Compounds > valproic acid glucuronide
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valproic acid glucuronide and valproic acid

valproic acid glucuronide has been researched along with valproic acid in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's1 (4.76)18.2507
2000's9 (42.86)29.6817
2010's7 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hall, A; Inoue, NR; Lai, WG; Williams, ET1
Dickinson, RG; Eadie, MJ; Fowler, DW1
Dickinson, RG; Dunstan, PR; Eadie, MJ; Hooper, WD1
Dickinson, RG; Eadie, MJ; Hooper, WD; Kluck, RM1
Dickinson, RG; Gerber, N; Harland, RC; Kaufman, SN; Lynn, RK1
Booth, CL; Brouwer, KL; Pollack, GM1
Azaroual, N; Cartigny, B; Imbenotte, M; Leclerc, F; Lhermitte, M; Vallée, L; Vermeersch, G1
Abbott, FS; Kumar, S; Kwan, E; Riggs, KW; Rurak, DW; Wong, H1
Andrews, J; McLaughlin, D; Reith, DM1
Shen, YZ; Yu, HY1
Bailey, MJ; Cannell, GR; Dickinson, RG1
Abbott, FS; Kumar, S; Riggs, KW; Rurak, DW; Tong, V; Wong, H1
Mizutani, T; Mori, H; Takahashi, K1
Mizutani, T; Nakahira, K; Nakamura, Y1
Baek, DJ; Chung, BC; Jung, BH; Kim, BJ; Lee, MS; Lee, YJ; Shin, KJ1
Hisaka, A; Honma, M; Ito, K; Masuo, Y; Suzuki, H; Yamamoto, T1
Cao, L; Chu, X; Guo, C; Hao, H; Wang, G; Wang, H; Xie, H; Zhang, L; Zhou, X1
Bhandary, B; Chae, HJ; Jeong, SK; Kim, HR; Marahatta, A1
Fusegawa, K; Goda, R; Ikenaga, H; Izumi, T; Kobayashi, N; Kuga, H; Nakai, D; Suzuki, E1
Huh, W; Jung, JA; Kim, JR; Ko, JW; Lee, SY; Yoo, HM1
Higuchi, N; Ishikawa, T; Kuriyama, M; Mizuta, S; Nakashima, M; Nakashima, MN; Ohyama, K; Onomura, O; Otaki, H1

Reviews

1 review(s) available for valproic acid glucuronide and valproic acid

ArticleYear
Interaction between valproic acid and carbapenem antibiotics.
    Drug metabolism reviews, 2007, Volume: 39, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Carrier Proteins; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Erythrocytes; Glucuronidase; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Kidney; Liver; Rats; Uridine Diphosphate Glucuronic Acid; Valproic Acid

2007

Trials

1 trial(s) available for valproic acid glucuronide and valproic acid

ArticleYear
Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anticonvulsants; Area Under Curve; Biotransformation; Drug Administration Schedule; Drug Interactions; Enterohepatic Circulation; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Republic of Korea; Valproic Acid; Young Adult

2015

Other Studies

19 other study(ies) available for valproic acid glucuronide and valproic acid

ArticleYear
Reversible inhibition of human carboxylesterases by acyl glucuronides.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Carboxylic Ester Hydrolases; Drug Stability; Enzyme Inhibitors; Glucuronides; Half-Life; Humans; In Vitro Techniques; Isoenzymes; Nitrophenols

2013
Transplacental transfer and biotransformation studies of valproic acid and its glucuronide(s) in the perfused human placenta.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1

    Topics: Biotransformation; Female; Humans; In Vitro Techniques; Metabolic Clearance Rate; Perfusion; Placenta; Pregnancy; Solubility; Valproic Acid

1989
Urinary excretion of valproate and some metabolites in chronically treated patients.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Hydroxylation; Male; Middle Aged; Oxidation-Reduction; Valproic Acid

1989
Disposition of beta-glucuronidase-resistant "glucuronides" of valproic acid after intrabiliary administration in the rat: intact absorption, fecal excretion and intestinal hydrolysis.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:1

    Topics: Administration, Oral; Animals; Bile; Biotransformation; Enterobacteriaceae; Feces; Glucuronidase; Hydrolysis; Intestinal Absorption; Intestinal Mucosa; Liver; Male; Rats; Valproic Acid

1985
An osmotic explanation for valproic acid induced choleresis in the rat, dog and monkey.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:3

    Topics: Animals; Anticonvulsants; Bile; Dogs; Dose-Response Relationship, Drug; Erythritol; Liver; Male; Metabolic Clearance Rate; Osmosis; Rats; Valproic Acid

1982
Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:4

    Topics: Animals; Anticonvulsants; Bile; Drug Interactions; Liver; Male; Models, Biological; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Rats, Sprague-Dawley; Valproic Acid

1996
Valproic acid intoxication identified by 1H and 1H-(13)C correlated NMR spectroscopy of urine samples.
    Magma (New York, N.Y.), 2000, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbon Isotopes; Drug Overdose; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Male; Suicide, Attempted; Valproic Acid

2000
Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:8

    Topics: Age Factors; Animals; Anticonvulsants; Blood Proteins; Fatty Acids, Monounsaturated; Female; Glucuronic Acid; Metabolic Clearance Rate; Oxidation-Reduction; Sheep; Time Factors; Valproic Acid

2000
Valproic acid has temporal variability in urinary clearance of metabolites.
    Chronobiology international, 2001, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Circadian Rhythm; Humans; Male; Valproic Acid

2001
Concentration-dependent disposition of glucuronide metabolite of valproate.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:5

    Topics: Animals; Anticonvulsants; Area Under Curve; Bile; Chromatography, Gas; Dose-Response Relationship, Drug; Guinea Pigs; Injections, Intravenous; Male; Metabolic Clearance Rate; Time Factors; Valproic Acid

2002
Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro.
    Life sciences, 2002, Oct-18, Volume: 71, Issue:22

    Topics: Animals; Cattle; GABA Agents; Isomerism; Kinetics; Microtubule Proteins; Protein Binding; Rats; Tubulin; Tubulin Modulators; Valproic Acid

2002
Kinetics of valproic acid glucuronidation: evidence for in vivo autoactivation.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8

    Topics: Animals; Catalysis; Enzyme Activation; Female; Kinetics; Microsomes, Liver; Sheep; Valproic Acid

2007
Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics.
    Drug metabolism letters, 2008, Volume: 2, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Cytosol; Drug Interactions; Enzyme Inhibitors; Glucuronidase; Humans; Hydrolysis; Liver; Microsomes, Liver; Valproic Acid

2008
The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid.
    Archives of pharmacal research, 2009, Volume: 32, Issue:7

    Topics: Administration, Oral; Alanine Transaminase; Animals; Anticonvulsants; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Isoenzymes; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Valproic Acid

2009
Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:10

    Topics: Animals; Carbapenems; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Glucuronidase; Humans; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Valproic Acid

2010
Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver.
    European journal of pharmacology, 2013, Dec-05, Volume: 721, Issue:1-3

    Topics: Animals; Diet, High-Fat; Fatty Liver; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hep G2 Cells; Humans; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger; Valproic Acid

2013
Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study.
    Scientific reports, 2014, Mar-12, Volume: 4

    Topics: Animals; Area Under Curve; Brain Chemistry; Drug Evaluation, Preclinical; Food-Drug Interactions; gamma-Aminobutyric Acid; Glucuronosyltransferase; Glycine max; Isoenzymes; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Valproic Acid

2014
In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs.
    Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:2

    Topics: Administration, Intravenous; Animals; Carbapenems; Cytosol; Dogs; Drug Interactions; Enzyme Inhibitors; Hydrolysis; Kidney; Liver; Male; Meropenem; Peptide Hydrolases; Protease Inhibitors; Thienamycins; Valproic Acid

2016
Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase.
    Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:4

    Topics: Binding, Competitive; Carbapenems; Humans; Models, Molecular; Molecular Structure; Peptide Hydrolases; Valproic Acid

2017