verapamil has been researched along with cimetidine in 105 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (20.95) | 18.7374 |
| 1990's | 17 (16.19) | 18.2507 |
| 2000's | 28 (26.67) | 29.6817 |
| 2010's | 34 (32.38) | 24.3611 |
| 2020's | 4 (3.81) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
| Chieli, E; Romiti, N; Tramonti, G | 1 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Engel, K; Wang, J | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Pratim Roy, P; Roy, K | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Avdeef, A; Tam, KY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E | 1 |
| Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW | 1 |
| Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E | 1 |
| Wang, J | 1 |
| Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW | 1 |
| Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Bertaccini, G; Coruzzi, G; Vitali, T | 1 |
| Brandes, LJ; LaBella, FS | 1 |
| Haseley, TS; Hosford, M; Lesniak, ME; McKinney, TD; Scheller, MB | 1 |
| deLeon, C; McGuire, WL; Speeg, KV | 1 |
| Bassett, AL; Cameron, JS; Katz, D; Shin, GS; Swigart, CR | 1 |
| Mutafova-Yambolieva, V; Staneva-Stoytcheva, D; Todorov, S; Vassilev, P | 1 |
| Nishat, TA | 1 |
| Rahwan, RG; Wong, WS | 2 |
| Eichelbaum, M; Fischer, C; Gumulka, S; Klotz, U; Kroemer, HK; Mikus, G | 1 |
| Banerjee, RK; Bhattacharjee, M; Bose, AK | 1 |
| Kanaide, H; Kobayashi, S; Kuga, T; Matsumoto, T; Nakamura, M; Nishimura, J | 1 |
| Hasegawa, J; Hirai, S; Hisatome, I; Kotake, H; Mashiba, H | 1 |
| Lui, CY; McCall, D | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Yamagishi, F | 1 |
| Birkett, DJ; Matthews, AP; McManus, ME; Meller, D; Miners, JO; Robson, RA; Stupans, I | 1 |
| Barman, SA; Olson, MD; Saari, JT | 1 |
| Meijer, S; Mulder, NH; Offerman, JJ; Schraffordt Koops, HS; Sleijfer, DT; van der Hem, GK; Verweij, M | 1 |
| Darawshi, A; Landau, E; Reisin, LH | 1 |
| Abman, SH; Accurso, FJ; Ward, RM; Wilkening, RB | 1 |
| Lillywhite, KJ; Miners, JO; Wing, LM | 1 |
| Dukes, GE; Loi, CM; Peat, MA; Rollins, DE | 1 |
| Abernethy, DR; Schwartz, JB; Todd, EL | 1 |
| Dorrell, SG; Merrill, GF; Tozzi, CA | 1 |
| Kolts, BE; Langfitt, M | 1 |
| Bertaccini, G; Coruzzi, G; Fesani, F; Medici, D; Poli, E | 1 |
| Baskin, EP; Winquist, RJ | 1 |
| Benyunes, MC; Bjornsson, TD; Pritchett, EL; Shand, DG; Smith, MS | 1 |
| Bowman, FO; Levi, R; Malm, JR; Rosen, MR | 1 |
| Bai, SA; Johnson, LM; Lankford, SM | 1 |
| Anand, BS; Goodgame, R; Graham, DY | 1 |
| Brown, CD; Dudley, AJ | 1 |
| Adam, U; Drewelow, B; Fischer, U; Nitschke, FP; Rohde, B; Stange, J; Wacke, R | 1 |
| Crespi, CL; Fox, L; Hu, M; Steimel, DT; Stocker, P | 1 |
| Bittinger, F; Brockerhoff, P; Deutsch, C; Kilbinger, H; Kirkpatrick, CJ; Roth, E; Wessler, I | 1 |
| O'Donnell, MJ; Rheault, MR | 1 |
| Dohgu, S; Higuchi, S; Katamine, S; Kataoka, Y; Naito, M; Niwa, M; Sawada, Y; Shirabe, S; Takata, F; Tsuruo, T; Yamauchi, A | 1 |
| Atwell, R; Brown, L; Campbell, F; Fenning, A; Hoey, A | 1 |
| Sugawara, K; Tateishi, T; Uno, T; Yasui-Furukori, N | 1 |
| Crassaris, L; Giala, M; Mironidou, M; Pangalis, A; Papadakis, E; Paradelis, AG | 1 |
| Chen, Y; Du, L; Hu, J; Sun, H; Wai, Z; Wang, X; Xing, D | 1 |
| Bernkop-Schnürch, A; Hombach, J; Palmberger, TF | 1 |
| Hayashi, M; Kishimoto, H; Takizawa, Y; Tomita, M | 1 |
| Davey, AK; Hong, T; Jin, Y; Jiping, W; Lei, C; Qian, W; Ruijuan, X; Xuefen, Y; Xueying, Z; Yanxiao, C | 1 |
| Choudhury, A; Mandade, RJ; Sakarkar, DM; Sreenivas, SA | 1 |
| Hamman, JH; Tarirai, C; Viljoen, AM | 1 |
| Kaddoumi, A; Mohamed, LA | 1 |
| Chen, DP; Diao, YP; Lin, Y; Yao, QY; Ye, DM | 1 |
| Jung, JA; Parvez, MM; Shin, HJ; Shin, JG | 1 |
| Cho, HS; Jung, CR; Kang, HM; Lim, JH; Noh, KH; Park, D; Susztak, K | 1 |
| Bader, K; Ebner, T; Fromm, MF; Giessmann, T; Hauel, E; Hohl, K; Ishiguro, N; Jambrecina, A; Mikus, G; Müller, F; Schmidt-Gerets, S; Sharma, A; Stopfer, P; Taub, ME; Wiebe, ST | 1 |
| Deutsch, B; Fromm, MF; Gessner, A; Hohl, K; Keller, S; Müller, F; Schmidt-Gerets, S; Schuler-Metz, A; Stopfer, P | 1 |
4 review(s) available for verapamil and cimetidine
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Topics: Animals; Biogenic Amines; Humans; Plasma Membrane Neurotransmitter Transport Proteins; Xenobiotics | 2016 |
5 trial(s) available for verapamil and cimetidine
| Article | Year |
|---|---|
The influence of cimetidine on the pharmacokinetics of the enantiomers of verapamil in the dog during multiple oral dosing.
Topics: Administration, Oral; Animals; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Injections, Intravenous; Protein Binding; Spectrometry, Fluorescence; Stereoisomerism; Verapamil | 1995 |
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.
Topics: Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cimetidine; Drug Interactions; Half-Life; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Probenecid; Terfenadine; Uricosuric Agents; Verapamil | 2005 |
Pharmacological effects of aqueous-ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion.
Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Carbachol; Cimetidine; Disease Models, Animal; Gastric Acidity Determination; Gastric Juice; Hibiscus; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Stomach Ulcer; Verapamil | 2011 |
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Topics: Area Under Curve; Cimetidine; Drug Interactions; Humans; Male; Probenecid; Rifampin; Verapamil | 2020 |
N
Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Membrane Transport Proteins; Probenecid; Rifampin; Verapamil | 2023 |
96 other study(ies) available for verapamil and cimetidine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Cloning and functional expression of a human liver organic cation transporter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis | 1997 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cell Line, Transformed; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Kidney Tubules, Proximal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Cation Transport Proteins; Tyramine | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies | 2014 |
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins | 2014 |
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship | 2014 |
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2015 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship | 2016 |
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2016 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine | 2019 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate | 2022 |
Effect of histamine and related compounds on the papillary muscle of the guinea pig.
Topics: Animals; Chlorpheniramine; Cimetidine; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Metiamide; Myocardial Contraction; Papillary Muscles; Pyrilamine; Structure-Activity Relationship; Verapamil | 1978 |
Histamine and calcium are independently regulated intracellular mediators of lymphocyte mitogenesis.
Topics: Animals; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cerebral Cortex; Cimetidine; Concanavalin A; DNA Replication; Histamine; Histamine Antagonists; Kinetics; Lymphocytes; Mice; Mice, Inbred BALB C; Phenyl Ethers; Pyrilamine; Rats; Receptors, Histamine H1; Receptors, Nicotinic; Spleen; Verapamil | 1992 |
Basolateral transport of tetraethylammonium by a clone of LLC-PK1 cells.
Topics: Animals; Basement Membrane; Biological Transport, Active; Cimetidine; Clone Cells; Kidney; Kinetics; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1992 |
Uptake of the noncytotoxic transport probe procainamide in the Chinese hamster ovary model of multidrug resistance.
Topics: Animals; Azides; Calcium Channel Blockers; CHO Cells; Cimetidine; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Procainamide; Solubility; Temperature; Tetraethylammonium Compounds; Verapamil | 1992 |
Enhanced susceptibility to histamine-induced cardiac arrhythmias in spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cimetidine; Disease Susceptibility; Drug Interactions; Histamine; In Vitro Techniques; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Species Specificity; Verapamil | 1990 |
Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.
Topics: Animals; Calcium; Cimetidine; Dimaprit; Diphenhydramine; Electric Stimulation; Histamine; In Vitro Techniques; Male; Muscle Contraction; Rats; Receptors, Histamine H1; Receptors, Histamine H2; Thiazoles; Thiourea; Vas Deferens; Verapamil | 1991 |
A comparative study of the effects of verapamil and cimetidine on isolated rat stomach strip.
Topics: Acetylcholine; Animals; Cimetidine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptic Ulcer; Rats; Stomach; Verapamil | 1990 |
Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene--I. Effect on cold/restraint stress-induced ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cold Temperature; Dose-Response Relationship, Drug; Gastric Mucosa; Indenes; Male; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Physiological; Verapamil | 1990 |
Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene--II. Effects on acid secretion and gastric emptying in rats.
Topics: Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid; Gastric Emptying; Indenes; Male; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.
Topics: Administration, Oral; Adult; Biological Availability; Blood Pressure; Cimetidine; Drug Interactions; Gas Chromatography-Mass Spectrometry; Humans; Male; Stereoisomerism; Verapamil | 1990 |
Histamine H2-receptor mediated stimulation of gastric acid secretion by mercaptomethylimidazole.
Topics: Animals; Cimetidine; Gastric Acid; Male; Methimazole; Mice; Mice, Inbred BALB C; Nifedipine; Omeprazole; Parietal Cells, Gastric; Potassium; Proton-Translocating ATPases; Pylorus; Receptors, Histamine H2; Sodium; Verapamil | 1989 |
Histamine-induced calcium transients in vascular smooth muscle cells: effects of verapamil and diltiazem.
Topics: Aminoquinolines; Animals; Aorta; Calcium; Cell Fractionation; Cells, Cultured; Centrifugation, Density Gradient; Cimetidine; Cytosol; Diltiazem; Fluorescent Dyes; Histamine; Kinetics; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Pyrilamine; Rats; Rats, Inbred Strains; Sarcolemma; Swine; Verapamil | 1989 |
Inotropic effect of thyrotropin-releasing hormone on the guinea pig myocardium.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Kinetics; Manganese; Metoclopramide; Myocardial Contraction; Norepinephrine; Phentolamine; Potassium; Stimulation, Chemical; Thyrotropin-Releasing Hormone; Verapamil | 1988 |
The effects of histamine on contraction frequency, sodium influx, and cyclic AMP in cultured rat heart cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Cimetidine; Cyclic AMP; Diphenhydramine; Heart; Histamine; Imines; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1986 |
Effects of forskolin on pancreatic exocrine secretion and cyclic nucleotide concentrations of the dog pancreas.
Topics: Animals; Atropine; Cimetidine; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Female; Male; Nucleotides, Cyclic; Pancreatic Juice; Phentolamine; Propranolol; Sulpiride; Verapamil | 1987 |
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies.
Topics: Adult; Benzoflavones; Caffeine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Humans; Immunologic Techniques; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Verapamil | 1988 |
Histamine induced alteration of calcium binding to microvascular endothelium as indicated by use of ionic lanthanum.
Topics: Animals; Binding Sites; Calcium; Capillary Permeability; Cimetidine; Diphenhydramine; Endothelium, Vascular; Female; Histamine; In Vitro Techniques; Lanthanum; Male; Microcirculation; Microscopy, Electron; Rabbits; Verapamil | 1987 |
The protective potential of the combination of verapamil and cimetidine on cisplatin-induced nephrotoxicity in man.
Topics: Adult; Cimetidine; Cisplatin; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Kidney; Renal Circulation; Verapamil | 1987 |
[A-V block secondary to cimetidine-verapamil interaction].
Topics: Adult; Atrial Fibrillation; Cimetidine; Drug Interactions; Heart Block; Humans; Male; Verapamil | 1987 |
Adaptation of fetal pulmonary blood flow to local infusion of tolazoline.
Topics: Animals; Blood Pressure; Cimetidine; Diphenhydramine; Female; Fetus; Heart Rate; Phentolamine; Pregnancy; Pulmonary Circulation; Sheep; Tolazoline; Verapamil | 1986 |
Verapamil disposition--effects of sulphinpyrazone and cimetidine.
Topics: Adult; Cimetidine; Drug Interactions; Female; Humans; Male; Sex Factors; Sulfinpyrazone; Verapamil | 1985 |
Effect of cimetidine on verapamil disposition.
Topics: Adult; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Indocyanine Green; Kinetics; Liver; Male; Regional Blood Flow; Verapamil | 1985 |
Lack of interaction between verapamil and cimetidine.
Topics: Administration, Oral; Adult; Biological Availability; Blood Proteins; Chromatography, Gas; Cimetidine; Drug Administration Schedule; Drug Interactions; Electrocardiography; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Random Allocation; Verapamil | 1985 |
Evidence of histamine-induced myocardial ischaemia: reversal by chlorpheniramine and potentiation by atherosclerosis.
Topics: Animals; Arteriosclerosis; Chlorpheniramine; Cimetidine; Coronary Circulation; Coronary Disease; Coronary Vessels; Histamine; Male; Rabbits; Verapamil | 1985 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil | 1984 |
Negative inotropic effect of some H2-receptor antagonists on the isolated human atria.
Topics: Calcium; Cimetidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Atria; Histamine H2 Antagonists; Humans; Imidazoles; Myocardial Contraction; Pyrimidinones; Verapamil | 1983 |
Calcium channels resistant to organic calcium entry blockers in a rabbit vein.
Topics: Animals; Benzazepines; Calcium; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Face; Histamine; Ion Channels; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phentolamine; Propranolol; Rabbits; Temperature; Veins; Verapamil | 1983 |
Influence of cimetidine on verapamil kinetics and dynamics.
Topics: Administration, Oral; Adult; Biological Availability; Blood Pressure; Chromatography, High Pressure Liquid; Cimetidine; Double-Blind Method; Drug Interactions; Electrocardiography; Humans; Injections, Intravenous; Kinetics; Male; Random Allocation; Time Factors; Verapamil | 1984 |
The arrhythmogenic actions of histamine on human atrial fibers.
Topics: Action Potentials; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Child, Preschool; Cimetidine; Epinephrine; Heart Atria; Histamine; Humans; Infant; Middle Aged; Myocardial Contraction; Propranolol; Verapamil | 1981 |
Pancreatic secretion in man: effect of fasting, drugs, pancreatic enzymes, and somatostatin.
Topics: Acetazolamide; Adult; Cimetidine; Cutaneous Fistula; Fasting; Humans; Lipase; Male; Octreotide; Pancreas; Pancreatic Fistula; Pancreatin; Propantheline; Somatostatin; Verapamil | 1994 |
Mediation of cimetidine secretion by P-glycoprotein and a novel H(+)-coupled mechanism in cultured renal epithelial monolayers of LLC-PK1 cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane Permeability; Cimetidine; Epithelium; Hydrogen-Ion Concentration; Kidney; LLC-PK1 Cells; Nifedipine; Swine; Verapamil | 1996 |
Prediction of in vivo drug interaction from in vitro systems exemplified by interaction between verapamil and cimetidine using human liver microsomes and primary hepatocytes.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Liver; Microsomes, Liver; Rats; Rats, Wistar; Verapamil | 1997 |
Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression.
Topics: Animals; Atenolol; Biological Transport; Cell Line; Cell Membrane Permeability; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Erythromycin; Glucose; Humans; Mammals; Mannitol; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenylalanine; Propranolol; Recombinant Proteins; Testosterone; Tumor Cells, Cultured; Verapamil | 2000 |
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.
Topics: Acetylcholine; Amiloride; Cimetidine; Corticosterone; DNA, Antisense; Dose-Response Relationship, Drug; Female; Guanidine; Humans; In Vitro Techniques; Norepinephrine; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Piperidines; Placenta; Pregnancy; Procaine; Quinine; Time Factors; Verapamil | 2001 |
Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods.
Topics: Animals; Biological Transport, Active; Cimetidine; Drosophila melanogaster; Electrophysiology; Ion Transport; Malpighian Tubules; Microelectrodes; Potassium; Quinidine; Tetraethylammonium; Tetraphenylborate; Verapamil; Vinblastine | 2004 |
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cation Transport Proteins; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Cyclosporine; Endothelial Cells; Fluorescein; Membrane Potentials; Mice; Prion Diseases; Quinacrine; Tetraethylammonium; Verapamil | 2004 |
Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antitoxins; Cimetidine; Dose-Response Relationship, Drug; Electrophysiology; Histological Techniques; Ixodes; Male; Metoprolol; Microelectrodes; Microscopy, Electron; Myocardial Contraction; Myocardium; Pinacidil; Pyrilamine; Rats; Rats, Wistar; Spider Venoms; Tetrodotoxin; Verapamil | 2004 |
Interaction of aminoglycoside antibiotics with H2-blockers and calcium channel blockers in isolated smooth muscles of rat aorta.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Cimetidine; Histamine H2 Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ranitidine; Rats; Verapamil | 1989 |
Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons.
Topics: Animals; Animals, Newborn; Berberine; Biological Transport, Active; Cell Culture Techniques; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cimetidine; Coptis; Coptis chinensis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glycoproteins; Molecular Structure; Neurons; Organic Cation Transport Proteins; Rats; Spectrophotometry; Verapamil | 2008 |
Thiolated chitosan: development and in vitro evaluation of an oral delivery system for acyclovir.
Topics: Acyclovir; Adjuvants, Pharmaceutic; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chitin; Cimetidine; Drug Delivery Systems; Drug Evaluation, Preclinical; Electric Impedance; Glutathione; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Propranolol; Rats; Tablets; Verapamil | 2008 |
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosporine; Kidney; Liver; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Tetraethylammonium; Verapamil | 2009 |
Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats.
Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Chromatography, Liquid; Cimetidine; Guanine; Half-Life; Ion Pumps; Kidney; Male; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Probenecid; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Verapamil | 2011 |
Effects of dietary fruits, vegetables and a herbal tea on the in vitro transport of cimetidine: comparing the Caco-2 model with porcine jejunum tissue.
Topics: Animals; Beverages; Biological Transport; Caco-2 Cells; Cimetidine; Dietary Supplements; Food-Drug Interactions; Fruit; Humans; Intestinal Absorption; Jejunum; Plant Extracts; Swine; Vegetables; Verapamil | 2012 |
Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.
Topics: Animals; Cells, Cultured; Cimetidine; Dose-Response Relationship, Drug; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; Tacrine; Tetraethylammonium; Tissue Distribution; Verapamil | 2014 |
Modulatory effects of taurine on jejunal contractility.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Calcium Channel Blockers; Cimetidine; Diphenhydramine; Enteric Nervous System; Histamine H1 Antagonists; Histamine H2 Antagonists; Jejunum; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Nitric Oxide; Nitric Oxide Synthase; Phentolamine; Phosphorylation; Propranolol; Rats, Sprague-Dawley; Taurine; Tetrodotoxin; Verapamil | 2014 |
Evaluation of
Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil | 2017 |
Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Topics: Acyclovir; Animals; Biological Transport; Biomarkers; Bone Morphogenetic Protein 7; Carrier Proteins; Cell Culture Techniques; Cell Line, Transformed; Cell Lineage; Cimetidine; Cisplatin; Cyclic AMP; Cyclosporine; Digoxin; Doxorubicin; Drug Evaluation, Preclinical; Endocytosis; Extracellular Matrix; gamma-Glutamyltransferase; Humans; Kidney; Mice; Spheroids, Cellular; Toxicity Tests; Verapamil | 2019 |