verapamil has been researched along with 2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burk, O; Eichelbaum, M; Fromm, MF; Mettang, T; Pauli-Magnus, C; von Richter, O; Ziegler, A | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Balderston, SM; Johnson, KE; Mann, DE; Pieper, JA; Reiter, MJ | 1 |
| Husum, D; Jensen, G; Johnsen, A | 1 |
| Metelitsa, VI; Nikolenko, SA; Piotrovskii, VK; Riabokon, OS; Rumiantsev, DO | 1 |
| Barbieri, E; Cargnelli, G; Ferrari, M; Padrini, R; Piovan, D; Toffoli, M; Trevi, G | 1 |
| Barbieri, E; Ferrari, M; Motta, A; Padrini, R; Piovan, D; Toffoli, M; Trevi, GP | 1 |
| Akers, WS; Johnson, JA | 1 |
| Abdel-Rahman, MS; Harder, S; Woodcock, BG; Wosch, F | 1 |
| Gonzalez, FJ; Korzekwa, KR; Tracy, TS; Wainer, IW | 1 |
| Borlak, J; Levsen, K; Thum, T; Walles, M | 1 |
| Kümmerer, K; Metzger, JW; Trautwein, C | 1 |
| de Lange, EC; Eriksson, J; Lammertsma, AA; Luurtsema, G; Schuit, RC; Syvänen, S; Verbeek, J; Windhorst, AD | 1 |
1 review(s) available for verapamil and 2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
12 other study(ies) available for verapamil and 2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile
| Article | Year |
|---|---|
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Cardiotonic Agents; Cell Line; Digoxin; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Nitriles; Swine; Verapamil | 2000 |
Electrophysiologic effects of verapamil metabolites in the isolated heart.
Topics: Animals; Atrioventricular Node; Electrophysiology; Female; Heart; Heart Conduction System; Male; Nitriles; Rabbits; Random Allocation; Verapamil | 1991 |
Requirements for drug monitoring of verapamil: experience from an unselected group of patients with cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Biotransformation; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Nitriles; Regression Analysis; Verapamil | 1990 |
Disposition kinetics and urinary excretion of verapamil and some of its primary metabolites after oral administration in patients with angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Biological Availability; Half-Life; Humans; Kinetics; Male; Middle Aged; Nitriles; Regression Analysis; Verapamil | 1986 |
Plasma levels and urinary excretion of verapamil, norverapamil, N-dealkylverapamil (D617), N-dealkylnorverapamil (D620) following oral administration of a slow-release preparation.
Topics: Adult; Cardiac Catheterization; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Nitriles; Plasma; Verapamil | 1985 |
Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coronary Disease; Female; Heart Valve Diseases; Humans; Male; Mathematics; Middle Aged; Models, Biological; Myocardium; Nitriles; Verapamil | 1985 |
Influence of metabolites on protein binding of verapamil enantiomers.
Topics: Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; In Vitro Techniques; Male; Nitriles; Protein Binding; Stereoisomerism; Verapamil | 1995 |
Effect of D,L-verapamil, verapamil enantiomers and verapamil metabolites on the binding of vincristine to alpha 1-acid glycoprotein.
Topics: Nitriles; Orosomucoid; Protein Binding; Verapamil; Vincristine | 1993 |
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
Topics: Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mixed Function Oxygenases; Nitriles; Stereoisomerism; Substrate Specificity; Tumor Cells, Cultured; Verapamil | 1999 |
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
Topics: Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Coronary Vessels; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Endothelium, Vascular; Gene Expression; Humans; Nitriles; Oxidoreductases, N-Demethylating; Recombinant Proteins; Verapamil | 2003 |
Aerobic biodegradability of the calcium channel antagonist verapamil and identification of a microbial dead-end transformation product studied by LC-MS/MS.
Topics: Aerobiosis; Bacteria; Biodegradation, Environmental; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Molecular Structure; Nitriles; Sewage; Tandem Mass Spectrometry; Verapamil | 2008 |
Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Chemistry Techniques, Synthetic; Kinetics; Male; Nitriles; Positron-Emission Tomography; Radiochemistry; Rats; Verapamil | 2012 |