vasoactive-intestinal-peptide and stearic-acid

vasoactive-intestinal-peptide has been researched along with stearic-acid* in 1 studies

Other Studies

1 other study(ies) available for vasoactive-intestinal-peptide and stearic-acid

ArticleYear
A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model.
    The Journal of clinical investigation, 1992, Volume: 90, Issue:3

    Vasoactive intestinal peptide (VIP), a key penile neurotransmitter, induces erection after local injection in man. To augment the therapeutic potential of VIP for impotence treatment and circumvent difficulties of direct penile injections, a strategy was designed to increase peptide hydrophobicity. This was accomplished by the synthesis of a conjugate of VIP and stearic acid (stearyl-VIP). Upon penile topical application, stearyl-VIP, in contrast to native VIP, significantly increased sexual function as measured by copulatory activity and penile reflexes (erections) in testosterone-treated, castrated rats. In addition, stearyl-VIP penetrated the body in amounts severalfold greater than VIP. Pharmacokinetic studies demonstrated 10-fold higher penile concentrations of stearyl-VIP, as compared with that measured in the blood 15 min after application, with a gradual decrease thereafter. The peak of incorporation into peripheral tissues that was observed 30 min after administration was 1,000-fold less than that found in the penile tissue. Tissue extraction and chromatographic analysis revealed that stearyl-VIP remained essentially intact for greater than or equal to 15 min and was cleared after 1 h. Thus, topically administered stearyl-VIP had increased bioavailability in comparison with VIP without apparent toxicity, suggesting significant therapeutic potential.

    Topics: Animals; Disease Models, Animal; Erectile Dysfunction; Male; Penile Erection; Rats; Sexual Behavior, Animal; Stearic Acids; Vasoactive Intestinal Peptide

1992