Compounds > valproic acid

valproic acid and paclitaxel

valproic acid has been researched along with paclitaxel in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (5.88)	18.2507
2000's	6 (35.29)	29.6817
2010's	10 (58.82)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Batrakova, EV; Kabanov, AV; Li, S; Miller, DW	1
Boccuzzi, G; Catalano, MG; Fortunati, N; Poli, R; Pugliese, M	1
Bonomi, A; Cavicchini, L; Ciusani, E; Coccè, V; Gribaldo, L; Pessina, A; Sisto, F	1
Banik, NL; Karmakar, S; Ray, SK; Roy Choudhury, S	1
Atkinson, R; Buchholz, TA; Debeb, BG; Krishnamurthy, S; Lacerda, L; Larson, R; Reuben, JM; Solley, T; Sulman, EP; Ueno, NT; Woodward, WA; Xu, W	1
Annovazzi, L; Biunno, I; Cassoni, P; Cattaneo, M; De Blasio, P; Melcarne, A; Mellai, M; Schiffer, D; Storaci, AM	1
Fujimura, T; Fushida, S; Hirono, Y; Kaji, M; Kinoshita, J; Ohta, T; Oyama, K; Tsukada, T	1

Reviews

1 review(s) available for valproic acid and paclitaxel

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for valproic acid and paclitaxel

Article	Year
Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial. Drug design, development and therapy, 2016, Volume: 10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Humans; Japan; Mice; Paclitaxel; Stomach Neoplasms; Treatment Outcome; Valproic Acid	2016

Other Studies

15 other study(ies) available for valproic acid and paclitaxel

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers. Pharmaceutical research, 1999, Volume: 16, Issue:9 Topics: Animals; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Caco-2 Cells; Cattle; Contrast Media; Doxorubicin; Drug Resistance, Neoplasm; Endothelium, Vascular; Enzyme Inhibitors; Etoposide; Excipients; Fluorescein; Humans; Intestinal Absorption; Loperamide; Micelles; Microcirculation; Paclitaxel; Poloxamer; Tritium; Valproic Acid; Zidovudine	1999
Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines. Endocrine-related cancer, 2007, Volume: 14, Issue:3 Topics: Acetylation; Acetyltransferases; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Inhibitors; Humans; Paclitaxel; Thyroid Neoplasms; Tubulin; Valproic Acid	2007
A mesenchymal stromal cell line resistant to paclitaxel that spontaneously differentiates into osteoblast-like cells. Cell biology and toxicology, 2011, Volume: 27, Issue:3 Topics: Adipocytes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Cells; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chondrocytes; Drug Resistance, Neoplasm; Female; Humans; Indomethacin; Mesenchymal Stem Cells; Mice; Osteoblasts; Paclitaxel; Valproic Acid	2011
Valproic acid induced differentiation and potentiated efficacy of taxol and nanotaxol for controlling growth of human glioblastoma LN18 and T98G cells. Neurochemical research, 2011, Volume: 36, Issue:12 Topics: Albumin-Bound Paclitaxel; Albumins; Apoptosis; Apoptosis Inducing Factor; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 8; Caspase 9; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytochromes c; Down-Regulation; Drug Therapy, Combination; Glioblastoma; Humans; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Valproic Acid	2011
Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/β-catenin signaling. Stem cells (Dayton, Ohio), 2012, Volume: 30, Issue:11 Topics: Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Dedifferentiation; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Paclitaxel; Spheroids, Cellular; Tumor Cells, Cultured; Valproic Acid; Wnt Signaling Pathway	2012
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy. Oncotarget, 2015, May-20, Volume: 6, Issue:14 Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Dacarbazine; Doxorubicin; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Paclitaxel; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proteins; Temozolomide; Valproic Acid	2015