Compounds > vancomycin
Page last updated: 2024-08-21

vancomycin and ly-146032

vancomycin has been researched along with ly-146032 in 81 studies

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's49 (60.49)29.6817
2010's32 (39.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Appelbaum, PC; Bhawsar, SB; Bozdogan, B; de Souza, NJ; Desai, VN; Deshpande, PK; Gupte, SV; Hooper, DC; Jacobs, MR; Jha, R; Khorakiwala, HF; Patel, MV; Shetty, N; Shukla, MC; Strahilevitz, J; Yeole, RD1
Frank, KL; Patel, R; Piper, KE; Reichert, EJ1
Cheung, CM; Chin, JN; Rybak, MJ; Savage, PB1
Hsueh, PR; Huang, YT; Liao, CH; Teng, LJ1
Baltch, AL; Bopp, LH; Michelsen, PB; Ritz, WJ; Smith, RP1
Alder, JD; Li, T; Mortin, LI; Van Praagh, AD; Zhang, S; Zhang, XX1
Chaiban, G; Dvorak, T; Hachem, R; Hanna, H; Jiang, Y; Raad, I; Reitzel, R; Sherertz, R1
Cottagnoud, M; Cottagnoud, P; Schaffner, T; Stucki, A; Winkelmann, V1
Eliopoulos, GM; Gold, HS; Moellering, RC; Pillai, SK; Sakoulas, G; Wennersten, C1
Cheung, A; Götz, F; Herbert, S; Meehl, M1
Jansen, WT; Milatovic, D; Verel, A; Verhoef, J1
Appelbaum, PC; Bogdanovich, T; Clark, C; Dewasse, B; Kosowska-Shick, K; McGhee, P1
Alder, JD; Mascio, CT; Silverman, JA1
Barriere, SL; Benton, BM; Goldberg, MR; Gotfried, MH; Kitt, MM; Krause, KM; Shaw, JP1
Bayer, AS; Jones, T; Proctor, RA; Sahl, HG; Sakoulas, G; Schrenzel, J; Xiong, YQ; Yang, SJ; Yeaman, MR1
Cui, L; Hiramatsu, K; Matsuo, M; Neoh, HM; Takeuchi, F; Yuzawa, H1
Carpenter, CF; Kaatz, GW; Leonard, SN; Rose, WE; Rybak, MJ; Sakoulas, G; Sheth, A; Zervos, MJ1
Clark, NC; Hageman, J; McDonald, LC; McDougal, LK; Patel, JB; Zhu, W1
Montero, CI; Murray, PR; Stock, F1
Fritsche, TR; Jones, RN; Sader, HS1
Baudry, PJ; DeCorby, M; Hoban, DJ; Johnson, J; Karlowsky, JA; Lagacé-Wiens, P; Laing, N; McCracken, M; Mulvey, MR; Nichol, KA; Tailor, F; Vashisht, R; Walkty, A; Weshnoweski, B; Wierzbowski, A; Zhanel, GG1
Baltch, AL; Bopp, LH; Michelsen, P; Ritz, WJ; Smith, RP1
Chang, KY; Ho, YH; Hsieh, YC; Hsueh, PR; Huang, LM; Huang, YC; Lin, HC1
Almela, M; Amat, E; Armero, Y; de la Mària, CG; del Río, A; Gatell, JM; Jiménez de Anta, MT; Marco, F; Mestres, CA; Miró, JM; Moreno, A; Soy, D1
Lombardo, F; Obach, RS; Waters, NJ1
Benton, BM; Draghi, DC; Krause, KM; Pillar, C; Sahm, DF; Thornsberry, C1
Benton, BM; Debabov, DV; Difuntorum, S; Krause, KM; Renelli, M; Wu, TX1
Cheung, CM; Leonard, SN; Rybak, MJ1
Biek, D; Ge, Y; Sahm, DF; Talbot, GH1
del Pozo, JL; Mandrekar, JN; Patel, R; Rouse, MS; Sampedro, MF; Steckelberg, JM1
Camargo, IL; Cui, L; Hiramatsu, K; Neoh, HM1
Arhin, FF; Belley, A; Beveridge, T; Harris, R; McKay, G; Moeck, G; Neesham-Grenon, E; Parr, TR1
Cui, L; Hiramatsu, K; Neoh, HM; Shoji, M1
Denis, O; Nguyen, HA; Struelens, MJ; Theunis, A; Tulkens, PM; Van Bambeke, F; Vergison, A1
Brown, SD; Katz, BD; Steenbergen, JN; Traczewski, MM1
Daily, SJ; Smeltzer, MS; Spencer, HJ; Weiss, BD; Weiss, EC1
Bayer, AS; Mishra, NN; Nast, CC; Rubio, A; Sawa, A; Yang, SJ; Yeaman, MR1
Arhin, FF; Beaulieu, S; McKay, GA; Moeck, G; Parr, TR; Sarmiento, I1
Jones, RN; Rhomberg, PR; Sader, HS1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Cui, L; Hiramatsu, K; Katayama, Y; Murakami-Kuroda, H1
Benton, BM; Hartouni, SR; Humphrey, PP; Janc, JW; Lunde, CS; Mammen, M1
Chen, H; Chen, M; Liu, Y; Ma, Y; Nichols, WW; Sun, W; Wang, H; Zhang, J; Zhao, C1
Bolanos, M; Finegold, SM; Molitoris, DR; Sumannen, PH1
Bavari, S; Bowlin, T; Butler, MM; Gussio, R; Houseweart, C; Lane, D; Moir, DT; Nguyen, T; Opperman, T; Panchal, RG; Peet, NP; Ulrich, RL; Williams, JD1
Ariza, J; Cabellos, C; Cabo, J; Euba, G; Garrigós, C; Gudiol, F; Murillo, O; Pachón, ME; Verdaguer, R1
Arhin, FF; Draghi, DC; Moeck, G; Parr, TR; Pillar, CM; Sahm, DF1
Bowker, KE; Caspers, P; Gaucher, B; MacGowan, AP1
Bonafede, M; Evans, A; Ferro, S; Harrington, S; Lodise, TP; Lubanski, P; Patel, N; Stellrecht, K1
Basuino, L; Bauer, D; Chambers, HF; Diep, BA; Tattevin, P1
Alexander, DC; Baltz, RH; Brian, P; Chu, M; Gu, JQ; He, X; Li, C; Mascio, C; Mortin, L; Nguyen, KT; Silverman, JA; Van Praagh, A1
Betriu, C; Culebras, E; Gómez, M; López-Fabal, F; Morales, G; Picazo, JJ; Rodríguez-Avial, I1
Janechek, MJ; Jones, RN; Mendes, RE; Moet, GJ1
Johnson, L; Pawlak, J; Saravolatz, L1
Almela, M; Armero, Y; Cervera, C; del Río, A; Falces, C; García-de-la-Mària, C; Gatell, JM; Jiménez de Anta, MT; Marco, F; Mestres, CA; Miró, JM; Moreno, A; Ninot, S; Soy, D1
Bayer, AS; Fey, PD; Mishra, NN; Nast, CC; Yang, SJ; Yeaman, MR1
Chen, FJ; Huang, IW; Lauderdale, TL; Lee, CH; Wang, MC1
Cheung, CM; Leuthner, KD; Rybak, MJ; Vidaillac, C1
Bavari, S; Bowlin, TL; Butler, MM; Moir, DT; Panchal, RG; Peet, NP; Shinabarger, DL; Williams, JD1
Graninger, W; Hajdu, S; Hirschl, AM; Holinka, J; Presterl, E; Reichmann, S1
Parra-Ruiz, J; Rose, WE; Rybak, MJ; Vidaillac, C1
Camargo, IL; Cui, L; Fukuda, M; Hiramatsu, K; Hishinuma, T; Isii, T; Neoh, HM; Ochiai, T; Shoji, M; Watanabe, Y1
Crandon, JL; Kuti, JL; Nicolau, DP1
Benadda, S; Chau, F; Dubée, V; Fantin, B; Lefort, A1
Barnes, MH; Brown, NC; Butler, MM; Dvoskin, S; Gambino, JJ; Long, ZY; Wright, GE; Xu, WC; Zhi, CX1
Kang, H; Kim, H; Nam, SJ; Rho, BJ; Wang, W1
Aung, TT; Beuerman, RW; Cao, D; Chan, HS; Dai, X; Koh, JJ; Lakshminarayanan, R; Li, J; Lim, FH; Lin, H; Liu, S; Qiu, S; Saraswathi, P; Tan, AL; Tan, DT; Tang, C; Verma, C; Zhou, L; Zou, H1
Aung, TT; Bai, Y; Beuerman, RW; Cao, D; Koh, JJ; Koh, WL; Lakshminarayanan, R; Li, J; Lim, F; Lin, H; Lin, S; Liu, S; Pang, LM; Pervushin, K; Qiu, S; Salleh, SM; Tan, DT; Verma, C; Zhou, L; Zou, H1
Antunes, NT; Boudreau, MA; Chang, M; Ding, D; Lastochkin, E; Leemans, E; Lichtenwalter, K; Mobashery, S; O'Daniel, PI; Peng, Z; Pi, H; Schroeder, VA; Song, W; Spink, E; Suckow, MA; Testero, SA; Vakulenko, S; Wolter, WR1
Citron, D; He, Y; Herradura, P; Howland, K; Keith, D; Li, J; Mascio, CT; Mesleh, MF; Metcalf, C; Mortin, LI; Pearson, A; Silverman, J; Steenbergen, J; Thorne, GM; Van Praagh, AD; Yin, N1
Athanassopoulos, CM; Dinos, GP; Garnelis, T; Kalpaxis, DL; Kostopoulou, ON; Kournoutou, GG; Leotsinidis, M; Magoulas, GE; Papaioannou, D1
Bermudez, C; Butler, MS; Cooper, MA; Edwards, DJ; Elliott, AG; Fraser, JA; Huang, JX; Rees, KA; Ripen, JE; Seta, C; Yeo, TC1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Steenbergen, J; Tanaka, SK; Villano, S1
Dong, Y; Golla, RM; Lushnikova, T; Wang, G; Wang, X1
Choi, H; Giri, AG; Hahn, D; Kang, H; Kim, H; Lee, J; Nam, SJ; Patil, RS; Sung, Y; Wang, W; Won, DH1
Abouelhassan, Y; Garrison, AT; Huigens, RW; Jin, S; Kallifidas, D; Kim, YS; Luesch, H; Tan, H1
Anne Marie, V; Cai, J; Li, C; Li, Y; Nimmagadda, A; Peng, Z; Su, M; Sun, X; Teng, P1
Abouelhassan, Y; Basak, A; Huigens, RW; Jin, S; Kim, YS; Norwood, VM1
Abouelhassan, Y; Garrison, AT; Huigens Iii, RW; Nguyen, TJ; Yang, H; Yousaf, HH1
Abdeen, S; Ambrose, AJ; Chapman, E; Hoang, QQ; Johnson, SM; Kunkle, T; Park, Y; Ray, AM; Salim, N; Stevens, M; Victorino, J1

Reviews

2 review(s) available for vancomycin and ly-146032

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic.
    Bioorganic & medicinal chemistry, 2016, 12-15, Volume: 24, Issue:24

    Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Drug Discovery; Humans; Microbial Sensitivity Tests; Molecular Conformation; Tetracyclines

2016

Trials

1 trial(s) available for vancomycin and ly-146032

ArticleYear
Intrapulmonary distribution of intravenous telavancin in healthy subjects and effect of pulmonary surfactant on in vitro activities of telavancin and other antibiotics.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Bronchoscopy; Female; Humans; Injections, Intravenous; Lipoglycopeptides; Lung; Macrophages, Alveolar; Male; Methicillin Resistance; Microbial Sensitivity Tests; Pulmonary Surfactants; Staphylococcus aureus; Streptococcus pneumoniae; Treatment Outcome

2008

Other Studies

78 other study(ies) available for vancomycin and ly-146032

ArticleYear
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.
    Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Dogs; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Mutation; Prodrugs; Quinolizines; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vancomycin Resistance

2005
In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:3

    Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Biofilms; DNA, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Penicillin-Binding Proteins; Penicillins; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcal Infections; Staphylococcus; Tetracycline

2007
Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Microbial Sensitivity Tests; Staphylococcus aureus; Steroids; Vancomycin Resistance

2007
Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Culture Media; Daptomycin; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Microbial Sensitivity Tests

2007
Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Daptomycin; Drug Combinations; Gentamicins; Humans; Microbial Sensitivity Tests; Monocytes; Oxacillin; Rifampin; Staphylococcus aureus; Vancomycin

2007
Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5

    Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Daptomycin; Female; Linezolid; Luminescent Measurements; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Neutropenia; Oxazolidinones; Peritonitis; Staphylococcus aureus

2007
Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5

    Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Biofilms; Catheterization, Central Venous; Daptomycin; Humans; Linezolid; Methicillin Resistance; Minocycline; Oxazolidinones; Staphylococcus aureus; Tigecycline

2007
Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Bacteriolysis; Ceftriaxone; Cell Wall; Cerebrospinal Fluid; Choline; Daptomycin; Disease Models, Animal; Humans; Meningitis, Pneumococcal; Microbial Sensitivity Tests; Penicillin Resistance; Rabbits; Streptococcus pneumoniae; Treatment Outcome; Tritium

2007
Daptomycin nonsusceptibility in Staphylococcus aureus with reduced vancomycin susceptibility is independent of alterations in MprF.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Amino Acid Substitution; Aminoacyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; Humans; Microbial Sensitivity Tests; Mutation; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2007
Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Gene Expression Regulation, Bacterial; Humans; Microbial Sensitivity Tests; Polymyxin B; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2007
In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes; Vancomycin Resistance; Viridans Streptococci

2007
Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Pyridines; Staphylococcus aureus; Thienopyridines; Thiophenes; Virginiamycin

2007
Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Anti-Bacterial Agents; Cell Division; Ciprofloxacin; Daptomycin; Erythromycin; Gentamicins; Hydrazones; Microbial Sensitivity Tests; Nafcillin; Staphylococcus aureus; Vancomycin

2007
Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Anti-Bacterial Agents; Cell Membrane; Cell Membrane Permeability; Daptomycin; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Phospholipids; Staphylococcal Infections; Staphylococcus aureus; Treatment Failure

2008
Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Gene Expression Regulation, Bacterial; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Sequence Analysis, DNA; Signal Transduction; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2008
daptomycin activity against Staphylococcus aureus following vancomycin exposure in an in vitro pharmacodynamic model with simulated endocardial vegetations.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Anti-Bacterial Agents; Culture Media; Daptomycin; Drug Therapy, Combination; Endocarditis, Bacterial; Humans; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Models, Biological; Staphylococcus aureus; Vancomycin

2008
Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Conjugation, Genetic; DNA Transposable Elements; DNA, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Humans; Michigan; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Restriction Mapping; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance

2008
Mechanisms of resistance to daptomycin in Enterococcus faecium.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Leukocyte-Adhesion Deficiency Syndrome; Microbial Sensitivity Tests; Point Mutation; Polymerase Chain Reaction; Vancomycin

2008
Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Anti-Bacterial Agents; beta-Lactams; Carbapenems; Ceftaroline; Cephalosporins; Community-Acquired Infections; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcal Infections; Staphylococcus aureus; United States

2008
Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamases; Canada; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Population Surveillance

2008
Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Anti-Bacterial Agents; Cells, Cultured; Daptomycin; Gentamicins; Humans; Macrophages; Microbial Sensitivity Tests; Monocytes; Rifampin; Staphylococcus aureus

2008
Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Genotype; Humans; Microbial Sensitivity Tests; Pneumococcal Infections; Serotyping; Streptococcus pneumoniae; Taiwan

2008
Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Daptomycin; Disease Models, Animal; Endocarditis, Bacterial; Glycopeptides; Heart Valve Diseases; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Models, Biological; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Lipoglycopeptides; Microbial Sensitivity Tests; Prospective Studies; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae; United States

2008
In vitro activity of telavancin against resistant gram-positive bacteria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus; Streptococcus

2008
Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Community-Acquired Infections; Cross Infection; Daptomycin; Drug Synergism; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin

2008
In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; United States

2008
Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1

    Topics: Anti-Infective Agents; Biofilms; Bioreactors; Electricity; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus; Staphylococcus epidermidis

2009
Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; Drug Resistance, Bacterial; Humans; Membrane Fluidity; Membrane Potentials; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oligonucleotide Array Sequence Analysis; Phenotype; Vancomycin

2008
Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Anti-Bacterial Agents; Biofilms; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Glycopeptides; Kinetics; Lipoglycopeptides; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Plankton; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2009
Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chromosome Walking; DNA-Binding Proteins; Genetic Engineering; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Point Mutation; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2009
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4

    Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dose-Response Relationship, Drug; Fusidic Acid; Gentamicins; Humans; Macrophages; Microbial Sensitivity Tests; Oxacillin; Phenotype; Protein Binding; Staphylococcus aureus; Thymidine

2009
Inhibitory and bactericidal activities of daptomycin, vancomycin, and teicoplanin against methicillin-resistant Staphylococcus aureus isolates collected from 1985 to 2007.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Abscess; Anti-Bacterial Agents; Blood; Culture Media; Daptomycin; Drug Resistance, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Staphylococcal Infections; Teicoplanin; Vancomycin

2009
Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Catheterization; Daptomycin; Microbial Sensitivity Tests; Mutation; Staphylococcus aureus; Vancomycin

2009
Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Anti-Bacterial Agents; Cell Membrane; Daptomycin; Membrane Fluidity; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phenotype; Phospholipids

2009
Impact of human serum albumin on oritavancin in vitro activity against enterococci.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Enterococcus; Glycopeptides; Lipoglycopeptides; Microbial Sensitivity Tests; Protein Binding; Serum Albumin

2009
Nine-hospital study comparing broth microdilution and Etest method results for vancomycin and daptomycin against methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Anti-Bacterial Agents; Daptomycin; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Vancomycin

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Anti-Bacterial Agents; beta-Lactams; Blotting, Northern; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Imipenem; Microbial Sensitivity Tests; Mutation; Sequence Analysis, DNA; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2009
Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Aminoglycosides; Anti-Bacterial Agents; Cell Wall; Flow Cytometry; Lipoglycopeptides; Membrane Potentials; Methicillin Resistance; Microbial Sensitivity Tests; Microscopy, Phase-Contrast; Staphylococcus aureus; Uridine Diphosphate N-Acetylmuramic Acid; Vancomycin

2009
Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-Bacterial Agents; China; Cities; Drug Resistance, Multiple, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; Vancomycin; Vancomycin Resistance

2009
In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria, Anaerobic; Clostridioides difficile; Gram-Negative Bacteria; Gram-Positive Bacteria; Lipoglycopeptides; Microbial Sensitivity Tests

2009
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Bacillus anthracis; Cell Death; Cell Line; Gram-Negative Bacteria; Gram-Positive Bacteria; Macrophages; Mice; Staphylococcus aureus; Yersinia pestis

2009
Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Daptomycin; Foreign-Body Reaction; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Rats; Rats, Wistar

2009
Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Gram-Positive Bacteria; Humans; Lipoglycopeptides; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus

2009
In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: Folic Acid Antagonists; Gram-Positive Bacteria; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phthalazines; Staphylococcus aureus; Streptococcus

2009
Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12

    Topics: Acetamides; Anti-Bacterial Agents; Cohort Studies; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Vancomycin

2009
Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Acetamides; Animals; Anti-Bacterial Agents; Cephalosporins; Chromatography, High Pressure Liquid; Daptomycin; Disease Models, Animal; Endocarditis, Bacterial; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rabbits; Random Allocation; Vancomycin

2010
Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Cattle; Daptomycin; Female; Genes, Bacterial; Gram-Positive Bacteria; Lipoproteins; Mice; Microbial Sensitivity Tests; Molecular Structure; Pneumonia, Pneumococcal; Protein Engineering; Pulmonary Surfactants; Staphylococcus aureus; Streptomyces

2010
Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; In Vitro Techniques; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Sepsis; Spain; Staphylococcal Infections; Tetrazoles; Vancomycin

2010
In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Linezolid; Lipoglycopeptides; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Virginiamycin

2010
In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Ceftaroline; Cephalosporins; Daptomycin; Drug Resistance, Multiple, Bacterial; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2010
Daptomycin is effective for treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus epidermidis.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Animals; Daptomycin; Endocarditis; Glycopeptides; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Rabbits; Staphylococcal Infections; Staphylococcus epidermidis; Vancomycin

2010
Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8

    Topics: Aminoacyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Blood; Cell Wall; Daptomycin; Drug Resistance, Multiple, Bacterial; Endocarditis, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Mutation; Octoxynol; Phenotype; Staphylococcal Infections

2010
Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxacillin; Oxazolidinones; Teicoplanin; Vancomycin Resistance

2010
In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Daptomycin; Glycopeptides; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus aureus; Vancomycin; Vancomycin Resistance; Virginiamycin

2010
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Indoles; Microbial Sensitivity Tests

2010
Increased temperature enhances the antimicrobial effects of daptomycin, vancomycin, tigecycline, fosfomycin, and cefamandole on staphylococcal biofilms.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Anti-Bacterial Agents; Biofilms; Cefamandole; Daptomycin; Fosfomycin; Minocycline; Staphylococcus; Tigecycline; Vancomycin

2010
Activities of high-dose daptomycin, vancomycin, and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Anti-Bacterial Agents; Aza Compounds; Biofilms; Clarithromycin; Daptomycin; Fluoroquinolones; Microscopy, Electron, Scanning; Moxifloxacin; Quinolines; Rifampin; Staphylococcus aureus; Vancomycin

2010
An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; Drug Resistance, Multiple, Bacterial; Mutation; Polymorphism, Single Nucleotide; Staphylococcus aureus; Vancomycin

2010
Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pneumonia; Staphylococcal Infections; Vancomycin

2010
Flow cytometry as a tool to determine the effects of cell wall-active antibiotics on vancomycin-susceptible and -resistant Enterococcus faecalis strains.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1

    Topics: Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Enterococcus faecalis; Flow Cytometry; Lipoglycopeptides; Microscopy, Confocal; Vancomycin

2011
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Animals; Anti-Bacterial Agents; DNA Polymerase III; Enzyme Inhibitors; Escherichia coli; Gram-Positive Bacteria; Guanine; Mice; Microbial Sensitivity Tests; Staphylococcal Infections

2011
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
    Journal of natural products, 2012, Dec-28, Volume: 75, Issue:12

    Topics: 4-Butyrolactone; Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Bacteria; Linezolid; Marine Biology; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazolidinones; Republic of Korea; Urochordata; Vancomycin

2012
Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Bacteria; Cell Membrane; Chemistry Techniques, Synthetic; Drug Design; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Molecular Conformation; Molecular Dynamics Simulation; Rabbits; Substrate Specificity; Xanthones

2013
Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections.
    Journal of medicinal chemistry, 2015, Jan-22, Volume: 58, Issue:2

    Topics: Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacterial Infections; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Rabbits; Structure-Activity Relationship; Unilamellar Liposomes; Xanthones

2015
Structure-activity relationship for the oxadiazole class of antibiotics.
    Journal of medicinal chemistry, 2015, Feb-12, Volume: 58, Issue:3

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Staphylococcus aureus; Structure-Activity Relationship

2015
Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea.
    Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Clostridioides difficile; Cricetinae; Diarrhea; Enterocolitis, Pseudomembranous; Lipopeptides; Male; Microbial Sensitivity Tests; Peptides, Cyclic; Structure-Activity Relationship

2015
Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Acetyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Chloramphenicol; Enzyme Assays; Escherichia coli; Gene Expression; Kinetics; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation; Phthalic Anhydrides; Spermidine; Succinic Anhydrides

2015
Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.
    Journal of natural products, 2015, Aug-28, Volume: 78, Issue:8

    Topics: Chalcones; Fabaceae; Gram-Positive Bacteria; HEK293 Cells; Humans; Malaysia; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Prenylation; Rainforest

2015
Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Drug Design; Molecular Structure; Peptides; Small Molecule Libraries; Structure-Activity Relationship

2017
Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja.
    Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3

    Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Gram-Positive Bacteria; Microbial Sensitivity Tests; Molecular Structure; Republic of Korea; Structure-Activity Relationship; Urochordata

2017
An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.
    Journal of medicinal chemistry, 2018, 05-10, Volume: 61, Issue:9

    Topics: Anti-Bacterial Agents; Biofilms; Cyclization; Halogenation; HeLa Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phenazines

2018
Facilely accessible quinoline derivatives as potent antibacterial agents.
    Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Clostridioides difficile; Clostridium Infections; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Humans; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Quinolines; Structure-Activity Relationship

2018
Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis.
    European journal of medicinal chemistry, 2018, Jul-15, Volume: 155

    Topics: Anti-Bacterial Agents; Cell Survival; Dose-Response Relationship, Drug; Erythrocytes; Halogenation; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Quinolines; Staphylococcus epidermidis; Structure-Activity Relationship

2018
Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria.
    MedChemComm, 2017, Apr-01, Volume: 8, Issue:4

    Topics:

2017
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
    Journal of medicinal chemistry, 2018, 12-13, Volume: 61, Issue:23

    Topics: Amides; Anti-Bacterial Agents; Biofilms; Chaperonin 10; Chaperonin 60; HEK293 Cells; Humans; Staphylococcus aureus

2018