verapamil and bupivacaine

verapamil has been researched along with bupivacaine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.83)18.7374
1990's7 (29.17)18.2507
2000's6 (25.00)29.6817
2010's6 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Brouillette, WJ; Brown, GB; Zha, C1
Artursson, P; Mateus, A; Matsson, P1
Novotny, MV; Riekkola, ML; Soini, H1
Källfelt, B; Lindblom, B; Norén, H2
Rosenblatt, RM; Tallman, RD; Wang, YL; Weaver, JM1
Ahmad, R; Berdeaux, A; Edouard, A; Froidevaux, R; Noviant, Y; Samii, K1
Mastaglia, FL; Steer, JH1
Collier, C1
Attolini, L; Bruguerolle, B; Gantenbein, M; Grignon, S; Jacob, D1
Choe, H; Han, YJ; Kim, DC; Kim, JS; Ko, SH; Song, HS1
Adsan, H; Onaran, O; Tulunay, M1
Ding, Y; Lin, B; Zhu, X1
Gao, XR; Lin, XM; Liu, T; Lü, S1
Bar, J; Bednarz, I; Chwilkowska, A; Drag-Zalesinska, M; Dumanska, M; Gamian, A; Kulbacka, J; Lugowski, M; Marcinkowska, A; Saczko, J; Stach, K; Wysocka, T1
Choi, YS; Hah, YS; Hwang, EM; Jeong, YS; Lee, SH; Ok, SH; Park, JY; Shin, IW; Sohn, JT1
Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M1

Trials

2 trial(s) available for verapamil and bupivacaine

ArticleYear
Epidural verapamil reduces analgesic consumption after lower abdominal surgery.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:4

    Topics: Abdomen; Adult; Affect; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Bupivacaine; Calcium Channel Blockers; Chi-Square Distribution; Consciousness; Double-Blind Method; Follow-Up Studies; Humans; Incidence; Injections, Epidural; Middle Aged; Morphine; Pain, Postoperative; Premedication; Sensation; Sodium Chloride; Spinal Cord; Verapamil

1998
[Verapamil effect and influence on postoperative epidural analgesia and cell factors TNFalpha, IL-6 and IL-2].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2007, Volume: 38, Issue:5

    Topics: Analgesia, Epidural; Analgesics; Anesthesia, Epidural; Bupivacaine; Female; Fentanyl; Humans; Hysterectomy; Injections, Intramuscular; Interleukin-2; Interleukin-6; Pain, Postoperative; Postoperative Period; Tumor Necrosis Factor-alpha; Verapamil

2007

Other Studies

22 other study(ies) available for verapamil and bupivacaine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels

2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Chiral separations of basic drugs and quantitation of bupivacaine enantiomers in serum by capillary electrophoresis with modified cyclodextrin buffers.
    Journal of chromatography, 1992, Sep-11, Volume: 608, Issue:1-2

    Topics: Buffers; Bupivacaine; Cellulose; Cyclodextrins; Detergents; Electrophoresis; Electrophoresis, Polyacrylamide Gel; Fluoxetine; Humans; Mepivacaine; Pharmaceutical Preparations; Stereoisomerism; Verapamil

1992
Effects of bupivacaine and calcium antagonists on human uterine arteries in pregnant and non-pregnant women.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:6

    Topics: Arteries; Bupivacaine; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pregnancy; Uterus; Verapamil

1991
Effects of bupivacaine and calcium antagonists on the rat uterine artery.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:1

    Topics: Animals; Bupivacaine; Calcium Channel Blockers; Female; Nifedipine; Rats; Rats, Inbred Strains; Uterus; Vasoconstriction; Verapamil

1991
Verapamil increases the toxicity of local anesthetics.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:4

    Topics: Animals; Bupivacaine; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Lidocaine; Mice; Verapamil

1988
Bupivacaine accentuates the cardiovascular depressant effects of verapamil in conscious dogs.
    European journal of anaesthesiology, 1987, Volume: 4, Issue:4

    Topics: Animals; Bupivacaine; Calcium Chloride; Dogs; Drug Interactions; Hemodynamics; Infusions, Intravenous; Random Allocation; Verapamil

1987
Protein degradation in bupivacaine-treated muscles. The role of extracellular calcium.
    Journal of the neurological sciences, 1986, Volume: 75, Issue:3

    Topics: Animals; Bupivacaine; Calcium; Female; Muscle Proteins; Muscles; Rats; Rats, Inbred WF; Tyrosine; Verapamil

1986
Verapamil and epidural bupivacaine.
    Anaesthesia and intensive care, 1985, Volume: 13, Issue:1

    Topics: Anesthesia, Epidural; Bupivacaine; Drug Interactions; Humans; Verapamil

1985
Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice.
    Pharmacology, 1996, Volume: 53, Issue:4

    Topics: Anesthetics, Local; Animals; Blood Proteins; Bupivacaine; Calcium Channel Blockers; Diltiazem; Erythrocytes; In Vitro Techniques; Lidocaine; Male; Mice; Nicardipine; Protein Binding; Verapamil

1996
The effects of verapamil and nimodipine on bupivacaine-induced cardiotoxicity in rats: an in vivo and in vitro study.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:4

    Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Calcium Channel Blockers; Confidence Intervals; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Heart; Heart Rate; Incidence; Injections, Intravenous; Lethal Dose 50; Male; Myocardial Contraction; Nimodipine; Premedication; Rats; Rats, Sprague-Dawley; Survival Rate; Verapamil

1998
Study of interaction between drug enantiomers and serum albumin by capillary electrophoresis.
    Electrophoresis, 1999, Volume: 20, Issue:9

    Topics: Binding, Competitive; Bupivacaine; Electrophoresis, Capillary; Ibuprofen; Isomerism; Protein Binding; Serum Albumin; Verapamil; Warfarin

1999
Oxidative modulation of marcaine and lekoptin in H9C2 rat myoblasts.
    Acta pharmacologica Sinica, 2009, Volume: 30, Issue:2

    Topics: Anesthetics, Local; Animals; Apoptosis; Bupivacaine; Calcium Channel Blockers; Cell Line; Ki-67 Antigen; Lipid Peroxidation; Myoblasts; Myocardium; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Verapamil

2009
The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Anesthetics, Local; Animals; Aorta, Thoracic; Benzoquinones; Bupivacaine; Calcium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Levobupivacaine; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Chloride; Quinacrine; Rats; Rats, Sprague-Dawley; Verapamil

2010
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:3

    Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideline Adherence; Health Care Surveys; Humans; Physician Executives; Poison Control Centers; Poisoning; Practice Guidelines as Topic; Remote Consultation; Severity of Illness Index; Shock; Societies, Medical; United States; Verapamil; Xenobiotics

2013