verapamil and colchicine

verapamil has been researched along with colchicine in 134 studies

Research

Studies (134)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (9.70)	18.7374
1990's	62 (46.27)	18.2507
2000's	35 (26.12)	29.6817
2010's	23 (17.16)	24.3611
2020's	1 (0.75)	2.80

Authors

Authors	Studies
Bebawy, M; Morris, MB; Roufogalis, BD	2
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Thakker, DR; Troutman, MD	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Kashiwada, Y; Sekiya, M; Takaishi, Y; Taniguchi, M; Xiong, J; Yamagishi, T	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ahn, S; Chen, J; Dalton, JT; Li, W; Lu, Y; Miller, DD; Wang, J	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Alam, MA; Drewes, LR; Gurrapu, S; Jonnalagadda, SK; Lueth, EA; Mereddy, VR; Nelson, GL; Ronayne, CT; Solano, LN	1
Abouf, M; Abutaleb, NS; Chen, L; Elsebaei, MM; Ghiaty, A; Hegazy, YA; Malwal, SR; Mayhoub, AS; Mohammad, H; Oldfield, E; Seleem, MN; Zhang, J	1
Ai, W; Bao, N; Chen, H; Li, S; Li, W; Wang, S	1
Arnst, KE; Chen, H; Kumar, G; Li, W; Ma, D; Miller, DD; Wang, Q; Wang, Y; White, SW; Wu, Z; Yang, J	1
Glässer, D; Iwig, M; Rattke, W	1
Kobayashi, DV; Moriya, K; Numano, F; Shimamoto, T; Takahashi, T	1
Arias, IM; Gatmaitan, Z; Hsing, S	1
Gaertig, J; Gorovsky, MA; Heruth, DP; Stargell, LA	1
Abraham, I; Chauhan, SS; Chin, KV; Gottesman, MM; Krolczyk, AJ; Pastan, I; Sampson, KE; Schimmer, B; Wong, M	1
Bruggemann, EP; Currier, SJ; Gottesman, MM; Pastan, I	1
de Lannoy, IA; Silverman, M	1
Nicholson, GC; Papadimitriou, JM; Wood, DJ; Zheng, MH	1
Currier, SJ; Gottesman, MM; Haugland, RP; Pastan, I; Thiebaut, F; Whitaker, J; Willingham, MC	1
Fox, NE; Twentyman, PR; Wright, KA	1
Koch, G; Reeve, JG; Twentyman, PR; Wright, KA	1
Andreeff, M; Howell, SB; Shalinsky, DR	1
Clodfelter, K; Coon, JS; Knudson, W; Lu, B; Weinstein, RS	1
Khalbuss, WE; Wondergem, R	1
Ayala, P; Orozco, E; Samuelson, J; Wirth, D	2
Assaraf, YG; Molina, A; Schimke, RT; Sherwood, SW	1
Keilhauer, G; Lechner, C; Ludwig, H; Pirker, R; Raschack, M	1
Escalante, B; Reyes, JL	1
Barlow, SB; Cabral, F; Schibler, MJ	1
Dion, P; Horvath, J; Sircar, S; Weber, JM	1
Nito, S	1
Racker, E; Westcott, D; Wu, LT	1
Beck, WT; Cirtain, MC; Danks, MK; Felsted, RL; Safa, AR; Suttle, DP; Trent, JM; Wolverton, JS	1
Borish, L; Rocklin, R; Rosenbaum, R	1
Iida, H; Tsuruo, T	1
Cano-Gauci, DF; Riordan, JR	1
Anderson, M; Brewer, F; Fergusson, J; Warr, JR	1
Evensen, SA; Galdal, KS; Nilsen, E	1
Chu, F; Cowman, AF; Gros, P; Karcz, S; Schurr, E; van Es, HH; Vidal, S	1
Chumakov, PM; Grigorian, IA; Kopnin, BP; Ossovskaya, VS; Rybalkina, EY; Stromskaya, TP	1
Davey, MW; Davey, RA; Kidman, AD; Marks, DC	1
Clarke, DM; Loo, TW	8
Senior, AE; Urbatsch, IL	1
Aksentijevich, I; Cardarelli, CO; Gottesman, MM; Pastan, I	1
Doige, CA; Sharom, FJ; Yu, X	1
Belehradek, J; Garrigos, M; Mir, LM; Orlowski, S	1
Barnhill, MA; Frazier, DL; Jones, E; Lothrop, CD; Lu, X; Mishu, L; Niemeyer, G	1
Bear, CE	1
Bourgeois, S; Gruol, DJ; Trotter, J; Zee, MC	1
Georges, E; Nare, B; Prichard, RK	1
Beery, E; Halabe, E; Kornfeld, J; Landau, O; Nordenberg, J; Novogrodsky, A; Shafran, M; Sidi, Y; Wasserman, L	1
Hill, BT; Hosking, LK; McClean, S	1
De Bruijn, EA; Durante, NM; Eggermont, AM; Gheuens, EE; Marquet, RL; Van de Vrie, W; Van Oosterom, AT	1
Stow, MW; Vickers, SE; Warr, JR	1
Bourgeois, S; Gruol, DJ; Newby, RF; Rajah, FM	1
Elend, M; Fenton, JA; Quinn, D; Warr, JR	1
Parekh, H; Simpkins, H	1
Balkenende, AY; Slaper-Cortenbach, IC; van den Berg, H; van der Schoot, CE; Van Leeuwen, EF; Vervoordeldonk, SF; von dem Borne, AE	1
Bamberger, U; Georges, E; Heckel, A; Lheureux, F; Liu, Z; Pouliot, JF	1
Chao, CC	1
Ayala, P; Gómez, MD; Orozco, E; Pérez, DG; Samuelson, J	1
Drion, N; Lefauconnier, JM; Lemaire, M; Scherrmann, JM	1
Hevér-Szabó, A; Pirity, M; Venetianer, A	1
Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M	1
Clayman, RV; Ratliff, TL; Soble, JJ; Wolf, JS	1
Aran, JM; Gottesman, MM; Licht, T; Pastan, I	1
Chanez, C; Cholet, N; Drion, N; Risede, P; Scherrmann, JM	1
Ambudkar, SV; Cardarelli, CO; Pashinsky, I; Stein, WD	1
Litman, T; Skovsgaard, T; Stein, WD; Zeuthen, T	1
Abbott, NJ; Begley, DJ; Jezequel, SG; Khan, EU; Reichel, A; Roffey, SJ	1
Boval, B; Chappey, O; Declèves, X; Niel, E; Scherrmann, JM	1
Levine, LA	2
Ambudkar, SV; Cardarelli, C; Lelong, IH; Zhang, J	1
Horton, JK; Reuss, L; Vanoye, CG	1
Ben-Chetrit, E; Levy, M	1
Chan, MW; Chiang, CD; Song, EJ; Yang, VC	1
Gujaeva, EL; Kobliakov, VA; Rybalkina, EJ; Stravrovskaya, AA; Zabotina, TN	1
Leist, M; Nicotera, P; Volbracht, C	1
Gil, L; Martínez Morillo, M; Ruiz Gómez, MJ; Souviron, A	2
Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T	1
Anderson, MS; Lubrano, T; Mulhall, JP; Shankey, TV	1
Landwojtowicz, E; Seelig, A	1
Bible, KC; Boerner, SA; Kaufmann, SH; Tourne, ME	1
Chai, H; Cui, B; Hollingshead, MG; Kinghorn, AD; Lantvit, D; Lim, E; Mayo, JG; Mi, Q; Pezzuto, JM; Silva, GL; You, M	1
Cisternino, S; Dagenais, C; Rousselle, C; Scherrmann, JM	1
Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K	1
Hendrikse, NH; Vaalburg, W	1
Bartlett, MC; Clarke, DM; Loo, TW	3
Al-Shawi, MK; Figler, RA; Omote, H; Polar, MK	1
Minhas, S; Ralph, DJ	1
Cisternino, S; Debray, M; Rousselle, C; Scherrmann, JM	1
Bode-Böger, SM; Lins, H; Scherrmann, JM; Tröger, U; Wallesch, CW	1
Hasegawa, H; Kitagawa, S; Nabekura, T; Tachikawa, E; Takahashi, T	1
Amidon, GL; Dahan, A	1
Pollack, GM; Zhao, R	1
Amidon, GL; Dahan, A; Sabit, H	1
Gur, S; Hellstrom, WJ; Limin, M	1
Bebawy, M; Duke, CC; Duke, RK; Marks, D; Roufogalis, BD; Tran, VH	1
Bosia, A; Corsetto, PA; Costamagna, C; Enrico, E; Ghigo, D; Kopecka, J; Montorfano, G; Riganti, C; Rizzo, AM; Voena, C	1
Brancato, T; Paulis, G	1
Ceban, E; Geavlete, P; Halal, AA	1
Covell, DG	1
Dekel, Y; Stein, A	1
Carson, CC; Jordan, GH; Lipshultz, LI	1
Georges, E; Limniatis, G	1

Reviews

10 review(s) available for verapamil and colchicine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Physiology and molecular biology of multidrug resistance in Entamoeba histolytica. Archives of medical research, 1996,Autumn, Volume: 27, Issue:3 Topics: Amebicides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Colchicine; Consensus Sequence; Drug Resistance, Multiple; Entamoeba histolytica; Genes, Protozoan; Humans; Leishmania; Mice; Molecular Sequence Data; Open Reading Frames; Phylogeny; Plasmodium; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; Sequence Alignment; Sequence Homology, Nucleic Acid; Species Specificity; Verapamil	1996
Advances in the medical therapy of Peyronie's disease: a brief review. International journal of impotence research, 1998, Volume: 10, Issue:2 Topics: Colchicine; Collagenases; Humans; Male; Penile Induration; Verapamil	1998
Imaging of P glycoprotein function in vivo with PET. Novartis Foundation symposium, 2002, Volume: 243 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Colchicine; Daunorubicin; Drug Resistance, Multiple; Electrons; Humans; Mice; Neoplasm Proteins; Tomography, Emission-Computed; Verapamil	2002
Review of current nonsurgical management of Peyronie's disease. International journal of impotence research, 2003, Volume: 15 Suppl 5 Topics: Antioxidants; Calcium Channel Blockers; Colchicine; Collagenases; Drug Therapy, Combination; Humans; Male; Penile Induration; Steroids; Verapamil	2003
The management of Peyronie's disease. BJU international, 2004, Volume: 93, Issue:2 Topics: 4-Aminobenzoic Acid; Colchicine; Humans; Interferon alpha-2; Interferon-alpha; Lithotripsy; Male; Penile Induration; Penile Prosthesis; Penis; Recombinant Proteins; Tamoxifen; Verapamil; Vitamin E	2004
Current status and new developments in Peyronie's disease: medical, minimally invasive and surgical treatment options. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:6 Topics: 4-Aminobenzoic Acid; Colchicine; Collagenases; Drug Administration Routes; Humans; Interferon-alpha; Male; Minimally Invasive Surgical Procedures; Penile Implantation; Penile Induration; Penis; Pharmaceutical Preparations; PubMed; Radiotherapy; Verapamil; Vitamin E	2011
Inflammatory mechanisms and oxidative stress in Peyronie's disease: therapeutic "rationale" and related emerging treatment strategies. Inflammation & allergy drug targets, 2012, Volume: 11, Issue:1 Topics: Animals; Colchicine; Humans; Inflammation; Male; Oxidative Stress; Penile Induration; Penis; Reactive Oxygen Species; Treatment Outcome; Verapamil; Vitamin E	2012
[Review of Peyronie's disease]. Harefuah, 2012, Volume: 151, Issue:11 Topics: Colchicine; Humans; Injections, Intralesional; Male; Penile Induration; Tamoxifen; Verapamil; Vitamin E	2012
Minimally invasive treatment of Peyronie's disease: evidence-based progress. BJU international, 2014, Volume: 114, Issue:1 Topics: 4-Aminobenzoic Acid; Administration, Oral; Calcium Channel Blockers; Carnitine; Colchicine; Evidence-Based Medicine; Humans; Injections, Intralesional; Interferon-alpha; Iontophoresis; Lithotripsy; Male; Microbial Collagenase; Nicardipine; Penile Induration; Phosphodiesterase Inhibitors; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Verapamil; Vitamin E	2014

Trials

1 trial(s) available for verapamil and colchicine

Article	Year
Pharmacological therapy in patients diagnosed with Peyronie's disease. Journal of medicine and life, 2012, Jun-12, Volume: 5, Issue:2 Topics: Adult; Aged; Colchicine; Drug Therapy, Combination; Humans; Male; Middle Aged; Penile Induration; Verapamil; Vitamin E; Young Adult	2012

Other Studies

123 other study(ies) available for verapamil and colchicine

Article	Year
A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles. Analytical biochemistry, 1999, Mar-15, Volume: 268, Issue:2 Topics: Adenosine Triphosphate; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Membrane; Colchicine; Drug Resistance, Multiple; Fluoresceins; Humans; Kinetics; Methotrexate; Methylene Blue; Sodium-Potassium-Exchanging ATPase; Spectrometry, Fluorescence; Tumor Cells, Cultured; Vinblastine	1999
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical research, 2003, Volume: 20, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells. Bioorganic & medicinal chemistry, 2010, Apr-15, Volume: 18, Issue:8 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Malonates; Morpholines; Triterpenes	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Male; Melanoma; Models, Molecular; Paclitaxel; Prostatic Neoplasms; Structure-Activity Relationship; Tubulin Modulators	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents. Bioorganic & medicinal chemistry letters, 2016, 07-15, Volume: 26, Issue:14 Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Monocarboxylic Acid Transporters; Structure-Activity Relationship; Symporters	2016
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA). European journal of medicinal chemistry, 2018, Mar-25, Volume: 148 Topics: Alkynes; Animals; Anti-Bacterial Agents; Half-Life; Methicillin-Resistant Staphylococcus aureus; Mice; Microsomes, Liver; Staphylococcal Infections; Thiazoles	2018
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dictamnus; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Furans; Humans; MCF-7 Cells; Molecular Structure; Quinolines; Structure-Activity Relationship; Tubulin	2018
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities. Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17 Topics: Animals; Cell Proliferation; Chalcones; Humans; Male; Melanoma; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Prostatic Neoplasms; Protein Conformation; Tubulin; Tubulin Modulators; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2018
Bovine lens epithelium: a suitable model for studying growth control mechanisms. C6-substituted purines inhibit cell flattening and growth stimulation of G0 cells. Experimental cell research, 1979, Volume: 122, Issue:2 Topics: Animals; Calcium; Cattle; Cell Movement; Colchicine; Culture Techniques; Cytochalasin B; Dactinomycin; Epithelial Cells; Epithelium; Ethidium; Lens, Crystalline; Mitosis; Models, Biological; Purines; Verapamil	1979
Hyperreactive arterial endothelial cells in atherogenesis. Effect of smooth muscle relaxants. Advances in experimental medicine and biology, 1977, Volume: 82 Topics: Actomyosin; Animals; Aorta; Arteriosclerosis; Biological Transport; Carbamates; Carbon; Colchicine; Endothelium; Parasympatholytics; Phthalazines; Pyridazines; Pyridinolcarbamate; Rabbits; Verapamil; Vinblastine	1977
The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology, 1992, Volume: 102, Issue:3 Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Colchicine; Daunorubicin; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Ileum; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Membrane Glycoproteins; Microvilli; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Temperature; Verapamil	1992
Drugs affecting microtubule dynamics increase alpha-tubulin mRNA accumulation via transcription in Tetrahymena thermophila. Molecular and cellular biology, 1992, Volume: 12, Issue:4 Topics: Alkaloids; Animals; Colchicine; Cytochalasin B; Dinitrobenzenes; Dose-Response Relationship, Drug; Food Deprivation; Immunohistochemistry; Microtubules; Paclitaxel; RNA, Messenger; Sulfanilamides; Tetrahymena thermophila; Transcription, Genetic; Tubulin; Verapamil	1992
Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. Journal of cellular physiology, 1992, Volume: 152, Issue:1 Topics: Adrenal Glands; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Cyclic AMP; Cytotoxins; Female; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mutation; Ovary; Polymerase Chain Reaction; Precipitin Tests; Protein Kinases; Quinidine; RNA, Messenger; Steroids; Transcription, Genetic; Transfection; Verapamil	1992
Characterization of the azidopine and vinblastine binding site of P-glycoprotein. The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Cell Membrane; Colchicine; Cyanogen Bromide; Dihydropyridines; Drug Resistance; Humans; KB Cells; Kinetics; Membrane Glycoproteins; Molecular Weight; Peptide Fragments; Transfection; Trypsin; Verapamil; Vinblastine; Vincristine	1992
The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochemical and biophysical research communications, 1992, Nov-30, Volume: 189, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; Kinetics; Membrane Glycoproteins; Quinidine; Verapamil; Vinblastine	1992
Evidence that protein kinase-A, calcium-calmodulin kinase and cytoskeletal proteins are involved in osteoclast retraction induced by calcitonin. Experimental and molecular pathology, 1992, Volume: 57, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Resorption; Calcitonin; Cells, Cultured; Colchicine; Colforsin; Cytoskeletal Proteins; In Vitro Techniques; Isoquinolines; Neomycin; Osteoclasts; Phospholipases A; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Quinacrine; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Verapamil	1992
Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1990, Volume: 38, Issue:5 Topics: Alkalies; Animals; Benzopyrans; Cell Line; Colchicine; Cytosol; Dextrans; Drug Carriers; Drug Resistance; Fluorescent Dyes; Hydrogen-Ion Concentration; Microinjections; Verapamil; Vinblastine	1990
Characterisation of a mouse tumour cell line with in vitro derived resistance to verapamil. British journal of cancer, 1990, Volume: 61, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Colchicine; DNA, Neoplasm; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Membrane Glycoproteins; Mice; Tumor Cells, Cultured; Verapamil; Vincristine	1990
Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin). British journal of cancer, 1990, Volume: 62, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium-Binding Proteins; Carcinosarcoma; Cell Line; Colchicine; Cyclosporins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Gene Expression; Mammary Neoplasms, Animal; Membrane Glycoproteins; Mice; Neoplasm Proteins; Verapamil; Vincristine	1990
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro. Cancer research, 1990, Dec-01, Volume: 50, Issue:23 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Survival; Colchicine; Dipyridamole; Drug Resistance; Drug Synergism; Etoposide; Humans; In Vitro Techniques; Membrane Glycoproteins; Neoplasm Proteins; Verapamil; Vinblastine	1990
Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. Cancer research, 1991, Feb-01, Volume: 51, Issue:3 Topics: Carcinoma, Squamous Cell; Cell Membrane Permeability; Chromatography, Gel; Colchicine; Doxorubicin; Drug Resistance; Humans; Polyethylene Glycols; Rhodamine 123; Rhodamines; Stearic Acids; Tumor Cells, Cultured; Verapamil; Vinblastine	1991
Involvement of cell calcium and transmembrane potential in control of hepatocyte volume. Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:5 Topics: Animals; Calcium; Calmodulin; Colchicine; Culture Techniques; Cytochalasin B; Cytoskeleton; Dose-Response Relationship, Drug; Liver; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Microelectrodes; Osmolar Concentration; Osmotic Pressure; Promethazine; Trifluoperazine; Verapamil	1991
[Multidrug resistance in Entamoeba histolytica]. Archivos de investigacion medica, 1990, Volume: 21 Suppl 1 Topics: Animals; Colchicine; DNA, Protozoan; Drug Interactions; Drug Resistance; Emetine; Entamoeba histolytica; Gene Amplification; Nucleic Acid Hybridization; Verapamil	1990
Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin. Cancer research, 1990, Aug-15, Volume: 50, Issue:16 Topics: Animals; Cell Line; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Folic Acid Antagonists; Kinetics; Methotrexate; Ovary; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil	1990
Reversal of multi-drug resistance in human KB cell lines by structural analogs of verapamil. International journal of cancer, 1990, May-15, Volume: 45, Issue:5 Topics: Cell Survival; Colchicine; Doxorubicin; Drug Resistance; HeLa Cells; Humans; Isomerism; KB Cells; Structure-Activity Relationship; Tumor Stem Cell Assay; Verapamil	1990
Entamoeba histolytica: physiology of multidrug resistance. Experimental parasitology, 1990, Volume: 71, Issue:2 Topics: Animals; Colchicine; Cross Reactions; Dactinomycin; Daunorubicin; Drug Resistance; Emetine; Entamoeba histolytica; Verapamil	1990
Intracellular mechanisms of the effect of thromboxane A2 on water transport. Advances in prostaglandin, thromboxane, and leukotriene research, 1989, Volume: 19 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Body Water; Calcium; Cell Line; Colchicine; Kidney; Kinetics; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Trifluoperazine; Verapamil	1989
Elimination of permeability mutants from selections for drug resistance in mammalian cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:2 Topics: Alkaloids; Animals; Cell Line; Cell Membrane Permeability; Colchicine; Cricetinae; Drug Resistance; Griseofulvin; In Vitro Techniques; Microtubules; Paclitaxel; Selection, Genetic; Tubulin; Verapamil; Vinblastine	1989
Non-p-glycoprotein-mediated multidrug resistance in detransformed rat cells selected for resistance to methylglyoxal bis(guanylhydrazone). Cancer research, 1989, Nov-01, Volume: 49, Issue:21 Topics: Adult; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Brain; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Colchicine; Drug Resistance; Gene Amplification; Gene Expression; Humans; Kinetics; Membrane Glycoproteins; Mitoguazone; Rats; Verapamil	1989
Enhancement of cytogenetic and cytotoxic effects on multidrug-resistant (MDR) cells by a calcium antagonist (verapamil). Mutation research, 1989, Volume: 227, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Chromosomes; Colchicine; Drug Resistance; Drug Synergism; Verapamil	1989
Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells. Cancer treatment reports, 1986, Volume: 70, Issue:2 Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Nicotinic Acids; Nimodipine; Ovary; Paclitaxel; Pimozide; Verapamil	1986
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells. Cancer research, 1987, Oct-15, Volume: 47, Issue:20 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Banding; Chromosomes, Human, Pair 13; Colchicine; Dactinomycin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia; Membrane Glycoproteins; Molecular Weight; Podophyllotoxin; Teniposide; Tumor Cells, Cultured; Verapamil; Vinblastine; Vinca Alkaloids	1987
Role of calcium in the activation of neutrophils by leukocyte inhibitory factor (LIF). Lymphokine research, 1987,Fall, Volume: 6, Issue:4 Topics: Calcium; Cell Membrane; Colchicine; Fluorescent Dyes; Kinetics; Leukocyte Migration-Inhibitory Factors; Lymphokines; Neutrophils; Trifluoperazine; Verapamil	1987
Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells. Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7 Topics: Animals; Cell Line; Cell Survival; Colchicine; Cytochalasin B; Cytochalasin D; Cytochalasins; Daunorubicin; Drug Resistance; Humans; Leukemia; Leukemia P388; Leukemia, Myeloid, Acute; Mice; Verapamil; Vincristine	1986
Action of calcium antagonists on multidrug resistant cells. Specific cytotoxicity independent of increased cancer drug accumulation. Biochemical pharmacology, 1987, Jul-01, Volume: 36, Issue:13 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium; Calcium Channel Blockers; Cell Line; Cell Survival; Colchicine; Cricetinae; Daunorubicin; Drug Resistance; Humans; Kinetics; Mice; Nifedipine; Trifluoperazine; Verapamil; Vinblastine	1987
Verapamil hypersensitivity of vincristine resistant Chinese hamster ovary cell lines. Cell biology international reports, 1986, Volume: 10, Issue:5 Topics: Animals; Cell Line; Cell Survival; Colchicine; Doxorubicin; Drug Resistance; Kinetics; Verapamil; Vincristine	1986
Thrombin-induced shape changes of cultured endothelial cells: metabolic and functional observations. Thrombosis research, 1983, Oct-01, Volume: 32, Issue:1 Topics: Calcium; Cells, Cultured; Clot Retraction; Colchicine; Cytochalasins; Cytoskeleton; Endothelium; Humans; Microtubules; Nifedipine; Temperature; Thrombin; Umbilical Veins; Verapamil	1983
Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine. Molecular and cellular biology, 1994, Volume: 14, Issue:4 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport; Cell Survival; Chloroquine; CHO Cells; Colchicine; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Protozoan; Doxorubicin; Drug Resistance; Female; Gene Expression; Genes, Protozoan; Membrane Proteins; Oligonucleotides, Antisense; Oocytes; Plasmodium falciparum; Primaquine; Protozoan Proteins; Quinine; Restriction Mapping; Verapamil; Vinblastine; Xenopus laevis	1994
Cell-specific effects of RAS oncogene and protein kinase C agonist TPA on P-glycoprotein function. FEBS letters, 1995, Jul-17, Volume: 368, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Colchicine; Dogs; Drug Resistance, Multiple; Gene Expression Regulation; Genes, ras; Genetic Vectors; Humans; Protein Kinase C; Rats; Retroviridae; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Verapamil	1995
Expression of multidrug resistance in response to differentiation in the K562 human leukaemia cell line. Biochemical pharmacology, 1995, Aug-08, Volume: 50, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Butyrates; Butyric Acid; Cell Differentiation; Cell Survival; Colchicine; Drug Resistance, Multiple; Epirubicin; Humans; Leukemia; Phenotype; Rhodamine 123; Rhodamines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil	1995
Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities. The Journal of biological chemistry, 1995, Sep-15, Volume: 270, Issue:37 Topics: 3T3 Cells; Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Ca(2+) Mg(2+)-ATPase; Cell Line; Chromatography, Affinity; Colchicine; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Humans; Kidney; Kinetics; Mice; Mutagenesis, Site-Directed; Nickel; Point Mutation; Recombinant Proteins; Transfection; Verapamil; Vinblastine	1995
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein. Archives of biochemistry and biophysics, 1995, Jan-10, Volume: 316, Issue:1 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Dihydropyridines; Escherichia coli; Lipids; Liver; Proteolipids; Sheep; Verapamil; Vinblastine	1995
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. Cancer research, 1995, Mar-01, Volume: 55, Issue:5 Topics: 3T3 Cells; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Death; Cell Survival; Colchicine; Cyclosporine; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Membrane Glycoproteins; Mice; Phenotype; Point Mutation; Quinidine; Transfection; Verapamil	1995
Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein. The Journal of biological chemistry, 1993, Nov-15, Volume: 268, Issue:32 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Proteolipids; Verapamil; Vinblastine	1993
Absence of cooperativity for MgATP and verapamil effects on the ATPase activity of P-glycoprotein containing membrane vesicles. Biochemical and biophysical research communications, 1993, Nov-15, Volume: 196, Issue:3 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cell Line; Cell Membrane; Cell Survival; Colchicine; Cricetinae; Cricetulus; Dactinomycin; Drug Interactions; Drug Resistance; Electrophoresis, Disc; Kinetics; Lung; Membrane Glycoproteins; Membrane Proteins; Ouabain; Sodium Azide; Verapamil; Vincristine	1993
Effect of multidrug-resistant P-glycoprotein gene expression on chloroaluminum tetrasulfonate phthalocyanine concentration. Lasers in surgery and medicine, 1993, Volume: 13, Issue:5 Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Daunorubicin; Drug Resistance; Gene Expression; Indoles; Lasers; Membrane Glycoproteins; Mice; Organometallic Compounds; Radiation-Sensitizing Agents; Transfection; Verapamil	1993
Drugs transported by P-glycoprotein inhibit a 40 pS outwardly rectifying chloride channel. Biochemical and biophysical research communications, 1994, Apr-15, Volume: 200, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Membrane; Chloride Channels; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Drug Resistance; Ion Channel Gating; Membrane Glycoproteins; Membrane Potentials; Verapamil; Vinblastine	1994
Reversal of multidrug resistance by RU 486. Cancer research, 1994, Jun-15, Volume: 54, Issue:12 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Daunorubicin; Dexamethasone; Drug Resistance; Female; Kinetics; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mifepristone; Phenotype; Puromycin; Structure-Activity Relationship; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Verapamil	1994
Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Molecular pharmacology, 1994, Volume: 45, Issue:6 Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Carrier Proteins; Colchicine; Drug Resistance; Humans; Membrane Glycoproteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vincristine	1994
Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells. Journal of cancer research and clinical oncology, 1994, Volume: 120, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Clone Cells; Colchicine; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Novobiocin; Phenotype; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine	1994
Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells. Journal of the National Cancer Institute, 1993, Jan-06, Volume: 85, Issue:1 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Fusion; CHO Cells; Colchicine; Colony-Forming Units Assay; Cricetinae; Doxorubicin; Drug Resistance; Genes, Dominant; Glutathione Transferase; Hybrid Cells; Membrane Glycoproteins; Phenotype; Radiation Genetics; Verapamil; Vincristine	1993
In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour. Journal of cancer research and clinical oncology, 1993, Volume: 119, Issue:10 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colchicine; Colonic Neoplasms; Cyclosporine; Drug Resistance; Drug Synergism; Male; Membrane Glycoproteins; Neoplasm Proteins; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Verapamil	1993
Relationship between multidrug resistance, hypersensitivity to resistance modifiers and cell volume in Chinese hamster ovary cells. Cell biology international, 1993, Volume: 17, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Carrier Proteins; Cell Line; Cell Size; CHO Cells; Colchicine; Cricetinae; Doxorubicin; Drug Hypersensitivity; Drug Resistance; Membrane Glycoproteins; Molecular Sequence Data; Verapamil; Vincristine	1993
Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Molecular endocrinology (Baltimore, Md.), 1993, Volume: 7, Issue:7 Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Southern; Carrier Proteins; Colchicine; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance; Flow Cytometry; Gene Amplification; Gene Expression Regulation, Neoplastic; Genetic Variation; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phenotype; Puromycin; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Verapamil	1993
Gain and loss of hypersensitivity to resistance modifiers in multidrug resistant Chinese hamster ovary cells. Cancer letters, 1995, Nov-27, Volume: 98, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; CHO Cells; Colchicine; Cricetinae; Culture Media; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Species Specificity; Verapamil	1995
Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells. Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Survival; Cisplatin; Colchicine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Lymphoma; Methionine Sulfoximine; Mitosis; Ovarian Neoplasms; Paclitaxel; Rats; Tumor Cells, Cultured; Verapamil; Vinca Alkaloids	1996
Degradation of radioiodinated B cell monoclonal antibodies: inhibition via a FCgamma-receptor-II-mediated mechanism and by drugs. Cancer immunology, immunotherapy : CII, 1996, Volume: 42, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; B-Lymphocytes; Biological Transport; Burkitt Lymphoma; Calcium Channel Blockers; Cell Adhesion Molecules; Chloroquine; Colchicine; Etoposide; Humans; Immunoglobulin Isotypes; Immunotoxins; Iodine Radioisotopes; Lectins; Leukemia, B-Cell; Mice; Monensin; Paclitaxel; Radioimmunotherapy; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 2; Verapamil; Vinblastine; Vincristine	1996
BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Molecular pharmacology, 1996, Volume: 50, Issue:3 Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Cell Survival; CHO Cells; Colchicine; Cricetinae; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Kinetics; Lymphoma; Morpholines; Peptide Mapping; Protein Binding; Triamterene; Tumor Cells, Cultured; Verapamil; Vinblastine	1996
Cross-resistance to cis-diamminedichloroplatinum(II) of a multidrug-resistant lymphoma cell line associated with decreased drug accumulation and enhanced DNA repair. European journal of pharmacology, 1996, Jun-03, Volume: 305, Issue:1-3 Topics: Antineoplastic Agents; Aphidicolin; Cell Survival; Cisplatin; Colchicine; DNA Adducts; DNA Repair; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Gene Expression; Genes, MDR; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Mitomycin; Polymerase Chain Reaction; Puromycin; Spectrophotometry, Atomic; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Verapamil; Vincristine	1996
Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine. Journal of neurochemistry, 1996, Volume: 67, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Colchicine; Cyclosporins; Male; Organ Specificity; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Sucrose; Tissue Distribution; Tritium; Verapamil; Vinblastine	1996
Overexpression of P-glycoprotein in heat- and/or drug-resistant hepatoma variants. Cytotechnology, 1996, Volume: 19, Issue:3 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clone Cells; Colchicine; Dactinomycin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hot Temperature; HSP70 Heat-Shock Proteins; Liver Neoplasms, Experimental; Neoplasm Proteins; Puromycin; Rats; RNA, Messenger; RNA, Neoplasm; Selection, Genetic; Stress, Physiological; Tumor Cells, Cultured; Verapamil; Vinblastine	1996
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular biology of the cell, 1996, Volume: 7, Issue:10 Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine	1996
Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates. The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44 Topics: Adenosine Triphosphatases; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Colchicine; Cross-Linking Reagents; Cysteine; DNA, Complementary; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidants; Peptide Fragments; Point Mutation; Recombinant Proteins; Transfection; Verapamil; Vinblastine	1996
Ureteral cell cultures II: Collagen production and response to pharmacologic agents. The Journal of urology, 1996, Volume: 156, Issue:6 Topics: Cell Division; Cells, Cultured; Colchicine; Collagen; Epithelial Cells; Epithelium; Fibroblasts; Humans; Hydrocortisone; Muscle, Smooth; Penicillamine; Ureter; Verapamil; Vitamin A	1996
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. Human gene therapy, 1996, Nov-10, Volume: 7, Issue:17 Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Cells, Cultured; Colchicine; Cyclosporins; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fibroblasts; Gaucher Disease; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Glucosylceramidase; Humans; Mice; Mutagenesis, Insertional; Retroviridae; Transfection; Verapamil	1996
Role of P-170 glycoprotein in colchicine brain uptake. Journal of neuroscience research, 1997, Jul-01, Volume: 49, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Colchicine; Endothelium, Vascular; Injections, Intravenous; Male; Perfusion; Rats; Verapamil	1997
Drug-stimulated ATPase activity of human P-glycoprotein requires movement between transmembrane segments 6 and 12. The Journal of biological chemistry, 1997, Aug-22, Volume: 272, Issue:34 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Humans; Membrane Glycoproteins; Movement; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Transfection; Verapamil; Vinblastine	1997
Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. The Journal of biological chemistry, 1997, Aug-22, Volume: 272, Issue:34 Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Membrane; Colchicine; Drug Resistance, Multiple; Humans; Kinetics; Mice; Recombinant Proteins; Verapamil; Vinblastine	1997
Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity. Biochimica et biophysica acta, 1997, Aug-22, Volume: 1361, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Enzyme Activation; Gramicidin; Kinetics; Microsomes; Progesterone; Vanadates; Verapamil; Vinblastine	1997
Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate. The Journal of biological chemistry, 1997, Dec-19, Volume: 272, Issue:51 Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Colchicine; Cysteine; Enzyme Inhibitors; Humans; Mutagenesis, Site-Directed; Sulfhydryl Compounds; Verapamil; Vinblastine	1997
The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Colchicine; Cyclosporine; Dipyridamole; Lipids; Rats; Solubility; Verapamil; Zidovudine	1998
P-glycoprotein is more efficient at limiting uptake than inducing efflux of colchicine and vinblastine in HL-60 cells. Pharmaceutical research, 1998, Volume: 15, Issue:5 Topics: Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Colchicine; Gout Suppressants; HL-60 Cells; Humans; Verapamil; Vinblastine	1998
Mutational analysis of human P-glycoprotein. Methods in enzymology, 1998, Volume: 292 Topics: Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ca(2+) Mg(2+)-ATPase; Cell Line; Cell Survival; Cloning, Molecular; Colchicine; DNA Mutational Analysis; Escherichia coli; Humans; Indicators and Reagents; Kinetics; Mutagenesis, Site-Directed; Pichia; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Spodoptera; Transfection; Verapamil; Vinblastine	1998
Purification and reconstitution of human P-glycoprotein. Methods in enzymology, 1998, Volume: 292 Topics: 3T3 Cells; Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, Affinity; Chromatography, Ion Exchange; Clone Cells; Colchicine; Cricetinae; Daunorubicin; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Humans; Indicators and Reagents; KB Cells; Kinetics; Liposomes; Mice; Proteolipids; Recombinant Proteins; Solubility; Transfection; Verapamil; Vinblastine	1998
Swelling-activated chloride currents in a drug-sensitive cell line and a P glycoprotein-expressing derivative are underlied by channels with the same pharmacological properties. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1998, Volume: 8, Issue:5 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Size; Chloride Channels; Colchicine; Cytochalasin D; Cytoskeleton; Electrophysiology; Etoposide; Humans; Hypertonic Solutions; Hypotonic Solutions; Meglumine; Nitrobenzenes; Tumor Cells, Cultured; Verapamil; Vinblastine	1998
Does the lack of the P-glycoprotein efflux pump in neutrophils explain the efficacy of colchicine in familial Mediterranean fever and other inflammatory diseases? Medical hypotheses, 1998, Volume: 51, Issue:5 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 7; Colchicine; Familial Mediterranean Fever; Gout Suppressants; Humans; In Vitro Techniques; Inflammation; Leukocytes; Neutrophils; Rhodamines; Verapamil	1998
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin. Cancer biochemistry biophysics, 1998, Volume: 16, Issue:4 Topics: Adenocarcinoma; Cell Survival; Colchicine; Cyclosporine; Cytochalasin B; Cytochalasin D; Cytoskeleton; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Neoplasm Proteins; Paclitaxel; Tubulin; Tumor Cells, Cultured; Verapamil; Vincristine	1998
Coordinated regulation of P-glycoprotein activity and cytochrome P-4501A induction in sublines of rat hepatoma McA RH7777 cells with different levels of colchicine resistance. Membrane & cell biology, 1998, Volume: 12, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzopyrenes; Colchicine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Liver Neoplasms, Experimental; Oxazines; Rats; Tumor Cells, Cultured; Verapamil	1998
ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation. Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:7 Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cerebellum; Colchicine; Cyclosporine; Cysteine Proteinase Inhibitors; Deoxyglucose; Dizocilpine Maleate; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Glutathione; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microtubules; Neurons; Neuroprotective Agents; Nitroso Compounds; Nocodazole; Oligopeptides; Paclitaxel; Potassium; Protein Biosynthesis; S-Nitrosoglutathione; Tacrolimus; Verapamil	1999
Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane. The Journal of biological chemistry, 1999, Dec-10, Volume: 274, Issue:50 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Colchicine; Cysteine; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Verapamil; Vinblastine	1999
The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis. The Journal of biological chemistry, 2000, Feb-25, Volume: 275, Issue:8 Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; Cell Line; Colchicine; Cross-Linking Reagents; Cyclosporine; Cysteine; Cytoplasm; Disulfides; Enzyme Inhibitors; Humans; Membrane Proteins; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Temperature; Verapamil; Vinblastine	2000
Multidrug resistance increment in a human colon carcinoma cell line by colchicine. Journal of physiology and biochemistry, 2000, Volume: 56, Issue:1 Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colchicine; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mitomycin; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine	2000
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein. International journal of oncology, 2000, Volume: 17, Issue:3 Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine	2000
Inhibition of Peyronie's plaque fibroblast proliferation by biologic agents. International journal of impotence research, 2000, Volume: 12 Suppl 3 Topics: Alprostadil; Antiviral Agents; Calcium Channel Blockers; Cell Separation; Cells, Cultured; Colchicine; Fibrinolytic Agents; Fibroblasts; Humans; Interferon-alpha; Male; Penile Induration; Verapamil	2000
Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane. The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50 Topics: Adenosine Triphosphatases; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Calcium Channel Blockers; Colchicine; Cross-Linking Reagents; Cysteine; Humans; Immunoblotting; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Verapamil; Vinblastine	2000
Structure-activity relationship of P-glycoprotein substrates and modifiers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 12, Issue:1 Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine	2000
Effect of P-glycoprotein on flavopiridol sensitivity. British journal of cancer, 2001, May-18, Volume: 84, Issue:10 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; CHO Cells; Cisplatin; Colchicine; Colony-Forming Units Assay; Cricetinae; Drug Resistance, Multiple; Flavonoids; Paclitaxel; Piperidines; Quinidine; Verapamil	2001
Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer research, 2001, May-15, Volume: 61, Issue:10 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Colchicine; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Genes, MDR; Humans; Inhibitory Concentration 50; KB Cells; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tropanes; Tumor Cells, Cultured; Verapamil; Vinblastine	2001
Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice. Pharmaceutical research, 2001, Volume: 18, Issue:2 Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Colchicine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Isoquinolines; Male; Mice; Perfusion; Tetrahydroisoquinolines; Time Factors; Verapamil; Vinblastine	2001
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule. American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:1 Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin	2002
Selective modulation of P-glycoprotein-mediated drug resistance. British journal of cancer, 2001, Dec-14, Volume: 85, Issue:12 Topics: Allosteric Regulation; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Cell Division; Cell Membrane; Chlorpromazine; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Membrane Lipids; Neoplasm Proteins; Phospholipids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temperature; Tumor Cells, Cultured; Verapamil; Vinblastine	2001
Verapamil sensitisation to alkaloids on colchicine-selected human colon adenocarcinoma cells. Journal of physiology and biochemistry, 2001, Volume: 57, Issue:4 Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Survival; Colchicine; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine	2001
Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites. The Journal of biological chemistry, 2003, Dec-12, Volume: 278, Issue:50 Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Calcium Channel Blockers; Cell Line; Colchicine; Cysteine; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Fluoresceins; Fluorescent Dyes; Histidine; Humans; Mesylates; Models, Biological; Models, Chemical; Mutation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rhodamines; Verapamil	2003
Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein. The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Catalysis; CHO Cells; Colchicine; Cricetinae; Dose-Response Relationship, Drug; Entropy; Humans; Hydrolysis; Kinetics; Lipids; Models, Biological; Olive Oil; Plant Oils; Protein Conformation; Saccharomyces cerevisiae; Temperature; Thermodynamics; Time Factors; Verapamil	2003
In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier. Pharmaceutical research, 2004, Volume: 21, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Cyclosporins; Dexamethasone; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Progesterone; Quinidine; Verapamil; Vinblastine	2004
The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium. Biochemistry, 2004, Sep-28, Volume: 43, Issue:38 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Buffers; Cell Line; Colchicine; Cyclosporine; Cysteine; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Hydrolysis; Isoleucine; Mesylates; Mutation; Rhodamines; Verapamil; Water	2004
Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier. BMJ (Clinical research ed.), 2005, Sep-17, Volume: 331, Issue:7517 Topics: Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Female; Humans; Quadriplegia; Verapamil	2005
Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket. The Biochemical journal, 2006, Jun-15, Volume: 396, Issue:3 Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Colchicine; Cricetinae; Cyclosporine; Demecolcine; Disulfides; Dithiothreitol; Fluoresceins; Flupenthixol; Humans; Mesylates; Point Mutation; Protein Structure, Tertiary; Verapamil; Vinblastine	2006
Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:10 Topics: Adenosine Triphosphatases; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Cell Membrane; Colchicine; Cyclosporine; Dammaranes; Daunorubicin; Drug Resistance, Neoplasm; Ginsenosides; Humans; Hydrolysis; KB Cells; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship; Triterpenes; Verapamil	2007
Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. Pharmaceutical research, 2009, Volume: 26, Issue:4 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Caco-2 Cells; Cell Polarity; Citrus paradisi; Colchicine; Dose-Response Relationship, Drug; Flavanones; Food-Drug Interactions; Fruit; Furocoumarins; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Permeability; Quinidine; Rats; Rats, Wistar; Risk Assessment; Time Factors; Tubulin Modulators; Verapamil	2009
Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain. Biochemical pharmacology, 2009, Oct-15, Volume: 78, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillaries; Colchicine; Dose-Response Relationship, Drug; Infusions, Subcutaneous; Inulin; Least-Squares Analysis; Linear Models; Loperamide; Mice; Mice, Inbred Strains; Mice, Knockout; Microdissection; Perfusion; Quinidine; Regional Blood Flow; Substrate Specificity; Verapamil	2009
Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:10 Topics: Acridines; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Colchicine; Drug Interactions; Epithelium; Food-Drug Interactions; Humans; Ileum; Indoles; Intestinal Absorption; Intestine, Small; Jejunum; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxotremorine; p-Aminohippuric Acid; Permeability; Rats; Rats, Wistar; Tetrahydroisoquinolines; Verapamil	2009
Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions. Nutrition and cancer, 2011, Volume: 63, Issue:3 Topics: Adenosine Triphosphatases; Analysis of Variance; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Survival; Colchicine; Daunorubicin; Drug Resistance, Neoplasm; Flavonoids; Herb-Drug Interactions; Humans; Verapamil; Vinblastine	2011
Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells. Molecular pharmaceutics, 2011, Jun-06, Volume: 8, Issue:3 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Colchicine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; HT29 Cells; Humans; Inhibitory Concentration 50; Mutagenesis, Site-Directed; Polyethylene Glycols; Verapamil	2011
Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen. PloS one, 2012, Volume: 7, Issue:10 Topics: Algorithms; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cluster Analysis; Colchicine; Computational Biology; Cyclin-Dependent Kinases; Dasatinib; Databases, Genetic; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Neoplasms; Oligonucleotide Array Sequence Analysis; Paclitaxel; Pimozide; Purines; Pyrimidines; Terfenadine; Thiazoles; Tubulin Modulators; Verapamil	2012
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO Biochemical and biophysical research communications, 2022, 06-11, Volume: 608 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Doxorubicin; Drug Collateral Sensitivity; Drug Resistance; Verapamil	2022