valproic acid has been researched along with trichostatin a in 166 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 64 (38.55) | 29.6817 |
| 2010's | 94 (56.63) | 24.3611 |
| 2020's | 8 (4.82) | 2.80 |
| Authors | Studies |
|---|---|
| Burnett, R; Gottesfeld, JM; Herman, D; Jenssen, K; Perlman, SL; Soragni, E | 1 |
| Bowes, AJ; Capretta, A; Gerritsma, D; Shi, Y; Werstuck, GH | 1 |
| Bitterman, PB; Huo, Y; Mahmud, SA; Slungaard, A; Wang, J | 1 |
| Bora-Tatar, G; Dalkara, S; Dayangaç-Erden, D; Demir, AS; Erdem-Yurter, H; Yelekçi, K | 1 |
| Corey, DR; Sakurai, F; Yu, D | 1 |
| Forgione, M; Hailu, GS; Mai, A; Robaa, D; Rotili, D; Sippl, W | 1 |
| Brindisi, M; Brogi, S; Butini, S; Campiani, G; Gemma, S; Saraswati, AP | 1 |
| Abd El-Hafeez, AA; Abdelhamid, D; Abuo-Rahma, GEA; Ghosh, P; Hayallah, AM; Katkar, GD; Mostafa, YA; Mustafa, M | 1 |
| Qiu, X; Tan, Y; Wan, L; Wang, H; Yang, L; Yang, Z; Zhu, L | 1 |
| Alfano, AI; Barone, S; Brindisi, M; Cassese, E; Summa, V | 1 |
| Akel, S; Kollia, P; Loukopoulos, D; Marianna, P; Papassotiriou, Y; Stamoulakatou, A | 1 |
| Guenther, MG; Huang, EY; Klein, PS; Lazar, MA; Phiel, CJ; Zhang, F | 1 |
| Böcker, U; Gerhard Ottmann, O; Hoelzer, D; Kalina, U; Koschmieder, S; Koyama, N; Nürnberger, H; Tyagi, S; Wagner, S | 1 |
| Cheng, L; Harwood, AJ; Mudge, AW; Williams, RS | 1 |
| Cossu, G; Iezzi, S; Nervi, C; Puri, PL; Sartorelli, V | 1 |
| Chen, Y; Costa, E; Costa, RH; Grayson, DR; Sharma, RP | 1 |
| Bach, I; Brill, B; Golebiewski, M; Göttlicher, M; Groner, B; Heinzel, T; Krämer, OH; Ostendorff, HP; Peters, MA; Tiefenbach, J; Zhu, P | 1 |
| Hemmerlein, B; Ringert, RH; Schweyer, S; Seseke, F; Thelen, P; Wuttke, W | 1 |
| Desmond, JC; Gui, D; Koeffler, HP; Kumagai, T; Miyakawa, I; Said, JW; Takai, N; Whittaker, S | 1 |
| Chung, YL; Wang, AJ; Yao, LF | 1 |
| McGarry, LC; Ozanne, BW; Winnie, JN | 1 |
| Ballarini, M; Facchetti, F; La Porta, CA; Minucci, S; Perego, P; Previdi, S | 1 |
| Altar, CA; Drabik, CE; Laeng, P; Lemire, AL; Mallon, BS; Pitts, RL; Tang, H; Thyagarajan, R; Weiner, A | 1 |
| Bradel-Tretheway, B; Chakraborty-Sett, S; Dewhurst, S; Fan, S; Maguire, CA; Ramirez, SH; Sapinoro, R; Sui, Z | 1 |
| Benes, V; Brand, H; Denger, S; Gannon, F; Ibberson, D; Ivacevic, T; Lin, CY; Liu, ET; Métivier, R; Reid, G | 1 |
| Berman, MG; Gentleman, RC; Green, JB; Gurvich, N; Klein, PS; Wittner, BS | 1 |
| Bae, YC; Cho, HH; Jung, JS; Kim, YJ; Park, HT; Suh, KT | 1 |
| Bradbury, CA; Bunce, CM; Craddock, C; Drayson, MT; Hayden, R; Khanim, FL; Turner, BM; White, DA | 1 |
| Broccia, ML; Di Renzo, F; Giavini, E; Massa, V; Menegola, E; Minucci, S; Prudenziati, M | 1 |
| Du, GH; Liu, AL; Long, J; Wang, N | 1 |
| Schroeder, TM; Westendorf, JJ | 1 |
| Bicaku, E; Daud, AI; Marchion, DC; Munster, PN; Sullivan, DM; Turner, JG | 1 |
| Fu, RY; Li, FY; Liu, H; Mao, YQ; Wang, XY; Wu, XZ; Zhou, CY; Zhu, YP | 1 |
| Chow, C; Kim, Y; Pommier, YG; Simons, SS; Sun, Y | 1 |
| Ciccarelli, C; Giampaolo, A; Giampiero, M; Hassan, HJ; Marampon, F; Mattia, G; Milazzo, L; Pascuccio, M; Vulcano, F; Zani, BM | 1 |
| Qi, H; Ratnam, M | 1 |
| Chuang, DM; Leng, Y | 1 |
| Adami, R; Bottinelli, R; Capogrossi, MC; Colussi, C; Di Padova, M; Fortuni, S; Gaetano, C; Gallinari, P; Illi, B; Minetti, GC; Mozzetta, C; Parente, V; Puri, PL; Sampaolesi, M; Sartorelli, V; Serra, C; Steinkühler, C; Straino, S | 1 |
| Bae, MK; Jeong, JW; Jung, BK; Kim, KW; Kim, SH; Lee, JW; Park, JA; Seo, JH | 1 |
| Broccia, ML; Cappelletti, G; Di Renzo, F; Giavini, E; Menegola, E | 1 |
| Chen, PS; Chuang, DM; Hong, JS; Kim, HJ; Ren, M; Rowe, M | 1 |
| Guo, SW; Wu, Y | 1 |
| Smetana, K; Starková, J; Trka, J; Zápotocký, M | 1 |
| Alam, HB; Chen, H; Kirkpatrick, J; Koustova, E; Li, Y; Lin, T; Liu, B; Rhee, P; Sailhamer, EA; Shults, C | 1 |
| Cassell, M; Lindsay, DS; Mitchell, SM; Reilly, CM; Strobl, JS | 1 |
| Chen, WY; Chung, BC; Huang, CC; Weng, JH | 1 |
| Bruserud, Ø; Corbascio, M; Eide, GE; Gjertsen, BT; Hatfield, K; Kalland, KH; Ryningen, A; Stapnes, C; Øyan, AM | 1 |
| Gregorie, CJ; Khan, AN; Tomasi, TB | 1 |
| Mitani, K; Sasaki, K; Yamagata, T | 1 |
| Hyttinen, JM; Kaarniranta, K; Kyrylenko, S; Ojala, J; Salminen, A; Suuronen, T; Thornell, A | 1 |
| Countryman, JK; Gradoville, L; Miller, G | 1 |
| Brown, SL; Kim, JH; Kolozsvary, A; Liu, J; Ryu, S | 1 |
| Europe-Finner, GN; Hehir, MP; Morrison, JJ; Moynihan, AT; Robson, SC; Sharkey, AM | 1 |
| Czapp, M; Hoffmann, K; Löscher, W | 1 |
| Jawed, S; Kim, B; Niles, LP; Rincón Castro, LM | 1 |
| Adès, L; Boehrer, S; de Botton, S; Fabre, C; Fenaux, P; Grosjean, J; Kroemer, G; Perfettini, JL; Tailler, M | 1 |
| Haumaitre, C; Lenoir, O; Scharfmann, R | 1 |
| Azzi, A; Cosseau, C; Grunau, C | 1 |
| Blake, KR; Cowell, RM; Meador-Woodruff, JH; Russell, JW; Talati, P | 1 |
| Chase, K; Gavin, DP; Jayaraman, S; Kartan, S; Sharma, RP | 1 |
| Slattery, EL; Speck, JD; Warchol, ME | 1 |
| Arimochi, H; Gotohda, T; Her, S; Lee, MS; Morita, K | 1 |
| Duque-Afonso, J; Hauswald, S; Keller, U; Licht, T; Lübbert, M; Peschel, C; Schertl, FM; Wagner, MM | 1 |
| Baccino, FM; Bonelli, G; Bonetto, A; Costelli, P; Minero, VG; Penna, F; Reffo, P | 1 |
| Caby, S; Capron, M; Cosseau, C; Dissous, C; Dubois, F; Grunau, C; Oger, F; Pierce, RJ | 1 |
| Ha, H; Kim, YO; Lee, HB; Noh, H; Oh, EY; Seo, JY; Yu, MR | 1 |
| Fu, L; Wang, XX | 1 |
| Dedes, KJ; Fedier, A; Fink, D; Furlato, M; Imesch, P | 1 |
| Chiang, AK; Hui, KF | 1 |
| Jia, S; Li, X; Meng, A; Wang, S; Wang, Y | 1 |
| Chagnac, A; Freidkin, I; Gafter, U; Herman, M; Korzets, A; Ori, Y; Tobar, A | 1 |
| Barbano, PE; Cao, Y; Coifman, R; Lee, SH; Semanchik, N; Somlo, S; Sun, Z | 1 |
| Jiang, J; Liu, XS; Peng, CY; Zheng, HT | 1 |
| Füllgrabe, J; Hajji, N; Hermanson, O; Joseph, B; Vlachos, P; Wallenborg, K | 1 |
| Atala, A; Hodges, SJ; Mishra, N; Yoo, JJ | 1 |
| Clark, IM; Culley, KL; Illman, SA; Kevorkian, L; Lohi, J; Parker, AE; Swingler, TE; Young, DA | 1 |
| Choi, N; Choi, S; Khattar, P; Lee, SC; Suh, HS | 1 |
| Chen, J; Ghazawi, FM; Li, Q | 1 |
| Broad, KD; Emson, PC; Keverne, EB; Xia, J | 1 |
| Costa-Borges, N; Ibáñez, E; Santaló, J | 1 |
| Ji, P; Lodish, HF; Murata-Hori, M; Ramirez, T; Yeh, V | 1 |
| Baker, E; Bayles, R; Eikelis, N; El-Osta, A; Lambert, G | 1 |
| Clark, OH; Duh, QY; Griff, NJ; Grogan, RH; Kebebew, E; Mitmaker, EJ; Sarkar, R; Shen, WT | 1 |
| Abbate, A; Bogaard, HJ; Hussaini, AA; Kasper, M; Kraskauskas, D; Mizuno, S; Natarajan, R; Toldo, S; Voelkel, NF | 1 |
| Biermann, J; Boyle, J; Lagrèze, WA; Pielen, A | 1 |
| Gao, F; Jin, Y; Shi, G | 1 |
| Berenzon, D; Chaurasia, P; Hoffman, R | 1 |
| Ahn, KS; Kim, M; Kim, YJ; Shim, H | 1 |
| Dencker, L; Forsberg, M; Gustafson, AL; Jergil, M; Salter, H; Stigson, M; Stockling, K | 1 |
| Bhat, GK; Fortson, WS; Fujimura, Y; Grizzle, WE; Kayarthodi, S; Matthews, R; Rao, VN; Reddy, ES; Xu, H | 1 |
| Cloyd, MW; Sahu, GK | 1 |
| Bhide, PG; Crandall, JE; Dräger, UC; Duester, G; Goodman, T; McCaffery, P; McCarthy, DM | 1 |
| Carneiro, K; Lemire, JM; Levin, M; Tseng, AS | 1 |
| Agapova, OA; Bowcock, AM; Harbour, JW; Kneass, ZT; Landreville, S; Lee, RS; Matatall, KA; Onken, MD | 1 |
| Dvorakova, M; Eckschlager, T; Frei, E; Göttlicherova, M; Hrabeta, J; Hrebackova, J; Kizek, R; Kopejtkova, B; Moserova, M; Poljakova, J; Stiborova, M | 1 |
| Brask, J; Hetta, J; Johansson, AS; Lundkvist, GB; Owe-Larsson, B | 1 |
| Cooper, PR; Duncan, HF; Fleming, GJ; Smith, AJ | 2 |
| Huang, GB; Lu, KH; Lu, SS; Luo, J; Ning, SF; Qin, ZX | 1 |
| Chiaratti, MR; de Araújo, RR; De Bem, TH; Meirelles, FV; Oliveira, Lde J; Perecin, F; Sangalli, JR; Smith, LC; Valim Pimentel, JR | 1 |
| Gupta, V; Halsall, J; Nightingale, KP; O'Neill, LP; Turner, BM | 1 |
| Balmer, NV; Chambers, SM; Hescheler, J; Ivanova, VN; Jagtap, S; Leist, M; Nikolaeva, E; Sachinidis, A; Waldmann, T; Weng, MK; Zimmer, B | 1 |
| Jasek, E; Jasinska, M; Jurkowska, H; Lis, GJ; Litwin, JA | 1 |
| Deng, L; Gan, L; Ge, Y; Jiang, W; Liu, Y; Ni, PY; Sun, CY; Wu, SS; Xiao, YF; Xin, HB; Zhang, W | 1 |
| Cogdill, AP; Cooper, ZA; Ferrone, CR; Fiedler, A; Frederick, DT; Garber, HR; Rosenberg, L; Thayer, SP; Wargo, JA; Warshaw, AL | 1 |
| Capogrossi, MC; Castellano, S; Colussi, C; Farsetti, A; Gaetano, C; Illi, B; Mai, A; Mattiussi, S; Rosati, J; Sbardella, G; Scopece, A; Spallotta, F; Vitale, S | 1 |
| Bitman, M; Dvorak, Z; Pavek, P; Vrzal, R | 1 |
| Baraty, C; Bianco, C; Castro, NP; Gonzales, M; Held, N; Karasawa, H; Rangel, MC; Rollman, K; Salomon, DS; Strizzi, L | 1 |
| Blythe, SA; Fass, DM; Haggarty, SJ; Klein, PS; Koniski, A; Palis, J; Shah, RR; Shinde, M | 1 |
| Katiyar, SK; Prasad, R; Singh, T | 1 |
| Dalli, J; Montero-Melendez, T; Perretti, M | 1 |
| Ali, MF; Chachadi, VB; Cheng, PW | 1 |
| Cha, JJ; Chang, KT; Choi, SA; Huh, JW; Jeong, KJ; Kim, JS; Kim, SH; Kim, SU; Kim, YH; Lee, SR; Sim, BW; Song, BS; Yoon, SB | 1 |
| Held, G; Kaddu-Mulindwa, D; Kubuschok, B; Neumann, F; Pfreundschuh, M; Preuss, KD; Roemer, K; Widmann, T; Zwick, C | 1 |
| Geers, C; Mannaerts, I; Pauwels, M; Van Beneden, K; Van den Branden, C; van Grunsven, LA; Wissing, KM | 1 |
| Fujiki, R; Fujitani, M; Sato, A; Yamashita, T | 1 |
| Choi, SJ; Eun, HC; Jo, SJ; Kim, KH; Kwon, O; Lee, JY; Park, PJ; Park, WS; Yoon, SY | 1 |
| An, L; Jaime-Frias, R; Kadiyala, V; Mathieu, W; Patrick, NM; Pookhao, N; Smith, CL | 1 |
| Dargatz, H; Fahr, A; Heinzel, T; Hennig, D; Imhof, D; Kostenis, E; Schubert, S; Schubert, US | 1 |
| Araki, K; Matsushita, Y; Mukae, T; Omotuyi, Oi; Ueda, H | 1 |
| Dolan-Evans, E; Leanage, G; Moldrich, RX; Nelson, M; Reutens, DC; Reza, N; She, D | 1 |
| Gacek, A; Rychli, K; Strauss, J; Sulyok, M; Wagner, M; Zutz, C | 1 |
| Bezdecny, S; Chandwani, S; Ehrlich, ME; Keilani, S; Morant, A; Ortiz-Virumbrales, M | 1 |
| Araki, H; Baluchamy, S; Lavelle, D; Li, X; Mahmud, N; Petro, B; Quigley, JG; Suphangul, M; Taioli, S | 1 |
| Komandirov, MA; Sharifulina, SA; Uzdensky, AB | 1 |
| Bezecny, P | 1 |
| Alvarez, AA; Bushnev, S; Field, M; Longo, MS; Sugaya, K | 1 |
| Kaminska, B; Maleszewska, M; Steranka, A | 1 |
| Felisbino, MB; Gatti, MS; Mello, ML | 1 |
| Balmer, NV; Berthold, MR; Hengstler, JG; Henry, M; Ivanova, VN; Klima, S; Kolde, R; Leist, M; Meganathan, K; Rahnenführer, J; Rempel, E; Sachinidis, A; Waldmann, T; Weng, MK | 1 |
| Keum, G; Kowall, NW; Lee, J; Ryu, H; Yoon, YJ | 1 |
| Alsarraf, O; Chou, CJ; Crosson, CE; Dahrouj, M; Fan, J; Menick, DR | 1 |
| Li, B; Li, D; Liu, Z; Qiu, F; Wei, G; Zhang, L; Zhang, Y; Zhu, R; Zuo, Q | 1 |
| Ayllon, V; Bueno, C; Cobo, M; Guerrero-Carreno, X; Lamolda, M; Martin, F; Menendez, P; Navarro-Montero, O; Ramos-Mejia, V; Real, PJ; Romero, T; Toscano, MG | 1 |
| Futani, H; Kato-Kogoe, N; Kawabe, M; Kishimoto, H; Nakasho, K; Nishiura, H; Yamada, N; Yamanegi, K; Yoshiya, S | 1 |
| Guo, X; Li, L; Ruan, H; Shen, W; Tao, Y | 1 |
| Ji, M; Kim, DS; Kim, KB; Kim, Y; Lee, EJ; Lee, SJ; Park, SM; Sung, R | 1 |
| Hoffman, R; Iancu-Rubin, C | 1 |
| Ng, YK; Ong, WY; Tan, CS | 1 |
| Goes, FS; Ishizuka, K; Kano, S; Koga, M; Kondo, MA; Obie, C; Passeri, E; Primerano, A; Rapoport, JL; Sawa, A; Sengupta, S; Srivastava, R; Valle, D; Wilson, AM; Zandi, PP | 1 |
| Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H | 1 |
| Li, Y; Ma, L; Mulholland, MW; Tang, H; Yin, Y; Yu, R; Zhang, W; Zhao, J | 1 |
| Chen, N; Dai, Q; Du, YL; Hao, X; He, LQ; Liu, J; Tan, Y; Wang, WM; Ying, J | 1 |
| Bernard, L; Bonneton, F; Chen, XY; Laudet, V; Li, L; Tohme, M | 1 |
| Adachi, T; Hara, H; Kamiya, T; Kano, A; Nonomura, S | 1 |
| Doll, M; Hrgovic, I; Kaufmann, R; Kippenberger, S; Meissner, M; Pinter, A | 1 |
| Chan, LC; Chan, YF; Lam, YM; Ng, RK | 1 |
| Andrade, R; Aréchaga, J; Arluzea, J; De Wever, O; Díaz-Núñez, M; Díez-Torre, A; Silió, M | 1 |
| Andrews, B; Ang, JS; Boerkoel, CF; Duffy, S; Fam, HK; Hieter, P; Kim, JH; Larionov, V; Shah, SP; Singh, T; Styles, EB; Wang, YK | 1 |
| Hayakawa, T; Katagiri, C; Kondo, T; Matsushita, M; Nakamura, W; Nakamura-Higa, M; Shimizu-Okabe, C; Takamatsu, G; Takayama, C; Tomoyuki, T; Wakabayashi, S | 1 |
| Cirone, M; D'Orazi, G; Del Porto, P; Faggioni, A; Gilardini Montani, MS; Granato, M; Merendino, N; Santoni, C | 1 |
| Cooper, P; Duncan, H; He, W; He, X; Liu, B; Liu, N; Luo, Z; Ma, F; Sun, L; Wang, J; Wang, Z | 1 |
| Eid, A; Green, AL; Guo, GL; Richardson, JR; Zarbl, H; Zhan, L | 1 |
| Huang, C; Li, J; Liang, H; Liu, Y; Ma, T; Meng, X; Xu, Q; Yang, Y; Ye, M | 1 |
| Carroll, TD; Chen, Y; Langlands, AJ; Näthke, I | 1 |
| Yamato, E | 1 |
| Barra, F; Ferrero, S | 1 |
| Bunpetch, V; Chen, X; Lin, J; Ouyang, H; Tu, W; Yang, L; Yuan, C; Zhang, C; Zhang, E | 1 |
| Ji, M; Lee, EJ; Park, SM; Wang, JH | 1 |
| Cao, P; Chang, Y; Yang, L | 1 |
| Fan, L; Jiang, T; Qiu, X; Yin, Y; Zhu, Q | 1 |
| Lu, Y; Qiu, X; Rong, X; Yang, J | 1 |
| Ge, C; He, C; Hu, B; Huang, C; Jiang, W; Ma, T; Tang, Q; Xu, C; Yuan, X; Zhu, H | 1 |
| Hartung, EE; Mukhtar, SZ; Niles, LP; Shah, SM | 1 |
| Bambery, KR; Karagiannis, TC; Licciardi, PV; Mazarakis, N; Royce, SG; Samuel, CS; Snibson, KJ; Tobin, MJ; Ververis, K; Vongsvivut, J | 1 |
| Koch, BEV; Meijer, AH; Spaink, HP | 1 |
8 review(s) available for valproic acid and trichostatin a
| Article | Year |
|---|---|
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Topics: Animals; Antiparasitic Agents; Drug Repositioning; Helminth Proteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Leishmania; Plasmodium; Protozoan Proteins; Schistosoma; Toxoplasma; Trypanosoma | 2017 |
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.
Topics: Biological Products; Drug Design; Drug Discovery; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Structure | 2021 |
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Histone Deacetylase 6; Humans; Signal Transduction | 2022 |
[A new target of cancer therapy: advances in the study of histone deacetylase].
Topics: Acetylation; Animals; Apoptosis; Benzamides; Drug Delivery Systems; Enzyme Inhibitors; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasms; Peptides; Pyridines; Valproic Acid | 2005 |
[Recent advances in DNA demethylation in tumor therapy].
Topics: Animals; Cytidine; DNA Methylation; DNA Modification Methylases; Gene Knockout Techniques; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasms; RNA Interference; Valproic Acid | 2009 |
Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience.
Topics: Animals; Brain Neoplasms; Clinical Trials as Topic; Depsipeptides; Epigenesis, Genetic; Glioblastoma; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Valproic Acid; Vorinostat | 2014 |
Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS).
Topics: Amyotrophic Lateral Sclerosis; Animals; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Motor Neurons; Superoxide Dismutase; Superoxide Dismutase-1; Valproic Acid | 2014 |
Role of epigenetic reprogramming in hematopoietic stem cell function.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Proliferation; Cellular Reprogramming; Chromatin; Cytokines; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Lithium Chloride; Valproic Acid | 2015 |
2 trial(s) available for valproic acid and trichostatin a
| Article | Year |
|---|---|
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
Topics: Acetylation; Cells, Cultured; E-Selectin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipopolysaccharides; Monocytes; NF-kappa B; Protein Binding; Response Elements; RNA, Messenger; RNA, Small Interfering; Thromboplastin; Thrombosis; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2007 |
Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle.
Topics: Acetylation; Animals; Azacitidine; Cattle; Cell Nucleus; Cells, Cultured; Chromatin Assembly and Disassembly; Cloning, Organism; Decitabine; Embryonic Development; Female; Histone Deacetylase Inhibitors; Histones; Hydralazine; Hydroxamic Acids; Nuclear Transfer Techniques; Pregnancy; Term Birth; Up-Regulation; Valproic Acid; Zygote | 2012 |
156 other study(ies) available for valproic acid and trichostatin a
| Article | Year |
|---|---|
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
Topics: Acetylation; Alleles; Anilides; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Frataxin; Friedreich Ataxia; Gene Expression Regulation; Gene Silencing; HeLa Cells; Heterochromatin; Histone Deacetylase Inhibitors; Histones; Humans; Iron-Binding Proteins; Molecular Structure; RNA, Messenger; Transcription, Genetic | 2006 |
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition.
Topics: Cell Line; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Histones; Humans; Molecular Chaperones; Molecular Structure; Structure-Activity Relationship; Valproic Acid | 2007 |
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Topics: Caffeic Acids; Carboxylic Acids; Catalytic Domain; Chlorogenic Acid; Curcumin; Enzyme Inhibitors; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Structure; Protein Binding | 2009 |
Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression.
Topics: Clone Cells; Epigenesis, Genetic; Fibroblasts; Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2; Molecular Structure; Mutation; Organic Chemicals; Polymerase Chain Reaction; Rett Syndrome; RNA, Messenger; Stereoisomerism | 2011 |
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.
Topics: Animals; Biomarkers; Cell Line; Epigenesis, Genetic; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Humans; Mice; Protein Processing, Post-Translational; Rare Diseases | 2020 |
A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Focal Adhesion Kinase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2021 |
Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures.
Topics: Antifungal Agents; beta-Thalassemia; Cells, Cultured; Drug Interactions; Erythroid Precursor Cells; GABA Agents; Gene Expression; Globins; Hemin; Humans; Hydroxamic Acids; Valproic Acid | 2001 |
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
Topics: Acetylation; Animals; Anticonvulsants; Antimanic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Lithium; Luminescent Proteins; Plasmids; Promoter Regions, Genetic; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction; Teratogens; Time Factors; Transcription, Genetic; Transfection; Valproic Acid; Wnt Proteins; Xenopus; Zebrafish Proteins | 2001 |
Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells.
Topics: Blotting, Northern; Blotting, Western; Butyrates; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Enzyme Inhibitors; Gene Expression; Growth Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interleukin-18; Leukemia, Erythroblastic, Acute; Myeloid Cells; Promoter Regions, Genetic; RNA, Messenger; U937 Cells; Valproic Acid | 2002 |
A common mechanism of action for three mood-stabilizing drugs.
Topics: Animals; Animals, Newborn; Antimanic Agents; Bipolar Disorder; Calcium-Calmodulin-Dependent Protein Kinases; Carbamazepine; Cell Aggregation; Chemotaxis; Dictyostelium; Ganglia, Spinal; Genes, Protozoan; Glycogen Synthase Kinases; Growth Cones; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inositol 1,4,5-Trisphosphate; Lithium; Mice; Mutation; Neurons, Afferent; Rats; Signal Transduction; Valproic Acid | 2002 |
Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.
Topics: Acetylation; Acetyltransferases; Animals; beta-Galactosidase; Butyrates; Cell Nucleus; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Genes, Reporter; Humans; Hydroxamic Acids; Kinetics; Mice; Muscle, Skeletal; Pregnancy; Prenatal Exposure Delayed Effects; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Valproic Acid | 2002 |
On the epigenetic regulation of the human reelin promoter.
Topics: Base Sequence; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Line; Chromatin; Deoxycytosine Nucleotides; DNA Methylation; Extracellular Matrix Proteins; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Luciferases; Molecular Sequence Data; Nerve Tissue Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tretinoin; Tumor Cells, Cultured; Valproic Acid | 2002 |
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.
Topics: Animals; Base Sequence; Cells, Cultured; Cysteine Endopeptidases; DNA Primers; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Hydrolysis; Hydroxamic Acids; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Ubiquitin; Valproic Acid | 2003 |
Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-3; Transcription Factors; Valproic Acid | 2004 |
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells.
Topics: Agar; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cadherins; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Chromatin; Cyclin D1; Cyclin D2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Dose-Response Relationship, Drug; Endometrial Neoplasms; Enzyme Inhibitors; Female; Flow Cytometry; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; In Situ Nick-End Labeling; Mice; Mice, Nude; Precipitin Tests; Proto-Oncogene Proteins c-bcl-2; S Phase; Sodium Oxybate; Time Factors; Tumor Suppressor Proteins; Valproic Acid; Vorinostat | 2004 |
Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy.
Topics: Acetylation; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; Female; Fibrosis; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Phenylbutyrates; Radiation Injuries; Radiotherapy; Rats; Rats, Sprague-Dawley; Ribonucleases; Skin; Time Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Valproic Acid; Wound Healing | 2004 |
Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes.
Topics: Actins; Animals; Blotting, Northern; Blotting, Western; Cadherin Related Proteins; Cadherins; Cell Division; Cell Line; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Chemotaxis; Cloning, Molecular; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Enzymologic; Histone Deacetylases; Hydroxamic Acids; Microscopy, Confocal; Microscopy, Phase-Contrast; Neoplasm Invasiveness; Oncogene Proteins v-fos; Phenotype; Rats; Repressor Proteins; RNA; STAT6 Transcription Factor; Trans-Activators; Transfection; Valproic Acid | 2004 |
Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Membrane Glycoproteins; Reverse Transcriptase Polymerase Chain Reaction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat | 2004 |
The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells.
Topics: Animals; Astrocytes; bcl-Associated Death Protein; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Cell Count; Cell Differentiation; Cells, Cultured; Cyclin D2; Cyclins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lithium Chloride; Neurons; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Time Factors; Trans-Activators; Tretinoin; Tubulin; Valproic Acid | 2004 |
Valproic acid enhances gene expression from viral gene transfer vectors.
Topics: Adenoviridae; Animals; Dependovirus; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genes, Reporter; Genetic Vectors; Herpesviridae; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Luciferases; Mice; Transformation, Genetic; Valproic Acid | 2005 |
Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A.
Topics: Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Markers; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Kinetics; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Tamoxifen; Transcription, Genetic; Valproic Acid | 2005 |
Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Enzyme Inhibitors; Female; Gene Expression Profiling; Histone Deacetylase Inhibitors; Hydroxamic Acids; Species Specificity; Spinal Dysraphism; Transcription, Genetic; Valproic Acid; Xenopus; Zebrafish | 2005 |
Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mesenchymal Stem Cells; Osteogenesis; Osteopontin; Sialoglycoproteins; Sp7 Transcription Factor; Transcription Factors; Transforming Growth Factor beta; Valproic Acid | 2005 |
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.
Topics: Acetylation; Acute Disease; Adult; Antigens, CD34; Butyrates; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid; Myeloid Cells; Tumor Cells, Cultured; Valproic Acid; Vorinostat | 2005 |
Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity.
Topics: Abnormalities, Drug-Induced; Acetylation; Animals; Bone and Bones; Cartilage; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Mice; Pregnancy; Valproic Acid | 2005 |
Histone deacetylase inhibitors promote osteoblast maturation.
Topics: Acetylation; Alkaline Phosphatase; Animals; Benzamides; Butyric Acid; Calcification, Physiologic; Calcium; Cell Cycle; Cell Differentiation; Cell Line; Cell Shape; Cell Survival; Cells, Cultured; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Integrin-Binding Sialoprotein; Mice; Organ Culture Techniques; Osteoblasts; Osteocalcin; Osteopontin; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Skull; Valproic Acid | 2005 |
Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Butyrates; Chromatin; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Antisense; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Profiling; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mitoxantrone; Neoplasms; Oligonucleotide Array Sequence Analysis; RNA, Small Interfering; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Valproic Acid | 2005 |
[Antineoplastic effect of valproic acid and trichostatin on HL-60 and K562 cells].
Topics: Antineoplastic Agents; Cell Proliferation; Drug Synergism; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Inhibitory Concentration 50; K562 Cells; Valproic Acid | 2005 |
Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.
Topics: Acetylation; Animals; Cell Line; Cell Line, Transformed; Cell Transformation, Viral; Chlorocebus aethiops; Dexamethasone; Dichlororibofuranosylbenzimidazole; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucocorticoids; Hydroxamic Acids; Isoquinolines; Kinetics; Models, Theoretical; Phosphorylation; Plasmids; Receptors, Glucocorticoid; RNA Polymerase II; Trans-Activators; Transcriptional Activation; Transfection; Ubiquitin-Conjugating Enzymes; Valproic Acid | 2006 |
HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers.
Topics: Acetylation; Butadienes; Butyrates; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Integrin beta3; Megakaryocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Membrane Glycoprotein IIb; Promoter Regions, Genetic; Valproic Acid | 2006 |
Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates.
Topics: Acetylation; Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carrier Proteins; CHO Cells; Cricetinae; Drug Synergism; Enzyme Inhibitors; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Promoter Regions, Genetic; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Retinoic Acid; RNA, Messenger; Substrate Specificity; Tetrahydrofolates; Transcription Factor AP-1; Tretinoin; Up-Regulation; Valproic Acid | 2006 |
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.
Topics: Acetylation; alpha-Synuclein; Animals; Anticonvulsants; Antimanic Agents; Cells, Cultured; Cerebellum; Cerebral Cortex; Glutamic Acid; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Neuroprotective Agents; Oligonucleotides, Antisense; Phenylbutyrates; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ubiquitin-Conjugating Enzymes; Valproic Acid | 2006 |
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.
Topics: Animals; Dystrophin; Enzyme Inhibitors; Fibrosis; Follistatin; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscles; Muscular Dystrophy, Animal; Phenylbutyrates; Sarcoglycans; Satellite Cells, Skeletal Muscle; Valproic Acid | 2006 |
Regulation of the HIF-1alpha stability by histone deacetylases.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Mice; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Valproic Acid | 2007 |
Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Blotting, Western; Bone and Bones; Boric Acids; Cell Nucleus; Enzyme Inhibitors; Female; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Kinetics; Male; Mice; Pregnancy; Teratogens; Valproic Acid | 2007 |
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; Butyrates; CD11b Antigen; Cerebral Infarction; Disease Models, Animal; Ectodysplasins; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; HSP70 Heat-Shock Proteins; Hydroxamic Acids; Male; Microglia; Neuroprotective Agents; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Stroke; Tumor Suppressor Protein p53; Valproic Acid | 2007 |
Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Endometrium; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Stromal Cells; Tretinoin; Valproic Acid | 2008 |
Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Leukemia, Myeloid; Protease Inhibitors; Valproic Acid | 2007 |
Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.
Topics: Acetylation; Animals; Enzyme Inhibitors; Gene Expression; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Valproic Acid; Vorinostat | 2007 |
Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro.
Topics: Animals; Antiprotozoal Agents; Butyrates; Cattle; Cell Line; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxylamines; Inhibitory Concentration 50; Niacinamide; Parasitic Sensitivity Tests; Phenylbutyrates; Quinolines; Toxoplasma; Valproic Acid; Vitamin B Complex; Vorinostat | 2007 |
Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1).
Topics: Adrenal Cortex; Animals; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mice; Proteasome Endopeptidase Complex; RNA Interference; SKP Cullin F-Box Protein Ligases; Steroidogenic Factor 1; Steroids; Ubiquitin; Valproic Acid | 2007 |
Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors.
Topics: Adult; Aged; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Profiling; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Male; Middle Aged; Stromal Cells; Sulfonamides; Valproic Acid | 2007 |
Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells.
Topics: Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cysteine Endopeptidases; Enzyme Inhibitors; Epigenesis, Genetic; Flow Cytometry; Histocompatibility Antigens Class I; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melanoma; Membrane Transport Proteins; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2008 |
Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.
Topics: Acetylation; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Core Binding Factor Alpha 2 Subunit; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; K562 Cells; Leukemia; Mutant Chimeric Proteins; Valproic Acid | 2008 |
Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90.
Topics: Acetylation; Animals; Benzoquinones; Cell Line; Dactinomycin; Dehydroepiandrosterone; Diethylstilbestrol; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Estrogens, Non-Steroidal; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Lactams, Macrocyclic; Neurons; Protein Synthesis Inhibitors; Selective Estrogen Receptor Modulators; Signal Transduction; Sirtuin 2; Sirtuins; Transcriptional Activation; Valproic Acid | 2008 |
Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors.
Topics: Acetylation; Animals; Azacitidine; Butyrates; Callithrix; Cell Line; Chromatin Immunoprecipitation; Decitabine; DNA Modification Methylases; DNA, Viral; Enzyme Inhibitors; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Tetradecanoylphorbol Acetate; Valproic Acid; Virus Activation; Virus Latency | 2008 |
Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Hydroxamic Acids; Male; Mice; Mice, Inbred BALB C; Radiation-Protective Agents; Valproic Acid; Whole-Body Irradiation | 2008 |
Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility.
Topics: Adult; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Vitro Techniques; Oxytocics; Oxytocin; Pregnancy; Protein Synthesis Inhibitors; Uterine Contraction; Valproic Acid | 2008 |
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Generalized; Female; Histone Deacetylases; Hydroxamic Acids; Mice; Pentylenetetrazole; Protein Synthesis Inhibitors; Time Factors; Valproic Acid | 2008 |
Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Methyl-CpG-Binding Protein 2; Rats; Receptor, Melatonin, MT1; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Valproic Acid | 2008 |
A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts.
Topics: Azacitidine; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Female; Granulocyte Precursor Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; I-kappa B Kinase; Leukemia, Myeloid, Acute; Male; Middle Aged; NF-kappa B; Valproic Acid | 2008 |
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Lineage; Cell Proliferation; Down-Regulation; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Hydroxamic Acids; Islets of Langerhans; Nerve Tissue Proteins; Pancreas; Pancreas, Exocrine; Pancreatic Ducts; Pancreatic Polypeptide-Secreting Cells; Rats; Rats, Wistar; Stem Cells; Valproic Acid | 2008 |
Schistosoma mansoni: developmental arrest of miracidia treated with histone deacetylase inhibitors.
Topics: Animals; Biomphalaria; Butyrates; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; Larva; Mesocricetus; Metamorphosis, Biological; Schistosoma mansoni; Valproic Acid | 2009 |
Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells.
Topics: Apoptosis; Biological Transport; Caspase 3; Cell Line, Tumor; Enzyme Inhibitors; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Huntington Disease; Hydrogen Peroxide; Hydroxamic Acids; Neuroblastoma; Neurons; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Transcription Factors; Valproic Acid | 2009 |
Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population.
Topics: Acetylation; Adult; Bipolar Disorder; Blotting, Western; Cell Culture Techniques; Enzyme Inhibitors; Female; Gene Expression Regulation; Glutamate Decarboxylase; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lymphocytes; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia; Up-Regulation; Valproic Acid; Young Adult | 2009 |
Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle.
Topics: Animals; Apoptosis; Benzamides; Butyrates; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chickens; Epigenesis, Genetic; Epithelium; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Pyridines; Regeneration; Saccule and Utricle; Valproic Acid | 2009 |
Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells.
Topics: Animals; Brain-Derived Neurotrophic Factor; Butyrates; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; Gene Expression; Glial Fibrillary Acidic Protein; Histone Deacetylase Inhibitors; Hydroxamic Acids; Neuroglia; Rats; RNA, Messenger; Serotonin; Sodium Compounds; Steroids; Time Factors; Valproic Acid | 2009 |
Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.
Topics: Acute Disease; Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Transporters; Biological Transport; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Immunoblotting; K562 Cells; Leukemia, Myeloid; Multidrug Resistance-Associated Proteins; Pharmaceutical Preparations; Phenotype; Phenylbutyrates; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid; Vorinostat | 2009 |
Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.
Topics: Animals; Cachexia; Colonic Neoplasms; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Follistatin; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Muscles; Muscular Atrophy; Myostatin; Neoplasm Transplantation; Ubiquitin-Protein Ligases; Valproic Acid | 2009 |
Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.
Topics: Acetylation; Animals; Apoptosis; Caspase 3; Caspase 7; Chromatin Immunoprecipitation; DNA, Protozoan; Enzyme Inhibitors; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; In Situ Nick-End Labeling; Molecular Sequence Data; Schistosoma mansoni; Sequence Analysis, DNA; Survival Analysis; Up-Regulation; Valproic Acid; Vorinostat | 2009 |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recombinant Proteins; Repressor Proteins; RNA Interference; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid | 2009 |
MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoprecipitation; Valproic Acid; Vorinostat | 2009 |
Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Burkitt Lymphoma; Butyrates; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Survival; Fluorescent Antibody Technique; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia; Polymerase Chain Reaction; Stomach Neoplasms; Valproic Acid; Vorinostat | 2010 |
Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos.
Topics: Acetylation; Animals; Animals, Genetically Modified; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Hematopoiesis; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Situ Hybridization; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Neovascularization, Physiologic; Repressor Proteins; Time Factors; Valproic Acid; Zebrafish; Zebrafish Proteins | 2009 |
Effects of histone deacetylase inhibitors on rat mesangial cells.
Topics: Actins; Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Collagen; Cyclin-Dependent Kinase Inhibitor Proteins; Enzyme Activation; Glomerular Mesangium; Glomerulonephritis, Membranoproliferative; Histone Deacetylase Inhibitors; Hydroxamic Acids; Isoantibodies; Mesangial Cells; Muscle, Smooth; Proteinuria; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Valproic Acid | 2010 |
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.
Topics: Animals; Disease Models, Animal; Gene Knockdown Techniques; Genes, Dominant; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Phenotype; Polycystic Kidney Diseases; Valproic Acid; Zebrafish | 2009 |
Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Drug Antagonism; Drug Synergism; Electrophoresis, Capillary; Growth Inhibitors; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; K562 Cells; Leukemia; Oxides; U937 Cells; Valproic Acid | 2010 |
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
Topics: Acetylation; Animals; Cell Death; Cell Line, Tumor; DNA Damage; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Male; Neoplasms; Sirtuin 1; Topoisomerase II Inhibitors; Valproic Acid | 2010 |
The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study.
Topics: Azacitidine; Cells, Cultured; Collagen; Epigenesis, Genetic; Genetic Therapy; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Muscle, Smooth; Pilot Projects; Urinary Bladder; Urinary Bladder, Neurogenic; Valproic Acid | 2010 |
MMP28 gene expression is regulated by Sp1 transcription factor acetylation.
Topics: Acetylation; Borates; Electrophoretic Mobility Shift Assay; Gene Expression; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoprecipitation; Matrix Metalloproteinases, Secreted; Neoplasm Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Small Interfering; Sp1 Transcription Factor; Sp3 Transcription Factor; Valproic Acid | 2010 |
Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes.
Topics: Astrocytes; Blotting, Western; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Gene Expression; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunity, Innate; Inflammation; Microglia; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2010 |
Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes.
Topics: Acetylation; Butyrates; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation; Genes; HeLa Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; p300-CBP Transcription Factors; Protein Structure, Tertiary; Valproic Acid | 2010 |
Epigenetic modification of vomeronasal (V2r) precursor neurons by histone deacetylation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Epigenesis, Genetic; Female; Gene Expression Profiling; Genetic Markers; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Mice; Microtubule-Associated Proteins; Neural Stem Cells; Neurons; Oligonucleotide Array Sequence Analysis; Receptors, Pheromone; Transcription, Genetic; Valproic Acid; Vomeronasal Organ | 2010 |
Comparison between the effects of valproic acid and trichostatin A on the in vitro development, blastocyst quality, and full-term development of mouse somatic cell nuclear transfer embryos.
Topics: Acetylation; Animals; Anticonvulsants; Blastocyst; Cell Nucleus; Cloning, Organism; Cytoplasm; Embryo Transfer; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nuclear Transfer Techniques; Oocytes; Parthenogenesis; Valproic Acid | 2010 |
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cells, Cultured; Chromatin; Erythroblasts; Erythropoiesis; Female; Fetus; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Liver; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Pregnancy; RNA Interference; Valproic Acid | 2010 |
Histone modifications regulate the norepinephrine transporter gene.
Topics: Animals; Chromatin Immunoprecipitation; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Mice; Norepinephrine Plasma Membrane Transport Proteins; Promoter Regions, Genetic; Protein Binding; Valproic Acid | 2010 |
Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors.
Topics: Adenocarcinoma, Follicular; Adenocarcinoma, Papillary; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Thyroid Neoplasms; Valproic Acid | 2011 |
Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats.
Topics: Angiopoietin-1; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography, Doppler; Heart Ventricles; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ligation; Male; Nitric Oxide Synthase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Valproic Acid; Vascular Endothelial Growth Factor A; Vascular Surgical Procedures; Ventricular Dysfunction, Right; Ventricular Remodeling | 2011 |
Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells.
Topics: Animals; Animals, Newborn; Cell Death; Densitometry; Epigenesis, Genetic; Erythropoietin; Histone Deacetylase Inhibitors; Hydroxamic Acids; Isobutyrates; Microscopy, Phase-Contrast; Rats; Retina; Retinal Ganglion Cells; Valproic Acid | 2011 |
The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells.
Topics: Acetylation; Animals; Binding Sites; Cell Differentiation; Cell Line; Chromatin Assembly and Disassembly; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Embryonic Stem Cells; Enhancer Elements, Genetic; Fibroblast Growth Factor 4; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histones; Homeodomain Proteins; Hydroxamic Acids; Mice; Nanog Homeobox Protein; Pluripotent Stem Cells; RNA Interference; SOXB1 Transcription Factors; Time Factors; Transfection; Valproic Acid | 2011 |
Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells.
Topics: Acetylation; Animals; Antigens, CD34; Cell Differentiation; Cells, Cultured; Chromatin; Cord Blood Stem Cell Transplantation; Erythroid Cells; Fetal Blood; Gene Expression; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Phenotype; Promoter Regions, Genetic; Valproic Acid | 2011 |
Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos.
Topics: Acetylation; Animals; Embryonic Development; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Microscopy, Fluorescence; Nuclear Transfer Techniques; Reproductive Techniques, Assisted; Swine; Valproic Acid | 2011 |
Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells.
Topics: Abnormalities, Drug-Induced; Animals; Butyrates; Cell Line; Embryonic Development; Embryonic Stem Cells; Fatty Acids, Unsaturated; Gene Expression Regulation, Developmental; Genetic Association Studies; Genetic Markers; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Microarray Analysis; Neural Tube Defects; RNA, Messenger; Teratogens; Toxicogenetics; Valproic Acid | 2011 |
Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.
Topics: Acetylation; Animals; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; COS Cells; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Male; Models, Biological; p21-Activated Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; Tumor Suppressor Protein p53; Valproic Acid | 2011 |
Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors.
Topics: CD4-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Histone Deacetylase Inhibitors; HIV Infections; Humans; Hydroxamic Acids; Valproic Acid; Virus Latency | 2011 |
Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.
Topics: Aldehyde Dehydrogenase 1 Family; Amino Acids; Animals; Animals, Newborn; Calbindin 2; Calbindins; Cell Movement; Cerebral Cortex; Dopamine Antagonists; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Food, Formulated; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Hydroxamic Acids; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Organ Culture Techniques; Parvalbumins; Pregnancy; Retinal Dehydrogenase; Retinol-Binding Proteins; S100 Calcium Binding Protein G; Salicylamides; Signal Transduction; Telencephalon; Tretinoin; Valproic Acid; Vitamin A | 2011 |
HDAC activity is required during Xenopus tail regeneration.
Topics: Acetylation; Animals; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Regeneration; Tail; Valproic Acid; Xenopus laevis; Xenopus Proteins | 2011 |
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy, Adjuvant; Computer Simulation; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Models, Biological; Neoplasm Micrometastasis; Panobinostat; Tumor Burden; Tumor Suppressor Proteins; Ubiquitin Thiolesterase; Uveal Neoplasms; Valproic Acid; Vorinostat; Xenograft Model Antitumor Assays | 2012 |
Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; DNA Damage; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ellipticines; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microsomes, Liver; Models, Biological; Neuroblastoma; Rats; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid | 2011 |
Valproic acid phase shifts the rhythmic expression of Period2::Luciferase.
Topics: Animals; Anticonvulsants; Cells, Cultured; Circadian Rhythm; Female; Fibroblasts; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lithium; Luciferases; Luminescent Measurements; Mice; Mice, Transgenic; Period Circadian Proteins; Recombinant Fusion Proteins; Suprachiasmatic Nucleus; Valproic Acid | 2011 |
Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Calcification, Physiologic; Caspase 3; Cell Count; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dental Pulp; Dentinogenesis; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Regeneration; Tumor Suppressor Protein p53; Valproic Acid | 2012 |
[Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer].
Topics: Animals; Culture Media; Dose-Response Relationship, Drug; Embryonic Development; Female; Hydroxamic Acids; Macaca fascicularis; Male; Nuclear Transfer Techniques; Swine; Time Factors; Valproic Acid | 2012 |
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors.
Topics: Acetylation; Blotting, Western; Cell Cycle; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Valproic Acid; Vorinostat | 2012 |
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Epigenesis, Genetic; Eye Proteins; Histone Deacetylase Inhibitors; Histones; Homeodomain Proteins; Humans; Hydroxamic Acids; Methylation; Nanog Homeobox Protein; Neural Plate; Neural Stem Cells; Neuroepithelial Cells; Octamer Transcription Factor-3; Oligonucleotide Array Sequence Analysis; Paired Box Transcription Factors; PAX6 Transcription Factor; Principal Component Analysis; Promoter Regions, Genetic; Protein Processing, Post-Translational; Repressor Proteins; Transcription, Genetic; Transcriptome; Valproic Acid | 2012 |
Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Caspase 7; Drug Synergism; Etoposide; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; U937 Cells; Valproic Acid | 2012 |
Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity.
Topics: Animals; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Histone Deacetylases; Hydroxamic Acids; Mice; Otx Transcription Factors; Promoter Regions, Genetic; Transcription, Genetic; Valproic Acid | 2012 |
Targeting the MAGE A3 antigen in pancreatic cancer.
Topics: Adenocarcinoma; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokines; Decitabine; Deoxycytidine; DNA Methylation; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Male; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Receptors, Antigen, T-Cell; T-Lymphocytes; Testis; Valproic Acid | 2012 |
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins.
Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Subcutaneous; Lysine; Male; Models, Animal; Muscle Contraction; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroglycerin; p300-CBP Transcription Factors; Pyridines; Rats; Valproic Acid; Vasodilation | 2012 |
Valproate activates ERK signaling pathway in primary human hepatocytes.
Topics: Cells, Cultured; Hepatocytes; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MAP Kinase Signaling System; Phosphorylation; Valproic Acid | 2014 |
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Embryonal; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Luciferases; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Receptor Subfamily 6, Group A, Member 1; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Time Factors; Tissue Array Analysis; Transcription, Genetic; Transfection; Tretinoin; Valproic Acid | 2013 |
Regulation of primitive hematopoiesis by class I histone deacetylases.
Topics: Animals; DNA Primers; Erythroid Precursor Cells; Gastrula; Hematopoiesis; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Immunoblotting; In Situ Hybridization; Mice; Real-Time Polymerase Chain Reaction; Valproic Acid; Xenopus laevis; Yolk Sac | 2013 |
Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo.
Topics: Acetylation; Animals; Biphenyl Compounds; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Lignans; Liver Neoplasms; Mice; Mice, Nude; Proteasome Endopeptidase Complex; Proteolysis; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors.
Topics: Animals; Annexin A1; Apoptosis; Butyrates; Cell Line, Tumor; Cytokines; Databases, Chemical; HEK293 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; HL-60 Cells; Humans; Hydroxamic Acids; Macrophages; Male; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neutrophils; Phagocytosis; Transcriptome; Valproic Acid | 2013 |
Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a.
Topics: CA-19-9 Antigen; Cell Line; Glycoproteins; Glycosyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Male; Mucin-1; Oligosaccharides; Prostate; Prostatic Neoplasms; Tumor Cells, Cultured; Valproic Acid; Vorinostat | 2013 |
Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Survival; DNA Primers; Embryonic Development; Endoplasmic Reticulum Stress; Fluorescence; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Situ Nick-End Labeling; Nuclear Transfer Techniques; Real-Time Polymerase Chain Reaction; Valproic Acid | 2014 |
Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells.
Topics: Animals; Bone Morphogenetic Protein 2; Calcification, Physiologic; Caspase 3; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Dental Pulp; Dentinogenesis; Dose-Response Relationship, Drug; Epigenesis, Genetic; Flow Cytometry; Histone Deacetylase Inhibitors; Hydroxamic Acids; Intermediate Filament Proteins; Male; Nerve Tissue Proteins; Nestin; Osteopontin; Primary Cell Culture; Rats; Rats, Wistar; Time Factors; Transcriptome; Valproic Acid | 2013 |
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Topics: Antigen-Presenting Cells; Antigens, Neoplasm; Azacitidine; B-Lymphocytes; Cancer Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Melanoma; Neoplasms; RNA, Messenger; Telomerase; Telomere; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat | 2013 |
Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis.
Topics: Acetylation; Animals; Doxorubicin; Female; Fibrosis; Glomerulosclerosis, Focal Segmental; Histone Deacetylase Inhibitors; Hydroxamic Acids; Immunohistochemistry; Inflammation; Kidney; Kidney Diseases; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Neutrophil Infiltration; RNA, Messenger; Valproic Acid | 2013 |
A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons.
Topics: Acetylation; Animals; Anticonvulsants; Apoptosis; Butyric Acid; Cell Line; Cells, Cultured; Embryonic Stem Cells; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Mice; Neural Stem Cells; Neurons; Protein Processing, Post-Translational; Valproic Acid | 2013 |
Valproic acid promotes human hair growth in in vitro culture model.
Topics: Alkaline Phosphatase; Animals; Axin Protein; beta Catenin; Cell Survival; Female; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hair; Hair Follicle; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Signal Transduction; Tissue Culture Techniques; Valproic Acid | 2013 |
Class I lysine deacetylases facilitate glucocorticoid-induced transcription.
Topics: Acetylation; Amidohydrolases; Animals; Cell Line, Tumor; Dexamethasone; Enzyme Inhibitors; Glucocorticoids; Histones; HSP90 Heat-Shock Proteins; Hydroxamic Acids; Lysine; Mice; Peptides, Cyclic; Protein Binding; Receptors, Glucocorticoid; Transcription, Genetic; Transcriptional Activation; Valproic Acid | 2013 |
Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors.
Topics: Acetylation; Angiotensin II; Carbazoles; Dextrans; Drug Carriers; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lactic Acid; Liposomes; Nanoparticles; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sirtuin 1; Valproic Acid | 2014 |
HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model.
Topics: Acetylation; Analgesics; Animals; Chromatin Assembly and Disassembly; Disease Models, Animal; Epigenesis, Genetic; Ganglia, Spinal; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Hypesthesia; Ligation; Male; Mice; Mice, Inbred C57BL; NAV1.8 Voltage-Gated Sodium Channel; Nerve Fibers, Unmyelinated; Pain Measurement; Pain Threshold; Sciatic Nerve; Sciatic Neuropathy; Time Factors; Valproic Acid; Vorinostat | 2013 |
Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice.
Topics: Animals; Animals, Newborn; Embryo, Mammalian; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Interpersonal Relations; Mice; Mice, Inbred C57BL; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rotarod Performance Test; Smell; Social Behavior Disorders; Valproic Acid; Vocalization, Animal | 2013 |
Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus.
Topics: Acetylglucosamine; Aspergillus; Azacitidine; Butyrates; Chromatin; Cytochalasins; Histone Deacetylase Inhibitors; Hydroxamic Acids; Methyltransferases; Patulin; Peptones; Pyrrolidinones; Valproic Acid | 2013 |
Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2.
Topics: Acetylation; Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Calbindins; Cell Differentiation; Cells, Cultured; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Extracellular Signal-Regulated MAP Kinases; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Mice; Neoplasm Proteins; Neurons; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, trkB; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins; Valproic Acid | 2013 |
Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.
Topics: Animals; Antigens, CD34; Azacitidine; Cell Proliferation; Cells, Cultured; Decitabine; DNA Methylation; Epigenesis, Genetic; Fetal Blood; Gene Expression; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Thy-1 Antigens; Transplantation, Heterologous; Valproic Acid | 2014 |
Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact.
Topics: Action Potentials; Animals; Apoptosis; Astacoidea; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Indoles; Lasers; Mechanoreceptors; Necrosis; Neuroglia; Organometallic Compounds; Photic Stimulation; Photosensitizing Agents; Valproic Acid | 2014 |
The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells.
Topics: Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplastic Stem Cells; Neural Stem Cells; Neurogenesis; Valproic Acid | 2015 |
The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells.
Topics: Acetylation; Adenosine; Animals; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Epigenesis, Genetic; Glioma; Histones; Hydroxamic Acids; Piperazines; Quinazolines; Rats; Valproic Acid | 2014 |
Changes in chromatin structure in NIH 3T3 cells induced by valproic acid and trichostatin A.
Topics: Animals; Cell Proliferation; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; NIH 3T3 Cells; Valproic Acid | 2014 |
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.
Topics: Acetylation; Cell Differentiation; Embryonic Stem Cells; Epigenesis, Genetic; Eye Proteins; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histones; Homeodomain Proteins; Humans; Hydroxamic Acids; Methylation; Paired Box Transcription Factors; PAX6 Transcription Factor; Repressor Proteins; Time Factors; Transcriptome; Valproic Acid | 2014 |
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Topics: Acetylation; Animals; Blotting, Western; Caspase 3; Cell Survival; Electroretinography; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Lysine; Male; Neuroprotective Agents; Rats, Inbred BN; Reperfusion Injury; Retinal Degeneration; Retinal Neurons; Valproic Acid | 2014 |
[Functional analysis of Oct4 promoter in Xuhuai goat].
Topics: Animals; Cell Line; Gene Expression Regulation; Genes, Reporter; Goats; Hydroxamic Acids; Octamer Transcription Factors; Promoter Regions, Genetic; Transcription, Genetic; Valproic Acid | 2014 |
SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.
Topics: Antigens, CD34; Basic Helix-Loop-Helix Transcription Factors; Blood Platelets; Cell Differentiation; Cell Lineage; Cells, Cultured; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Megakaryocytes; Plasmids; Protein Interaction Mapping; Proto-Oncogene Proteins; T-Cell Acute Lymphocytic Leukemia Protein 1; Thrombopoiesis; Transcription, Genetic; Valproic Acid; Vorinostat | 2015 |
Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells.
Topics: Cell Line, Tumor; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Osteosarcoma; Real-Time Polymerase Chain Reaction; Receptors, Tumor Necrosis Factor, Member 6b; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor Ligand Superfamily Member 15; Valproic Acid | 2015 |
HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.
Topics: Acetylation; Animals; Cell Proliferation; Ependymoglial Cells; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histones; Hydroxamic Acids; Microscopy, Confocal; Morpholinos; Superior Colliculi; Valproic Acid; Xenopus laevis | 2015 |
HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells.
Topics: Cadherins; Carcinoma; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; HCT116 Cells; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Hydroxamic Acids; Microscopy, Confocal; Neoplasm Invasiveness; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid; Vimentin | 2015 |
Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells.
Topics: Anacardic Acids; Anilides; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Deoxyadenosines; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; L-Lactate Dehydrogenase; Lysine; Neuroblastoma; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thionucleosides; Valproic Acid | 2016 |
Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities.
Topics: Adolescent; Adult; Azacitidine; Cell Culture Techniques; Cell Differentiation; Chromosome Aberrations; Culture Media; Female; Fibroblasts; Humans; Hydroxamic Acids; Induced Pluripotent Stem Cells; Male; Middle Aged; Neural Stem Cells; Schizophrenia; Valproic Acid; Young Adult | 2015 |
Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury.
Topics: Acetylation; Analgesia; Analgesics; Animals; Down-Regulation; Drug Resistance; Ganglia, Spinal; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Male; Mice, Inbred C57BL; Morphine; Neuralgia; Peripheral Nerve Injuries; Receptors, Opioid, mu; Valproic Acid | 2015 |
HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Animals; Calcium-Binding Proteins; Cell Line; DNA-Binding Proteins; Enzyme Activation; Gastric Mucosa; Ghrelin; Histone Deacetylases; Hydroxamic Acids; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiprotein Complexes; Nerve Tissue Proteins; Nucleobindins; Obesity; Phosphorylation; Regulatory-Associated Protein of mTOR; RNA Interference; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Valproic Acid | 2015 |
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro.
Topics: Cell Proliferation; Cells, Cultured; Extracellular Matrix; Glomerulonephritis, IGA; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoglobulin A; Kidney; Mesangial Cells; Protein Aggregation, Pathological; Valproic Acid | 2016 |
In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis.
Topics: Animals; Animals, Genetically Modified; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lipid Metabolism; Organogenesis; Valproic Acid; Zebrafish | 2016 |
Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment.
Topics: A549 Cells; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Calcium; Cell Death; Cell Survival; Culture Media; DNA Damage; DNA Repair; Down-Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasms; Plasma Gases; Poly (ADP-Ribose) Polymerase-1; Rad51 Recombinase; Valproic Acid | 2016 |
Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism.
Topics: Antigens, CD; Butyric Acid; Cadherins; Endothelium; Gene Expression; Gene Knockdown Techniques; Half-Life; Histone Deacetylase 1; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Human Umbilical Vein Endothelial Cells; Humans; Hydroxamic Acids; Neovascularization, Physiologic; Repressor Proteins; RNA, Messenger; RNA, Small Interfering; Valproic Acid; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo.
Topics: Cell Culture Techniques; Cells, Cultured; Fetal Blood; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia; Valproic Acid | 2017 |
Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity.
Topics: Antineoplastic Agents; Apoptosis; Butyrates; Cadherins; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Neoplasm Invasiveness; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Valproic Acid; Vorinostat | 2016 |
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.
Topics: Cell Line, Tumor; Chromosomal Instability; Gene Expression Regulation, Neoplastic; Histone Deacetylase 2; Histone Deacetylases; Humans; Hydroxamic Acids; Mutation; Phosphoric Diester Hydrolases; Rhabdomyosarcoma; RNA, Small Interfering; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; TATA-Binding Protein Associated Factors; Valproic Acid | 2016 |
Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.
Topics: Animals; Calcineurin; Calcium; Calcium-Binding Proteins; Cluster Analysis; Epigenesis, Genetic; Gene Expression Profiling; Green Fluorescent Proteins; Hippocampus; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Neurites; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Plasmids; Real-Time Polymerase Chain Reaction; Software; Up-Regulation; Valproic Acid; Vorinostat | 2017 |
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.
Topics: Apoptosis; Autophagy; Bortezomib; Cell Line, Tumor; Cell Survival; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mutant Proteins; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Valproic Acid | 2017 |
Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells.
Topics: Adolescent; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Dental Pulp; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Regeneration; Stem Cells; Valproic Acid; Young Adult | 2018 |
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Topics: Acetylation; Animals; Butyrates; Cell Line; Cell Survival; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Dose-Response Relationship, Drug; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Homeodomain Proteins; Hydroxamic Acids; Nuclear Receptor Subfamily 4, Group A, Member 2; Promoter Regions, Genetic; Rats; RNA, Messenger; Transcription Factors; Valproic Acid | 2017 |
Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Bone Morphogenetic Protein 7; Cell Line; Cisplatin; Epithelial Cells; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Kidney Tubules; Mice; Mice, Inbred C57BL; Valproic Acid | 2017 |
Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.
Topics: Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hydroxamic Acids; Intestinal Polyposis; Intestine, Small; Loss of Heterozygosity; Mice, Transgenic; Mutation; Pyridines; Pyrimidines; Tissue Culture Techniques; Valproic Acid; Wnt Signaling Pathway | 2018 |
High dose of histone deacetylase inhibitors affects insulin secretory mechanism of pancreatic beta cell line.
Topics: Animals; Butyric Acid; Cattle; Cell Line; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Insulin; Insulin-Secreting Cells; Valproic Acid | 2018 |
Epigenetic Drugs in the Treatment of Endometriosis.
Topics: Endometriosis; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Stromal Cells; Treatment Outcome; Valproic Acid | 2019 |
Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Female; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Mice; Mice, Transgenic; Rats, Sprague-Dawley; Signal Transduction; Stem Cells; Tendon Injuries; Tendons; Valproic Acid | 2018 |
HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells.
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Deoxycytidine; Epithelial-Mesenchymal Transition; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Valproic Acid; Vimentin | 2018 |
CCR7 preservation via histone deacetylase inhibition promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells.
Topics: Antigens, CD; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Neoplasm Staging; Nuclear Proteins; Promoter Regions, Genetic; Receptors, CCR7; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Survival Analysis; Twist-Related Protein 1; Valproic Acid; Vimentin | 2018 |
Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; DNA Damage; Drug Therapy, Combination; Etoposide; Gamma Rays; Histone Deacetylase Inhibitors; Histones; Homeostasis; Humans; Hydroxamic Acids; Methyl Methanesulfonate; Mice; Valproic Acid; Vorinostat | 2019 |
Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure.
Topics: 3-Hydroxybutyric Acid; Antioxidants; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Cell Survival; Epithelial Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lens, Crystalline; Ultraviolet Rays; Valproic Acid; Vorinostat | 2019 |
Inhibition of Histone H3K27 Acetylation Orchestrates Interleukin-9-Mediated and Plays an Anti-Inflammatory Role in Cisplatin-Induced Acute Kidney Injury.
Topics: Acetylation; Acute Kidney Injury; Animals; Cell Line; Cisplatin; Culture Media, Conditioned; Cytokines; Gene Expression; Histone Code; Histone Deacetylase 2; Histones; Humans; Hydroxamic Acids; Interleukin-9; Kidney Tubules, Proximal; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Random Allocation; Recombinant Proteins; Specific Pathogen-Free Organisms; Valproic Acid | 2020 |
5-Azacytidine upregulates melatonin MT
Topics: Animals; Azacitidine; Cell Line; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melatonin; Rats; Receptor, Melatonin, MT1; Receptors, Melatonin; RNA, Messenger; Transcriptional Activation; Valproic Acid | 2020 |
Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hydroxamic Acids; Isothiocyanates; Mice; Mice, Inbred BALB C; Ovalbumin; Relaxin; Resveratrol; Spectroscopy, Fourier Transform Infrared; Sulfoxides; Synchrotrons; Treatment Outcome; Valproic Acid | 2020 |
A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases.
Topics: Animals; Animals, Genetically Modified; Antibiotics, Antineoplastic; Anticonvulsants; Antifungal Agents; Butyrates; Collagen Type II; Craniofacial Abnormalities; Gene Expression Regulation, Developmental; Genes, Reporter; Histone Deacetylases; Hydroxamic Acids; Luminescent Proteins; Peptides; Red Fluorescent Protein; Valproic Acid; Zebrafish | 2021 |