valproic acid has been researched along with trans-2-en-valproate in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (21.62) | 18.7374 |
| 1990's | 23 (62.16) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbott, FS; Palaty, J | 1 |
| Brenstrum, T; Capretta, A; Kim, AJ; Ohnmacht, SA; Panna, E; Werstuck, GH | 1 |
| Bowes, AJ; Capretta, A; Gerritsma, D; Shi, Y; Werstuck, GH | 1 |
| Eadie, MJ; McKinnon, GE; McLaughlin, DB | 1 |
| Bialer, M; Hadad, S; van der Kleijn, E; Vree, TB | 1 |
| Hönack, D; Löscher, W; Nau, H; Wahnschaffe, U; Wittfoht, W | 1 |
| Drews, E; Nau, H; Wegner, C | 1 |
| Acuff-Smith, KD; Berry, JS; Minck, DR; Nau, H; Setchell, KD; Vorhees, CV; Weisenburger, WP | 1 |
| Klug, S; Lewandowski, C; Merker, HJ; Nau, H; Neubert, D; Zappel, F | 1 |
| Semmes, RL; Shen, DD | 1 |
| Frerman, F; Luder, AS; Parker, WD; Parks, JK | 1 |
| Keane, PE; Morre, M; Simiand, J | 1 |
| Klug, S; Lewandowski, C; Nau, H; Neubert, D | 1 |
| Nau, H | 1 |
| Nau, H; Scott, WJ | 1 |
| Löscher, W; Nau, H | 2 |
| Löscher, W; Marescaux, C; Nau, H; Vergnes, M | 1 |
| Bialer, M; Friedman, M; Rubinstein, A | 1 |
| Acuff-Smith, KD; Fisher, JE; Nau, H; Schilling, MA; Vorhees, CV | 1 |
| Baverel, G; Elhamri, M; Ferrier, B; Martin, M | 2 |
| Bolaños, JP; Medina, JM | 2 |
| Altrup, U; Lehmenkühler, A; Lücke, A; Nicholson, C; Reith, H; Schmitz-Moormann, C; Speckmann, EJ | 1 |
| Badir, K; Bialer, M; Hadad, S; Haj-Yehia, A | 1 |
| Baillie, TA; Davis, MR; Grillo, MP; Hu, P; Jin, L; Kassahun, K | 1 |
| Fekete, T; Gregus, Z; Klaassen, CD; Varga, F | 1 |
| Bojic, U; Hönack, D; Löscher, W; Nau, H; Rundfeldt, C; Wahnschaffe, U; Wittfoht, W | 1 |
| Hönack, D; Löscher, W | 1 |
| Loscher, W; McLean, MJ; Wamil, AW | 1 |
| Carlin, A; Simmons, J | 1 |
| Heinemann, U; Löscher, W; Schmitz, D; Sokolova, S; Zhang, CL | 1 |
| Abbott, FS; Kumar, S; Kwan, E; Riggs, KW; Rurak, DW; Wong, H | 1 |
| de Almeida, IT; Duran, M; IJlst, L; Jakobs, C; Ruiter, JP; Silva, MF; Wanders, RJ | 1 |
| Bialer, M; Eyal, S; Shimshoni, J; Yagen, B | 1 |
| Aires, CC; de Almeida, IT; Duran, M; Luís, PB; Silva, MF; Soveral, G; ten Brink, HJ; Wanders, RJ | 1 |
1 review(s) available for valproic acid and trans-2-en-valproate
| Article | Year |
|---|---|
Can we develop improved derivatives of valproic acid?
Topics: Animals; Anticonvulsants; Biotransformation; Drug Evaluation, Preclinical; Epilepsy; Fatty Acids, Monounsaturated; Prodrugs; Random Allocation; Stereoisomerism; Structure-Activity Relationship; Valproic Acid | 1994 |
36 other study(ies) available for valproic acid and trans-2-en-valproate
| Article | Year |
|---|---|
Structure-activity relationships of unsaturated analogues of valproic acid.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Mice; Seizures; Structure-Activity Relationship; Valproic Acid | 1995 |
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
Topics: Anticonvulsants; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Molecular Structure; Valproic Acid | 2004 |
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition.
Topics: Cell Line; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Histones; Humans; Molecular Chaperones; Molecular Structure; Structure-Activity Relationship; Valproic Acid | 2007 |
The influence of other anticonvulsants on the plasma concentration of E-2-en-valproate.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Humans; Middle Aged; Osmolar Concentration; Valproic Acid | 1992 |
Pharmacokinetic analysis of ester prodrugs of valproic acid.
Topics: Animals; Dogs; Drug Stability; Esters; Fatty Acids, Monounsaturated; Female; Injections, Intravenous; Male; Prodrugs; Valproic Acid | 1992 |
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. I. Biochemical, histopathological and pharmacokinetic studies.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Fatty Acids, Monounsaturated; Liver; Male; Rats; Rats, Sprague-Dawley; Valproic Acid | 1992 |
Zinc concentrations in mouse embryo and maternal plasma. Effect of valproic acid and nonteratogenic metabolite.
Topics: Animals; Decidua; Embryo, Mammalian; Fatty Acids, Monounsaturated; Female; Mice; Pregnancy; Valproic Acid; Zinc | 1990 |
Lack of teratogenicity of trans-2-ene-valproic acid compared to valproic acid in rats.
Topics: Animals; Body Weight; Embryo, Mammalian; Embryonic and Fetal Development; Fatty Acids, Monounsaturated; Female; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains; Teratogens; Valproic Acid | 1991 |
Effects of valproic acid, some of its metabolites and analogues on prenatal development of rats in vitro and comparison with effects in vivo.
Topics: Animals; Caproates; Culture Techniques; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Fatty Acids, Monounsaturated; Female; Pentanoic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Valproic Acid | 1990 |
Nonlinear binding of valproic acid (VPA) and E-delta 2-valproic acid to rat plasma proteins.
Topics: Animals; Blood Proteins; Buffers; Dialysis; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Humans; Liver; Male; Protein Binding; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1990 |
Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions.
Topics: Animals; Anticonvulsants; Brain; Cattle; Coenzyme A; Fatty Acids, Monounsaturated; Ketoglutarate Dehydrogenase Complex; Kinetics; NAD; Spectrum Analysis; Valproic Acid | 1990 |
Comparison of the pharmacological and biochemical profiles of valproic acid (VPA) and its cerebral metabolite (2-en-VPA) after oral administration in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Chemistry; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; gamma-Aminobutyric Acid; Kinetics; Mice; Valproic Acid | 1985 |
Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture.
Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Embryo, Mammalian; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; In Vitro Techniques; Kinetics; Protein Binding; Rats; Teratogens; Valproic Acid | 1986 |
Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse.
Topics: Administration, Oral; Animals; Anticonvulsants; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Gestational Age; Injections, Intraperitoneal; Injections, Subcutaneous; Kinetics; Maternal-Fetal Exchange; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1986 |
Teratogenicity of valproic acid and related substances in the mouse: drug accumulation and pHi in the embryo during organogenesis and structure-activity considerations.
Topics: Animals; Embryo, Mammalian; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrogen-Ion Concentration; Kinetics; Mice; Protein Binding; Teratogens; Valproic Acid | 1987 |
Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dogs; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1983 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Gerbillinae; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Pregnancy; Seizures; Species Specificity; Teratogens; Valproic Acid | 1984 |
Rapid gas chromatographic assay for monitoring valproic acid and valpromide in plasma.
Topics: Chromatography, Gas; Drug Stability; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Humans; Kinetics; Valproic Acid | 1984 |
Comparative transfer of valproic acid and of an active metabolite into brain and liver: possible pharmacological and toxicological consequences.
Topics: Animals; Brain; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Liver; Male; Mice; Mice, Inbred Strains; Protein Binding; Rats; Rats, Inbred Strains; Valproic Acid | 1984 |
Trans-2-ene-valproic acid is less behaviorally teratogenic than an equivalent dose of valproic acid in rats.
Topics: Animals; Behavior, Animal; Fatty Acids, Monounsaturated; Female; Maze Learning; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reflex, Startle; Teratogens; Therapeutic Equivalency; Valproic Acid | 1994 |
Effect of valproate and of two of its metabolites on renal substrate uptake and ammoniagenesis in the rat in vivo.
Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Kidney; Male; Rats; Valproic Acid | 1994 |
Inhibition of neonatal brain fuel utilization by valproate and E-delta 2-valproate is not a consequence of the stimulation of the gamma-aminobutyric acid shunt.
Topics: Animals; Animals, Newborn; Brain; Energy Metabolism; Fatty Acids, Monounsaturated; gamma-Aminobutyric Acid; Lactates; Lactic Acid; Rats; Rats, Wistar; Valproic Acid | 1994 |
Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat.
Topics: Agar; Animals; Cerebral Cortex; Diffusion; Extracellular Space; Fatty Acids, Monounsaturated; Male; Microelectrodes; Microinjections; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Valproic Acid | 1993 |
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography, Liquid; Coenzyme A; Fatty Acids, Monounsaturated; Glutathione; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Triglycerides; Valproic Acid | 1994 |
Effect of valproic acid on glycine conjugation of benzoic acid.
Topics: Animals; Anticonvulsants; Benzoates; Benzoic Acid; Fatty Acids, Monounsaturated; Glycine; Hippurates; Kidney; Liver; Male; Rats; Rats, Wistar; Valproic Acid | 1993 |
Effect of valproate, sodium 2-propyl-4-pentenoate and sodium 2-propyl-2-pentenoate on renal substrate uptake and ammoniagenesis in the rat.
Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Glomerular Filtration Rate; Ketone Bodies; Kidney; Male; Rats; Rats, Wistar; Renal Circulation; Stimulation, Chemical; Urodynamics; Valproic Acid | 1993 |
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. II. Influence of phenobarbital comedication.
Topics: Animals; Anticonvulsants; Drug Interactions; Fatty Acids, Monounsaturated; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Valproic Acid | 1993 |
Evidence of stimulation of the gamma-aminobutyric acid shunt by valproate and E-delta 2-valproate in neonatal rat brain.
Topics: Animals; Animals, Newborn; Brain; Fatty Acids, Monounsaturated; gamma-Aminobutyric Acid; Glucose; In Vitro Techniques; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Valproic Acid | 1993 |
Valproate and its major metabolite E-2-en-valproate induce different effects on behaviour and brain monoamine metabolism in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Dopamine; Fatty Acids, Monounsaturated; Female; Rats; Rats, Wistar; Serotonin; Valproic Acid | 1996 |
Trans-2-en-valproic acid limits action potential firing frequency in mouse central neurons in cell culture.
Topics: Action Potentials; Animals; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Mice; Neurons; Spinal Cord; Valproic Acid | 1997 |
Assay for valproic acid and its E-delta2 metabolite in rat plasma by capillary gas chromatography without prior derivatization.
Topics: Animals; Anticonvulsants; Chromatography, Gas; Drug Stability; Fatty Acids, Monounsaturated; Rats; Valproic Acid | 1997 |
Comparison of effects of valproate and trans-2-en-valproate on different forms of epileptiform activity in rat hippocampal and temporal cortex slices.
Topics: Action Potentials; Animals; Anticonvulsants; Electroencephalography; Entorhinal Cortex; Epilepsy; Extracellular Space; Fatty Acids, Monounsaturated; Hippocampus; Magnesium; Microelectrodes; Neurons; Rats; Synaptic Transmission; Temporal Lobe; Valproic Acid | 1998 |
Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep.
Topics: Age Factors; Animals; Anticonvulsants; Blood Proteins; Fatty Acids, Monounsaturated; Female; Glucuronic Acid; Metabolic Clearance Rate; Oxidation-Reduction; Sheep; Time Factors; Valproic Acid | 2000 |
Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.
Topics: Animals; Anticonvulsants; Cell Survival; Fatty Acids, Monounsaturated; Hepatocytes; Male; Myristic Acid; Oleic Acid; Oxidation-Reduction; Palmitic Acid; Phenylpropionates; Rats; Rats, Wistar; Tritium; Valproic Acid | 2001 |
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Histone Deacetylase Inhibitors; Humans; Pentanoic Acids; Structure-Activity Relationship; Valproic Acid | 2005 |
Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes.
Topics: Animals; Anticonvulsants; Biological Transport; Coenzyme A; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Liver; Male; Mitochondria, Liver; Mitochondrial Membranes; Oxidative Phosphorylation; Pyruvic Acid; Rats; Rats, Wistar; Valproic Acid | 2008 |