valproic acid and trimethadione

valproic acid has been researched along with trimethadione in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (65.85)	18.7374
1990's	2 (4.88)	18.2507
2000's	7 (17.07)	29.6817
2010's	5 (12.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Park, JY; Park, MS; Sharma, G	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Baker, MT; Mishra, RK	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bohlen, N; Hertl, M	1
Araki, Y; Ueki, S; Watanabe, S	1
Hori, M; Ito, T; Shimizu, M; Yoshida, K	3
Göbel, W; Löscher, W	1
Frey, HH; Löscher, W	2
Bigler, ED; Fleming, DE; Shearer, DE	1
Cennamo, M; Piccione, E; Ticconi, C	1
Maitre, M; Vayer, P	1
Bender, AS; Hertz, L	1
Wallace, SJ	1
Lee, EK; Walters, JR; Waszczak, BL	1
Nau, H	1
Charlier, B; Maitre, M; Mandel, P; Vayer, P	1
Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM	1
Bruni, J; Wilder, BJ	1
Ito, K; Murata, T; Nioka, M; Owada, E; Sato, J	1
Bearden, LJ; Snead, OC	1
Cordero, JF; Oakley, GP	1
Friis, ML	1
Albright, PS; Bruni, J	1
Chattha, AS; Fromm, GH; Glass, JD; Martinez, AJ; Silverman, M	1
Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W	1
Katz, RJ; Schmaltz, K	1
Beckman, DL; Crittenden, DJ	1
Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T	1
Kelly, KM; Macdonald, RL	1
Collins, JJ; Evason, K; Huang, C; Hughes, S; Kornfeld, K	1

Reviews

7 review(s) available for valproic acid and trimethadione

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Problems of neurological drug therapy in pregnancy]. La Clinica terapeutica, 1989, Apr-30, Volume: 129, Issue:2 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; Female; Fetus; Haloperidol; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione; Valproic Acid	1989
Use of ethosuximide and valproate in the treatment of epilepsy. Neurologic clinics, 1986, Volume: 4, Issue:3 Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Status Epilepticus; Succinimides; Trimethadione; Valproic Acid	1986
Pharmacokinetics of anti-epileptic drugs in the dog: a review. Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3 Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; Epilepsy; Ethosuximide; Kinetics; Phenobarbital; Phenytoin; Primidone; Species Specificity; Trimethadione; Valproic Acid	1985
Drug exposure during pregnancy: some epidemiologic considerations. Clinical obstetrics and gynecology, 1983, Volume: 26, Issue:2 Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; Epidemiologic Methods; Female; Humans; Hydantoins; Immunosuppressive Agents; Lithium; Lithium Carbonate; Phenothiazines; Pregnancy; Pyridoxine; Registries; Risk; Rubella Vaccine; Solvents; Spermatocidal Agents; Trimethadione; Valproic Acid	1983
The clinical pharmacology of antiepileptic drugs. Clinical neuropharmacology, 1984, Volume: 7, Issue:1 Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Half-Life; Humans; Intestinal Absorption; Kidney; Kidney Diseases; Kinetics; Liver Diseases; Phenobarbital; Phenytoin; Pregnancy; Primidone; Protein Binding; Tissue Distribution; Trimethadione; Valproic Acid	1984
Antiepileptic drug mechanisms of action. Epilepsia, 1995, Volume: 36 Suppl 2 Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calcium Channels; Carbamazepine; Central Nervous System; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Phenytoin; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium Channels; Triazines; Trimethadione; Valproic Acid; Vigabatrin	1995

Other Studies

34 other study(ies) available for valproic acid and trimethadione

Article	Year
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 Topics: Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Drug Design; Electroshock; Male; Mice; Molecular Structure; Oxazepines; Pentylenetetrazole; Seizures	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model. Bioorganic & medicinal chemistry letters, 2014, Dec-01, Volume: 24, Issue:23 Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Performance; Seizures; Thymol	2014
[Adverse effects of anti-epileptic drugs]. Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38 Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid	1975
Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations. Japanese journal of pharmacology, 1977, Volume: 27, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nitrazepam; Olfactory Bulb; Phenobarbital; Phenylacetates; Phenytoin; Trimethadione; Urea; Valproic Acid	1977
Effect of anticonvulsants on thalamic afterdischarge in rats and cats. Japanese journal of pharmacology, 1977, Volume: 27, Issue:6 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Male; Phenobarbital; Phenytoin; Rats; Thalamus; Trimethadione; Valproic Acid	1977
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen. Epilepsia, 1978, Volume: 19, Issue:5 Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid	1978
Effect of anticonvulsants on spiking activity induced by cortical freezing in cats. Epilepsia, 1979, Volume: 20, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Arousal; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Freezing; Gallamine Triethiodide; Immobilization; Male; Phenobarbital; Phenytoin; Taurine; Trimethadione; Valproic Acid; Visual Cortex	1979
Effect of anticonvulsants on cortical focal seizure in cats. Epilepsia, 1977, Volume: 18, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epilepsies, Partial; Female; Heart; Male; Phenobarbital; Phenytoin; Seizures; Trimethadione; Valproic Acid	1977
Di-n-propylacetic acid--profile of anticonvulsant activity in mice. Arzneimittel-Forschung, 1976, Volume: 26, Issue:2 Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid	1976
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy. Epilepsia, 1976, Volume: 17, Issue:4 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pentylenetetrazole; Phenytoin; Rats; Sodium Chloride; Trimethadione; Valproic Acid	1976
Gamma-hydroxybutyrate stimulation of the formation of cyclic GMP and inositol phosphates in rat hippocampal slices. Journal of neurochemistry, 1989, Volume: 52, Issue:5 Topics: Animals; Cyclic GMP; Ethosuximide; Hippocampus; Hydroxybutyrates; Inositol Phosphates; Kinetics; Nalorphine; Naloxone; Pentazocine; Rats; Rats, Inbred Strains; Sodium Oxybate; Sugar Phosphates; Trimethadione; Valproic Acid	1989
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs. Life sciences, 1988, Volume: 43, Issue:6 Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid	1988
Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2 Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Ethosuximide; Male; Neurons; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Substantia Nigra; Trimethadione; Valproic Acid	1986
Species differences in pharmacokinetics and drug teratogenesis. Environmental health perspectives, 1986, Volume: 70 Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Cricetinae; Female; Half-Life; Haplorhini; Humans; Kinetics; Maternal-Fetal Exchange; Metabolic Clearance Rate; Mice; Placenta; Pregnancy; Rabbits; Rats; Species Specificity; Teratogens; Tissue Distribution; Trimethadione; Valproic Acid	1986
Effect of anticonvulsant drugs on gamma-hydroxybutyrate release from hippocampal slices: inhibition by valproate and ethosuximide. Journal of neurochemistry, 1987, Volume: 49, Issue:4 Topics: Animals; Ethosuximide; Hippocampus; Hydroxybutyrates; Pentobarbital; Potassium; Rats; Rats, Inbred Strains; Sodium Oxybate; Trimethadione; Valproic Acid; Verapamil; Veratridine	1987
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. Arzneimittel-Forschung, 1985, Volume: 35, Issue:2 Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Ethosuximide; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Trimethadione; Valproic Acid	1985
Mechanisms of action of antiepileptic drugs. Clinical neuropharmacology, 1982, Volume: 5, Issue:1 Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chemical Phenomena; Chemistry; Humans; Paraldehyde; Phenytoin; Primidone; Seizures; Succinimides; Trimethadione; Valproic Acid	1982
Effect of acetazolamide on the anticonvulsant potency of several antiepileptic drugs in mice. Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:5 Topics: Acetazolamide; Animals; Anticonvulsants; Barbital; Barbiturates; Brain; Drug Interactions; Male; Mephobarbital; Mice; Phenytoin; Time Factors; Trimethadione; Valproic Acid	1983
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. Science (New York, N.Y.), 1980, Nov-28, Volume: 210, Issue:4473 Topics: Animals; Anticonvulsants; Disease Models, Animal; Endorphins; Enkephalins; Epilepsy, Absence; Ethosuximide; Male; Rats; Receptors, Opioid; Seizures; Trimethadione; Valproic Acid	1980
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled? Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Oxazoles; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Risk; Trimethadione; Valproic Acid	1983
Antiabsence drugs and inhibitory pathways. Neurology, 1980, Volume: 30, Issue:2 Topics: Animals; Anticonvulsants; Cats; Cerebral Ventricles; Epilepsy, Absence; Ethosuximide; Imipramine; Neural Inhibition; Neural Pathways; Trimethadione; Valproic Acid	1980
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid. Epilepsia, 1981, Volume: 22, Issue:4 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid	1981
Behavioral interactions between opiate and antiepileptic drugs in the mouse. Neuropharmacology, 1981, Volume: 20, Issue:4 Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Enkephalins; Male; Mice; Morphine; Narcotics; Taurine; Time Factors; Trimethadione; Valproic Acid	1981
Protection from oxygen-induced seizures by clonazepam and propylene glycol. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 168, Issue:1 Topics: Animals; Benzodiazepinones; Carbamazepine; Cats; Clonazepam; Hyperbaric Oxygenation; Polyethylene Glycols; Propylene Glycol; Propylene Glycols; Seizures; Trimethadione; Valproic Acid	1981
Effect of antiepileptic drugs on absence-like seizures in the tremor rat. Epilepsia, 1995, Volume: 36, Issue:9 Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Injections, Intraperitoneal; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Seizures; Time Factors; Trimethadione; Valproic Acid	1995
Valproic acid extends Caenorhabditis elegans lifespan. Aging cell, 2008, Volume: 7, Issue:3 Topics: Animals; Caenorhabditis elegans; Dose-Response Relationship, Drug; Ethosuximide; Longevity; Models, Animal; Time Factors; Trimethadione; Valproic Acid	2008