valproic acid has been researched along with tretinoin in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.12) | 18.7374 |
| 1990's | 9 (9.28) | 18.2507 |
| 2000's | 33 (34.02) | 29.6817 |
| 2010's | 41 (42.27) | 24.3611 |
| 2020's | 10 (10.31) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ehlers, K; Merker, HJ; Nau, H; Stürje, H | 1 |
| Dawson, DA | 1 |
| Harris, C; Juchau, MR; Luchtel, DL; Seegmiller, RE | 1 |
| Gossrau, R; Graf, R; Günther, T; Merker, HJ; Vormann, J | 1 |
| Holtzman, NA; Khoury, MJ | 1 |
| Brunborg, G; Støttum, A; Wiger, R | 1 |
| Fischkoff, SA; Walter, E | 1 |
| Andersson, A; Berggren-Söderlund, M; Fex, G; Larsson, K | 1 |
| Althoen, MC; Cotman, CW; Loo, DT | 1 |
| Cascino, D; Fasulo, G; Giudice, G; Romancino, D; Sconzo, G | 1 |
| Johnson, EM | 1 |
| Bosschaert, J; Clotman, F; Gofflot, F; Picard, JJ; Van Maele-Fabry, G | 1 |
| Berezin, V; Bock, E; Skladchikova, G | 1 |
| Chen, Y; Costa, E; Costa, RH; Grayson, DR; Sharma, RP | 1 |
| Bobseine, KL; Cardon, M; Chernoff, N; Hartig, P; Kawanishi, CY; Massenburg, G; Schmid, J | 1 |
| Aivado, M; Bernhardt, A; Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Kuendgen, A; Strupp, C | 1 |
| Padmanabhan, RR; Rengasamy, P | 1 |
| Altar, CA; Drabik, CE; Laeng, P; Lemire, AL; Mallon, BS; Pitts, RL; Tang, H; Thyagarajan, R; Weiner, A | 1 |
| Carney, EW; DeSesso, JM; Scialli, AR; Watson, RE | 1 |
| Gudas, LJ; Mongan, NP | 1 |
| Beissert, T; Boehrer, S; Bug, G; Gül, H; Hoelzer, D; Kampfmann, M; Ottmann, OG; Pfeifer, H; Ruthardt, M; Schwarz, K; Zheng, X | 1 |
| Cappia, S; Cilloni, D; Familiari, U; Giugliano, E; Guerrasio, A; Lo Coco, F; Messa, E; Morotti, A; Pautasso, M; Pelicci, PG; Pilatrino, C; Saglio, G | 1 |
| Bordeleau, L; Jurisica, I; Minden, MD; Suarez Saiz, F; Trus, MR; Yang, L | 1 |
| Chaibi, P; Degos, L; Dombret, H; Raffoux, E | 1 |
| Fox, F; Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Kuendgen, A; Steidl, C; Strupp, C | 1 |
| Bug, G; Heinzel, T; Hoelzer, D; Kampfmann, M; Kramer, OH; Neubauer, A; Ottmann, OG; Ritter, M; Romanski, A; Ruthardt, M; Schoch, C; Schwarz, K; Wassmann, B | 1 |
| Barth, PJ; Burchert, A; Cai, D; Neubauer, A; Ottmann, OG; Wang, Y | 1 |
| Dohner, H; Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Kuendgen, A; Schlenk, R; Schmid, M; Steidl, C | 1 |
| Anensen, N; Bruserud, Ø; Børresen-Dale, AL; Gjertsen, BT; Ryningen, A; Skavland, J; Stapnes, C | 1 |
| Bruserud, Ø; Gjertsen, BT; Ryningen, A; Stapnes, C | 1 |
| Qi, H; Ratnam, M | 1 |
| Amadori, S; Careddu, A; Cimino, G; Fazi, F; Fenu, S; Finolezzi, E; Fiorini, R; Lo-Coco, F; Mancini, M; Mandelli, F; Nanni, M; Nervi, C; Padula, F; Pelicci, PG; Petti, MC; Spiriti, MA; Travaglini, L; Venditti, A | 1 |
| Guo, SW; Wu, Y | 1 |
| Cortes, J; Estey, EH; Estrov, Z; Faderl, S; Garcia-Manero, G; Giles, F; Issa, JP; Kantarjian, HM; Ouzounian, S; Pierce, S; Quezada, A; Ravandi, F; Soriano, AO; Wierda, WG; Yang, H | 1 |
| Gattermann, N; Kuendgen, A | 1 |
| Clothier, RH; Hurst, HS; Pratten, M | 1 |
| Ai, GW; Liu, W; Ma, XX; Meng, XQ; Meng, YS; Wei, R; Zhang, YX | 1 |
| Coleman, MD; Hill, EJ; Prince, M; Woehrling, EK | 1 |
| Bruserud, O; Corbascio, M; Gjertsen, BT; Lassalle, P; Ryningen, A; Stapnes, C | 1 |
| Bellos, F; Mahlknecht, U | 1 |
| Catellani, S; Garuti, A; Gobbi, M; Pierri, I; Poggi, A; Zocchi, MR | 1 |
| Bonamassa, B; Canistro, D; Contestabile, A; Crochemore, C; Paolini, M; Pena-Altamira, E; Virgili, M | 1 |
| Moriwaki, H; Sakai, H; Shimizu, M; Shirakami, Y; Tatebe, H; Tsurumi, H; Yasuda, Y | 1 |
| David, KA; Gudas, LJ; Mongan, NP; Nanus, DM; Smith, C | 1 |
| Dolezel, P; Ulrichova, J; Vrba, J | 1 |
| Deuschle, M; Hohmann, S; Lederbogen, F; Schloss, P; Schweinfurth, N | 1 |
| Calin, GA; Fang, Z; Garcia-Manero, G; Hu, Y; Kantarjian, HM; Wei, Y; Yang, H | 1 |
| Boëlle, PY; Chevret, S; Chomienne, C; Cras, A; Daniel, MT; de Labarthe, A; Degos, L; Dombret, H; Fenaux, P; Gardin, C; Maarek, O; Malfuson, JV; Marolleau, JP; Maury, S; Raffoux, E; Recher, C; Reman, O; Rousselot, P; Turlure, P; Victor, M | 1 |
| El-Akabawy, G; Jeffries, A; Medina, LM; Modo, M; Price, J | 1 |
| Cheong, SC; Gan, CP; Hamid, S; Hor, SY; Ismail, SM; Saunders, N; Teo, SH; Wan Mustafa, WM; Zain, RB | 1 |
| Bhide, PG; Crandall, JE; Dräger, UC; Duester, G; Goodman, T; McCaffery, P; McCarthy, DM | 1 |
| Banaschewski, T; Deuschle, M; Hohmann, S; Lau, T; Lederbogen, F; Schloss, P; Schweinfurth, N | 1 |
| Cao, Z; Feng, D; Li, C; Ling, B; Liu, R; Ma, J; Wei, H; Zhang, L; Zhao, W; Zhou, H; Zhou, Y | 1 |
| Dal Zuffo, R; de Thé, H; Leiva, M; Mercurio, C; Minucci, S; Moretti, S; Pallavicini, I; Peres, L; Soilihi, H | 1 |
| Bruserud, O; Fredly, H; Gjertsen, BT; Reikvam, H | 1 |
| Ferreri, AM; Guerra, F; Orlandi, M; Papi, A | 1 |
| Baraty, C; Bianco, C; Castro, NP; Gonzales, M; Held, N; Karasawa, H; Rangel, MC; Rollman, K; Salomon, DS; Strizzi, L | 1 |
| Bruserud, Ø; Gjertsen, BT; McCormack, E; Mujić, M; Osdal, T | 1 |
| Glasow, A; Kortmann, RD; Patties, I | 1 |
| Chen, J | 1 |
| Feng, D; Hu, W; Ling, B; Ma, C; Tian, Y; Wei, H; Wu, J; Zhao, W; Zhou, H; Zhou, Y | 1 |
| Aizawa, S; Hatta, Y; Horikoshi, A; Iriyama, N; Takagi, N; Takei, M; Takeuchi, J; Toyoda, H; Yoshino, Y; Yuan, B | 1 |
| Brossart, P; Brugger, W; Derigs, HG; Döhner, H; Döhner, K; Gaidzik, VI; Göttlicher, M; Götze, K; Greil, R; Heil, G; Held, G; Horst, HA; Kirchen, H; Köhne, CH; Koller, E; Kremers, S; Matzdorff, A; Nachbaur, D; Paschka, P; Raghavachar, A; Ringhoffer, M; Schlenk, RF; Tassara, M; Wattad, M; Wulf, G | 1 |
| Del Río, E; Estevan, C; Fuster, E; Pamies, D; Sogorb, MA; Vilanova, E | 1 |
| Chu, T; Feng, S; Kong, X; Li, F; Liu, B; Lu, L; Wang, T; Zhou, H | 1 |
| Brenner, AK; Bruserud, Ø; Ersvaer, E; Reikvam, H; Vetås, K | 1 |
| Cieslik, C; Döhner, K; Grishina, O; Hackanson, B; Lübbert, M; Lubrich, B; May, AM; Müller, MJ; Schmoor, C | 1 |
| Bailey, JM; Brooks, RA; De La Rocha, AJ; Janardhan, S; Karbhari, N; Levin, ED; Oliveri, AN | 1 |
| Kemler, R; Kugler, J; Luch, A; Oelgeschläger, M | 1 |
| Glasow, A; Kortmann, RD; Menzel, F; Patties, I | 1 |
| Li, AS; Marikawa, Y | 1 |
| Ding, H; Guo, Q; Han, Y; Jiang, G; Li, L; Li, X; Liao, Q; Ma, R; Ren, X; Song, G; Tian, J; Zhang, X; Zou, H | 1 |
| Balleari, E; Bernal, T; Beyne-Rauzy, O; Bordessoule, D; Calabuig, M; Cametti, G; Campelo, MD; Cheze, S; Cony-Makhoul, P; Dreyfus, F; Fenaux, P; Fensterl, J; Ferrero, D; Gaidano, G; Germing, U; Gioia, D; Götze, K; Guerci-Bresler, A; Hamel, JF; Kaivers, J; Kelaidi, C; Komrokji, R; Kotsianidis, I; Müller-Thomas, C; Pane, F; Park, S; Ramos, F; Roboz, GJ; Rose, C; Sanna, A; Santini, V; Sanz, GF; Sapena, R; Sekeres, MA; Stamatoullas, A; Steensma, DP; Thépot, S; Toma, A; Vey, N; Wattel, E | 1 |
| Goh, TW; Hin-Fai Yam, G; Mehta, JS; Setiawan, M; Tan, XW | 1 |
| Bruserud, Ø; Erdal, S; Forthun, RB; Fredly, H; Gjertsen, BT; Hovland, R; Reikvam, H | 1 |
| Ba, Y; Cheng, X; Hu, Y; Huang, H; Li, W; Li, X; Su, Y; Wang, Y; Wu, Z; Zhang, H | 1 |
| Mennen, RHG; Pennings, JLAJ; Piersma, AHA | 1 |
| Bruserud, Ø; Fredly, HK; Gjertsen, BT; Grønningsæter, IS; Hatfield, KJ | 1 |
| Becker, H; Brugger, W; Bug, G; Crysandt, M; De Wit, M; Döhner, H; Döhner, K; Duyster, J; Ganser, A; Germing, U; Giagounidis, A; Götze, KS; Grishina, O; Hackanson, B; Heil, G; Heuser, M; Jost, E; Krauter, J; Kuendgen, A; Lindemann, HW; Lübbert, M; May, AM; Müller-Tidow, C; Neubauer, A; Salih, HR; Schittenhelm, MM; Schlenk, RF; Schmoor, C; Scholl, S; Schwaenen, C; Thol, F; Wäsch, R | 1 |
| Jain, V; Kamble, V; Nanda, A; Patel, H; Warawdekar, UM | 1 |
| Bhonde, R; Datar, S; Konala, VBR; Nandakumar, S; Pal, R; Surendran, H | 1 |
| Abdel-Aziz, AK; Ceccacci, E; de Thé, H; Minucci, S; Moretti, S; Pallavicini, I; Santoro, F | 1 |
| Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z | 1 |
| Chen, J; Hu, C; Li, T; Luo, L; Wei, H; Wu, Q; Yang, T; Yuan, B | 1 |
| Choi, J; Hwang, J; Jang, S; Jeong, HS; Ramalingam, M | 1 |
| Mahdiani, S; Mohammadpour, AH; Omidkhoda, N; Rahimi, H; Samadi, S | 1 |
| Chen, J; Hu, C; Li, T; Lin, F; Luo, L; Yang, T; Yuan, B | 1 |
| Bars, R; Dumont, F; Hallmark, N; Pallardy, M; Piersma, AH; Samrani, LMM; Tinwell, H | 1 |
6 review(s) available for valproic acid and tretinoin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison.
Topics: Animals; Biological Transport; Carbamazepine; Embryonic Development; Female; Humans; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Placenta; Pregnancy; Rabbits; Rats; Salicylic Acid; Species Specificity; Teratogens; Toxicity Tests; Tretinoin; Valproic Acid; Yolk Sac | 2004 |
Valproic acid for the treatment of myeloid malignancies.
Topics: Acute Disease; Apoptosis; Cell Line, Tumor; Drug Synergism; Drug Therapy, Combination; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid; Tretinoin; Valproic Acid | 2007 |
Valproic acid and all-trans retinoic acid: meta-analysis of a palliative treatment regimen in AML and MDS patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Enzyme Inhibitors; Humans; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Palliative Care; Prevalence; Retrospective Studies; Treatment Outcome; Tretinoin; Valproic Acid | 2008 |
Efficacy and Safety of Valproic Acid in Myelodysplastic Syndrome and Acute Myeloid Leukemia; a Narrative Review.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Tretinoin; Valproic Acid | 2023 |
13 trial(s) available for valproic acid and tretinoin
| Article | Year |
|---|---|
Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Treatment Outcome; Tretinoin; Valproic Acid | 2004 |
Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid.
Topics: Acute Disease; Aged; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Myelodysplastic Syndromes; Platelet Count; Risk; Tretinoin; Valproic Acid | 2005 |
Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Treatment Outcome; Tretinoin; Valproic Acid | 2005 |
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.
Topics: Administration, Oral; Aged; Aged, 80 and over; Blotting, Western; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Flow Cytometry; Follow-Up Studies; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Prospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Treatment Outcome; Tretinoin; Valproic Acid | 2005 |
The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid; Male; Middle Aged; Treatment Outcome; Tretinoin; Valproic Acid | 2006 |
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome.
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Child; Child, Preschool; DNA Methylation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Gene Expression Regulation; Histones; Humans; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; RNA, Messenger; Tretinoin; Valproic Acid | 2007 |
Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Enzyme Inhibitors; Histone Deacetylases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Salvage Therapy; Survival Rate; Tissue Distribution; Treatment Outcome; Tretinoin; Valproic Acid | 2010 |
Levels of miR-29b do not predict for response in patients with acute myelogenous leukemia treated with the combination of 5-azacytidine, valproic acid, and ATRA.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cohort Studies; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; MicroRNAs; Myelodysplastic Syndromes; Treatment Outcome; Tretinoin; Valproic Acid | 2011 |
Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; DNA Methylation; DNA, Neoplasm; Epigenomics; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Polymerase Chain Reaction; Survival Rate; Treatment Outcome; Tretinoin; Valproic Acid | 2010 |
Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytokines; Female; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Middle Aged; Neoplasm Proteins; Palliative Care; Prognosis; Theophylline; Tretinoin; Tumor Cells, Cultured; Valproic Acid | 2012 |
Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Critical Care; Cytarabine; Disease-Free Survival; Drug Synergism; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Nuclear Proteins; Nucleophosmin; Survival Rate; Tretinoin; Valproic Acid | 2014 |
DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute mye
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Protocols; Decitabine; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Tretinoin; Valproic Acid | 2015 |
Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Decitabine; Disease-Free Survival; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Tretinoin; Valproic Acid | 2020 |
78 other study(ies) available for valproic acid and tretinoin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity.
Topics: Animals; Dose-Response Relationship, Drug; Gestational Age; Mice; Spina Bifida Cystica; Teratogens; Tretinoin; Valproic Acid | 1992 |
Joint action of t-retinoic and valproic acids on Xenopus embryo development.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Embryo, Nonmammalian; Female; Male; Tretinoin; Valproic Acid; Xenopus laevis | 1991 |
Morphological differences elicited by two weak acids, retinoic and valproic, in rat embryos grown in vitro.
Topics: Animals; Brain; Branchial Region; Cell Differentiation; Culture Techniques; DNA; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Microscopy, Electron, Scanning; Neural Tube Defects; Proteins; Rats; Rats, Inbred Strains; Tretinoin; Valproic Acid | 1991 |
Enzymatic and morphological response of the thymus to drugs in normal and zinc-deficient pregnant rats and their fetuses.
Topics: Animals; Cell Membrane; Dexamethasone; Ethanol; Female; Fetus; Histocytochemistry; Microscopy, Electron; Organ Size; Pregnancy; Pregnancy Complications; Rats; Rats, Inbred Strains; Salicylates; Streptozocin; T-Lymphocytes; Thymus Gland; Tretinoin; Valproic Acid; Zinc | 1987 |
On the ability of birth defects monitoring to detect new teratogens.
Topics: Abnormalities, Drug-Induced; Epidemiologic Methods; Humans; Infant, Newborn; Isotretinoin; Risk; Teratogens; Thalidomide; Tretinoin; Valproic Acid | 1987 |
Estimating chemical developmental hazard in a chicken embryo limb bud micromass system.
Topics: Animals; Cartilage; Cells, Cultured; Chick Embryo; Isoniazid; Proteoglycans; Salicylates; Teratogens; Time Factors; Tretinoin; Valproic Acid | 1988 |
Induction of neutrophilic differentiation of human promyelocytic leukemic cells by branched-chain carboxylic acid anticonvulsant drugs.
Topics: Anticonvulsants; Antineoplastic Agents; Cell Differentiation; Cell Division; Cells, Cultured; Cyclohexanecarboxylic Acids; Humans; Leukemia, Myeloid, Acute; Neutrophils; Tretinoin; Valproic Acid | 1984 |
Low serum concentration of all-trans and 13-cis retinoic acids in patients treated with phenytoin, carbamazepine and valproate. Possible relation to teratogenicity.
Topics: Adult; Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Isotretinoin; Male; Middle Aged; Phenytoin; Teratogens; Tretinoin; Valproic Acid | 1995 |
Differentiation of serum-free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity.
Topics: Animals; Astrocytes; Biomarkers; Blood; Blotting, Western; Brain; Bucladesine; Cattle; Cell Differentiation; Charcoal; Culture Media, Serum-Free; Enzyme Induction; Gene Expression Regulation, Developmental; Glutamate-Ammonia Ligase; Hydrocortisone; Intermediate Filament Proteins; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; Nestin; Stem Cells; Transforming Growth Factor beta; Tretinoin; Valproic Acid | 1995 |
Effect of retinoic acid and valproate on sea urchin development.
Topics: Animals; Anticonvulsants; Fertilization; Isomerism; Ovum; Sea Urchins; Tretinoin; Valproic Acid | 1996 |
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratolytic Agents; Methotrexate; Pregnancy; Risk Assessment; Teratogens; Thalidomide; Tretinoin; Valproic Acid | 1997 |
Postimplantation mouse embryos cultured in vitro. Assessment with whole-mount immunostaining and in situ hybridization.
Topics: Animals; Congenital Abnormalities; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Female; Gene Expression; Growth Disorders; Homeodomain Proteins; Immunoenzyme Techniques; In Situ Hybridization; Mercuric Chloride; Mice; Morphogenesis; Pregnancy; Time Factors; Transcription Factors; Tretinoin; Valproic Acid | 1997 |
Valproic acid, but not its non-teratogenic analogue 2-isopropylpentanoic acid, affects proliferation, viability and neuronal differentiation of the human teratocarcinoma cell line NTera-2.
Topics: Anticonvulsants; Cell Aggregation; Cell Differentiation; Cell Division; Cell Survival; Humans; Mitosis; Molecular Weight; Neurites; Neurons; Pentanoic Acids; Teratocarcinoma; Teratogens; Tretinoin; Valproic Acid | 1998 |
On the epigenetic regulation of the human reelin promoter.
Topics: Base Sequence; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Line; Chromatin; Deoxycytosine Nucleotides; DNA Methylation; Extracellular Matrix Proteins; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Luciferases; Molecular Sequence Data; Nerve Tissue Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tretinoin; Tumor Cells, Cultured; Valproic Acid | 2002 |
Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Developmental; Genes, Homeobox; Gestational Age; In Situ Hybridization; Litter Size; Mice; Mice, Inbred Strains; Nitriles; Pregnancy; Spine; Teratogens; Time Factors; Tretinoin; Valproic Acid | 2003 |
Experimental studies on cervical and lumbar ribs in mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Fetus; Mice; Radiography; Ribs; Teratogens; Tretinoin; Valproic Acid | 2004 |
The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells.
Topics: Animals; Astrocytes; bcl-Associated Death Protein; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Cell Count; Cell Differentiation; Cells, Cultured; Cyclin D2; Cyclins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lithium Chloride; Neurons; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Time Factors; Trans-Activators; Tretinoin; Tubulin; Valproic Acid | 2004 |
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Decitabine; DNA Primers; Enzyme Inhibitors; Histone Deacetylases; Histones; Humans; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Time Factors; Tretinoin; Valproic Acid | 2005 |
Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.
Topics: Animals; Antigens, CD34; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hematopoietic Stem Cells; Homeodomain Proteins; Humans; Mice; Mice, Inbred C57BL; Signal Transduction; Transcription Factors; Tretinoin; Up-Regulation; Valproic Acid | 2005 |
The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Leukemia, Myeloid, Acute; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Structure-Activity Relationship; Tretinoin; Valproic Acid | 2005 |
Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Humans; Leukemia, Myeloid, Acute; Pilot Projects; Time Factors; Treatment Outcome; Tretinoin; Valproic Acid | 2005 |
FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Leukemia, Myelomonocytic, Acute; Mutation; Oncogene Protein v-akt; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Tretinoin; Tumor Cells, Cultured; Valproic Acid | 2006 |
Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report.
Topics: Aminophylline; Antineoplastic Combined Chemotherapy Protocols; DNA-Binding Proteins; Drug Therapy, Combination; Female; Genes, Tumor Suppressor; Humans; Leukemia, Myeloid, Acute; Li-Fraumeni Syndrome; Middle Aged; Mutation; Nuclear Proteins; Treatment Outcome; Tretinoin; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Valproic Acid | 2006 |
Treatment with valproic acid, all-trans retinoic acid (ATRA) and theophyllamine for 9 days caused a persistent increase in peripheral blood platelet counts for a patient with acute myelogenous leukemia.
Topics: Aged, 80 and over; Aminophylline; Blood Platelets; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Platelet Count; Tretinoin; Valproic Acid | 2006 |
Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates.
Topics: Acetylation; Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carrier Proteins; CHO Cells; Cricetinae; Drug Synergism; Enzyme Inhibitors; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Promoter Regions, Genetic; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Retinoic Acid; RNA, Messenger; Substrate Specificity; Tetrahydrofolates; Transcription Factor AP-1; Tretinoin; Up-Regulation; Valproic Acid | 2006 |
Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Differentiation; Enzyme Inhibitors; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myeloid, Acute; Treatment Outcome; Tretinoin; Valproic Acid | 2006 |
Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Endometrium; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Stromal Cells; Tretinoin; Valproic Acid | 2008 |
An evaluation of a novel chick cardiomyocyte micromass culture assay with two teratogens/embryotoxins associated with heart defects.
Topics: Animal Testing Alternatives; Animals; Anticonvulsants; Antineoplastic Agents; Cell Culture Techniques; Cell Differentiation; Chick Embryo; Heart Defects, Congenital; Immunohistochemistry; Models, Biological; Myocytes, Cardiac; Oxazines; Proteins; Toxicity Tests; Tretinoin; Valproic Acid; Xanthenes | 2007 |
[Epigenetic regulation of expression of retinoic acid receptor beta gene in leukemia cell].
Topics: Acetylation; Adult; Aged; Azacitidine; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histones; Humans; Leukemia; Middle Aged; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tretinoin; U937 Cells; Valproic Acid | 2007 |
Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing.
Topics: Acrylamides; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Densitometry; Gene Expression; Humans; Hydroxyurea; Image Processing, Computer-Assisted; Immunohistochemistry; Lithium Chloride; Microscopy, Confocal; Models, Neurological; Nervous System Diseases; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Teratogens; Tretinoin; Valproic Acid | 2008 |
A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid.
Topics: Aged; Aged, 80 and over; Blood Cell Count; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Proteins; Proteoglycans; Risk Factors; Survival Analysis; Theophylline; Tretinoin; Valproic Acid | 2009 |
Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.
Topics: Adult; Aged; Blast Crisis; Cytotoxicity, Immunologic; Female; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; Ligands; Lymphocyte Activation; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily K; Transcriptional Activation; Tretinoin; Valproic Acid | 2009 |
Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis.
Topics: Acetylcholinesterase; Amyotrophic Lateral Sclerosis; Animal Feed; Animals; Antineoplastic Agents; Choline O-Acetyltransferase; Disease Models, Animal; Female; GABA Agents; Gene Dosage; Humans; Life Expectancy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Superoxide Dismutase; Superoxide Dismutase-1; Tretinoin; Valproic Acid | 2009 |
Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; Valproic Acid | 2009 |
Neutrophilic differentiation modulates the apoptotic response of HL-60 cells to sodium butyrate and sodium valproate.
Topics: Apoptosis; Butyrates; Caspase 3; Caspase 9; Cell Cycle; Cell Differentiation; Dimethyl Sulfoxide; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Membrane Potential, Mitochondrial; Neutrophils; Tretinoin; Valproic Acid | 2010 |
Valproic acid and all trans retinoic acid differentially induce megakaryopoiesis and platelet-like particle formation from the megakaryoblastic cell line MEG-01.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Cell Differentiation; Cell Line; Histone Deacetylase Inhibitors; Humans; Megakaryocyte Progenitor Cells; Megakaryocytes; Peptide Fragments; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Tetradecanoylphorbol Acetate; Transcription Factors; Tretinoin; Valproic Acid | 2010 |
Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.
Topics: Antigens, Differentiation; Brain; Brain-Derived Neurotrophic Factor; Bucladesine; Calbindin 2; Calbindins; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Dopamine and cAMP-Regulated Phosphoprotein 32; Hedgehog Proteins; Humans; Huntington Disease; Interneurons; Morpholines; Neural Stem Cells; Purines; S100 Calcium Binding Protein G; Signal Transduction; Transcription Factors; Tretinoin; Up-Regulation; Valproic Acid; Zinc Finger Protein GLI1 | 2011 |
Valproic acid: growth inhibition of head and neck cancer by induction of terminal differentiation and senescence.
Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Decitabine; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Humans; Squamous Cell Carcinoma of Head and Neck; Tretinoin; Valproic Acid | 2012 |
Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.
Topics: Aldehyde Dehydrogenase 1 Family; Amino Acids; Animals; Animals, Newborn; Calbindin 2; Calbindins; Cell Movement; Cerebral Cortex; Dopamine Antagonists; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Food, Formulated; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Hydroxamic Acids; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Organ Culture Techniques; Parvalbumins; Pregnancy; Retinal Dehydrogenase; Retinol-Binding Proteins; S100 Calcium Binding Protein G; Salicylamides; Signal Transduction; Telencephalon; Tretinoin; Valproic Acid; Vitamin A | 2011 |
Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts.
Topics: Blood Platelets; Cell Differentiation; Cell Line; Cell Membrane; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Humans; Megakaryocyte Progenitor Cells; Megakaryocytes; Protein Transport; Serotonin Plasma Membrane Transport Proteins; Tretinoin; Tubulin; Valproic Acid | 2011 |
Combination of valproic acid and ATRA restores RARβ2 expression and induces differentiation in cervical cancer through the PI3K/Akt pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Female; HeLa Cells; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Retinoic Acid; Signal Transduction; Tretinoin; Uterine Cervical Neoplasms; Valproic Acid | 2012 |
Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.
Topics: Acetylation; Animals; Anticonvulsants; Antineoplastic Agents; Cell Differentiation; Cell Transformation, Neoplastic; Flow Cytometry; Leukemia, Promyelocytic, Acute; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Recurrence, Local; Oncogene Proteins, Fusion; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Valproic Acid; Xenograft Model Antitumor Assays | 2012 |
Anti-invasive effects and proapoptotic activity induction by the rexinoid IIF and valproic acid in combination on colon cancer cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Colonic Neoplasms; Dose-Response Relationship, Drug; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Retinoid X Receptor gamma; Tretinoin; Valproic Acid | 2012 |
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Embryonal; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Luciferases; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Receptor Subfamily 6, Group A, Member 1; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Time Factors; Tissue Array Analysis; Transcription, Genetic; Transfection; Tretinoin; Valproic Acid | 2013 |
Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.
Topics: Animals; Anthracyclines; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; CD11b Antigen; CD11c Antigen; Cell Line, Tumor; Cytarabine; Fluorescent Dyes; Green Fluorescent Proteins; HL-60 Cells; Humans; Immunophenotyping; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Luminescent Measurements; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Optical Imaging; Tretinoin; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Decitabine; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Epigenesis, Genetic; Humans; Medulloblastoma; Neoplasm Grading; Tretinoin; Tumor Stem Cell Assay; Valproic Acid | 2013 |
Impaired cardiovascular function caused by different stressors elicits a common pathological and transcriptional response in zebrafish embryos.
Topics: Animals; Carbaryl; Cell Proliferation; Disease Models, Animal; Edema, Cardiac; Embryo, Nonmammalian; Gene Expression; Genes, cdc; Heart; Heart Failure; Morpholinos; Myocardial Contraction; Myocardium; Phenotype; Polychlorinated Dibenzodioxins; Tretinoin; Valproic Acid; Zebrafish | 2013 |
Targeting of histone deacetylases to reactivate tumour suppressor genes and its therapeutic potential in a human cervical cancer xenograft model.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Promoter Regions, Genetic; Protein Binding; Retinoid X Receptor beta; Transcriptional Activation; Tretinoin; Tumor Burden; Tumor Suppressor Proteins; Uterine Cervical Neoplasms; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
Enhancement of differentiation induction and upregulation of CCAAT/enhancer-binding proteins and PU.1 in NB4 cells treated with combination of ATRA and valproic acid.
Topics: Antineoplastic Agents; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Division; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Proto-Oncogene Proteins; RNA, Messenger; Steroids; Trans-Activators; Transcriptional Activation; Tretinoin; Valproic Acid | 2014 |
Organophosphorus pesticide chlorpyrifos and its metabolites alter the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells in a comparable way to other model neurodevelopmental toxicants.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Survival; Cells, Cultured; Chlorpyrifos; Embryonic Stem Cells; Gene Expression Regulation; Mice; Neurogenesis; Organophosphorus Compounds; Penicillin G; Pesticides; Tretinoin; Valproic Acid | 2014 |
In vitro characteristics of valproic acid and all-trans-retinoic acid and their combined use in promoting neuronal differentiation while suppressing astrocytic differentiation in neural stem cells.
Topics: Animals; Antineoplastic Agents; Astrocytes; beta Catenin; Cell Differentiation; Cells, Cultured; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Nerve Tissue Proteins; Neural Stem Cells; Neurites; Neurons; Prosencephalon; Rats; Rats, Wistar; Time Factors; Tretinoin; Valproic Acid | 2015 |
Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid.
Topics: ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Cell Membrane; Cell Proliferation; Cell Survival; Cells, Cultured; Cytarabine; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Fas Ligand Protein; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lectins, C-Type; Lymphocyte Activation; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Tretinoin; Valproic Acid | 2015 |
Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish.
Topics: Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Habituation, Psychophysiologic; Larva; Motor Activity; Reflex, Startle; Social Behavior; Tretinoin; Valproic Acid; Zebrafish | 2016 |
Editor's Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line.
Topics: Animals; beta Catenin; Cell Differentiation; Embryonic Stem Cells; Genes, Reporter; Mice; Mice, Transgenic; Myocytes, Cardiac; Real-Time Polymerase Chain Reaction; Teratogens; Tretinoin; Valproic Acid; Wnt Proteins | 2016 |
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cerebellar Neoplasms; Combined Modality Therapy; Decitabine; Dideoxynucleosides; Epigenesis, Genetic; Humans; Hydroxamic Acids; Medulloblastoma; Mice; Neurogenesis; Radiation-Sensitizing Agents; Resveratrol; Stilbenes; Treatment Outcome; Tretinoin; Valproic Acid; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling.
Topics: Animals; Anticonvulsants; Benzoates; Cell Line, Tumor; Embryoid Bodies; Gastrulation; Gene Expression Regulation, Developmental; Histone Deacetylases; Mice; Receptors, Retinoic Acid; Signal Transduction; Stilbenes; Teratogens; Transcriptome; Tretinoin; Valproic Acid | 2016 |
Upregulation of CD54 and downregulation of HLA‑ABC contribute to the novel enhancement of the susceptibility of HL-60 cells to NK cell-mediated cytolysis induced by ATRA plus VPA.
Topics: Cells, Cultured; Cytotoxicity, Immunologic; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; HL-60 Cells; HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; Humans; Intercellular Adhesion Molecule-1; Killer Cells, Natural; Tretinoin; Up-Regulation; Valproic Acid | 2017 |
Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents.
Topics: Aged; Aged, 80 and over; Anemia; Antilymphocyte Serum; Antineoplastic Agents; Arsenic; Azacitidine; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclosporine; Cytarabine; Decitabine; Disease Progression; Enzyme Inhibitors; Erythrocyte Transfusion; Female; Hematinics; Humans; Hydroxyurea; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Recurrence; Retreatment; Retrospective Studies; Risk Factors; Survival Rate; Thalidomide; Treatment Failure; Tretinoin; Valproic Acid | 2017 |
Inhibiting glycogen synthase kinase-3 and transforming growth factor-β signaling to promote epithelial transition of human adipose mesenchymal stem cells.
Topics: Adipocytes; Adipose Tissue; Antigens, CD; Cadherins; Cell Movement; Enzyme Inhibitors; Epithelial Cell Adhesion Molecule; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Integrin alpha5; Mesenchymal Stem Cells; Occludin; Primary Cell Culture; Pyrazoles; Pyridines; Pyrimidines; Snail Family Transcription Factors; Thiosemicarbazones; Transforming Growth Factor beta1; Tranylcypromine; Tretinoin; Valproic Acid; Vimentin; Xenopus Proteins; Zinc Finger E-box-Binding Homeobox 1; Zonula Occludens-1 Protein | 2017 |
Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Computational Biology; Female; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Karyotype; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Pharmacogenomic Testing; Transcriptome; Treatment Outcome; Tretinoin; Valproic Acid | 2017 |
Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications.
Topics: Amyloid beta-Peptides; Cell Line; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Humans; Insulysin; Lead; Neprilysin; Tretinoin; Valproic Acid | 2019 |
Neural crest related gene transcript regulation by valproic acid analogues in the cardiac embryonic stem cell test.
Topics: Animals; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Gene Expression Regulation; Mice; Myocytes, Cardiac; Neural Crest; Tretinoin; Valproic Acid | 2019 |
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.
Topics: Aged; Aged, 80 and over; Amino Acids; Cytarabine; Drug Therapy; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Lipid Metabolism; Male; Mercaptopurine; Metabolomics; Middle Aged; Treatment Outcome; Tretinoin; Valproic Acid | 2019 |
Modifying gap junction communication in cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Cadherins; Cell Communication; Cell Line, Tumor; Cell Membrane; Connexins; Dexamethasone; Ganciclovir; Gap Junctions; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Molecular Targeted Therapy; Neoplasms; Tretinoin; Valproic Acid | 2021 |
Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Cell Lineage; Chick Embryo; Dexamethasone; Dose-Response Relationship, Drug; Embryoid Bodies; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Induced Pluripotent Stem Cells; Inhibitory Concentration 50; Myocytes, Cardiac; Neural Stem Cells; Neurogenesis; Risk Assessment; Teratogens; Toxicity Tests; Transcriptome; Tretinoin; Valproic Acid | 2021 |
Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Disease Eradication; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Leukemia, Promyelocytic, Acute; Mice; Oncogene Proteins, Fusion; Tretinoin; Valproic Acid | 2022 |
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Female; Fluorouracil; Hydroxyurea; Methotrexate; Mice; Molecular Docking Simulation; Network Pharmacology; Neural Tube Defects; Phosphatidylinositol 3-Kinases; Pregnancy; Tretinoin; Valproic Acid | 2022 |
Retinoic acid administration normalizes aberrant microglial activation via regulating TREM2 transcription in the PFC of valproic acid induced autism rat.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Microglia; Prefrontal Cortex; Rats; Retinoic Acid Receptor alpha; Tretinoin; Valproic Acid | 2023 |
Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway.
Topics: Cell Differentiation; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Neuroblastoma; Neurons; Tretinoin; Valproic Acid; Wnt Signaling Pathway | 2023 |
Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model.
Topics: Animals; Ataxia; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Dietary Supplements; Disease Models, Animal; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Tretinoin; Valproic Acid | 2023 |
Nervous system development related gene expression regulation in the zebrafish embryo after exposure to valproic acid and retinoic acid: A genome wide approach.
Topics: Animals; Biomarkers; Embryo, Nonmammalian; Gene Expression Regulation; Gene Expression Regulation, Developmental; Humans; Nervous System; Teratogens; Tretinoin; Valproic Acid; Zebrafish | 2023 |