoff, DA; Muzi, M; Sasongko, L; Shoner, S; Unadkat, JD | 1 |
| Li-Blatter, X; Nervi, P; Seelig, A | 1 |
| Chen, L; Chen, YX; Davey, AK; Liu, XQ; Wang, JP; Yang, J | 1 |
| Hayashi, M; Kishimoto, H; Takizawa, Y; Tomita, M | 1 |
| Chung, FS; Eyal, S; Hsiao, P; Kaddoumi, A; Link, JM; Mankoff, DA; Muzi, M; O'Sullivan, F; Unadkat, JD | 1 |
| Kwatra, D; Luo, S; Mitra, AK; Pal, D; Paturi, KD; Shah, SJ | 1 |
| Arnoult, C; Barattin, R; Bourges, K; Boutonnat, J; D'Hardemare, AD; Gerby, B; Hardy, G; Olivares, J; Ronot, X | 1 |
| Dai, Y; Li, F; Li, Y; Wong, ST; Xia, X; Yang, J; Zhou, X | 1 |
| Barata, C; Faria, M; Luckenbach, T; Navarro, A; Piña, B | 1 |
| Cabot, MC; Chapman, JV; Gouazé-Andersson, V | 1 |
| Carsetti, R; D'Amelio, R; Diamanti, AP; Germano, V; Giorda, E; Laganà, B; Podestà, E; Rosado, M; Scarsella, M | 1 |
| Imasaka, T; Kaneta, T; Mbuna, J | 1 |
| Furubayashi, T; Hidalgo, IJ; Katsumi, H; Sakane, T; Shingaki, T; Yamamoto, A; Yamashita, S | 1 |
| Gao, C; Jiang, J; Qiu, F; Tan, Y; Zhang, X | 1 |
| Bosia, A; Corsetto, PA; Costamagna, C; Enrico, E; Ghigo, D; Kopecka, J; Montorfano, G; Riganti, C; Rizzo, AM; Voena, C | 1 |
| Bernstein, D; Berry, G; Fajardo, G; Mochly-Rosen, D; Wong, LJ; Zhao, M | 1 |
| Gao, S; Hu, M; Jiang, Z; Teng, Y; Wang, J; Wu, B; Yang, Z; Yin, T; You, M | 1 |
| Cai-Hong, Z; Fang, M; Jin-Hua, J; Li, H; Ning, W; Qing-Duan, W; Xiao-Juan, G; Yan, Z | 1 |
| Gieseg, SP; Whiteman, M; Yang, YT | 1 |
| Greenberg, RM; Kasinathan, RS; Morgan, WM | 1 |
| Clarke, G; Cryan, JF; Dinan, TG; Fitzgerald, P; Griffin, BT; O'Brien, FE | 1 |
| Du, GH; Mei, C; Qi, Y; Sun, X; Sun, XB; Yang, ZH | 1 |
| Be, X; Berry, L; Chen, A; Huang, L; Janosky, B; Lin, MH; Roberts, J | 1 |
| Jakob, I; Molinas, A; Sicard, G | 1 |
| Caritis, SN; Dorko, K; Ellis, EC; Gramignoli, R; Hansel, M; Hines, RN; Mattison, DR; Sharma, S; Strom, SC; Tahan, V; Venkataramanan, R | 1 |
| Gao, S; Hu, M; Liu, W; Liu, Z; Wang, F; Yang, X; Yang, Z; Ye, L; Yin, T | 1 |
| Swartz, DJ; Urbatsch, IL; Weber, J | 1 |
| Chung, FS; Eyal, S; Ke, AB; Link, JM; Mankoff, DA; Muzi, M; Unadkat, JD | 1 |
| Li, Z; Liu, F; Ruan, J; Yang, C; Zhang, T; Zhang, Z | 1 |
| Ambudkar, SV; Ansbro, MR; Li, L; Shukla, S; Yuspa, SH | 1 |
| Clarke, G; Cryan, JF; Dinan, TG; Griffin, BT; O'Brien, FE; O'Connor, RM | 1 |
| Zarbin, MA | 1 |
| Liu, L; Liu, X; Sai, Y; Wang, D; Wang, J; Xia, S; Xue, W | 1 |
| Huo, X; Liu, K; Liu, Q; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C | 1 |
| Junco, JJ; Kim, DJ; Liang, H; Malik, G; Mancha, A; Slaga, TJ; Wei, SJ | 1 |
| Ahmadi, F; Mohammadi-Samani, S; Montaseri, H; Sobhani, Z; Zarea, B | 1 |
| Li, Z; Liu, F; Liu, K; Ruan, J; Xu, L; Yang, C; Zhang, T; Zhang, Z | 1 |
| Aspeslet, LJ; Foster, RT; Freitag, DG; Huizinga, RB; Larouche, R; Ling, SY; Mayo, PR | 1 |
| Hsiao, P; Unadkat, JD | 1 |
| Achilli, TM; McCalla, S; Meyer, J; Morgan, JR; Tripathi, A | 1 |
| Król, M; Majchrzak, K; Motyl, T; Mucha, J; Pawłowski, KM | 1 |
| Fung, KL; Gottesman, MM; Hall, MD; Pixley, JN; Pluchino, KM; Pouliot, LM; Tepede, AK | 1 |
| Chen, WC; Huang, L; Li, HY; Liu, JS; Wang, J; Yang, WD | 1 |
| Das, T; Foroutan, P; Gatenby, RA; Gillies, RJ; Kam, Y; Martinez, G; Minton, S; Ruiz, E; Tian, H | 1 |
| Fukami, T; Suzuki, T; Tomono, K | 1 |
| Gobec, M; Gurwitz, D; Markovič, T; Mlinarič-Raščan, I | 1 |
| Ding, CH; Li, SL; Long, MH; Mao, Q; Shakya, S; Zhu, H; Zhu, SC | 1 |
| de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M | 1 |
| Aramaki, H; Ishiwata, K; Okamoto, M; Shimizu, I; Toyohara, J; Zaitsu, Y | 1 |
| Chu, K; Jung, KH; Lee, DS; Lee, DY; Lee, JS; Lee, SK; Lee, ST; Lee, YS; Moon, J; Shin, JW; Shin, SA | 1 |
| Bernkop-Schnürch, A; Laffleur, F; Netsomboon, K; Suchaoin, W | 1 |
| Eid, AA; El-Mas, MM; Hammoud, SH; Omar, AG | 1 |
| Hou, J; Hu, JC; Huang, Y; Li, YT; Liu, T; Wang, AM | 1 |
| Doligalska, M; Donskow-Łysoniewska, K; Kozłowska, E; Krawczak, K | 1 |
| Boncela, J; Kryczka, J | 1 |
| Huo, X; Liu, K; Liu, Q; Liu, Z; Ma, X; Meng, Q; Sun, H; Sun, P; Wang, C; Yang, X; Zhang, Y | 1 |
| Khangembam, R; Rath, SS; Singh, H; Singh, NK | 1 |
| Alkhansa, S; Eid, AA; El-Mas, MM; Hammoud, SH; Mahjoub, N; Omar, AG | 1 |
| Breier, A; Elefantova, K; Kubickova, J; Lakatos, B; Sulova, Z | 1 |
| Cho, HS; Jung, CR; Kang, HM; Lim, JH; Noh, KH; Park, D; Susztak, K | 1 |
19 review(s) available for verapamil and cyclosporine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Perioperative fluid and drug therapy during cadaver kidney transplantation.
Topics: Albumins; Body Fluids; Cadaver; Cyclosporine; Fluid Therapy; Graft Survival; Humans; Kidney Transplantation; Survival Rate; Verapamil | 1992 |
Multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; DNA Topoisomerases, Type I; Drug Resistance; Humans; Membrane Glycoproteins; Verapamil | 1992 |
In vivo models of P-glycoprotein-mediated multidrug resistance.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clone Cells; Cloning, Molecular; Cyclosporine; Drug Resistance, Multiple; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Quinidine; Recombinant Fusion Proteins; Reproducibility of Results; Research Design; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured; Verapamil | 1994 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Chemoresistance in the clinic: overview 1994.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dipyridamole; Drug Resistance, Multiple; Glutathione; Humans; Neoplasms; Nifedipine; Verapamil | 1994 |
[Trials of modulating the MDR1 phenotype in malignant hemopathies].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dexamethasone; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid, Acute; Multiple Myeloma; Quinine; Verapamil; Vincristine | 1994 |
Do calcium channel blockers have renal protective effects?
Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil | 1994 |
[Development of drugs to overcome drug resistance--basic approaches].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Drug Resistance, Multiple; Humans; Leukemia P388; Leukemia, Myeloid; Mice; Mice, Nude; Quinolines; Tumor Cells, Cultured; Verapamil | 1995 |
[Resistance to cytostatic agents in patients with refractory multiple myeloma and possible ways to control it].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Drug Resistance; Humans; Membrane Glycoproteins; Multiple Myeloma; Verapamil | 1993 |
[Expression of the MDR1 gene in five human cell lines of medullary thyroid cancer and reversion of the resistance to doxorubicine by ciclosporin A and verapamil].
Topics: Antineoplastic Agents; Carcinoma, Medullary; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Thyroid Neoplasms; Tumor Cells, Cultured; Verapamil | 1996 |
Clinical trials of P-glycoprotein reversal in solid tumours.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Quinolines; Tamoxifen; Verapamil | 1996 |
[MDR (Multiple Drug Resistant) type of resistance to chemotherapy in clinical practice].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Child, Preschool; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Immunosuppressive Agents; Mice; Phenotype; Verapamil | 1996 |
Toxic digoxin-drug interactions: the major role of renal P-glycoprotein.
Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Digoxin; Drug Interactions; Glomerular Filtration Rate; Humans; Itraconazole; Kidney Tubules; Quinidine; Verapamil | 1998 |
Drug-induced gingival enlargements.
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin; Verapamil | 1998 |
[Recent advances in the treatment of acute myelogenous leukemia: a view of the new agents].
Topics: Alkyl and Aryl Transferases; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Cyclosporine; Cytarabine; Daunorubicin; Drug Design; Farnesyltranstransferase; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Neoplasm Recurrence, Local; Nucleosides; Oxides; Prognosis; Radioisotopes; Remission Induction; Tetrahydronaphthalenes; Topoisomerase Inhibitors; Tretinoin; Verapamil | 2003 |
Conformational mobility of immobilized proteins.
Topics: Adenosine Triphosphate; Allosteric Regulation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholinergic Agents; Chromatography, Affinity; Chromatography, Liquid; Cyclosporine; Doxorubicin; Ligands; Membrane Proteins; Pharmaceutical Preparations; Protein Binding; Protein Conformation; Receptors, Nicotinic; Technology, Pharmaceutical; Verapamil; Vinblastine | 2007 |
Cell Migration Related to MDR-Another Impediment to Effective Chemotherapy?
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cancer-Associated Fibroblasts; Cell Movement; Cyclosporine; Disease Progression; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Treatment Failure; Verapamil | 2018 |
15 trial(s) available for verapamil and cyclosporine
| Article | Year |
|---|---|
[The pleiotropic drug resistance phenotype: role of reverting agents "in vitro" and "in vivo"].
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cefoperazone; Child; Cyclosporine; Doxorubicin; Drug Evaluation; Drug Synergism; Humans; Leukemia; Membrane Glycoproteins; Neoplasm Proteins; Neoplastic Stem Cells; Nicardipine; Phenotype; RNA, Messenger; RNA, Neoplasm; Verapamil | 1991 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Chemoresistance in the clinic: overview 1994.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dipyridamole; Drug Resistance, Multiple; Glutathione; Humans; Neoplasms; Nifedipine; Verapamil | 1994 |
[Trials of modulating the MDR1 phenotype in malignant hemopathies].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dexamethasone; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid, Acute; Multiple Myeloma; Quinine; Verapamil; Vincristine | 1994 |
Immunosuppressive effects of different calcium channel blockers in human kidney allografts.
Topics: Calcium; Calcium Channel Blockers; Cyclosporine; Cytokines; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isradipine; Kidney Transplantation; Lymphocytes; Prednisolone; Transplantation, Homologous; Verapamil | 1995 |
A controlled, double-blind, randomized trial of verapamil and cyclosporine in cadaver renal transplant patients.
Topics: Adult; Cadaver; Cyclosporine; Double-Blind Method; Female; Graft Rejection; Graft Survival; Humans; Incidence; Kidney Transplantation; Male; Middle Aged; Time Factors; Verapamil | 1993 |
Orthotopic liver transplantation and renal function; outcome of hepatorenal syndrome and trial of verapamil for renal protection in nonhepatorenal syndrome.
Topics: Creatinine; Cyclosporine; Drug Administration Schedule; Female; Follow-Up Studies; Glomerular Filtration Rate; Hepatorenal Syndrome; Humans; Kidney; Liver Transplantation; Male; Middle Aged; Prospective Studies; Reperfusion; Survival Analysis; Time Factors; Verapamil | 1993 |
Beneficial effects of verapamil in renal transplantation.
Topics: Cyclosporine; Female; Graft Rejection; Histocompatibility Testing; Humans; Kidney Transplantation; Male; Verapamil | 1993 |
Verapamil improves Sandimmune immunosuppression, reducing acute rejection episodes.
Topics: Administration, Oral; Adult; Cyclosporine; Drug Administration Schedule; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Infusions, Intravenous; Kidney Transplantation; Verapamil | 1996 |
A randomized controlled trial of verapamil on cyclosporine nephrotoxicity in heart and lung transplant recipients.
Topics: Adult; Costs and Cost Analysis; Cyclosporine; Female; Glomerular Filtration Rate; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Kidney Diseases; Male; Middle Aged; Verapamil | 1997 |
Interaction between cyclosporine A and verapamil, felodipine, and isradipine.
Topics: Adult; Calcium Channel Blockers; Cyclosporine; Drug Interactions; Felodipine; Female; Humans; Immunosuppressive Agents; Isradipine; Kidney Transplantation; Male; Verapamil | 1999 |
A randomized prospective double-blind placebo-controlled study of gallopamil, calcium antagonist of the verapamil type, in stable cyclosporine-treated renal transplant recipients.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Creatinine; Cyclosporine; Double-Blind Method; Gallopamil; Humans; Immunosuppressive Agents; Kidney Transplantation; Placebos; Prospective Studies; Urea; Uric Acid; Verapamil | 2002 |
Verapamil (VP) improves the outcome after renal transplantation (CRT).
Topics: Calcium Channel Blockers; Creatinine; Cyclosporine; Glomerular Filtration Rate; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Ischemia; Kidney Transplantation; Prospective Studies; Retrospective Studies; Time Factors; Tissue and Organ Harvesting; Treatment Outcome; Verapamil | 1992 |
Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Cyclosporine; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Dyes; Humans; Idarubicin; Inhibitory Concentration 50; K562 Cells; Leukemia, Myeloid, Acute; Male; Rhodamine 123; Time Factors; Treatment Outcome; Verapamil | 2009 |
Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin.
Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Verapamil | 2014 |
378 other study(ies) available for verapamil and cyclosporine
| Article | Year |
|---|---|
New purines and purine analogs as modulators of multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channels; Doxorubicin; Drug Resistance, Multiple; Female; Leukemia P388; Leukemia, Experimental; Mice; Molecular Structure; Neoplasm Transplantation; Piperidines; Purines; Structure-Activity Relationship; Triazines; Tumor Cells, Cultured; Vincristine | 1996 |
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Drug Resistance, Multiple; Humans; Ivermectin; Vinblastine | 1997 |
Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Carbocyanines; Drug Resistance, Multiple; Flow Cytometry; Fluorescent Dyes; Humans; Rhodamine 123; Rhodamines; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1997 |
Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein.
Topics: 3T3 Cells; Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cyclosporine; HIV Protease Inhibitors; Mice; Rhodamine 123; Rhodamines; Saquinavir | 1998 |
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbachol; Eosinophilia; Guinea Pigs; Histamine Release; Hypersensitivity; In Vitro Techniques; Indoleacetic Acids; Interleukin-4; Interleukin-5; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; Peritoneal Cavity; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rhinitis, Allergic, Perennial; Structure-Activity Relationship; Trachea | 1999 |
P-glycoprotein inhibition by glibenclamide and related compounds.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Adhesion; Cell Line; Cell Membrane; Cell Survival; Colchicine; Cystic Fibrosis Transmembrane Conductance Regulator; Glyburide; Humans; Hypoglycemic Agents; Immunochemistry; Opossums; Photoaffinity Labels; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors | 1999 |
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Humans; ortho-Aminobenzoates; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Dibenzocycloheptenes; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Quinolines; Testis | 2000 |
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Membrane; Cell Survival; Cyclosporine; Drug Resistance, Neoplasm; Immunosuppressive Agents; Leukemia P388; Macrolides; Mice; Neoplasm Transplantation; Tumor Cells, Cultured; Verapamil; Vinblastine | 2000 |
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium | 2001 |
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.
Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Crystallography, X-Ray; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Erythroxylaceae; Esters; Female; Humans; Madagascar; Medicine, Traditional; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Roots; Plants, Medicinal; Spectrophotometry, Infrared; Stereoisomerism; Tropanes; Tumor Cells, Cultured | 2001 |
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Division; Cyclosporine; Doxorubicin; Drug Resistance, Neoplasm; Humans; Pregnenediones; Progesterone; Radioligand Assay; Receptors, Progesterone; Structure-Activity Relationship; Tumor Cells, Cultured; Verapamil; Vinblastine | 2002 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection | 2002 |
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine | 2002 |
Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cell Line, Transformed; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Kidney Tubules, Proximal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Topics: Biological Transport; Cells, Cultured; Cyclosporine; Estradiol; Glycocholic Acid; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Multidrug Resistance-Associated Proteins; Osmotic Pressure; Propionates; Quinolines; Recombinant Proteins; Transfection | 2003 |
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Clone Cells; Dogs; Gene Expression Regulation; Humans | 2003 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.
Topics: Alkylation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Proliferation; Drug Resistance, Multiple; Drugs, Chinese Herbal; Flavanones; Humans; Scutellaria baicalensis; Structure-Activity Relationship | 2004 |
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
Topics: Algorithms; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Citrus; Cyclosporine; Food-Drug Interactions; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Plant Extracts; Propionates; Quinolines; Saquinavir; Transfection; Verapamil; Vinblastine | 2004 |
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection | 2007 |
New functional assay of P-glycoprotein activity using Hoechst 33342.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors | 2007 |
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Female; Humans; Isoquinolines; Ligands; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines | 2008 |
Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Line, Tumor; Chalcones; Drug Resistance, Neoplasm; Electrons; Humans; Neoplasm Proteins; Small Molecule Libraries; Structure-Activity Relationship | 2008 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Humans; Ligands; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Quantitative Structure-Activity Relationship | 2008 |
Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzene Derivatives; Biological Transport; Cell Line, Tumor; Cell Membrane Permeability; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Methylamines; Neoplasm Proteins; Pyridines; Structure-Activity Relationship | 2008 |
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line; Cell Proliferation; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Lipids; Molecular Structure; Naphthols; Structure-Activity Relationship; Tetrahydroisoquinolines | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chemistry, Pharmaceutical; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Guinea Pigs; Humans; Ileum; Models, Chemical; Rhodamine 123; Tamoxifen; Verapamil | 2008 |
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 2008 |
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.
Topics: 4-Aminobenzoic Acid; Animals; Cell Line; Cell Line, Tumor; Dogs; Drug Resistance, Multiple; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; para-Aminobenzoates; Thiazines | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Models, Molecular | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Paclitaxel; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Vincristine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.
Topics: Aflatoxin B1; Aflatoxins; Antineoplastic Agents; Aspergillus; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; DNA Damage; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Molecular Structure | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
Topics: Adenosine Triphosphatases; Amines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzylamines; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Polyethylene Glycols; Solubility; Structure-Activity Relationship | 2012 |
Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Dipeptides; Doxorubicin; Drug Resistance, Neoplasm; Humans; K562 Cells; Solid-Phase Synthesis Techniques; Structure-Activity Relationship; Tetrahydroisoquinolines; Verapamil | 2012 |
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Topics: Cell Line; Drug Discovery; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters | 2012 |
Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Esters; Humans; Paclitaxel; Structure-Activity Relationship; Vincristine | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Space; Models, Molecular; Molecular Conformation; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Safety; Structure-Activity Relationship | 2013 |
Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.
Topics: Administration, Oral; Alzheimer Disease; Animals; Biological Availability; Brain; Cell Line; Humans; Mice; Microtubules; Molecular Structure; Pyrimidines; Tauopathies | 2014 |
Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; Models, Molecular; Molecular Conformation; Progesterone; Tumor Cells, Cultured | 2015 |
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Catechin; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonols; Humans; Methylation; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |
Extending the structure-activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors.
Topics: Aquatic Organisms; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Heterocyclic Compounds, 3-Ring; Humans; Structure-Activity Relationship | 2017 |
Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Humans; K562 Cells; Molecular Structure; Rhodamine 123; Structure-Activity Relationship; Vinblastine; Vinca; Vinorelbine | 2016 |
Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Female; Furans; Humans; MCF-7 Cells; Molecular Docking Simulation; Structure-Activity Relationship; Tetrahydroisoquinolines | 2018 |
Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".
Topics: Alkynes; Animals; Antineoplastic Agents; Azides; Cell Line, Tumor; Click Chemistry; Dimerization; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Female; Flavonoids; Humans; Intracellular Space; Mice; Molecular Docking Simulation; Multidrug Resistance-Associated Proteins; Protein Conformation | 2018 |
Analogues of the Lignan Pinoresinol as Novel Lead Compounds for P-glycoprotein (P-gp) Inhibitors.
Topics: | 2018 |
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Furans; Humans; Molecular Docking Simulation; Paclitaxel; Structure-Activity Relationship; Tetrahydroisoquinolines | 2021 |
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catechin; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Methylation; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2021 |
[Protective effect of verapamil and dopamine against cyclosporine-induced vasoconstriction in isolated glomeruli in rats].
Topics: Animals; Cyclosporine; Depression, Chemical; Dopamine; In Vitro Techniques; Kidney; Kidney Glomerulus; Male; Rats; Rats, Sprague-Dawley; Vasoconstriction; Verapamil | 1992 |
The restoration of ATP synthesis may explain the protective effect of calcium antagonists against cyclosporine A nephrotoxicity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Cyclosporine; Kidney; Kidney Diseases; Mitochondria, Liver; Nifedipine; Oxygen Consumption; Rats; Verapamil | 1992 |
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture.
Topics: Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Doxorubicin; Drug Resistance; Gene Expression; Liver; Male; Membrane Glycoproteins; Nifedipine; Quinidine; Rats; Rats, Inbred Strains; RNA, Messenger; Verapamil; Vincristine | 1992 |
In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myelogenous leukemia (AML).
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cefoperazone; Cyclosporine; Daunorubicin; Humans; Leukemia, Myeloid, Acute; Membrane Glycoproteins; Middle Aged; Mitoxantrone; Stem Cells; Tumor Cells, Cultured; Verapamil | 1992 |
The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; Kinetics; Membrane Glycoproteins; Quinidine; Verapamil; Vinblastine | 1992 |
Evaluation of a method for detection of cells with reduced drug retention in solid tumours.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Cell Survival; Chromatography, High Pressure Liquid; Culture Media; Cyclosporine; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Friend murine leukemia virus; Humans; Hydrogen-Ion Concentration; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Mice; Neoplasm Proteins; Neoplasms; Nephelometry and Turbidimetry; Reference Standards; Reproducibility of Results; Treatment Outcome; Tumor Cells, Cultured; Verapamil | 1992 |
Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Capillaries; Cells, Cultured; Cyclosporine; Drug Resistance; Endothelium, Vascular; Humans; Membrane Glycoproteins; Mice; Rhodamine 123; Rhodamines; Swine; Verapamil | 1992 |
P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Carrier Proteins; Cyclosporine; Drug Resistance; Gene Expression; Humans; Immunophenotyping; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Membrane Glycoproteins; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil | 1992 |
[Cyclosporine-verapamil interaction].
Topics: Adult; Behcet Syndrome; Cyclosporine; Drug Interactions; Female; Humans; Verapamil | 1992 |
The effects of cyclosporin A on the lysis of ovarian cancer cells by cisplatin or adriamycin.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Death; Cisplatin; Cycloheximide; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance; Emetine; Female; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1992 |
Correlation of cyclosporine-induced nephropathy with renal microsomal cytochrome P-450: the preventive effect of verapamil.
Topics: Animals; Cyclosporine; Cytochrome P-450 Enzyme System; Kidney; Kidney Diseases; Male; Microsomes; Rats; Rats, Inbred Strains; Verapamil | 1992 |
IL-2 responsiveness of lectin-induced lymphoblasts: soluble IL-2 receptor release and differential in vitro effects of immunosuppressants.
Topics: CD4 Antigens; CD8 Antigens; Cyclosporine; Egtazic Acid; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Prednisolone; Receptors, Interleukin-2; Recombinant Proteins; T-Lymphocytes; Verapamil | 1992 |
Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro.
Topics: Cyclosporine; Daunorubicin; Drug Resistance; Drug Synergism; Humans; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Effect of ciclosporin on cardiac output and regional blood flow in rats: ciclosporin-induced nephropathy and its prevention with calcium channel blocker.
Topics: Animals; Cardiac Output; Cyclosporine; Hemodynamics; Ischemia; Kidney; Kidney Diseases; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Verapamil | 1992 |
FK 506 is a direct glomeruloconstrictor, as determined by electrical resistance pulse sizing (ERPS).
Topics: Animals; Cyclosporine; Electrophysiology; In Vitro Techniques; Kidney Glomerulus; Rats; Tacrolimus; Verapamil | 1991 |
FK-506 (fujimycin) reverses the multidrug resistance of tumor cells in vitro.
Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; Cyclosporine; Doxorubicin; Drug Resistance; Leukemia P388; Tacrolimus; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.
Topics: Animals; Antineoplastic Agents; Blotting, Southern; Bone Marrow; Bone Marrow Transplantation; Cyclosporine; DNA; Drug Resistance; Gene Expression; Humans; Leukocyte Count; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; Spleen; Time Factors; Verapamil | 1992 |
[Effects of verapamil on cyclosporine. A (CsA)-induced nephropathy in ischemic kidney model in rats: changes in systemic hemodynamics and hepatic and renal microsomal cytochrome P-450].
Topics: Animals; Cyclosporine; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Hemodynamics; Ischemia; Kidney; Kidney Diseases; Microsomes; Microsomes, Liver; Nephrectomy; Rats; Rats, Inbred Strains; Renal Circulation; Verapamil | 1991 |
Verapamil improves the outcome after cadaver renal transplantation.
Topics: Adult; Blood Pressure; Cadaver; Cyclosporine; Diuresis; Female; Glomerular Filtration Rate; Graft Survival; Humans; Kidney Transplantation; Male; Middle Aged; Renal Circulation; Verapamil | 1991 |
Experimental studies on the nephrotoxicity of amphotericin B in rats.
Topics: Amphotericin B; Animals; Creatinine; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Female; Kidney Tubules; Rats; Rats, Inbred Strains; Tobramycin; Urination; Verapamil | 1991 |
Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Kidney Diseases; Kidney Tubules; Leucine; Microscopy, Fluorescence; Nifedipine; Rabbits; Time Factors; Verapamil | 1991 |
[Effect of verapamil on cyclosporine-induced vasoconstriction in human or murine isolated glomerules].
Topics: Animals; Cyclosporine; Depression, Chemical; Humans; In Vitro Techniques; Kidney; Kidney Diseases; Male; Rats; Stimulation, Chemical; Vasoconstriction; Verapamil | 1991 |
Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes.
Topics: Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carrier Proteins; Cyclosporine; Cyclosporins; Drug Resistance; Female; Humans; KB Cells; Killer Cells, Natural; Leukemia, Myeloid; Lymphocytes; Membrane Glycoproteins; Monocytes; Neoplasm Proteins; Ovarian Neoplasms; Protein Binding; Tacrolimus; Tumor Cells, Cultured; Verapamil | 1994 |
Modulation of multidrug resistance in de novo adult acute myeloid leukemia: variable efficacy of reverting agents in vitro. Eastern Cooperative Oncology Group.
Topics: Acute Disease; Antigens, CD; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dexamethasone; Drug Resistance, Multiple; Humans; Leukemia, Myeloid; Rhodamines; Tumor Cells, Cultured; Verapamil | 1995 |
Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucleus; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Neoplasm Proteins; Piperidines; Subcellular Fractions; Triazines; Tumor Cells, Cultured; Verapamil | 1995 |
[Treatment of metastatic osteosarcoma with verapamil, cyclosporine and chemotherapy. A case report].
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclosporine; Femur; Humans; Lung; Lung Neoplasms; Male; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Verapamil | 1995 |
Expression and function of P-glycoprotein in a mouse kidney cell line.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cell Polarity; Cricetinae; Cyclosporine; Epithelium; Homeostasis; Immunologic Techniques; Kidney; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Rhodamine 123; Rhodamines; RNA, Messenger; Verapamil | 1995 |
Daunomycin secretion by killfish renal proximal tubules.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buffers; Cyclosporine; Daunorubicin; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Kidney Tubules, Proximal; Killifishes; Microscopy, Fluorescence; Television; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1995 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil | 1995 |
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Doxorubicin; Drug Resistance; Membrane Glycoproteins; Tacrolimus; Tumor Cells, Cultured; Verapamil | 1993 |
Natural killer cell cytotoxicity and the multidrug resistance gene.
Topics: CD8 Antigens; Chloroquine; Cyclosporine; Cytotoxicity, Immunologic; DNA; Drug Resistance; Humans; Killer Cells, Natural; Membrane Glycoproteins; Perforin; Polyethylene Glycols; Polymerase Chain Reaction; Pore Forming Cytotoxic Proteins; RNA; Stearic Acids; T-Lymphocytes, Cytotoxic; Verapamil | 1993 |
Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Canaliculi; Cyclosporine; Daunorubicin; Drug Resistance; Fluoresceins; Fluorescent Dyes; Fura-2; Liver; Membrane Glycoproteins; Microscopy, Fluorescence; Progesterone; Rats; Signal Processing, Computer-Assisted; Tacrolimus; Verapamil; Vinblastine | 1993 |
Differential modulation of P-glycoprotein transport by protein kinase inhibition.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carrier Proteins; Cyclosporine; Dactinomycin; Dihydropyridines; Drug Resistance; Humans; Isoenzymes; Membrane Glycoproteins; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1993 |
Image analyser as a tool for the study of in vitro glomerular vasoreactivity.
Topics: Angiotensin II; Animals; Cell Size; Cells, Cultured; Cyclosporine; Glomerular Mesangium; Image Processing, Computer-Assisted; Kidney Glomerulus; Microscopy, Video; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1994 |
Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Tumor Cells, Cultured; Verapamil; Vincristine | 1995 |
Partial circumvention of multi-drug resistance by annamycin is associated with comparable inhibition of DNA synthesis in the nuclear matrix of sensitive and resistant cells.
Topics: Antibiotics, Antineoplastic; Biological Transport; Cell Membrane; Cyclosporine; DNA Replication; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Humans; KB Cells; Microscopy, Fluorescence; Monensin; Nuclear Matrix; Subcellular Fractions; Verapamil | 1995 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Humans; Leukemia; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
Cyclosporin A, verapamil and S9788 reverse doxorubicin resistance in a human medullary thyroid carcinoma cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Medullary; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Glutathione; Glutathione Transferase; Humans; Neoplasm Proteins; Piperidines; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thyroid Neoplasms; Triazines; Verapamil | 1995 |
Prevention of acute cyclosporin nephrotoxicity by verapamil and atrial natriuretic factor in the rat.
Topics: Animals; Atrial Natriuretic Factor; Cyclosporine; Glomerular Filtration Rate; Kidney; Male; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation; Vascular Resistance; Verapamil | 1994 |
Validation of a single point flow cytometric assay for determining P-glycoprotein activity in multidrug resistant cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Fluorometry; Humans; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil | 1994 |
Heat-shock-stimulated transepithelial daunomycin secretion by flounder renal proximal tubule primary cultures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Cycloheximide; Cyclosporine; Daunorubicin; Epithelial Cells; Epithelium; Flounder; Hot Temperature; Immunohistochemistry; Kidney Tubules, Proximal; Kinetics; Microvilli; p-Aminohippuric Acid; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil; Vinblastine | 1995 |
P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Fluorescent Dyes; Kidney Tubules, Proximal; Killifishes; Kinetics; Microscopy, Fluorescence; p-Aminohippuric Acid; Potassium Cyanide; Quinine; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Verapamil; Vinblastine | 1995 |
Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Graft Survival; Humans; Immunosuppression Therapy; Infusions, Intravenous; Kidney; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nova Scotia; Retrospective Studies; Time Factors; Verapamil | 1994 |
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Death; Cell Survival; Colchicine; Cyclosporine; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Membrane Glycoproteins; Mice; Phenotype; Point Mutation; Quinidine; Transfection; Verapamil | 1995 |
Constitutive expression of P-glycoprotein as a determinant of loading with fluorescent calcium probes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Cytosol; Female; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Indoles; Rhodamine 123; Rhodamines; Verapamil | 1994 |
Protective effect of verapamil in cyclosporin-incubated human and murine isolated glomeruli.
Topics: Adult; Animals; Cyclosporine; Glomerular Filtration Rate; Humans; In Vitro Techniques; Kidney Glomerulus; Rats; Rats, Sprague-Dawley; Vasoconstriction; Verapamil | 1994 |
The efflux of anthracyclines in multidrug-resistant cell lines.
Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Mice; Phenotype; Tumor Cells, Cultured; Verapamil | 1993 |
Evaluation of flow cytometry for multidrug resistance detection in low resistance K562 cells using daunorubicin and monoclonal antibodies.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Drug Resistance; Flow Cytometry; Gene Expression; Humans; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine | 1993 |
Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Peptides, Cyclic; Tumor Cells, Cultured; Verapamil | 1993 |
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Daunorubicin; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Microtubules; Paclitaxel; Tumor Cells, Cultured; Verapamil | 1994 |
Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cyclosporine; Cyclosporins; Depression, Chemical; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Hydrogen-Ion Concentration; Ileal Neoplasms; Ileocecal Valve; Membrane Glycoproteins; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
A non-P-glycoprotein-mediated mechanism of vincristine transport which is affected by resistance modifiers and present in chemosensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cell Survival; Cells, Cultured; Cyclosporine; Daunorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Gene Expression; Heart; Humans; Leukemia, Experimental; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Membrane Glycoproteins; Myocardium; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
In vitro evaluation of chemosensitizers for clinical reversal of P-glycoprotein-associated Taxol resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Drug Resistance; Humans; Membrane Glycoproteins; Multiple Myeloma; Paclitaxel; Quinine; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1993 |
Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Doxorubicin; Drug Resistance; Female; Humans; Leukemia; Male; Membrane Glycoproteins; Middle Aged; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
Development of vincristine resistance and increased sensitivity to cyclosporin A and verapamil in the human U-937 lymphoma cell line without overexpression of the 170-kDa P-glycoprotein.
Topics: Antigens, Surface; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Differentiation; Cell Division; Cyclosporine; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Lymphoma, Large B-Cell, Diffuse; Membrane Glycoproteins; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Carrier Proteins; Cells, Cultured; Cyclosporine; Endothelium, Vascular; Immunoblotting; Membrane Glycoproteins; Mice; Verapamil | 1994 |
Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport.
Topics: Acridine Orange; Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Bile Canaliculi; Blotting, Western; Carrier Proteins; Cell Membrane; Cyclosporine; Dihydropyridines; In Vitro Techniques; Liver; Male; Membrane Glycoproteins; Models, Biological; Perfusion; Precipitin Tests; Rats; Rats, Inbred Strains; Verapamil | 1994 |
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Extracellular Space; Leukemia P388; Membrane Glycoproteins; Mice; Molecular Sequence Data; Peptides, Cyclic; Verapamil | 1994 |
The function of heat-shock proteins in stress tolerance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Carrier Proteins; Cell Division; Cyclosporine; Dexamethasone; Drug Resistance; Heat-Shock Proteins; Hot Temperature; Liver Neoplasms, Experimental; Membrane Glycoproteins; Rats; Tumor Cells, Cultured; Verapamil | 1994 |
Flow cytometric monitoring of anthracycline accumulation after anti-neoplastic ether phospholipid treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Interactions; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Leukemia, Myeloid; Leukemia, T-Cell; Phospholipid Ethers; Tumor Cells, Cultured; Verapamil | 1994 |
Use of two in vitro glomerular models to study the renal vasoreactivity of cyclosporine.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Felodipine; Glomerular Mesangium; In Vitro Techniques; Kidney Cortex; Kidney Glomerulus; Kinetics; Nifedipine; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Verapamil | 1994 |
Deleterious effect of cyclosporines on the ischemic kidney in the rat and protection by the calcium antagonist verapamil.
Topics: Animals; Cyclosporine; Cyclosporins; Immunosuppressive Agents; Ischemia; Kidney; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Circulation; Verapamil | 1994 |
Efficacy of verapamil in prevention of cyclosporine nephrotoxicity in the rat.
Topics: Analysis of Variance; Animals; Blood Urea Nitrogen; Creatinine; Cyclosporine; Kidney; Male; Rats; Rats, Sprague-Dawley; Systole; Verapamil | 1994 |
The interaction of the calcium channel blockers verapamil and nifedipine with cyclosporin A in pediatric renal transplant patients.
Topics: Adolescent; Child; Child, Preschool; Cyclosporine; Drug Interactions; Graft Rejection; Half-Life; Humans; Hypertension; Kidney Transplantation; Nifedipine; Verapamil | 1994 |
Deleterious effect of cyclosporins on the ischemic kidney in the rat and the protection by the calcium antagonist verapamil.
Topics: Animals; Creatinine; Cyclosporine; Cyclosporins; Ischemia; Kidney; Kidney Diseases; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Circulation; Verapamil | 1994 |
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Genetic Vectors; HeLa Cells; Humans; Molecular Weight; RNA, Messenger; Transfection; Verapamil; Vincristine | 1994 |
Modulation of anthracycline accumulation and metabolism in rat hepatocytes in culture by three revertants of multidrug resistance.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cells, Cultured; Cyclosporine; Drug Resistance, Multiple; Liver; Male; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Up-Regulation; Verapamil | 1994 |
Increased intracellular concentrations of doxorubicin in resistant lymphoma cells in vivo by concomitant therapy with verapamil and cyclosporin A.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Male; Verapamil | 1994 |
Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cell Survival; Cyclosporine; Drug Resistance; Humans; Membrane Glycoproteins; Tetracycline; Tetracycline Resistance; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Colonic Neoplasms; Cyclosporine; Drug Resistance; Drug Synergism; Male; Membrane Glycoproteins; Neoplasm Proteins; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Verapamil | 1993 |
Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Carrier Proteins; Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance; Female; Humans; Leukemia, Myeloid, Acute; Male; Membrane Glycoproteins; Middle Aged; Tumor Cells, Cultured; Verapamil | 1993 |
Derivation and characterisation of a mouse tumour cell line with acquired resistance to cyclosporin A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinosarcoma; Carrier Proteins; Cyclosporine; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Resistance; Mammary Neoplasms, Experimental; Membrane Glycoproteins; Mice; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Doxorubicin; Drug Resistance; Humans; Male; Membrane Glycoproteins; Phenotype; Prostatic Neoplasms; Rhodamine 123; Rhodamines; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carrier Proteins; Cattle; Cells, Cultured; Chlorpromazine; Cyclosporine; Membrane Glycoproteins; Progesterone; Tritium; Verapamil; Vincristine | 1993 |
Cyclosporine levels predict the likelihood of rejection after simultaneous pancreas/kidney transplantation.
Topics: Adult; Biopsy, Needle; Cyclosporine; Follow-Up Studies; Graft Rejection; Humans; Immunosuppression Therapy; Kidney Transplantation; Middle Aged; Pancreas Transplantation; Prognosis; Time Factors; Verapamil | 1994 |
Verapamil improves the function of mouse islet transplants.
Topics: Animals; Cell Separation; Cells, Cultured; Collagenases; Cyclosporine; Female; Glucose; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Male; Mice; Mice, Inbred Strains; Mice, Obese; Pancreas; Polyethylene Glycols; Time Factors; Verapamil | 1994 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; ErbB Receptors; Exotoxins; Female; Humans; Lung Neoplasms; Recombinant Fusion Proteins; Recombinant Proteins; Tamoxifen; Transforming Growth Factor alpha; Tumor Cells, Cultured; Verapamil | 1994 |
Chemosensitisation effect of verapamil and cyclosporin A in vitro is reduced under acidic pH conditions.
Topics: Colonic Neoplasms; Cyclosporine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Tumor Cells, Cultured; Verapamil | 1993 |
IL-4 receptor expression by SAC-activated B-lymphocytes: its role in B-cell proliferation and the effect of cyclosporine (CsA), prednisolone and verapamil.
Topics: B-Lymphocytes; Cell Division; Cyclosporine; Humans; In Vitro Techniques; Interleukin-4; Lymphocyte Activation; Prednisolone; Receptors, Interleukin-4; Receptors, Mitogen; Staphylococcus aureus; Verapamil | 1993 |
The protective effect of verapamil on mouse islets transplanted under the kidney capsule.
Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Kidney Cortex; Male; Mice; Mice, Inbred Strains; Multivariate Analysis; Perfusion; Transplantation, Heterotopic; Transplantation, Isogeneic; Verapamil | 1993 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Effects of cyclosporin A and verapamil on mouse pancreatic islets.
Topics: Animals; Cyclosporine; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Verapamil | 1993 |
Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclosporine; Drug Resistance; Humans; Liver Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines.
Topics: Cell Survival; Cyclosporine; Doxorubicin; Eye Neoplasms; Humans; Retinoblastoma; Tumor Cells, Cultured; Verapamil | 1993 |
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
Topics: Carcinoma, Non-Small-Cell Lung; Cyclosporine; Cyclosporins; Daunorubicin; Humans; Lung Neoplasms; Membrane Proteins; Molecular Weight; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vincristine | 1993 |
Chronic cyclosporin A (CsA) nephrotoxicity in the rat: the effect of calcium blockade with verapamil.
Topics: Animals; Blood Glucose; Body Weight; Cyclosporine; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Cyclosporine and oxidized lipoproteins affect vascular reactivity. Influence of the endothelium.
Topics: Acetylcholine; Animals; Cyclosporine; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Indomethacin; Lipoproteins, LDL; Male; Norepinephrine; Oxidation-Reduction; Rabbits; Renal Artery; Saralasin; Vasoconstriction; Verapamil | 1993 |
Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Transport, Active; Blotting, Northern; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genistein; HL-60 Cells; Humans; Isoflavones; Leukemia; RNA, Messenger; RNA, Neoplasm; Temperature; Time Factors; Tumor Cells, Cultured; Verapamil | 1996 |
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD8-Positive T-Lymphocytes; Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Rhodamine 123; Rhodamines; Verapamil | 1995 |
Differences between accumulation of 99mTc-MIBI and 201Tl-thallous chloride in tumour cells: role of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cyclosporine; Down-Regulation; Drug Resistance, Neoplasm; Radionuclide Imaging; Technetium Tc 99m Sestamibi; Thallium; Thallium Radioisotopes; Tumor Cells, Cultured; Verapamil | 1995 |
The effect of calcium channel blockers on cyclosporine A (Cs A) induced nephrotoxicity in rats.
Topics: Animals; Calcium Channel Blockers; Creatinine; Cyclosporine; Glomerular Filtration Rate; Kidney; Male; Nifedipine; Rats; Rats, Wistar; Verapamil | 1995 |
[Effect of S9788, cyclosporin A and verapamil on intracellular accumulation of doxorubicin, daunorubicin and daunorubicinol in primary rat hepatocyte culture].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Liver; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Verapamil | 1996 |
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Endocytosis; Humans; Ileal Neoplasms; Ileocecal Valve; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; Phytohemagglutinins; Recombinant Proteins; T-Lymphocytes; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1996 |
Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1996 |
Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blotting, Western; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Dexamethasone; Diuretics, Osmotic; Glucocorticoids; Humans; Immunosuppressive Agents; Mannitol; Permeability; Time Factors; Verapamil | 1996 |
[Enhancement of cytotoxic effect of anticancer agents of renal cell carcinoma].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Renal Cell; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Humans; Immunosuppressive Agents; Kidney Neoplasms; Tumor Cells, Cultured; Verapamil; Vinblastine | 1996 |
Decreased uptake of cyclosporin A by P-glycoprotein (Pgp) expressing CEM leukemic cells and restoration of normal retention by Pgp blockers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Flow Cytometry; Humans; Immunosuppressive Agents; Leukemia, Monocytic, Acute; Leukemia, T-Cell; Mice; Peptides, Cyclic; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Activity of N-benzyl-adriamycin-14-valerate (AD198), a new anthracycline derivate, in multidrug resistant human ovarian and breast carcinoma cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1995 |
Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A.
Topics: Adult; Antigenic Variation; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Diltiazem; Disease Susceptibility; Drug Combinations; Female; Gingival Overgrowth; HLA Antigens; HLA-DR1 Antigen; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Nifedipine; Pharmacogenetics; Statistics, Nonparametric; Verapamil | 1996 |
alpha-(3,4-dimethyoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha- [(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile (CL 329,753): a novel chemosensitizing agent for P-glycoprotein-mediated resistance with improved biological properties compared with ver
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Humans; Isoquinolines; Transfection; Tumor Cells, Cultured; Verapamil | 1996 |
Dose-dependent stimulation/inhibition effects of cyclosporin A on lysosomal cathepsin activities in cultured proximal tubule cells.
Topics: Calcimycin; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Endopeptidases; Enzyme Inhibitors; Kidney Tubules, Proximal; Lipid Peroxides; Lysosomes; Microscopy, Phase-Contrast; Proteins; Superoxide Dismutase; Verapamil | 1995 |
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Screening Assays, Antitumor; Humans; Kidney; Leukemia P388; Mice; Plasma; Quinidine; Verapamil; Vinblastine | 1996 |
Arsenite efflux is inhibited by verapamil, cyclosporin A, and GSH-depleting agents in arsenite-resistant Chinese hamster ovary cells.
Topics: Animals; Arsenites; Calcium Channel Blockers; Carcinogens; Cells, Cultured; CHO Cells; Cricetinae; Cyclosporine; Dinitrofluorobenzene; Drug Resistance, Multiple; Glutathione; Glutathione Transferase; Maleates; Potassium Cyanide; Teratogens; Verapamil | 1996 |
The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Drug Combinations; Female; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Periodontal Index; Statistics, Nonparametric; Verapamil | 1996 |
Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells.
Topics: Ceramides; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glycosphingolipids; Glycosylation; Humans; Meperidine; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1997 |
Functional modulation of ATPase of P-glycoprotein by C219, a monoclonal antibody against P-glycoprotein.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Adenosine Triphosphate; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Breast Neoplasms; Cell Line; Cell Membrane; Cyclosporine; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Kinetics; Tumor Cells, Cultured; Verapamil | 1997 |
Relationship between the inhibition of azidopine binding to P-glycoprotein by MDR modulators and their efficiency in restoring doxorubicin intracellular accumulation.
Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cyclosporine; Cyclosporins; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Mice; Nicardipine; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1996 |
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine | 1997 |
Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Separation; Clone Cells; Cyclosporine; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Humans; Isoenzymes; Lung Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1997 |
Uptake and efflux of polycyclic aromatic hydrocarbons by Tetrahymena pyriformis: evidence for a resistance mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Division; Cyclosporine; Flow Cytometry; Gas Chromatography-Mass Spectrometry; Methylcholanthrene; Polycyclic Aromatic Hydrocarbons; Tetrahymena pyriformis; Verapamil | 1997 |
Regulation of chitin synthase activity in the dimorphic fungus Benjaminiella poitrasii by external osmotic pressure.
Topics: Calcium Channel Blockers; Cantharidin; Chitin Synthase; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Genistein; Hydrogen-Ion Concentration; Isoflavones; Mucorales; Osmotic Pressure; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Signal Transduction; Sorbitol; Verapamil | 1997 |
The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine | 1997 |
Drug-stimulated ATPase activity of human P-glycoprotein requires movement between transmembrane segments 6 and 12.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Humans; Membrane Glycoproteins; Movement; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Transfection; Verapamil; Vinblastine | 1997 |
Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chlorocebus aethiops; Coccidiostats; Cyclosporine; Cyclosporins; Enzyme Inhibitors; Female; Immunosuppressive Agents; Mice; Peptidylprolyl Isomerase; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Toxoplasma; Verapamil; Vero Cells | 1997 |
An homogeneous assay for measuring the uptake and efflux of radiolabelled drugs in adherent cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Carcinoma, Squamous Cell; Cell Adhesion; Cell Division; Cell Survival; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Humans; Thymidine; Verapamil | 1997 |
Comparative effect of verapamil, cyclosporin A and SDZ PSC 833 on rhodamine 123 transport and cell cycle in vinblastine-resistant Chinese hamster ovary cells overexpressing P-glycoprotein.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Cell Line; CHO Cells; Cricetinae; Cyclosporine; Cyclosporins; DNA; Drug Resistance, Neoplasm; Flow Cytometry; Immunosuppressive Agents; Rhodamine 123; Rhodamines; Verapamil; Vinblastine | 1997 |
Changes in anion permeability following hypotonic challenge in rat brain endothelial cells: different responses in primary cultures and in immortalised RBE4 cells.
Topics: Animals; Anions; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Transformed; Cell Membrane Permeability; Cerebral Cortex; Cyclosporine; Endothelium, Vascular; Hypotonic Solutions; Iodides; Kinetics; Microcirculation; Rats; Verapamil; Vincristine | 1997 |
Comparison between anthracyclines and rhodamine-123 accumulation in chronic lymphoid leukemia: effect of cyclosporin A and verapamil.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1998 |
MDR1 in taste buds of rat vallate papilla: functional, immunohistochemical, and biochemical evidence.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Connective Tissue Cells; Cyclosporine; Epithelial Cells; Female; Fluoresceins; Fluorescent Dyes; Immunoglobulin G; In Vitro Techniques; Kinetics; Male; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Tamoxifen; Taste Buds; Tongue; Verapamil | 1998 |
Evidence for the involvement of P-glycoprotein on the extrusion of taken up L-DOPA in cyclosporine A treated LLC-PK1 cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benserazide; Body Water; Calcium Channel Blockers; Cell Survival; Cyclosporine; Decarboxylation; Dopamine; Dopamine Agents; Levodopa; LLC-PK1 Cells; Swine; Verapamil | 1998 |
The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Colchicine; Cyclosporine; Dipyridamole; Lipids; Rats; Solubility; Verapamil; Zidovudine | 1998 |
P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with chemosensitizers in HCT-8 carcinoma cells in vitro.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Ileal Neoplasms; Ileocecal Valve; Kinetics; Phosphorylation; Rhodamine 123; Rhodamines; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Survival; Cisplatin; Cyclophosphamide; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Humans; Kinetics; Lung Neoplasms; Methotrexate; Neuroblastoma; Rhabdomyosarcoma; Time Factors; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cyclosporine; Enzyme Inhibitors; Ethylmaleimide; Fluoresceins; Fluorouracil; Humans; Protein Binding; Recombinant Proteins; Verapamil | 1998 |
Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cyclosporine; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Intestinal Absorption; Ritonavir; Saquinavir; Verapamil; Vinblastine | 1998 |
The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Idarubicin; Leukemia; Tumor Cells, Cultured; Verapamil | 1998 |
Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Fluorescent Dyes; Injections, Subcutaneous; Iodine Radioisotopes; Kidney; Liver; Male; Microvilli; Photoaffinity Labels; Prazosin; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; Verapamil; Vinblastine | 1998 |
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.
Topics: Acridines; Cell Death; Clofazimine; Cyclosporine; Drug Resistance, Multiple; Humans; Isoquinolines; Lung Neoplasms; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil; Vinblastine; Vitamin E | 1998 |
Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells.
Topics: Absorption; Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blotting, Western; Cell Membrane Permeability; Cells, Cultured; Conjunctiva; Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Ion Pumps; Male; Pharmaceutical Preparations; Progesterone; Rabbits; Verapamil | 1998 |
The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Survival; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genistein; Humans; In Vitro Techniques; Multidrug Resistance-Associated Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil | 1998 |
Cyclosporin A has low potency as a calcineurin inhibitor in cells expressing high levels of P-glycoprotein.
Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Calcium Channel Blockers; Cyclosporine; Humans; Immunosuppressive Agents; KB Cells; Molecular Sequence Data; Verapamil; Vinblastine | 1998 |
Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Dipyridamole; Drug Interactions; Drug Resistance, Multiple; Humans; Leukemia; Lymphoma; Multidrug Resistance-Associated Proteins; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Estimation of drug resistance by flow cytometry.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Genistein; Leukemia L5178; Mice; Probenecid; Recombinant Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Verapamil | 1998 |
Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants.
Topics: Animals; Corticosterone; Cortodoxone; Cyclosporine; Desoxycorticosterone; Dexamethasone; Genes, Reporter; Glucocorticoids; Hydrocortisone; Immunosuppressive Agents; L Cells; Luciferases; Mice; Polyenes; Quinidine; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Sirolimus; Tacrolimus; Transcription, Genetic; Transfection; Triamcinolone Acetonide; Verapamil | 1998 |
Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Cattle; Coculture Techniques; Cyclosporine; Doxorubicin; Endothelium, Vascular; Immunosuppressive Agents; Piperidines; Predictive Value of Tests; Rats; Triazines; Verapamil; Vincristine | 1998 |
Verapamil prevents cyclosporine-induced hypertension by modulating endothelin A receptor expression in rat kidney membranes.
Topics: Animals; Blood Pressure; Cell Membrane; Cyclosporine; Endothelin-1; Gene Expression Regulation; Hypertension; Iodine Radioisotopes; Kidney; Male; Radioligand Assay; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Verapamil | 1998 |
Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Line; Cyclosporine; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Humans; Immunohistochemistry; Kidney Tubules; Kinetics; Rats; Tacrolimus; Verapamil | 1998 |
Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Quinolines; Tumor Cells, Cultured; Verapamil | 1998 |
The possible role of endothelin(s) in cyclosporine A preparations--induced contraction of guinea pig isolated gallbladder strips.
Topics: Animals; Bosentan; Cyclosporine; Endothelins; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pharmaceutical Vehicles; Sphincter of Oddi; Sulfonamides; Verapamil | 1998 |
Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Breast Neoplasms; Cyclosporine; Female; Humans; Rhodamine 123; Sensitivity and Specificity; Verapamil | 1996 |
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Topics: Adenocarcinoma; Cell Survival; Colchicine; Cyclosporine; Cytochalasin B; Cytochalasin D; Cytoskeleton; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Neoplasm Proteins; Paclitaxel; Tubulin; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Detection of a P-glycoprotein related pump in Chironomus larvae and its inhibition by verapamil and cyclosporin A.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Chironomidae; Cyclosporine; Immunohistochemistry; Insecticide Resistance; Larva; Rhodamine 123; Verapamil; Xenobiotics | 1998 |
Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
Topics: Administration, Oral; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Isradipine; Medical Records; Nifedipine; Radioimmunoassay; Retrospective Studies; Verapamil | 1999 |
Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier.
Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Humans; KB Cells; Kinetics; L Cells; Mice; Propanolamines; Tritium; Verapamil; Vinblastine | 1999 |
Influence of cell concentration in limiting the therapeutic benefit of P-glycoprotein reversal agents.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Calcium Channel Blockers; Cell Count; Cell Survival; CHO Cells; Colony-Forming Units Assay; Cricetinae; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Humans; Immunosuppressive Agents; Technetium Tc 99m Sestamibi; Tumor Cells, Cultured; Verapamil | 1999 |
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Chemistry; Calcium Channel Blockers; Carcinoma, Small Cell; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Rats; Rats, Nude; Recombinant Fusion Proteins; Tissue Distribution; Tumor Cells, Cultured; Verapamil | 1999 |
Drug concentration-dependent expression of multidrug resistance-associated protein and P-glycoprotein in the doxorubicin-resistant acute myelogenous leukemia sublines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Gene Expression; Humans; Leukemia, Myeloid, Acute; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil | 1999 |
Inhibition of P-glycoprotein by cyclosporin A analogues and metabolites.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Endosomes; Models, Chemical; Photoaffinity Labels; Time Factors; Verapamil; Vinblastine | 1999 |
ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cerebellum; Colchicine; Cyclosporine; Cysteine Proteinase Inhibitors; Deoxyglucose; Dizocilpine Maleate; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Glutathione; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microtubules; Neurons; Neuroprotective Agents; Nitroso Compounds; Nocodazole; Oligopeptides; Paclitaxel; Potassium; Protein Biosynthesis; S-Nitrosoglutathione; Tacrolimus; Verapamil | 1999 |
The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Capsaicin; Cell Line; Cyclosporine; Gene Expression Regulation; Glycosylation; Hexosaminidases; Humans; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Membrane Proteins; Mutation; Nucleotides; Peptide Fragments; Protein Binding; Transfection; Trypsin; Verapamil; Vinblastine | 1999 |
Multidrug resistance modulation in vivo: the effect of cyclosporin A alone or with dexverapamil on idarubicin pharmacokinetics in acute leukemia.
Topics: Cyclosporine; Drug Resistance, Multiple; Drug Therapy, Combination; Humans; Idarubicin; Leukemia, Myeloid, Acute; Time Factors; Verapamil | 1999 |
Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin A biliary excretion and cholestasis: a study in isolated perfused rat liver.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; Bile; Cholestasis; Cyclosporine; Immunosuppressive Agents; Liver; Male; Perfusion; Rats; Rats, Wistar; Time Factors; Verapamil | 1999 |
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.
Topics: Animals; Annexin A5; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Cadmium Chloride; Calcium Channel Blockers; Cell Line; Cyclosporine; Cyclosporins; Enzyme Inhibitors; Fluoresceins; Kidney Tubules, Proximal; Kinetics; Necrosis; NF-kappa B; Oxidative Stress; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Time Factors; Up-Regulation; Verapamil | 2000 |
Individual or combined effects of enalapril and verapamil on chronic cyclosporine nephrotoxicity in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Cyclosporine; Drug Therapy, Combination; Enalapril; Endothelin-1; Gene Expression Regulation; Immunosuppressive Agents; Kidney Cortex; Male; Nephritis; Osteopontin; Procollagen; Rats; Rats, Wistar; RNA, Messenger; Sialoglycoproteins; Transforming Growth Factor beta; Verapamil | 1999 |
The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; Cell Line; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Cytoplasm; Disulfides; Enzyme Inhibitors; Humans; Membrane Proteins; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Temperature; Verapamil; Vinblastine | 2000 |
Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Drug Interactions; Enzyme Activation; Humans; Molecular Sequence Data; Phenylalanine; Photoaffinity Labels; Tritium; Tumor Cells, Cultured; Vanadates; Verapamil | 2000 |
Effects of antiadhesive agents on the healing of intestinal anastomosis.
Topics: Anastomosis, Surgical; Animals; Aprotinin; Carboxymethylcellulose Sodium; Colon; Cyclosporine; Dextrans; Injections, Intramuscular; Injections, Intraperitoneal; Intestines; Piroxicam; Rats; Rats, Wistar; Tissue Adhesions; Treatment Outcome; Verapamil; Vitamin E; Wound Healing | 2000 |
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.
Topics: Acetic Acid; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoic Acid; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carboxylic Acids; Carrier Proteins; Cell Polarity; Cyclosporine; Drug Interactions; Heptanoic Acids; Humans; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indicators and Reagents; Ionophores; Niacin; Protons; Pyrroles; Verapamil; Vinblastine | 2000 |
Strategies to antagonise the cyclosporine A-induced proliferation of human pulmonary artery smooth muscle cells: anti-endothelin-1 antibodies, verapamil, and octreotide.
Topics: Antibodies; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cyclosporine; Cyclosporins; Endothelin-1; Humans; Immunosuppressive Agents; Muscle, Smooth, Vascular; Octreotide; Pulmonary Artery; Vasoconstrictor Agents; Verapamil | 2000 |
Factors that affect absorption behavior of cyclosporin a in gentamicin-induced acute renal failure in rats.
Topics: Absorption; Acute Kidney Injury; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Bile Acids and Salts; Biological Availability; Cyclosporine; Drug Administration Routes; Drug Interactions; Enterocytes; Fluorescence Polarization Immunoassay; Gentamicins; Immunosuppressive Agents; Jejunum; Male; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Verapamil | 2000 |
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine | 2000 |
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine | 2000 |
Calcium antagonists potentiate P-glycoprotein-independent anticancer drugs in chronic lymphocytic leukemia cells in vitro.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; B-Lymphocytes; Calcium; Calcium Channel Blockers; Calcium Signaling; Chlorambucil; Cisplatin; Cladribine; Cyclosporine; DNA Fragmentation; Doxorubicin; Drug Synergism; Female; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Nifedipine; Prednisolone; Tumor Cells, Cultured; Verapamil; Vidarabine; Vincristine | 2000 |
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil | 2000 |
Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bivalvia; Cyclosporine; Mollusca; Multidrug Resistance-Associated Proteins; Species Specificity; Verapamil; Water Pollutants, Chemical; Xenobiotics | 2000 |
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Topics: Acetates; ATP Binding Cassette Transporter, Subfamily B; Beverages; Blotting, Western; Citrus; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavones; Flavonoids; Furocoumarins; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Plant Extracts; Tritium; Verapamil; Vincristine | 2000 |
Role of P glycoprotein in the course and treatment of Encephalitozoon microsporidiosis.
Topics: Acquired Immunodeficiency Syndrome; Albendazole; Animals; Anthelmintics; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Cells, Cultured; Chlorocebus aethiops; Cyclosporine; Encephalitozoon; Encephalitozoonosis; Fluoresceins; Genes, MDR; Immunohistochemistry; Immunosuppressive Agents; Verapamil | 2001 |
Structure-activity relationship of P-glycoprotein substrates and modifiers.
Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine | 2000 |
Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase.
Topics: Adenosine Triphosphate; Allosteric Regulation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Membrane; Chromatography, Liquid; Cyclosporine; Doxorubicin; Humans; Reference Standards; Tumor Cells, Cultured; Verapamil; Vinblastine | 2001 |
Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions.
Topics: Acute Kidney Injury; Anti-Arrhythmia Agents; Cyclosporine; Digoxin; Drug Interactions; Enzyme Inhibitors; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Male; Middle Aged; Rhabdomyolysis; Simvastatin; Verapamil | 2000 |
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Blotting, Western; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Erythromycin; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Rhodamine 123; Substrate Specificity; Verapamil | 2001 |
P-Glycoprotein conformational changes detected by antibody competition.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Nifedipine; Polysorbates; Protein Binding; Protein Conformation; Substrate Specificity; Tumor Cells, Cultured; Valinomycin; Verapamil; Vinblastine | 2001 |
Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia.
Topics: Acute Disease; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Death; Cell Survival; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Flow Cytometry; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; RNA, Messenger; Vault Ribonucleoprotein Particles; Verapamil | 2001 |
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Separation; Cyclosporine; Enzyme Inhibitors; Fluorescent Dyes; Humans; Immunosuppressive Agents; Lymphocytes; Quinidine; Rhodamine 123; Tacrolimus; Verapamil | 2001 |
Active transepithelial transport of irinotecan (CPT-11) and its metabolites by human intestinal Caco-2 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Biological Transport; Biotransformation; Caco-2 Cells; Camptothecin; Cell Survival; Chromatography, High Pressure Liquid; Cyclosporine; Humans; Intestinal Mucosa; Irinotecan; Quinolines; RNA, Messenger; Verapamil | 2001 |
Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cations; Cell Line; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Histidine; Humans; Organic Cation Transport Proteins; Rhodamine 123; Time Factors; Tritium; Tyramine; Verapamil; Vinblastine | 2001 |
Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cells, Cultured; Cricetinae; Cyclosporine; Drug Interactions; Drug Resistance; Drug Resistance, Multiple; Iodine Radioisotopes; Membrane Proteins; Mutagenesis, Site-Directed; Prazosin; Protein Structure, Tertiary; Transfection; Verapamil | 2001 |
Intra- and intercellular distribution of mitochondrial probes and changes after treatment with MDR modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cyclosporine; Drug Resistance, Multiple; Fluorescent Dyes; Humans; Mitochondria; Progesterone; Verapamil | 2001 |
Effect of chronic renal failure on the expression and function of rat intestinal P-glycoprotein in drug excretion.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Creatinine; Cyclosporine; Intestinal Mucosa; Jejunum; Kidney Failure, Chronic; Male; Mannitol; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rhodamine 123; RNA, Messenger; Verapamil | 2001 |
P-glycoprotein inhibitors stimulate renal phosphate reabsorption in rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cyclosporine; Dipyridamole; Glomerular Filtration Rate; Glucose; Kidney Tubules, Proximal; Male; Phosphates; Rats; Rats, Sprague-Dawley; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type III; Symporters; Up-Regulation; Verapamil | 2001 |
Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cyclosporine; Enzyme Inhibitors; Excipients; Fluorescent Dyes; Hepatocytes; Male; Octoxynol; Rats; Rats, Wistar; Rhodamine 123; Vanadates; Verapamil | 2001 |
Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Division; Colorectal Neoplasms; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Inhibitory Concentration 50; Intracellular Fluid; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2001 |
Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; Carcinoma, Hepatocellular; Cell Membrane Permeability; Cell Size; Cells, Cultured; Chlorides; Cyclosporine; Humans; Mice; Rats; Tumor Cells, Cultured; Verapamil | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
P glycoprotein regulated transport of glutamate at blood brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Cyclosporine; Drug Resistance, Multiple; Endothelium, Vascular; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Verapamil; Vincristine | 2001 |
Xenobiotic efflux pumps in isolated fish brain capillaries.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Dogfish; Enzyme Inhibitors; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Indicators and Reagents; Leukotriene C4; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Potassium Cyanide; Verapamil; Xenobiotics | 2002 |
Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Hepatocytes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; NADP; Permeability; Rats; Rats, Wistar; Sulfhydryl Compounds; Verapamil | 2002 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes.
Topics: Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Calcium Channel Blockers; Cyclosporine; Humans; Immunosuppressive Agents; Intestinal Mucosa; Steroids; T-Lymphocytes; Verapamil | 2002 |
Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Binding Sites; Blood-Brain Barrier; Brain; Capillaries; Cattle; Cell Membrane; Cell Separation; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Verapamil; Vincristine | 2002 |
[Reversal of multidrug-resistance in human leukemia cell line K562/A02 by a cyclosporin D analogue PSC 833].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; K562 Cells; RNA, Messenger; Verapamil | 2002 |
Real-time monitoring of P-glycoprotein activation in living cells.
Topics: 3T3 Cells; Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biosensing Techniques; Chloride-Bicarbonate Antiporters; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Extracellular Space; Humans; Hydrogen-Ion Concentration; LLC-PK1 Cells; Mice; Sodium-Hydrogen Exchangers; Substrate Specificity; Swine; Transfection; Trifluoperazine; Verapamil | 2002 |
Influence of chemosensitizers on resistance mechanisms in daunorubicin-resistant Ehrlich ascites tumour cells.
Topics: Animals; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Carcinoma, Ehrlich Tumor; Cyclosporine; Daunorubicin; DNA Primers; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 2002 |
Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Survival; Cyclosporine; Drug Resistance, Neoplasm; False Positive Reactions; Mammary Neoplasms, Experimental; Neoplasm Invasiveness; Puromycin; Reference Values; Selection, Genetic; Transfection; Tumor Cells, Cultured; Verapamil | 2002 |
Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cyclosporine; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Leukemia P388; Male; Mice; Tumor Cells, Cultured; Verapamil; Xanthines | 2002 |
Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.
Topics: Adenosine Triphosphate; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Benzoflavones; Biological Transport, Active; Caco-2 Cells; Cell Polarity; Cyclosporine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Enterocytes; Gene Expression; Humans; Models, Biological; Probenecid; Propionates; Quinolines; Verapamil; Vinblastine | 2003 |
The involvement of P-glycoprotein in berberine absorption.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Caco-2 Cells; Cells, Cultured; Cyclosporine; Humans; Intestinal Absorption; Rats; Verapamil | 2002 |
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Topics: Acridines; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cell Line; Cyclosporine; Cytosol; Gemfibrozil; Isoquinolines; Lysosomes; Macrophages; Mice; Microscopy, Confocal; Monensin; Probenecid; Tetrahydroisoquinolines; Verapamil | 2003 |
Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Catenin; Cell Division; Cyclosporine; Cytoskeletal Proteins; Gene Transfer Techniques; Genes, APC; Genes, MDR; Germ-Line Mutation; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Trans-Activators; Verapamil | 2003 |
Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation.
Topics: 3T3 Cells; Allosteric Site; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cell Line; Cell Membrane; Cyclosporine; Dopamine Antagonists; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epitopes; Flupenthixol; Humans; Immunoblotting; Mice; Plasmids; Protein Binding; Protein Conformation; Protein Transport; Spectrometry, Fluorescence; Substrate Specificity; Time Factors; Tumor Cells, Cultured; Verapamil | 2003 |
Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Caspase 3; Caspases; Cyclosporine; Cytochrome c Group; Cytoprotection; Diltiazem; Female; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Organometallic Compounds; Oxygen Consumption; Rats; Rats, Long-Evans; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium-Calcium Exchanger; Verapamil | 2003 |
Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Digoxin; Drug Interactions; In Vitro Techniques; Intestinal Absorption; Male; Medigoxin; Rats; Rats, Wistar; Verapamil | 2003 |
In vivo and in vitro multitracer analyses of P-glycoprotein expression-related multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorodeoxyglucose F18; Humans; Metabolic Clearance Rate; Mice; Mice, SCID; Radioisotope Dilution Technique; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tissue Distribution; Tomography, Emission-Computed; Verapamil | 2003 |
UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines.
Topics: Apoptosis; ATP-Binding Cassette Transporters; Cell Death; Cell Line; Cyclosporine; Cytoplasm; Flow Cytometry; Humans; Lymphocytes; Phenotype; Probenecid; Radiation Dosage; Radiation, Ionizing; Rhodamines; Sulfinpyrazone; Tumor Cells, Cultured; Ultraviolet Rays; Verapamil; X-Rays | 2003 |
Pumping of drugs by P-glycoprotein: a two-step process?
Topics: Algorithms; Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cyclosporine; Daunorubicin; Fluoresceins; Humans; Immunosuppressive Agents; Kinetics; Models, Biological; Pharmaceutical Preparations; Quinolines; Verapamil; Vinblastine | 2003 |
Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.
Topics: Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Calcium Channels; Cyclosporine; Cyclosporins; Diphenoxylate; Drug Interactions; Humans; Loperamide; Narcotics; Probenecid; Sulfinpyrazone; Verapamil | 2003 |
P-glycoprotein inhibitors modulate accumulation and efflux of xenobiotics in extra and intracellular Toxoplasma gondii.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Biological Transport, Active; Carbocyanines; Cell Line; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Fluorescent Dyes; Humans; Membrane Transport Proteins; Protozoan Proteins; Toxoplasma; Vacuoles; Verapamil; Xenobiotics | 2004 |
Mitotracker green is a P-glycoprotein substrate.
Topics: Aldehydes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Size; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescence; Fluorescent Dyes; Humans; K562 Cells; Mitochondria; Rhodamine 123; Time Factors; Trifluoperazine; Verapamil | 2003 |
Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs.
Topics: Animals; Antineoplastic Agents; Biological Transport; Caco-2 Cells; Camptothecin; Cyclosporine; Duodenum; Humans; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Verapamil | 2004 |
Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor-beta prior to renal fibrosis: Modification by calcium channel blockade in the salt replete rat.
Topics: Animals; Cyclosporine; DNA; DNA Fragmentation; Fibrosis; Gene Expression Regulation; Genes, Immediate-Early; Immunosuppressive Agents; Kidney; Male; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Verapamil | 2004 |
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cation Transport Proteins; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Cyclosporine; Endothelial Cells; Fluorescein; Membrane Potentials; Mice; Prion Diseases; Quinacrine; Tetraethylammonium; Verapamil | 2004 |
[Idiopathic membranous nephropathy associated with anti-calcineurin toxicity. Prognosis and other immunosuppressive treatments].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcineurin Inhibitors; Calcium Channel Blockers; Creatinine; Cyclosporine; Drug Therapy, Combination; Glomerulonephritis, Membranous; Humans; Hypercholesterolemia; Hypertension; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Diseases; Lisinopril; Lovastatin; Male; Nephrotic Syndrome; Prednisone; Recurrence; Verapamil | 2004 |
The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Buffers; Cell Line; Colchicine; Cyclosporine; Cysteine; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Hydrolysis; Isoleucine; Mesylates; Mutation; Rhodamines; Verapamil; Water | 2004 |
Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Blood-Brain Barrier; Calcium Channel Blockers; Capillaries; Cerebrovascular Circulation; Cyclosporine; Doxorubicin; Drug Synergism; Endothelial Cells; Fluorescent Dyes; Immunosuppressive Agents; Pharmaceutical Preparations; Rats; Rhodamine 123; Verapamil | 2004 |
[The in vitro kinetics of uptake, transport and efflux of 9-nitrocamptothecin in Caco-2 cell model].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Camptothecin; Cyclosporine; Humans; Hydrogen-Ion Concentration; Temperature; Verapamil | 2004 |
Biphasic accumulation kinetics of [99mTc]-hexakis-2-methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cricetinae; Cyclosporine; Drug Resistance, Multiple; Fluorine Radioisotopes; Gluconates; Humans; Intracellular Membranes; Ligands; Membrane Fluidity; Membrane Potentials; Mice; Mitochondria; Permeability; Rhodamine 123; Technetium Tc 99m Sestamibi; Verapamil | 2005 |
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Calcium Channel Blockers; Cyclosporine; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Verapamil | 2005 |
Transport characteristics of rutin deca (H-) sulfonate sodium across Caco-2 cell monolayers.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cyclosporine; Drug Interactions; Flavones; Humans; Hydrogen-Ion Concentration; Models, Biological; Rhodamine 123; Rutin; Temperature; Verapamil | 2005 |
Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Rats; Rats, Sprague-Dawley; Verapamil | 2006 |
Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cardiotonic Agents; Cyclosporine; Digoxin; Immunosuppressive Agents; Intestinal Absorption; Intestine, Small; Jejunum; Methylprednisolone; Progesterone; Rats; Tacrolimus; Verapamil; Vinblastine | 2006 |
Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Colchicine; Cricetinae; Cyclosporine; Demecolcine; Disulfides; Dithiothreitol; Fluoresceins; Flupenthixol; Humans; Mesylates; Point Mutation; Protein Structure, Tertiary; Verapamil; Vinblastine | 2006 |
Influence of Verapamil and Cyclosporin A on bile acid metabolism and transport in rat liver slices.
Topics: Animals; Animals, Outbred Strains; Biological Transport; Cholic Acids; Chromatography, High Pressure Liquid; Cyclosporine; Drug Combinations; In Vitro Techniques; Liver; Male; Rats; Rats, Wistar; Taurochenodeoxycholic Acid; Verapamil | 2006 |
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction.
Topics: Acetanilides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Fluorescent Dyes; Humans; Immunosuppressive Agents; Kidney; Pyrroles; Quinine; Quinolines; Rhodamines; Sirolimus; Verapamil | 2006 |
The influence of P-glycoprotein on cerebral and hepatic concentrations of nortriptyline and its metabolites.
Topics: Adenosine Triphosphatases; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Liver; Male; Methadone; Mice; Mice, Knockout; Nortriptyline; Rats; Rats, Wistar; Verapamil | 2006 |
Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbon Radioisotopes; Cyclosporine; Immunosuppressive Agents; Isotope Labeling; Male; Models, Statistical; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Verapamil | 2006 |
In vitro tests to evaluate immunotoxicity: a preliminary study.
Topics: Animals; Benzo(a)pyrene; CD3 Complex; Cell Proliferation; Cell Survival; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; Furosemide; Humans; Immunotoxins; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phytohemagglutinins; Rats; Reproducibility of Results; Spleen; T-Lymphocytes; Toxicity Tests; Trialkyltin Compounds; Urethane; Verapamil | 2007 |
Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Daunorubicin; Digoxin; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Quinidine; Rats; Species Specificity; Verapamil | 2007 |
[The effect of tetramethylpyrazine on the pharmacokinetics of intragastrically administered cyclosporine A in rats].
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Routes; Immunosuppressive Agents; Ligusticum; Male; Plants, Medicinal; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stomach; Verapamil | 2006 |
Identification of small signalling molecules promoting cardiac-specific differentiation of mouse embryonic stem cells.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Biomarkers; Calcineurin Inhibitors; Calcium Channel Blockers; Cell Differentiation; Colforsin; Cyclosporine; Embryonic Stem Cells; GATA4 Transcription Factor; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Mice; Mice, Transgenic; Myocytes, Cardiac; Myosin Heavy Chains; Platelet Endothelial Cell Adhesion Molecule-1; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Transcription Factors; Verapamil | 2006 |
Genetics. SNPs, silent but not invisible.
Topics: Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Codon; Cyclosporine; Genes, MDR; Haplotypes; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Biosynthesis; Protein Conformation; Protein Folding; RNA, Messenger; Verapamil | 2007 |
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane; Chlorocebus aethiops; Codon; Cyclosporine; Genes, MDR; Haplotypes; HeLa Cells; Humans; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Biosynthesis; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Sirolimus; Substrate Specificity; Transfection; Verapamil | 2007 |
In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cyclosporine; Donepezil; Flumazenil; Indans; Ligands; Male; Mice; Piperidines; Positron-Emission Tomography; Radioisotopes; Sensory Receptor Cells; Verapamil; Xanthines | 2007 |
In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxacin; Colon; Cyclosporine; Dose-Response Relationship, Drug; Fluoroquinolones; Immunosuppressive Agents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Models, Biological; Molecular Structure; Muscarinic Antagonists; p-Aminohippuric Acid; Permeability; Quinidine; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2007 |
Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carbazoles; Carvedilol; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunosuppressive Agents; Injections, Intravenous; Intestinal Absorption; Male; Propanolamines; Rats; Rats, Wistar; Verapamil | 2007 |
Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells.
Topics: Adenosine Triphosphatases; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Cell Membrane; Colchicine; Cyclosporine; Dammaranes; Daunorubicin; Drug Resistance, Neoplasm; Ginsenosides; Humans; Hydrolysis; KB Cells; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship; Triterpenes; Verapamil | 2007 |
Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Verapamil | 2008 |
An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat.
Topics: Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport, Active; Cyclosporine; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Intestinal Absorption; Ketoconazole; Lymphatic System; Male; Micelles; Rats; Rats, Wistar; Saquinavir; Triglycerides; Triolein; Verapamil | 2008 |
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.
Topics: Adamantane; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Cell Polarity; Cyclosporine; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Enzyme Inhibitors; Fluorescent Dyes; Golgi Apparatus; Humans; Intestinal Mucosa; Neoplasms; Protein Binding; Protein Structure, Secondary; Protein Synthesis Inhibitors; Protein Transport; Rhodamine 123; Shiga Toxins; Time Factors; Trihexosylceramides; Up-Regulation; Verapamil; Vinblastine | 2008 |
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Carbamates; Carbon Radioisotopes; Cyclosporine; Drug Interactions; Fluorescent Dyes; Furans; Humans; LLC-PK1 Cells; Positron-Emission Tomography; Quinidine; Quinine; Rats; Sulfonamides; Swine; Verapamil | 2008 |
A new role for extracellular Ca2+ in gap-junction remodeling: studies in humans and rats.
Topics: Animals; Atrial Fibrillation; Calcium; Cells, Cultured; Connexin 43; Connexins; Cyclosporine; Female; Gap Junction alpha-5 Protein; Gap Junctions; Humans; Male; Middle Aged; Rats; Rats, Wistar; Signal Transduction; Verapamil | 2008 |
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil | 2008 |
Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Biological Transport, Active; Brain; Brain Chemistry; Carbon Radioisotopes; Celecoxib; Cyclosporine; Male; Positron-Emission Tomography; Pyrazoles; Radioligand Assay; Radiopharmaceuticals; Rats; Rats, Wistar; Sulfonamides; Tissue Distribution; Verapamil | 2008 |
An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil.
Topics: Animals; Bile; Cyclosporine; Drug Interactions; Glycosides; Microdialysis; Plant Extracts; Pyrans; Rats; Rats, Sprague-Dawley; Scrophularia; Verapamil | 2009 |
PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier--lack of influence of cyclosporin and probenecid.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyurea; Male; Mannitol; Positron-Emission Tomography; Probenecid; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2007 |
Dual potency anti-HER2/neu and anti-EGFR anthracycline immunoconjugates in chemotherapeutic-resistant mammary carcinoma combined with cyclosporin A and verapamil P-glycoprotein inhibition.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cyclosporine; Drug Resistance, Neoplasm; Epirubicin; ErbB Receptors; Female; Humans; Immunoconjugates; Immunoglobulin G; Receptor, ErbB-2; Verapamil | 2009 |
Transport characteristics of candesartan in human intestinal Caco-2 cell line.
Topics: Angiotensin II Type 1 Receptor Blockers; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Biological Transport, Active; Biphenyl Compounds; Caco-2 Cells; Calcium Channel Blockers; Carrier Proteins; Chromatography, High Pressure Liquid; Cyclosporine; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Tetrazoles; Verapamil | 2009 |
CJX1, an amlodipine derivative, interacts with ATPase of human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amlodipine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Calcium Channel Blockers; Cell Line, Tumor; Cyclosporine; Hematologic Neoplasms; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Verapamil | 2009 |
Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans.
Topics: Adult; Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Computer Simulation; Cyclosporine; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Radionuclide Imaging; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Verapamil; Young Adult | 2009 |
Detergents as intrinsic P-glycoprotein substrates and inhibitors.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Biological Transport; Cell Membrane; Cyclosporine; Detergents; Embryo, Mammalian; Enzyme Inhibitors; Fibroblasts; Kinetics; Membrane Lipids; Mice; Micelles; Verapamil | 2009 |
Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism.
Topics: Aconitine; Administration, Oral; Animals; Biological Transport; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Glycyrrhizic Acid; Intestinal Absorption; Male; Membrane Transport Proteins; Nitrophenols; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil | 2009 |
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosporine; Kidney; Liver; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Tetraethylammonium; Verapamil | 2009 |
Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cyclosporine; Female; Gestational Age; Macaca nemestrina; Maternal-Fetal Exchange; Organ Specificity; Placenta; Positron-Emission Tomography; Pregnancy; Pregnancy, Animal; Radiopharmaceuticals; Verapamil | 2010 |
Effect of HEPES buffer on the uptake and transport of P-glycoprotein substrates and large neutral amino acids.
Topics: Adenosine Triphosphate; Amino Acids, Neutral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Membrane Permeability; Cyclosporine; Dogs; Glutamic Acid; HEPES; Humans; Lopinavir; Phenylalanine; Pyrimidinones; Ritonavir; Verapamil | 2010 |
Iodination increases the activity of verapamil derivatives in reversing PGP multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Cycle; Cyclosporine; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; K562 Cells; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2010 |
Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Benzimidazoles; Cell Line, Tumor; Cisplatin; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Microscopy, Fluorescence; Verapamil; Xenograft Model Antitumor Assays | 2010 |
Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Dreissena; Drug Resistance, Multiple; Drug Tolerance; Embryo, Nonmammalian; Indans; Larva; Oligopeptides; Propionates; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; Risk Assessment; Verapamil; Xenobiotics | 2011 |
Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cell Survival; Ceramides; Cyclosporine; Cytotoxins; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Tamoxifen; Uterine Cervical Neoplasms; Verapamil | 2010 |
Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A: modulation of P-glycoprotein function.
Topics: Adult; Arthritis, Psoriatic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Sedimentation; C-Reactive Protein; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Drug Resistance; Female; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Rhodamine 123; Sulfasalazine; T-Lymphocytes; Treatment Outcome; Verapamil | 2011 |
Micellar electrokinetic chromatographic analysis for in vitro accumulation of anthracyclines enhanced by inhibitors of cell membrane transporter-proteins in cancer cells.
Topics: Biological Transport, Active; Cell Line, Tumor; Cellular Structures; Chromatography, Micellar Electrokinetic Capillary; Cyclosporine; Daunorubicin; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Probenecid; Verapamil | 2011 |
Nasal delivery of P-gp substrates to the brain through the nose-brain pathway.
Topics: Administration, Intranasal; Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cyclosporine; Infusions, Intravenous; Male; Perfusion; Propanolamines; Rats; Rats, Sprague-Dawley; Verapamil | 2011 |
Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Berberine Alkaloids; Biological Transport; Caco-2 Cells; Cyclosporine; Drugs, Chinese Herbal; Humans; Intestinal Absorption; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Verapamil | 2011 |
Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Colchicine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; HT29 Cells; Humans; Inhibitory Concentration 50; Mutagenesis, Site-Directed; Polyethylene Glycols; Verapamil | 2011 |
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cyclosporine; Doxorubicin; Enzyme Inhibitors; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Oxidative Stress; Prazosin; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, beta-2; Signal Transduction; Survival Rate; Verapamil | 2011 |
Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms.
Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Cyclosporine; Dogs; Ginsenosides; Humans; Male; Mice; Mice, Knockout; Solubility; Stereoisomerism; Tumor Cells, Cultured; Verapamil | 2011 |
Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Fluorouracil; Humans; Indicators and Reagents; Liver Neoplasms; Mice; Rhodamine 123; Tumor Cells, Cultured; Verapamil; Xenograft Model Antitumor Assays | 2011 |
HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation.
Topics: Calcimycin; Calcium; Calcium Channel Blockers; Calcium Ionophores; Calpain; Caspase 3; Cyclosporine; Dantrolene; Enzyme Inhibitors; Flunarizine; Humans; Hypochlorous Acid; Lysosomes; Macrophages; Membrane Potential, Mitochondrial; Muscle Relaxants, Central; Necrosis; Nifedipine; Verapamil | 2012 |
Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Female; Gene Knockdown Techniques; Male; Mice; Multidrug Resistance-Associated Proteins; Ovum; Parasite Load; Quinolines; RNA Interference; Schistosoma mansoni; Verapamil | 2011 |
Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.
Topics: Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blood-Brain Barrier; Cyclosporine; Desipramine; Drug Interactions; Extracellular Fluid; Half-Life; Imipramine; Injections, Intravenous; Male; Metabolic Clearance Rate; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2012 |
Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood-brain barrier in in vitro cell experiments.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cyclosporine; Dose-Response Relationship, Drug; Flavanones; Neuroprotective Agents; Rats; Rhodamine 123; Verapamil | 2012 |
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Topics: Animals; Bosentan; Capillary Permeability; Chromatography, Liquid; Cyclosporine; Dogs; Fluorobenzenes; Hepatocytes; Madin Darby Canine Kidney Cells; Male; Metabolic Clearance Rate; Pyrimidines; Quinidine; Rats; Rats, Sprague-Dawley; Rifampin; Rosuvastatin Calcium; Sulfonamides; Tandem Mass Spectrometry; Verapamil; Xenobiotics | 2012 |
Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Cyclosporine; Female; Fluoresceins; Gene Expression; Male; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Olfactory Mucosa; Olfactory Receptor Neurons; Probenecid; Propionates; Quinolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Verapamil | 2012 |
Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Age Factors; Aged; Biological Transport; Cells, Cultured; Cold Temperature; Cyclosporine; Female; Gestational Age; Hepatocytes; Humans; Hydroxyprogesterones; Kinetics; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Protein 2; Rifampin; RNA, Messenger; Taurocholic Acid; Verapamil; Young Adult | 2013 |
The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells.
Topics: Aconitine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cyclosporine; Diketopiperazines; Dogs; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Madin Darby Canine Kidney Cells; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Propionates; Quinolines; Transfection; Verapamil | 2013 |
P-glycoprotein is fully active after multiple tryptophan substitutions.
Topics: Adenosine Triphosphatases; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Crystallography, X-Ray; Cyclosporine; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Humans; Models, Molecular; Molecular Conformation; Mutation; Protein Binding; Saccharomyces cerevisiae; Tacrolimus; Tryptophan; Valinomycin; Verapamil | 2013 |
Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cyclosporine; Female; Fetus; Humans; Ligands; Liver; Macaca nemestrina; Models, Biological; Placenta; Positron-Emission Tomography; Pregnancy; Tissue Distribution; Verapamil | 2013 |
Transcellular transport of aconitine across human intestinal Caco-2 cells.
Topics: Aconitine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cyclosporine; Dose-Response Relationship, Drug; Glucose; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Sodium; Temperature; Transcytosis; Verapamil | 2013 |
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cyclosporine; Drug Resistance, Multiple; High-Throughput Screening Assays; Humans; Quinolines; Reproducibility of Results; Verapamil | 2013 |
P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents.
Topics: Animals; Antidepressive Agents, Second-Generation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Brain; Citalopram; Cyclosporine; Dogs; Drug Interactions; Humans; Madin Darby Canine Kidney Cells; Male; Mice; Rats; Verapamil | 2013 |
Combination therapy to reduce conjunctival scarring after glaucoma surgery.
Topics: Alkylating Agents; Apoptosis; Calcium Channel Blockers; Cicatrix; Conjunctival Diseases; Cyclosporine; Drug Therapy, Combination; Enzyme Inhibitors; Fibroblasts; Filtering Surgery; Glaucoma; Humans; Mitomycin; Postoperative Complications; Staurosporine; Tenon Capsule; Verapamil | 2013 |
A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human.
Topics: Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 CYP3A; Drug Interactions; Gastric Mucosa; Humans; Intestine, Small; Liver; Microsomes, Liver; Midazolam; Models, Biological; Simvastatin; Stereoisomerism; Verapamil | 2013 |
Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; CD13 Antigens; Cell Proliferation; Cyclosporine; Dogs; Humans; Immunologic Factors; Intestinal Absorption; Intestinal Mucosa; Intestines; K562 Cells; Leucine; Madin Darby Canine Kidney Cells; Male; Rats, Wistar; U937 Cells; Verapamil | 2013 |
Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Cyclosporine; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Mice; Resveratrol; Rhodamine 123; Skin Neoplasms; Stilbenes; Triterpenes; Ursolic Acid; Verapamil | 2013 |
Enhanced oral bioavailability of paclitaxel by concomitant use of absorption enhancers and P-glycoprotein inhibitors in rats.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cyclosporine; Ibuprofen; Male; Paclitaxel; Permeability; Rats; Rats, Sprague-Dawley; Solubility; Verapamil | 2013 |
P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies.
Topics: Aconitine; Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Cyclosporine; Drug Interactions; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Plant Extracts; Protein Conformation; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Verapamil | 2013 |
Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Cells, Cultured; Cyclosporine; Humans; Male; Nelfinavir; Rats; Rats, Sprague-Dawley; Verapamil | 2014 |
Multilayer spheroids to quantify drug uptake and diffusion in 3D.
Topics: ATP Binding Cassette Transporter, Subfamily B; Carbenoxolone; Cell Line; Cell Line, Tumor; Cyclosporine; Diffusion; Fluoresceins; HEK293 Cells; Humans; Loperamide; MCF-7 Cells; Pharmaceutical Preparations; Spheroids, Cellular; Verapamil | 2014 |
Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cyclosporine; Dog Diseases; Dogs; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Animal; Verapamil; Vinblastine | 2014 |
Uptake of compounds that selectively kill multidrug-resistant cells: the copper transporter SLC31A1 (CTR1) increases cellular accumulation of the thiosemicarbazone NSC73306.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cation Transport Proteins; Chlorocebus aethiops; Cisplatin; Copper; Copper Transporter 1; COS Cells; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Indoles; Inhibitory Concentration 50; LLC-PK1 Cells; Reproducibility of Results; RNA, Small Interfering; Swine; Thiosemicarbazones; Verapamil | 2014 |
P-glycoprotein expression in Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins.
Topics: Acetanilides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cloning, Molecular; Cyclosporine; Dinoflagellida; DNA Primers; DNA, Complementary; Gills; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Perna; Pyrroles; Quinolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Verapamil | 2014 |
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Cell Survival; Clarithromycin; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Erythromycin; Female; Gene Expression; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice, Nude; Molecular Targeted Therapy; Tumor Burden; Verapamil; Xenograft Model Antitumor Assays | 2015 |
Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Topics: 1-Methyl-4-phenylpyridinium; Amantadine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Cyclosporine; Ion Pumps; Male; Microinjections; Quinidine; Rats; Rhodamine 123; Tritium; Verapamil | 2015 |
Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cyclosporine; Furosemide; Humans; Inhibitory Concentration 50; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocytes; Mannitol; Toxicity Tests; Trialkyltin Compounds; Tumor Necrosis Factor-alpha; Urethane; Verapamil; Xenobiotics | 2015 |
Study on the pharmacokinetics profiles of polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Chromatography, Liquid; Cyclosporine; Diosgenin; Humans; Male; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Verapamil | 2015 |
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil | 2015 |
(R)-[¹¹C]Emopamil as a novel tracer for imaging enhanced P-glycoprotein function.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Carbon Radioisotopes; Cyclosporine; Male; Mice; Positron-Emission Tomography; Rats; Stereoisomerism; Tissue Distribution; Verapamil | 2016 |
Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy.
Topics: Adult; Biomarkers; Cyclosporine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Verapamil | 2016 |
Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cell Culture Techniques; Cell Survival; Cyclosporine; Drug Evaluation, Preclinical; Humans; Quinidine; Verapamil | 2016 |
CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats.
Topics: Animals; Biological Factors; Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Drug Interactions; Gene Expression Regulation, Enzymologic; Immunosuppressive Agents; Kidney; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Vasodilation; Verapamil | 2017 |
[Absorption characteristics of 5 components of Xinshao extract in Caco-2 cells].
Topics: Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Caffeic Acids; Cyclosporine; Drugs, Chinese Herbal; Glucuronates; Humans; Intestinal Absorption; Verapamil | 2016 |
The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cyclosporine; Host-Parasite Interactions; Interleukin-4; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Nematospiroides dubius; NF-kappa B; Quinolines; Strongylida Infections; T-Lymphocyte Subsets; Verapamil | 2017 |
P-gp is involved in the intestinal absorption and biliary excretion of afatinib in vitro and in rats.
Topics: Adenosine Triphosphatases; Afatinib; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Cyclosporine; Hepatobiliary Elimination; Hepatocytes; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Quinazolines; Rats; Rats, Wistar; Verapamil | 2018 |
Effect of synergists on ivermectin resistance in field populations of Rhipicephalus (Boophilus) microplus from Punjab districts, India.
Topics: Animals; Cyclosporine; India; Insecticide Resistance; Ivermectin; Larva; Propionates; Quinolines; Rhipicephalus; Verapamil | 2018 |
Molecular basis of the counteraction by calcium channel blockers of cyclosporine nephrotoxicity.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Calcium Channel Blockers; Collagen Type IV; Creatinine; Cyclosporine; Dual Oxidases; Fibrosis; Inflammation Mediators; Kidney; Kidney Diseases; Male; NADPH Oxidases; NF-kappa B; Nifedipine; Oxidative Stress; Proteinuria; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1; Verapamil | 2018 |
Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Carbocyanines; Cell Line; Cyclosporine; Fluorescent Dyes; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Quinolines; Verapamil | 2018 |
Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Topics: Acyclovir; Animals; Biological Transport; Biomarkers; Bone Morphogenetic Protein 7; Carrier Proteins; Cell Culture Techniques; Cell Line, Transformed; Cell Lineage; Cimetidine; Cisplatin; Cyclic AMP; Cyclosporine; Digoxin; Doxorubicin; Drug Evaluation, Preclinical; Endocytosis; Extracellular Matrix; gamma-Glutamyltransferase; Humans; Kidney; Mice; Spheroids, Cellular; Toxicity Tests; Verapamil | 2019 |