valproic acid has been researched along with stiripentol in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 6 (20.69) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, Y; Chen, X; Cuan, Y; Ding, Y; Fan, TP; He, X; Jia, P; Li, B; Li, Y; Liang, J; Liao, S; Meng, X; Qin, F; Shan, G; Sun, Y; Wang, S; Wei, X; Wu, B; Xiao, C; Xie, J; Yu, J; Zeng, M; Zhang, Q; Zhang, Y; Zhao, Y; Zhao, Z; Zheng, X; Zhu, Z | 1 |
| Acheampong, A; Anderson, GD; Baillie, TA; Friel, PN; Guyot, M; Levy, RH; Loiseau, P; Rettenmeier, AW; Tor, J; Wilensky, AJ | 1 |
| Blehaut, H; Garat, A; Houin, G; Lachau, S; Montastruc, JL; Rascol, A; Rascol, O; Squalli, A; Tor, J | 1 |
| Chiron, C; d'Athis, P; Dulac, O; Marchand, MC; Pons, G; Rey, E; Tran, A; Vincent, J | 1 |
| Chiron, C; Dellatolas, G; Dulac, O; Pons, G; Rey, E; Thanh, TN; Vincent, J | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Trojnar, MK | 1 |
| Chancharme, L; Chugani, H; de Menezes, MS; Devinsky, O; Franz, DN; Hamiwka, L; Hernandez, A; Laux, L; Le Guern, ME; Mikati, MA; Morse, RP; Saneto, RP; Sullivan, J; Valencia, I; Wirrell, EC | 1 |
| Baraban, SC; Dinday, MT; Hortopan, GA | 1 |
| Inoue, Y; Ohtsuka, Y | 2 |
| Ito, S; Oguni, H | 1 |
| Chhun, S; Chiron, C; Dulac, O; Jullien, V; Pons, G; Rey, E; Tod, M | 1 |
| Specchio, N; Trivisano, M; Vigevano, F | 1 |
| Benninger, F; Dressler, A; Feucht, M; Grassl, R; Gröppel, G; Mühlebner, A; Reiter-Fink, E; Reithofer, E; Trimmel-Schwahofer, P | 1 |
| Aras, LM; Isla, J; Mingorance-Le Meur, A | 1 |
| Barnerias, C; Chemaly, N; Chiron, C; De Liso, P; Desguerre, I; Dulac, O; Hully, M; Laschet, J; Leunen, D; Nabbout, R | 1 |
| Fukuda, M; Imai, K; Inoue, Y; Jogamoto, T; Ohtsuka, Y; Suzuki, Y; Takahashi, Y; Yamamoto, Y | 1 |
| Hashimoto, T; Kitaoka, T; Kyotani, S; Morimoto, M; Shimakawa, S | 1 |
| Clifford, T; Coyle, D; Elliott, J; McCoy, B; Wells, GA | 1 |
| Boyd, B; Farfel, GM; Galer, BS; Gammaitoni, A; Smith, S | 1 |
| Blakey, G; Crockett, J; Morrison, G; Sommerville, K | 1 |
| Ikeda, H; Imai, K; Inoue, Y; Kagawa, Y; Takahashi, Y; Yamamoto, Y | 1 |
| Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S | 1 |
| Caraballo, RH; Cross, JH; Guerrini, R; Lagae, L; Nabbout, R; Vigevano, F | 1 |
| Arenas Cabrera, CM; Ben-Menachem, E; Critchley, D; Crockett, J; Gunning, B; Morrison, G; Tayo, B; Toledo, M; VanLandingham, K; Wray, L | 1 |
| Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E | 1 |
| Critchley, D; Gidal, B; Morrison, G; Patsalos, PN; Szaflarski, JP; VanLandingham, K | 1 |
| García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V | 1 |
4 review(s) available for valproic acid and stiripentol
| Article | Year |
|---|---|
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Substitution; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Patient Education as Topic; Piracetam; Practice Guidelines as Topic; Topiramate; Triazines; Triazoles; Valproic Acid | 2014 |
Dravet syndrome: Treatment options and management of prolonged seizures.
Topics: Anticonvulsants; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures; Valproic Acid | 2019 |
Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs.
Topics: Anticonvulsants; Cannabidiol; Clinical Trials as Topic; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Fatty Acids, Monounsaturated; Humans; Lennox Gastaut Syndrome; Valproic Acid | 2020 |
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Phenobarbital; Practice Guidelines as Topic; Pyrrolidinones; Spain; Triazoles; Valproic Acid | 2021 |
8 trial(s) available for valproic acid and stiripentol
| Article | Year |
|---|---|
A pilot study of stiripentol, a new anticonvulsant drug, in complex partial seizures uncontrolled by carbamazepine.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dioxolanes; Dioxoles; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Phenobarbital; Pilot Projects; Valproic Acid | 1989 |
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dioxolanes; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Male; Syndrome; Valproic Acid | 2000 |
[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dioxolanes; Epilepsies, Myoclonic; Female; Humans; Infant; Male; Severity of Illness Index; Treatment Outcome; Valproic Acid | 2002 |
Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Japan; Male; Treatment Outcome; Valproic Acid; Young Adult | 2014 |
Long-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Japan; Male; Treatment Outcome; Valproic Acid; Young Adult | 2015 |
A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects
.
Topics: Administration, Oral; Adult; Clobazam; Cross-Over Studies; Dioxolanes; Drug Interactions; Female; Fenfluramine; Healthy Volunteers; Humans; Male; Middle Aged; Non-Smokers; Valproic Acid; Young Adult | 2019 |
A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects.
Topics: Adult; Anticonvulsants; Cannabidiol; Clobazam; Cytochrome P-450 CYP2C19; Dioxolanes; Drug Interactions; Female; Genotype; Healthy Volunteers; Humans; Male; Valproic Acid | 2019 |
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Cannabidiol; Dioxolanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid; Young Adult | 2020 |
17 other study(ies) available for valproic acid and stiripentol
| Article | Year |
|---|---|
Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.
Topics: Allosteric Regulation; Animals; Anisoles; Anticonvulsants; Carbamazepine; Cinnamates; Dioxolanes; Drug Design; Drugs, Chinese Herbal; Esters; Humans; L-Lactate Dehydrogenase; Medicine, Chinese Traditional; Mice; Molecular Structure; Neuralgia; Polygala; Receptors, GABA-A; Structure-Activity Relationship; Valproic Acid | 2019 |
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid.
Topics: Adult; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; Drug Interactions; Enzyme Activation; Fatty Acids, Monounsaturated; Female; Humans; Liver; Male; Phenytoin; Valproic Acid | 1990 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2006 |
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepines; Brain Chemistry; Clobazam; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Hand Strength; Male; Mice; Motor Activity; Seizures; Valproic Acid | 2010 |
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Male; Retrospective Studies; Seizures; Treatment Outcome; United States; Valproic Acid | 2013 |
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinical; Epilepsies, Myoclonic; Gene Expression Profiling; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Potassium Compounds; Seizures; Valproic Acid; Voltage-Gated Sodium Channel beta-1 Subunit; Zebrafish; Zebrafish Proteins | 2013 |
Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid.
Topics: Anticonvulsants; Benzodiazepines; Body Weight; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Male; Prospective Studies; Randomized Controlled Trials as Topic; Valproic Acid | 2015 |
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cognition Disorders; Dioxolanes; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Female; Fever; Humans; Intellectual Disability; Protocadherins; Syndrome; Treatment Outcome; Valproic Acid | 2015 |
Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Bromides; Child; Child, Preschool; Clobazam; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Female; Fructose; Humans; Infant; Levetiracetam; Male; Piracetam; Retrospective Studies; Seizures; Topiramate; Treatment Outcome; Vagus Nerve Stimulation; Valproic Acid; Young Adult | 2015 |
The European patient with Dravet syndrome: results from a parent-reported survey on antiepileptic drug use in the European population with Dravet syndrome.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Epilepsies, Myoclonic; Europe; Female; Humans; Male; NAV1.1 Voltage-Gated Sodium Channel; Sodium Channel Blockers; Valproic Acid | 2015 |
Patients with dravet syndrome in the era of stiripentol: A French cohort cross-sectional study.
Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cross-Sectional Studies; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Follow-Up Studies; France; Humans; Male; NAV1.1 Voltage-Gated Sodium Channel; Severity of Illness Index; Treatment Failure; Valproic Acid; Young Adult | 2016 |
Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dioxolanes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Fructose; Humans; Infant; Male; Polymorphism, Genetic; Retrospective Studies; Topiramate; Valproic Acid | 2017 |
Marked efficacy of combined three-drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome.
Topics: Anticonvulsants; Child, Preschool; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Female; Fructose; Humans; Topiramate; Valproic Acid | 2018 |
Economic Evaluation of Stiripentol for Dravet Syndrome: A Cost-Utility Analysis.
Topics: Anticonvulsants; Canada; Child; Clobazam; Cost-Benefit Analysis; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Quality-Adjusted Life Years; Valproic Acid | 2018 |
Impact of CYP2C19 Phenotypes on Clinical Efficacy of Stiripentol in Japanese Patients With Dravet Syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; Dioxolanes; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Japan; Male; Retrospective Studies; Valproic Acid; Young Adult | 2020 |
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothiazoles; Brain; Dioxolanes; Epilepsy; Humans; Isoaspartic Acid; Neurons; PC12 Cells; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Structure-Activity Relationship; Valproic Acid | 2020 |
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Monitoring; Epilepsies, Myoclonic; Epilepsy; Female; Humans; Levetiracetam; Male; Middle Aged; Norway; Retrospective Studies; Valproic Acid; Young Adult | 2020 |