valproic acid and theophylline

valproic acid has been researched along with theophylline in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (21.95)	18.7374
1990's	9 (21.95)	18.2507
2000's	12 (29.27)	29.6817
2010's	10 (24.39)	24.3611
2020's	1 (2.44)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bermes, EW; Garbincius, J; Jandreski, MA; Shah, JC	1
Ahlers, AA; Nielsen, C	1
Aguado-Vega, M; Arranz Peña, MI; Rubí Cervino, J; Seijas Martínez-Echevarría, MV	1
Bachmann, KA; Forney, RB; Jauregui, L; Martin, M; Nunlee, M; Schwartz, J	1
Allain, P; Prémel-Cabic, A; Turcant, A	1
Baty, C; Jambou, J; Leducq, B; Richard, L	1
Hasegawa, T; Johno, I; Kitazawa, S; Ohshima, T	1
Buchanan, N	1
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C	2
Albrecht, CF; Brink, MS; Coetzee, AR; van der Merwe, AC	1
Albin, H; Bistue, C; Brachet-Liermain, A; Demotes-Mainard, F; Jarry, C; Vinçon, G	1
Lesko, LJ; Turo, TT	1
Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P	1
David, J; Joseph, T; Kulkarni, C	1
Borowicz, K; Czuczwar, SJ; Kleinrok, Z; Kozicka, M	1
Bachmann, KA; Jauregui, L	1
Gupta, YK; Malhotra, J	1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z	1
Bellomo, R; Bordoni, V; D'Intini, V; Dall'Olio, G; Galloni, E; Reiter, K; Ricatti, MG; Ronco, C; Ruperti, S; Soffiati, G; Soli, M	1
Chang, NC; Lee, TM; Lin, MS	1
Bruserud, O; Corbascio, M; Gjertsen, BT; Lassalle, P; Ryningen, A; Stapnes, C	1
Block, F; Dafotakis, M	1
Bruserud, O; Fredly, H; Gjertsen, BT; Reikvam, H	1
Jeanray, N; Martial, JA; Muller, M; Piot, A; Pruvot, B; Quiroz, Y; Voncken, A	1
Charlier, C; Dubois, N; Gilson, M; Sqalli, G	1

Reviews

3 review(s) available for valproic acid and theophylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Therapeutic drug monitoring in childhood. Australian paediatric journal, 1986, Volume: 22, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbamazepine; Child; Chloramphenicol; Digoxin; Drug Interactions; Half-Life; Humans; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Saliva; Theophylline; Valproic Acid	1986
[Drug-induced tremor]. Fortschritte der Neurologie-Psychiatrie, 2011, Volume: 79, Issue:10 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bronchodilator Agents; Cimetidine; Histamine H2 Antagonists; Humans; Immunosuppressive Agents; Lamotrigine; Lithium Compounds; Pindolol; Theophylline; Tremor; Triazines; Valproic Acid	2011

Trials

2 trial(s) available for valproic acid and theophylline

Article	Year
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3 Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid	1993
Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment. American journal of hematology, 2012, Volume: 87, Issue:4 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytokines; Female; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Middle Aged; Neoplasm Proteins; Palliative Care; Prognosis; Theophylline; Tretinoin; Tumor Cells, Cultured; Valproic Acid	2012

Article

Year

Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo.

Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3

Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid

1993

Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment.

American journal of hematology, 2012, Volume: 87, Issue:4

Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytokines; Female; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Middle Aged; Neoplasm Proteins; Palliative Care; Prognosis; Theophylline; Tretinoin; Tumor Cells, Cultured; Valproic Acid

2012

Other Studies

36 other study(ies) available for valproic acid and theophylline

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Clinical evaluation of five therapeutic drugs using dry film multilayer technology on the OPUS immunoassay system. Journal of clinical laboratory analysis, 1991, Volume: 5, Issue:6 Topics: Carbamazepine; Evaluation Studies as Topic; Humans; Immunoassay; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Reference Standards; Sensitivity and Specificity; Theophylline; Valproic Acid	1991
[Therapeutic monitoring of drug concentration in blood. Are the analyses correctly ordered?]. Ugeskrift for laeger, 1991, Apr-29, Volume: 153, Issue:18 Topics: Blood Chemical Analysis; Carbamazepine; Digoxin; Drug Administration Schedule; Humans; Lithium; Monitoring, Physiologic; Surveys and Questionnaires; Theophylline; Valproic Acid	1991
[Clinical use of pharmacologic monitoring at a hospital community]. Revista clinica espanola, 1990, Volume: 186, Issue:1 Topics: Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Utilization; Humans; Phenobarbital; Phenytoin; Product Surveillance, Postmarketing; Spain; Theophylline; Valproic Acid	1990
The use of single sample clearance estimates to probe hepatic drug metabolism: handprinting the influence of cigarette smoking on human hepatic drug metabolism. Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:5 Topics: Antipyrine; Carbamazepine; Glucuronosyltransferase; Humans; Liver; Lorazepam; Male; Metabolic Clearance Rate; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Polycyclic Compounds; Quinidine; Smoking; Theophylline; Valproic Acid	1990
Automated fluoroimmunoassay of theophylline and valproic acid by flow-injection analysis with use of HPLC instruments. Clinical chemistry, 1989, Volume: 35, Issue:3 Topics: Autoanalysis; Chromatography, Gas; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Immunoassay; Regression Analysis; Theophylline; Valproic Acid	1989
[Plasma determination of 7 common drugs by high performance liquid chromatography]. Annales de biologie clinique, 1989, Volume: 47, Issue:2 Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid	1989
Variations in protein binding of drugs in plasma and serum. Clinical chemistry, 1989, Volume: 35, Issue:8 Topics: Anticonvulsants; Blood Proteins; Carbamazepine; Chromatography, High Pressure Liquid; Fluoroimmunoassay; Humans; Hydrogen-Ion Concentration; Phenobarbital; Phenytoin; Protein Binding; Theophylline; Valproic Acid	1989
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. I. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Liver; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Rats; Rats, Inbred Strains; Theophylline; Valproic Acid; Warfarin	1988
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin	1988
Sodium valproate poisoning. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, May-04, Volume: 67, Issue:18 Topics: Adult; Hemoperfusion; Humans; Male; Theophylline; Time Factors; Valproic Acid	1985
[Determination of theophylline, phenobarbital and valproic acid by chromatographic and immunologic technics. Comparison of methods]. Annales de biologie clinique, 1984, Volume: 42, Issue:6 Topics: Chromatography; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Immunoassay; Immunoenzyme Techniques; Phenobarbital; Theophylline; Valproic Acid	1984
Extent of analyst bias in drug-assay results. American journal of hospital pharmacy, 1982, Volume: 39, Issue:3 Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Pharmaceutical Preparations; Quality Control; Theophylline; Valproic Acid	1982
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. Annals of emergency medicine, 1995, Volume: 25, Issue:3 Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Female; Half-Life; Linear Models; Metabolic Clearance Rate; Pharmacokinetics; Poisoning; Poisons; Prospective Studies; Random Allocation; Swine; Theophylline; Valproic Acid	1995
Involvement of adenosine in postictal events in rats given electroshock. Indian journal of physiology and pharmacology, 1994, Volume: 38, Issue:1 Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Electroshock; Female; Hindlimb; Male; Rats; Rats, Wistar; Seizures; Theophylline; Valproic Acid	1994
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice. Journal of neural transmission. General section, 1993, Volume: 93, Issue:2 Topics: Aminophylline; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Phenobarbital; Phenytoin; Seizures; Theophylline; Valproic Acid	1993
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. Indian journal of physiology and pharmacology, 1997, Volume: 41, Issue:3 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protective Agents; Rats; Rats, Wistar; Seizures; Theophylline; Valproic Acid	1997
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:4 Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Male; Rats; Rats, Wistar; Theophylline; Valproic Acid	2000
In vitro removal of therapeutic drugs with a novel adsorbent system. Blood purification, 2002, Volume: 20, Issue:4 Topics: Adsorption; Anti-Bacterial Agents; Biocompatible Materials; Carbamazepine; Digoxin; Glycopeptides; Hemoperfusion; Humans; Models, Biological; Phenobarbital; Phenytoin; Sorption Detoxification; Theophylline; Uremia; Valproic Acid	2002
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Blotting, Western; Cardiomegaly; Cell Size; Collagen; Coronary Vessels; Disease Models, Animal; Echocardiography; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Fibrosis; Histone Acetyltransferases; Histones; Immunohistochemistry; Ligation; Male; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Polymerase Chain Reaction; Rats; Rats, Wistar; Research Design; RNA, Messenger; Theophylline; Triglycerides; Valproic Acid; Ventricular Function, Left; Ventricular Remodeling	2007
A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid. Leukemia research, 2009, Volume: 33, Issue:6 Topics: Aged; Aged, 80 and over; Blood Cell Count; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Proteins; Proteoglycans; Risk Factors; Survival Analysis; Theophylline; Tretinoin; Valproic Acid	2009
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos. Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:4 Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish	2012
Analytical validation of a quantitative method for therapeutic drug monitoring on the Alinity Annales de biologie clinique, 2020, Apr-01, Volume: 78, Issue:2 Topics: Amikacin; Automation, Laboratory; Colorimetry; Drug Monitoring; Gentamicins; Humans; Immunoassay; Nephelometry and Turbidimetry; Phenobarbital; Phenytoin; Reproducibility of Results; Theophylline; Valproic Acid; Vancomycin	2020