velnacrine and tacrine

velnacrine has been researched along with tacrine in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19907 (12.96)18.7374
1990's35 (64.81)18.2507
2000's10 (18.52)29.6817
2010's2 (3.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bores, GM; Cornfeldt, ML; Davis, KL; Haroutunian, V; Huger, FP; Kapples, KJ; Pierrat, FA; Shutske, GM; Szewczak, MR1
Caprathe, BW; Emmerling, MR; Jaen, JC; Pool, WF; Reily, MD; Woolf, TF1
Butterfield, DA; Rangachari, A1
Curran, SM; Dougal, NJ; Ebmeier, KP; Goodwin, GM; Hanson, MT; Hunter, R; Murray, CL; Patterson, J; Siegfried, K; Wyper, DJ1
Cutler, NR; Murphy, MF; Nash, RJ; Sramek, JJ1
Badia, A; Baños, JE; Bosch, F; Morales, M2
Braga, MF; Harvey, AL; Rowan, EG1
Deptula, D; Pomara, N; Singh, R1
Demkovich, JJ; Dobson, C; Hardiman, ST; Huff, FJ; Knappe, UE; Murphy, MF; Nash, RJ1
Jertz, G; Murphy, M; Pinker, S; Siegfried, K; Simpson, PM; Wesnes, KA; White, L1
Ford, JM; Roberts, CJ; Truman, CA1
Ho, I; Hsu, R; Lassman, HB; Puri, SK1
Cutler, NR; De Luna, DM; Murphy, MF; Nash, RJ; Prior, PL1
Irie, T; Katsube, J; Natori, K; Okazaki, Y2
Chesson, SM; DiLeo, EM; Ellis, DB; Hsu, RS; Wichmann, JK1
Ekman, L; Lindström, B; Roxin, P1
Ho, I; Hsu, RS; Lassman, HB; Puri, SK2
Hayashi, S; Sakurai, M; Tanaka, Y1
Bores, GM; Cornfeldt, ML; Davis, KL; Haroutunian, V; Huger, FP; Pierrat, FA; Shutske, GM; Szewczak, MR1
Buccafusco, JJ; Jackson, WJ; Rush, DK; Terry, AV; Turk, DJ1
Clipp, EC; Moore, MJ2
Antuono, PG1
Acosta, D; al Casey, S; Brewster, D; Viau, C1
Schehr, RS1
Balogh, L; Brown, RR; Collis, MS; Haughey, DB; Klockowski, PM; McNaney, CA; Siedlik, PH1
Siegfried, KR1
Hardiman, S; Miller, K; Murphy, M1
Beermann, B1
Butterfield, DA; Carney, J; Hall, N; Hensley, K; Umhauer, S1
Curren, RD; Viau, CJ; Wallace, K1
Cutler, NR; Sramek, JJ2
Keys, M; Richter, RW; Strub, RL; Zemlan, FP1
Citrome, L; Pomara, N1
Ford, JM; Roberts, CJ; Wood, DM1
Duoyon, E; Lee, WS; Morrishow, AM; Prell, GD1
Zemlan, FP1
Laine, K; Manninen, P; Palovaara, S; Tapanainen, P1
Aparicio, I; Bello, MA; Callejón, M; Guiraúm, A; Jiménez, JC2
Cecchetti, V; Filipponi, E; Fravolini, A; Lamperti, MG; Tabarrini, O; Temperini, A1
Birks, J; Wilcock, GG1
Ahn, SH; Chung, SJ; Hong, SS; Li, H; Park, BS; Park, CH; Seo, SY; Sung, JH1
Martins e Silva, J; Saldanha, C; Silva, AS1
Almeida, JP; Carvalho, FA; Freitas, T; Saldanha, C1
Almeida, JP; Carvalho, FA; Fernandes, IO; Freitas-Santos, T; Saldanha, C1
Carvalho, FA; Lopes de Almeida, JP; Saldanha, C; Santos-Freitas, T; Silva-Herdade, AS1
Carvalho, FA; de Almeida, JP; Freitas-Santos, T; Saldanha, C1
Qian, S; Wo, SK; Zuo, Z1
Saldanha, C; Silva-Herdade, AS1

Reviews

3 review(s) available for velnacrine and tacrine

ArticleYear
Pharmacodynamic and early clinical studies with velnacrine.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Placebos; Scopolamine; Tacrine; Tomography, Emission-Computed, Single-Photon

1993
Side effects of long acting cholinesterase inhibitors.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149

    Topics: Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Clinical Trials as Topic; Female; Humans; Liver; Male; Tacrine; Transaminases

1993
Velnacrine for Alzheimer's disease.
    The Cochrane database of systematic reviews, 2004, Issue:2

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Randomized Controlled Trials as Topic; Tacrine

2004

Trials

18 trial(s) available for velnacrine and tacrine

ArticleYear
Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: Aged; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Physostigmine; Tacrine; Tomography, Emission-Computed, Single-Photon

1992
Implications of the study population in the early evaluation of anticholinesterase inhibitors for Alzheimer's disease.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:9

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Double-Blind Method; Drug Administration Schedule; Humans; Male; Middle Aged; Tacrine

1992
Pretreatment postural blood pressure drop as a possible predictor of response to the cholinesterase inhibitor velnacrine (HP 029) in Alzheimer's disease.
    Psychopharmacology bulletin, 1991, Volume: 27, Issue:3

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Double-Blind Method; Female; Humans; Hypotension, Orthostatic; Male; Supine Position; Tacrine

1991
Evaluation of HP 029 (velnacrine maleate) in Alzheimer's disease.
    Annals of the New York Academy of Sciences, 1991, Volume: 640

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Drug Evaluation; Female; Humans; Male; Middle Aged; Placebos; Psychological Tests; Tacrine

1991
Multiple dose pharmacokinetics, safety, and tolerance of velnacrine (HP 029) in healthy elderly subjects: a potential therapeutic agent for Alzheimer's disease.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:10

    Topics: Administration, Oral; Aged; Alzheimer Disease; Drug Administration Schedule; Drug Evaluation; Half-Life; Humans; Male; Middle Aged; Risk Factors; Tacrine; Time Factors

1990
Clinical safety, tolerance, and plasma levels of the oral anticholinesterase 1,2,3,4-tetrahydro-9-aminoacridin-1-oL-maleate (HP 029) in Alzheimer's disease: preliminary findings.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:6

    Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Middle Aged; Random Allocation; Risk Factors; Tacrine; Time Factors

1990
The effect of food on the bioavailability of velnacrine (HP 029) in healthy elderly men: a potential Alzheimer agent.
    Journal of clinical pharmacology, 1989, Volume: 29, Issue:10

    Topics: Aged; Alzheimer Disease; Aminoacridines; Biological Availability; Chromatography, High Pressure Liquid; Electrocardiography; Food; Humans; Intestinal Absorption; Male; Middle Aged; Tacrine

1989
Single dose safety, tolerance, and pharmacokinetics of HP 029 in healthy young men: a potential Alzheimer agent.
    Journal of clinical pharmacology, 1989, Volume: 29, Issue:3

    Topics: Adult; Alzheimer Disease; Aminoacridines; Double-Blind Method; Drug Evaluation; Drug Tolerance; Humans; Male; Random Allocation; Risk Factors; Tacrine

1989
Caregiver time use: an outcome measure in clinical trial research on Alzheimer's disease.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cognition; Double-Blind Method; Female; Humans; Male; Middle Aged; Severity of Illness Index; Tacrine; Time; Treatment Outcome

1995
Effectiveness and safety of velnacrine for the treatment of Alzheimer's disease. A double-blind, placebo-controlled study. Mentane Study Group.
    Archives of internal medicine, 1995, Sep-11, Volume: 155, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Tacrine; Treatment Outcome

1995
Alzheimer's disease and caregiver time.
    Lancet (London, England), 1994, Jan-22, Volume: 343, Issue:8891

    Topics: Activities of Daily Living; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Double-Blind Method; Humans; Single-Blind Method; Tacrine; Time Factors; Workload

1994
Pharmacodynamic and early clinical studies with velnacrine.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Placebos; Scopolamine; Tacrine; Tomography, Emission-Computed, Single-Photon

1993
Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149

    Topics: Age Factors; Aged; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Enzyme Activation; Female; Humans; Liver; Liver Diseases; Male; Models, Statistical; Probability; Sex Factors; Tacrine

1993
The target population in phase I clinical trials of cholinergic compounds in Alzheimer disease: the role of the "bridging study".
    Alzheimer disease and associated disorders, 1995,Fall, Volume: 9, Issue:3

    Topics: Alzheimer Disease; Cholinergic Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Physostigmine; Safety; Tacrine

1995
Double-blind placebo-controlled study of velnacrine in Alzheimer's disease.
    Life sciences, 1996, Volume: 58, Issue:21

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos; Tacrine

1996
Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride). A potential agent for Alzheimer's disease.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Binding, Competitive; Blood Proteins; Cholinesterase Inhibitors; Female; Humans; Male; Orosomucoid; Protein Binding; Serum Albumin; Tacrine

1996
Velnacrine for the treatment of Alzheimer's disease: a double-blind, placebo-controlled trial. The Mentane Study Group.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:8-9

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Placebos; Tacrine; Treatment Outcome

1996
Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:6

    Topics: Adult; Cholinesterase Inhibitors; Cross-Over Studies; Cytochrome P-450 CYP1A2; Double-Blind Method; Estradiol; Estrogen Replacement Therapy; Female; Humans; Hydroxylation; Levonorgestrel; Nootropic Agents; Progesterone Congeners; Reference Values; Tacrine

1999

Other Studies

34 other study(ies) available for velnacrine and tacrine

ArticleYear
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Alzheimer Disease; Aminoacridines; Animals; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Male; Memory; Mice; Rats; Rats, Inbred Strains; Scopolamine; Structure-Activity Relationship; Tacrine

1989
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.
    Journal of medicinal chemistry, 1996, Jul-19, Volume: 39, Issue:15

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Structure; Rats; Tacrine

1996
Membrane-altering effects of velnacrine and N-methylacridinium: relevance to tacrine and Alzheimer's disease.
    Biochemical and biophysical research communications, 1992, Jun-15, Volume: 185, Issue:2

    Topics: Acridines; Alzheimer Disease; Cytoskeletal Proteins; Cytoskeleton; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; In Vitro Techniques; Protein Binding; Structure-Activity Relationship; Tacrine

1992
Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction.
    European journal of pharmacology, 1992, Nov-03, Volume: 222, Issue:1

    Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine

1992
Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and 3,4-diaminopyridine on skeletal neuromuscular transmission in vitro.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: 4-Aminopyridine; Acetylcholine; Acetylcholinesterase; Action Potentials; Amifampridine; Aminoacridines; Animals; Calcium; Chick Embryo; Cholinesterase Inhibitors; Electrophysiology; In Vitro Techniques; Magnesium; Male; Mice; Mice, Inbred BALB C; Motor Endplate; Neuromuscular Junction; Respiratory Muscles; Synaptic Transmission; Tacrine

1991
Cholinesterase inhibition in the scopolamine model of dementia.
    Annals of the New York Academy of Sciences, 1991, Volume: 640

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Memory; Scopolamine; Tacrine

1991
Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes.
    Biochemical pharmacology, 1991, Jul-25, Volume: 42, Issue:4

    Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humans; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Tacrine

1991
Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:2

    Topics: Aminacrine; Aminoacridines; Aminoquinolines; Animals; Body Temperature; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Nucleic Acids; Physostigmine; Rats; Salivation; Tacrine

1990
Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:2

    Topics: Aminacrine; Aminoacridines; Aminoquinolines; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cycloheximide; Electroshock; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Physostigmine; Tacrine

1990
Determination of velnacrine in plasma and urine by high-performance liquid chromatography.
    Journal of chromatography, 1989, Sep-29, Volume: 494

    Topics: Aminoacridines; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humans; Tacrine

1989
Determination of tacrine and its 1-hydroxy metabolite in plasma using column liquid chromatography with ultraviolet detection.
    Journal of chromatography, 1989, Sep-29, Volume: 494

    Topics: Aminoacridines; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humans; Spectrophotometry, Ultraviolet; Tacrine

1989
Effect of scopolamine and HP 029, a cholinesterase inhibitor, on long-term potentiation in hippocampal slices of the guinea pig.
    Neuroscience letters, 1989, Mar-27, Volume: 98, Issue:2

    Topics: Action Potentials; Aminoacridines; Animals; Cholinergic Fibers; Cholinesterase Inhibitors; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Scopolamine; Tacrine; Time Factors

1989
(+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Alzheimer Disease; Aminoacridines; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Humans; Mice; Rats; Tacrine

1988
Velnacrine maleate improves delayed matching performance by aged monkeys.
    Psychopharmacology, 1995, Volume: 119, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Maleates; Memory; Tacrine; Time Factors

1995
Effect of glutathione depletion and oxidative stress on the in vitro cytotoxicity of velnacrine maleate.
    Toxicology letters, 1995, Volume: 76, Issue:3

    Topics: Alzheimer Disease; Animals; Cells, Cultured; Cholinesterase Inhibitors; Fluorescent Dyes; Formazans; Glutathione; L-Lactate Dehydrogenase; Liver; Neutral Red; Oxidation-Reduction; Oxidative Stress; Peroxides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tacrine; tert-Butylhydroperoxide; Tetrazolium Salts

1995
Therapeutic approaches to Alzheimer's disease. An informal survey of promising drug discovery strategies.
    Bio/technology (Nature Publishing Company), 1994, Volume: 12, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Drug Design; Humans; Neurotransmitter Agents; Tacrine

1994
Simultaneous determination of tacrine and 1-hydroxy-, 2-hydroxy-, and 4-hydroxytacrine in human plasma by high-performance liquid chromatography with fluorescence detection.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:11

    Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humans; Quality Control; Spectrometry, Fluorescence; Tacrine

1994
Interaction of tacrine and velnacrine with neocortical synaptosomal membranes: relevance to Alzheimer's disease.
    Neurochemical research, 1993, Volume: 18, Issue:9

    Topics: Alzheimer Disease; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Cytoskeletal Proteins; Electron Spin Resonance Spectroscopy; Gerbillinae; Male; Rats; Rats, Sprague-Dawley; Synaptic Membranes; Synaptosomes; Tacrine

1993
Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation.
    General pharmacology, 1993, Volume: 24, Issue:5

    Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Blocking Agents; Neuromuscular Junction; Phrenic Nerve; Physostigmine; Rats; Rats, Sprague-Dawley; Respiratory Muscles; Tacrine

1993
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
    Drug and chemical toxicology, 1993, Volume: 16, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Dogs; Female; Humans; L-Lactate Dehydrogenase; Liver; Liver Diseases; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Sensitivity and Specificity; Tacrine; Tumor Cells, Cultured

1993
Scientific and ethical concerns in clinical trials in Alzheimer's patients: the bridging study.
    European journal of clinical pharmacology, 1995, Volume: 48, Issue:6

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Dihydropyridines; Ethics, Medical; Humans; Nootropic Agents; Oximes; Physostigmine; Psychotropic Drugs; Pyridines; Tacrine; Thiadiazoles

1995
Transient elevations in pancreatic enzymes in response to a cholinesterase inhibitor.
    Clinical neuropharmacology, 1995, Volume: 18, Issue:5

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Male; Middle Aged; Pancreas; Tacrine

1995
Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors.
    Journal of neurochemistry, 1997, Volume: 68, Issue:1

    Topics: Animals; Brain; Gas Chromatography-Mass Spectrometry; Histamine; Imidazoles; Male; Methylation; Physostigmine; Pyrimethamine; Rats; Rats, Sprague-Dawley; Receptors, GABA; Tacrine

1997
Electrochemical oxidation at carbon paste electrode of tacrine and 1-hydroxytacrine and differential pulse voltammetric determination of tacrine in pharmaceuticals and human urine.
    The Analyst, 2000, Volume: 125, Issue:11

    Topics: Carbon; Electrochemistry; Electrodes; Humans; Tacrine

2000
Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:11

    Topics: Administration, Oral; Alzheimer Disease; Animals; Avoidance Learning; Blood Cells; Chlorine; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Models, Molecular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfur; Survival Rate; Tacrine

2001
Spectrofluorimetric determination of velnacrine in human serum and urine.
    Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:12

    Topics: Humans; Spectrometry, Gamma; Tacrine

2003
Mechanism for increased bioavailability of tacrine in fasted rats.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:5

    Topics: Administration, Oral; Animals; Biological Availability; Cholinesterase Inhibitors; Fasting; Injections, Intravenous; Intestinal Absorption; Male; Permeability; Rats; Rats, Sprague-Dawley; Tacrine

2006
Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network.
    Clinical hemorheology and microcirculation, 2007, Volume: 36, Issue:3

    Topics: Acetylcholine; Alzheimer Disease; Animals; Blood Pressure; Cholinesterase Inhibitors; Endothelium, Vascular; Interleukin-1beta; Leukocyte Rolling; Leukocytes; Male; Microcirculation; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Scrotum; Tacrine; Venules

2007
Modulation of hemorheological parameters by the erythrocyte redox thiol status.
    Clinical hemorheology and microcirculation, 2008, Volume: 40, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Cholinergic Agents; Cholinesterase Inhibitors; Dithiothreitol; Erythrocyte Aggregation; Erythrocyte Deformability; Erythrocytes; Hematologic Diseases; Humans; Male; Membrane Fluidity; Microcirculation; Oxidation-Reduction; Tacrine

2008
Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells.
    Clinical hemorheology and microcirculation, 2008, Volume: 40, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Anion Exchange Protein 1, Erythrocyte; Cholinesterase Inhibitors; Erythrocytes; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Intracellular Signaling Peptides and Proteins; Nitric Oxide; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-hck; Signal Transduction; src-Family Kinases; Syk Kinase; Tacrine

2008
Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells.
    Cell biology international, 2009, Volume: 33, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Cholinesterase Inhibitors; Dithiothreitol; Erythrocytes; Humans; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; S-Nitrosoglutathione; Tacrine

2009
Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions.
    The Journal of membrane biology, 2009, Volume: 228, Issue:2

    Topics: Acetylcholinesterase; Anion Exchange Protein 1, Erythrocyte; Blotting, Western; Dipeptides; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; GTP-Binding Protein alpha Subunits; GTP-Binding Protein beta Subunits; GTP-Binding Proteins; Humans; Immunoprecipitation; Male; Protein Binding; Tacrine

2009
Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats.
    Journal of pharmaceutical and biomedical analysis, 2012, Mar-05, Volume: 61

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Tacrine

2012
Effects of acetylcholine on an animal mode of inflammation.
    Clinical hemorheology and microcirculation, 2013, Volume: 53, Issue:1-2

    Topics: Acetylcholine; Animals; Cell Movement; Cholinesterase Inhibitors; Endothelium, Vascular; Inflammation; Leukocytes; Lipopolysaccharides; Male; Microscopy; Rats; Rats, Wistar; Tacrine; Tumor Necrosis Factor-alpha

2013