verapamil and chloroquine

verapamil has been researched along with chloroquine in 115 studies

Research

Studies (115)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (13.04)	18.7374
1990's	39 (33.91)	18.2507
2000's	31 (26.96)	29.6817
2010's	30 (26.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alibert, S; Barbe, J; Houdoin, C; Karolak-Wojciechowska, J; Parzy, D; Pradines, B; Santelli-Rouvier, C	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Benoit-Vical, F; Berry, A; Garcia-Alvarez, MC; Nicolau, ML; Olagnier, D; Soh, PN; Witkowski, B	1
Pratim Roy, P; Roy, K	1
Ahman, M; Holmén, AG; Wan, H	1
Masseno, V; Muriithi, S; Nzila, A	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Fujii, H; Kobayashi, S; Miyata, Y; Nagase, H; Osa, Y; Takeuchi, T	1
Bettis, S; Brun, R; Fomovska, A; Huang, Q; Kaiser, M; Kozikowski, AP; McLeod, R; Mui, E; Pieroni, M; Stec, J; Witola, WH	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Basilico, N; Bernetti, M; Bonache de Marcos, MC; Brogi, S; Brun, R; Butini, S; Caccia, S; Camodeca, C; Campiani, G; Gemma, S; Gorelli, B; Guiso, G; Joshi, BP; Lamponi, S; Martin, RE; Moretti, V; Novellino, E; Parapini, S; Rottmann, M; Sanna Coccone, S; Saponara, S; Savini, L; Summers, RL; Taramelli, D	1
Bartolommei, G; Basilico, N; Brindisi, M; Brogi, S; Butini, S; Camodeca, C; Campiani, G; Fiorini, I; Gabellieri, E; Gemma, S; Gualdani, R; Habluetzel, A; Kukreja, G; Kunjir, S; Lamponi, S; Lucantoni, L; Martin, RE; Moncelli, MR; Novellino, E; Savini, L; Summers, RL; Tadini-Buoninsegni, F; Taramelli, D; Valoti, M	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Kong, LY; Lan, JS; Li, SY; Pan, LF; Wang, XB; Xie, SS	1
Joubert, J; Kapp, E; Malan, SF; Smith, PJ; Taylor, D	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cai, P; Kong, LY; Li, F; Wang, J; Wang, XB; Wu, JJ; Yang, XL	1
Chibale, K; Egan, TJ; Hunter, R; Joshi, MC; Ndove, J; Nsumiwa, S; Okombo, J; Taylor, D; Wiesner, L	1
Aguiar, ACC; Correia, CRD; Costa, JL; de Souza, GE; Garcia, CRS; Garcia, ML; Guido, RVC; Nakabashi, M; Oliva, G; Panciera, M; Simão Dos Santos, EF; Singh, MK	1
Cheuka, PM; Chibale, K; Lawrence, N; Taylor, D; Wittlin, S	1
Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA	1
Barnes, DA; Cowman, AF; Foote, SJ; Galatis, D; Kemp, DJ	1
Bray, PG; Howells, RE; Ritchie, GY; Ward, SA	1
Bhambhani, S; Biswas, S; Dewan, S; Valecha, N	1
Bass, GT; Gerena, L; Kyle, DE; Martin, RK; Milhous, WK; Oduola, AM	1
Kimata, I; Miki, A; Ohsawa, K; Tanabe, K	1
do Rosario, VE; Gluzman, IY; Gwadz, RW; Krogstad, DJ; Panton, LJ; Walker-Jonah, A; Wellems, TE	1
Bolívar, JJ; Cereijido, M; Chávez De Ramirez, B; Contreras, RG; Gonzalez-Mariscal, L; Ponce, A	1
Baguley, BC; Ferguson, LR; Turner, PM	1
Gluzman, IY; Krogstad, DJ; Martin, JT; Nkangineme, K; Orjih, AU; Schlesinger, PH; Wellems, TE	1
Bazill, GW; Dexter, TM	1
Anderson, SK; DeSantes, K; Geissler, F; Press, OW	1
Cutler, DJ; Ferrari, V	1
Doi, S; Hagiwara, A; Izumo, A; Kato, M; Tanabe, K	1
Van Dyke, K; Ye, ZG	1
Broxterman, HJ; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ	1
Safa, AR; Spearman, T; Van Dyke, K; Ye, ZG	1
Fitch, CD	1
Beck, WT; Cirtain, MC; Danks, MK; Felsted, RL; Safa, AR; Suttle, DP; Trent, JM; Wolverton, JS	1
Beck, WT; Cirtain, MC; Felsted, RL; Glover, CJ; Safa, AR	1
Aikawa, M; Jacobs, GH; Kyle, DE; Martin, SK; Milhous, WK; Oduola, AM	1
Beck, WT; Pearce, HL; Zamora, JM	1
Rosén, A; Szigeti, R	1
Brockelman, CR; Bunnag, D; Satayavivad, J; Tan-ariya, P; Wongsawatkul, O	1
Martin, SK; Milhous, WK; Oduola, AM	1
Drevon, CA; Nossen, JO; Rustan, AC; Tefre, T	1
Akiyama, S; Kuwano, M; Tomita, K	1
Akiyama, S	1
Clark, JS; Jubb, SN; Maloney, PJ; Young, JM	1
Chu, F; Cowman, AF; Gros, P; Karcz, S; Schurr, E; van Es, HH; Vidal, S	1
Bray, PG; Hawley, SR; Mungthin, M; Ward, SA	1
Cerami, A; Martiney, JA; Slater, AF	1
Chong, AS; Coon, JS; Gebel, HM; Markham, PN	1
Arnot, DE; Babiker, HA; Bayoumi, RA	1
Hess, FI; Kilian, A; Löscher, T; Nothdurft, HD; Pröll, S; Söllner, W	1
Boulter, MK; Bray, PG; Howells, RE; Ritchie, GY; Ward, SA	1
Bhaduri, AP; De, D; Milhous, WK	1
Kyle, DE; Milhous, WK; Rossan, RN	1
Marcil, J; Ravindranath, N; Sairam, MR	1
Arnot, DE; Sohal, AK	1
Borg, TK; Samarel, AM; Sharp, WW; Terracio, L	1
Bhaduri, AP; Seth, M; Walter, RD	1
Balkenende, AY; Slaper-Cortenbach, IC; van den Berg, H; van der Schoot, CE; Van Leeuwen, EF; Vervoordeldonk, SF; von dem Borne, AE	1
Bray, PG; Hawley, SR; Naisbitt, DJ; O'Neill, PM; Park, BK; Ward, SA	1
Chung, R; Cowman, AF; Foley, M; Riffkin, CD; Tilley, L; Wall, DM; Zalcberg, JR	1
Bray, PG; Green, JE; Hawley, SR; Mungthin, M; Ritchie, GY; Ward, SA	1
Arttamangkul, S; Poot, M	1
Balogh, Z; Fóris, G; Keresztes, T; Kovács, E; Leövey, A; Paragh, G; Szabolcs, M	1
Adovelande, J; Delèze, J; Schrével, J	1
Mangou, F; Platel, DF; Tribouley-Duret, J	1
Ayesh, S; Litman, T; Stein, WD	1
Boyer, JL; Hayes, JH; Rios-Velez, L; Soroka, CJ	1
Bray, PG; Ginsburg, H; Janneh, O; Mungthin, M; Raynes, KJ; Ward, SA	1
Bray, PG; Mungthin, M; Ward, SA	1
Frappier, F; Rafatro, H; Rakoto-Ratsimamanga, A; Ramanitrahasimbola, D; Rasoanaivo, P; Ratsimamanga-Urverg, S	1
Caruana, SR; Cowman, AF; Kirk, K; Reed, MB; Saliba, KJ	1
Dzekunov, SM; Roepe, PD; Ursos, LM	1
Cooper, RA; Deitsch, KW; Dzekunov, SM; Ferdig, MT; Fidock, DA; Naudé, B; Nomura, T; Roepe, PD; Sidhu, AB; Su, XZ; Talley, AK; Ursos, LM; Wellems, TE; Wootton, JC	1
Cooper, RA; Ferdig, MT; Fidock, DA; Fujioka, H; Mu, J; Nomura, T; Roepe, PD; Su, XZ; Ursos, LM; Wellems, TE	1
Fidock, DA; Sidhu, AB; Verdier-Pinard, D	1
Baker, J; Chen, N; Cheng, Q; Fowler, EV; Kyle, DE; Pasay, C; Peters, JM	1
Warhurst, DC	1
Bennett, TN; Dzekunov, S; Fidock, DA; Kosar, AD; Roepe, PD; Singh Sidhu, AB; Ursos, LM	1
Bray, PG; Fidock, DA; Johnson, DJ; Lakshmanan, V; Mungthin, M; Sidhu, AB; Ward, SA	1
Lanzer, M; McLean, JE; Sanchez, CP; Stein, W	1
Hayward, R; Kirk, K; Saliba, KJ	1
Lantvit, D; Lim, E; Pezzuto, JM; Tamez, PA	1
Alakpa, GE; Bray, PG; Fidock, DA; Horrocks, P; Hughes, RH; Johnson, DJ; Krogstad, DJ; Lakshmanan, V; Muhle, RA; Sidhu, AB; Verdier-Pinard, D; Ward, SA	1
Gbotosho, GO; Gerena, L; Happi, CT; Kyle, DE; Milhous, WK; Oduola, AM; Ogundahunsi, OA; Salako, LA; Sowunmi, A	1
Hayward, R; Kirk, K; Lehane, AM; Saliba, KJ	1
Bröer, S; Cowan, AI; Howitt, SM; Kirk, K; Marchetti, RV; Martin, RE	1
Checkley, L; Cooper, RA; Deng, B; Ferdig, MT; Gonzales, JM; Patel, JJ; Pleeter, P; Roepe, PD; Tan, JC; Thacker, D	1
Chen, MJ; Cheu, KW; Coghi, P; Guo, ZF; Guo, ZH; Haynes, RK; Li, KY; Monti, D; Tang, MM; Wong, HN	1
Papakrivos, J; Sá, JM; Wellems, TE	1
Choi, AR; Kim, JH; Kim, YK; Yoon, S	1
Chan, KW; Chow, LM; Choy, KY; Lear, MJ; Lee, YQ; Loh, CC; Nosten, FH; Rénia, L; Russell, B; Suwanarusk, R; Tan, KS	1
Bellanca, S; Dave, A; Dittmer, M; Lanzer, M; Martin, RE; Meyrath, M; Nash, MN; Sanchez, CP; Stein, WD; Summers, RL	1
Enomoto, M; Furuyama, W; Kawai, S; Kawazu, S; Mikoshiba, K; Mossaad, E	1
Fukui, T; Iwai, H; Juge, N; Kawakami, M; Miyaji, T; Moriyama, S; Moriyama, Y; Nelson, N; Omote, H	1
Kania, E; Litwiniuk, A; O'Prey, J; Orzechowski, A; Pająk, B; Ryan, KM; Sierra Gonzalez, P; Urbańska, K	1
Ariey, F; Dhingra, SK; Fairhurst, RM; Fidock, DA; Kümpornsin, K; Menard, D; Mok, S; Ross, LS; Takala-Harrison, S; Wicht, KJ; Witkowski, B; Yeo, T	1

Reviews

3 review(s) available for verapamil and chloroquine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. Progress in clinical and biological research, 1989, Volume: 313 Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Hemoglobins; Malaria; Plasmodium; Verapamil	1989
[Intracellular signal transmission of low density lipoprotein receptors in human monocytes]. Orvosi hetilap, 1997, Sep-07, Volume: 138, Issue:36 Suppl 2 Topics: Calcium Channel Blockers; Chloroquine; Cholesterol; Humans; Lipoproteins, LDL; Monocytes; Phospholipases; Protein Kinase C; Receptors, LDL; Verapamil	1997

Other Studies

112 other study(ies) available for verapamil and chloroquine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives. Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15 Topics: Animals; Anthracenes; Antimalarials; Chloroquine; CHO Cells; Cricetinae; Drug Resistance, Multiple; Erythrocytes; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	2002
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
In vitro and in vivo properties of ellagic acid in malaria treatment. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atovaquone; Chloroquine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ellagic Acid; Erythrocytes; Female; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Mice; Mice, Inbred Strains; Molecular Structure; Molecular Weight; Parasitemia; Parasitic Sensitivity Tests; Plasmodium; Plasmodium falciparum; Schizonts; Trophozoites	2009
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorganic & medicinal chemistry letters, 2011, Aug-15, Volume: 21, Issue:16 Topics: Antimalarials; Benzylidene Compounds; Chloroquine; Drug Resistance; Molecular Structure; Naltrexone; Parasitic Sensitivity Tests; Plasmodium chabaudi; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship	2011
Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7 Topics: Antimalarials; Benzamides; Imides; Leishmania donovani; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15 Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; Drug Resistance; Female; Half-Life; Hemeproteins; Humans; Malaria; Male; Membrane Transport Proteins; Mice; Models, Molecular; Mutation; Oocytes; Piperazines; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Ventricular Pressure; Xenopus laevis	2012
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23 Topics: Animals; Antimalarials; Benzoxazines; Cell Line; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Mimicry; Quinazolines; Spectrometry, Mass, Electrospray Ionization	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Carbolines; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Electrophorus; Horses; Humans; Molecular Docking Simulation; Protein Aggregation, Pathological; Tacrine	2014
Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum. Bioorganic & medicinal chemistry letters, 2016, Feb-15, Volume: 26, Issue:4 Topics: Adamantane; Amines; Animals; Antimalarials; Calcium Channels; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Inhibitory Concentration 50; Plasmodium falciparum; Protein Binding; Structure-Activity Relationship	2016
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. European journal of medicinal chemistry, 2017, Oct-20, Volume: 139 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzylamines; Blood-Retinal Barrier; Butyrylcholinesterase; Cell Death; Cholinergic Agents; Cholinesterase Inhibitors; Cinnamates; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Structure-Activity Relationship	2017
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice. Journal of medicinal chemistry, 2017, 12-28, Volume: 60, Issue:24 Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeability; Chloroquine; CHO Cells; Cricetulus; Drug Evaluation, Preclinical; Drug Resistance, Microbial; ERG1 Potassium Channel; Hemeproteins; Humans; Malaria; Male; Mice, Inbred BALB C; Plasmodium berghei; Plasmodium falciparum; Solubility; Structure-Activity Relationship	2017
Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity. Journal of medicinal chemistry, 2018, 07-12, Volume: 61, Issue:13 Topics: Animals; Antimalarials; Drug Design; Mice; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinolines	2018
Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles. MedChemComm, 2018, Oct-01, Volume: 9, Issue:10 Topics:	2018
Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. The Journal of biological chemistry, 1992, May-25, Volume: 267, Issue:15 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Compartmentation; Chloroquine; Daunorubicin; Deoxyglucose; Dinitrophenols; Drug Interactions; Drug Resistance; Energy Metabolism; Ethylmaleimide; Humans; Leukemia; Membrane Glycoproteins; Methylamines; Microscopy, Fluorescence; Monensin; Ouabain; Sodium Azide; Tumor Cells, Cultured; Vanadates; Verapamil	1992
Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. The EMBO journal, 1992, Volume: 11, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Deletion; Chromosome Mapping; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplification; Mefloquine; Membrane Glycoproteins; Plasmodium falciparum; Restriction Mapping; Verapamil	1992
Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. A correlation of chloroquine sensitivity with energy-dependent drug accumulation. Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7 Topics: Animals; Chloroquine; Drug Resistance; Hydrogen-Ion Concentration; Plasmodium falciparum; Time Factors; Verapamil	1992
Reversal of chloroquine resistance with verapamil in P. berghei in vivo. Indian journal of malariology, 1992, Volume: 29, Issue:1 Topics: Animals; Chloroquine; Drug Resistance; Mice; Plasmodium berghei; Verapamil	1992
Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:12 Topics: Animals; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Fluoxetine; Microbial Sensitivity Tests; Phenotype; Plasmodium falciparum; Verapamil	1992
Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi. Parasitology, 1991, Volume: 103 Pt 2 Topics: Animals; Chloroquine; Cytoplasm; Drug Interactions; Drug Resistance; Endoplasmic Reticulum; Female; Malaria; Mice; Microscopy, Electron; Plasmodium chabaudi; Vacuoles; Verapamil	1991
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature, 1990, May-17, Volume: 345, Issue:6272 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Chloroquine; Crosses, Genetic; Drug Resistance; Gene Amplification; Genes; Membrane Glycoproteins; Molecular Sequence Data; Oligonucleotide Probes; Phenotype; Plasmodium falciparum; Verapamil	1990
Role of calcium in tight junction formation between epithelial cells. The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1 Topics: Affinity Labels; Animals; Calcium; Calcium Channel Blockers; Cell Line; Chloroquine; Cytosol; Egtazic Acid; Electric Conductivity; Epithelium; Gallic Acid; Indoles; Intercellular Junctions; Kinetics; Mannitol; Microscopy, Electron; Microscopy, Electron, Scanning; Verapamil	1990
Protection by inhibitors of multidrug resistance against mitochondrial mutagenesis in Saccharomyces cerevisiae. European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:1 Topics: Aminoacridines; Chloroquine; Drug Resistance; Mitochondria; Mutagens; Mutation; Polysorbates; Saccharomyces cerevisiae; Verapamil	1990
A rapid in vitro test for chloroquine-resistant Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1990, Volume: 42, Issue:6 Topics: Animals; Anticoagulants; Cells, Cultured; Chloroquine; Drug Resistance; Erythrocytes; Leukocytes; Plasmodium falciparum; Predictive Value of Tests; Temperature; Verapamil	1990
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells. Cancer research, 1990, Dec-01, Volume: 50, Issue:23 Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil	1990
Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores. Cancer research, 1990, Feb-15, Volume: 50, Issue:4 Topics: Acid Phosphatase; Amantadine; Ammonium Chloride; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Chloroquine; Chromatography, High Pressure Liquid; Humans; Iodine Radioisotopes; Lysosomes; Mice; Monensin; Nigericin; Temperature; Tumor Cells, Cultured; Verapamil	1990
Uptake of chloroquine by human erythrocytes. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acids; Biological Transport; Blood Glucose; Carrier Proteins; Chloroquine; Choline; Diffusion; Erythrocyte Membrane; Erythrocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Nucleosides; Verapamil	1990
Plasmodium chabaudi: in vivo effects of Ca2+ antagonists on chloroquine-resistant and chloroquine-sensitive parasites. Experimental parasitology, 1990, Volume: 70, Issue:4 Topics: Animals; Calcium Channel Blockers; Chloroquine; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Female; Malaria; Mice; Mice, Inbred ICR; Nicardipine; Plasmodium; Verapamil	1990
Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. Biochemical and biophysical research communications, 1988, Aug-30, Volume: 155, Issue:1 Topics: Animals; Calcium; Chloroquine; Drug Interactions; Drug Resistance; Gallopamil; Ion Channels; Malaria; Plasmodium falciparum; Verapamil	1988
Glycolysis in P-glycoprotein-overexpressing human tumor cell lines. Effects of resistance-modifying agents. FEBS letters, 1989, Apr-24, Volume: 247, Issue:2 Topics: Adenosine Triphosphate; Amiloride; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Chloroquine; Cytochalasin B; Drug Resistance; Energy Metabolism; Glutathione Transferase; Glycolysis; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Membrane Glycoproteins; Monensin; Nigericin; Oxygen Consumption; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil	1989
3H-azidopine photoaffinity labeling of high molecular weight proteins in chloroquine resistant falciparum malaria. Biochemical and biophysical research communications, 1989, Jul-31, Volume: 162, Issue:2 Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Chloroquine; Chlorpromazine; Dihydropyridines; Drug Resistance; Glycoproteins; Molecular Weight; Nicardipine; Photochemistry; Plasmodium falciparum; Proteins; Quinacrine; Reserpine; Trifluoperazine; Verapamil	1989
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells. Cancer research, 1987, Oct-15, Volume: 47, Issue:20 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Banding; Chromosomes, Human, Pair 13; Colchicine; Dactinomycin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia; Membrane Glycoproteins; Molecular Weight; Podophyllotoxin; Teniposide; Tumor Cells, Cultured; Verapamil; Vinblastine; Vinca Alkaloids	1987
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine. Biochemical and biophysical research communications, 1988, Jun-30, Volume: 153, Issue:3 Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Chloroquine; Drug Interactions; Drug Resistance; Humans; Indoles; Leukemia; Membrane Glycoproteins; Photochemistry; Quinacrine; Quinine; Reserpine; Verapamil; Vinblastine; Vinca Alkaloids; Vindesine; Yohimbine	1988
Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1988, Volume: 39, Issue:1 Topics: Animals; Chloroquine; Drug Interactions; Drug Resistance; Microscopy, Electron; Plasmodium falciparum; Vacuoles; Verapamil	1988
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Molecular pharmacology, 1988, Volume: 33, Issue:4 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physical; Chloroquine; Computer Simulation; Doxorubicin; Drug Resistance; Humans; Leukemia; Naphthacenes; Podophyllotoxin; Quinacrine; Verapamil; Vinca Alkaloids	1988
Studies on leukocyte migration inhibitory factor (LIF) produced by activated T and B cells. Lymphokine research, 1988,Spring, Volume: 7, Issue:1 Topics: B-Lymphocytes; Chloroquine; Humans; In Vitro Techniques; Kinetics; Leukocyte Migration-Inhibitory Factors; Lymphocyte Activation; Lymphokines; Molecular Weight; Polymyxin B; T-Lymphocytes; Verapamil	1988
Flunarizine and verapamil inhibit chloroquine-resistant Plasmodium falciparum growth in vitro. The Southeast Asian journal of tropical medicine and public health, 1987, Volume: 18, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Chlorpromazine; Drug Resistance; Flunarizine; Mefloquine; Plasmodium falciparum; Quinine; Quinolines; Regression Analysis; Verapamil	1987
Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science (New York, N.Y.), 1987, Feb-20, Volume: 235, Issue:4791 Topics: Animals; Biological Transport; Chloroquine; Drug Resistance; Drug Synergism; Plasmodium falciparum; Verapamil	1987
Inhibition of very-low-density lipoprotein secretion by chloroquine, verapamil and monensin takes place in the Golgi complex. Biochimica et biophysica acta, 1987, Oct-01, Volume: 930, Issue:3 Topics: Animals; Chloroquine; Golgi Apparatus; Kinetics; Lipoproteins, VLDL; Liver; Male; Mathematics; Microscopy, Electron; Models, Biological; Monensin; Rats; Verapamil	1987
The effect of calcium antagonists on the proteolytic degradation of low-density lipoprotein in HeLa cells. Experimental cell research, 1985, Volume: 158, Issue:1 Topics: Calcium Channel Blockers; Cell Compartmentation; Chloroquine; Cholesterol; Endocytosis; Female; Gallopamil; HeLa Cells; Humans; Kinetics; Lipoproteins, LDL; Lysosomes; Peptide Hydrolases; Verapamil	1985
[The effect of calcium antagonists on intracellular transport of epidermal growth factor and the conjugate of epidermal growth factor with pseudomonas exotoxin]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:3 Pt 2 Topics: Biological Transport; Calcium Channel Blockers; Cathepsin B; Cathepsins; Cell Line; Cell Survival; Cells, Cultured; Chloroquine; Endotoxins; Enzyme Activation; Epidermal Growth Factor; Gallopamil; Humans; Lysosomes; Neoplasms, Experimental; Nifedipine; Pseudomonas aeruginosa; Verapamil	1985
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. Prostaglandins, 1985, Volume: 30, Issue:4 Topics: Anaphylaxis; Animals; Chloroquine; Chlortetracycline; Dexamethasone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; Naproxen; Nicardipine; Nifedipine; Platelet Activating Factor; Pyrazoles; Quinacrine; Tetracycline; Verapamil	1985
Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine. Molecular and cellular biology, 1994, Volume: 14, Issue:4 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport; Cell Survival; Chloroquine; CHO Cells; Colchicine; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Protozoan; Doxorubicin; Drug Resistance; Female; Gene Expression; Genes, Protozoan; Membrane Proteins; Oligonucleotides, Antisense; Oocytes; Plasmodium falciparum; Primaquine; Protozoan Proteins; Quinine; Restriction Mapping; Verapamil; Vinblastine; Xenopus laevis	1994
Current views on the mechanisms of resistance to quinoline-containing drugs in Plasmodium falciparum. Annals of tropical medicine and parasitology, 1995, Volume: 89, Issue:2 Topics: Animals; Antimalarials; Biological Transport; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Phenanthrenes; Plasmodium falciparum; Verapamil	1995
Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38 Topics: Animals; Biological Transport; Chloroquine; Drug Resistance; Erythrocytes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Plasmodium falciparum; Structure-Activity Relationship; Verapamil	1995
Natural killer cell cytotoxicity and the multidrug resistance gene. Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1 Topics: CD8 Antigens; Chloroquine; Cyclosporine; Cytotoxicity, Immunologic; DNA; Drug Resistance; Humans; Killer Cells, Natural; Membrane Glycoproteins; Perforin; Polyethylene Glycols; Polymerase Chain Reaction; Pore Forming Cytotoxic Proteins; RNA; Stearic Acids; T-Lymphocytes, Cytotoxic; Verapamil	1993
Uptake and efflux of chloroquine by chloroquine-resistant Plasmodium falciparum clones recently isolated in Africa. Acta tropica, 1994, Volume: 58, Issue:2 Topics: Africa; Animals; Chloroquine; Desipramine; Drug Resistance; Erythrocytes; Plasmodium falciparum; Verapamil	1994
Plasmodium falciparum and Plasmodium berghei: effect of magnesium on the development of parasitemia. Experimental parasitology, 1995, Volume: 80, Issue:2 Topics: Analysis of Variance; Animals; Calcium; Chloroquine; Culture Media; Dose-Response Relationship, Drug; Drug Resistance; Erythrocytes; Female; Magnesium; Malaria; Mice; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Time Factors; Verapamil	1995
Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. Molecular and biochemical parasitology, 1994, Volume: 63, Issue:1 Topics: Animals; Biological Transport, Active; Chloroquine; Desipramine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Kinetics; Malaria, Falciparum; Plasmodium falciparum; Verapamil	1994
A novel pyrrolidonoalkaneamine (WR268954) that modulates chloroquine resistance of Plasmodium falciparum in vitro. The American journal of tropical medicine and hygiene, 1993, Volume: 49, Issue:1 Topics: Animals; Anisoles; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Molecular Structure; Plasmodium falciparum; Pyrrolidines; Quinine; Verapamil	1993
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:1 Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; Disease Models, Animal; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Ketotifen; Malaria, Falciparum; Plasmodium falciparum; Prochlorperazine; Propylamines; Verapamil	1993
Cytotoxic activity of lutropin-gelonin conjugate in mouse Leydig tumor cells: potentiation of the hormonotoxin activity by different drugs. Molecular and cellular endocrinology, 1993, Volume: 92, Issue:1 Topics: Animals; Antineoplastic Agents; Chloroquine; Drug Screening Assays, Antitumor; Drug Synergism; Leydig Cell Tumor; Leydig Cells; Luteinizing Hormone; Male; Mice; Monensin; Neoplasm Proteins; Plant Proteins; Progesterone; Protein Synthesis Inhibitors; Quinacrine; Receptors, LH; Ribosome Inactivating Proteins, Type 1; Testicular Neoplasms; Tumor Cells, Cultured; Verapamil	1993
Plasmodium chabaudi: a short-term in vitro culture method and its application to chloroquine resistance testing. Experimental parasitology, 1993, Volume: 76, Issue:3 Topics: Animals; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Erythrocytes; Mice; Plasmodium chabaudi; Verapamil	1993
Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circulation research, 1993, Volume: 73, Issue:1 Topics: Actins; Animals; Animals, Newborn; Cells, Cultured; Chloroquine; Membrane Potentials; Myocardial Contraction; Myocardium; Myofibrils; Rats; Sarcomeres; Tetradecanoylphorbol Acetate; Time Factors; Verapamil	1993
Reversal of chloroquine resistance in Plasmodium falciparum by CDR 87/209 and analogues. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1993, Volume: 44, Issue:1 Topics: Animals; Chloroquine; Drug Interactions; Drug Resistance; Molecular Structure; Plasmodium falciparum; Pyrrolidines; Verapamil	1993
Degradation of radioiodinated B cell monoclonal antibodies: inhibition via a FCgamma-receptor-II-mediated mechanism and by drugs. Cancer immunology, immunotherapy : CII, 1996, Volume: 42, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; B-Lymphocytes; Biological Transport; Burkitt Lymphoma; Calcium Channel Blockers; Cell Adhesion Molecules; Chloroquine; Colchicine; Etoposide; Humans; Immunoglobulin Isotypes; Immunotoxins; Iodine Radioisotopes; Lectins; Leukemia, B-Cell; Mice; Monensin; Paclitaxel; Radioimmunotherapy; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 2; Verapamil; Vinblastine; Vincristine	1996
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:10 Topics: Alkylation; Amodiaquine; Animals; Antimalarials; Calcium Channel Blockers; Cell Survival; Chemical Phenomena; Chemistry, Physical; Chloroquine; Drug Resistance; Glutathione; Humans; In Vitro Techniques; Leukocytes; Plasmodium falciparum; Verapamil	1996
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochemical pharmacology, 1996, Nov-22, Volume: 52, Issue:10 Topics: Affinity Labels; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Biological Transport, Active; Chloroquine; Drug Interactions; Drug Resistance, Multiple; Fluorescent Dyes; Humans; Kinetics; Mefloquine; Neoplasms; Prazosin; Tumor Cells, Cultured; Verapamil; Vinblastine	1996
In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1. Molecular and biochemical parasitology, 1996, Dec-02, Volume: 83, Issue:1 Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Transport; Chloroquine; DNA Fingerprinting; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Gene Dosage; Gene Expression; Immunoblotting; Mefloquine; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Selection, Genetic; Sequence Analysis, DNA; Verapamil	1996
Verapamil inhibition of enzymatic product efflux leads to improved detection of beta-galactosidase activity in lacZ-transfected cells. Cytometry, 1997, May-01, Volume: 28, Issue:1 Topics: 3T3 Cells; alpha-Galactosidase; Animals; beta-Galactosidase; Cell Line; Chloroquine; Chromatography, High Pressure Liquid; Fibroblasts; Flow Cytometry; Fluoresceins; Galactosides; Gene Expression; Lac Operon; Lysosomes; Mice; Substrate Specificity; Transfection; Verapamil	1997
Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochemical pharmacology, 1998, Feb-15, Volume: 55, Issue:4 Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Indolizines; Malaria, Falciparum; Phenethylamines; Plasmodium falciparum; Verapamil	1998
High-level chloroquine resistance of Plasmodium berghei is associated with multiple drug resistance and loss of reversal by calcium antagonists. International journal for parasitology, 1998, Volume: 28, Issue:4 Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Drug Synergism; Malaria; Mice; Nicardipine; Plasmodium berghei; Verapamil	1998
Drug accumulation in the presence of the multidrug resistance pump: dissociation between verapamil accumulation and the action of P-glycoprotein. Receptors & channels, 1997, Volume: 5, Issue:3-4 Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Daunorubicin; Drug Resistance, Multiple; Mice; Tumor Cells, Cultured; Verapamil; Vinblastine	1997
Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the Rat. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:2 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Bile Canaliculi; Biological Transport; Bucladesine; Cations; Chloroquine; Daunorubicin; Kinetics; Liver; Macrolides; Male; Mitochondrial Proteins; Nocodazole; Rats; Rats, Wistar; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Taurocholic Acid; Verapamil	1999
Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum. The Journal of cell biology, 1999, Apr-19, Volume: 145, Issue:2 Topics: Amiloride; Animals; Antimalarials; Bicarbonates; Biological Transport; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemin; Hemoglobins; Humans; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Plasmodium falciparum; Sodium-Hydrogen Exchangers; Verapamil	1999
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand. The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:3 Topics: Animals; Antimalarials; Blotting, Western; Chloroquine; DNA Fingerprinting; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Gene Dosage; Genotype; Humans; Malaria, Falciparum; Mefloquine; Penfluridol; Phenanthrenes; Phenotype; Plasmodium falciparum; Polymerase Chain Reaction; Quinine; Thailand; Verapamil	1999
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria. Biochemical pharmacology, 2000, May-01, Volume: 59, Issue:9 Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Interactions; Drug Resistance; Malaria, Falciparum; Mice; Plasmodium falciparum; Plasmodium yoelii; Solubility; Verapamil	2000
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature, 2000, Feb-24, Volume: 403, Issue:6772 Topics: Amino Acid Substitution; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Mefloquine; Mutation; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Sesquiterpenes; Verapamil	2000
The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine. Molecular and biochemical parasitology, 2000, Volume: 110, Issue:1 Topics: Acridine Orange; Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Parasitic Sensitivity Tests; Photometry; Plasmodium falciparum; Vacuoles; Verapamil	2000
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Molecular cell, 2000, Volume: 6, Issue:4 Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Chloroquine; Digestive System; Drug Resistance; Exons; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Polymerase Chain Reaction; Protozoan Proteins; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Transfection; Vacuoles; Verapamil	2000
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Molecular pharmacology, 2002, Volume: 61, Issue:1 Topics: Acridine Orange; Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Interactions; Drug Resistance; Fluorescence; Membrane Proteins; Membrane Transport Proteins; Molecular Conformation; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil	2002
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science (New York, N.Y.), 2002, Oct-04, Volume: 298, Issue:5591 Topics: Alleles; Amodiaquine; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Genes, Protozoan; Haplotypes; Mefloquine; Membrane Proteins; Membrane Transport Proteins; Parasitic Sensitivity Tests; Phenotype; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinine; Sesquiterpenes; Transfection; Verapamil	2002
pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:11 Topics: Alleles; Amino Acid Substitution; Amino Acids; Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Codon; Drug Resistance; Genes, Protozoan; Humans; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Mutation; Philippines; Plasmodium falciparum; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Protozoan; Verapamil	2003
Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. Malaria journal, 2003, Sep-19, Volume: 2 Topics: Amodiaquine; Animals; Antimalarials; Cell Line; Chloride Channels; Chloroquine; Drug Resistance; Drug Synergism; Hydrophobic and Hydrophilic Interactions; Ion Channels; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Transfection; Verapamil	2003
Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH. Molecular and biochemical parasitology, 2004, Volume: 133, Issue:1 Topics: Acridine Orange; Alleles; Animals; Antimalarials; Chloroquine; Cytophotometry; Drug Resistance; Hydrogen-Ion Concentration; Membrane Proteins; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins; Recombination, Genetic; Vacuoles; Verapamil	2004
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Molecular cell, 2004, Sep-24, Volume: 15, Issue:6 Topics: Alanine; Alleles; Amantadine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Genes, Protozoan; Haplotypes; Hemin; Membrane Proteins; Membrane Transport Proteins; Microsatellite Repeats; Molecular Sequence Data; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Point Mutation; Protein Structure, Secondary; Protozoan Proteins; Recombination, Genetic; Verapamil	2004
Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains. Biochemistry, 2004, Dec-28, Volume: 43, Issue:51 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carrier Proteins; Chloroquine; Drug Resistance; Plasmodium falciparum; Substrate Specificity; Verapamil	2004
Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:2 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chloroquine; Drug Resistance; Mutation; Plasmodium falciparum; Verapamil	2005
Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum. Journal of ethnopharmacology, 2005, Apr-08, Volume: 98, Issue:1-2 Topics: Alkaloids; Animals; Benzylisoquinolines; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Inhibitory Concentration 50; KB Cells; Malaria, Falciparum; Male; Mice; Parasitemia; Parasitic Sensitivity Tests; Plasmodium berghei; Quinine; Verapamil	2005
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. The EMBO journal, 2005, Jul-06, Volume: 24, Issue:13 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Hemin; Membrane Proteins; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins; Verapamil	2005
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum. Annals of tropical medicine and parasitology, 2006, Volume: 100, Issue:7 Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Chlorpheniramine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Histamine H1 Antagonists; Orosomucoid; Plasmodium falciparum; Promethazine; Verapamil	2006
A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites. Journal of cell science, 2008, May-15, Volume: 121, Issue:Pt 10 Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Resistance; Enzyme Inhibitors; Hydrogen; Hydrogen-Ion Concentration; Macrolides; Permeability; Plasmodium falciparum; Proton Pumps; Vacuoles; Verapamil	2008
Chloroquine transport via the malaria parasite's chloroquine resistance transporter. Science (New York, N.Y.), 2009, Sep-25, Volume: 325, Issue:5948 Topics: Amino Acid Sequence; Animals; Antimalarials; Biological Transport; Cell Membrane; Chloroquine; Drug Resistance; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Transport Proteins; Molecular Sequence Data; Mutant Proteins; Mutation; Oligopeptides; Oocytes; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins; Verapamil; Xenopus laevis	2009
Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross. Molecular microbiology, 2010, Volume: 78, Issue:3 Topics: Antimalarials; Chloroquine; Drug Resistance; Gene Dosage; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins; Quantitative Trait Loci; Verapamil	2010
A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine. ChemMedChem, 2011, Sep-05, Volume: 6, Issue:9 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Flavin-Adenine Dinucleotide; Homeostasis; Humans; Malaria; Methylene Blue; Oxidation-Reduction; Verapamil	2011
Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. PloS one, 2012, Volume: 7, Issue:6 Topics: Adenosine Triphosphate; Ammonia; Animals; Antimalarials; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Transformed; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Hydrogen-Ion Concentration; Ionophores; Macrolides; Membrane Potentials; Membrane Transport Proteins; Phenotype; Plasmodium falciparum; Potassium; Protozoan Proteins; Valinomycin; Verapamil	2012
Co-treatment with the anti-malarial drugs mefloquine and primaquine highly sensitizes drug-resistant cancer cells by increasing P-gp inhibition. Biochemical and biophysical research communications, 2013, Nov-22, Volume: 441, Issue:3 Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chloroquine; Doxycycline; Drug Resistance, Neoplasm; Humans; Mefloquine; Primaquine; Verapamil; Vinblastine	2013
Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. PloS one, 2014, Volume: 9, Issue:10 Topics: Adenosine Triphosphate; Animals; Biomarkers; Boron Compounds; Chloroquine; DNA Copy Number Variations; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Inhibitory Concentration 50; Mibefradil; Microsomes; Molecular Probe Techniques; Parasites; Plasmodium falciparum; Polymorphism, Genetic; Reproducibility of Results; Verapamil	2014
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites. The Journal of biological chemistry, 2014, Dec-26, Volume: 289, Issue:52 Topics: Animals; Antimalarials; Binding Sites; Binding, Competitive; Biological Transport; Cells, Cultured; Chloroquine; Drug Resistance; Female; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil; Xenopus laevis	2014
Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:5 Topics: Animals; Antimalarials; Chloroquine; Female; Inhibitory Concentration 50; Malaria; Mice; Mice, Inbred ICR; Plasmodium falciparum; Verapamil	2015
Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter. Proceedings of the National Academy of Sciences of the United States of America, 2015, Mar-17, Volume: 112, Issue:11 Topics: Amino Acids; Biological Transport; Chloroquine; Drug Resistance; Membrane Transport Proteins; Protons; Protozoan Proteins; Tetraethylammonium; Verapamil	2015
Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism. The FEBS journal, 2017, Volume: 284, Issue:9 Topics: Antimalarials; Antineoplastic Agents; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Biomarkers; Calcium Channel Blockers; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Cells, Cultured; Chloroquine; CRISPR-Cas Systems; Cytoprotection; Energy Metabolism; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Microscopy, Electron, Transmission; Neoplasms; Verapamil	2017
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine. Nature communications, 2018, 08-17, Volume: 9, Issue:1 Topics: Animals; Antimalarials; Cambodia; Cell Shape; Chloroquine; Drug Resistance; Gene Dosage; Gene Editing; Haplotypes; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins; Quinolines; Verapamil	2018