valproic acid has been researched along with phenobarbital in 780 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 297 (38.08) | 18.7374 |
| 1990's | 199 (25.51) | 18.2507 |
| 2000's | 143 (18.33) | 29.6817 |
| 2010's | 107 (13.72) | 24.3611 |
| 2020's | 34 (4.36) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, H; Edafiogho, IO; Hinko, CN; Moore, JA; Mulzac, D; Nicholson, JM; Scott, KR | 1 |
| Johnson, DN; Kilpatrick, BF; Kinnier, WB; Lo, YS; Moses, LM; Sutherland, DB; Taylor, CR; Tomczuk, BE | 1 |
| Kohn, H; Leander, JD; LeGall, P; Robertson, DW; Sawhney, KN | 1 |
| Edafiogho, IO; Farrar, VA; Moore, JA; Nicholson, JM; Scott, KR | 1 |
| Baron, BM; Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM; Staeger, MA | 1 |
| Conley, JD; Kohn, H; Leander, JD; LeGall, P; Robertson, DW; Sawhney, KN | 1 |
| Goehring, RR; Greenwood, TD; Nwokogu, GC; Pisipati, JS; Rogers, TG; Wolfe, JF | 1 |
| Baker, JK; Wall, GM | 1 |
| Kadaba, PK | 1 |
| Clark, CR; Lin, CM; Sansom, RT | 1 |
| Conley, JD; Kohn, H | 1 |
| Clark, CR; Lin, CM; Norris, GN; Sansom, RT | 1 |
| Bardel, P; Bolanos, A; Kohn, H | 1 |
| Bardel, P; Kohn, H; Leander, JD; Robertson, DW; Sawhney, KN | 1 |
| Ciechanowicz-Rutkowska, M; Edafiogho, IO; el-Assadi, A; Farrar, VA; Filippini, G; Grochowski, J; Hinko, CN; Moore, JA; Pilati, T; Serda, P | 1 |
| Covey, DF; Ferrendelli, JA; Hill, MW; Hsiang, BC; Latifi, TN; Reddy, PA; Rothman, SM; Woodward, KE | 1 |
| Choi, D; Kohn, H; Stables, JP | 1 |
| Flaherty, PT; Greenwood, TD; Manheim, AL; Wolfe, JF | 1 |
| Covey, DF; Ferrendelli, JA; Hill, MW; Hsiang, BC; Latifi, TN; McIlheran, SM; Reddy, PA; Rothman, SM; Woodward, KE | 1 |
| Cacciaguerra, S; Delarge, J; Depovere, P; Isa, M; Masereel, B; Poupaert, JH; Spampinato, S; Stables, JP; Ucar, H; Van derpoorten, K | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Andurkar, SV; Béguin, C; Kohn, H; Stables, JP | 1 |
| Kohn, H; LeTiran, A; Stables, JP | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Chai, KY; Kwak, KC; Piao, HR; Quan, ZS; Xie, ZF | 1 |
| Pavana, RK; Raghavendran, JV; Sriram, D; Stables, J; Sudhan, K; Thirumurugan, R; Yogeeswari, P | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Alkskas, IA; Azam, F; Khokra, SL; Prakash, O | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Kohn, H; Morieux, P; Park, KD; Salomé, C; Stables, JP | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| De Ryck, M; Dinsmore, J; Kaminski, R; King, AM; Kohn, H; Salomé, C; Salomé-Grosjean, E; Valade, A | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| He, X; Hu, X; Wu, W; Wu, Z; Xiao, Y; Zhang, T; Zhong, M | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Dustrude, ET; Khanna, R; Kohn, H; Lee, H; Park, KD; Wilson, SM; Yang, XF | 1 |
| Kumari, S; Mishra, CB; Tiwari, M | 1 |
| Cummins, TR; Dustrude, ET; Khanna, R; Kohn, H; Torregrosa, R; Yang, XF | 1 |
| Edayadulla, N; Ramesh, P | 1 |
| Karcz, T; Karolak-Wojciechowska, J; Kieć-Kononowicz, K; Kuder, K; Latacz, G; Schwed, JS; Stark, H; Łażewska, D | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Akhtar, MJ; Bhatia, R; Grover, G; Nath, R | 1 |
| Roger, J; Tassinari, CA | 1 |
| Richens, A | 2 |
| Buchthal, A | 1 |
| Egli, M | 1 |
| Dreifuss, FE | 2 |
| Flachs, H; Gram, L; Parnas, J | 1 |
| Penin, H | 1 |
| Koskiniemi, M; Palo, J | 1 |
| Bruni, J; Wilder, BJ | 1 |
| Boenigk, HE; May, T; Rambeck, B | 1 |
| Livingston, S; Pauli, LL; Pruce, I | 1 |
| Sauer, W; Windorfer, A | 1 |
| Brett, E | 1 |
| Stünkel, S; Weinmann, HM; Windorfer, A | 1 |
| Trompetter-van Woerden, ML; van der Zwan, A | 1 |
| Flachs, H; Gram, L; Lohren, V; Rasmussen, KE; Sommerbeck, KW; Wulff, K; Würtz-Jorgensen, A | 1 |
| Leviel, V; Naquet, R | 1 |
| Massimo, L; Pasino, M; Perutelli, P; Rosanda Vadalá, C; Saccomani, L; Tonini, GP | 1 |
| Johannessen, SI | 1 |
| Araki, Y; Ueki, S; Watanabe, S | 1 |
| Aucamp, AK; Joubert, PH; Potgieter, GM; Verster, F | 1 |
| Fowler, GW; Julien, RM | 1 |
| Jeavons, PM | 1 |
| Klotz, U | 1 |
| Hori, M; Ito, T; Shimizu, M; Yoshida, K | 3 |
| Da Silva, V; Pavlincova, E; Rüdeberg, A; Vassella, F | 1 |
| Fröscher, W; Gugler, R; Schulz, HU | 1 |
| Fowler, GW | 1 |
| Conomy, JP | 1 |
| Göbel, W; Löscher, W | 1 |
| Farinotti, R; Mahuzier, G; Pfaff, MC | 1 |
| Levy, RH; Patel, IH | 1 |
| Bruni, J | 3 |
| Newmark, ME; Penry, JK | 1 |
| Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA | 1 |
| Andersen, B; Flachs, H; Gram, L; Parnas, J; Würtz-Jørgensen, A | 1 |
| Reith, H; Schäfer, H | 1 |
| Curless, RG | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 1 |
| Deisenhammer, E; Sommer, R | 1 |
| Wada, JA | 1 |
| Hosokawa, K; Kugoh, T; Otsuki, S | 1 |
| Brachet, A; Henry, P; Loiseau, P | 1 |
| Dumas, M; Girard, PL; Papy, JJ | 1 |
| Frey, HH; Löscher, W | 2 |
| Boucharlat, PJ; Ledru, J; Maitre, A; Ratel, M | 1 |
| Gabreëls, FJ; Schobben, F; van der Kleijn, E | 1 |
| Gastaut, H; Osuntokun, BO | 1 |
| Boxer, CM; Herzberg, JL; Scott, DF | 1 |
| Dam, M; Hvidberg, EF | 1 |
| Hassan, MN; Laljee, HC; Parsonage, MJ | 1 |
| Kaplan, ER; Sapeika, N | 1 |
| Cash, C; Ciesielski, L; Maitre, M; Mandel, P | 1 |
| Coulthard, MG | 1 |
| Ahmad, S; Richens, A | 1 |
| Mares, P; Stanková, L | 1 |
| Fukuchi, H; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Tanaka, N | 2 |
| Watanabe, M; Yagi, K | 1 |
| Fukusako, T; Morimatsu, M; Nogaki, H; Yamamoto, K | 1 |
| Akaike, N; Kameda, H; Kataoka, M; Takahashi, K; Ueno, S | 1 |
| De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR | 1 |
| Di Capua, M; Fusco, L; Lucchini, P; Ricci, S; Sebastianelli, R; Vigevano, F | 1 |
| Fujii, T; Ito, M; Mikawa, H; Nozaki, K; Okuno, T; Shirasaka, Y | 1 |
| Theodore, WH | 1 |
| Churchyard, A; Grainger, K; Khangure, M | 1 |
| Baruzzi, A; Di Sarro, R; Gallassi, R; Lugaresi, E; Marra, M; Morreale, A | 1 |
| Anderson, GD; Levy, RH | 1 |
| Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W | 1 |
| Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S | 1 |
| Cheymol, G; Lebot, M; Poirier, JM | 1 |
| Cornel, MC; Lindhout, D; Omtzigt, JG | 1 |
| Friel, PN; McCormick, K; Yerby, MS | 1 |
| Benedetti, TJ; Erickson, DM; Leavitt, A; Loewenson, RB; McCormick, KB; Sells, CJ; Yerby, MS | 1 |
| Dravet, C; Genton, P; Giraud, N; Guerrini, R; Julian, C; Legras, C; Magaudda, A; Mesdjian, E; Soulayrol, S; Trentin, G | 1 |
| Lindhout, D; Meijer, JW; Meinardi, H; Nau, H | 1 |
| Baba, A; Hori, T; Kawai, N; Koizumi, J; Moroji, T; Shiraishi, H; Suzuki, T; Tada, K | 1 |
| Fujita, T; Takano, K; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Declerck, AC; Wauquier, A | 1 |
| Clarke, BM; Griffin, H; Hudoba, P; Upton, A | 1 |
| Breimer, DD; de Boer, AG; van Hoogdalem, E | 1 |
| Lluch Fernández, MD; Montoya García, MJ; Peña Griñán, MJ; Pérez Cano, R; Ramos Sánchez, I | 1 |
| Burlina, A; Mould, GP; Müller, C; Stamp, RJ | 1 |
| Bermes, EW; Garbincius, J; Jandreski, MA; Shah, JC | 1 |
| Baruchello, M; Brignolio, F; Verzè, L | 1 |
| Czuczwar, SJ; Dziki, M; Kleinrok, Z; Turski, WA; Urbańska, E | 1 |
| Besser, R; Krämer, G | 1 |
| Gil-Salú, JL; Gómez-Cárdenas, E; Gonzàlez-Darder, JM; Guerrero, M; Segura-Pastor, D | 1 |
| Fredow, G; Löscher, W | 1 |
| Foster, GR; Freeth, CJ; Goldin, RD; Nieman, E; Oliveira, DB | 1 |
| Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA | 1 |
| Alonso, C; Camiña, MF; Gómez, M; Paz, JM; Rodriguez-Segade, S; Rozas, I | 1 |
| Alonso, C; Camiña, MF; Castro-Gago, M; Paz, JM; Rodriguez-Segade, S; Rozas, I | 1 |
| Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H | 1 |
| McNamara, JO; Shin, C; Silver, JM | 1 |
| Bates, SR; Hug, G; Landrigan, EA; McGraw, CA | 1 |
| Giardina, M; Pacifici, R; Paris, L; Pichini, S; Sideri, G; Zuccaro, P | 1 |
| Löscher, W; Wahnschaffe, U | 1 |
| Holmes, GL | 1 |
| Smith, DB | 1 |
| Hönack, D; Löscher, W; Wahnschaffe, U | 1 |
| Blazquez, A; Calandre, EP; Cano, D; Rodriquez-Lopez, C | 1 |
| Albani, F; Baruzzi, A; Campostrini, R; Galli, G; Paganini, M; Riva, R; Zaccara, G | 1 |
| Jenkins, DC; Lai, CW; Leppik, IE; Sood, P | 1 |
| Lustman, LI; Maccario, M | 1 |
| Aguado-Vega, M; Arranz Peña, MI; Rubí Cervino, J; Seijas Martínez-Echevarría, MV | 1 |
| Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA | 1 |
| Chen, SS; Shen, MR | 1 |
| Matisová, E; Pham Thi, Ha; Volmut, J | 1 |
| Calandre, EP; Dominguez-Granados, R; Gomez-Rubio, M; Molina-Font, JA | 1 |
| Addy, DP | 2 |
| Cosgrove, M; Pople, S; Wallace, SJ | 1 |
| Kahn, D; Schneier, HA | 1 |
| Endo, K; Hagimoto, H; Ishii, M; Miyauchi, T; Tanaka, K; Yamaguchi, T | 1 |
| Armon, C; Brown, E; Carwile, S; Miller, P; Shin, C | 1 |
| Bausch, S; Blackwood, J; Gassmann, S; Grün, K; Inbar, S; Kreider, R; Löchel, B; Siebert, M; Walter, G | 1 |
| Czuczwar, SJ; Kleinrok, Z; Małek, U | 1 |
| Bun, H; Cano, JP; Durand, A; Monjanel-Mouterde, S; Noel, F | 1 |
| Jürgens, U; May, T; Rambeck, B; Schnabel, R; Villagrán, R | 1 |
| Trimble, MR | 1 |
| Hirose, S; Jibiki, I; Kubota, T; Yamaguchi, N | 1 |
| Aoyama, T; Higuchi, S; Hirata, K; Ichikou, N; Ieiri, I; Yamada, H | 1 |
| Aoyama, T; Higuchi, S; Hirata, K; Ieiri, I; Yamada, H | 1 |
| Macdonald, RL; McLean, MJ; Skerritt, JH | 1 |
| Garcia de la Serrana, H; Mota, C; Puche, E; Saucedo, R | 1 |
| Blehaut, H; Garat, A; Houin, G; Lachau, S; Montastruc, JL; Rascol, A; Rascol, O; Squalli, A; Tor, J | 1 |
| Leary, PM; Luss, K | 1 |
| Baty, C; Jambou, J; Leducq, B; Richard, L | 1 |
| de la Peña, CA; Del Río, R; Fernandez, MP; Paz, JM; Rodriguez-Segade, S; Rozas, I; Tutor, JC | 1 |
| Hayakawa, T; Matsui, Y; Mogami, H; Okamoto, Y; Shimizu, K; Tamura, K; Yamada, M | 1 |
| Hasegawa, T; Johno, I; Kitazawa, S; Ohshima, T | 1 |
| Morrow, JI; Routledge, PA | 1 |
| McKinlay, I; Newton, R | 1 |
| Horibe, Y; Ito, Y; Iwaki, M; Ogiso, T; Yoneda, I | 1 |
| Aoyama, T; Higuchi, S; Yukawa, E | 1 |
| Murthy, VS; Reynolds, NC | 1 |
| Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL | 1 |
| Fukuyama, Y; Hara, H | 1 |
| Cennamo, M; Piccione, E; Ticconi, C | 1 |
| Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y | 1 |
| Morselli, PL | 1 |
| Iri, H; Kano, S; Kikuchi, H; Matsumoto, K; Takahashi, H; Umino, M | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A | 1 |
| Dow, KE; Riopelle, RJ | 1 |
| Aburada, M; Hosoya, E; Iizuka, S; Ishige, A; Matsuzaki, Y; Sakamoto, K; Sekiguchi, K; Sugaya, E | 1 |
| Clayton, RM; Sedowofia, SK | 1 |
| Bender, AS; Hertz, L | 1 |
| Samanin, R; Tullii, M; Vezzani, A; Wu, HQ | 1 |
| Hartshorn, EA; Hartshorn, JC | 1 |
| Kodama, S; Komatsu, M; Konishi, H; Matsuo, T; Momota, K; Tanaka, K; Wada, H; Yokoyama, S | 1 |
| Dewhurst, DG | 1 |
| Lloyd, KG | 1 |
| Kishita, C | 1 |
| Gal, J; Molitoris, BA; Nakata, LM; Sedman, AJ | 1 |
| Nau, H | 1 |
| Buchanan, N | 1 |
| Nandedkar, AK; Sobrian, SK | 1 |
| Berry, DJ; Newbery, JE; Pettit, LI; Streete, JM | 1 |
| Endsley, B; Leibold, L; Picker, M; Poling, A | 1 |
| Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H | 1 |
| Baciewicz, AM | 1 |
| Bova, VE | 1 |
| Bentley, M; Feely, M; Gent, JP; Haigh, JR | 1 |
| Belknap, JK; Crabbe, JC; Kosobud, A; Laursen, SE; Tam, B; Young, ER | 1 |
| Lee, EK; Walters, JR; Waszczak, BL | 1 |
| Mondadori, C; Schmutz, M | 1 |
| de la Iglesia, FA; DiFonzo, CJ; Martin, RA; Sturgess, JM; Walker, RM | 1 |
| Ishigooka, J; Murasaki, M; Takahashi, A; Wakatabe, H; Yoshida, Y | 1 |
| Karas, CA; Picker, M; Poling, A | 1 |
| Freed, WJ; Schwarz, SS | 1 |
| Shinnar, S | 1 |
| Kodama, S; Komatsu, M; Konishi, H; Matsuo, T; Sadahiro, N; Tanaka, K; Yokoyama, S | 1 |
| Haidukewych, D; John, G | 1 |
| Alonso Gonzalez, AC; Dominguez-Gil Hurle, A; Fernandez de Gatta, MR; Garcia Sanchez, MJ; Monzon Corral, L; Santos Borbujo, J | 1 |
| Meyer, FP; Walther, H | 1 |
| Bertollini, R; Källen, B; Mastroiacovo, P; Robert, E | 1 |
| Cataldo, MF; Dorsen, MM; Freeman, JM; Mellitis, ED; Quaskey, SA; Spielberg, SP; Vining, EP | 1 |
| De Jongh, KS; Edwards, MR; Schofield, PJ; Smith, MM | 1 |
| Bradford, L; Calvert, R; Cooke, J; Feely, M; Mehta, A; Price, D; Singleton, S | 1 |
| Trimble, R | 1 |
| Ballinger, BR; Fenton, GW; Sheppard, LC | 1 |
| Rosman, NP | 1 |
| Kodama, S; Komatsu, M; Konishi, H; Matsuo, T; Momota, K; Tanaka, K; Yokoyama, S | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
| Mimaki, T; Onoe, S; Seino, Y; Yabuuchi, H; Yamaoka, K; Yamashita, G | 1 |
| Baraldi, E; Carani, C; Ciccarone, V; Galli, V; Grandi, F; Nalin, A | 1 |
| Baillie, TA; Boberg, M; Rettenmeier, AW; Rettie, AE | 1 |
| Krall, RL; Resor, SJ | 1 |
| Newton, RW | 1 |
| Bourgeois, BF | 3 |
| Lindhout, D; Reuss, A; Sachs, ES; Stewart, PA; van Swaay, E; Wladimiroff, JW | 1 |
| Comi, G; Ferini-Strambi, L; Filippi, M; Giusti, MC; Medaglini, S; Poggi, A; Smirne, S | 1 |
| Hobusch, D; Popp, K; Rohmann, E; Schwebke, D; Sengbusch, S | 1 |
| Heinemeyer, G; Hildebrandt, AG; Nau, H; Roots, I | 1 |
| Kuhnz, W; Löscher, W; Nau, H | 1 |
| Kutt, H | 2 |
| Koch, C; Picker, M; Poling, A; Thomas, J | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Levy, RH; Yerby, MS | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Ishizaki, T; Kushida, K | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Arnetoli, G; Bartelli, M; Campostrini, R; Messori, A; Moroni, F; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R | 1 |
| Canevini, MP; Canger, R; Cornaggia, C; Giuccioli, D; Pinelli, P; Pruneri, C | 1 |
| Picker, M; Poling, A; White, W | 1 |
| Burgess, RJ; Drake, ME; Paulson, GW | 1 |
| Baier, WK; Dieterich, E; Doose, H; Fichsel, H; Tuxhorn, I | 1 |
| Haidukewych, D; John, G; Rodin, EA; Zielinski, JJ | 1 |
| Brodie, MJ | 2 |
| Kodama, S; Komatsu, M; Matsui, T; Matsuo, T; Sadahiro, N | 1 |
| Freeman, JM; Vining, EP | 2 |
| May, T; Rambeck, B | 1 |
| Abbott, LC; Bennett, GD; Finnell, RH; Taylor, SM | 1 |
| Beran, RG; Lewis, JH; Nolte, JL; Westwood, AP | 1 |
| Carpenter, CL; Cooper, EC; Greenberg, DA | 1 |
| Laird, H; Mimaki, T; Yabuuchi, H; Yamamura, HI | 1 |
| Lascelles, PT; Patsalos, PN | 4 |
| Jacobi, G; Janssen, W; Ritz, A; Schmidts, HL; Thorbeck, R | 1 |
| Tollefson, G | 1 |
| Alterthum, K; Bauer, P; Stünkel, S; Windorfer, A | 1 |
| Kosoĭ, MIu | 1 |
| Voronina, TA | 1 |
| Maheshwari, MC | 1 |
| Lassen, JB; Petersen, EN | 1 |
| Battistin, L; Bracco, F; Gabana, MA; Maggioni, F; Saladini, M; Zanchin, G | 1 |
| Pei, YQ | 1 |
| Polc, P | 1 |
| Schmidt, D | 4 |
| Deisenhammer, E; Schwarzbach, H; Sommer, R | 1 |
| Neuvonen, PJ; Tokola, RA | 1 |
| Hosokawa, K; Kugoh, T | 1 |
| Boréus, LO; Lundberg, B; Nergårdh, A | 1 |
| Mantegazza, P; Martini, A; Panerai, AE; Sacerdote, P | 1 |
| Gallagher, JP; Inokuchi, H; Nakamura, J; Shinnick-Gallagher, P | 1 |
| Friel, PN; Koch, KM; Levy, RH; Lockard, JS; Maris, DO | 1 |
| Imler, M; Koehl, C; Kurtz, D; Laroye, M; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM | 1 |
| Harel, S; Heldenberg, D; Holtzman, M; Levtow, O; Tamir, I | 1 |
| Crawford, KD; Crawford, RD; Johnson, DD | 1 |
| Rowan, AJ | 1 |
| Bruni, J; Somerville, ER | 1 |
| Crema, A; Perucca, E | 1 |
| Chapman, AG; Meldrum, BS | 1 |
| Albani, F; Baruzzi, A; Cortelli, P; Gobbi, G; Perucca, E; Riva, R | 1 |
| Escorihuela, R; Sandiumenge, J | 1 |
| Fukuda, T; Fukushima, Y; Kuroki, Y | 1 |
| Sonawane, BR; Yaffe, SJ | 1 |
| Brandt, C; Chabrier, G; Imler, M; Kurtz, D; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM | 1 |
| Cloyd, JC; Graves, NM; Welty, TE | 1 |
| Procopis, PG | 1 |
| Alvira Duplá, R; Ara Callizo, JR; Cid López, A; Gracia Naya, M; López Gastón, J; Oliveros Juste, A; Otal Castán, M | 1 |
| Aymard, P; Taburet, AM | 1 |
| Kuhnz, W; Nau, H; Zierer, R | 1 |
| Bleck, TP | 1 |
| Applegarth, DA; Farrell, K; Kirby, LT; Verity, CM | 1 |
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| Eadie, MJ | 1 |
| Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH | 1 |
| Faye, M; Gueye Diagne, MC; N'Diaye, M; SarrNiang, NT; Yam, AA | 1 |
| Borowicz, KK; Czernecki, R; Czuczwar, SJ; Luszczki, JJ; Wojtal, K | 1 |
| Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K | 1 |
| Dirik, E; Kurul, S; Unalp, A | 1 |
| Bottomley, SS; Bronze, MS; Dhaliwal, G; Jackson, R; Toubia, N | 1 |
| Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y | 1 |
| Amonkou, AA; Brouh, Y; Ndjeundo, PG; Pete, Y; Tetchi, YD; Yapobi, Y | 1 |
| Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Amakata, K; Fujii, Y; Hikita, T; Kaga, F; Kaneko, S; Kodama, H; Nakamoto, N; Ogita, K; Yanagawa, Y | 1 |
| Fujii, Y; Fujita, Y; Hikita, T; Igarashi, K; Kaneko, S; Kodama, H; Nakamoto, N; Ogita, K; Suzuki, Y; Yanagawa, Y | 1 |
| Chwalczuk, K; Czuczwar, SJ; Rubaj, A; Swiader, M | 1 |
| Cai, F; Cao, J; Chen, J; Li, S; Zhang, X | 1 |
| Czuczwar, SJ; Kocharov, SL; Luszczki, JJ | 1 |
| Chen, X; He, L; Li, Q; Zhou, D | 1 |
| Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Minetti, C; Striano, P; Striano, S; Zara, F | 1 |
| Aleksunes, LM; Corton, JC; George, MH; Klaassen, CD; Ren, H; Vallanat, B; Wood, C | 1 |
| Trinka, E | 1 |
| Baghel, R; Bala, K; Gourie-Devi, M; Grover, S; Gupta, M; Kaur, H; Kukreti, R; Sharma, S; Talwar, P | 1 |
| Cheng, M; Huang, Z; Li, SX | 1 |
| Caraballo, R; Cersósimo, R; Flesler, S; Sakr, D | 1 |
| Andres-Mach, M; Cioczek, JD; Kocharov, SL; Kominek, M; Luszczki, JJ; Zolkowska, D | 1 |
| Lang, SY; Shi, XB; Tian, HJ; Wang, RF; Wang, XQ; Yang, F | 1 |
| Jankovic, S; Jankovic, SM; Milovanovic, JR | 1 |
| Ammendola, E; Arcieri, S; Coppola, G; D'Aniello, A; Della Corte, R; Operto, FF; Pascotto, A; Verrotti, A | 1 |
| Genton, P; Velizarova, R | 1 |
| Gulati, S; Lodha, R; Raj, D | 1 |
| Czuczwar, SJ; Florek, M; Luszczki, JJ; Misiuta-Krzesinska, M; Tutka, P | 1 |
| Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R | 1 |
| de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE | 1 |
| Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH | 1 |
| Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F | 2 |
| Gomez-Ibañez, A; Urrestarazu-Bolumburu, E; Viteri-Torres, C | 1 |
| Andres-Mach, M; Barcicka-Klosowska, B; Czuczwar, SJ; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ | 1 |
| Li, YP; Zeng, LN; Zhang, LL | 1 |
| Kotov, AS; Rudakova, IG | 1 |
| Klapková, E; Komárek, V; Tesfaye, H; Tesfayeová, A | 1 |
| Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A | 1 |
| Conti, E; Difrancesco, JC; Ferrarese, C; Galimberti, G; Riva, C; Rodriguez-Menendez, V; Ruffmann, C; Tremolizzo, L | 1 |
| Dhingra, K; Prakash, S | 1 |
| Eley, B; Petersen, R; Samia, P; Walker, KG; Wilmshurst, JM | 1 |
| Li, S; Ru, X; Sander, JW; Wang, W; Wu, J; Zheng, J; Zhu, S | 1 |
| Abbott, FS; Chang, TK; Surendradoss, J | 1 |
| Bialer, M | 1 |
| Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A | 1 |
| Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R | 1 |
| Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C | 1 |
| Greenhalgh, J; Marson, AG; Pulman, J | 1 |
| Brizendine, CE; Naik, PJ | 1 |
| Alexander, JM; Wilson, KL | 1 |
| Awa, HD; Chelo, D; Kinkela, MN; Ndombo, PO | 1 |
| Barrera-Bailón, B; Garcia-Cairasco, N; López, DE; Muñoz, LJ; Oliveira, JA; Sancho, C | 1 |
| Cayir, A; Ozden, O; Tan, H; Turan, MI | 1 |
| Bongiovanni, LG; Brigo, F; Igwe, SC; Nardone, R; Tezzon, F; Trinka, E | 1 |
| Jabłoński, M; Majdan, M; Nowicka-Stążka, P; Parada-Turska, J; Rzeski, W; Turski, WA | 1 |
| Panomvana, D; Towanabut, S; Traiyawong, T | 1 |
| Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM | 1 |
| Adachi, A; Chihara, K; Hino, Y; Ibusuki, C; Kimura, K; Nakamura, S; Suematsu, N; Takahashi, N; Takata, M | 1 |
| Chen, XY; He, L; Li, Q; Zhou, D | 1 |
| Chiarelli, F; Cofini, M; Scaparrotta, A; Tiboni, GM; Verrotti, A | 1 |
| Borowicz, KK; Borowicz, KM; Latalski, M; Zarczuk, R | 1 |
| Czuczwar, SJ; Świąder, MJ | 1 |
| Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A | 1 |
| Lubszky, S; Reinhart, WH; Schulzki, T; Thöny, S | 1 |
| Golubović, B; Jovanović, M; Kovačević, SV; Martinović, Ž; Miljković, B; Prostran, M; Vučićević, K | 1 |
| Bankstahl, M; Klein, S; Löscher, W | 1 |
| Andres-Mach, M; Baumann, MH; Luszczki, JJ; Prisinzano, TE; Zolkowska, D | 1 |
| Greenhalgh, J; Marson, AG; Weston, J | 1 |
| Egusa, M; Higuchi, H; Ishii-Maruhama, M; Maeda, S; Miyawaki, T; Tomoyasu, Y | 1 |
| Florek-Luszczki, M; Glensk, M; Glowniak, K; Luszczki, JJ; Pyrka, D; Skalicka-Wozniak, K; Zagaja, M | 1 |
| Bamford, A; Clarke, A; Crowe, BH; Hacohen, Y; Lim, M; Lin, JP; Pullaperuma, SP; Sancho-Shimizu, V; Tudor-Williams, G; Vincent, A | 1 |
| Jimeno, FJ; Manso, G; Ordoñez, L; Salgueiro, E | 1 |
| Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT | 1 |
| Borowicz, KK; Popławska, M; Wróblewska, D | 1 |
| Beaud, N; Borggraefe, I; Budde, J; Debus, O; Ensslen, M; Geis, T; Gilbert, M; Haeussler, M; Hahn, A; Hehr, U; Heiming, R; Herbst, SM; Kurlemann, G; Morgner, R; Morris-Rosendahl, DJ; Muelleder, K; Philippi, H; Proepper, CR; Ross, S; Schuierer, G; Strobl-Wildemann, G; von Gersdorff, G; Vosschulte, P | 1 |
| Andermann, E; Andermann, F; de la Loge, C; Frucht, SJ; Genton, P; Gerard, D; Kälviäinen, R; Magaudda, A; Schlit, AF; von Rosenstiel, P | 1 |
| Banach, M; Borowicz-Reutt, KK; Piskorska, B | 2 |
| Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW | 1 |
| Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M | 1 |
| Löscher, W; Töllner, K; Twele, F | 1 |
| Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H | 1 |
| Bártfai, G; Devosa, I; Szok, D; Vanya, M | 1 |
| Al-Qudah, AA; Alabbadi, I; Albsoul-Younes, A; Gharaibeh, L; Masri, A; Murtaja, AA | 1 |
| Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Florek-Łuszczki, M; Kondrat-Wróbel, MW; Tutka, P; Zaluska, K; Żółkowska, D; Łuszczki, JJ | 1 |
| Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y | 1 |
| Badrane, N; Bencheikh, RS; Moussa, LA; Ouammi, L; Serragui, S; Tanani, DS; Zalagh, F | 1 |
| Schoemaker, R; Stockis, A; Wade, JR | 1 |
| Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J | 2 |
| Fontaine, GV; Fraser, GL; Gagnon, DJ; Riker, RR | 1 |
| Andres-Mach, M; Chmielewski, J; Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Patrzylas, P; Szpringer, M; Zagaja, M; Zaluska, K | 1 |
| Brown, H; Dionisio, S; Gillinder, L; Lehn, A | 1 |
| Güngör, O; Özkaya, AK; Temiz, F | 1 |
| Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F | 1 |
| Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J | 2 |
| Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S | 1 |
| de Baat, C; Vissink, A; Zweers, PGMA | 1 |
| Chmielewski, J; Daniluk, J; Florek-Łuszczki, M; Karwan, S; Sawicka, KM; Wawryniuk, A; Łuszczki, JJ | 1 |
| Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| Başardı Gökçe, A; Demirel Yılmaz, B; Eren, B; Eren, Z; Sağır, D | 1 |
| Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G | 1 |
| Baudou, E; Cances, C; Dimeglio, C; Hachon Lecamus, C | 1 |
| Gaínza-Lein, M; Lamb, N; Loddenkemper, T; Sánchez Fernández, I | 1 |
| Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y | 1 |
| Li, J; Li, N; Lin, W; Yang, D; Zhao, D | 1 |
| Ouchi, K | 1 |
| Colebunders, R; Delahaye, L; Hotterbeekx, A; Idro, R; Mandro, M; Ogwang, R; Stove, CP; Velghe, S | 1 |
| Ardinger, CE; Beske, PH; Bodner, PM; Dubée, PB; Dunn, EN; Eisen, MR; Haines, KM; Honnold, CL; McCarren, HS; McDonough, JH; McNutt, PM; Nguyen, DL; Ondeck, CA; Santoro, AN | 1 |
| Charlier, C; Dubois, N; Gilson, M; Sqalli, G | 1 |
| Limotai, C; Limotai, N; Mokklaew, J; Pattanasilp, B; Phayaph, N | 1 |
| Barker-Haliski, M; Knox, KM; Koneval, Z; Memon, A; White, HS; Zierath, DK | 1 |
| Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G | 1 |
| Banach, M; Borowicz-Reutt, KK | 1 |
| Demir, O; Kaplan, YC | 1 |
| García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V | 1 |
| Ding, L; Huang, H; Jiang, M; Jiang, W; Pan, S; Su, Y; Zhang, L; Zhuang, X | 1 |
| Bishop, C; Bonkovsky, HL; Ma, CD; Van Horn, CG; Wan, M | 1 |
| Pavuluri, S; Schmidt, CM; Situ-Kcomt, M; Snehal, I; Taraschenko, O; Zhou, DJ | 1 |
| Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R | 1 |
| Amrithum, LM; Bhaskar, D; George, B; Jeemon, P; Jose, M; Nair, MKC; Thomas, SV | 1 |
| Allegaert, K; Yalcin, N | 1 |
| Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J | 1 |
| Battino, D; Bromley, R; Kochen, S; Meador, KJ; Pennell, PB; Thomas, SV; Tomson, T | 1 |
| Aneja, S; Arya, R; Cunningham, J; Jain, P; Sharma, S | 1 |
| García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V | 1 |
| Banach, M; Borowicz-Reutt, K | 1 |
| Biliaminu, SA; N Adeboye, MA; Ojuawo, A; Omefe, PN | 1 |
| Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ | 1 |
| Bernat, P; Kołodziejczyk, P; Tutka, P; Zagaja, M; Łuszczki, JJ | 1 |
| Ito, Y; Miki, K; Morishita, R; Moroi, S; Nakajima, T; Oyama, A; Rakugi, H; Shimamura, M; Sugihara, N; Takami, Y; Takeda, S; Takeya, Y | 1 |
| Chen, B; He, F; Kessi, M; Peng, J; Shan, LD; Wang, G; Wang, Y; Yang, L; Yin, F | 1 |
| Jiang, R; Mei, S; Zhang, D; Zhao, Z | 1 |
| Chen, W; Huang, H; Jiang, M; Liu, G; Su, Y; Tian, F; Wang, Y; Zhang, Y | 1 |
| Aricò, M; Di Noia, SP; Kalolo, A; Mabusi, MS; Mastrangelo, M; Pisani, F | 1 |
| Czabanka, M; Kieslich, M; Merker, M; Purwien, L; Ronellenfitsch, MW; Rosenow, F; Schubert-Bast, S; Strzelczyk, A; Willems, LM | 1 |
108 review(s) available for valproic acid and phenobarbital
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Humans; Molecular Structure; Seizures; Structure-Activity Relationship | 2020 |
Interactions with antiepileptic drugs.
Topics: Acetaminophen; Acetazolamide; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Furosemide; Gonadal Steroid Hormones; Griseofulvin; Humans; Phenobarbital; Phenytoin; Primidone; Thiazines; Urea; Valproic Acid; Vitamin D | 1977 |
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Succinimides; Thiazines; Valproic Acid | 1978 |
Psychotropic effect of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Ethosuximide; Humans; Mental Processes; Personality Inventory; Phenobarbital; Phenytoin; Psychiatric Status Rating Scales; Psychotropic Drugs; Thiazines; Valproic Acid | 1979 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Term Care; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1978 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Half-Life; Humans; Intestinal Absorption; Mice; Phenobarbital; Phenytoin; Seizures; Sleep Stages; Valproic Acid | 1979 |
The medical treatment of epilepsy: initiation of drug therapy.
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Humans; Hydantoins; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1979 |
[Laboratory controls in long-term treatment with anticonvulsive drugs (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Intestinal Absorption; Male; Phenobarbital; Phenytoin; Primidone; Time Factors; Valproic Acid | 1977 |
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Salicylates; Sulfadimethoxine; Valerates; Valproic Acid | 1978 |
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans; Kinetics; Lactation; Maternal-Fetal Exchange; Nitrazepam; Phenobarbital; Phenytoin; Pregnancy; Primidone; Valproic Acid | 1979 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; Female; Humans; Male; Mutation; Phenobarbital; Phenytoin; Photic Stimulation; Primidone; Seizures; Valproic Acid | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carbamazepine; Catecholamines; Cats; Cerebral Cortex; Chlorpromazine; Clorazepate Dipotassium; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Haplorhini; Hydroxydopamines; Phenobarbital; Phenytoin; Rats; Reserpine; Seizures; Valproic Acid | 1977 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam; Diazepam; Drug Interactions; Ethosuximide; Female; Humans; Hydantoins; Infant, Newborn; Injections, Intramuscular; Injections, Intravenous; Intestinal Absorption; Kidney Diseases; Kinetics; Liver Diseases; Milk; Molecular Biology; Phenobarbital; Phenytoin; Pregnancy; Primidone; Valproic Acid | 1976 |
[Neurotoxicity of antiepileptic drugs].
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Ethosuximide; Humans; Male; Nervous System; Nervous System Diseases; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1992 |
Rational use of antiepileptic drug levels.
Topics: Carbamazepine; Half-Life; Humans; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1992 |
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.
Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid | 1991 |
[Phosphorus-calcium metabolism in children under prolonged treatment with anticonvulsants. (II)].
Topics: Anticonvulsants; Calcium; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Phenobarbital; Phosphorus; Valproic Acid | 1991 |
Cognitive effects of antiepileptic drugs.
Topics: Anticonvulsants; Brain Diseases; Carbamazepine; Cognition; Drug Tolerance; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Phenobarbitone and febrile convulsions.
Topics: Humans; Infant; Intelligence; Phenobarbital; Seizures, Febrile; Time Factors; Valproic Acid | 1990 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phenytoin; Psychological Tests; Research Design; Valproic Acid | 1990 |
Poisoning by anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1989 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; Female; Fetus; Haloperidol; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione; Valproic Acid | 1989 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
Therapeutic drug monitoring in childhood.
Topics: Aminoglycosides; Anti-Bacterial Agents; Carbamazepine; Child; Chloramphenicol; Digoxin; Drug Interactions; Half-Life; Humans; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Saliva; Theophylline; Valproic Acid | 1986 |
Carbamazepine drug interactions.
Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin | 1986 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Interactions; Epilepsy; Ethosuximide; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Primidone; Sports; Valproic Acid | 1987 |
Febrile seizures.
Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Nitrazepam; Phenobarbital; Risk Factors; Seizures, Febrile; Valproic Acid | 1987 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1987 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; Epilepsy; Ethosuximide; Kinetics; Phenobarbital; Phenytoin; Primidone; Species Specificity; Trimethadione; Valproic Acid | 1985 |
[Advance and clinic of antiepileptic drugs (author's transl)].
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mice; Neurotransmitter Agents; Phenobarbital; Phenytoin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1981 |
Diagnosis and treatment of epilepsy.
Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Ethosuximide; Humans; Muscle Tonus; Phenobarbital; Phenytoin; Primidone; Telemetry; Valproic Acid | 1983 |
Effects of anticonvulsant drugs on brain amino acid metabolism.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Benzodiazepines; Biomechanical Phenomena; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Glutamates; Glycine; Humans; Neural Inhibition; Phenobarbital; Synapses; Valproic Acid | 1983 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurrence; Risk; Seizures, Febrile; Valproic Acid | 1983 |
Therapy for status epilepticus.
Topics: Acetazolamide; Anesthesia; Anticonvulsants; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Ethosuximide; Humans; Lidocaine; Lorazepam; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticus; Valproic Acid | 1983 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Half-Life; Humans; Intestinal Absorption; Kidney; Kidney Diseases; Kinetics; Liver Diseases; Phenobarbital; Phenytoin; Pregnancy; Primidone; Protein Binding; Tissue Distribution; Trimethadione; Valproic Acid | 1984 |
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological Availability; Child; Child, Preschool; Female; Fetus; Humans; Infant; Infant, Newborn; Kinetics; Maternal-Fetal Exchange; Metoclopramide; Otitis Media; Otitis Media with Effusion; Pediatrics; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Pregnancy; Reye Syndrome; Salamandridae; Seizures; Tourette Syndrome; Toxicology; Valproic Acid | 1983 |
Interactions between anticonvulsants and other commonly prescribed drugs.
Topics: Analgesics; Anti-Infective Agents; Anticoagulants; Anticonvulsants; Benzodiazepines; Biotransformation; Carbamazepine; Drug Interactions; Humans; Intestinal Absorption; Kinetics; Phenobarbital; Phenytoin; Primidone; Protein Binding; Psychotropic Drugs; Succinimides; Sulfonamides; Tissue Distribution; Valproic Acid | 1984 |
Sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kinetics; Phenobarbital; Seizures; Structure-Activity Relationship; Valproic Acid | 1980 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; Humans; Kinetics; Phenobarbital; Phenytoin; Pregnancy; Primidone; Saliva; Valproic Acid | 1980 |
Pharmacological principles in the long-term treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long-Term Care; Phenobarbital; Phenytoin; Primidone; Succinimides; Valproic Acid | 1981 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Maternal-Fetal Exchange; Milk, Human; Phenobarbital; Phenytoin; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Protein Binding; Status Epilepticus; Valproic Acid | 1982 |
Antiepileptic therapeutic drug monitoring.
Topics: Anticonvulsants; Carbamazepine; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1981 |
Valproic acid: interactions with phenytoin and phenobarbital.
Topics: Binding, Competitive; Drug Interactions; Half-Life; Humans; Kinetics; Phenobarbital; Phenytoin; Protein Binding; Seizures; Valproic Acid | 1982 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseases; Phenobarbital; Phenytoin; Valproic Acid | 1982 |
Drug interactions with valproic acid.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethosuximide; Fatty Acids, Nonesterified; Humans; Kinetics; Phenobarbital; Phenytoin; Primidone; Salicylates; Valproic Acid | 1982 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 1994 |
Standard approach to antiepileptic drug treatment in the United States.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Drug Administration Schedule; Drug Therapy, Combination; Drug Utilization; Epilepsy; Ethosuximide; Humans; Medicine; Phenobarbital; Specialization; United States; Valproic Acid | 1994 |
Standard approach to antiepileptic drug treatment in the United Kingdom.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin; Prognosis; United Kingdom; Valproic Acid | 1994 |
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Humans; Mice; Phenobarbital; Phenytoin; Treatment Outcome; Valproic Acid | 1994 |
Valproate-induced coma: case report and literature review.
Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid | 1993 |
Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Infant; Infant, Newborn; Phenobarbital; Primidone; Succinimides; Valproic Acid | 1995 |
Clinically significant pharmacokinetic drug interactions with carbamazepine. An update.
Topics: Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Carbamazepine; Drug Interactions; Ethosuximide; Felbamate; Humans; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Valproic Acid | 1996 |
A meta-analytic review of the preventive treatment of recurrences of febrile seizures.
Topics: Anticonvulsants; Chi-Square Distribution; Child; Diazepam; Drug Administration Schedule; Fever; Humans; Odds Ratio; Phenobarbital; Phenytoin; Pyridoxine; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Seizures, Febrile; Valproic Acid | 1997 |
Antiepileptic drug review: part 1.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Drug Interactions; Half-Life; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1998 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexanecarboxylic Acids; Diazepam; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Mephenytoin; Pentobarbital; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Seizures; Valproic Acid | 1998 |
Standards of laboratory practice: antiepileptic drug monitoring. National Academy of Clinical Biochemistry.
Topics: Anticonvulsants; Blood Specimen Collection; Carbamazepine; Drug Interactions; Drug Monitoring; Humans; Phenobarbital; Phenytoin; Primidone; Quality Control; Valproic Acid | 1998 |
A mechanistic approach to antiepileptic drug interactions.
Topics: Acetates; Amines; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cyclohexanecarboxylic Acids; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glucuronosyltransferase; Humans; Lamotrigine; Mixed Function Oxygenases; Nipecotic Acids; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 1998 |
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Practice Patterns, Physicians'; Triazines; Valproic Acid; Vigabatrin | 1999 |
Treatment of children with simple febrile seizures: the AAP practice parameter. American Academy of Pediatrics.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Male; Pediatrics; Phenobarbital; Risk Assessment; Secondary Prevention; Seizures, Febrile; United States; Valproic Acid | 2000 |
Therapeutic safety monitoring: what to look for and when to look for it.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Topiramate; Triazines; Valproic Acid; Vigabatrin | 2000 |
[Febrile convulsions, Treatment and prognosis].
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Primidone; Prognosis; Recurrence; Seizures, Febrile; Time Factors; Valproic Acid | 2001 |
Status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Midazolam; Phenobarbital; Phenytoin; Propofol; Status Epilepticus; Valproic Acid | 2001 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; Diazepam; Epilepsy; Humans; Lorazepam; Models, Statistical; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Risk; Seizures; Treatment Outcome; Valproic Acid | 2001 |
Prevention and management of febrile seizures.
Topics: Anticonvulsants; Child, Preschool; Humans; Incidence; Infant; Phenobarbital; Randomized Controlled Trials as Topic; Risk Factors; Seizures; United States; Valproic Acid | 2001 |
The current state of treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Electroencephalography; Female; GABA Modulators; Humans; Midazolam; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Status Epilepticus; Treatment Outcome; Valproic Acid | 2002 |
[Epilepsy with GTCs on awakening].
Topics: Adolescent; Adult; Child; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Prognosis; Syndrome; Valproic Acid; Wakefulness | 2002 |
[Other generalized epilepsies not defined above].
Topics: Diagnosis, Differential; Epilepsy, Generalized; Humans; Phenobarbital; Prognosis; Syndrome; Valproic Acid | 2002 |
New management strategies in the treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Emergency Medical Services; Humans; Phenobarbital; Phenytoin; Status Epilepticus; United States; Valproic Acid | 2003 |
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats; Risk Factors; Valproic Acid | 2005 |
Seizure prophylaxis in patients with brain tumors: a meta-analysis.
Topics: Anticonvulsants; Brain Neoplasms; Comorbidity; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Incidence; Male; Odds Ratio; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Risk Assessment; Seizures; Treatment Failure; Valproic Acid | 2004 |
Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison.
Topics: Animals; Biological Transport; Carbamazepine; Embryonic Development; Female; Humans; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Placenta; Pregnancy; Rabbits; Rats; Salicylic Acid; Species Specificity; Teratogens; Toxicity Tests; Tretinoin; Valproic Acid; Yolk Sac | 2004 |
Therapeutic monitoring of antiepileptic drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 2007 |
Pharmacokinetics of antiepileptic drugs in elderly nursing home residents.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Nursing Homes; Phenobarbital; Phenytoin; Valproic Acid | 2007 |
[Neuromuscular disorders caused by adverse effects of antiepileptics].
Topics: Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Neuromuscular Diseases; Phenobarbital; Phenytoin; Topiramate; Valproic Acid; Zonisamide | 2007 |
The treatment of the first seizure: the benefits.
Topics: Actuarial Analysis; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Secondary Prevention; Treatment Outcome; Valproic Acid | 2008 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 2008 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Humans; Lamotrigine; Mice; Nipecotic Acids; Phenobarbital; Phenytoin; Seizures; Tiagabine; Triazines; Valproic Acid | 2007 |
Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese Traditional; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Valproic Acid | 2009 |
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Topics: Animals; Clofibrate; Constitutive Androstane Receptor; Diethylhexyl Phthalate; Gene Expression Profiling; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; Phenobarbital; Plasticizers; PPAR alpha; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Valproic Acid | 2010 |
What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam?
Topics: Anticonvulsants; Benzodiazepines; Humans; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Prodrugs; Status Epilepticus; Treatment Outcome; Valproic Acid | 2009 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data Collection; Data Interpretation, Statistical; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Pregnancy; Randomized Controlled Trials as Topic; Research; Research Design; Treatment Outcome; Valproic Acid | 2011 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Induction Chemotherapy; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Recurrence; Seizures; Time Factors; Valproic Acid | 2013 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2013 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; Heparin; Humans; Infant, Newborn; Intracranial Hemorrhages; Lamotrigine; Monitoring, Physiologic; North America; Phenobarbital; Phenytoin; Pregnancy; Risk Factors; Seizures; Subarachnoid Hemorrhage; Triazines; Valproic Acid; Vitamin K | 2013 |
A common reference-based indirect comparison meta-analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus.
Topics: Algorithms; Anticonvulsants; Bias; Humans; Injections, Intravenous; Models, Statistical; Phenobarbital; Randomized Controlled Trials as Topic; Research Design; Status Epilepticus; Treatment Outcome; Valproic Acid | 2013 |
WITHDRAWN: Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese Traditional; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Valproic Acid | 2014 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabilities; Female; Humans; Lamotrigine; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Triazines; Valproic Acid | 2014 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2015 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Oxcarbazepine; Parturition; Perinatal Care; Phenobarbital; Phenytoin; Piracetam; Preconception Care; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Teratogens; Triazines; Valproic Acid | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
Repurposing Valproate, Enteral Clonidine, and Phenobarbital for Comfort in Adult ICU Patients: A Literature Review with Practical Considerations.
Topics: Administration, Oral; Administration, Sublingual; Adult; Clonidine; Critical Illness; Drug Repositioning; Humans; Hypnotics and Sedatives; Intensive Care Units; Patient Comfort; Phenobarbital; Valproic Acid | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Incidence; Infant; Male; Phenobarbital; Thyroid Gland; Thyroid Hormones; Valproic Acid | 2020 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2018 |
[Medicaments and oral healthcare. Proliferation of the gingiva].
Topics: Anticonvulsants; Carbamazepine; Cell Proliferation; Ethosuximide; Gingiva; Humans; Netherlands; Oral Hygiene; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 2018 |
Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Cost-Benefit Analysis; Decision Support Techniques; Humans; Lacosamide; Levetiracetam; Phenobarbital; Phenytoin; Status Epilepticus; Treatment Failure; Valproic Acid | 2019 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2020 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 2021 |
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Phenobarbital; Practice Guidelines as Topic; Pyrrolidinones; Spain; Triazoles; Valproic Acid | 2021 |
Movement disorders associated with antiseizure medications: A systematic review.
Topics: Anticonvulsants; Humans; Lacosamide; Movement Disorders; Phenobarbital; Valproic Acid | 2022 |
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Thyroid Hormones; Thyrotropin; Topiramate; Valproic Acid | 2022 |
COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed.
Topics: Anticonvulsants; Carbamazepine; Clobazam; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Humans; Oxcarbazepine; Pentobarbital; Phenobarbital; Phenytoin; Ritonavir; Valproic Acid | 2022 |
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Everolimus; Felbamate; Female; Fenfluramine; Gabapentin; Humans; Infant; Lacosamide; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenobarbital; Phenytoin; Prospective Studies; Tiagabine; Topiramate; Valproic Acid; Vigabatrin; Zonisamide | 2022 |
Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Drug Resistance; Humans; Levetiracetam; Network Meta-Analysis; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Status Epilepticus; Treatment Outcome; Valproic Acid | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; Levetiracetam; Lidocaine; Phenobarbital; Phenytoin; Propofol; Seizures; Status Epilepticus; Topiramate; Valproic Acid | 2022 |
54 trial(s) available for valproic acid and phenobarbital
| Article | Year |
|---|---|
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Female; Humans; Hydrocephalus; Infant; Male; Middle Aged; Phenobarbital; Phenytoin; Spasms, Infantile; Valerates; Valproic Acid | 1977 |
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Placebos; Valerates; Valproic Acid | 1977 |
[Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome].
Topics: Benzodiazepines; Child; Child, Preschool; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Valerates; Valproic Acid | 1978 |
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relationship, Drug; Drug Evaluation; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid | 1979 |
Has sodium valproate hypnotic effects?
Topics: Adult; Electroencephalography; Humans; Hypnotics and Sedatives; Male; Phenobarbital; Sleep; Time Factors; Valerates; Valproic Acid | 1976 |
Controlled trial of sodium valproate in severe epilepsy.
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Placebos; Valerates; Valproic Acid | 1975 |
[Phosphorus-calcium metabolism in children under prolonged treatment with anticonvulsants. (II)].
Topics: Anticonvulsants; Calcium; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Phenobarbital; Phosphorus; Valproic Acid | 1991 |
A pilot study of stiripentol, a new anticonvulsant drug, in complex partial seizures uncontrolled by carbamazepine.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dioxolanes; Dioxoles; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Phenobarbital; Pilot Projects; Valproic Acid | 1989 |
Intention to treat febrile convulsions with rectal diazepam, valproate or phenobarbitone.
Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Phenobarbital; Risk Factors; Seizures, Febrile; Valproic Acid | 1989 |
Psychologic and behavioral effects of antiepileptic drugs in children: a double-blind comparison between phenobarbital and valproic acid.
Topics: Adolescent; Anticonvulsants; Behavior; Child; Clinical Trials as Topic; Cognition; Double-Blind Method; Female; Humans; Male; Phenobarbital; Random Allocation; Valproic Acid | 1987 |
Randomised controlled trials of phenobarbitone and valproate in febrile convulsions.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Phenobarbital; Random Allocation; Recurrence; Seizures, Febrile; Valproic Acid | 1988 |
Prevention of recurrent febrile convulsions--a randomized therapeutic assay: sodium valproate, phenobarbital and placebo.
Topics: Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Drug; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Male; Phenobarbital; Placebos; Random Allocation; Recurrence; Seizures, Febrile; Valproic Acid | 1984 |
Controlled and comparative trials of valproate performed in Europe and Asia.
Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; Phenobarbital; Phenytoin; Seizures, Febrile; Valproic Acid | 1984 |
Phenobarbital--valporic acid interaction.
Topics: Adult; Drug Interactions; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Kinetics; Male; Phenobarbital; Valproic Acid | 1980 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant; Male; Phenobarbital; Random Allocation; Recurrence; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
[Efficacy of sodium dipropylacetate compared with phenobarbital and placebo in the prevention of recurrence of febrile convulsions].
Topics: Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Male; Phenobarbital; Placebos; Recurrence; Seizures, Febrile; Valproic Acid | 1982 |
Comparative cognitive effects of phenobarbital, phenytoin, and valproate in healthy adults.
Topics: Adult; Cognition; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Phenobarbital; Phenytoin; Reference Values; Valproic Acid | 1995 |
A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study.
Topics: Adult; Affect; Analysis of Variance; Epilepsy; Humans; Male; Neuropsychological Tests; Phenobarbital; Polysomnography; Psychomotor Performance; Reaction Time; Sleep; Surveys and Questionnaires; Time Factors; Valproic Acid | 1993 |
Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Valproic Acid | 1995 |
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Prospective Studies; Valproic Acid | 1995 |
Inhibition of phenobarbitone N-glucosidation by valproate.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Linear Models; Male; Middle Aged; Phenobarbital; Valproic Acid | 1994 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Epilepsy, Complex Partial; Female; Humans; Italy; Male; Middle Aged; Phenobarbital; Placebos; Seizures; Valproic Acid; Vigabatrin | 1994 |
Pharmacokinetic interaction between valproic acid and phenobarbital.
Topics: Administration, Oral; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Valproic Acid | 1993 |
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo.
Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid | 1993 |
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoassay; Humans; Immunoassay; Male; Phenobarbital; Phenytoin; Regression Analysis; Reproducibility of Results; Valproic Acid | 1995 |
Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Glutathione; Hemoglobins; Humans; Male; Middle Aged; Phenobarbital; Valproic Acid | 1995 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Prospective Studies; Treatment Outcome; Valproic Acid | 1996 |
Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study.
Topics: Adolescent; Anticonvulsants; Bender-Gestalt Test; Carbamazepine; Child; Cognition; Epilepsy; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Humans; Male; Phenobarbital; Valproic Acid; Wechsler Scales | 1996 |
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle Aged; Phenobarbital; Phenytoin; Psychiatric Status Rating Scales; Psychological Tests; Sleep Stages; Valproic Acid; Wakefulness | 1996 |
Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Lamotrigine; Male; Phenobarbital; Treatment Outcome; Triazines; Valproic Acid | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System Diseases; Neurologic Examination; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Primidone; Valproic Acid | 1996 |
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrigine; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Triazines; Valproic Acid | 1996 |
Comparison of phenobarbitone, phenytoin with sodium valproate: randomized, double-blind study.
Topics: Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Humans; Phenobarbital; Phenytoin; Recurrence; Valproic Acid | 1996 |
Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsies, Partial; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurologic Examination; Phenobarbital; Phenytoin; Primidone; Quality of Life; Valproic Acid | 1998 |
A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal.
Topics: Adult; Affect; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hostility; Humans; Male; Middle Aged; Neurologic Examination; Phenobarbital; Pilot Projects; Treatment Outcome; Valproic Acid | 1998 |
Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital.
Topics: Adolescent; Animals; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Statistics, Nonparametric; Valproic Acid | 1998 |
Prevention of febrile convulsions with dipropylacetate (Depakine).
Topics: Anticonvulsants; Child, Preschool; Humans; Phenobarbital; Primidone; Seizures, Febrile; Valproic Acid | 1975 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone; Proportional Hazards Models; Recurrence; Risk Assessment; Seizures; Substance Withdrawal Syndrome; Valproic Acid | 1999 |
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Epilepsies, Partial; Felbamate; Female; Humans; Lamotrigine; Male; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Prospective Studies; Triazines; Valproic Acid | 1999 |
A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dizziness; Drug Administration Schedule; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Headache; Humans; Male; Middle Aged; Phenobarbital; Sleep Stages; Survival Analysis; Treatment Outcome; Valproic Acid | 2000 |
Epilepsy and antiepileptic drug therapy in juvenile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbidity; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Female; Finland; Follow-Up Studies; Humans; Lamotrigine; Male; Neuronal Ceroid-Lipofuscinoses; Phenobarbital; Treatment Outcome; Triazines; Valproic Acid | 2000 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Primidone; Valproic Acid | 2002 |
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Lamotrigine; Male; Phenobarbital; Phenytoin; Prospective Studies; Topiramate; Triazines; Valproic Acid | 2002 |
The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Male; Oxcarbazepine; Phenobarbital; Valproic Acid | 1993 |
Factors associated with poor control in partial complex epilepsy.
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy, Complex Partial; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Phenobarbital; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Factors; Treatment Outcome; Triazines; Valproic Acid | 2004 |
Evolution of serum lipids and lipoprotein (a) levels in epileptic children treated with carbamazepine, valproic acid, and phenobarbital.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Diet; Epilepsy; Female; Humans; Lipids; Lipoprotein(a); Male; Phenobarbital; Time Factors; Valproic Acid | 2006 |
Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Apolipoproteins; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Infant; Lipids; Liver; Phenobarbital; Prospective Studies; Risk Factors; Time Factors; Transferases; Valproic Acid | 2006 |
Effective prophylactic therapy for cyclic vomiting syndrome in children using valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Dehydration; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Female; GABA Modulators; Humans; Male; Migraine Disorders; Phenobarbital; Recurrence; Syndrome; Treatment Outcome; Valproic Acid; Vomiting | 2009 |
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Phenobarbital; Seizures; Status Epilepticus; Treatment Outcome; Valproic Acid | 2012 |
Brivaracetam in Unverricht-Lundborg disease (EPM1): Results from two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fructose; Humans; Isoxazoles; Levetiracetam; Male; Middle Aged; Phenobarbital; Piracetam; Pyrrolidinones; Topiramate; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Young Adult; Zonisamide | 2016 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Prospective Studies; Status Epilepticus; Treatment Outcome; Valproic Acid | 2016 |
Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.
Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Models, Biological; Nonlinear Dynamics; Phenobarbital; Pyrrolidinones; Valproic Acid | 2017 |
Phenobarbital versus valproate for generalized convulsive status epilepticus in adults (2): A multicenter prospective randomized controlled trial in China (China 2-P vs. V).
Topics: Adult; Anticonvulsants; China; Humans; Phenobarbital; Prospective Studies; Status Epilepticus; Valproic Acid | 2021 |
Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial.
Topics: Adult; Anticonvulsants; Diazepam; Follow-Up Studies; Humans; Phenobarbital; Status Epilepticus; Treatment Outcome; Valproic Acid | 2023 |
619 other study(ies) available for valproic acid and phenobarbital
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of enaminones.
Topics: Amines; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electric Stimulation; Kindling, Neurologic; Male; Mice; Rats; Seizures; Structure-Activity Relationship | 1992 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; Imidazoles; Mice; Mice, Inbred ICR; Molecular Structure; Pyridines; Rats; Receptors, GABA-A; Seizures | 1991 |
Preparation and anticonvulsant activity of a series of functionalized alpha-heteroatom-substituted amino acids.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Molecular Structure; Nitrogen; Oxygen; Seizures; Structure-Activity Relationship; Sulfur | 1991 |
Synthesis and anticonvulsant activity of imidooxy derivatives.
Topics: Animals; Anticonvulsants; Chickens; Electroshock; Imides; Indicators and Reagents; Molecular Structure; Phthalimides; Reflex; Structure-Activity Relationship; Succinimides | 1991 |
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Gerbillinae; Hippocampus; Hypoxia; Male; Mice; Neurons; Phencyclidine; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Triazoles | 1990 |
Preparation and anticonvulsant activity of a series of functionalized alpha-aromatic and alpha-heteroaromatic amino acids.
Topics: Amino Acids; Animals; Anticonvulsants; Male; Mice; Structure-Activity Relationship | 1990 |
Synthesis and anticonvulsant activity of 2-benzylglutarimides.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Mice; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1990 |
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; gamma-Aminobutyric Acid; Isoniazid; Lactams; Liver; Male; Microsomes; Microsomes, Liver; Mitochondria; Mitochondria, Liver; Molecular Structure; Monoamine Oxidase; Oxidation-Reduction; Prodrugs; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1989 |
Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Topics: Animals; Anticonvulsants; Electroshock; Mice; Seizures; Structure-Activity Relationship; Triazoles | 1988 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures | 1986 |
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizures; Stereoisomerism; Structure-Activity Relationship | 1987 |
Anticonvulsant activity of some 4-aminobenzanilides.
Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1985 |
Synthesis and anticonvulsant activities of alpha-acetamido-N-benzylacetamide derivatives containing an electron-deficient alpha-heteroaromatic substituent.
Topics: Acetamides; Animals; Anticonvulsants; Male; Mice; Structure-Activity Relationship | 1994 |
Synthesis and anticonvulsant activities of alpha-heterocyclic alpha-acetamido-N-benzylacetamide derivatives.
Topics: Acetamides; Animals; Anticonvulsants; Benzeneacetamides; Benzyl Compounds; Furans; Heterocyclic Compounds; Male; Mice; Mice, Inbred Strains; Seizures; Stereoisomerism; Structure-Activity Relationship | 1993 |
Synthesis and CLOGP correlation of imidooxy anticonvulsants.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Electroshock; Male; Mice; Models, Molecular; Molecular Structure; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Seizures; Spiro Compounds; Structure-Activity Relationship | 1993 |
3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Humans; Magnetic Resonance Spectroscopy; Mice; Neurons; Pyrrolidinones | 1996 |
Synthesis and anticonvulsant activities of N-Benzyl-2-acetamidopropionamide derivatives.
Topics: Acetamides; Animals; Anticonvulsants; Benzylamines; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1996 |
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NADPH-Ferrihemoprotein Reductase; Organ Size; Oxidoreductases, O-Demethylating; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 1996 |
Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Caprolactam; Electrophysiology; Ethosuximide; Mice; Phenobarbital; Piperidones; Rats; Valproic Acid | 1997 |
Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.
Topics: Animals; Anticonvulsants; Electric Stimulation; Injections, Intraperitoneal; Male; Mice; Oxazoles; Rats; Seizures; Thiazoles | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Aza Compounds; Crystallography, X-Ray; Electroshock; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Rats; Seizures; Semicarbazides; Structure-Activity Relationship | 2001 |
Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
Topics: Affinity Labels; Amino Acids; Animals; Anticonvulsants; Electroshock; Isothiocyanates; Mice; Radioligand Assay; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizures; Structure-Activity Relationship | 2005 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver Injury; Drug Design; Female; gamma-Aminobutyric Acid; Male; Mice; Models, Molecular; Motor Activity; Rats; Seizures; Semicarbazones; Structure-Activity Relationship | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Activity; Rats; Seizures; Semicarbazides; Structure-Activity Relationship; Superoxide Dismutase | 2009 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Topics: Acetamides; Animals; Anticonvulsants; Electroshock; Hydrophobic and Hydrophilic Interactions; Lacosamide; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mice; Neuralgia; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Hydrazines; Male; Mice; Motor Activity; Rotarod Performance Test; Seizures | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents.
Topics: Ammonium Compounds; Animals; Anticonvulsants; Biphenyl Compounds; Male; Methylamines; Mice; Rats; Rats, Sprague-Dawley; Sodium Channels | 2013 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; Piperazine; Piperazines; Seizures | 2015 |
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Topics: Acetamides; Administration, Oral; Amides; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Electroshock; HEK293 Cells; Humans; Injections, Intraperitoneal; Male; Mice; Neurons; Patch-Clamp Techniques; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiazines | 2015 |
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Seizures; Structure-Activity Relationship | 2016 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone; Prognosis; Succinimides; Thiazines; Valproic Acid | 1975 |
[Drug interactions in antiepileptic combination therapy].
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Humans; Phenobarbital; Phenylbutyrates; Phenytoin; Primidone; Thiazines; Time Factors; Urea; Valproic Acid | 1979 |
Use of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1979 |
Urinary excretion of indican in progressive myoclonus epilepsy without Lafora bodies. The effect of sodium valproate.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsies, Myoclonic; Humans; Indican; Phenobarbital; Valproic Acid | 1978 |
[Pharmacological influence of valproate on phenobarbitone and phenytoin serum concentrations in epileptic patients (author's transl)].
Topics: Drug Interactions; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1979 |
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Nitrazepam; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1977 |
Management of childhood epilepsy.
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
Implications of measuring anticonvulsant blood levels in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
A study of the action of valproic acid on the kindling effect.
Topics: Amygdala; Animals; Cats; Electric Stimulation; Male; Phenobarbital; Seizures; Valerates; Valproic Acid | 1977 |
[Study of the immunosuppressive effect of some anticonvulsants in children].
Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immunity, Cellular; Immunoglobulins; Immunologic Techniques; Infant; Lymphocyte Activation; Male; Phenobarbital; Seizures; T-Lymphocytes; Valproic Acid | 1977 |
Preliminary observations on valproic acid kinetics in patients with epilepsy.
Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic Acid | 1977 |
Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations.
Topics: Acetazolamide; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nitrazepam; Olfactory Bulb; Phenobarbital; Phenylacetates; Phenytoin; Trimethadione; Urea; Valproic Acid | 1977 |
Epilepsy and IgA deficiency--the effect of sodium valproate.
Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobarbital; Phenytoin; Valerates; Valproic Acid | 1977 |
A comparative study of the efficacy of newer antiepiletpic drugs on experimentally-induced febrile convulsions.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamazepine; Clonazepam; Male; Mice; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1977 |
Choice of drug therapy in epilepsy.
Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Nitrazepam; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1978 |
Effect of anticonvulsants on thalamic afterdischarge in rats and cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Male; Phenobarbital; Phenytoin; Rats; Thalamus; Trimethadione; Valproic Acid | 1977 |
Effect of dipropylacetate on serum levels on anticonvulsants in children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Humans; Phenobarbital; Valproic Acid | 1978 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Primidone; Time Factors; Valproic Acid | 1978 |
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid | 1978 |
[Simultaneous estimation of phenobarbitone and valproic acid in the plasma by high performance liquid chromatography (author's transl)].
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Humans; Phenobarbital; Seizures; Valproic Acid | 1978 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Status Epilepticus; Valproic Acid | 1979 |
Effect of anticonvulsants on spiking activity induced by cortical freezing in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Arousal; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Freezing; Gallamine Triethiodide; Immobilization; Male; Phenobarbital; Phenytoin; Taurine; Trimethadione; Valproic Acid; Visual Cortex | 1979 |
Valproic acid binding to human serum albumin and determination of free fraction in the presence of anticonvulsants and free fatty acids.
Topics: Anticonvulsants; Carbamazepine; Fatty Acids, Nonesterified; Humans; Linoleic Acids; Oleic Acids; Palmitic Acids; Phenobarbital; Phenytoin; Protein Binding; Serum Albumin; Stearic Acids; Valproic Acid | 1979 |
Recent advances in drug therapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1979 |
The use of antiepileptic drugs.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sleep Stages; Sleep Wake Disorders; Valproic Acid | 1979 |
Anticonvulsant therapy in childhood. Recent advances.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1979 |
[The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)].
Topics: Antacids; Anticonvulsants; Biological Availability; Carbamazepine; Chromatography, Gas; Clonazepam; Dosage Forms; Ethosuximide; Half-Life; Humans; Immunoenzyme Techniques; Intestinal Absorption; Phenobarbital; Phenytoin; Primidone; Seizures; Valproic Acid | 1979 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epilepsies, Partial; Female; Heart; Male; Phenobarbital; Phenytoin; Seizures; Trimethadione; Valproic Acid | 1977 |
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)].
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Phenobarbital; Primidone; Valerates; Valproic Acid | 1977 |
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1975 |
[Myoclonic cerebellar dyssynergia with epilepsy (Ramsey-Hunt syndrome). Electro-clinical study in a patient of the black race].
Topics: Adult; Black People; Cerebellar Ataxia; Electroencephalography; Epilepsy; Female; Humans; Phenobarbital; Sodium; Valproic Acid | 1975 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
[Reflections on temporal epilepsy in the child].
Topics: Adolescent; Anticonvulsants; Epilepsy, Temporal Lobe; Humans; Male; Phenobarbital; Phenytoin; Social Behavior Disorders; Valproic Acid | 1976 |
Pharmacokinetics of di-n-propylacetate in epileptic patients.
Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Models, Biological; Parkinson Disease; Phenobarbital; Valerates; Valproic Acid | 1975 |
Proposals on antiepileptic pharmacotherapy for use in developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam; Epilepsy; Ethosuximide; Humans; Infant; Phenobarbital; Phenytoin; Valproic Acid | 1976 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Humans; Male; Nausea; Phenobarbital; Phenytoin; Valerates; Valproic Acid; Vomiting | 1976 |
Effect of the antiepileptic drug sodium valproate on induction of hepatic microsomal P450.
Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Phenobarbital; Potassium Chloride; Rats; Valerates; Valproic Acid | 1975 |
Regional distribution in brain and effect on cerebral mitochondrial respiration of the anticonvulsive drug n-dipropylacetate.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mitochondria; Oxygen Consumption; Phenobarbital; Valerates; Valproic Acid | 1975 |
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Valerates; Valproic Acid | 1975 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Ethosuximide; Injections, Intraperitoneal; Male; Pentylenetetrazole; Phenobarbital; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 1992 |
Pharmacokinetic interaction of zonisamide in rats. Effect of other antiepileptics on zonisamide.
Topics: Administration, Oral; Animals; Anticonvulsants; Blood Proteins; Diethylcarbamazine; Drug Interactions; Erythrocytes; Half-Life; Isoxazoles; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid; Zonisamide | 1992 |
[Multiple system atrophy with macro square wave jerks and pendular nystagmus].
Topics: Atrophy; Baclofen; Brain Diseases; Diazepam; Electrooculography; Eye Movements; Female; Humans; Middle Aged; Nystagmus, Pathologic; Phenobarbital; Saccades; Valproic Acid | 1992 |
Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.
Topics: Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Hippocampus; Kinetics; Neurons; Nicardipine; Phenobarbital; Phenytoin; Pyramidal Tracts; Rats; Rats, Wistar; Sodium; Tetrodotoxin; Valproic Acid; Verapamil | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Diltiazem; Drug Synergism; Flunarizine; Mice; Mice, Inbred DBA; Nimodipine; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Verapamil | 1992 |
Sixth-month benign familial convulsions.
Topics: Electroencephalography; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Infant; Male; Phenobarbital; Phenotype; Seizures, Febrile; Spasms, Infantile; Valproic Acid | 1992 |
Ring 14 chromosome with complex partial seizures: a case report.
Topics: Child; Chromosomes, Human, Pair 14; Electroencephalography; Epilepsy, Complex Partial; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Ring Chromosomes; Tomography, X-Ray Computed; Valproic Acid | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy; Female; Hemangioma, Cavernous; Humans; Magnetic Resonance Imaging; Male; Phenobarbital; Phenytoin; Retrospective Studies; Seizures; Valproic Acid | 1992 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Middle Aged; Neuropsychological Tests; Phenobarbital; Phenytoin; Psychomotor Performance; Valproic Acid | 1992 |
The effect of valproate on the metabolism of phenobarbital in the rat.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; In Vitro Techniques; Liver; Male; Phenobarbital; Protein Binding; Rats; Rats, Sprague-Dawley; Valproic Acid | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonazepam; Disease Susceptibility; Electroencephalography; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Organ Specificity; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1992 |
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phenobarbital; Phenytoin; Retrospective Studies; Valproic Acid | 1992 |
Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma.
Topics: Carbamazepine; Chromatography, Liquid; Clonazepam; Humans; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Least-Squares Analysis; Mefenamic Acid; Phenobarbital; Phenytoin; Salicylates; Salicylic Acid; Sensitivity and Specificity; Valproic Acid | 1992 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, Newborn; Neural Tube Defects; Phenobarbital; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
Antiepileptic drug disposition during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Valproic Acid | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Female; Fetus; Gestational Age; Head; Humans; Hydantoins; Infant; Infant, Newborn; Phenobarbital; Pregnancy; Pregnancy Complications; Primidone; Syndrome; Valproic Acid | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds Ratio; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Prospective Studies; Valproic Acid | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
Effects of long-term anticonvulsant therapy on copper, zinc, and magnesium in hair and serum of epileptics.
Topics: Adult; Anticonvulsants; Carbamazepine; Copper; Drug Therapy, Combination; Epilepsy, Generalized; Female; Hair; Humans; Long-Term Care; Magnesium; Male; Middle Aged; Phenobarbital; Phenytoin; Schizophrenia; Valproic Acid; Zinc | 1992 |
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus].
Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarbital; Phenytoin; Regional Blood Flow; Status Epilepticus; Valproic Acid; Zonisamide | 1992 |
Influence of antiepileptic drugs on sleep patterns.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Long-Term Care; Male; Phenobarbital; Phenytoin; Retrospective Studies; Sleep Deprivation; Sleep Stages; Valproic Acid | 1991 |
Balance and cognitive impairment in two epileptic patients before and after vagal nerve stimulation.
Topics: Adult; Carbamazepine; Cognition; Electric Stimulation Therapy; Epilepsy, Temporal Lobe; Humans; Male; Parkinson Disease; Phenobarbital; Phenytoin; Postural Balance; Reaction Time; Time Factors; Vagus Nerve; Valproic Acid | 1991 |
Performance of fluorescence polarisation immunoassay reagents for carbamazepine, phenytoin, phenobarbitone, primidone, and valproic acid on a Cobas Fara II analyser.
Topics: Anticonvulsants; Carbamazepine; Evaluation Studies as Topic; Fluorescence Polarization Immunoassay; Humans; Phenobarbital; Phenytoin; Primidone; Reference Standards; Valproic Acid | 1991 |
Clinical evaluation of five therapeutic drugs using dry film multilayer technology on the OPUS immunoassay system.
Topics: Carbamazepine; Evaluation Studies as Topic; Humans; Immunoassay; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Reference Standards; Sensitivity and Specificity; Theophylline; Valproic Acid | 1991 |
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Influence of MK-801 on the anticonvulsant activity of antiepileptics.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Electroshock; Learning; Male; Mice; Motor Activity; Phenobarbital; Seizures; Valproic Acid | 1991 |
[Suspected convulsive side-effect of mefloquine (Lariam)].
Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Humans; Malaria; Mefloquine; Phenobarbital; Valproic Acid | 1991 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Hemodynamics; Infusions, Parenteral; Male; Midazolam; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Liver damage in long-term anticonvulsant therapy: a serological and histological study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Isoantigens; Liver; Liver Diseases; Male; Middle Aged; Phenobarbital; Phenytoin; Retrospective Studies; Valproic Acid | 1991 |
Plasma uric acid in patients receiving anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prospective Studies; Uric Acid; Valproic Acid | 1991 |
Short-term effects of administration of anticonvulsant drugs on free carnitine and acylcarnitine in mouse serum and tissues.
Topics: Animals; Anticonvulsants; Carbamazepine; Carnitine; Heart; In Vitro Techniques; Male; Mice; Muscles; Myocardium; Phenobarbital; Phenytoin; Prohibitins; Valproic Acid | 1991 |
Alteration of renal carnitine metabolism by anticonvulsant treatment.
Topics: Ammonia; Animals; Anticonvulsants; Carbamazepine; Carnitine; Male; Mice; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Fetal Development; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Labor, Obstetric; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Spinal Dysraphism; Valproic Acid | 1991 |
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1991 |
Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children.
Topics: Analysis of Variance; Carbamazepine; Carnitine; Child; Drug Combinations; Fatty Acids; Fatty Acids, Volatile; Humans; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1991 |
Epileptic patients refractory to drug therapy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Effect of selective bilateral destruction of the substantia nigra on antiepileptic drug actions in kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Diazepam; Electrodes; Female; gamma-Aminobutyric Acid; Ibotenic Acid; Kindling, Neurologic; Phenobarbital; Rats; Rats, Inbred Strains; Substantia Nigra; Synaptic Transmission; Valproic Acid | 1990 |
Seizures: introduction and commentary.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Kindling from stimulation of a highly sensitive locus in the posterior part of the piriform cortex. Comparison with amygdala kindling and effects of antiepileptic drugs.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Diazepam; Electric Stimulation; Electrodes, Implanted; Female; Kindling, Neurologic; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1991 |
Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital.
Topics: Adolescent; Adult; Analysis of Variance; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Child; Child, Preschool; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Epilepsy; Female; Humans; Lipids; Male; Middle Aged; Phenobarbital; Valproic Acid | 1991 |
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Epilepsy, myasthenia gravis, and effect of plasmapheresis on antiepileptic drug concentrations.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Fluoroimmunoassay; Humans; Myasthenia Gravis; Phenobarbital; Plasmapheresis; Protein Binding; Valproic Acid | 1990 |
Paroxysmal nocturnal dystonia presenting as excessive daytime somnolence.
Topics: Adult; Carbamazepine; Diagnosis, Differential; Dystonia; Electroencephalography; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Phenobarbital; Sleep Stages; Sleep Wake Disorders; Trifluoperazine; Valproic Acid | 1990 |
[Clinical use of pharmacologic monitoring at a hospital community].
Topics: Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Utilization; Humans; Phenobarbital; Phenytoin; Product Surveillance, Postmarketing; Spain; Theophylline; Valproic Acid | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
The inhibitory effect of anticonvulsants on human sperm motility: measured with a trans-membrane migration method.
Topics: Adult; Anticonvulsants; Carbamazepine; Cell Membrane; Depression, Chemical; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sperm Motility; Valproic Acid | 1990 |
Simultaneous determination of six antiepileptic drugs by capillary gas chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Ethosuximide; Humans; Hydroxides; Phenobarbital; Phenytoin; Potassium; Potassium Compounds; Primidone; Valproic Acid | 1990 |
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Phenobarbital; Risk Factors; Valproic Acid; Wechsler Scales | 1990 |
Rapid anti-epileptic drug assay.
Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Patient Compliance; Phenobarbital; Phenytoin; Valproic Acid | 1990 |
Selective response to carbamazepine in a case of organic mood disorder.
Topics: Aged; Carbamazepine; Depressive Disorder; Female; Humans; Neurocognitive Disorders; Phenobarbital; Phenytoin; Valproic Acid | 1990 |
[Computerized analysis of EEG background activity in mono-therapeutic patients with epilepsy--relationships between antiepileptic drugs and types of seizures].
Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Phenobarbital; Valproic Acid | 1990 |
Sensorineural hearing loss: a reversible effect of valproic acid.
Topics: Aged; Audiometry; Epilepsy, Temporal Lobe; Hearing Loss, Sensorineural; Humans; Male; Phenobarbital; Phenytoin; Remission, Spontaneous; Valproic Acid | 1990 |
Development of monoclonal antibodies for therapeutic drug monitoring.
Topics: Antibodies, Monoclonal; Anticonvulsants; Carbamazepine; Cross Reactions; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximide; Male; Mice; Nifedipine; Pentylenetetrazole; Phenobarbital; Reference Values; Seizures; Valproic Acid; Verapamil | 1990 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clobazam; Drug Therapy, Combination; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin; Time Factors; Valproic Acid | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1990 |
Comparative experimental study of antiepileptics--regional specificity of antiepileptic action of carbamazepine, phenobarbital and valproate sodium.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Male; Motor Cortex; Phenobarbital; Rabbits; Valproic Acid; Visual Cortex | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--carbamazepine.
Topics: Aging; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Phenobarbital; Phenytoin; Regression Analysis; Retrospective Studies; Valproic Acid | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid.
Topics: Adolescent; Adult; Aging; Aspartate Aminotransferases; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Regression Analysis; Retrospective Studies; Sex Factors; Valproic Acid | 1990 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepam; Electroshock; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials; Mice; Neurons; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1985 |
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarbital; Phenytoin; Valproic Acid | 1989 |
The prevalence of adverse reactions to anticonvulsants in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenobarbital; Valproic Acid | 1989 |
[Plasma determination of 7 common drugs by high performance liquid chromatography].
Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid | 1989 |
Carnitine deficiency associated with anticonvulsant therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1989 |
[Effects of anticonvulsants on cellular immunity].
Topics: Animals; Anticonvulsants; Cell Division; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Mice; Phenobarbital; Phenytoin; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Valproic Acid | 1989 |
Variations in protein binding of drugs in plasma and serum.
Topics: Anticonvulsants; Blood Proteins; Carbamazepine; Chromatography, High Pressure Liquid; Fluoroimmunoassay; Humans; Hydrogen-Ion Concentration; Phenobarbital; Phenytoin; Protein Binding; Theophylline; Valproic Acid | 1989 |
Effects of anticonvulsants on plasma levels and entero-hepatic circulation of valproic acid and on hepatic drug metabolizing enzyme activities in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Enterohepatic Circulation; Liver; Male; Phenobarbital; Phenytoin; Protein Binding; Rats; Rats, Inbred Strains; Valproic Acid | 1989 |
The effect of concurrent administration of sodium valproate on serum levels of primidone and its metabolite phenobarbital.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phenobarbital; Primidone; Retrospective Studies; Valproic Acid | 1989 |
Serum free levels and evaluation anticonvulsant drug interactions.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproic Acid | 1989 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primidone; Recurrence; Seizures; Spain; Valproic Acid | 1989 |
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Humans; Male; Neuropsychological Tests; Phenobarbital; Psychomotor Performance; Valproic Acid | 1989 |
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hippocampus; In Vitro Techniques; Ion Channels; Midazolam; Phenobarbital; Phenytoin; Rats; Valproic Acid | 1985 |
[Mechanism of action of antiepileptic drugs].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; gamma-Aminobutyric Acid; Ion Exchange; Phenobarbital; Phenytoin; Receptors, Neurotransmitter; Synaptic Transmission; Valproic Acid | 1987 |
Automated determination of drugs in serum by liquid chromatography with column-switching. I. Separation of antiepileptic drugs and metabolites.
Topics: Acetonitriles; Anticonvulsants; Blood Proteins; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Perchlorates; Phenobarbital; Phenytoin; Quality Control; Regression Analysis; Statistics as Topic; Trichloroacetic Acid; Valproic Acid | 1988 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Female; Mice; N-Methylaspartate; Phenobarbital; Seizures; Synaptic Transmission; Valproic Acid | 1987 |
Differential effects of anticonvulsants on developing neurons in vitro.
Topics: Animals; Anticonvulsants; Binding, Competitive; Carbamazepine; Cells, Cultured; Chick Embryo; Immunohistochemistry; Neurons; Phenobarbital; Phenytoin; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Valproic Acid | 1988 |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Electroencephalography; Ethosuximide; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1987 |
Effects of anticonvulsant drugs on brain cultures from chick embryos: a comparison with cultures from embryos treated in ovo.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain; Carbonic Anhydrases; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Kinetics; Neurons; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Male; Phenobarbital; Phenytoin; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Nursing interventions for anticonvulsant drug interactions.
Topics: Anticonvulsants; Biotransformation; Carbamazepine; Drug Interactions; Humans; Nursing Care; Patient Education as Topic; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1986 |
Valproate-associated hyperammonemia and DL-carnitine supplement.
Topics: Adolescent; Adult; Ammonia; Carbamazepine; Carnitine; Child; Child, Preschool; Disabled Persons; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1987 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
[The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of maximal electroshock seizures in mice].
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Humans; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1986 |
Therapeutic drug monitoring in patients with chronic renal failure: evaluation of the Abbott TDx drug assay system.
Topics: Carbamazepine; Cross Reactions; Digoxin; Gentamicins; Humans; Immunoassay; Kidney Failure, Chronic; Lidocaine; Monitoring, Physiologic; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Quinidine; Valproic Acid; Vancomycin | 1986 |
Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen.
Topics: Administration, Oral; Animals; Biotransformation; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Neural Tube Defects; Phenobarbital; Pregnancy; Teratogens; Valproic Acid | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Seizures; Sex Factors; Valproic Acid | 1986 |
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Valproic Acid | 1986 |
Modulation of the behavioral effects of anticonvulsant drugs by an external discriminative stimulus in the pigeon.
Topics: Animals; Anticonvulsants; Columbidae; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Phenobarbital; Phenytoin; Probability; Reinforcement Schedule; Valproic Acid | 1986 |
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultraviolet Rays; Valproic Acid; Vitamin D | 1986 |
[Treatment of epileptic patients with Jacksonian seizures].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Temporal Lobe; Humans; Nitrazepam; Phenobarbital; Valproic Acid | 1986 |
Benzodiazepine cross-tolerance in mice extends to sodium valproate.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam; Diazepam; Drug Tolerance; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Valproic Acid | 1986 |
Genetic differences in anticonvulsant sensitivity in mouse lines selectively bred for ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcohols; Animals; Anticonvulsants; Diazepam; Disease Susceptibility; Electroshock; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Psychoses, Alcoholic; Valproic Acid | 1986 |
Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Ethosuximide; Male; Neurons; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Substantia Nigra; Trimethadione; Valproic Acid | 1986 |
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epilepsy; Male; Phenobarbital; Phenytoin; Piracetam; Pyrrolidines; Pyrrolidinones; Rats; Valproic Acid | 1986 |
Lack of hepatotoxic interaction between the anticonvulsant drugs phenytoin, sodium valproate and phenobarbital in the rat.
Topics: Administration, Oral; Animals; Drug Interactions; Enzyme Induction; Liver; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Valproic Acid | 1986 |
A sporadic case of benign myoclonus epilepsy of adult onset: its clinical aspects and electroencephalographic, polygraphic study.
Topics: Adult; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Phenobarbital; Photic Stimulation; Sleep; Valproic Acid | 1986 |
Effects of phenobarbital in combination with phenytoin or valproic acid on the delayed-matching-to-sample performance of pigeons.
Topics: Animals; Columbidae; Drug Interactions; Memory, Short-Term; Phenobarbital; Phenytoin; Valproic Acid | 1986 |
Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Carbamazepine; Diazepam; Female; Glutamates; Mice; Oxadiazoles; Phenobarbital; Phenytoin; Quisqualic Acid; Seizures; Valproic Acid | 1986 |
Effects of coadministered antiepileptic drugs on free fractions of phenobarbital and valproic acid in epileptic children.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Serum Albumin; Valproic Acid | 1986 |
Chronic valproic acid and coantiepileptic drug therapy and incidence of increases in serum liver enzymes.
Topics: Adolescent; Adult; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Child; Child, Preschool; Drug Interactions; Female; Humans; Infant; Liver; Male; Phenobarbital; Phenytoin; Valproic Acid | 1986 |
Effect of sodium valproate on phenobarbital serum levels in children and adults.
Topics: Adult; Age Factors; Child; Female; Humans; Kinetics; Male; Phenobarbital; Valproic Acid | 1986 |
[Modification of psychophysical performance of the human by anticonvulsants].
Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes; Phenobarbital; Psychological Tests; Psychomotor Performance; Valproic Acid | 1987 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Growth Retardation; France; Humans; Infant; Infant, Low Birth Weight; Infant, Newborn; Italy; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Sweden; Valproic Acid | 1987 |
Inhibition of aldehyde reductases.
Topics: Alcohol Dehydrogenase; Animals; Imidazoles; Imidazolidines; Kinetics; Phenobarbital; Valproic Acid | 1987 |
Low-dose phenobarbitone as an indicator of compliance with drug therapy.
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Male; Middle Aged; Patient Compliance; Phenobarbital; Valproic Acid; Warfarin | 1987 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; Humans; Memory Disorders; Phenobarbital; Phenytoin; Temporal Lobe; Valproic Acid | 1987 |
Anticonvulsant medication in a mental handicap hospital: 1972-1982.
Topics: Anticonvulsants; Carbamazepine; Female; Hospitals, Psychiatric; Humans; Intellectual Disability; Male; Phenobarbital; Phenytoin; Valproic Acid | 1987 |
Thyroid function in children with long-term anticonvulsant treatment.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; Humans; Infant; Male; Osmolar Concentration; Phenobarbital; Resins, Plant; Thyroid Gland; Thyrotropin; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Valproic Acid | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Delayed bone development in epileptic children assessed by microdensitometer.
Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Densitometry; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Radiography; Valproic Acid | 1988 |
Antiepileptic drugs and puberty.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Estradiol; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Phenobarbital; Puberty; Testosterone; Valproic Acid | 1988 |
Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
Topics: Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Fatty Acids, Monounsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Phenytoin; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Valproic Acid | 1988 |
Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Electroshock; Female; Mice; Mice, Inbred ICR; Neurotoxins; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 1988 |
The role of ultrasound in the early diagnosis of fetal structural defects following maternal anticonvulsant therapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Diazepam; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Middle Aged; Phenobarbital; Phenytoin; Pregnancy; Prenatal Diagnosis; Prospective Studies; Ultrasonography; Valproic Acid | 1988 |
Pharmacologic interactions between valproate and other drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1988 |
Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Carbamazepine; Child; Epilepsies, Partial; Evoked Potentials, Auditory; Female; gamma-Aminobutyric Acid; Humans; Long-Term Care; Male; Middle Aged; Phenobarbital; Reaction Time; Valproic Acid | 1988 |
[Prognosis of complicated febrile convulsions in therapy with primidone, cathine-phenobarbital and calcium valproinate].
Topics: Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Male; Phenobarbital; Phenylpropanolamine; Primidone; Prognosis; Seizures, Febrile; Valproic Acid | 1988 |
Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Enzyme Induction; Flavonoids; Glucuronates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Seizures; Time Factors; Valproic Acid | 1985 |
Drug interactions between antiepileptic drugs and other drugs.
Topics: Anticonvulsants; Drug Interactions; Humans; Kinetics; Phenobarbital; Valproic Acid | 1985 |
Effects of phenytoin, phenobarbital, and valproic acid, alone and in selected combinations, on schedule-controlled behavior of rats.
Topics: Animals; Conditioning, Operant; Drug Interactions; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Reinforcement Schedule; Time Factors; Valproic Acid | 1985 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Ethosuximide; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Trimethadione; Valproic Acid | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabolic Clearance Rate; Patient Compliance; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Valproic Acid | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
Concurrent determination of valproic acid with other antiepileptic drugs by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Effect of associated antiepileptic treatment on valproate-induced hyperammonemia.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Drug Interactions; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Time Factors; Valproic Acid | 1985 |
Monotherapy and polytherapy for intractable epilepsies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1985 |
Effects of phenobarbital, clonazepam, valproic acid, ethosuximide, and phenytoin on the delayed matching-to-sample performance of pigeons.
Topics: Animals; Anticonvulsants; Clonazepam; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethosuximide; Memory; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
Interictal EEG prediction of response to antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Prognosis; Sleep Deprivation; Valproic Acid | 1985 |
Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Ethosuximide; Female; Follow-Up Studies; Humans; Infant; Male; Middle Aged; Phenobarbital; Prognosis; Time Factors; Valproic Acid | 1985 |
American Academy of Pediatrics. Behavioral and cognitive effects of anticonvulsant therapy. Committee on Drugs.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Child; Child Behavior Disorders; Clonazepam; Cognition; Humans; Infant; Memory Disorders; Phenobarbital; Phenytoin; Psychological Tests; Valproic Acid | 1985 |
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
The optimum use of anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Protein Binding; Serum Albumin; Valproic Acid | 1985 |
Where, why, and what type of therapy.
Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Phenobarbital; Phenytoin; Recurrence; Risk; Succinimides; Valproic Acid | 1985 |
Monitoring: the most important role of the pediatrician.
Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitoring; Epilepsy; Ethosuximide; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin; Referral and Consultation; Social Support; Valproic Acid | 1985 |
Serum concentrations of valproic acid: influence of dose and comedication.
Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Valproic Acid | 1985 |
Seizure control following administration of anticonvulsant drugs in the quaking mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Mice; Mice, Inbred C57BL; Mice, Quaking; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1985 |
Use of total and free anticonvulsant serum levels in clinical practice.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
Phenytoin interacts with calcium channels in brain membranes.
Topics: Animals; Brain; Calcium; Carbamazepine; Clonazepam; In Vitro Techniques; Ion Channels; Male; Nifedipine; Nitrendipine; Phenobarbital; Phenytoin; Rats; Valproic Acid | 1984 |
Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Flunitrazepam; Male; Phenobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Valproic Acid | 1984 |
Diphenylhydantoin substrate induced difference spectra: inhibition by other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Ethosuximide; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Spectrophotometry; Thiazines; Valproic Acid | 1980 |
Fatal hepatotoxicity in child on phenobarbitone and sodium valproate.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy, Tonic-Clonic; Humans; Male; Phenobarbital; Valproic Acid | 1980 |
Psychiatric implications of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Mental Disorders; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1980 |
[Effects of drug interaction in infancy (author's transl)].
Topics: Carbamazepine; Child; Chloramphenicol; Clonazepam; Dexamethasone; Drug Interactions; Humans; Isoniazid; Metronidazole; Phenobarbital; Phenytoin; Sulfonamides; Valproic Acid | 1980 |
Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide, and sulthiame in the rat.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Ethosuximide; gamma-Aminobutyric Acid; Glutamates; Male; Neurotransmitter Agents; Organ Specificity; Phenobarbital; Phenytoin; Rats; Taurine; Thiazines; Valproic Acid | 1981 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Therapy, Combination; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Semicarbazides; Valproic Acid | 1981 |
[Cross tolerance when benzodiazepines are administered with other substances].
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Drug Interactions; Drug Tolerance; Ethanol; Inosine; Male; Mice; Muscimol; Niacinamide; Phenobarbital; Valproic Acid | 1981 |
Choice of anticonvulsants in epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Epilepsy; Ethosuximide; Follow-Up Studies; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1981 |
A water lick conflict paradigm using drug experienced rats.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Dose-Response Relationship, Drug; Male; Phenobarbital; Psychotropic Drugs; Punishment; Pyridazines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Valproic Acid; Water Deprivation | 1981 |
Effect of antiepileptic drugs on the cerebral amino acid uptake in vitro.
Topics: Absorption; Amino Acids; Animals; Anticonvulsants; Brain; Clonazepam; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Phenobarbital; Phenytoin; Valproic Acid | 1981 |
Enhancement of GABAergic inhibition: a mechanism of action of benzodiazepines, phenobarbital, valproate and L-cycloserine in the cat spinal cord.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cats; Cycloserine; GABA Antagonists; gamma-Aminobutyric Acid; Interneurons; Motor Neurons; Phenobarbital; Spinal Cord; Valproic Acid | 1982 |
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1982 |
[Rise in gamma-GT during anticonvulsive therapy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Liver; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1982 |
Metabolic interactions of phenytoin in the rat: effect of coadministration with the anticonvulsant drugs sodium valproate, sulthiame, ethosuximide or phenobarbital.
Topics: Animals; Anticonvulsants; Brain; Drug Interactions; Ethosuximide; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Thiazines; Valproic Acid | 1984 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Ethosuximide; Female; Half-Life; Humans; Infant; Infant, Newborn; Intestinal Absorption; Kinetics; Male; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Pregnancy; Primidone; Protein Binding; Valproic Acid | 1983 |
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorders; Phenobarbital; Phenytoin; Primidone; Valproic Acid; Vitamin B 12 | 1983 |
Plasma concentrations of valproate during maintenance therapy in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Female; Half-Life; Humans; Male; Phenobarbital; Phenytoin; Valproic Acid | 1982 |
Antiepileptic agents affect hypothalamic beta-endorphin concentrations.
Topics: Animals; Anticonvulsants; beta-Endorphin; Endorphins; Ethosuximide; Hypothalamus; Kinetics; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Somatostatin; Substance P; Valproic Acid | 1984 |
Effects of anticonvulsants on excitability and GABA sensitivity of cat dorsal root ganglion cells.
Topics: Action Potentials; Animals; Anticonvulsants; Cats; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Kinetics; Male; Phenobarbital; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1981 |
A monkey model for status epilepticus: carbamazepine and valproate compared to three standard anticonvulsants.
Topics: Aluminum Hydroxide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Macaca mulatta; Male; Phenobarbital; Phenytoin; Pyridoxine; Status Epilepticus; Valproic Acid | 1983 |
[Sodium valproate: a hyperammonemic drug. Study in the epileptic and healthy volunteer].
Topics: Ammonia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Feeding Behavior; Humans; Phenobarbital; Valproic Acid | 1983 |
The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Epilepsy; Humans; Lipoproteins, HDL; Phenobarbital; Stimulation, Chemical; Valproic Acid | 1983 |
Reduction of two-drug therapy in intractable epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Humans; Phenobarbital; Phenytoin; Prospective Studies; Valproic Acid | 1983 |
Febrile seizures in epileptic chicks: the effects of phenobarbital, phenytoin and valproate.
Topics: Animals; Chickens; Disease Models, Animal; Phenobarbital; Phenytoin; Reaction Time; Seizures, Febrile; Valproic Acid | 1983 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylphenidate; Phenobarbital; Phenytoin; Sleep; Status Epilepticus; Valproic Acid | 1983 |
Therapeutic monitoring of serum antiepileptic drug levels.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Humans; Laboratories; Monitoring, Physiologic; Phenobarbital; Phenytoin; Primidone; Time Factors; Valproic Acid | 1983 |
Diurnal fluctuations in free and total plasma concentrations of valproic acid at steady state in epileptic patients.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital; Time Factors; Valproic Acid | 1983 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbital; Pregnancy; Pregnancy Complications; Strabismus; Valproic Acid | 1983 |
Delayed effects of drug exposure during pregnancy: reproductive function.
Topics: Animals; Anticonvulsants; Estrus; Female; Fertility; Luteinizing Hormone; Male; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reproduction; Sexual Maturation; Testosterone; Valproic Acid | 1983 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Status Epilepticus; Valproic Acid | 1983 |
Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans.
Topics: Adult; Ammonia; Epilepsy; Female; Humans; Kidney; Liver; Male; Middle Aged; Phenobarbital; Valproic Acid | 1983 |
Treatment of the nonconvulsive epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1983 |
Antiepileptic drug therapy. Fine tuning the dosage regimen.
Topics: Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Interactions; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin; Valproic Acid | 1983 |
Febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Recurrence; Seizures; Valproic Acid | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Post-Traumatic; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Humans; Infant; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Seizures, Febrile; Status Epilepticus; Valproic Acid | 1983 |
[Absence status in the adult].
Topics: Adult; Electroencephalography; Epilepsy, Absence; Female; Humans; Male; Middle Aged; Pentobarbital; Phenobarbital; Valproic Acid | 1983 |
Valproate glucuronidation by rat liver microsomes. Interaction with parahydroxyphenobarbital.
Topics: Animals; Chromatography, Gas; Glucuronosyltransferase; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity; Valproic Acid | 1983 |
A new method for kinetic studies of drug interactions in experimental animals during steady state. Controlled-rate application of valproic acid, phenobarbital and their combinations via implanted osmotic minipumps in the mouse.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Implants; Drug Interactions; Female; Kinetics; Mice; Phenobarbital; Valproic Acid | 1983 |
The influence of anticonvulsants on fasting plasma ammonia and amino acid levels.
Topics: Amino Acids; Ammonia; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Glutamine; Glycine; Humans; Infant; Ornithine; Phenobarbital; Valproic Acid | 1983 |
Effectiveness and toxicity of phenobarbital, primidone, and sodium valproate in the prevention of febrile convulsions, controlled by plasma levels.
Topics: Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Male; Phenobarbital; Primidone; Seizures, Febrile; Valproic Acid | 1984 |
Effects of anticonvulsants on hyperthermia-induced seizures in the rat pup.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Differential Threshold; Disease Models, Animal; Electroencephalography; Phenobarbital; Phenytoin; Rats; Seizures, Febrile; Valproic Acid | 1984 |
[Determination of plasma levels of anticonvulsant drugs. Preliminary report of our experiences].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1983 |
Unnecessary polypharmacy in patients with frequent seizures.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1984 |
Anticonvulsant potency of common antiepileptic drugs in the gerbil.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Female; Gerbillinae; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1983 |
The place of saliva in antiepileptic drug monitoring.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Female; Humans; Middle Aged; Phenobarbital; Plasma; Primidone; Saliva; Valproic Acid | 1984 |
Microscale ultrafiltration technique for determining free drug in 50-microL serum samples.
Topics: Animals; Chloramphenicol; Diazepam; Furosemide; Humans; Indomethacin; Infant; Infant, Newborn; Microchemistry; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Ultrafiltration; Valproic Acid | 1984 |
Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Oxidoreductases; Phenobarbital; Phenytoin; Valproic Acid | 1984 |
Enzyme induction in neonates after fetal exposure to antiepileptic drugs.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Anticonvulsants; Breath Tests; Carbamazepine; Carbon Radioisotopes; Enzyme Induction; Female; Humans; Infant, Newborn; Liver; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Primidone; Valproic Acid | 1983 |
The effects of various antiepileptic drugs on E-shock-induced amnesia in mice: dissociability of effects on convulsions and effects on memory.
Topics: Amnesia; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Electroshock; Ethosuximide; Humans; Male; Mice; Phenobarbital; Phenytoin; Valproic Acid | 1984 |
Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenobarbital; Piracetam; Pyrrolidinones; Rats; Valproic Acid; Vinca Alkaloids; Vincamine | 1984 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Psychotropic Drugs; Valproic Acid | 1984 |
Effects of anticonvulsants on learning: performance of pigeons under a repeated acquisition procedure when exposed to phenobarbital, clonazepam, valproic acid, ethosuximide and phenytoin.
Topics: Animals; Anticonvulsants; Clonazepam; Columbidae; Dose-Response Relationship, Drug; Ethosuximide; Learning; Phenobarbital; Phenytoin; Valproic Acid | 1984 |
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Phenobarbital; Phenytoin; Postoperative Complications; Valproic Acid | 1984 |
Aspects of the metabolism of valproic acid.
Topics: Animals; Biotransformation; Drug Interactions; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Injections, Intraperitoneal; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1984 |
Metabolism of valproic acid by hepatic microsomal cytochrome P-450.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Valproic Acid | 1984 |
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Topics: Animals; Carnitine; Fasting; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Proadifen; Seizures; Valproic Acid | 1984 |
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-Life; Humans; Immunoenzyme Techniques; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1984 |
Pharmacologic therapy of seizures in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Status Epilepticus; Valproic Acid | 1984 |
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1984 |
One drug for childhood grand mal: medical audit for three-year remissions.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Glycine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1984 |
[Determination of theophylline, phenobarbital and valproic acid by chromatographic and immunologic technics. Comparison of methods].
Topics: Chromatography; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Immunoassay; Immunoenzyme Techniques; Phenobarbital; Theophylline; Valproic Acid | 1984 |
Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.
Topics: Child, Preschool; Female; Humans; Infant; Male; Phenobarbital; Recurrence; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
[Anticonvulsive combined therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Valproic acid.
Topics: Adult; Drug Therapy, Combination; Humans; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1980 |
Interactions of valproic acid with phenytoin.
Topics: Adult; Drug Interactions; Half-Life; Humans; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Valproic Acid | 1980 |
[On the potentiation of the effects of phenobarbital by dipropylacetic acid (author's transl)].
Topics: Drug Synergism; Female; Humans; Male; Middle Aged; Phenobarbital; Sodium; Valproic Acid | 1980 |
Phenobarbitone and sodium valproate interaction: an experimental study.
Topics: Animals; Anticonvulsants; Drug Interactions; Male; Mice; Phenobarbital; Valproic Acid | 1980 |
Prevention of simple febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions.
Topics: Humans; Infant; Infant, Newborn; Phenobarbital; Recurrence; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Hepatotoxicity of sodium valproate and other anticonvulsants in rat hepatocyte cultures.
Topics: Animals; Anticonvulsants; Clonazepam; Culture Techniques; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Liver; Phenobarbital; Phenytoin; Primidone; Rats; Valproic Acid | 1980 |
[Problems of therapeutic service in primidone therapy].
Topics: Adolescent; Drug Administration Schedule; Drug Interactions; Epilepsy, Tonic-Clonic; Female; Half-Life; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1980 |
Pharmacokinetics of anticonvulsant drugs.
Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epilepsy; Folic Acid; Humans; Kinetics; Phenobarbital; Phenytoin; Protein Binding; Tissue Distribution; Valproic Acid | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Seizures, Febrile; Valproic Acid | 1981 |
Febrile convulsions: long-term treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Humans; Infant; Phenobarbital; Prognosis; Recurrence; Seizures; Seizures, Febrile; Valproic Acid | 1981 |
Mechanism of valproate-phenobarbital interaction in epileptic patients.
Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital; Valproic Acid | 1981 |
Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels.
Topics: Adolescent; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
[Rickets in a child due to the combination of phenobarbital and valproic acid].
Topics: Drug Therapy, Combination; Female; Humans; Infant; Phenobarbital; Rickets; Valproic Acid | 1981 |
Valproic acid and plasma levels of primidone and derived phenobarbital.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Humans; Kinetics; Male; Phenobarbital; Primidone; Valproic Acid | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Primidone; Seizures; Substance Withdrawal Syndrome; Valproic Acid | 1981 |
Valproic acid fails to displace phenobarbitone and carbamazepine from plasma protein binding sites in epileptic patients.
Topics: Adolescent; Adult; Binding, Competitive; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital; Protein Binding; Valproic Acid | 1981 |
The effect of concurrent administration of valproate sodium on phenobarbital plasma concentration/dosage ratio in pediatric patients.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Retrospective Studies; Valproic Acid | 1981 |
[Effects of phenobarbital on the elimination of valproic acid].
Topics: Animals; Female; Phenobarbital; Rats; Time Factors; Valproic Acid | 1981 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Reduction of steady-state valproate levels by other antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1981 |
Inhibition of microsomal phenobarbital metabolism by valproic acid.
Topics: Animals; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Valproic Acid | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Valproic Acid | 1980 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Phenytoin; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1981 |
Sodium valproate versus phenobarbital in the prophylactic treatment of febrile convulsions in childhood.
Topics: Child Behavior Disorders; Child, Preschool; Female; Humans; Infant; Male; Phenobarbital; Seizures, Febrile; Valproic Acid | 1981 |
Phenobarbital, primidone and sodium valproate in the prophylaxis of febrile convulsions.
Topics: Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Phenobarbital; Primidone; Recurrence; Seizures, Febrile; Valproic Acid | 1981 |
A computer analysis of specific and aspecific interictal epileptic activity in man.
Topics: Computers; Electroencephalography; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
Some behavioral effects of antiepileptic drugs during acute and prolonged treatment in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Tolerance; Motor Skills; Phenobarbital; Phenytoin; Rats; Valproic Acid | 1981 |
Increased serum phospholipids in epileptic children treated with phenobarbitone.
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phospholipids; Valproic Acid | 1982 |
Febrile convulsions: intellectual progress in relation to anticonvulsant therapy and to recurrence of fits.
Topics: Child Development; Child, Preschool; Humans; Infant; Intelligence; Intelligence Tests; Phenobarbital; Recurrence; Seizures, Febrile; Valproic Acid | 1982 |
Effect of age on concurrent administration of phenobarbital and valproic acid.
Topics: Age Factors; Child; Child, Preschool; Drug Interactions; Humans; Infant; Phenobarbital; Valproic Acid | 1982 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Valproic Acid | 1982 |
Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ethosuximide; Guinea Pigs; Hippocampus; Kainic Acid; Phenobarbital; Phenytoin; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1982 |
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepam; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1982 |
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbital; Seizures, Febrile; Spinal Puncture; Valproic Acid | 1982 |
Effect of sodium valproate and ethosuximide on phenobarbital plasma protein binding.
Topics: Binding, Competitive; Blood Proteins; Ethosuximide; Humans; Phenobarbital; Valproic Acid | 1982 |
Placental transfer of anticonvulsants (phenobarbital, phenytoin, valproic acid) and the elimination from neonates.
Topics: Anticonvulsants; Bilirubin; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Valproic Acid | 1981 |
Brain maturation following administration of phenobarbital, phenytoin, and sodium valproate to developing rats or to their dams: effects on synthesis of brain myelin and other subcellular membrane proteins.
Topics: Animals; Anticonvulsants; Brain; Female; Intracellular Membranes; Membrane Proteins; Myelin Proteins; Organ Size; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Valproic Acid | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Postpartum Period; Pregnancy; Pregnancy Complications; Time Factors; Valproic Acid | 1982 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalography; Kinetics; Macaca mulatta; Male; Phenobarbital; Phenytoin; Primidone; Seizures; Valproic Acid | 1982 |
Two antiepileptic drugs for intractable epilepsy with complex-partial seizures.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Humans; Phenobarbital; Phenytoin; Primidone; Valproic Acid | 1982 |
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarbital; Reye Syndrome; Valproic Acid; Vomiting | 1982 |
Serum protein binding interaction between valproic acid and phenobarbital in vitro.
Topics: Adult; Binding Sites; Blood Proteins; Drug Interactions; Humans; In Vitro Techniques; Phenobarbital; Protein Binding; Valproic Acid | 1982 |
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbital; Phenytoin; Primidone; Saliva; Valproic Acid | 1982 |
Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Phenobarbital; Valproic Acid | 1980 |
Valproic acid and plasma levels of phenobarbital.
Topics: Adult; Animals; Cats; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Male; Phenobarbital; Valproic Acid | 1980 |
Measurement of sodium valproate in serum by direct-insertion chemical-ionization/mass spectrometry.
Topics: Carbamazepine; Humans; Mass Spectrometry; Microchemistry; Phenobarbital; Valproic Acid | 1980 |
Validation of a quick modeling program generating clearance estimates at steady state for routine therapeutic drug monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Monitoring; Humans; Metabolic Clearance Rate; Models, Biological; Phenobarbital; Software; Valproic Acid | 1995 |
Practical considerations in anticonvulsant therapy--Part 2.
Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiologic; Patient Compliance; Patient Education as Topic; Pharmacists; Phenobarbital; Phenytoin; Primidone; Role; Valproic Acid | 1995 |
Influence of BAY k-8644, a calcium channel agonist, on the anticonvulsant activity of conventional anti-epileptics against electroconvulsions in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Electroshock; Flunarizine; Male; Mice; Phenobarbital; Valproic Acid | 1995 |
Cytokine production in blood mononuclear cells from epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cytokines; Epilepsy; Female; Humans; Interleukin-1; Interleukin-2; Interleukin-6; Leukocytes, Mononuclear; Male; Middle Aged; Mitogens; Phenobarbital; Valproic Acid | 1995 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Humans; Phenobarbital; Phenytoin; Reference Values; Valproic Acid | 1995 |
Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Glutathione Transferase; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Ribonucleases; RNA, Messenger; Steroid Hydroxylases; Valproic Acid | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricular; Male; Midazolam; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid | 1995 |
Effect of antiepileptic drugs on absence-like seizures in the tremor rat.
Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Injections, Intraperitoneal; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Seizures; Time Factors; Trimethadione; Valproic Acid | 1995 |
Reduced carnitine and antiepileptic drugs: cause relationship or co-existence?
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Longitudinal Studies; Male; Phenobarbital; Valproic Acid | 1995 |
The stability of anticonvulsant drugs in whole blood.
Topics: Anticonvulsants; Carbamazepine; Drug Stability; Drug Storage; Humans; Phenobarbital; Phenytoin; Temperature; Valproic Acid | 1994 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphins; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Peptide Fragments; Phenobarbital; Phenytoin; Seizures; Sodium Channels; Synaptic Transmission; Valproic Acid | 1994 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans; Jaundice; Liver; Male; Mannitol; Necrosis; Neomycin; Phenobarbital; Valproic Acid | 1994 |
[Anticonvulsant and neurotoxic effects of various combinations of phenobarbital, diazepam, sodium valproate, and 1,4-dihydropyridine ryodipine].
Topics: Animals; Anticonvulsants; Diazepam; Drug Combinations; Drug Synergism; Mice; Nervous System; Nifedipine; Phenobarbital; Valproic Acid | 1994 |
Long-term preservation and induction of drug metabolizing enzymes in co-cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Valproic Acid | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; Humans; Male; Netherlands; Phenobarbital; Phenytoin; Primidone; Quality of Health Care; Statistics, Nonparametric; Treatment Outcome; Valproic Acid; Vigabatrin | 1994 |
[Effect of sodium valproate, phenobarbital and diazepam during their combined use on convulsions induced by electroshock in mice].
Topics: Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Electroshock; Mice; Phenobarbital; Seizures; Valproic Acid | 1993 |
[Antioxidative activity of drugs used in anticonvulsive therapy].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antioxidants; Benzodiazepines; Benzodiazepinones; In Vitro Techniques; Lipid Peroxidation; Models, Biological; Phenobarbital; Phenytoin; Rats; Valproic Acid | 1993 |
Valproic acid intensifies the depressant action of phenobarbital and ethanol by a pharmacodynamic mechanism.
Topics: Animals; Depression, Chemical; Drug Synergism; Ethanol; Female; Phenobarbital; Rats; Valproic Acid | 1994 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroshock; Epilepsies, Partial; Epilepsy, Generalized; Glutamates; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Valproic Acid | 1993 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female; Flumazenil; Humans; Midazolam; Phenobarbital; Seizures; Status Epilepticus; Valproic Acid | 1993 |
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Phenobarbital; Phenytoin; Seizures; Theophylline; Valproic Acid | 1993 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobarbital; Valproic Acid | 1993 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Resistance; Electric Stimulation; Electrodes, Implanted; Epilepsies, Partial; Female; Kindling, Neurologic; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid; Vigabatrin | 1993 |
[Encephalopathy associated with hyperammonemia in an alcoholic patient treated with sodium valproate].
Topics: Ammonia; Brain Diseases; Drug Therapy, Combination; Humans; Male; Middle Aged; Phenobarbital; Psychoses, Alcoholic; Valproic Acid | 1993 |
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. II. Influence of phenobarbital comedication.
Topics: Animals; Anticonvulsants; Drug Interactions; Fatty Acids, Monounsaturated; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Valproic Acid | 1993 |
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin].
Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Humans; Inclusion Bodies; Male; Phenobarbital; Seizures; Skin; Valproic Acid | 1993 |
Pharmacokinetic interaction of zonisamide in rats. Effect of zonisamide on other antiepileptics.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Interactions; Erythrocytes; In Vitro Techniques; Isoxazoles; Male; Phenobarbital; Phenytoin; Protein Binding; Rats; Rats, Wistar; Valproic Acid; Zonisamide | 1993 |
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phenobarbital; Phenytoin; Prospective Studies; Scotland; Time Factors; Valproic Acid | 1993 |
An audit of therapeutic drug monitoring of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Northern Ireland; Phenobarbital; Phenytoin; Valproic Acid | 1995 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuximide; Kindling, Neurologic; Learning Disabilities; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Seizures; Valproic Acid | 1995 |
A model for estimating individualized valproate clearance values in children.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Metabolic Clearance Rate; Models, Theoretical; Pharmacokinetics; Phenobarbital; Phenytoin; Valproic Acid | 1995 |
Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
Topics: Animals; Anticonvulsants; Caffeine; Electroshock; Male; Mice; Phenobarbital; Seizures; Valproic Acid | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Male; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Severity of Illness Index; Valproic Acid | 1996 |
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Oxygen Radioisotopes; Phenobarbital; Phenytoin; Tomography, Emission-Computed; Valproic Acid; Water | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Ear; Electrodes; Electroshock; Ethosuximide; Injections, Intravenous; Male; Mice; Morphine; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1996 |
Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions.
Topics: Animals; Anticonvulsants; Bile; Drug Interactions; Liver; Male; Models, Biological; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Rats, Sprague-Dawley; Valproic Acid | 1996 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; Epilepsy; Female; Humans; Hypothyroidism; Male; Middle Aged; Phenobarbital; Phenytoin; Prospective Studies; Thyroid Gland; Thyroid Hormones; Thyrotropin; Valproic Acid | 1995 |
Comparing antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1996 |
Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
Topics: Analysis of Variance; Animals; Anticonvulsants; Ascorbic Acid; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Glutathione; Homeostasis; L-Lactate Dehydrogenase; Liver; Male; Mass Spectrometry; Methionine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Valproic Acid; Vitamin E | 1996 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate; Obesity; Phenobarbital; Phenytoin; Valproic Acid; Weight Loss | 1996 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; gamma-Aminobutyric Acid; Lithium Chloride; Male; Neuroprotective Agents; Pentobarbital; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Valproic Acid | 1996 |
[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Lipids; Lipoproteins; Male; Phenobarbital; Time Factors; Valproic Acid | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Valproic Acid; Zonisamide | 1996 |
Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Software; Valproic Acid | 1996 |
Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Depression, Chemical; Drug Evaluation, Preclinical; Electric Stimulation; Electroencephalography; Enzyme Inhibitors; Epilepsy; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Neural Inhibition; Phenobarbital; Rats; Valproic Acid | 1996 |
[Epileptic seizures during sleep].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Generalized; Female; Humans; Male; Middle Aged; Phenobarbital; Sleep; Valproic Acid | 1996 |
Population pharmacokinetics of felbamate in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Felbamate; Humans; Infant; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Seizures; Valproic Acid | 1997 |
The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Male; N-Methylaspartate; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Valproic Acid | 1997 |
Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Female; Glucuronates; Glucuronosyltransferase; Irinotecan; Metabolic Clearance Rate; Phenobarbital; Rats; Rats, Wistar; Valproic Acid | 1997 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Isoxazoles; Male; Phenobarbital; Time Factors; Valproic Acid; Zonisamide | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Carbamazepine; Dantrolene; Dihydropyridines; Disease Models, Animal; Drug Interactions; Electroshock; Epilepsy; Female; Isradipine; Lethal Dose 50; Mice; Motor Activity; Phenobarbital; Phenytoin; Random Allocation; Seizures; Valproic Acid | 1997 |
Prognostic factors for childhood and juvenile absence epilepsies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Follow-Up Studies; Humans; Male; Phenobarbital; Prognosis; Retrospective Studies; Time Factors; Valproic Acid | 1997 |
[Clinical workload at the outpatient neuropediatric clinic].
Topics: Adolescent; Ambulatory Care; Brain Diseases; Child; Child, Preschool; Electroencephalography; Female; Health Services; Humans; Incidence; Infant; Infant, Newborn; Information Systems; Male; Neurology; Pediatrics; Phenobarbital; Prevalence; Spain; Valproic Acid | 1997 |
[Sturge-Weber syndrome: experience with 14 cases].
Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Medical Records; Phenobarbital; Retrospective Studies; Sturge-Weber Syndrome; Tomography, X-Ray Computed; Valproic Acid | 1997 |
N6-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive activity of antiepileptic drugs.
Topics: Adenosine; Animals; Anticonvulsants; Body Temperature; Carbamazepine; Darkness; Drug Synergism; Electroshock; Female; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Purinergic P1 Receptor Agonists; Valproic Acid | 1997 |
Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Phenobarbital; Valproic Acid | 1997 |
Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carbamazepine; Cohort Studies; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Procarbazine; Retrospective Studies; Valproic Acid | 1997 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Dizziness; Electroencephalography; Emergency Service, Hospital; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Middle Aged; Neurologic Examination; Phenobarbital; Primidone; Status Epilepticus; Valproic Acid | 1997 |
Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; GABA Agents; Humans; Infant; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Phenobarbital; Valproic Acid | 1997 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Liability, Legal; Male; Medical History Taking; Middle Aged; Patient Care Planning; Phenobarbital; Phenytoin; Valproic Acid | 1998 |
The influence of L-NG-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Drug Antagonism; Electroshock; Enzyme Inhibitors; Female; Memory; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1998 |
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Prospective Studies; Regression Analysis; Sex Factors; Valproic Acid | 1998 |
Veratridine-treated brain slices: a cellular model for epileptiform activity.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Electrophysiology; Epilepsy; In Vitro Techniques; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Valproic Acid; Veratridine | 1998 |
Does antiepileptic therapy affect immune response?
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cytokines; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lamotrigine; Male; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Receptors, Interleukin-2; Triazines; Valproic Acid | 1998 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Female; Phenobarbital; Rats; Rats, Wistar; Seizures; Time Factors; Valproic Acid | 1998 |
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Maze Learning; Phenobarbital; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stress, Physiological; Valproic Acid | 1998 |
Valproate-induced epileptic tonic status.
Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Male; Phenobarbital; Status Epilepticus; Valproic Acid | 1998 |
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy, Combination; Electroencephalography; Epilepsy; Felbamate; Female; Humans; Phenobarbital; Phenylcarbamates; Propylene Glycols; Syndrome; Valproic Acid | 1998 |
Rimcazole, a sigma receptor ligand, and the anticonvulsive action of conventional antiepileptic drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbazoles; Differential Threshold; Drug Synergism; Electroshock; Female; Ligands; Memory; Mice; Motor Activity; Neuroprotective Agents; Phenobarbital; Receptors, sigma; Valproic Acid | 1998 |
Serum lipids and lipoproteins in patients treated with antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Apolipoprotein A-I; Apolipoproteins B; Carbamazepine; Cholesterol; Epilepsy; Female; Humans; Lipids; Lipoprotein(a); Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Phenobarbital; Time Factors; Triglycerides; Valproic Acid | 1998 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1999 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Ethosuximide; Male; Mice; Nitroarginine; Pentylenetetrazole; Phenobarbital; Psychomotor Performance; Seizures; Valproic Acid | 1999 |
Lamotrigine drug interactions in a TDM material.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle Aged; Phenobarbital; Phenytoin; Triazines; Valproic Acid | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Male; Models, Genetic; Mutation; Phenobarbital; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Valproic Acid | 1999 |
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval; Drug Monitoring; Drug Prescriptions; Epilepsy; Europe; History, 20th Century; Humans; Phenobarbital; Phenytoin; Polypharmacy; Valproic Acid | 1999 |
[Increased fracture risk in a 67-year-old patient with hypocalcemia of unknown etiology].
Topics: Aged; Anticonvulsants; Biopsy; Bone and Bones; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Femoral Neck Fractures; Fractures, Spontaneous; Humans; Hyperparathyroidism, Secondary; Hypocalcemia; Osteomalacia; Phenobarbital; Valproic Acid | 1999 |
[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Fatal Outcome; Female; Humans; Infant; Infant, Newborn; Laryngeal Neoplasms; Male; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Respiratory Sounds; Syndrome; Valproic Acid; Vocal Cords | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Mice; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1999 |
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Male; Phenobarbital; Thyrotropin; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine; Valproic Acid | 1999 |
The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Periodicity; Phenobarbital; Seasons; Seizures; Valproic Acid | 2000 |
Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Dizocilpine Maleate; Female; Guanidines; Mice; Phenobarbital; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Valproic Acid | 1999 |
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamazepine; Entorhinal Cortex; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Male; Pentobarbital; Phenobarbital; Phenytoin; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 2000 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Erectile Dysfunction; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Middle Aged; Phenobarbital; Phenytoin; Sexual Dysfunctions, Psychological; Triazines; Valproic Acid | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Senegal; Socioeconomic Factors; Valproic Acid | 1999 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Synergism; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Periodicity; Phenobarbital; Rats; Rats, Wistar; Seasons; Valproic Acid | 2000 |
[Antiepileptic drugs and carnitine].
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Valproic Acid | 2000 |
The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy.
Topics: Anticonvulsants; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Carbamazepine; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Epilepsy; Female; Humans; Lipids; Male; Phenobarbital; Reference Values; Time Factors; Triglycerides; Valproic Acid | 2000 |
Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Body Weight; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Metabolic Clearance Rate; Phenobarbital; Reference Values; Regression Analysis; Valproic Acid | 2000 |
Renal tubular function in patients receiving anticonvulsant therapy: a long-term study.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Longitudinal Studies; Male; Phenobarbital; Valproic Acid | 2000 |
Effects of antiepileptic drugs on evoked potentials in epileptic children.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Visual; Female; Humans; Male; Phenobarbital; Prospective Studies; Valproic Acid | 2000 |
Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Epilepsy; Event-Related Potentials, P300; Female; Humans; Male; Phenobarbital; Retrospective Studies; Valproic Acid; Wechsler Scales | 2001 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnormalities; Epilepsy; Face; Female; Fetal Growth Retardation; Fingers; Humans; Infant, Newborn; Logistic Models; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Valproic Acid | 2001 |
Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios.
Topics: Adolescent; Anticonvulsants; Biological Availability; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Japan; Phenobarbital; Retrospective Studies; Valproic Acid | 2000 |
Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol, HDL; Epilepsy; Female; Humans; Infant; Lipoproteins; Male; Phenobarbital; Triglycerides; Valproic Acid | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
[Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report].
Topics: Adult; Anticonvulsants; Cranial Sutures; Craniosynostoses; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Tomography, X-Ray Computed; Valproic Acid | 2001 |
[Lafora's disease: one of the causes for drug-resistant epilepsy in adolescence].
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Drug Therapy, Combination; Electroencephalography; Female; Follow-Up Studies; Humans; Lafora Disease; Phenobarbital; Time Factors; Valproic Acid | 2001 |
Treatment of febrile seizures: the influence of treatment efficacy and side-effect profile on value to parents.
Topics: Adult; Anticonvulsants; Anxiety; Attitude; Child, Preschool; Diazepam; Educational Status; Female; Humans; Income; Infant; Male; Parents; Phenobarbital; Secondary Prevention; Seizures, Febrile; Surveys and Questionnaires; Treatment Outcome; Valproic Acid | 2001 |
Serum lipid changes during anticonvulsive treatment serum lipids in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Enzyme Induction; Epilepsy; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lipids; Liver; Male; Phenobarbital; Triglycerides; Valproic Acid | 2001 |
[Treatment of febrile convulsions].
Topics: Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Child, Preschool; Diazepam; Double-Blind Method; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Prospective Studies; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Seizures, Febrile; Time Factors; Valproic Acid | 2002 |
The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C gamma in immature rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Carbamazepine; Hippocampus; Immunohistochemistry; Isoenzymes; Learning; Male; Memory Disorders; Phenobarbital; Protein Kinase C; Rats; Rats, Wistar; Space Perception; Valproic Acid | 2002 |
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seizures; Treatment Outcome; Valproic Acid | 2002 |
Phenobarbital-induced atypical absence seizure in benign childhood epilepsy with centrotemporal spikes.
Topics: Anticonvulsants; Child; Drug Interactions; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Epilepsy, Rolandic; Female; Humans; Phenobarbital; Treatment Outcome; Valproic Acid | 2002 |
Evaluation of fluorescence polarization assays for measuring valproic acid, phenytoin, carbamazepine and phenobarbital in serum.
Topics: Anticonvulsants; Automation; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization; Humans; Phenobarbital; Phenytoin; Reproducibility of Results; Valproic Acid | 2002 |
Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Topics: Acoustic Stimulation; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Atenolol; Body Temperature; Carbamazepine; Epilepsy, Reflex; Female; Lamotrigine; Male; Metoprolol; Mice; Mice, Inbred DBA; Motor Activity; Phenobarbital; Propanolamines; Propranolol; Stereoisomerism; Triazines; Valproic Acid | 2002 |
Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitoring; Humans; Immunoassay; Phenobarbital; Phenytoin; Reproducibility of Results; Sensitivity and Specificity; Uremia; Valproic Acid | 2002 |
In vitro removal of therapeutic drugs with a novel adsorbent system.
Topics: Adsorption; Anti-Bacterial Agents; Biocompatible Materials; Carbamazepine; Digoxin; Glycopeptides; Hemoperfusion; Humans; Models, Biological; Phenobarbital; Phenytoin; Sorption Detoxification; Theophylline; Uremia; Valproic Acid | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Hippocampus; In Vitro Techniques; Lamotrigine; Methylazoxymethanol Acetate; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazines; Valproic Acid | 2002 |
Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Partial; Ethosuximide; Female; Forecasting; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Valproic Acid | 2002 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Levetiracetam; Male; Microinjections; Phenobarbital; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Hospitals, Teaching; Humans; Infant; Male; Middle Aged; Phenobarbital; Phenytoin; Polypharmacy; Valproic Acid | 2003 |
Effects of valproic acid, carbamazepine, and phenobarbitone on the fatty acid composition of erythrocyte membranes in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocyte Membrane; Fatty Acids; Female; Humans; Infant; Male; Phenobarbital; Reference Values; Valproic Acid | 2003 |
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Topics: Animals; Anticonvulsants; Biotransformation; Cytochrome P-450 Enzyme System; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Lipid Peroxides; Liver; Male; Oxidative Stress; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Triazoles; Valproic Acid | 2003 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pair 4; Craniofacial Abnormalities; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emergency Medical Services; Epilepsy, Tonic-Clonic; Female; Humans; Infusions, Intravenous; Phenobarbital; Status Epilepticus; Syndrome; Thiopental; Valproic Acid | 2003 |
Cost of epilepsy in patients attending a secondary-level hospital in India.
Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalization; Humans; India; Phenobarbital; Phenytoin; Valproic Acid | 2004 |
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Triglycerides; Valproic Acid | 2004 |
Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7.
Topics: Anticonvulsants; Breast Neoplasms; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Estrogens; Female; Humans; Lamotrigine; Phenobarbital; Phenytoin; Protein Binding; Receptors, Estrogen; Triazines; Valproic Acid | 2004 |
Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats.
Topics: Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Male; Mice; Nicardipine; Phenobarbital; Random Allocation; Rats; Rats, Wistar; Semicarbazides; Valproic Acid | 2004 |
Therapeutic doses of topiramate are not toxic to the developing rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Dose-Response Relationship, Drug; Fructose; Neurons; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Topiramate; Valproic Acid | 2004 |
Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Metabolic Clearance Rate; Methods; Models, Biological; Pharmacokinetics; Phenobarbital; Phenytoin; Regression Analysis; Valproic Acid | 2004 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Pyridoxal Phosphate; Sensitivity and Specificity; Transaminases; Valproic Acid | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combinations; Drug Synergism; Electroshock; Epilepsy; Epilepsy, Absence; Hippocampus; Male; Mice; Mice, Inbred DBA; Neuroprotective Agents; Phenobarbital; Phenytoin; Piracetam; Valproic Acid | 2004 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug Hypersensitivity; Ethosuximide; Fever; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lymphatic Diseases; Phenobarbital; Phenytoin; Syndrome; Triazines; Valproic Acid | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Felbamate; Female; Humans; Lethal Dose 50; Mice; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid | 2004 |
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Services Needs and Demand; Humans; Phenobarbital; Phenytoin; Prevalence; Valproic Acid | 2004 |
Fracture risk associated with use of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female; Fractures, Bone; Humans; Male; Middle Aged; Pharmacoepidemiology; Phenobarbital; Risk Factors; Valproic Acid | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsy; Female; Kindling, Neurologic; Male; Mineralocorticoid Receptor Antagonists; Phenobarbital; Rats; Rats, Wistar; Seizures; Spironolactone; Valproic Acid | 2005 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Riluzole; Seizures; Valproic Acid | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Combinations; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Valproic Acid; Zonisamide | 2004 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; Middle Aged; Phenobarbital; Phenytoin; Platelet Aggregation; Psychotropic Drugs; Thrombocytopenia; Triazines; Valproic Acid | 2004 |
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Rolandic; Female; Follow-Up Studies; Humans; Infant; Male; Patient Care Planning; Phenobarbital; Practice Guidelines as Topic; Practice Patterns, Physicians'; Retrospective Studies; Valproic Acid | 2004 |
Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
Topics: Animals; Anticonvulsants; Benzodiazepines; Body Temperature; Drug Therapy, Combination; Female; Hypothermia; Mice; Phenobarbital; Valproic Acid | 2004 |
Gingival enlargement in children treated with antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cross-Sectional Studies; Dental Plaque Index; Epilepsy; Female; Gingival Overgrowth; Humans; Male; Periodontal Index; Phenobarbital; Risk Factors; Severity of Illness Index; Toothbrushing; Valproic Acid | 2004 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotrigine; Phenobarbital; Phenytoin; Prohibitins; Registries; Reproducibility of Results; Risk Assessment; Risk Factors; Stevens-Johnson Syndrome; Triazines; Valproic Acid | 2005 |
Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats.
Topics: Animals; Camphanes; Chromatography; Chromatography, Liquid; Dinoprost; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Free Radicals; Glucuronic Acid; Lipid Peroxidation; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oxidative Stress; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors; Valproic Acid; Vasoconstrictor Agents | 2005 |
Fit for a fracture.
Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fractures, Spontaneous; Humans; Mental Disorders; Middle Aged; Osteoporosis; Phenobarbital; Phenytoin; Treatment Outcome; Valproic Acid; Vitamin D; Vitamin D Deficiency | 2005 |
[Rickets. A rare complication of anti-epileptic treatments. Report of two cases in children].
Topics: Anticonvulsants; Black People; Calcifediol; Child; Contraindications; Drug Monitoring; Electroencephalography; Epilepsies, Myoclonic; Ergocalciferols; Ethosuximide; Humans; Male; Phenobarbital; Phenytoin; Radiography; Rare Diseases; Rickets; Valproic Acid | 1976 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.
Topics: 3T3 Cells; Aggrecans; Animals; Anticonvulsants; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Calcification, Physiologic; Cartilage; Cell Differentiation; Cell Line, Tumor; Chondrocytes; Chondrogenesis; Chondroitin Sulfate Proteoglycans; Clone Cells; Collagen Type II; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Gene Expression; Hedgehog Proteins; Lectins, C-Type; Mice; Parathyroid Hormone-Related Protein; Patched Receptors; Patched-1 Receptor; Phenobarbital; Phenytoin; Proteins; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trans-Activators; Valproic Acid | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Learning Disabilities; Phenobarbital; Seizures; Status Epilepticus; Thiopental; Valproic Acid | 2005 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fructose; Humans; Magnetic Resonance Imaging; Phenobarbital; Phenytoin; Topiramate; Valproic Acid | 2005 |
2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Glutamate Carboxypeptidase II; Male; Mice; Organophosphorus Compounds; Phenobarbital; Phenytoin; Psychomotor Performance; Seizures; Valproic Acid | 2006 |
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.
Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Levetiracetam; Middle Aged; Myoclonus; Phenobarbital; Piracetam; Valproic Acid; Zonisamide | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2006 |
Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic?
Topics: Adolescent; Anticonvulsants; Apolipoproteins; Atherosclerosis; Carbamazepine; Child; Cholesterol, HDL; Epilepsy; Female; Humans; Lipids; Lipoproteins; Male; Phenobarbital; Valproic Acid | 2006 |
The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children.
Topics: Anticonvulsants; Antioxidants; Bilirubin; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipid Peroxides; Male; Oxidative Stress; Peroxides; Phenobarbital; Serum Albumin; Uric Acid; Valproic Acid | 2007 |
Treatment of status epilepticus in adults: guidelines of the Italian League against Epilepsy.
Topics: Adult; Age Factors; Anesthesia, General; Anticonvulsants; Benzodiazepines; Humans; International Agencies; Italy; Lorazepam; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Propofol; Secondary Prevention; Status Epilepticus; Thiopental; Valproic Acid | 2006 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Electric Stimulation; Epilepsies, Partial; Ethosuximide; Female; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Predictive Value of Tests; Reproducibility of Results; Species Specificity; Treatment Outcome; Valproic Acid | 2007 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 8; Clone Cells; Cocarcinogenesis; Drug Therapy, Combination; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Leukemia, Myeloid; Levetiracetam; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Phenobarbital; Piracetam; Translocation, Genetic; Triazines; Valproic Acid; Zonisamide | 2008 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Monitoring; Epilepsy; Female; Gene Frequency; Genetics, Population; Heterozygote; Homozygote; Humans; Immunoassay; Isoxazoles; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Polymorphism, Genetic; Regression Analysis; Valproic Acid; Zonisamide | 2007 |
Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Drug Utilization Review; Female; Fructose; Hallucinations; Humans; Hyperammonemia; Infusions, Intravenous; Male; Medical Records; Metabolic Clearance Rate; Migraine Disorders; Phenobarbital; Phenytoin; Retrospective Studies; Seizures; Topiramate; Treatment Outcome; Valproic Acid | 2007 |
[Experimental study on the possibility of brain damage induced by chronic treatment with phenobarbital, clonazepam, valproic acid and topiramate in immature rats].
Topics: Age Factors; Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Diseases; Clonazepam; Microscopy, Electron, Transmission; Neurons; Phenobarbital; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Valproic Acid | 2007 |
Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Drug Synergism; Electroshock; Fluoxetine; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Selective Serotonin Reuptake Inhibitors; Valproic Acid | 2007 |
Interactions between two enantiomers of losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model--an isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; Furans; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Stereoisomerism; Valproic Acid | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Epilepsy; Epilepsy, Tonic-Clonic; Male; Memory; Mice; Motor Skills; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2007 |
Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Cattle; Chromatography, High Pressure Liquid; Drug Monitoring; Ethosuximide; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Primidone; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Solutions; Specimen Handling; Spectrophotometry, Ultraviolet; Temperature; Triazines; Valproic Acid; Zonisamide | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Injections, Intraperitoneal; Male; Mental Recall; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Vitamins | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Electroshock; Fluorescent Antibody Technique; Male; Memory; Mianserin; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2007 |
[Evaluation of bone mineral density using digital image processing in children receiving anticonvulsants].
Topics: Absorptiometry, Photon; Adolescent; Age Determination by Skeleton; Anticonvulsants; Bone Density; Carbamazepine; Child; Child, Preschool; Female; Humans; Male; Phenobarbital; Valproic Acid | 2007 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, Health; Cohort Studies; Cyclohexanecarboxylic Acids; Drug Prescriptions; Drug Utilization; Epilepsy; Family Practice; Female; Gabapentin; gamma-Aminobutyric Acid; Geography; Humans; Italy; Longitudinal Studies; Male; Middle Aged; Mood Disorders; Pain; Pharmacoepidemiology; Phenobarbital; Practice Patterns, Physicians'; Prevalence; Valproic Acid | 2007 |
Aseptic meningitis associated with lamotrigine: report of two cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anticonvulsants; Blood; Blood Chemical Analysis; Cerebrospinal Fluid; Diagnosis, Differential; Female; Fever; Humans; Lamotrigine; Male; Meningitis, Aseptic; Meningitis, Bacterial; Meningitis, Viral; Phenobarbital; Triazines; Valproic Acid | 2007 |
The effect of anticonvulsant drugs on the fibrinolytic activity of tissue plasminogen activator.
Topics: Adult; Anticonvulsants; Blood Coagulation; Drug Interactions; Erythropoietin; Female; Fibrinolytic Agents; Humans; In Vitro Techniques; Levetiracetam; Male; Phenobarbital; Phenytoin; Piracetam; Recombinant Proteins; Tissue Plasminogen Activator; Valproic Acid | 2008 |
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
[Study of oro-dental injuries during seizures in Senegalese children with epilepsy].
Topics: Accidental Falls; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Mouth; Phenobarbital; Prospective Studies; Senegal; Tooth Injuries; Valproic Acid | 2007 |
Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model.
Topics: Agmatine; Animals; Anticonvulsants; Avoidance Learning; Drug Interactions; Drug Synergism; Electroshock; Hand Strength; Male; Mice; Muscle Strength; Phenobarbital; Postural Balance; Psychomotor Performance; Seizures; Valproic Acid | 2008 |
Factor VII deficiency associated with valproate treatment.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Factor VII; Factor VII Deficiency; Follow-Up Studies; Humans; Male; Phenobarbital; Seizures; Valproic Acid | 2008 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, Reducing; Drug Combinations; Electroencephalography; Epilepsy, Tonic-Clonic; Estrogens, Conjugated (USP); Fatal Outcome; Female; Headache; Hormone Replacement Therapy; Humans; Magnetic Resonance Imaging; Medroxyprogesterone Acetate; Middle Aged; Phenobarbital; Phenytoin; Porphyrias; Spinal Puncture; Tomography, X-Ray Computed; Valproic Acid; Vomiting; Weight Loss | 2008 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Electroencephalography; Electromyography; Epilepsies, Myoclonic; Epilepsies, Partial; Female; Humans; Male; Oxcarbazepine; Phenobarbital; Seizures; Valproic Acid | 2009 |
[Eclampsia at a teaching hospital in Ivory Coast: management, outcome and prognostic factors].
Topics: Adolescent; Adult; Anticonvulsants; Antihypertensive Agents; Cote d'Ivoire; Diazepam; Eclampsia; Female; Humans; Phenobarbital; Pregnancy; Prognosis; Retrospective Studies; Risk Factors; Treatment Outcome; Valproic Acid | 2008 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Liver; Male; Methionine; Oxidation-Reduction; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Riboflavin; Valproic Acid; Vitamin B Deficiency | 2008 |
[The effect of prophylactic therapy with valproate sodium and phenobarbital in two patients with cyclic vomiting syndrome].
Topics: Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Male; Phenobarbital; Valproic Acid; Vomiting | 2008 |
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Male; Mice; Phenobarbital; Valproic Acid; Xanthines | 2008 |
Long-term antiepileptic drug administration during early life inhibits hippocampal neurogenesis in the developing brain.
Topics: Age Factors; Animals; Animals, Suckling; Anticonvulsants; Apoptosis; Brain Damage, Chronic; Carbamazepine; Cell Division; Clonazepam; Dentate Gyrus; DNA Replication; Doublecortin Protein; Fructose; Hippocampus; Neurogenesis; Neurons; Phenobarbital; Random Allocation; Rats; Rats, Sprague-Dawley; Topiramate; Valproic Acid | 2009 |
N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Synergism; Male; Memory; Mice; Models, Animal; Motor Activity; Muscle Strength; Phenobarbital; Phenytoin; Seizures; Succinimides; Valproic Acid | 2009 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy; Levetiracetam; Male; Mice; Phenobarbital; Piracetam; Psychomotor Performance; Valproic Acid | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Piracetam; Seizures; Valproic Acid | 2009 |
Chitosan may decrease serum valproate and increase the risk of seizure reappearance.
Topics: Adult; Anti-Obesity Agents; Anticonvulsants; Chitosan; Dietary Supplements; Drug Interactions; Epilepsy, Generalized; Female; Humans; Phenobarbital; Recurrence; Risk Factors; Valproic Acid | 2009 |
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Epilepsy; Female; Genotype; Humans; Male; Pharmacogenetics; Phenobarbital; Phenytoin; Valproic Acid; Young Adult | 2010 |
[Prophylactic efficacy of levetiracetam, valproate or phenobarbital on febrile convulsions in rats].
Topics: Animals; Anticonvulsants; Levetiracetam; Male; Phenobarbital; Piracetam; Rats; Recurrence; Seizures, Febrile; Valproic Acid | 2010 |
Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Female; Genetic Variation; Humans; Infant; Male; Phenobarbital; Seizures; Sleep; Syndrome; Valproic Acid | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Male; Memory; Mice; Motor Activity; Muscle Strength; Muscle, Skeletal; Phenobarbital; Phenytoin; Seizures; Succinimides; Valproic Acid | 2010 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; China; Clonazepam; Cyclohexanecarboxylic Acids; Exanthema; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Male; Medicine, Chinese Traditional; Middle Aged; Phenobarbital; Phenytoin; Piracetam; Retrospective Studies; Topiramate; Triazines; Valproic Acid; Young Adult | 2010 |
Factors influencing valproate pharmacokinetics in children and adults.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Models, Biological; Phenobarbital; Serbia; Valproic Acid; Young Adult | 2010 |
Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Statistics, Nonparametric; Treatment Outcome; Valproic Acid | 2010 |
Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Diagnosis, Differential; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Fructose; Humans; Lamotrigine; Phenobarbital; Secondary Prevention; Status Epilepticus; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Weight Gain | 2010 |
Status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Clinical Protocols; Fructose; GABA Modulators; Humans; Ketamine; Levetiracetam; Midazolam; Pentobarbital; Phenobarbital; Phenytoin; Piracetam; Propofol; Status Epilepticus; Thiopental; Topiramate; Valproic Acid | 2011 |
Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Agonists; Carbamazepine; Drug Synergism; Electroshock; Male; Memory, Long-Term; Mice; Morpholines; Muscle Strength; Naphthalenes; Phenobarbital; Phenytoin; Psychomotor Performance; Seizures; Valproic Acid | 2011 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; Humans; Immunosuppressive Agents; Intellectual Disability; Lamotrigine; Lennox Gastaut Syndrome; Liver Function Tests; Liver Transplantation; Phenobarbital; Seizures; Spasms, Infantile; Topiramate; Triazines; Valproic Acid; Young Adult | 2011 |
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Hyperthyroidism; Hypothyroidism; Intellectual Disability; Lamotrigine; Linear Models; Male; Middle Aged; Netherlands; Phenobarbital; Phenytoin; Prevalence; Thyroid Gland; Thyrotropin; Thyroxine; Triazines; Triiodothyronine; Valproic Acid | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Male; Maze Learning; Phenobarbital; Phenytoin; Random Allocation; Rats; Rats, Wistar; Valproic Acid | 2011 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lamotrigine; Male; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Prospective Studies; Registries; Triazines; Valproic Acid | 2011 |
Hyperammonemic encephalopathy related to valproate, phenobarbital, and topiramate synergism.
Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Middle Aged; Neurotoxicity Syndromes; Phenobarbital; Topiramate; Valproic Acid | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Clonazepam; Disease Models, Animal; Drug Synergism; Ethosuximide; Hand Strength; Male; Mice; Morpholines; Naphthalenes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; Female; Fructose; Humans; Lamotrigine; Magnetic Resonance Imaging; Male; Middle Aged; Patient Compliance; Phenobarbital; Phenytoin; Topiramate; Triazines; Valproic Acid | 2011 |
Antiepleptic drug interactions: a clinical case demonstration.
Topics: Adolescent; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbital; Primidone; Valproic Acid | 2011 |
Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients.
Topics: Acetylation; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Epigenomics; Epilepsy; Female; Histones; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Phenobarbital; Valproic Acid | 2012 |
Gingival overgrowth in partially edentulous ridges in an elderly female patient with epilepsy: a case report.
Topics: Anticonvulsants; Denture, Complete; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Gingiva; Gingival Hyperplasia; Gingival Overgrowth; Gingivectomy; Humans; Jaw, Edentulous, Partially; Middle Aged; Phenobarbital; Phenytoin; Tooth Extraction; Tooth Mobility; Valproic Acid | 2012 |
Prevalence of seizures in children infected with human immunodeficiency virus.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; HIV Infections; Humans; Male; Phenobarbital; Prevalence; Retrospective Studies; Seizures; South Africa; Valproic Acid | 2013 |
Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; China; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenobarbital; Primary Health Care; Rural Population; Treatment Outcome; Valproic Acid; Young Adult | 2012 |
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Topics: Animals; Cell Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Hepatocytes; Male; Molecular Structure; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles; Valproic Acid | 2012 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Structure-Activity Relationship; Succinimides; Valproic Acid | 2012 |
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Drug Therapy, Combination; Epilepsy; Female; Fructose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Phenobarbital; Pilot Projects; Piracetam; Pregabalin; Quality of Life; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Young Adult | 2012 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Infant; Isoxazoles; Male; Phenobarbital; Phenytoin; Retrospective Studies; Risk Factors; Sex Factors; Topiramate; Valproic Acid; Zonisamide | 2013 |
Drug rash with eosinophilia and systemic symptoms syndrome associated with use of phenytoin, divalproex sodium, and phenobarbital.
Topics: Adult; Drug Eruptions; Drug Substitution; Eosinophilia; Female; Humans; Phenobarbital; Phenytoin; Valproic Acid | 2013 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Humans; Hypocalcemia; Male; Microcephaly; Phenobarbital; Radiography; Rickets; Valproic Acid; Vitamin D; Vitamin D Deficiency | 2013 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Complications; Registries; Seizures; Treatment Outcome; Triazines; Valproic Acid | 2013 |
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal).
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Homeodomain Proteins; Levetiracetam; Locomotion; Male; Mass Spectrometry; Phenobarbital; Piracetam; Time Factors; Transcription Factors; Valproic Acid | 2013 |
An examination of the mutual effects of valproic acid, carbamazepine, and phenobarbital on 25-hydroxyvitamin D levels and thyroid function tests.
Topics: Anticonvulsants; Carbamazepine; Child; Female; Humans; Hypothyroidism; Male; Phenobarbital; Thyroid Function Tests; Valproic Acid; Vitamin D | 2014 |
Anti-epileptic drugs inhibit viability of synoviocytes in vitro.
Topics: Animals; Anticonvulsants; Arthritis, Rheumatoid; Carbamazepine; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Histone Deacetylase Inhibitors; Humans; Phenobarbital; Phenytoin; Rabbits; Synovial Membrane; Valproic Acid | 2013 |
Effect of CYP3A5 genotypes on the pharmacokinetics of carbamazepine when used as monotherapy or co-administered with phenytoin, phenobarbital or valproic acid in Thai patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Carbamazepine; Cytochrome P-450 CYP3A; Drug Interactions; Female; Genotype; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid; Young Adult | 2013 |
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.
Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies, Partial; Epilepsy, Generalized; Female; Follow-Up Studies; Fructose; Hospitals, Teaching; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Prohibitins; Retrospective Studies; Seizures; Topiramate; Treatment Outcome; Valproic Acid | 2013 |
[Case report; drug-induced hypersensitivity syndrome following meningoencephalitis associated with human herpes virus-6].
Topics: Aged; Antiviral Agents; Biomarkers; Cytokines; Diagnosis, Differential; DNA, Viral; Drug Hypersensitivity Syndrome; Ganciclovir; Herpesvirus 6, Human; Humans; Lymphocyte Activation; Male; Meningoencephalitis; Methylprednisolone; Phenobarbital; Prednisolone; Pulse Therapy, Drug; T-Lymphocytes; Valproic Acid; Virus Activation | 2013 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Epilepsy; Male; Memory, Long-Term; Mice; Morpholines; Motor Activity; Phenobarbital; Phenytoin; Reboxetine; Valproic Acid | 2014 |
Interaction of famotidine, an H2 histamine receptor antagonist, with conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Electroshock; Famotidine; Histamine H2 Antagonists; Male; Memory, Long-Term; Mice; Phenobarbital; Phenytoin; Psychomotor Performance; Valproic Acid | 2014 |
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Environment; Epilepsy; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 2014 |
Interaction of injectable neurotropic drugs with the red cell membrane.
Topics: Central Nervous System Agents; Chlorpromazine; Citalopram; Clomipramine; Clonazepam; Diazepam; Erythrocytes; Humans; Injections; Levetiracetam; Microscopy, Electron, Scanning; Neurotransmitter Agents; Phenobarbital; Phenytoin; Piracetam; Valproic Acid | 2014 |
Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Lamotrigine; Male; Middle Aged; Models, Biological; Nonlinear Dynamics; Phenobarbital; Topiramate; Triazines; Valproic Acid | 2015 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Levetiracetam; Mice; Phenobarbital; Phenytoin; Piracetam; Seizures; Valproic Acid | 2015 |
Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzhydryl Compounds; Brain; Carbamazepine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Electroshock; Hand Strength; Male; Mice; Modafinil; Phenobarbital; Phenytoin; Psychomotor Performance; Seizures; Sulfones; Valproic Acid | 2015 |
Independent predictors of delay in emergence from general anesthesia.
Topics: Adult; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Cohort Studies; Delayed Emergence from Anesthesia; Dental Care for Disabled; Female; Follow-Up Studies; Humans; Intellectual Disability; Male; Methyl Ethers; Phenobarbital; Phenytoin; Piperidines; Propofol; Remifentanil; Retrospective Studies; Risk Factors; Sevoflurane; Valproic Acid | 2015 |
Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Male; Methoxsalen; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2015 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonidine; Diazepam; Encephalitis, Herpes Simplex; Encephalomalacia; Female; Fever; Humans; Immunocompromised Host; Immunosuppression Therapy; Infant; Leukoencephalopathies; Movement Disorders; Neurological Rehabilitation; Pakistan; Paresis; Phenobarbital; Phenytoin; Plasmapheresis; Receptors, N-Methyl-D-Aspartate; Seizures; Trihexyphenidyl; United Kingdom; Valproic Acid | 2015 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Databases, Factual; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Male; Middle Aged; Oxcarbazepine; Pharmacovigilance; Phenobarbital; Spain; Stevens-Johnson Syndrome; Triazines; Valproic Acid; Young Adult | 2015 |
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Child; China; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Epilepsy; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Phenobarbital; Phenytoin; Polymorphism, Single Nucleotide; Valproic Acid; Young Adult | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Male; Mice; Morpholines; Motor Skills; Pentylenetetrazole; Phenobarbital; Reboxetine; Valproic Acid | 2015 |
LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Anticonvulsants; Brain; Child; Child, Preschool; Classical Lissencephalies and Subcortical Band Heterotopias; Drug Resistant Epilepsy; Electroencephalography; Female; Humans; Infant; Lamotrigine; Male; Microtubule-Associated Proteins; Phenobarbital; Phenotype; Retrospective Studies; Treatment Outcome; Triazines; Valproic Acid; Vigabatrin; Young Adult | 2016 |
Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; Male; Memory, Long-Term; Mexiletine; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Tissue Distribution; Valproic Acid | 2016 |
Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Phenobarbital; Phenytoin; Propafenone; Valproic Acid | 2016 |
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Models, Biological; Oxcarbazepine; Phenobarbital; Phenytoin; Topiramate; Valproic Acid; Young Adult | 2016 |
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; Memory, Long-Term; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Lamotrigine; Levetiracetam; Male; Phenobarbital; Phenytoin; Piracetam; Triazines; Valproic Acid; Young Adult; Zonisamide | 2016 |
Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Jordan; Levetiracetam; Male; Phenobarbital; Piracetam; Practice Patterns, Physicians'; Topiramate; Valproic Acid | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; Female; Immunohistochemistry; Male; Neuropeptide Y; Pentylenetetrazole; Phenobarbital; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Valproic Acid | 2016 |
Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Dose-Response Relationship, Drug; Electroshock; Levetiracetam; Male; Memory, Long-Term; Mice; Nicotinic Agonists; Phenobarbital; Piracetam; Quinolizines; Seizures; Valproic Acid | 2017 |
[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Humans; Medication Adherence; Morocco; Phenobarbital; Retrospective Studies; Valproic Acid | 2016 |
Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Benzodiazepines; Clobazam; Cornea; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy, Complex Partial; Lacosamide; Levetiracetam; Male; Mice; Muscle Strength; Nipecotic Acids; Phenobarbital; Phenylmethylsulfonyl Fluoride; Piracetam; Psychomotor Performance; Receptor, Cannabinoid, CB1; Tiagabine; Valproic Acid | 2017 |
Treatment outcomes after the introduction of a new seizure management protocol.
Topics: Adult; Anticonvulsants; Clinical Protocols; Drug-Related Side Effects and Adverse Reactions; Emergency Service, Hospital; Female; Humans; Levetiracetam; Male; Middle Aged; Phenobarbital; Phenytoin; Piracetam; Retrospective Studies; Status Epilepticus; Treatment Outcome; Valproic Acid | 2018 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Logistic Models; Male; Oxcarbazepine; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Topiramate; Valproic Acid; Young Adult | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbamazepine; Diazepam; Disease Models, Animal; Essential Tremor; Ethosuximide; Male; Mice, Inbred Strains; Nicotine; Phenobarbital; Propranolol; Pyridines; Valproic Acid | 2018 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Dronedarone; Drug Interactions; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Male; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2019 |
Stereological examination of curcumin's effects on hippocampal damage caused by the anti-epileptic drugs phenobarbital and valproic acid in the developing rat brain.
Topics: Animals; Anticonvulsants; Curcumin; Female; Hippocampus; Male; Microscopy; Phenobarbital; Rats; Rats, Wistar; Valproic Acid | 2019 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; Seizures; Spasms, Infantile; Treatment Outcome; Valproic Acid; Vitamin B 6 | 2019 |
Etiology of neonatal seizures and maintenance therapy use: a 10-year retrospective study at Toulouse Children's hospital.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cohort Studies; Databases, Factual; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy; Female; France; Hospitals, Pediatric; Hospitals, University; Humans; Infant, Newborn; Levetiracetam; Magnetic Resonance Imaging; Male; Phenobarbital; Piracetam; Prognosis; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Rate; Term Birth; Time Factors; Treatment Outcome; Valproic Acid | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lamotrigine; Male; Phenobarbital; Seizures; Sequence Deletion; Spasms, Infantile; Valproic Acid | 2019 |
Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Phenobarbital; Rural Population; Valproic Acid; Young Adult | 2019 |
The number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study.
Topics: Anticonvulsants; Humans; Phenobarbital; Phenytoin; Propofol; Valproic Acid | 2020 |
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Democratic Republic of the Congo; Dried Blood Spot Testing; Drug Monitoring; Epilepsy; Female; Hematocrit; Humans; Male; Nodding Syndrome; Onchocerciasis; Phenobarbital; Tandem Mass Spectrometry; Uganda; Valproic Acid | 2020 |
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Mice; Nerve Agents; Phenobarbital; Soman; Status Epilepticus; Valproic Acid | 2020 |
Analytical validation of a quantitative method for therapeutic drug monitoring on the Alinity
Topics: Amikacin; Automation, Laboratory; Colorimetry; Drug Monitoring; Gentamicins; Humans; Immunoassay; Nephelometry and Turbidimetry; Phenobarbital; Phenytoin; Reproducibility of Results; Theophylline; Valproic Acid; Vancomycin | 2020 |
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid; Young Adult | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistant Epilepsy; Electroshock; Kindling, Neurologic; Lamotrigine; Levetiracetam; Locomotion; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Open Field Test; Phenobarbital; Seizures; Treatment Outcome; Valproic Acid | 2020 |
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; Phenytoin; Rotarod Performance Test; Seizures; Thiones; Triazoles; Valproic Acid | 2021 |
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epilepsy, Juvenile; Phenobarbital; Retrospective Studies; Risk Factors; Seizures; Valproic Acid; Zonisamide | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy; Female; Male; Memory, Long-Term; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2021 |
Assessment of porphyrogenicity of drugs and chemicals in selected hepatic cell culture models through a fluorescence-based screening assay.
Topics: Cell Culture Techniques; Heme; Hepatocytes; Humans; Liver; Norgestrel; Phenobarbital; Phenytoin; Porphobilinogen Synthase; Porphyrias, Hepatic; Valproic Acid | 2022 |
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid | 2022 |
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Registries; Topiramate; Valproic Acid | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Mice; Phenobarbital; Phenytoin; Trimetazidine; Valproic Acid | 2022 |
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria.
Topics: Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Delivery of Health Care; Epilepsy; Folic Acid; Humans; Nigeria; Phenobarbital; Quality of Life; Valproic Acid | 2022 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Mice; Phenobarbital; Seizures; Valproic Acid | 2023 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Humans; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Varenicline | 2023 |
Antiepileptic Drugs Modulate Alzheimer-Related Tau Aggregation in a Neuronal Activity-Independent Manner.
Topics: Aged; Alzheimer Disease; Anticonvulsants; Humans; Phenobarbital; tau Proteins; Valproic Acid | 2023 |
Genotype-phenotype correlations of STXBP1 pathogenic variants and the treatment choices for STXBP1-related disorders in China.
Topics: Adrenocorticotropic Hormone; China; Female; Genetic Association Studies; Humans; Intellectual Disability; Levetiracetam; Male; Munc18 Proteins; Nitrazepam; Phenobarbital; Phenotype; Retrospective Studies; Topiramate; Valproic Acid; Vigabatrin | 2023 |
Simultaneous determination of 24 antiepileptic drugs and their active metabolites in human plasma by UHPLC-MS/MS.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Reproducibility of Results; Tandem Mass Spectrometry; Valproic Acid | 2023 |
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Tanzania; Valproic Acid | 2023 |
Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012-2021) from a University Hospital in Germany.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Child; Female; Hospitals, University; Humans; Lacosamide; Levetiracetam; Male; Medical Records; Midazolam; Middle Aged; Phenobarbital; Phenytoin; Propofol; Status Epilepticus; Valproic Acid | 2023 |