verapamil and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

verapamil has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19906 (11.11)18.7374
1990's38 (70.37)18.2507
2000's6 (11.11)29.6817
2010's4 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chiyotani, A; Isono, K; Kondo, M; Konno, K; Sakai, N; Tamaoki, J1
Nicholson, GC; Papadimitriou, JM; Wood, DJ; Zheng, MH1
Koide, Y; Miyachi, H; Sekiguchi, S; Shibata, T; Takemura, Y; Tukemura, Y1
Jin, N; Packer, CS; Rhoades, RA1
Izawa, T; Komabayashi, T; Rubin, RP; Suda, K; Tsuboi, M; Yakata, A1
Chang, JP; de Leeuw, R; Jobin, RM1
Ganguly, NK; Khullar, M; Khurana, S; Panigrahi, D; Walia, BN1
Davidson, MB; Furman, A; Molnar, IG; Yamaguchi, D1
Martin, DB; Pek, SB; Thomas, TP1
Chen, YM; Kimura, T; Lee, CY; Lee, SY; Lin, WW; Nishio, H; Sakakibara, S1
Aoki, Y; Matsumura, K; Sato, K; Shimada, M1
Iwata, K; Sasaki, Y1
Djeu, JY; Richards, AL1
Russell, JA; Steffan, M1
Chan, SO; Wong, SS; Yeung, DC1
Kurtz, A; Scholz, H1
Kabemura, M; Kimura, G; Matsuzaki, A; Ohtsu, M; Shimura, H1
Bright, EC; Colombani, PM; Hess, AD; Wells, M1
Barile, G; Faggioni, A; Frati, L; Grimaldi, S; Lazdins, J; Venanzoni, M; Zompetta, C1
Dandona, P; Jeremy, JY1
Dandona, P; Morrell, DJ; Preece, MA; Taylor, AM1
Dandona, P; Khokher, MA1
Barber, LE; Lu, M; Renfro, JL1
Blaheta, RA; Encke, A; Hailer, NP; Harder, S; Markus, BH; Scholz, M1
Dreijer, AM; Kits, KS1
Ganguly, NK; Kanwar, RK; Kumar, L; Panigrahi, D; Rakesh, J; Walia, BN1
Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F; Wong, AO1
Chiu, HC; Lu, FJ; Wung, SL; Yang, HL1
Abraham, I; Sampson, KE; Wolf, CL1
Hori, M; Karaki, H; Ozaki, H; Takizawa, S1
Fink-Puches, R; Helige, C; Kerl, H; Smolle, J; Tritthart, HA1
Arizono, K; Brady, FO; Peterson, KL1
Bertrand, N; McCarron, R; Spatz, M; Stanimirovic, DB1
Clark, AH; Garland, CJ1
Cortijo, J; De Diego, A; Esplugues, J; Morcillo, EJ; Perpiñá, M; Villagrasa, V1
Fukura, H; Igarashi, M; Komiya, Y1
Kachar, B; Lacaz-Vieira, F1
Bäcker, A; Fandrey, J; Jelkmann, W; Kramer, HJ; Meyer-Lehnert, H; Vogel, V1
Ganguly, NK; Kaur, T; Singh, S; Verma, M1
Kwak, SH; Lee, SH1
Dhawan, V; Ganguly, NK; Kaur, T; Singh, S1
Ganguly, NK; Gorowara, S; Sapru, S1
Cozza, EN; Lantos, CP; Pecci, A; Romero, DG1
Carpio, LC; Dziak, R1
Boland, R; Buitrago, C; de Boland, AR; Morelli, S1
Kamata, K; Suenaga, H1
Brady, JD; Jezior, JR; McCammon, KA; Miner, AS; Ratz, PH; Rosenstein, DI1
Damaj, MI1
Blishchenko, EY; Ivanov, VT; Karelin, AA; Khachin, DP; Leontiev, KV; Sazonova, OV; Tolmazova, AG1
Nishizawa, S; Zhang, JH1
Aggour, M; Moret, J; Pierot, L1
Bieger, D; Ford, CA; Tabrizchi, R1
Takagi, T; Tomita, S; Tuan, PM; Watanabe, G; Yamaguchi, S1
Carbonetto, S; Tremblay, M; Vezina-Audette, R1

Reviews

2 review(s) available for verapamil and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].
    No shinkei geka. Neurological surgery, 2008, Volume: 36, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Angioplasty, Balloon; Calcium Channel Blockers; Cell Membrane; Combined Modality Therapy; Endothelin-1; Hemoglobins; Humans; Muscle, Smooth, Vascular; Nicardipine; Nitric Oxide; Oxidative Stress; Subarachnoid Hemorrhage; Vasodilator Agents; Vasospasm, Intracranial; Verapamil

2008
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
    Current opinion in critical care, 2010, Volume: 16, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angioplasty, Balloon; Critical Care; Endovascular Procedures; Humans; Intensive Care Units; Milrinone; Nicardipine; Papaverine; Risk Factors; Subarachnoid Hemorrhage; Vasodilator Agents; Vasospasm, Intracranial; Verapamil

2010

Trials

1 trial(s) available for verapamil and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
Potent vasodilatory effect of fasudil on radial artery graft in coronary artery bypass operations.
    The Annals of thoracic surgery, 2014, Volume: 97, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Coronary Artery Bypass; Female; Humans; Male; Nitroglycerin; Papaverine; Radial Artery; Vasodilator Agents; Verapamil

2014

Other Studies

51 other study(ies) available for verapamil and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
Thromboxane A2 mimetic U46619 stimulates ciliary motility of rabbit tracheal epithelial cells.
    Prostaglandins, 1992, Volume: 43, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cilia; Cyclic AMP; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Fatty Acids, Unsaturated; Hydrazines; Isoproterenol; Isoquinolines; Male; Movement; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Thromboxane A2; Trachea; Verapamil

1992
Evidence that protein kinase-A, calcium-calmodulin kinase and cytoskeletal proteins are involved in osteoclast retraction induced by calcitonin.
    Experimental and molecular pathology, 1992, Volume: 57, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Resorption; Calcitonin; Cells, Cultured; Colchicine; Colforsin; Cytoskeletal Proteins; In Vitro Techniques; Isoquinolines; Neomycin; Osteoclasts; Phospholipases A; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Quinacrine; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Verapamil

1992
Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma.
    Cancer letters, 1992, Aug-14, Volume: 65, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Blotting, Northern; Calcimycin; Calmodulin; Cell Line; Egtazic Acid; Genes, MHC Class I; Genes, myc; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Neoplasm; Signal Transduction; Sulfonamides; Tumor Necrosis Factor-alpha; Verapamil

1992
Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Phentolamine; Piperazines; Propranolol; Pulmonary Artery; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Verapamil; Xanthine Oxidase

1991
Protein kinase C-dependent diacylglycerol formation is mediated via Ca2+/calmodulin in parotid cells.
    European journal of pharmacology, 1991, Jul-12, Volume: 207, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Calmodulin; Carbachol; Diglycerides; Isoquinolines; Lanthanum; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Verapamil

1991
Possible involvement of protein kinase C in gonadotropin and growth hormone release from dispersed goldfish pituitary cells.
    General and comparative endocrinology, 1991, Volume: 81, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Diglycerides; Egtazic Acid; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Growth Hormone; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Pituitary Gland; Protein Kinase C; Tetradecanoylphorbol Acetate; Verapamil

1991
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
    Biochimica et biophysica acta, 1991, Oct-21, Volume: 1097, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlorides; Diarrhea; Enterotoxins; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance

1991
Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis.
    Diabetes, 1991, Volume: 40, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Aminoquinolines; Animals; Biological Transport; Cells, Cultured; Cycloheximide; Glucose; Glyburide; Glycogen; Islets of Langerhans; Isoquinolines; Muscles; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Verapamil

1991
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
    Diabetes, 1991, Volume: 40, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil

1991
Cardiovascular effects of two disulfide analogues of sarafotoxin S6b.
    Toxicon : official journal of the International Society on Toxinology, 1990, Volume: 28, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Coronary Circulation; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Hemodynamics; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred ICR; Muscle, Smooth, Vascular; Piperazines; Protein Kinase Inhibitors; Rats; Respiration; Structure-Activity Relationship; Vascular Resistance; Vasoconstriction; Verapamil; Viper Venoms

1990
Praziquantel-induced secretion of proteolytic enzyme from Schistosoma mansoni cercariae.
    The Journal of parasitology, 1990, Volume: 76, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Induction; Isoquinolines; Peptide Hydrolases; Piperazines; Praziquantel; Schistosoma mansoni; Sulfonamides; Verapamil

1990
Concanavalin A- and fetal-calf-serum-induced rounding and myosin light chain phosphorylation in cultured smooth muscle cells.
    Journal of cellular physiology, 1990, Volume: 144, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood; Calcimycin; Calcium; Cells, Cultured; Chickens; Concanavalin A; Culture Media; Cytochalasin B; Cytochalasins; Diltiazem; Egtazic Acid; Gizzard, Avian; Ionomycin; Isoquinolines; Kinetics; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Subfragments; Phosphorylation; Rabbits; Verapamil

1990
Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Nov-01, Volume: 145, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cell Line; Cytotoxicity, Immunologic; Egtazic Acid; Gallic Acid; Immunity, Cellular; Isoquinolines; Killer Cells, Natural; Mice; Piperazines; Protein Kinase C; Sulfonamides; Verapamil

1990
Signal transduction in endothelin-induced contraction of rabbit pulmonary vein.
    Pulmonary pharmacology, 1990, Volume: 3, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelins; In Vitro Techniques; Isoquinolines; Nifedipine; Norepinephrine; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Pulmonary Veins; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Vasoconstrictor Agents; Verapamil

1990
Regulation of Ki-ras expression in Reuber H35 cells.
    European journal of biochemistry, 1990, Nov-13, Volume: 193, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; Diglycerides; DNA Probes; Egtazic Acid; Gene Expression Regulation, Neoplastic; Genes, ras; Glucagon; Isoquinolines; Kinetics; Liver Neoplasms, Experimental; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Verapamil

1990
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil

1990
Induction of DNA synthesis by cholera toxin in the temperature-sensitive cell-cycle mutants of rat 3Y1 fibroblasts at a restrictive temperature.
    Journal of cell science, 1989, Volume: 94 ( Pt 1)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cell Cycle; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Fibroblasts; Isoquinolines; Membrane Proteins; Mutation; Pertussis Toxin; Piperazines; Rats; Sulfonamides; Temperature; Verapamil; Virulence Factors, Bordetella

1989
Drug-drug interaction between cyclosporine and agents affecting calcium-dependent lymphocyte proliferation.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Cells, Cultured; Cyclosporins; Drug Interactions; Humans; Imidazoles; Isoquinolines; Lymphocyte Activation; Piperazines; Protein Kinase C; Sulfonamides; Trifluoperazine; Verapamil

1989
TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.
    International journal of cancer, 1987, Dec-15, Volume: 40, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Calmodulin; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil

1987
Fluoride but not phorbol esters stimulate rat urinary bladder prostanoid synthesis: investigations into the roles of G proteins and protein kinase C.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atropine; Bucladesine; Calcimycin; Carbachol; Fluorides; GTP-Binding Proteins; Isoquinolines; Nifedipine; Phorbol Esters; Piperazines; Prostaglandins; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Urinary Bladder; Verapamil

1987
Insulin like growth factor-I, protein kinase-C, calcium and cyclic AMP: partners in the regulation of chondrocyte mitogenesis and metabolism.
    FEBS letters, 1988, Aug-15, Volume: 236, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcium; Cartilage, Articular; Cells, Cultured; Cyclic AMP; Insulin-Like Growth Factor I; Isoquinolines; Mitosis; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Somatomedins; Swine; Verapamil

1988
The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin.
    Diabetes research (Edinburgh, Scotland), 1988, Volume: 8, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; alpha-Linolenic Acid; Animals; Calcimycin; Calcium; Calmodulin; Cells, Cultured; Insulin; Isoquinolines; Linolenic Acids; Lipids; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Verapamil

1988
Renal transepithelial phosphate secretion: luminal membrane voltage and Ca2+ dependence.
    The American journal of physiology, 1994, Volume: 267, Issue:4 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Charybdotoxin; Electrophysiology; Epithelium; Flounder; In Vitro Techniques; Isoquinolines; Kidney; Kinetics; Mannitol; Membrane Potentials; Models, Biological; Phorbol Esters; Phosphates; Phosphorus Radioisotopes; Piperazines; Potassium Chloride; Protein Kinase C; Scorpion Venoms; Sulfonamides; Terpenes; Thapsigargin; Time Factors; Verapamil

1994
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers.
    Immunobiology, 1994, Volume: 191, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzimidazoles; Calcium Channel Blockers; Calmodulin; Cell Adhesion Molecules; Cells, Cultured; Diltiazem; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Mibefradil; Piperazines; Protein Kinase C; Sulfonamides; Tetrahydronaphthalenes; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Verapamil

1994
Multiple second messenger routes enhance two high-voltage-activated calcium currents in molluscan neuroendocrine cells.
    Neuroscience, 1995, Volume: 64, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Electrophysiology; Isoquinolines; Lymnaea; Neurosecretory Systems; Nifedipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Piperazines; Protein Kinase C; Second Messenger Systems; Thionucleotides; Verapamil

1995
Calcium and protein kinase C play an important role in Campylobacter jejuni-induced changes in Na+ and Cl- transport in rat ileum in vitro.
    Biochimica et biophysica acta, 1995, Apr-24, Volume: 1270, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calmodulin; Campylobacter Infections; Campylobacter jejuni; Chlorides; Cyclic AMP; Dantrolene; Diarrhea; Enzyme Activation; Ileum; In Vitro Techniques; Ion Transport; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Sodium; Tetradecanoylphorbol Acetate; Verapamil

1995
Interactions of cyclic adenosine 3',5'-monophosphate, protein kinase-C, and calcium in dopamine- and gonadotropin-releasing hormone-stimulated growth hormone release in the goldfish.
    Endocrinology, 1994, Volume: 135, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine; Female; Goldfish; Gonadotropin-Releasing Hormone; Growth Hormone; Isoquinolines; Male; Piperazines; Pituitary Gland; Protein Kinase C; Sulfonamides; Verapamil

1994
Humic acid induces expression of tissue factor by cultured endothelial cells: regulation by cytosolic calcium and protein kinase C.
    Thrombosis and haemostasis, 1994, Volume: 71, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cells, Cultured; Endothelium, Vascular; Humans; Humic Substances; Intracellular Fluid; Isoquinolines; Peripheral Vascular Diseases; Piperazines; Protein Kinase C; Taiwan; Thromboplastin; Umbilical Veins; Verapamil; Water Supply

1994
Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.
    Cancer letters, 1993, Jan-15, Volume: 68, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Drug Interactions; Drug Resistance; Gene Expression; Humans; Indole Alkaloids; Isoquinolines; KB Cells; Membrane Glycoproteins; Neoplasm Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Verapamil

1993
Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle.
    European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Cytosol; Isoquinolines; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Rabbits; Rats; Rats, Wistar; Type C Phospholipases; Verapamil

1993
Inhibition of melanoma cell directional migration in vitro via different cellular targets.
    Experimental dermatology, 1993, Volume: 2, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoimidazole Carboxamide; Animals; Calcium Channel Blockers; Cell Division; Cell Movement; Dequalinium; Flunarizine; GTP-Binding Proteins; Isoquinolines; Melanoma, Experimental; Mice; Piperazines; Protein Kinase C; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Verapamil

1993
Inhibitors of Ca2+ channels, calmodulin and protein kinases prevent A23187 and other inductions of metallothionein mRNA in EC3 rat hepatoma cells.
    Life sciences, 1993, Volume: 53, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Gallic Acid; Isoquinolines; Liver Neoplasms, Experimental; Metallothionein; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil

1993
Endothelins release 51Cr from cultured human cerebromicrovascular endothelium.
    Biochemical and biophysical research communications, 1993, Feb-26, Volume: 191, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Chromium Radioisotopes; Dexamethasone; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; L-Lactate Dehydrogenase; Microcirculation; Piperazines; Protein Kinase Inhibitors; Ryanodine; Tetradecanoylphorbol Acetate; Verapamil

1993
Ca2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery.
    European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium Channel Blockers; Carbamates; Female; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Piperazines; Potassium; Protein Kinase C; Rabbits; Serotonin; Type C Phospholipases; Verapamil

1993
Effects of phorbol 12,13-diacetate and its influence on spasmogenic responses in normal and sensitized guinea-pig trachea.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Diuretics; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Serotonin; Trachea; Vasodilator Agents; Verapamil

1995
Signaling pathway downstream of GABAA receptor in the growth cone.
    Journal of neurochemistry, 1996, Volume: 67, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Axons; Binding Sites; Calcium; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; GTPase-Activating Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Models, Neurological; Muscimol; Myristoylated Alanine-Rich C Kinase Substrate; Neurites; Picrotoxin; Prosencephalon; Proteins; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction; Verapamil

1996
Tight junction dynamics in the frog urinary bladder.
    Cell adhesion and communication, 1996, Volume: 4, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Barium Sulfate; Cadherins; Cadmium; Calcium; Calcium Channel Blockers; Cell Polarity; Diglycerides; Enzyme Inhibitors; Freeze Fracturing; Magnesium; Nifedipine; Osmotic Pressure; Patch-Clamp Techniques; Protein Kinase C; Rana catesbeiana; Signal Transduction; Tight Junctions; Urinary Bladder; Verapamil

1996
Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells.
    American journal of hypertension, 1997, Volume: 10, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Erythropoietin; Gallic Acid; Genistein; Ionophores; Isoflavones; Muscle, Smooth, Vascular; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Second Messenger Systems; Swine; Verapamil

1997
Calcium and protein kinase C play a significant role in response to Shigella toxin in rabbit ileum both in vivo and in vitro.
    Biochimica et biophysica acta, 1997, Jul-10, Volume: 1361, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bacterial Toxins; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Electrolytes; Ileum; Indomethacin; Inositol Phosphates; Male; Neutralization Tests; Prostaglandins E; Protein Kinase C; Rabbits; Shiga Toxins; Tetradecanoylphorbol Acetate; Verapamil

1997
The requirements for Ca2+, protein phosphorylation, and dephosphorylation for ethylene signal transduction in Pisum sativum L.
    Plant & cell physiology, 1997, Volume: 38, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cyclin-Dependent Kinases; Egtazic Acid; Enzyme Inhibitors; Ethylenes; Phosphoprotein Phosphatases; Phosphorylation; Pisum sativum; Plant Proteins; Protein Kinase C; Signal Transduction; Verapamil

1997
Shigella dysenteriae type 1 toxin induced lipid peroxidation in enterocytes isolated from rabbit ileum.
    Molecular and cellular biochemistry, 1998, Volume: 178, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Bacterial Toxins; Calcimycin; Calcium Channel Blockers; Dantrolene; Dysentery, Bacillary; Enterotoxins; Enzyme Inhibitors; Ileum; In Vitro Techniques; Indomethacin; Ionophores; Lipid Peroxides; Male; Muscle Relaxants, Central; Rabbits; Reactive Oxygen Species; Shiga Toxins; Shigella dysenteriae; Tetradecanoylphorbol Acetate; Verapamil

1998
Role of intracellular second messengers and reactive oxygen species in the pathophysiology of V. cholera O139 treated rabbit ileum.
    Biochimica et biophysica acta, 1998, Jul-01, Volume: 1407, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Calcimycin; Calcium; Calcium Channel Blockers; Cholera; Cyclic AMP; Dantrolene; Enzyme Activation; Ileum; Inositol Phosphates; Ionophores; Lipid Peroxidation; Protein Kinase C; Rabbits; Reactive Oxygen Species; Second Messenger Systems; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance

1998
Mechanisms of action of endothelin-1 in rat adrenal.
    Life sciences, 1998, Volume: 63, Issue:15

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Calcium; Calcium Channels; Cattle; Cells, Cultured; Cholesterol; Diglycerides; Endothelin-1; Male; Ouabain; Peptides, Cyclic; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sodium-Potassium-Exchanging ATPase; Verapamil; Viper Venoms; Zona Glomerulosa

1998
Phosphatidic acid effects on cytosolic calcium and proliferation in osteoblastic cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 59, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Division; Cells, Cultured; Cytoplasm; Epidermal Growth Factor; Osteoblasts; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Rats; Rats, Sprague-Dawley; Skull; Sphingosine; Thapsigargin; Verapamil

1998
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
    Molecular and cellular endocrinology, 2001, Feb-28, Volume: 173, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil

2001
Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: role of protein kinase C.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2000, Volume: 36, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Signaling; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Verapamil

2000
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isoquinolines; Muscle Contraction; Myosin Light Chains; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Time Factors; Urinary Bladder; Verapamil

2001
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil

2005
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.
    The FEBS journal, 2007, Volume: 274, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Chelating Agents; Chlorocebus aethiops; Endorphins; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Isoquinolines; MAP Kinase Signaling System; Mice; Nifedipine; Protein Kinase Inhibitors; Sulfonamides; Verapamil

2007
Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2011, Volume: 47, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Barium; Indoles; Male; Mibefradil; Nicardipine; Niflumic Acid; Potassium; Potassium Channels; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Verapamil

2011
Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
    Matrix biology : journal of the International Society for Matrix Biology, 2017, Volume: 57-58

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Agrin; Animals; Benzoquinones; Bungarotoxins; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cell Line; Gene Expression; Lactams, Macrocyclic; Laminin; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Protein Aggregates; Receptors, Cholinergic; Sodium Channel Blockers; Sodium Channels; Staining and Labeling; Tetrodotoxin; Verapamil

2017