verapamil and chlorthalidone

verapamil has been researched along with chlorthalidone in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19908 (29.63)18.7374
1990's10 (37.04)18.2507
2000's5 (18.52)29.6817
2010's4 (14.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Albanesi, FM; Albuquerque, DC; Benchimol, AB; Benchimol, CB; Rocha, PJ; Schlesinger, P1
Dal Palù, C; Magnani, B; Zanchetti, A1
Durel, LA; Hayashi, PJ; Schneiderman, N; Weidler, DJ1
Gerstenblith, G1
Hergueta García de Guadiana, G; Paumard Fraguas, A1
Achilli, L; D'Amico, F; Latini, R; Lombi, V; Pierandrei, G1
Ajzen, H; de Albuquerque, EM; Draibe, SA; Gelman, A; Reynaldo Stella, S1
Dobbs, RJ; Phillips, RJ; Robinson, BF1
Candau, LA; Pereira, LS; Scherr, C1
Barretto, AC; Godoy, M; Pileggi, F; Solorzano, J; Wajngarten, M1
Chequer, CV; Fernandes, EO; Latreca, CE; Reis, NB; Talberg, J1
Antonicelli, R; Gambini, C; Paciaroni, E; Sardina, M; Savonitto, S; Tomassini, PF1
Zanchetti, A1
Boehlen, L; Buechel, P; Lerch, M; Papiri, M; Risen, W; Schneider, M; Shaw, S; Weidmann, P1
de Leeuw, PW; Notter, T; Zilles, P1
Dal Palù, C; Leonetti, G; Magnani, B; Pessina, A; Rosei, EA; Zanchetti, A2
Gómez Guindal, JA; González Lama, I; González Maqueda, I1
Beck, K; Holzgreve, H; Janka, HU; Nakov, R1
Fomin, VV; Moiseev, SV1

Reviews

3 review(s) available for verapamil and chlorthalidone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Fixed-dose combination therapy: reduction of side effects with enhanced tolerance and antihypertensive efficacy].
    Revista espanola de cardiologia, 1999, Volume: 52 Suppl 3

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chlorthalidone; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Drug Tolerance; Humans; Hypertension; Indoles; Patient Compliance; Time Factors; Vasodilator Agents; Verapamil

1999
[Hypertension combined with atherosclerotic lesions in carotid arteries: should angiotensin converting enzyme inhibitors be prescribed?].
    Kardiologiia, 2005, Volume: 45, Issue:12

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Carotid Artery Diseases; Carotid Artery, Common; Chlorthalidone; Drug Therapy, Combination; Female; Fosinopril; Humans; Hypertension; Male; Middle Aged; Pravastatin; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Ultrasonography; Vasodilator Agents; Verapamil

2005

Trials

15 trial(s) available for verapamil and chlorthalidone

ArticleYear
Preliminary clinical experience with calcium antagonists in atherosclerosis. Verapamil in Hypertension Atherosclerosis Study Investigators.
    Drugs, 1992, Volume: 44 Suppl 1

    Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Carotid Arteries; Chlorthalidone; Delayed-Action Preparations; Double-Blind Method; Heart Rate; Humans; Hypertension; Middle Aged; Verapamil

1992
Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:6

    Topics: Adult; Ambulatory Care; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Pressure Determination; Chlorthalidone; Double-Blind Method; Drug Combinations; Humans; Hypertension; Metoprolol; Middle Aged; Monitoring, Physiologic; Office Visits; Verapamil

1992
Special considerations in the elderly patient.
    Journal of human hypertension, 1990, Volume: 4 Suppl 5

    Topics: Age Factors; Aged; Aging; Atenolol; Blood Pressure; Cardiac Output; Cardiomegaly; Chlorthalidone; Dose-Response Relationship, Drug; Echocardiography; Humans; Hypertension; Middle Aged; Myocardial Contraction; Risk Factors; Verapamil

1990
[Effects of a calcium antagonist, verapamil, on mild-moderate essential arterial hypertension].
    Anales de medicina interna (Madrid, Spain : 1984), 1989, Volume: 6, Issue:1

    Topics: Aged; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Verapamil

1989
[Hypotensive efficacy of verapamil alone and in combination with a diuretic in the treatment of essential hypertension in geriatric patients].
    Giornale italiano di cardiologia, 1987, Volume: 17, Issue:2

    Topics: Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Verapamil

1987
[Clinical evaluation of the effect of verapamil in hypertensive patients].
    Arquivos brasileiros de cardiologia, 1983, Volume: 40, Issue:1

    Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Placebos; Reserpine; Verapamil

1983
[Comparative study of the combination of chlorthalidone with verapamil and metoprolol in arterial hypertension: evaluation by cycloergometrics].
    Arquivos brasileiros de cardiologia, 1981, Volume: 37, Issue:2

    Topics: Adult; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil

1981
[Treatment of arterial hypertension in patients refractory to therapeutic diuretics. Comparative study of verapamil and propranolol].
    Arquivos brasileiros de cardiologia, 1982, Volume: 38, Issue:6

    Topics: Adult; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Propranolol; Verapamil

1982
Hemodynamic effects of cadralazine or chlorthalidone in verapamil-treated elderly hypertensives.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:4

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Male; Pyridazines; Verapamil

1994
Vascular complications in hypertension: the VHAS study. Verapamil-Hypertension Atherosclerosis Study.
    Cardiovascular drugs and therapy, 1995, Volume: 9 Suppl 3

    Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Blood Pressure; Chlorthalidone; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Verapamil

1995
Metabolic neutrality of combined verapamil-trandolapril treatment in contrast to beta-blocker-low-dose chlortalidone treatment in hypertensive type 2 diabetes.
    Journal of hypertension, 1996, Volume: 14, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Carbohydrate Metabolism; Chlorthalidone; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Indoles; Male; Middle Aged; Prospective Studies; Verapamil

1996
Comparison of different fixed antihypertensive combination drugs: a double-blind, placebo-controlled parallel group study.
    Journal of hypertension, 1997, Volume: 15, Issue:1

    Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Drug Tolerance; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Lisinopril; Male; Middle Aged; Safety; Verapamil

1997
Clinical results of the Verapamil inHypertension and Atherosclerosis Study. VHAS Investigators.
    Journal of hypertension, 1997, Volume: 15, Issue:11

    Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Calcium Channel Blockers; Chlorthalidone; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Verapamil

1997
The Verapamil in Hypertension and Atherosclerosis Study (VHAS): results of long-term randomized treatment with either verapamil or chlorthalidone on carotid intima-media thickness.
    Journal of hypertension, 1998, Volume: 16, Issue:11

    Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Arteriosclerosis; Basal Metabolism; Blood Pressure; Carotid Artery, Common; Chlorthalidone; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Reference Values; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography; Verapamil

1998
Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic control.
    American journal of hypertension, 2003, Volume: 16, Issue:5 Pt 1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Biomarkers; Blood Glucose; Blood Pressure; Chlorthalidone; Diabetes Mellitus, Type 2; Diastole; Diuretics; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Heart Rate; Humans; Hypertension; Indoles; Male; Middle Aged; Patient Compliance; Systole; Treatment Outcome; Vasodilator Agents; Verapamil

2003

Other Studies

9 other study(ies) available for verapamil and chlorthalidone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Effect of verapamil on the pressure response induced by cycloergometry in hypertensive patients].
    Arquivos brasileiros de cardiologia, 1979, Volume: 32, Issue:3

    Topics: Adult; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Exercise Test; Female; Humans; Hypertension; Male; Middle Aged; Oxygen Consumption; Verapamil

1979
Effect of treatment with chlorthalidone and atenolol on response to dilator agents in the forearm resistance vessels of men with primary hypertension.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:3

    Topics: Adult; Aged; Atenolol; Chlorthalidone; Forearm; Humans; Hypertension; Male; Middle Aged; Nitroprusside; Regional Blood Flow; Vascular Resistance; Vasodilator Agents; Verapamil

1983
[Verapamil as a hypotensive agent. Clinical, laboratory, electro- and echocardiographic study].
    Arquivos brasileiros de cardiologia, 1981, Volume: 36 Suppl 1

    Topics: Adult; Aged; Chlorthalidone; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Liver; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil

1981