verapamil has been researched along with carbamazepine in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (10.26) | 18.7374 |
| 1990's | 12 (15.38) | 18.2507 |
| 2000's | 21 (26.92) | 29.6817 |
| 2010's | 31 (39.74) | 24.3611 |
| 2020's | 6 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Anger, T; Madge, DJ; Mulla, M; Riddall, D | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ara, T; Arnold, LA; Baranowski, AM; Bikle, DD; Guy, RK; Lynt, WZ; McCallum, MM; Nandhikonda, P; Pearson, D; Yuan, NY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Arnold, LA; Bikle, DD; Cook, JM; Feleke, B; McCallum, MM; Nandhikonda, P; Nassif, N; Sidhu, PS; Singh, RK; Teske, K; Yuan, NY | 1 |
| Li, F; Liu, Y; Wang, W; Wu, L; Yan, B; Zhang, Q; Zhou, H; Zhu, H | 1 |
| Connelly, M; Fatima, I; Gautam, LN; González, MA; Ling, T; Miranda-Carboni, G; Rivas, F; Tran, M; Wood, RK | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V | 1 |
| Arnold, LA; Balakrishnan, K; Chen, W; Fan, H; Fan, Y; Gandhi, V; Peng, X; Sun, H; Wang, Y | 1 |
| Bassett, R; Budhraja, A; Das, S; Ling, T; Maier, J; Opferman, JT; Potts, MB; Rankovic, Z; Rivas, F; Shelat, A | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Cai, G; Cai, J; Calcul, L; Cheng, F; Jia, R; Li, C; Li, Q; Luo, X; She, F; Sun, X; Wang, D; Wang, S; Wang, Y; Wei, L; Yu, J; Zheng, M; Zhou, M | 1 |
| Dong, S; Gao, JM; He, QR; Huang, LF; Tang, JJ; Wang, MR | 1 |
| Bingmann, D; Düsing, R; Grunze, H; Liu, Z; Walden, J | 1 |
| Bahls, FH; Ozuna, J; Ritchie, DE | 1 |
| Elliott, P | 1 |
| Cookson, JC | 1 |
| Brodie, MJ; Macphee, GJ; McInnes, GT; Thompson, GG | 1 |
| Ochodnický, M | 1 |
| DiMarzio, LR; Price, WA | 1 |
| Beattie, B; Biller, J; Mehlhaus, B; Murray, M | 1 |
| Hauswirth, O; Singh, BN | 1 |
| Bacher, NM; Lewis, HA | 1 |
| Klemfuss, H; Kripke, DF | 1 |
| Bushnell, DL; Hines, ME; Manshadi, FF; Roberts, MA | 1 |
| Berger, M; Roed, I; von Wegerer, J; Walden, J | 1 |
| Bingmann, D; Düsing, R; Grunze, H; Liu, Z; Mayer, A; Schirrmacher, K; Walden, J | 1 |
| Rothschild, AJ | 1 |
| Monzillo, PH; Peres, MF; Sanvito, WL | 1 |
| Ngan, ET; Vincent, SR | 1 |
| Boerlin, HL; Gitlin, MJ; Hammen, CL; Zoellner, LA | 1 |
| Lazarova, M; Petkova, B; Staneva-Stoycheva, D | 1 |
| Chadwick, D; Morgan, P; Owen, A; Park, BK; Pirmohamed, M; Tettey, JN | 1 |
| Kivistö, KT; Lapatto-Reiniluoto, O; Neuvonen, PJ | 1 |
| Fedrowitz, M; Löscher, W; Potschka, H | 1 |
| Auchère, D; Bonhomme-Faivre, L; Farinotti, R; Forestier, F; Orbach-Arbouys, S; Soursac, M | 1 |
| Boes, CJ; Goadsby, PJ; Matharu, MS | 1 |
| Liu, HY; Liu, X; Liu, XD; Liu, YC; Wang, GJ; Xie, L; Yang, HW; Zhang, DM | 1 |
| Kozminski, M | 1 |
| Caraballo, I; Gonçalves-Araújo, T; Rajabi-Siahboomi, AR | 1 |
| Koester, LS; Kratz, JM; Simões, CM; Teixeira, MR | 1 |
| Aguilar-de-Leyva, A; Caraballo, I; Cifuentes, C; Rajabi-Siahboomi, AR | 1 |
| Chen, Y; Ma, A; Wang, C; Yuan, W | 1 |
| Böttcher, C; Carter, LJ; Kookana, RS; Williams, M | 1 |
| Alexandre Junior, V; Antunes, Nde J; Coelho, EB; Della Pasqua, O; Lanchote, VL; Marques, MP; Takayanagui, OM; Tozatto, E; Wichert-Ana, L | 1 |
| Alexandre Junior, V; Antunes, NJ; Coelho, EB; Della Pasqua, O; Lanchote, VL; Takayanagui, OM; Tozatto, E; van Dijkman, SC; van Hasselt, JGC; Wichert-Ana, L | 1 |
| Abbasova, K; Anshakova, A; Baklaushev, V; Balabanyan, V; Chekhonin, V; Gelperina, S; Kreuter, J; Maksimenko, O; Malinovskaya, J; Melnikov, P; Titov, S; Zybina, A | 1 |
| Alves, G; Falcão, A; Ferreira, A; Fortuna, A; Meirinho, S; Rodrigues, M | 1 |
| Gilmore, IS; Hanley, L; Pieterse, CL; Rungger, I; Wickramasinghe, RC | 1 |
| Boboc, IKS; Bogdan, M; Calina, D; Catalin, B; Cojocaru, A; Nedelea, G | 1 |
5 review(s) available for verapamil and carbamazepine
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Models, Molecular; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Sodium Channel Blockers; Sodium Channels; Stroke | 2001 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug treatment of bipolar depression and mania.
Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Bromocriptine; Carbamazepine; Cholinesterase Inhibitors; Clonidine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium; Monoamine Oxidase Inhibitors; Phosphatidylcholines; Tryptophan; Valproic Acid; Verapamil | 1985 |
Comparative mechanisms of action of antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans; Benzyl Compounds; Bretylium Compounds; Calcium; Carbamazepine; Chemical Phenomena; Chemistry; Diethylamines; Disopyramide; Heart; Humans; Imidazoles; Iodobenzoates; Lidocaine; Membrane Potentials; Phenyl Ethers; Phenytoin; Procainamide; Propylamines; Quinidine; Verapamil | 1974 |
Management of psychotic, treatment-resistant depression.
Topics: Affect; Affective Disorders, Psychotic; Antidepressive Agents; Antipsychotic Agents; Carbamazepine; Chemotherapy, Adjuvant; Delusions; Depressive Disorder; Drug Resistance; Drug Therapy, Combination; Electroconvulsive Therapy; Hallucinations; Hydrocortisone; Verapamil | 1996 |
5 trial(s) available for verapamil and carbamazepine
| Article | Year |
|---|---|
Verapamil potentiates carbamazepine neurotoxicity: a clinically important inhibitory interaction.
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Dizziness; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Seizures; Time Factors; Verapamil | 1986 |
Bipolar depression and antidepressant-induced mania: a naturalistic study.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; Carbamazepine; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Follow-Up Studies; Humans; Lithium; Male; Monoamine Oxidase Inhibitors; Selective Serotonin Reuptake Inhibitors; Valproic Acid; Verapamil | 1998 |
Activated charcoal alone and followed by whole-bowel irrigation in preventing the absorption of sustained-release drugs.
Topics: Adult; Anticonvulsants; Antidotes; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Carbamazepine; Charcoal; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Intestinal Absorption; Male; Theophylline; Therapeutic Irrigation; Verapamil | 2001 |
Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Oxcarbazepine; Stereoisomerism; Verapamil; Young Adult | 2016 |
Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carbamazepine; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Oxcarbazepine; Seizures; Stereoisomerism; Verapamil; Young Adult | 2017 |
68 other study(ies) available for verapamil and carbamazepine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
Topics: Cell Line; High-Throughput Screening Assays; Humans; Indoles; Membranes, Artificial; Methylamines; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivator 3; Nuclear Receptor Coactivators; Permeability; Protein Binding; Receptors, Calcitriol; Solubility; Structure-Activity Relationship; Transcription, Genetic; TRPV Cation Channels | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
Topics: | 2014 |
Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; High-Throughput Screening Assays; Humans; Molecular Structure; Small Molecule Libraries; Solubility; Structure-Activity Relationship; Thiazolidines; Water | 2015 |
(+)-Dehydroabietylamine derivatives target triple-negative breast cancer.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Triple Negative Breast Neoplasms | 2015 |
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents.
Topics: Antineoplastic Agents, Alkylating; Boronic Acids; Cell Line, Tumor; Drug Design; Esters; Humans; Hydrogen Peroxide; Nitrogen Mustard Compounds | 2018 |
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Induction; Heterocyclic Compounds; Humans; Leukemia; Mice; Small Molecule Libraries; Therapeutic Index | 2019 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR.
Topics: Dose-Response Relationship, Drug; Drug Discovery; ErbB Receptors; Ligands; Molecular Structure; Peptidomimetics; Structure-Activity Relationship | 2021 |
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Topics: Anti-Inflammatory Agents; Humans; Models, Molecular; Neuroinflammatory Diseases; NF-kappa B; Sesquiterpenes, Eudesmane; Structure-Activity Relationship; Toll-Like Receptor 4 | 2021 |
Calcium antagonistic effects of carbamazepine as a mechanism of action in neuropsychiatric disorders: studies in calcium dependent model epilepsies.
Topics: Animals; Calcium Channel Blockers; Carbamazepine; Epilepsy; Extracellular Space; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; Microelectrodes; N-Methylaspartate; Psychotic Disorders; Verapamil | 1992 |
Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Carbamazepine; Diltiazem; Drug Interactions; Female; Humans; Male; Middle Aged; Nifedipine; Phenytoin; Retrospective Studies; Seizures; Verapamil | 1991 |
Action of antiepileptic and anaesthetic drugs on Na- and Ca-spikes in mammalian non-myelinated axons.
Topics: Action Potentials; Anesthetics; Animals; Anticonvulsants; Axons; Calcium; Carbamazepine; Dose-Response Relationship, Drug; Flurazepam; Lidocaine; Procaine; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1990 |
[Clinically important interactions of carbamazepine with verapamil and diltiazem].
Topics: Carbamazepine; Diltiazem; Drug Interactions; Humans; Verapamil | 1988 |
Verapamil-carbamazepine neurotoxicity.
Topics: Bipolar Disorder; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Middle Aged; Nervous System Diseases; Verapamil | 1988 |
Verapamil-induced carbamazepine neurotoxicity. A report of two cases.
Topics: Adult; Ataxia; Carbamazepine; Drug Interactions; Female; Humans; Middle Aged; Seizures; Verapamil | 1988 |
Verapamil and depression.
Topics: Bipolar Disorder; Carbamazepine; Depressive Disorder; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Verapamil | 1984 |
Antimanic drugs stabilize hamster circadian rhythms.
Topics: Animals; Arousal; Carbamazepine; Circadian Rhythm; Cricetinae; Dose-Response Relationship, Drug; Drug Administration Schedule; Lithium Carbonate; Male; Mesocricetus; Motor Activity; Psychotropic Drugs; Valproic Acid; Verapamil | 1995 |
Neurobehavioural dysfunction following mild traumatic brain injury in childhood: a case report with positive findings on positron emission tomography (PET).
Topics: Accidents, Traffic; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain Concussion; Brain Damage, Chronic; Carbamazepine; Child; Child Behavior Disorders; Electroencephalography; Energy Metabolism; Epilepsy, Post-Traumatic; Fluoxetine; Follow-Up Studies; Humans; Male; Mental Recall; Neurocognitive Disorders; Neuropsychological Tests; Temporal Lobe; Tomography, Emission-Computed; Vasodilator Agents; Verapamil; Whiplash Injuries | 1995 |
Effects of the serotonin-1A agonists buspirone and ipsapirone on field potentials in the hippocampus slice: comparison with carbamzepine and verapamil.
Topics: Animals; Buspirone; Carbamazepine; Dose-Response Relationship, Drug; Evoked Potentials; Guinea Pigs; Hippocampus; Magnesium; Pyrimidines; Serotonin Receptor Agonists; Verapamil | 1995 |
Calcium-antagonistic effects of carbamazepine in epilepsies and affective psychoses.
Topics: Animals; Caffeine; Calcium Channel Blockers; Carbamazepine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Mood Disorders; Neurons; Penicillins; Verapamil | 1993 |
[Cluster-tic syndrome: two case reports].
Topics: Adult; Carbamazepine; Cluster Headache; Humans; Male; Prednisone; Syndrome; Trigeminal Neuralgia; Verapamil | 1996 |
Carbamazepine and L-type calcium channel inhibitors: a binding assay study.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Calcium Channel Blockers; Carbamazepine; Diltiazem; In Vitro Techniques; Isradipine; Lithium; Male; Phenethylamines; Rats; Rats, Wistar; Verapamil | 1996 |
Effects of the calcium antagonists verapamil and nitrendipine on carbamazepine withdrawal.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Convulsants; Male; Nitrendipine; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Verapamil | 1999 |
Carbamazepine is not a substrate for P-glycoprotein.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Calcium Channel Blockers; Carbamazepine; Epilepsy; Flow Cytometry; Humans; Lymphocytes; Mice; Mice, Knockout; Verapamil | 2001 |
P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbamazepine; Extracellular Space; Female; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Wistar; Uricosuric Agents; Verapamil | 2001 |
Chronic administration of verapamil, ketoconazole and carbamazepine: impact on immunological parameters.
Topics: Animals; Anticonvulsants; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Cell Count; Body Weight; Calcium Channel Blockers; Carbamazepine; Cytochrome P-450 Enzyme System; Immunity; Immunity, Cellular; Ketoconazole; Male; Mice; Monocytes; Verapamil | 2002 |
The paroxysmal hemicrania-tic syndrome.
Topics: Aged; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fructose; Humans; Indomethacin; Male; Middle Aged; Syndrome; Topiramate; Trigeminal Neuralgia; Vascular Headaches; Verapamil | 2003 |
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil | 2008 |
Resident and fellow section. Expert opinion: trigeminal autonomic cephalgia post transsphenoidal surgery.
Topics: Adenoma; Adrenal Insufficiency; Adult; Analgesics; Anticonvulsants; Carbamazepine; Diabetes Insipidus; Diagnostic Errors; Female; Humans; Magnetic Resonance Imaging; Neurosurgical Procedures; Oxygen Inhalation Therapy; Pituitary Diseases; Pituitary Neoplasms; Sphenoid Sinus; Sumatriptan; Trigeminal Autonomic Cephalalgias; Verapamil | 2008 |
Polymer percolation threshold in HPMC extended release formulation of carbamazepine and verapamil HCl.
Topics: Analgesics, Non-Narcotic; Anti-Arrhythmia Agents; Carbamazepine; Combinatorial Chemistry Techniques; Computer Simulation; Data Interpretation, Statistical; Delayed-Action Preparations; Diffusion; Drug Combinations; Drug Design; Lactose; Methylcellulose; Models, Chemical; Models, Statistical; Polymers; Verapamil | 2010 |
An HPLC-UV method for the measurement of permeability of marker drugs in the Caco-2 cell assay.
Topics: Acyclovir; Caco-2 Cells; Carbamazepine; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Humans; Hydrochlorothiazide; Intestinal Mucosa; Pharmaceutical Preparations; Propranolol; Ultraviolet Rays; Verapamil; Vinblastine | 2011 |
Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties.
Topics: Carbamazepine; Cellulose; Chemistry, Pharmaceutical; Diclofenac; Drug Compounding; Kinetics; Lactose; Particle Size; Polymers; Porosity; Pressure; Solubility; Tablets; Verapamil; Viscosity | 2013 |
P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Disease Models, Animal; Drug Resistance; Epilepsy; Male; Phenytoin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Up-Regulation; Verapamil | 2013 |
Uptake of Pharmaceuticals Influences Plant Development and Affects Nutrient and Hormone Homeostases.
Topics: Biomass; Carbamazepine; Cucurbita; Dose-Response Relationship, Drug; Photosynthesis; Plant Development; Plant Growth Regulators; Plant Leaves; Soil Pollutants; Verapamil | 2015 |
Nanoparticle-based delivery of carbamazepine: A promising approach for the treatment of refractory epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Resistant Epilepsy; Electrocorticography; Isoniazid; Lactic Acid; Male; Nanoparticles; Poloxamer; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Wistar; Verapamil | 2018 |
Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbamazepine; Drug Interactions; Male; Oxcarbazepine; Phenytoin; Rats; Rats, Wistar; Silymarin; Tissue Distribution; Verapamil | 2021 |
An Experimental and Theoretical Study of Laser Postionization of Femtosecond-Laser-Desorbed Drug Molecules.
Topics: Carbamazepine; Ciprofloxacin; Imipramine; Ions; Kinetics; Lasers; Models, Molecular; Molecular Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Verapamil | 2020 |
Chronic Administration of Ion Channel Blockers Impact Microglia Morphology and Function in a Murine Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Carbamazepine; Disease Models, Animal; Ion Channels; Male; Mice; Mice, Transgenic; Microglia; Verapamil | 2023 |