Page last updated: 2024-08-24

valsartan and losartan

valsartan has been researched along with losartan in 219 studies

Research

Studies (219)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (8.68)18.2507
2000's117 (53.42)29.6817
2010's62 (28.31)24.3611
2020's21 (9.59)2.80

Authors

AuthorsStudies
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR1
Anzini, M; Cappelli, A; De Benedetti, PG; Ferrari, F; Gallelli, A; Giorgi, G; Makovec, F; Mennuni, L; Menziani, MC; Pericot Mohr Gl, Gl; Rizzo, M; Vomero, S1
Berellini, G; Cruciani, G; Mannhold, R1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Anzini, M; Cappelli, A; Caselli, G; Ferrari, F; Gallelli, A; Giordani, A; Giorgi, G; Giuliani, G; Makovec, F; Mennuni, L; Mohr, Gl; Nannicini, C; Peris, W; Valenti, S; Vomero, S1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR1
Fukami, T; Hosomi, H; Iwamura, A; Nakajima, M; Yokoi, T1
Chen, ZL; Da, YJ; Jia, L; Liang, LS; Nie, YY; Tian, J; Wen, CH; Yang, XX; Zheng, H1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Abad-Santos, F; Cabaleiro, T; López-Rodríguez, R; Novalbos, J; Ochoa, D; Prieto-Pérez, R; Román, M; Talegón, M; Wojnicz, A1
Chen, ZL; Da, YJ; Liang, LS; Nie, YY; Xin, T; Yan, YJ; Ye, Y; Yuan, WD1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Foster, H; Foster, R; Philippou, H; Wilson, C1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Bauer, JH; Reams, GP1
Bühlmayer, P; Criscione, L; de Gasparo, M; Ramjoué, HP; Whitebread, S; Wood, J1
de Gasparo, M; Whitebread, S1
Biollaz, J; Brunner, HR; Buclin, T; Csajka, C1
Burrell, LM; Johnston, CI1
Brooks, DP; Feuerstein, GZ; Ohlstein, EH; Ruffolo, RR1
Bakris, GL1
Leary, A; Lim, P; MacDonald, T; Naas, A; Shiels, P1
Angiolini, M; Belvisi, L; Poma, D; Salimbeni, A; Sciammetta, N; Scolastico, C1
Brunner, HR; Burnier, M; Maillard, M; Mazzolai, L; Nussberger, J; Rossat, J1
Gatlin, M; Hedner, T; Kobi, P; Oddou-Stock, P; Oparil, S; Rapelli, A; Rasmussen, K; Sullivan, J1
Kirk, JK1
McInnes, GT1
Kaplan, NM1
Belz, GG; Butzer, R; Kober, S; Mang, C; Mutschler, E1
Spence, JD1
van Veldhuisen, DJ; Voors, AA1
Coca, A; Giner, V1
Brunner, HR; Burnier, M; Centeno, C; Daven, V; Maillard, MP; Mazzolai, L; Nussberger, J1
Petkun, W1
Benedict, C; Bunt, AM; Conlin, PR; Ribeiro, AB; Saito, I; Spence, JD; Williams, B1
Casado, S; Farré, J; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Sánchez de Miguel, L; Zalba, LR1
DelGrande, D; Shetty, SS1
Kiukaanniemi, K; Pelkonen, O; Taavitsainen, P1
Birkenhäger, WH; de Leeuw, PW1
Carey, RM; Siragy, HM1
Elliott, WJ1
Burnier, M1
Buczko, W; Chabielska, E; Chłopicki, S; Gryglewski, RJ; Koda, M1
Vidt, DG1
Arriero, MM; Cabestrero, F; Casado, S; de Miguel, LS; Farré, J; García, R; García-Colis, E; Gómez, J; Jiménez, AM; López-Farré, A; Montón, M; Núñez, A; Rico, L1
Ramahi, TM1
Casado, S; Gómez, J; Jiménez, A; Lopez-Bloya, A; López-Farré, A; Montón, M; Núñez, A; Rico, L; Sánchez de Miguel, L1
Miller, AB; Srivastava, P1
Magometschnigg, D1
Fruhwald, FM; Kickenweiz, E; Klein, W; Zweiker, R1
Coats, AJ1
Benachi, A; Daikha-Dahmane, F; Gubler, MC; Laurent, N; Martinovic, J1
Calhoun, DA; DeLucca, PT; Elliott, WJ; Gazdick, LP; Kerns, DE; Zeldin, RK1
Auer, JW; Berent, R; Eber, B1
Ogihara, T; Rakugi, H1
Komajda, M2
Carey, RM; Howell, NL; Jin, XH; Siragy, HM1
Brunner, HR; Burnier, M; Centeno, C; Maillard, MP; Nussberger, J; Würzner, G1
Akesolo, U; Alonso, RM; González, L; Jiménez, RM1
McMurray, JJ1
Casado, S; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Uriarte, AC; Velasco, S; Zalba, LR1
Belz, GG; Breithaupt-Grögler, K; Butzer, R; Fuchs, W; Hausdorf, C; Mang, C1
Carey, RM; De Gasparo, M; El-Kersh, MA; Siragy, HM; Webb, RL1
Rapi, J1
Fakouhi, K; He, W; Krause, S; Krum, H; Nolly, H; Roniker, B; Workman, D1
Andersson, OK; Elmfeldt, D; Friberg, PR; Fridman, KU; Wysocki, M1
Buczko, W; Chabielska, E; Kalinowski, L; Malinski, T; Matys, T1
Kim, S1
Sato, H1
Allcock, NM; Graham, MR1
Edvinsson, L; Malmsjö, M; Pantev, E; Stenman, E; Wackenfors, A1
Elmfeldt, D; Meredith, P; Olofsson, B1
Boonstra, PW; Buikema, H; Lübeck, RH; van Buiten, A; van Gilst, WH; van Veldhuisen, DJ; Voors, AA; Wagenaar, LJ1
Kubota, T; Takeshita, A1
Alföldi, S1
Terra, SG1
Bessard, G; Caron, F; Cracowski, JL; Hakim, A; Hoffmann, P; Sessa, C; Stanke-Labesque, F1
Preobrazhenskiĭ, DV; Sidorenko, BA; Stetsenko, TM; Tarykina, EV; Tsurko, VV1
Hashimoto, R; Kawahara, S; Matsuzaki, M; Umemoto, S1
Jermendy, G; Matos, L; Winkler, G2
Dominiak, P; Häuser, W1
Vachiéry, JL1
Buczko, W; Chabielska, E; Domaniewski, T; Kucharewicz, I; Matys, T; Pawlak, R1
Latini, R; Maggioni, AP; Masson, S; Staszewsky, L1
Pfeffer, M1
Avery, MA; Benson, SC; Chittiboyina, A; Desai, P; Ho, CI; Kurtz, TW; Pershadsingh, HA; Pravenec, M; Qi, N; Wang, J1
Ivanova, NA; Preobrazhenskiĭ, DV; Sidorenko, BA; Soplevenko, AV; Stetsenko, TM1
Anzai, T; Hashimoto, K; Himeno, H; Imai, K; Kawana, M; Kitakaze, M; Koretsune, Y; Maruyama, S; Masaoka, Y; Matsubara, H; Matsuoka, T; Miyao, Y; Miyatake, K; Miyauchi, T; Nakamura, Y; Nomura, F; Okamoto, H; Ozono, K; Sekiya, M; Shinohara, H; Shintani, U; Shiraki, T; Takaoka, H; Tsutamoto, T; Yasumura, Y; Yokoya, K; Yokoyama, H1
Bork, K; Dewald, G1
Lindholm, LH1
Suzuki, H1
Awad, AS; Carey, RM; Siragy, HM; Webb, RL1
Stumpe, KO1
Chihara, Y; Fujimori, T; Iidaka, K; Inada, H; Ishimitsu, T; Matsuoka, H; Ogihara, T; Ono, H; Ono, Y; Rakugi, H; Ueda, Y1
Chen, K; Joseph, J; Joseph, L; Li, D; Mehta, JL1
Dubiel, R; Jones, M; Smith, DH1
Komuro, I; Kuwabara, Y1
Adani, GL; Baccarani, U; Boscutti, G; Bresadola, F; Gropuzzo, M; Mioni, G; Mioni, R; Montanaro, D; Risaliti, A; Sainz, M; Tulissi, P; Vallone, C1
Erhardt, LR1
Asayama, K; Hashimoto, J; Imai, Y; Kikuya, M; Metoki, H; Nishimura, T; Ohkubo, T; Totsune, K1
Chappell, MC; Ferrario, CM; Gallagher, PE; Tallant, EA1
Barrios Alonso, V; Calderón Montero, A; Escobar Cervantes, C1
Horio, T; Inenaga, T; Kamide, K; Kawano, Y; Kubota, Y; Ogata, C; Sasaki, O; Sato, H; Suzuki, Y; Takiuchi, S1
Coleman, CI; Kalus, JS; White, CM1
Chrysant, GS; Chrysant, SG1
Cheung, BM1
Cesolari, JA; Laudanno, OM1
Chiang, CE; Coloma, R; Feig, P; Guptha, S; Ke, Y; Kim, D; Massaad, R; Sun, N; Tseng, CD; Vala, M; Watanabe, LA; Wei, M1
Iwanaga, T; Maeda, T; Ogihara, T; Sato, M; Tamai, I1
Koyabu, N; Kuwano, M; Murakami, H; Nakamura, T; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Uchiumi, T; Ushigome, F; Yamashita, F1
Imaizumi, S; Iwata, A; Kiya, Y; Kumagai, K; Matsuo, K; Miura, S; Nishikawa, H; Saku, K; Shimomura, H; Shirai, K; Zhang, B1
Bianchetti, MG; Fossali, E; Ghiglia, S; Limoni, C; Meier, CM; Salice, P; Simonetti, GD1
Giles, TD; Oparil, S; Silfani, TN; Walker, JF; Wang, A1
Behlouli, H; Hudson, M; Humphries, K; Pilote, L; Sheppard, R; Tu, JV1
Mitsuyama, S1
Akazawa, H; Komuro, I; Kudo, Y1
Cierco, M; Garrido, MR; Gutiérrez, A; Israel, A; Zavala, LE1
Murakami, M; Nakagiri, A; Sunamoto, M1
Fujino, M; Imaizumi, S; Kanazawa, T; Karnik, SS; Kiya, Y; Matsuo, Y; Miura, S; Saku, K1
Victor, RG1
Deswal, A; Mann, DL; Ramasubbu, K1
Belsey, JD1
Ikee, R; Kobayashi, S; Maesato, K; Mano, T; Moriya, H; Ohtake, T; Oka, M1
Mourad, JJ; Waeber, B1
Dal Pan, GJ; Governale, LA; Hammad, TA; McAdams, MA; Swartz, L1
Araki, R; Ikeda, N; Inoue, T; Kanno, Y; Shoda, J; Sugahara, S; Suzuki, H; Takenaka, T1
Hamamoto, Y; Honjo, S; Ikeda, H; Koshiyama, H; Nabe, K; Wada, Y1
Hatzitolios, A; Ntaios, G; Savopoulos, C1
Araki, SI; Haneda, M; Isshiki, K; Kanasaki, M; Kashiwagi, A; Koya, D; Kume, S; Sakaguchi, M; Sugiomoto, T; Uzu, T; Yokomaku, Y1
Kuji, T; Masuda, S; Okano, Y; Tamura, K; Tochikubo, O; Umemura, S1
Falvey, H; Lowy, A; Müller, E; Nixon, RM1
Ayala, C; Clavijo, S; Contreras, Y; del Rosario Brunetto, M; Delgado, Y; Estela, JM; Gallignani, M; Martin, VC; Ovalles, F; Torres, D1
Bhuiyan, MA; Hossain, M; Ishiguro, M; Miura, S; Nagatomo, T; Nakamura, T; Ozaki, M1
Harada, N; Okajima, K; Shimozawa, N1
Andraus, MH; Azevedo, CP; Borges, BC; Borges, NC; Moreira, RF; Moreno, RA; Salvadori, MC1
Hotta, H; Ishikawa, S; Itoh, T; Kim, SJ; Kuno, A; Maeda, T; Miki, T; Miura, T; Satoh, T; Shimamoto, K; Tanno, M; Terashima, Y; Togashi, N; Yano, T1
Masuda, S; Okano, Y; Ozawa, M; Tamura, K; Tochikubo, O; Umemura, S1
McMurray, JJ; Swedberg, K1
Burnier, M; Coltamai, L; Maillard, M; Simon, A; Vogt, B1
Derosa, G; Fogari, R; Mugellini, A; Preti, P; Zoppi, A1
Bhuiyan, MA; Hossain, M; Nagatomo, T; Nakamura, T; Ozaki, M1
Dong, YF; Fukuda, M; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Liu, L; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E1
Ekman, M; Fragoulakis, V; Maniadakis, N; Papagiannopoulou, V; Yfantopoulos, J1
Suzuki, H; Takenaka, T1
Arsenault, J; Cabana, J; Escher, E; Guillemette, G; Lanthier, L; Lavigne, P; Leduc, R; Lehoux, J1
Bilo, G; Mancia, G; Parati, G; Schumacher, H1
Ge, J; Gong, H; Komuro, I; Li, L; Lin, L; Wu, J; Zhou, N; Zou, Y1
Circelli, M; Cremonesi, G; Fogari, R; Mugellini, A1
Aparasu, RR; Ashton, CM; Chen, H; Desai, RJ; Deswal, A; Johnson, ML; Mehta, HB; Morgan, RO1
Duprez, D; Ferdinand, KC; Purkayastha, D; Samuel, R; Wright, RF1
Nagahama, M; Seki, M1
Inoue, A; Kuwano, T; Mitsutake, R; Miura, S; Morii, J; Saku, K; Shiga, Y; Uehara, Y1
Biskupiak, J; Qian, C; Quah, R; Ram, CV; Ramaswamy, K; Russo, PA; Ryan, A1
Baker, TM; Brede, Y; Brown, RE; Falvey, H; Goh, J; Johnston, A1
Gandhi, HP; Giridhar, R; Naik, PP; Yadav, MR1
Duprez, D; Ferdinand, K; Purkayastha, D; Samuel, R; Wright, R1
Hasegawa, H; Kameda, Y; Kobayashi, Y; Komuro, I; Kubota, A; Takano, H1
Corbalan, JJ; Jacob, RF; Jacoby, A; Kubant, R; Louka, F; Malinski, T; Mason, RP1
Joffe, MM; Yang, W1
Aksak, S; Albayrak, A; Albayrak, F; Gundogdu, C; Halici, Z; Karakus, E; Kiki, I; Ozturk, B; Polat, B; Sipal, S1
Aoyama, T; Goto, M; Goto, N; Hiei, K; Iwasa, M; Kawai, N; Kida, K; Kobayashi, H; Kojima, S; Minagawa, T; Minatoguchi, S; Oda, M; Sugishita, F; Takai, K; Tanaka, R; Watanabe, I; Yamamoto, N; Yasue, T1
Baek, IH; Kwon, KI; Lee, BY; Lee, ES1
Allen, RR; Ghushchyan, V; Kaila, S; Nair, KV; Saseen, JJ1
Asai, S; Kanou, N; Nakayama, T; Nishida, Y; Susa, N; Takahashi, Y1
Caffrey, JL; Chang, CH; Lai, MS; Lin, JW; Wu, LC1
Miyake, S; Nagai, N; Narimatsu, T; Ozawa, Y; Tsubota, K1
Komano, H; Liu, J; Liu, S; Maeda, T; Tanabe, C; Zou, K1
Gislason, GH; Kristensen, SL; Køber, L; Lamberts, M; Selmer, C; Torp-Pedersen, C; von Kappelgaard, LM1
Flavahan, NA; Flavahan, S; Leung, SW; Vanhoutte, PM; Xu, A; Zhao, Y1
Dadfarnia, S; Haghgoo, S; Khodadoust, S; Pebdani, AA; Shabani, AMH1
Asayama, K; Haga, T; Hosaka, M; Imai, Y; Inoue, R; Kikuya, M; Mano, N; Metoki, H; Murakami, T; Obara, T; Ohkubo, T; Satoh, M1
Ah, YM; Choi, KH; Choi, YJ; Han, N; Kim, B; Kong, J; Lee, HY; Lee, JY; Oh, JM; Shin, WG; Yu, YM1
Agbaba, D; Grujić, M; Nikolic, K; Popović, G; Popović, M1
Blais, C; Guénette, L; Hamel, D; Leclerc, J; Poirier, P; Rochette, L1
Abe, J; Fukuda, A; Hasegawa, S; Hatahira, H; Ishiguro, M; Kanoh, H; Kinosada, Y; Motooka, Y; Naganuma, M; Nakamura, M; Nakao, S; Sasaoka, S; Seishima, M; Ueda, N1
Adib, N; Babarahimi, V; Haghighi, F; Talebpour, Z; Vahidi, H1
Agelis, G; Androutsou, ME; Antonopoulos, M; Apostolopoulos, V; Matsoukas, J; Michalatou, M; Mikkelsen, K; Qaradakhi, T; Vlahakos, DV; Zulli, A1
Guo, CX; Li, X; Liu, JY; Liu, SK; Liu, ZQ; Luo, M; Pei, Q; Xie, P; Yang, GP; Yin, JY; Zheng, Y; Zhou, HH1
Bruno Blanch, LE; Enrique, N; Gavernet, L; Goicoechea, S; Martin, P; Milesi, V; Palestro, PH; Sabatier, LL; Villalba, ML1
Jóźwiak, K; Kocki, T; Targowska-Duda, KM; Turski, WA; Wnorowski, A; Zakrocka, I1
Bhalla, V; Byrd, JB; Chertow, GM1
Schmidt, AH; Schmidtsdorff, S1
Hebibovic, S; Jatic, Z; Rustempasic, E; Skopljak, A; Sukalo, A; Valjevac, A1
Fan, GC; Li, H; Liang, L; Peng, T; Qu, L; Yuan, W; Zhang, L1
Hernández, F; Ibáñez, M; Isaza-Pineda, L; Moncayo-Lasso, A; Serna-Galvis, EA; Torres-Palma, RA1
Arabi, M; Bagheri, AR; Ghaedi, M; Gholami, H; Ostovan, A1
Abdelsalam, RA; Haddad, GM; Marghany, KA1
Bagheri, AR; Ghaedi, M1
Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM1
Banerji, S; Mehrpour, O; Nakhaee, S; Shirazi, FM1
Assadi, M; Ebrahimi, F; Esmaeeli, A; Seyedabadi, M; Tanha, K1
Chien, CY; Lin, YT; Su, YY; Tsai, MH; Wang, HC; Yang, MY1
Bagheri, H; Taherzadeh Ghahfarrokhi, M; Zeinali, S1
Bernatchez, P; Esfandiarei, M; Milad, N; Seidman, MA; Tehrani, AY; White, Z1
Aiglova, R; Cernicek, V; Danek, J; Gloger, V; Lazarova, M; Pavlu, L; Precek, J; Schee, A; Skala, T; Taborsky, M; Vicha, M1
Batista, JM; da Silva, WM; de Sousa, EMB; Diniz, MLV; Fernandes, C; Glória, MBA1
Bester, K; Kisielius, V; Li, R; Liang, C; Svendsen, SB1
Faustino, PJ; Mohammad, A; Selaya, SD; Shakleya, D; Zhang, J1
Dantas, ASCL; de Lima, PC; de Souza, MN; Ferreira, LODS; Lima, MED; Maranho, RLDN; Monteiro, MA; Novotny, TS; Ochs, SM; Santana, DS1
Alfarraj, S; Alharbi, SA; Almoallim, HS; Ansari, MJ; Dar, AA; Dar, SA; Hassan, GI; Jan, I; Khan, NA; Mir, KB; Raina, A; Sofi, JA; Tarique, M; Wani, TA; Wani, TU1
Bradley, MC; Eworuke, E; Ghosh, RE; Hou, L; Jensen, PB; Lee, H; Maro, JC; Paterson, MJ; Pennap, D; Platt, RW; Pottegard, A; Rai, A; Scarnecchia, D; Shinde, M; Welburn, S; Woronow, D1
Bradley, M; Eworuke, E; Hedenmalm, K; Kurz, X; Lee, H; Quinten, C1
Liang, H; Tang, T; Xie, M1
Tchernev, G1
Jeong, HE; Kim, JS; Ko, H; Lim, MJ; Shin, JY; Yoo, YG1

Reviews

54 review(s) available for valsartan and losartan

ArticleYear
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship

1996
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
    Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
    Archives of internal medicine, 1995, Jul-10, Volume: 155, Issue:13

    Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

1995
Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.
    Clinical pharmacokinetics, 1997, Volume: 32, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Humans; Imidazoles; Losartan; Renin; Tetrazoles; Valine; Valsartan

1997
Angiotensin II receptor antagonists. Potential in elderly patients with cardiovascular disease.
    Drugs & aging, 1997, Volume: 10, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Heart Failure; Humans; Hypertension; Imidazoles; Kidney Diseases; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

1997
Angiotensin II receptor blockers in hypertension and renal disease.
    Hospital practice (1995), 1998, Apr-15, Volume: 33, Issue:4

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension; Kidney Diseases; Losartan; Tetrazoles; Valine; Valsartan

1998
Angiotensin-II receptor antagonists: their place in therapy.
    American family physician, 1999, Volume: 59, Issue:11

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Drug Administration Schedule; Drug Interactions; Heart Failure; Humans; Hypertension; Irbesartan; Losartan; Renin-Angiotensin System; Telmisartan; Tetrazoles; Valine; Valsartan

1999
Clinical advantage of valsartan.
    Cardiology, 1999, Volume: 91 Suppl 1

    Topics: Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Losartan; Tetrazoles; Valine; Valsartan

1999
Angiotensin II receptor antagonists in the treatment of hypertension.
    American family physician, 1999, Sep-15, Volume: 60, Issue:4

    Topics: Algorithms; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Hypertension; Irbesartan; Losartan; Receptors, Angiotensin; Telmisartan; Tetrazoles; Valine; Valsartan

1999
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
    Revista espanola de cardiologia, 1999, Volume: 52 Suppl 3

    Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

1999
Angiotensin II antagonists for hypertension: are there differences in efficacy?
    American journal of hypertension, 2000, Volume: 13, Issue:4 Pt 1

    Topics: Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Irbesartan; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan

2000
[Use of angiotensin-II-antagonists in hypertension].
    Nederlands tijdschrift voor geneeskunde, 2000, Jul-15, Volume: 144, Issue:29

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Drug Therapy, Combination; Hypertension; Losartan; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan

2000
Prospective trials of angiotensin receptor blockers: beyond blood pressure control.
    Current hypertension reports, 2000, Volume: 2, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension; Losartan; Myocardial Infarction; Tetrazoles; Valine; Valsartan

2000
Therapeutic trials comparing angiotensin converting enzyme inhibitors and angiotensin II receptor blockers.
    Current hypertension reports, 2000, Volume: 2, Issue:4

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Valine; Valsartan

2000
Angiotensin II type 1 receptor blockers.
    Circulation, 2001, Feb-13, Volume: 103, Issue:6

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan

2001
Expanded role for ARBs in cardiovascular and renal disease? Recent observations have far-reaching implications.
    Postgraduate medicine, 2001, Volume: 109, Issue:4

    Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biological Availability; Biphenyl Compounds; Cardiovascular Diseases; Humans; Imidazoles; Irbesartan; Kidney Diseases; Losartan; Metabolic Clearance Rate; Patient Selection; Renin-Angiotensin System; Telmisartan; Tetrazoles; Thiophenes; Treatment Outcome; Valine; Valsartan

2001
Angiotensin II AT(1) receptor antagonists and platelet activation.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16 Suppl 1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Coronary Disease; Coronary Thrombosis; Humans; Losartan; P-Selectin; Platelet Activation; Platelet Aggregation; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Thromboxane; Tetrazoles; Thrombosis; Thromboxane A2; Valine; Valsartan

2001
Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure.
    Cardiology clinics, 2001, Volume: 19, Issue:2

    Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart Failure; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan

2001
[Angiotensin receptor blockers--significance for the therapy of hypertension].
    Wiener medizinische Wochenschrift (1946), 2001, Volume: 151, Issue:7-8

    Topics: Acrylates; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Austria; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Prodrugs; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Valine; Valsartan

2001
[Angiotensin I receptor blockers for heart failure].
    Wiener medizinische Wochenschrift (1946), 2001, Volume: 151, Issue:7-8

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Austria; Benzimidazoles; Biphenyl Compounds; Contraindications; Cough; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Valine; Valsartan

2001
Angiotensin receptor blockers -- finally the evidence is coming in: IDNT and RENAAL.
    International journal of cardiology, 2001, Volume: 79, Issue:2-3

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diabetes Mellitus, Type 2; Humans; Hypertension; Irbesartan; Kidney Failure, Chronic; Losartan; Tetrazoles; Valine; Valsartan

2001
[Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:10

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan

2001
Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-II and Val-HeFT?
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2001, Volume: 2, Issue:2

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

2001
[Irbesartan: a new possibility in the treatment of hypertension].
    Orvosi hetilap, 2002, May-26, Volume: 143, Issue:21

    Topics: Acrylates; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Benzimidazoles; Benzoates; Biological Availability; Biphenyl Compounds; Controlled Clinical Trials as Topic; Drug Administration Schedule; Enalapril; Half-Life; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

2002
[Tendency and prospect of the development of new ARBs].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:10

    Topics: Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Humans; Losartan; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan

2002
[Acute myocardial infarction].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:10

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Clinical Trials as Topic; Coronary Restenosis; Female; Humans; Losartan; Male; Middle Aged; Myocardial Infarction; Tetrazoles; Valine; Valsartan

2002
The relationships between dose and antihypertensive effect of four AT1-receptor blockers. Differences in potency and efficacy.
    Blood pressure, 2002, Volume: 11, Issue:5

    Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Irbesartan; Losartan; Male; Randomized Controlled Trials as Topic; Receptor, Angiotensin, Type 1; Tetrazoles; Treatment Outcome; Valine; Valsartan

2002
[Treatment of heart failure based on large-scale clinical trials: renin-angiotensin system antagonists and beta-blockers].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61, Issue:5

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Drug Therapy, Combination; Evidence-Based Medicine; Heart Failure; Humans; Losartan; Mineralocorticoid Receptor Antagonists; Tetrazoles; Valine; Valsartan; Ventricular Dysfunction, Left

2003
[Diurnal blood pressure control in the optimal treatment of hypertension].
    Orvosi hetilap, 2003, May-04, Volume: 144, Issue:18 Suppl 1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Circadian Rhythm; Humans; Hypertension; Irbesartan; Losartan; Telmisartan; Tetrazoles; Valine; Valsartan

2003
[Angiotensin I receptor antagonist losartan. Part II. Effects in arterial hypertension and diabetic nephropathy].
    Kardiologiia, 2003, Volume: 43, Issue:2

    Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diastole; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Meta-Analysis as Topic; Placebos; Prognosis; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Systole; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan

2003
[Angiotensin receptor blockers in chronic heart failure].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61, Issue:9

    Topics: Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Double-Blind Method; Heart Failure; Humans; Hypertension; Japan; Losartan; Myocardial Infarction; Neurotransmitter Agents; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Valine; Valsartan; Ventricular Dysfunction, Left; Ventricular Remodeling

2003
[Theoretical background of angiotensin II receptor blockade and its features in clinical pharmacology].
    Orvosi hetilap, 2003, Sep-07, Volume: 144, Issue:36

    Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Humans; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

2003
[Cardiologic and diabetologic aspects of therapy with angiotensin receptor blocking agents].
    Orvosi hetilap, 2003, Sep-21, Volume: 144, Issue:38

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Diabetes Complications; Heart Failure; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

2003
Valsartan for the treatment of heart failure.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:1

    Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2004
[Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension].
    Kardiologiia, 2004, Volume: 44, Issue:1

    Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Tetrazoles; Thiophenes; Valine; Valsartan

2004
Angiotensin type 1 receptor blockers in chronic kidney disease.
    Contributions to nephrology, 2004, Volume: 143

    Topics: Angiotensin II Type 1 Receptor Blockers; Chronic Disease; Clinical Trials as Topic; Diabetic Nephropathies; Humans; Kidney Diseases; Losartan; Tetrazoles; Valine; Valsartan

2004
Olmesartan compared with other angiotensin II receptor antagonists: head-to-head trials.
    Clinical therapeutics, 2004, Volume: 26 Suppl A

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Valine; Valsartan

2004
[Ace inhibitors and angiotensin II receptor antagonists for therapy of chronic heart failure].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2005, Feb-10, Volume: 94, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Enalapril; Heart Failure; Humans; Indoles; Lisinopril; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

2005
A review of the current evidence for the use of angiotensin-receptor blockers in chronic heart failure.
    International journal of clinical practice, 2005, Volume: 59, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Drug Therapy, Combination; Drug Tolerance; Heart Failure; Humans; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2005
[ARB II in chronic heart failure. Coincidences and divergences. Class effect?].
    Revista clinica espanola, 2005, Volume: 205, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Heart Failure; Humans; Losartan; Systole; Tetrazoles; Valine; Valsartan

2005
Update on the efficacy of angiotensin receptor blockers in treatment of hypertension.
    The American journal of managed care, 2005, Volume: 11, Issue:13 Suppl

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Captopril; Diabetes Complications; Drug Evaluation; Humans; Hypertension; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2005
The impact of suppressing the renin-angiotensin system on atrial fibrillation.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Combined Modality Therapy; Electric Countershock; Enalapril; Humans; Indoles; Losartan; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Secondary Prevention; Tetrazoles; Valine; Valsartan

2006
The pleiotropic effects of angiotensin receptor blockers.
    Journal of clinical hypertension (Greenwich, Conn.), 2006, Volume: 8, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Diabetes Mellitus; Heart; Humans; Kidney; Losartan; Platelet Aggregation; Stroke; Tetrazoles; Uric Acid; Valine; Valsartan

2006
Therapeutic potential of angiotensin receptor blockers in hypertension.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Coronary Disease; Female; Humans; Hypertension; Losartan; Male; Meta-Analysis as Topic; Myocardial Infarction; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Survival Analysis; Tetrazoles; Valine; Valsartan

2006
[ARB: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, May-28, Volume: 65 Suppl 5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Contraindications; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Telmisartan; Tetrazoles; Valine; Valsartan

2007
[Pharmocological therapeutics for chronic heart failure--how to use ARB (angiotensin receptor blocker].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, May-28, Volume: 65 Suppl 5

    Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Myocardial Infarction; Severity of Illness Index; Survival Rate; Tetrazoles; Valine; Valsartan

2007
Pathophysiology of target-organ disease: does angiotensin II remain the key?
    Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:11 Suppl 4

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Disease Progression; Humans; Hypertension; Losartan; Myocardial Infarction; Renin; Renin-Angiotensin System; Stroke; Tetrazoles; Treatment Outcome; Valine; Valsartan

2007
Anti-angiotensin therapy: new perspectives.
    Cardiology clinics, 2007, Volume: 25, Issue:4

    Topics: Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Fumarates; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Renin; Tetrazoles; Treatment Outcome; Valine; Valsartan

2007
Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach.
    International journal of clinical practice, 2009, Volume: 63, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Middle Aged; Prospective Studies; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2009
[Recent clinical evidences of RAS inhibitors on chronic kidney diseases].
    Nihon Jinzo Gakkai shi, 2010, Volume: 52, Issue:2

    Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Evidence-Based Medicine; Fumarates; Kidney Diseases; Losartan; Tetrazoles; Valine; Valsartan

2010
Evaluating 24-h antihypertensive efficacy by the smoothness index: a meta-analysis of an ambulatory blood pressure monitoring database.
    Journal of hypertension, 2010, Volume: 28, Issue:11

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Databases, Factual; Female; Humans; Losartan; Male; Ramipril; Randomized Controlled Trials as Topic; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2010
Combination delapril/manidipine as antihypertensive therapy in high-risk patients.
    Clinical drug investigation, 2011, Volume: 31, Issue:7

    Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Diabetes Complications; Dihydropyridines; Drug Combinations; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Indans; Irbesartan; Losartan; Nitrobenzenes; Obesity; Olmesartan Medoxomil; Piperazines; Ramipril; Tetrazoles; Valine; Valsartan

2011
Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.
    Clinical cardiology, 2023, Volume: 46, Issue:8

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Essential Hypertension; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Network Meta-Analysis; Telmisartan; Tetrazoles; Valine; Valsartan

2023

Trials

30 trial(s) available for valsartan and losartan

ArticleYear
The ELITE study. Evaluation of Losartan in the Elderly Study.
    British journal of clinical pharmacology, 1998, Volume: 45, Issue:6

    Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Captopril; Creatine; Cross-Over Studies; Electrocardiography; Heart; Humans; Losartan; Male; Tetrazoles; Valine; Valsartan

1998
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:3

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Irbesartan; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Time Factors; Valine; Valsartan

1999
A comparison of the angiotensin II antagonists valsartan and losartan in the treatment of essential hypertension.
    American journal of hypertension, 1999, Volume: 12, Issue:4 Pt 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Diastole; Dizziness; Double-Blind Method; Female; Headache; Humans; Hypertension; Losartan; Male; Middle Aged; Patient Dropouts; Systole; Tetrazoles; Treatment Outcome; Valine; Valsartan

1999
Time course and extent of angiotensin II antagonism after irbesartan, losartan, and valsartan in humans assessed by angiotensin II dose response and radioligand receptor assay.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:4

    Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Confounding Factors, Epidemiologic; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Irbesartan; Losartan; Male; Radioligand Assay; Reference Values; Tetrazoles; Time Factors; Valine; Valsartan

1999
Assessment of angiotensin II receptor blockade in humans using a standardized angiotensin II receptor-binding assay.
    American journal of hypertension, 1999, Volume: 12, Issue:12 Pt 1-2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biomarkers; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Irbesartan; Losartan; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reproducibility of Results; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents

1999
Losartan versus valsartan in the treatment of patients with mild to moderate essential hypertension: data from a multicenter, randomized, double-blind, 12-week trial.
    Clinical therapeutics, 2001, Volume: 23, Issue:8

    Topics: Adult; Antihypertensive Agents; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome; Uric Acid; Valine; Valsartan

2001
Comparative angiotensin II receptor blockade in healthy volunteers: the importance of dosing.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:1

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Irbesartan; Losartan; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

2002
The pharmacological potency of various AT(1) antagonists assessed by Schild regression technique in man.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2000, Volume: 1, Issue:4

    Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Irbesartan; Losartan; Male; Receptor, Angiotensin, Type 1; Reference Values; Tetrazoles; Valine; Valsartan

2000
Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Eplerenone; Female; Headache; Heart Rate; Humans; Hypertension; Irbesartan; Losartan; Male; Middle Aged; Patient Dropouts; Renin-Angiotensin System; Spironolactone; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2002
Influence of AT1 receptor blockade on blood pressure, renal haemodynamics and hormonal responses to intravenous angiotensin II infusion in hypertensive patients.
    Blood pressure, 2002, Volume: 11, Issue:4

    Topics: Adult; Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Renal Circulation; Renin; Tetrazoles; Valine; Valsartan

2002
Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure.
    Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Drug Synergism; Drug Therapy, Combination; Exercise Tolerance; Female; Heart Failure; Heart Function Tests; Humans; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Receptors, Angiotensin; Renin; Tetrazoles; Valine; Valsartan

2004
Use of 24-hour ambulatory blood pressure monitoring to assess antihypertensive efficacy: a comparison of olmesartan medoxomil, losartan potassium, valsartan, and irbesartan.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2005, Volume: 5, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Double-Blind Method; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Monitoring, Physiologic; Olmesartan Medoxomil; Single-Blind Method; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan

2005
Renoprotective effect of early inhibition of the renin-angiotensin system in renal transplant recipients.
    Transplantation proceedings, 2005, Volume: 37, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Creatinine; Enalapril; Follow-Up Studies; Humans; Hypertension; Kidney Function Tests; Kidney Transplantation; Losartan; Proteinuria; Ramipril; Renal Artery; Renin-Angiotensin System; Tetrazoles; Time Factors; Valine; Valsartan

2005
Effect on blood pressure control of switching from valsartan monotherapy to losartan/hydrochlorothiazide in Asian patients with hypertension: results of a multicentre open-label trial.
    Current medical research and opinion, 2006, Volume: 22, Issue:10

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Asian People; Blood Pressure; Drug Combinations; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Tetrazoles; Valine; Valsartan

2006
Do valsartan and losartan have the same effects in the treatment of coronary artery disease?
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:1

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Stenosis; Dose-Response Relationship, Drug; Female; Humans; Intercellular Adhesion Molecule-1; L-Selectin; Losartan; Male; Middle Aged; Myocardial Infarction; Tetrazoles; Valine; Valsartan

2007
Palatability of angiotensin II antagonists among nephropathic children.
    British journal of clinical pharmacology, 2007, Volume: 63, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Child; Child, Preschool; Female; Humans; Irbesartan; Kidney Diseases; Losartan; Male; Patient Compliance; Patient Satisfaction; Smell; Taste; Telmisartan; Tetrazoles; Valine; Valsartan

2007
Comparison of increasing doses of olmesartan medoxomil, losartan potassium, and valsartan in patients with essential hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Olmesartan Medoxomil; Severity of Illness Index; Single-Blind Method; Tetrazoles; Treatment Outcome; Valine; Valsartan

2007
[Role of the renin-angiotensin system on the sympathetic response induced by the cold pressor test in humans].
    Investigacion clinica, 2007, Volume: 48, Issue:2

    Topics: Acrylates; Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cold Temperature; Double-Blind Method; Female; Humans; Imidazoles; Losartan; Male; Receptors, Angiotensin; Renin-Angiotensin System; Sympathetic Nervous System; Tetrazoles; Thiophenes; Valine; Valsartan

2007
Effect of angiotensin receptor blockers on cardiovascular events in patients undergoing hemodialysis: an open-label randomized controlled trial.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 52, Issue:3

    Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Female; Humans; Incidence; Kidney Failure, Chronic; Losartan; Male; Middle Aged; Renal Dialysis; Tetrazoles; Valine; Valsartan

2008
Olmesartan reduced microalbuminuria in Japanese subjects with type 2 diabetes.
    Diabetes research and clinical practice, 2009, Volume: 83, Issue:1

    Topics: Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Asian People; Benzimidazoles; Benzoates; Biphenyl Compounds; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Telmisartan; Tetrazoles; Valine; Valsartan

2009
Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker.
    Clinical and experimental nephrology, 2009, Volume: 13, Issue:4

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Sodium; Sodium, Dietary; Tetrazoles; Treatment Outcome; Valine; Valsartan

2009
Effects of angiotensin II receptor blockers on relationships between 24-hour blood pressure, autonomic function, and health-related QOL.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Volume: 31, Issue:3

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Autonomic Nervous System; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Health Surveys; Heart Rate; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Quality of Life; Telmisartan; Tetrazoles; Valine; Valsartan

2009
Simultaneous determination of losartan and hydrochlorothiazide in human plasma by LC/MS/MS with electrospray ionization and its application to pharmacokinetics.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Volume: 31, Issue:5

    Topics: Administration, Oral; Adult; Chlorthalidone; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Humans; Hydrochlorothiazide; Losartan; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tetrazoles; Therapeutic Equivalency; Valine; Valsartan

2009
Effects of angiotensin II receptor blockers on the relationships between ambulatory blood pressure and anti-hypertensive effects, autonomic function, and health-related quality of life.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Volume: 31, Issue:8

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Heart Rate; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Quality of Life; Sympathetic Nervous System; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2009
Comparative vascular and renal tubular effects of angiotensin II receptor blockers combined with a thiazide diuretic in humans.
    Journal of hypertension, 2010, Volume: 28, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Imidazoles; Irbesartan; Kidney Tubules; Losartan; Single-Blind Method; Tetrazoles; Valine; Valsartan

2010
Valsartan addition to amlodipine is more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine.
    Vascular health and risk management, 2010, Mar-03, Volume: 6

    Topics: Adult; Aged; Amlodipine; Anthracenes; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Tetrazoles; Valine; Valsartan

2010
Combination angiotensin-receptor blocker (ARB)/calcium channel blocker with HCTZ vs the maximal recommended dose of an ARB with HCTZ in patients with stage 2 hypertension: the exforge as compared to losartan treatment in stage 2 systolic hypertension (EXA
    Journal of clinical hypertension (Greenwich, Conn.), 2011, Volume: 13, Issue:8

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Severity of Illness Index; Tetrazoles; Treatment Outcome; United States; Valine; Valsartan

2011
Ambulatory blood pressure response to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ.
    Vascular health and risk management, 2011, Volume: 7

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Valine; Valsartan

2011
Effect of switching from telmisartan, valsartan, olmesartan, or losartan to candesartan on morning hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2012, Volume: 34, Issue:2

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Asian People; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; Hypertension; Imidazoles; Japan; Losartan; Male; Middle Aged; Prospective Studies; Telmisartan; Tetrazoles; Valine; Valsartan

2012
Comparative effect of candesartan and amlodipine, and effect of switching from valsartan, losartan, telmisartan and olmesartan to candesartan, on early morning hypertension and heart rate.
    Blood pressure, 2013, Volume: 22 Suppl 1

    Topics: Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Drug Substitution; Female; Heart Rate; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Prospective Studies; Telmisartan; Tetrazoles; Valine; Valsartan

2013

Other Studies

135 other study(ies) available for valsartan and losartan

ArticleYear
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.
    Journal of medicinal chemistry, 2004, May-06, Volume: 47, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Imidazoles; In Vitro Techniques; Isometric Contraction; Ligands; Liver; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Purines; Pyridines; Quinolines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles

2004
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Drug Design; Humans; Intestinal Mucosa; Male; Models, Molecular; Molecular Structure; Pyrazoles; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Stereoisomerism; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:5

    Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Losartan; NF-E2-Related Factor 2; Semicarbazides; Sensitivity and Specificity; Time Factors; Uricosuric Agents

2011
Synthesis and biological evaluation of novel potent angiotensin II receptor antagonists with anti-hypertension effect.
    Bioorganic & medicinal chemistry, 2012, Apr-15, Volume: 20, Issue:8

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Dose-Response Relationship, Drug; Molecular Conformation; Molecular Structure; Rats; Rats, Inbred SHR

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Evaluation of the relationship between sex, polymorphisms in CYP2C8 and CYP2C9, and pharmacokinetics of angiotensin receptor blockers.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Alleles; Angiotensin Receptor Antagonists; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Female; Half-Life; Humans; Male; Polymorphism, Genetic; Reference Values; Sex Factors

2013
Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects.
    Bioorganic & medicinal chemistry, 2012, Dec-15, Volume: 20, Issue:24

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Antineoplastic Agents; Cell Line, Tumor; Humans; Hydrocarbons, Fluorinated; Hypertension; Male; Mice; Mice, Nude; Prostatic Neoplasms; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2012
Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis.
    Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21

    Topics: Binding Sites; Biological Products; Humans; Ligands; Losartan; Molecular Dynamics Simulation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Signal Transduction; Small Molecule Libraries; Thrombosis

2020
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cattle; Female; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Rats; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan

1993
Binding of valsartan to mammalian angiotensin AT1 receptors.
    Regulatory peptides, 1995, Nov-10, Volume: 59, Issue:3

    Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Biphenyl Compounds; Callithrix; Cell Membrane; Dogs; Humans; Imidazoles; Liver; Losartan; Molecular Structure; Muscle, Smooth, Vascular; Protein Binding; Rats; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan

1995
Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade.
    Pharmacology, 1997, Volume: 55, Issue:5

    Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Decerebrate State; Electric Stimulation; Imidazoles; Irbesartan; Losartan; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Thiophenes; Valine; Valsartan

1997
Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units.
    Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:11

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Drug Design; Humans; Imidazoles; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Molecular Structure; Static Electricity; Stereoisomerism; Structure-Activity Relationship; Tetrazoles; Valine; Valsartan

1998
Efficacy of angiotensin II antagonists in hypertension.
    The Canadian journal of cardiology, 1999, Volume: 15 Suppl F

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diuretics; Drug Interactions; Drug Therapy, Combination; Humans; Hypertension; Irbesartan; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Valine; Valsartan

1999
Blockade of the renin angiotensin system in heart failure: the potential place of angiotensin II receptor blockers.
    European heart journal, 2000, Volume: 21, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Heart Failure; Humans; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

2000
AT1-receptor blockers.
    European heart journal, 2000, Volume: 21, Issue:4

    Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Heart Failure; Humans; Hypertension; Irbesartan; Losartan; Meta-Analysis as Topic; Tetrazoles; Valine; Valsartan

2000
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan

2000
Differential inhibition of the prejunctional actions of angiotensin II in rat atria by valsartan, irbesartan, eprosartan, and losartan.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:1

    Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Heart; Imidazoles; Irbesartan; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles; Thiophenes; Valine; Valsartan

2000
In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:2

    Topics: Acrylates; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Imidazoles; In Vitro Techniques; Inhibitory Concentration 50; Irbesartan; Losartan; Microsomes, Liver; Protein Isoforms; Tetrazoles; Thiophenes; Valine; Valsartan

2000
Antiplatelet action of losartan involves TXA2 receptor antagonism but not TXA2 synthase inhibition.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2000, Volume: 51, Issue:4 Pt 1

    Topics: Antihypertensive Agents; Blood Platelets; Collagen; Humans; Imidazoles; Losartan; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Tetrazoles; Thromboxane-A Synthase; Valine; Valsartan

2000
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
    Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:3

    Topics: Acrylates; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Black or African American; Clinical Trials as Topic; Cough; Female; Humans; Imidazoles; Irbesartan; Losartan; Male; Randomized Controlled Trials as Topic; Sex Factors; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

2001
Inhibition of platelet activation in stroke-prone spontaneously hypertensive rats: comparison of losartan, candesartan, and valsartan.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Platelets; Blood Pressure; Humans; Hypertension; Losartan; P-Selectin; Platelet Activation; Platelet Adhesiveness; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Tetrazoles; Thromboxane A2; Valine; Valsartan

2001
Fetal toxic effects and angiotensin-II-receptor antagonists.
    Lancet (London, England), 2001, Jul-21, Volume: 358, Issue:9277

    Topics: Abnormalities, Drug-Induced; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Humans; Hypertension; Losartan; Pregnancy; Pregnancy Complications, Cardiovascular; Tetrazoles; Valine; Valsartan

2001
Angiotensin II type 1 receptor blockers and congestive heart failure.
    Circulation, 2001, Oct-09, Volume: 104, Issue:15

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Receptor, Angiotensin, Type 1; Sample Size; Selection Bias; Tetrazoles; Treatment Outcome; Valine; Valsartan

2001
Are angiotensin II receptor blockers indicated in chronic heart failure?
    Heart (British Cardiac Society), 2002, Volume: 87, Issue:1

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Chronic Disease; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan

2002
Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats.
    Hypertension (Dallas, Tex. : 1979), 2001, Dec-01, Volume: 38, Issue:6

    Topics: Angiotensin Receptor Antagonists; Animals; Blood Pressure Determination; Diet, Sodium-Restricted; Hypotension; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan; Vasodilation

2001
Application of capillary zone electrophoresis to the screening of some angiotensin II receptor antagonists.
    Electrophoresis, 2002, Volume: 23, Issue:2

    Topics: Acrylates; Angiotensin Receptor Antagonists; Benzimidazoles; Benzoates; Biphenyl Compounds; Chemical Fractionation; Electrophoresis, Capillary; Imidazoles; Irbesartan; Losartan; Mathematical Computing; Molecular Structure; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

2002
Losartan inhibits in vitro platelet activation: comparison with candesartan and valsartan.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2000, Volume: 1, Issue:2

    Topics: Adenosine Diphosphate; Adult; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Platelets; Cells, Cultured; Drug Interactions; Humans; Losartan; Male; Platelet Activation; Platelet Aggregation Inhibitors; Receptor, Angiotensin, Type 1; Tetrazoles; Thromboxane A2; Valine; Valsartan

2000
Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP.
    Journal of hypertension, 2002, Volume: 20, Issue:6

    Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cyclic GMP; Extracellular Space; Female; Imidazoles; Injections, Intravenous; Kidney; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan

2002
Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:4

    Topics: Angiotensin Receptor Antagonists; Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Kinetics; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan

2002
Irbesartan substitution for valsartan or losartan in treating hypertension.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:12

    Topics: Aged; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Irbesartan; Losartan; Male; Middle Aged; Retrospective Studies; Tetrazoles; Therapeutic Equivalency; Valine; Valsartan

2002
Comparison of the antagonistic effects of different angiotensin II receptor blockers in human coronary arteries.
    European journal of heart failure, 2002, Volume: 4, Issue:6

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Base Sequence; Benzimidazoles; Biphenyl Compounds; Coronary Vessels; Culture Techniques; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Losartan; Male; Middle Aged; Molecular Sequence Data; Probability; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstriction

2002
[Lowering blood pressure with sartans. Are there differences?].
    MMW Fortschritte der Medizin, 2002, Nov-21, Volume: 144, Issue:47

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Cross-Over Studies; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Telmisartan; Tetrazoles; Valine; Valsartan

2002
Are angiotensin II receptor antagonists indicated in chronic heart failure?
    Heart failure monitor, 2002, Volume: 2, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2002
Functional antagonism of different angiotensin II type I receptor blockers in human arteries.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents

2002
Cardiology patient page. Angiotensin receptor blockers.
    Circulation, 2003, Jun-24, Volume: 107, Issue:24

    Topics: Acrylates; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Diuretics; Dizziness; Drug Combinations; Drug Interactions; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Kidney Diseases; Losartan; Olmesartan Medoxomil; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

2003
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Drug Antagonism; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Tetrazoles; Valine; Valsartan

2003
[Fast-acting sartan. High blood pressure therapy without long waiting time].
    MMW Fortschritte der Medizin, 2003, Jun-12, Volume: 145, Issue:24

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Rats; Tetrazoles; Time Factors; Valine; Valsartan

2003
[Dosage equivalents of AT1-receptor antagonists available in Germany].
    Deutsche medizinische Wochenschrift (1946), 2003, Oct-31, Volume: 128, Issue:44

    Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan

2003
[ACE inhibitors and/or sartans in heart failure: is there a difference?].
    Revue medicale de Bruxelles, 2003, Volume: 24, Issue:4

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Losartan; Tetrazoles; Valine; Valsartan

2003
Nitric oxide-dependent antiplatelet action of AT1-receptor antagonists in a pulmonary thromboembolism in mice.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Imidazoles; Injections, Intraperitoneal; Losartan; Mice; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rats; Tetrazoles; Valine; Valsartan

2003
[New options against undertreatment].
    MMW Fortschritte der Medizin, 2003, Dec-04, Volume: 145, Issue:49

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Clinical Trials as Topic; Heart Failure; Hospitalization; Humans; Losartan; Myocardial Infarction; Risk Factors; Stroke Volume; Tetrazoles; Time Factors; Valine; Valsartan

2003
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5

    Topics: Adipocytes; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Glucose; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Drug Evaluation, Preclinical; Gene Expression Regulation; Imidazoles; Insulin; Irbesartan; Losartan; Male; Mice; Models, Molecular; Myoblasts; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Structure-Activity Relationship; Telmisartan; Tetrazoles; Thiazoles; Thiazolidinediones; Thiazolidines; Transcription Factors; Triglycerides; Valine; Valsartan; Weight Gain

2004
Hereditary angioedema type III, angioedema associated with angiotensin II receptor antagonists, and female sex.
    The American journal of medicine, 2004, May-01, Volume: 116, Issue:9

    Topics: Aged; Angioedema; Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Humans; Losartan; Sex Factors; Tetrazoles; Valine; Valsartan

2004
[AT-1 blockers are different in their effects. The forgetful patients begin to notice it especially].
    MMW Fortschritte der Medizin, 2003, Apr-10, Volume: 145, Issue:15

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diuretics; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Losartan; Meta-Analysis as Topic; Placebos; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Stroke; Tetrazoles; Time Factors; Valine; Valsartan

2003
Valsartan treatment of hypertension--does VALUE add value?
    Lancet (London, England), 2004, Jun-19, Volume: 363, Issue:9426

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Endpoint Determination; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Valine; Valsartan

2004
Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.
    Journal of hypertension, 2004, Volume: 22, Issue:8

    Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Fluid; Kidney; Losartan; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan

2004
[Angiotensin type 1 receptor blocker reduced proteinuria in patients of focal glomerular sclerosis].
    Nihon Jinzo Gakkai shi, 2004, Volume: 46, Issue:5

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Diet, Protein-Restricted; Drug Therapy, Combination; Glomerulosclerosis, Focal Segmental; Humans; Immunosuppressive Agents; Losartan; Male; Methylprednisolone; Middle Aged; Prednisolone; Proteinuria; Remission Induction; Ribonucleosides; Tetrazoles; Valine; Valsartan

2004
[Despite drug treatment, ever second hypertensive patient with morning blood pressure too high].
    MMW Fortschritte der Medizin, 2004, Aug-19, Volume: 146, Issue:33-34

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Circadian Rhythm; Clinical Trials as Topic; Drug Administration Schedule; Humans; Hypertension; Losartan; Telmisartan; Tetrazoles; Valine; Valsartan

2004
Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II.
    Circulation research, 2004, Dec-10, Volume: 95, Issue:12

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antibodies, Monoclonal; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Collagen Type I; Endoglin; Fibroblasts; Flavonoids; Gene Expression Regulation; Imidazoles; Intracellular Signaling Peptides and Proteins; Losartan; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Tetrazoles; Valine; Valsartan

2004
Efficacy and duration of action of the four selective angiotensin II subtype 1 receptor blockers, losartan, candesartan, valsartan and telmisartan, in patients with essential hypertension determined by home blood pressure measurements.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2005, Volume: 27, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Telmisartan; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan

2005
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes.
    American journal of physiology. Cell physiology, 2006, Volume: 290, Issue:2

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Astrocytes; Carboxypeptidases; Cells, Cultured; Cerebellum; Female; Gene Expression Regulation; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Peptidyl-Dipeptidase A; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents

2006
Evaluation of intrarenal hemodynamics by Doppler ultrasonography for renoprotective effect of angiotensin receptor blockade.
    Clinical nephrology, 2005, Volume: 64, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Female; Hemodynamics; Humans; Hypertension; Kidney; Kidney Diseases; Losartan; Male; Middle Aged; Tetrazoles; Ultrasonography, Doppler; Valine; Valsartan

2005
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
    Acta gastroenterologica Latinoamericana, 2006, Volume: 36, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl Compounds; Carrageenan; Disease Models, Animal; Edema; Female; Gastric Mucosa; Indomethacin; Losartan; Rats; Rats, Wistar; Stomach Ulcer; Tetrazoles; Valine; Valsartan

2006
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Organic Anion Transporters; Organic Cation Transport Proteins; Pyrazinamide; Tetrazoles; Uric Acid; Valine; Valsartan; Xenopus laevis

2007
Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:11

    Topics: Acetates; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biological Transport; Biphenyl Compounds; Blotting, Western; Cell Line; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Estrone; Humans; Imidazoles; Indoles; Leukotriene Antagonists; Losartan; Molecular Structure; Organic Anion Transporters, Sodium-Independent; Phenylcarbamates; Quinolines; Structure-Activity Relationship; Sulfides; Sulfonamides; Tetrazoles; Tosyl Compounds; Transfection; Tritium; Valine; Valsartan

2006
Angiotensin II receptor blockers for the treatment of heart failure: a class effect?
    Pharmacotherapy, 2007, Volume: 27, Issue:4

    Topics: Age Factors; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; British Columbia; Drug Prescriptions; Female; Heart Failure; Hospital Information Systems; Humans; Irbesartan; Losartan; Male; Ontario; Proportional Hazards Models; Quebec; Retrospective Studies; Survival Analysis; Survival Rate; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2007
Angiotensin AT1 receptor blockers suppress ischemia/reperfusion-induced gastric injury in rats.
    Inflammopharmacology, 2007, Volume: 15, Issue:4

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Capillary Permeability; Gastric Mucosa; Hydrogen Peroxide; Losartan; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetrazoles; Valine; Valsartan

2007
Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Binding Sites; Chlorocebus aethiops; Computer Simulation; COS Cells; Imidazoles; Losartan; Lysine; Molecular Structure; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptor, Angiotensin, Type 1; Serine; Structure-Activity Relationship; Tetrazoles; Valine; Valsartan

2008
Switch strategies in the management of hypertension: a cost minimisation analysis of angiotensin receptor blocker based regimen.
    Current medical research and opinion, 2008, Volume: 24, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cost-Benefit Analysis; Drug Costs; Humans; Hypertension; Irbesartan; Losartan; Markov Chains; Tetrazoles; Valine; Valsartan

2008
Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:3

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biopsy; Creatinine; Female; Fibrosis; Glomerulonephritis, Membranoproliferative; Humans; Immunoglobulin A; Kidney Glomerulus; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Retrospective Studies; Telmisartan; Tetrazoles; Valine; Valsartan; Vasodilation

2008
Application in the STRATHE trial of a score system to compare the efficacy and the tolerability of different therapeutic strategies in the management of hypertension.
    Vascular health and risk management, 2008, Volume: 4, Issue:1

    Topics: Amlodipine; Antihypertensive Agents; Atenolol; Double-Blind Method; Drug Therapy, Combination; France; Humans; Hydrochlorothiazide; Hypertension; Indapamide; Losartan; Perindopril; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Valine; Valsartan

2008
Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs: revisiting the Weber effect.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:9

    Topics: Adverse Drug Reaction Reporting Systems; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Drug Approval; Humans; Irbesartan; Losartan; Tetrazoles; Time Factors; United States; Valine; Valsartan

2008
Telmisartan and carotid intima-media thickness regression: a class effect of angiotensin-receptor blockers?
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:12

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Carotid Arteries; Humans; Irbesartan; Losartan; Telmisartan; Tetrazoles; Tunica Intima; Tunica Media; Valine; Valsartan

2008
Determination of losartan, telmisartan, and valsartan by direct injection of human urine into a column-switching liquid chromatographic system with fluorescence detection.
    Journal of pharmaceutical and biomedical analysis, 2009, Sep-08, Volume: 50, Issue:2

    Topics: Antihypertensive Agents; Benzimidazoles; Benzoates; Chromatography, High Pressure Liquid; Humans; Losartan; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Telmisartan; Tetrazoles; Valine; Valsartan

2009
Binding sites of valsartan, candesartan and losartan with angiotensin II receptor 1 subtype by molecular modeling.
    Life sciences, 2009, Jul-17, Volume: 85, Issue:3-4

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Cell Line; Humans; Losartan; Models, Molecular; Protein Conformation; Radioligand Assay; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan

2009
AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.
    Translational research : the journal of laboratory and clinical medicine, 2009, Volume: 154, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hypertension; Imidazoles; Insulin-Like Growth Factor I; Kidney; Losartan; Male; Myocardium; Nifedipine; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; RNA, Messenger; Sensory Receptor Cells; Telmisartan; Tetrazoles; Valine; Valsartan; Vasodilator Agents

2009
Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.
    Circulation research, 2010, Jan-08, Volume: 106, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Calcineurin; Diabetes Mellitus, Type 2; Enkephalin, Leucine-2-Alanine; Erythropoietin; Immunosuppressive Agents; Ischemic Preconditioning, Myocardial; Janus Kinase 2; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred OLETF; Receptor, Angiotensin, Type 1; Receptors, Opioid, delta; Signal Transduction; Species Specificity; Tacrolimus; Tetrazoles; Up-Regulation; Valine; Valsartan

2010
HEAAL: the final chapter in the story of angiotensin receptor blockers in heart failure--lessons learnt from a decade of trials.
    European journal of heart failure, 2010, Volume: 12, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Evidence-Based Medicine; Heart Failure; Humans; Losartan; Tetrazoles; Time Factors; Valine; Valsartan

2010
Internalization of constitutively active N111G MUTANT of AT1 receptor induced by angiotensin II-receptor antagonists candesartan, losartan, and telmisartan: comparison with valsartan.
    Journal of pharmacological sciences, 2010, Volume: 112, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Chlorocebus aethiops; COS Cells; Losartan; Mutagenesis, Site-Directed; Mutation; Receptor, Angiotensin, Type 1; Telmisartan; Tetrazoles; Valine; Valsartan

2010
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice.
    Journal of hypertension, 2010, Volume: 28, Issue:7

    Topics: Albuminuria; Amides; Animals; Collagen Type IV; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Synergism; Fumarates; Kidney Glomerulus; Losartan; Male; Mice; Mice, Inbred C57BL; Tetrazoles; Transforming Growth Factor beta; Valine; Valsartan

2010
Economic evaluation of irbesartan in combination with hydrochlorothiazide in the treatment of hypertension in Greece.
    The European journal of health economics : HEPAC : health economics in prevention and care, 2011, Volume: 12, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Diseases; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Combinations; Female; Greece; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Male; Markov Chains; Middle Aged; Models, Economic; Quality of Life; Sex Factors; Tetrazoles; Valine; Valsartan

2011
A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:6

    Topics: Alanine; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Chlorocebus aethiops; COS Cells; Humans; Imidazoles; Inositol Phosphates; Irbesartan; Losartan; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1; Telmisartan; Tetrazoles; Threonine; Valine; Valsartan

2010
Comparison of angiotensin II type 1-receptor blockers to regress pressure overload-induced cardiac hypertrophy in mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:12

    Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Echocardiography; Gene Expression; Hemodynamics; Imidazoles; Losartan; Male; Mice; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2010
Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:3

    Topics: Aged; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Confounding Factors, Epidemiologic; Electronic Health Records; Female; Heart Failure; Hospitalization; Humans; Irbesartan; Losartan; Male; Models, Structural; Proportional Hazards Models; Retrospective Studies; Risk; Tetrazoles; Treatment Outcome; United States; Valine; Valsartan

2012
Synthesis of angiotensin II receptor blockers by means of a catalytic system for C-H activation.
    The Journal of organic chemistry, 2011, Dec-16, Volume: 76, Issue:24

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Catalysis; Chelating Agents; Humans; Losartan; Magnetic Resonance Spectroscopy; Ruthenium; Tetrazoles; Tetrazolium Salts; Valine; Valsartan

2011
Comparison of the efficacy and safety of single-pill fixed-dose combinations of losartan/hydrochlorothiazide and valsartan/hydrochlorothiazide in patients with hypertension (SALT-VAT study).
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:21

    Topics: Aged; Blood Pressure; Drug Combinations; Drug Substitution; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome; Valine; Valsartan

2011
Blood pressure outcomes in patients receiving angiotensin II receptor blockers in primary care: a comparative effectiveness analysis from electronic medical record data.
    Journal of clinical hypertension (Greenwich, Conn.), 2011, Volume: 13, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Black or African American; Blood Pressure; Diabetes Mellitus; Electronic Health Records; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Obesity; Primary Health Care; Retrospective Studies; Tetrazoles; Treatment Outcome; Valine; Valsartan; White People; Young Adult

2011
Cost-effectiveness analysis of valsartan versus losartan and the effect of switching.
    Journal of medical economics, 2012, Volume: 15, Issue:2

    Topics: Antihypertensive Agents; Cardiovascular Diseases; Cost-Benefit Analysis; Drug Substitution; Fees, Pharmaceutical; Humans; Hypertension; Insurance, Health, Reimbursement; Losartan; Outcome Assessment, Health Care; Quality-Adjusted Life Years; Tetrazoles; United States; Valine; Valsartan

2012
Revelation on the potency of α(1) -blockers - parallel blockade of angiotensin II receptor: a new finding.
    Pharmaceutical biology, 2012, Volume: 50, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Dose-Response Relationship, Drug; Doxazosin; Imidazoles; In Vitro Techniques; Losartan; Male; Molecular Structure; Prazosin; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship; Tetrazoles; Valine; Valsartan; Vasodilation; Vasodilator Agents

2012
Effects of angiotensin receptor blockers on endothelial nitric oxide release: the role of eNOS variants.
    British journal of clinical pharmacology, 2012, Volume: 74, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Losartan; Nitric Oxide; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Telmisartan; Tetrazoles; Umbilical Veins; Valine; Valsartan; Vasodilation

2012
Subtle issues in model specification and estimation of marginal structural models.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:3

    Topics: Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Female; Heart Failure; Humans; Irbesartan; Losartan; Male; Tetrazoles; Valine; Valsartan

2012
Comparative study of three angiotensin II type 1 receptor antagonists in preventing liver fibrosis in diabetic rats: stereology, histopathology, and electron microscopy.
    Journal of molecular histology, 2012, Volume: 43, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Imidazoles; Liver Cirrhosis; Losartan; Male; Microscopy, Electron; Rats; Tetrazoles; Valine; Valsartan

2012
Pharmacokinetics of angiotensin II receptor blockers in the dog following a single oral administration.
    Drug research, 2013, Volume: 63, Issue:7

    Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Area Under Curve; Benzimidazoles; Benzoates; Chromatography, Liquid; Dogs; Dose-Response Relationship, Drug; Half-Life; Losartan; Male; Models, Biological; Tandem Mass Spectrometry; Telmisartan; Tetrazoles; Tissue Distribution; Valine; Valsartan

2013
Maintaining goal blood pressures after switching from olmesartan to other angiotensin receptor blockers.
    Journal of clinical hypertension (Greenwich, Conn.), 2013, Volume: 15, Issue:12

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Drug Substitution; Female; Follow-Up Studies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Retrospective Studies; Tetrazoles; Treatment Outcome; Valine; Valsartan

2013
Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study.
    Cardiovascular diabetology, 2013, Nov-04, Volume: 12

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Imidazoles; Logistic Models; Losartan; Male; Middle Aged; Multivariate Analysis; Olmesartan Medoxomil; Retrospective Studies; Telmisartan; Tetrazoles; Treatment Outcome; Uric Acid; Valine; Valsartan

2013
Examining the association of olmesartan and other angiotensin receptor blockers with overall and cause-specific mortality.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:5

    Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up Studies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Proportional Hazards Models; Registries; Retrospective Studies; Survival Rate; Taiwan; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2014
Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: Acetylcysteine; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Apoptosis; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Light; Losartan; Male; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-fos; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Retinal Degeneration; Retinal Photoreceptor Cell Outer Segment; Signal Transduction; Tetrazoles; Valine; Valsartan

2014
Differential effects of angiotensin II receptor blockers on Aβ generation.
    Neuroscience letters, 2014, May-01, Volume: 567

    Topics: Amyloid beta-Peptides; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Cells, Cultured; Fibroblasts; Imidazoles; Losartan; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Receptor, Angiotensin, Type 1; Signal Transduction; Telmisartan; Tetrazoles; Valine; Valsartan

2014
Dosage of angiotensin-II receptor blockers in heart failure patients following changes in Danish drug reimbursement policies.
    Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:12

    Topics: Aged; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Denmark; Female; Heart Failure; Humans; Insurance, Health, Reimbursement; Losartan; Male; Tetrazoles; Valine; Valsartan

2014
Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.
    American journal of physiology. Heart and circulatory physiology, 2015, Feb-15, Volume: 308, Issue:4

    Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Arteries; Endothelium, Vascular; Hydrazines; Hypertension; Indoles; Losartan; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Tetrazoles; Valine; Valsartan; Vasodilation

2015
Application of modified stir bar with nickel:zinc sulphide nanoparticles loaded on activated carbon as a sorbent for preconcentration of losartan and valsartan and their determination by high performance liquid chromatography.
    Journal of chromatography. A, 2016, Mar-11, Volume: 1437

    Topics: Carbon; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Limit of Detection; Losartan; Nanoparticles; Nickel; Osmolar Concentration; Sulfides; Valsartan; Zinc Compounds

2016
The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements.
    Journal of hypertension, 2016, Volume: 34, Issue:6

    Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Blood Pressure Determination; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Oxadiazoles; Self Care; Telmisartan; Tetrazoles; Time Factors; Valsartan

2016
Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population-based study.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2016, Volume: 38, Issue:3

    Topics: Acrylates; Adult; Aged; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cohort Studies; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Medication Adherence; Middle Aged; Outcome Assessment, Health Care; Republic of Korea; Retrospective Studies; Risk Factors; Tetrazoles; Thiophenes; Valsartan

2016
Protolytic Equilibria of Sartans in Micellar Solutions of Differently Charged Surfactants.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:8

    Topics: Biphenyl Compounds; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Irbesartan; Losartan; Micelles; Molecular Structure; Protons; Solubility; Solutions; Solvents; Surface-Active Agents; Tetrazoles; Valsartan; Water

2016
Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis.
    Circulation. Cardiovascular quality and outcomes, 2017, Volume: 10, Issue:10

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Databases, Factual; Drug Costs; Drug Substitution; Drugs, Generic; Emergency Service, Hospital; Humans; Hypertension; Losartan; Patient Admission; Patient Safety; Population Surveillance; Quebec; Referral and Consultation; Retrospective Studies; Risk Factors; Tetrazoles; Therapeutic Equivalency; Time Factors; Treatment Outcome; Valsartan

2017
Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database.
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:12

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Humans; Hydrochlorothiazide; Incidence; Japan; Ketoprofen; Losartan; Male; Middle Aged; Odds Ratio; Photosensitivity Disorders; Seasons; Sodium Chloride Symporter Inhibitors; Valsartan; Young Adult

2017
Validated determination of losartan and valsartan in human plasma by stir bar sorptive extraction based on acrylate monolithic polymer, liquid chromatographic analysis and experimental design methodology.
    Journal of pharmaceutical and biomedical analysis, 2018, May-10, Volume: 153

    Topics: Acrylates; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Losartan; Mass Spectrometry; Methacrylates; Plasma; Polymers; Pyrrolidinones; Reproducibility of Results; Spectrophotometry, Ultraviolet; Valsartan

2018
Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.
    Current molecular pharmacology, 2018, Volume: 11, Issue:3

    Topics: Administration, Cutaneous; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Blood Vessels; Humans; Kidney; Losartan; Male; Oligopeptides; Rabbits; Rats, Wistar; Receptor, Angiotensin, Type 1; Reproducibility of Results; Skin Absorption; Valsartan; Vasodilation

2018
Repaglinide-irbesartan drug interaction: effects of SLCO1B1 polymorphism on repaglinide pharmacokinetics and pharmacodynamics in Chinese population.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:8

    Topics: Adult; Asian People; Biphenyl Compounds; Blood Glucose; Carbamates; Cells, Cultured; China; Dose-Response Relationship, Drug; Drug Interactions; Genotype; Healthy Volunteers; Humans; Imidazoles; Irbesartan; Liver-Specific Organic Anion Transporter 1; Losartan; Male; Piperidines; Polymorphism, Single Nucleotide; Tetrazoles; Valsartan; Young Adult

2018
Searching for New Leads To Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents.
    Journal of chemical information and modeling, 2018, 07-23, Volume: 58, Issue:7

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxacin; Databases, Chemical; Epilepsy; HEK293 Cells; Humans; Losartan; Male; Mice; Molecular Conformation; Molecular Docking Simulation; NAV1.2 Voltage-Gated Sodium Channel; Protein Binding; Structure-Activity Relationship; Sulfonamides; Valsartan; Voltage-Gated Sodium Channel Blockers

2018
Angiotensin II type 1 receptor blockers decrease kynurenic acid production in rat kidney in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Kidney; Kynurenic Acid; Losartan; Male; Rats, Wistar; Telmisartan; Tetrazoles; Transaminases; Valsartan

2019
Hypertension Hot Potato - Anatomy of the Angiotensin-Receptor Blocker Recalls.
    The New England journal of medicine, 2019, Apr-25, Volume: 380, Issue:17

    Topics: Angiotensin II Type 1 Receptor Blockers; Dimethylnitrosamine; Drug Contamination; Drug Recalls; Humans; Hypertension; Irbesartan; Losartan; Nitrosamines; United States; United States Food and Drug Administration; Valsartan

2019
Simultaneous detection of nitrosamines and other sartan-related impurities in active pharmaceutical ingredients by supercritical fluid chromatography.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Angiotensin II Type 1 Receptor Blockers; Chromatography, Supercritical Fluid; Diethylnitrosamine; Dimethylnitrosamine; Drug Contamination; Limit of Detection; Losartan; Nitrosamines; Propylamines; Quality Control; Reference Standards; Risk Assessment; Valsartan

2019
Effects of Different Antihypertensive Drug Combinations on Blood Pressure and Arterial Stiffness.
    Medical archives (Sarajevo, Bosnia and Herzegovina), 2019, Volume: 73, Issue:3

    Topics: Aged; Amlodipine; Antihypertensive Agents; Arteries; Blood Pressure; Diastole; Drug Combinations; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Lisinopril; Losartan; Male; Middle Aged; Prospective Studies; Pulse Wave Analysis; Systole; Valsartan; Vascular Resistance; Vascular Stiffness

2019
Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47
    Journal of translational medicine, 2019, 08-22, Volume: 17, Issue:1

    Topics: Angiotensin II; Animals; Apelin; Apelin Receptors; ATPases Associated with Diverse Cellular Activities; Blood Pressure; Cell Size; Diastole; DNA Helicases; Enzyme Activation; Hindlimb Suspension; Losartan; Male; Mice; Muscle Proteins; Myocardium; Myocytes, Cardiac; Organ Size; Oxidative Stress; Phosphorylation; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Valsartan

2019
Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process.
    Ultrasonics sonochemistry, 2019, Volume: 58

    Topics: Antihypertensive Agents; Losartan; Models, Chemical; Oxidation-Reduction; Sonication; Valsartan; Wastewater; Water Pollutants, Chemical; Water Purification

2019
Preparation of hollow porous molecularly imprinted and aluminum(III) doped silica nanospheres for extraction of the drugs valsartan and losartan prior to their quantitation by HPLC.
    Mikrochimica acta, 2019, 10-16, Volume: 186, Issue:11

    Topics: Adult; Aluminum; Carbon; Chromatography, High Pressure Liquid; Female; Humans; Limit of Detection; Losartan; Male; Molecular Imprinting; Nanospheres; Polymerization; Polymers; Porosity; Silanes; Silicon Dioxide; Solid Phase Extraction; Valsartan

2019
HPLC method transfer study for simultaneous determination of seven angiotensin II receptor blockers.
    Journal of separation science, 2020, Volume: 43, Issue:8

    Topics: Acrylates; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Chlorthalidone; Chromatography, High Pressure Liquid; Hydrochlorothiazide; Imidazoles; Irbesartan; Losartan; Molecular Structure; Software; Tablets; Tetrazoles; Thiophenes; Valsartan

2020
Green preparation of dual-template chitosan-based magnetic water-compatible molecularly imprinted biopolymer.
    Carbohydrate polymers, 2020, May-15, Volume: 236

    Topics: Adsorption; Chitosan; Chromatography, High Pressure Liquid; Green Chemistry Technology; Limit of Detection; Losartan; Magnetite Nanoparticles; Molecular Imprinting; Reproducibility of Results; Solid Phase Extraction; Valsartan

2020
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146

    Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan

2020
Effect of angiotensin II blockers on the prognosis of COVID-19: a toxicological view.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020, Volume: 39, Issue:10

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokine Release Syndrome; Host-Pathogen Interactions; Humans; Losartan; Pandemics; Pneumonia, Viral; Prognosis; SARS-CoV-2; Severity of Illness Index; Telmisartan; Tomography, X-Ray Computed; Valsartan

2020
Low-dose angiotensin AT
    Pharmacological reports : PR, 2020, Volume: 72, Issue:6

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; beta-Arrestins; Blood Urea Nitrogen; Cisplatin; Creatinine; Ligands; Losartan; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Valsartan

2020
Angiotensin II receptor blockers valsartan and losartan improve survival rate clinically and suppress tumor growth via apoptosis related to PI3K/AKT signaling in nasopharyngeal carcinoma.
    Cancer, 2021, 05-15, Volume: 127, Issue:10

    Topics: Angiotensin Receptor Antagonists; Apoptosis; Humans; Losartan; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retrospective Studies; Signal Transduction; Survival Rate; Treatment Outcome; Valsartan

2021
Preparation of amine-modified lignin and its applicability toward online micro-solid phase extraction of valsartan and losartan in urine samples.
    Journal of chromatography. A, 2021, Apr-26, Volume: 1643

    Topics: Amines; Cellulose; Chromatography, High Pressure Liquid; Graphite; Humans; Lignin; Limit of Detection; Losartan; Reproducibility of Results; Solid Phase Microextraction; Spectrophotometry, Ultraviolet; Valsartan

2021
Blood pressure-independent inhibition of Marfan aortic root widening by the angiotensin II receptor blocker valsartan.
    Physiological reports, 2021, Volume: 9, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Losartan; Marfan Syndrome; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Culture Techniques; Valsartan

2021
Angiotensin-converting enzyme inhibitors, angiotensin-II-receptor antagonists and angiotensin-receptor blocker/neprilysin inhibitor utilization in heart failure patients: Sub-analysis of a nation-wide population-based study in the Czech Republic.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2022, Volume: 166, Issue:3

    Topics: Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Antihypertensive Agents; Czech Republic; Heart Failure; Humans; Losartan; Neprilysin; Perindopril; Ramipril; Retrospective Studies; Telmisartan; Valsartan

2022
Boron nitride nanotubes for extraction of angiotensin receptor blockers from human plasma.
    Journal of pharmaceutical and biomedical analysis, 2022, Nov-30, Volume: 221

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Boron Compounds; Chromatography, High Pressure Liquid; Humans; Losartan; Methanol; Nanotubes; Silicon Dioxide; United States; Valsartan

2022
Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism.
    Water research, 2023, Feb-01, Volume: 229

    Topics: Angiotensin II Type 1 Receptor Blockers; Biofilms; Blood Pressure; Humans; Irbesartan; Losartan; Sewage; Valsartan; Wastewater; Water Pollutants, Chemical; Water Purification

2023
Rapid Quantitation of Four Nitrosamine Impurities in Angiotensin Receptor Blocker Drug Substances.
    Journal of pharmaceutical sciences, 2023, Volume: 112, Issue:5

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Humans; Losartan; Nitrosamines; Tandem Mass Spectrometry; Valsartan

2023
Investigation of Carcinogenic Impurities of N-Nitrosamines in Sartan Pharmaceutical Products Marketed in Brazil: Development and Validation of Method Based on High-Performance Liquid Chromatography-Tandem Mass Spectrometry.
    Journal of pharmaceutical sciences, 2023, Volume: 112, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Brazil; Carcinogens; Chromatography, High Pressure Liquid; Humans; Irbesartan; Losartan; Nitrosamines; Pharmaceutical Preparations; Tandem Mass Spectrometry; Telmisartan; Valsartan

2023
Simultaneous quantification of losartan potassium and its active metabolite, EXP3174, in rabbit plasma by validated HPLC-PDA.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:8

    Topics: Animals; Chromatography, High Pressure Liquid; Losartan; Quality Control; Rabbits; Reproducibility of Results; Valsartan

2023
Valsartan, Losartan and Irbesartan use in the USA, UK, Canada and Denmark after the nitrosamine recalls: a descriptive cohort study.
    BMJ open, 2023, 04-17, Volume: 13, Issue:4

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Canada; Cohort Studies; Denmark; Humans; Hypertension; Irbesartan; Losartan; Retrospective Studies; Tetrazoles; United Kingdom; Valsartan

2023
A collaborative study of the impact of N-nitrosamines presence and ARB recall on ARB utilization - results from IQVIA™ Disease Analyzer Germany.
    European journal of clinical pharmacology, 2023, Volume: 79, Issue:6

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Germany; Humans; Hypertension; Irbesartan; Losartan; Nitrosamines; Valsartan

2023
NITROSOGENESIS OF SKIN CANCER: THE NITROSAMINE CONTAMINATION IN THE CALCIUM CHANNEL BLOCKERS (AMLODIPINE), BETA BLOCKERS (BISOPROLOL), SARTANS (VALSARTAN/LOSARTAN), ACE INHIBITORS (PERINDOPRIL/ENALAPRIL), TRICYCLIC ANTIDEPRESSANTS (MELITRACEN), SSRIS (PAR
    Georgian medical news, 2023, Issue:339

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antidepressive Agents, Tricyclic; Bisoprolol; Calcium Channel Blockers; Enalapril; Humans; Incidence; Losartan; Metformin; Paroxetine; Perindopril; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Skin Neoplasms; Valsartan; Venlafaxine Hydrochloride

2023
Risk of myocardial infarction, heart failure, and cerebrovascular disease with the use of valsartan, losartan, irbesartan, and telmisartan in patients.
    Medicine, 2023, Nov-17, Volume: 102, Issue:46

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cerebrovascular Disorders; Heart Failure; Humans; Irbesartan; Losartan; Myocardial Infarction; Retrospective Studies; Telmisartan; Tetrazoles; Valsartan

2023