valproic acid and probenecid

valproic acid has been researched along with probenecid in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (8.57)	18.7374
1990's	6 (17.14)	18.2507
2000's	17 (48.57)	29.6817
2010's	8 (22.86)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Anlezark, GM; Horton, RW; Meldrum, BS; Sawaya, MC	1
Frey, HH; Löscher, W	1
Abed, WT	1
Bovell, M; Chung, T; Leake, J; MacMillan, V	1
Adkison, KD; Artru, AA; Powers, KM; Shen, DD	1
Brouwer, KR; Golden, PL; Pollack, GM	1
Hirano, H; Ichikawa, N; Iwamoto, K; Naora, K; Nishimura, N; Shen, DD	1
Iley, J; Mendes, E; Moreira, R; Souza, S	1
Artru, AA; Lewis, L; Powers, KM; Scism, JL; Shen, DD	1
Brouwer, KL; Pollack, GM; Ward, ES	2
Yeleswaram, S	1
Adeyeye, MC; Gibbs, JP; Shen, DD; Yang, Z	1
Hamada, N; Nagai, J; Ogawa, K; Takano, M; Yumoto, R	1

Reviews

3 review(s) available for valproic acid and probenecid

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

32 other study(ies) available for valproic acid and probenecid

Article	Year
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Monoamine and GABA metabolism and the anticonvulsant action of di-n-propylacetate and ethanolamine-O-sulphate. European journal of pharmacology, 1977, Feb-21, Volume: 41, Issue:4 Topics: Acoustic Stimulation; Aminobutyrates; Animals; Anticonvulsants; Biogenic Amines; Brain Chemistry; Drug Interactions; Ethanolamines; Fenclonine; gamma-Aminobutyric Acid; Methyltyrosines; Mice; Mice, Inbred DBA; Probenecid; Valerates; Valproic Acid	1977
Distribution of valproate across the interface between blood and cerebrospinal fluid. Neuropharmacology, 1978, Volume: 17, Issue:8 Topics: Acidosis; Animals; Dogs; Drug Interactions; Female; Kinetics; Male; Phenylbutazone; Probenecid; Protein Binding; Time Factors; Valproic Acid	1978
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat. Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:1 Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Pentylenetetrazole; Probenecid; Rats; Rats, Inbred Strains; Serotonin; Valproic Acid	1990
The effect of valproic acid on the 5-hydroxyindoleacetic, homovanillic and lactic acid levels of cerebrospinal fluid. Brain research, 1987, Sep-15, Volume: 420, Issue:2 Topics: Animals; Anticonvulsants; Brain; Chlorpromazine; Dose-Response Relationship, Drug; Homovanillic Acid; Hydroxyindoleacetic Acid; Lactates; Lactic Acid; Male; Probenecid; Rats; Rats, Inbred Strains; Valproic Acid	1987
Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: Animals; Biological Transport; Brain; Choroid Plexus; Endothelium, Vascular; Male; Probenecid; Rabbits; Valproic Acid	1994
Assessment of valproic acid serum-cerebrospinal fluid transport by microdialysis. Pharmaceutical research, 1993, Volume: 10, Issue:12 Topics: Animals; Infusions, Intravenous; Injections, Intravenous; Male; Microdialysis; Models, Biological; Probenecid; Rats; Rats, Sprague-Dawley; Valproic Acid	1993
Saturable transport of valproic acid in rat choroid plexus in vitro. Journal of pharmaceutical sciences, 1996, Volume: 85, Issue:4 Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport, Active; Choroid Plexus; Cold Temperature; Dinitrophenols; In Vitro Techniques; Male; Probenecid; Rats; Rats, Sprague-Dawley; Uncoupling Agents; Valproic Acid	1996
Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999, Volume: 9, Issue:2 Topics: Amides; Animals; Benzoic Acid; Carboxylic Acids; Clofibric Acid; Diclofenac; Drug Interactions; Esters; Hydrolases; Hydrolysis; Ibuprofen; In Vitro Techniques; Liver; Male; Naproxen; Physostigmine; Proadifen; Probenecid; Prodrugs; Rats; Rats, Sprague-Dawley; Refractometry; Solubility; Structure-Activity Relationship; Time Factors; Valproic Acid	1999
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study. Brain research, 2000, Nov-24, Volume: 884, Issue:1--2 Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Carrier Proteins; Cell Membrane; Drug Interactions; Epilepsy; Extracellular Space; Intracellular Fluid; Ion Pumps; Male; Microdialysis; Neuroglia; Neurons; Probenecid; Rabbits; Valproic Acid	2000
Probenecid-associated alterations in valproic acid pharmacokinetics in rats: can in vivo disposition of valproate glucuronide be predicted from in vitro formation data? Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:12 Topics: Algorithms; Animals; Anticonvulsants; Cytosol; Glucuronides; Male; Probenecid; Protein Binding; Rats; Rats, Sprague-Dawley; Renal Agents; Tissue Distribution; Valproic Acid	2000
Probenecid-associated alterations in valproate glucuronide hepatobiliary disposition: mechanistic assessment using mathematical modeling. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Bile; Glucuronides; Liver; Male; Mathematics; Models, Biological; Perfusion; Probenecid; Rats; Rats, Sprague-Dawley; Valproic Acid	2001
Probenecid-associated alterations in valproic acid pharmacokinetics in rats: can in vivo disposition of valproate glucuronide be predicted from in vitro formation data? Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:5 Topics: Animals; Anticonvulsants; Probenecid; Rats; Uricosuric Agents; Valproic Acid	2001
Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport. Epilepsy research, 2004, Volume: 58, Issue:1 Topics: Adenocarcinoma; Animals; Biological Transport, Active; Brain; Cattle; Cells, Cultured; Cyclooxygenase Inhibitors; Dinitrophenols; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Fluoresceins; GABA Agents; Humans; Indomethacin; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Pancreatic Neoplasms; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotenone; Temperature; Tritium; Uncoupling Agents; Uricosuric Agents; Valproic Acid	2004
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy research, 2006, Volume: 71, Issue:1 Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Glutathione; Indomethacin; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Transport Vesicles; Valproic Acid	2006