valproic acid and thyroxine

valproic acid has been researched along with thyroxine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19909 (23.68)18.7374
1990's7 (18.42)18.2507
2000's10 (26.32)29.6817
2010's12 (31.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Strassburg, CP; Tukey, RH1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Fichsel, H; Knöpfle, G1
Helenius, T; Liewendahl, K; Majuri, H1
Jones, TH1
Beastall, GH; Brodie, MJ; Larkin, JG; Macphee, GJ1
Kodama, S; Komatsu, M; Konishi, H; Matsuo, T; Momota, K; Tanaka, K; Yokoyama, S1
Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT1
Lerer, B1
Cathro, DM; Hardman, RP1
Elias, AN; Grossman, M; Szekeres, AV; Valenta, LJ1
Hayashi, A; Ishii, K; Mizusawa, H; Shoji, S; Tamaoka, A; Usuki, S1
Katic, M; Kutcher, SP; Papatheodorou, G; Szalai, JP1
Cai, Z; Liu, XM; Ruan, XZ; Zhu, SQ1
Flint, AJ; Gnam, W1
DeGolia, SG; Dunai, M; Ketter, TA; Strong, CM; Tate, DL; Winsberg, ME1
Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I1
Isojärvi, JI; Kotila, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Turkka, J1
Ferrier, IN1
Iyo, M; Nonomura, T1
Isojärvi, JI; Knip, M; Mikkonen, K; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Vainionpää, LK1
Becker, OV; Glenn, T; Ketter, TA; Marsh, WK; Rasgon, NL1
Anderson, G; Gill, SS; Lee, PE; Mamdani, M; Marras, C; Rochon, P; Shulman, KI; Sykora, K; Wodchis, WP1
de Vries, L; Goldberg-Stern, H; Karasik, A; Kiviti, S; Landau, Z; Phillip, M1
Chiarelli, F; Franzoni, E; Laus, M; Scardapane, A; Verrotti, A1
Byren, JC; Hurst, JA; Johnson, D; Kini, U; Wall, SA; Wilkie, AO1
Altshuler, LL; Frye, MA; Grunze, H; Keck, PE; Kupka, RW; Leverich, GS; Luckenbaugh, DA; McElroy, SL; Nolen, WA; Pizzarello, S; Post, RM; Rowe, M; Suppes, T1
de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE1
Arya, R; Gulati, S; Gupta, N; Gupta, YK; Kabra, M; Kaleekal, T; Reeta, Kh; Sahu, JK; Sharma, R1
Chae, JH; Chung, HR; Hwang, H; Hwang, YS; Kim, H; Kim, KJ; Kim, SH; Lim, BC1
Chauhan, S; Goyal, P; Kumar, D; Tripathi, P1
Arapoglu, M; Dalgıç, N; Kafadar, İ; Kılıç, BA; Yalçın, K1
Krysiak, R; Stojko, R1
Adzemovic, MZ; Berglund, R; Castelo-Branco, G; Falcão, AM; Gillett, A; Guerreiro-Cacais, AO; Hamza, KH; Hermanson, O; Jagodic, M; Lassmann, H; Marta, M; Stridh, P1

Reviews

5 review(s) available for valproic acid and thyroxine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Alternative therapies for bipolar disorder.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:8

    Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgyline; Demeclocycline; Fenfluramine; Humans; Methylene Blue; Phosphatidylcholines; Physostigmine; Propiophenones; Propranolol; Spironolactone; Thyroxine; Tryptophan; Valproic Acid

1985
Developments in mood stabilisers.
    British medical bulletin, 2001, Volume: 57

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Electroconvulsive Therapy; Electromagnetic Fields; Fructose; Humans; Lamotrigine; Lithium; Nipecotic Acids; Psychotherapy; Suicide Prevention; Thyroxine; Tiagabine; Topiramate; Triazines; Valproic Acid

2001
[Antidepressant induced rapid cycling].
    Ryoikibetsu shokogun shirizu, 2003, Issue:38

    Topics: Antidepressive Agents, Tricyclic; Antimanic Agents; Bipolar Disorder; Drug Therapy, Combination; Humans; Lithium; Risk Factors; Selective Serotonin Reuptake Inhibitors; Thyroxine; Valproic Acid

2003

Trials

2 trial(s) available for valproic acid and thyroxine

ArticleYear
The efficacy and safety of divalproex sodium in the treatment of acute mania in adolescents and young adults: an open clinical trial.
    Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Arousal; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydrocortisone; Liver Function Tests; Male; Personality Assessment; Psychiatric Status Rating Scales; Thyroxine; Treatment Outcome; Valproic Acid

1995
Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Follow-Up Studies; gamma-Glutamyltransferase; Humans; Oxcarbazepine; Thyroid Gland; Thyrotropin; Thyroxine; Valproic Acid; Withholding Treatment

2004

Other Studies

31 other study(ies) available for valproic acid and thyroxine

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Effects of anticonvulsant drugs on thyroid hormones in epileptic children.
    Epilepsia, 1978, Volume: 19, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Primidone; Protein Binding; Thyroid Function Tests; Thyroid Hormones; Thyrotropin; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine; Valproic Acid

1978
Thyroid function tests in patients on long-term treatment with various anticonvulsant drugs.
    Clinical endocrinology, 1978, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Carbamazepine; Female; Humans; Male; Middle Aged; Phenytoin; Primidone; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

1978
Sodium valproate-induced menstrual disturbance in young women.
    Hormone research, 1991, Volume: 35, Issue:2

    Topics: Adolescent; Amenorrhea; Epilepsy; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Oligomenorrhea; Thyroxine; Valproic Acid

1991
Thyroid hormone concentrations in epileptic patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Humans; Phenytoin; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

1989
Thyroid function in children with long-term anticonvulsant treatment.
    Pediatric neuroscience, 1987, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; Humans; Infant; Male; Osmolar Concentration; Phenobarbital; Resins, Plant; Thyroid Gland; Thyrotropin; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Valproic Acid

1987
The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.
    Postgraduate medical journal, 1987, Volume: 63, Issue:744

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Valproic Acid

1987
Sub-normal serum thyroxine levels associated with carbamazepine and valproic acid treatment.
    The Nebraska medical journal, 1985, Volume: 70, Issue:7

    Topics: Carbamazepine; Child; Diabetes Complications; Drug Therapy, Combination; Epilepsy; Humans; Male; Thyroxine; Valproic Acid

1985
Effect of di-N-propylacetic acid (valproic acid) on the TSH response to TRH--a presumptive role for gamma aminobutyric acid.
    Metabolism: clinical and experimental, 1981, Volume: 30, Issue:10

    Topics: 4-Aminobutyrate Transaminase; Adult; Female; gamma-Aminobutyric Acid; Humans; Hypothyroidism; Male; Middle Aged; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Valproic Acid

1981
Case report: thyrotropin-releasing hormone-induced myoclonus and tremor in a patient with Hashimoto's encephalopathy.
    The American journal of the medical sciences, 1995, Volume: 310, Issue:5

    Topics: Adult; Female; Humans; Menstrual Cycle; Myoclonus; Phenytoin; Prolactin; Thyroid Gland; Thyroiditis, Autoimmune; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Tremor; Valproic Acid

1995
Changes of thyroid hormone levels in epileptic patients.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1994, Volume: 14, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

1994
New onset rapid cycling bipolar disorder in an 87 year old woman.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:5

    Topics: Aged; Aged, 80 and over; Bipolar Disorder; Cerebral Infarction; Female; Humans; Hypothyroidism; Lithium Carbonate; Neurocognitive Disorders; Thyroxine; Valproic Acid

1993
Rapid efficacy of olanzapine augmentation in nonpsychotic bipolar mixed states.
    The Journal of clinical psychiatry, 1998, Volume: 59, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Lithium; Male; Middle Aged; Olanzapine; Pirenzepine; Thyroxine; Valproic Acid

1998
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
    Epilepsia, 1999, Volume: 40, Issue:12

    Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Male; Phenobarbital; Thyrotropin; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine; Valproic Acid

1999
Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Enzyme Induction; Epilepsy; gamma-Glutamyltransferase; Humans; Iodide Peroxidase; Liver; Male; Middle Aged; Oxcarbazepine; Radioimmunoassay; Sex Factors; Thyroglobulin; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

2001
Lamotrigine therapy in treatment-resistant menstrually-related rapid cycling bipolar disorder: a case report.
    Bipolar disorders, 2004, Volume: 6, Issue:5

    Topics: Adult; Antimanic Agents; Bipolar Disorder; Chronobiology Phenomena; Cyclohexanols; Drug Resistance; Female; Follicular Phase; Humans; Lamotrigine; Menstruation; Thyroxine; Triazines; Valproic Acid; Venlafaxine Hydrochloride

2004
New thyroxine treatment in older adults beginning lithium therapy: implications for clinical practice.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Cohort Studies; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Hypothyroidism; Incidence; Lithium Carbonate; Male; Observation; Population Surveillance; Thyroxine; Valproic Acid

2005
Endocrine effects of valproate in adolescent girls with epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Body Height; Body Mass Index; Child; Comorbidity; Epilepsy; Female; Humans; Menarche; Obesity; Polycystic Ovary Syndrome; Testosterone; Thyrotropin; Thyroxine; Valproic Acid

2007
Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate.
    European journal of endocrinology, 2009, Volume: 160, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Female; Humans; Linear Models; Male; Prospective Studies; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

2009
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
    American journal of medical genetics. Part A, 2010, Volume: 152A, Issue:6

    Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxaparin; Female; Humans; Male; Pregnancy; Pregnancy in Diabetics; Prenatal Exposure Delayed Effects; Thyroxine; Valproic Acid; Young Adult

2010
Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder.
    The Journal of clinical psychiatry, 2010, Volume: 71, Issue:9

    Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lithium Carbonate; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Secondary Prevention; Thyroxine; Treatment Outcome; Triiodothyronine; Valproic Acid

2010
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
    Clinical endocrinology, 2011, Volume: 75, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Hyperthyroidism; Hypothyroidism; Intellectual Disability; Lamotrigine; Linear Models; Male; Middle Aged; Netherlands; Phenobarbital; Phenytoin; Prevalence; Thyroid Gland; Thyrotropin; Thyroxine; Triazines; Triiodothyronine; Valproic Acid

2011
Evaluation of subclinical hypothyroidism in ambulatory children with controlled epilepsy on valproate monotherapy.
    Journal of child neurology, 2012, Volume: 27, Issue:5

    Topics: Adolescent; Ambulatory Care; Antibodies; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Electrochemical Techniques; Epilepsy; Female; Humans; Hypothyroidism; Iodide Peroxidase; Male; Retrospective Studies; Statistics, Nonparametric; Thyrotropin; Thyroxine; Time Factors; Valproic Acid

2012
Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy.
    Neuropediatrics, 2012, Volume: 43, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Hypothyroidism; Severity of Illness Index; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Valproic Acid

2012
Bipolar disorder in Pendred syndrome: a case report of two siblings.
    The Australian and New Zealand journal of psychiatry, 2014, Volume: 48, Issue:9

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Female; Goiter, Nodular; Hearing Loss, Sensorineural; Humans; Olanzapine; Siblings; Thyroxine; Treatment Outcome; Valproic Acid; Young Adult

2014
Evaluation of thyroid hormones in children receiving carbamazepine or valproate: a prospective study.
    Journal of child neurology, 2015, Volume: 30, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Prospective Studies; Statistics as Topic; Thyroid Hormones; Thyroxine; Time Factors; Triiodothyronine; Valproic Acid

2015
Transient hypothyroidism induced by anticonvulsant agents.
    Neuro endocrinology letters, 2014, Volume: 35, Issue:3

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hypothyroidism; Thyroxine; Trigeminal Neuralgia; Valproic Acid

2014
Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.
    Neurobiology of disease, 2014, Volume: 71

    Topics: Analysis of Variance; Animals; Brain; CD11b Antigen; CD4-Positive T-Lymphocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Flow Cytometry; Interleukin-17; Ki-67 Antigen; Myelin Basic Protein; Peptide Fragments; Rats; Thyroxine; Valproic Acid

2014