valproic acid has been researched along with norclozapine in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Longo, LP; Salzman, C | 1 |
| Baldessarini, RJ; Centorrino, F; Cohen, BM; Flood, JG; Huston-Lyons, D; Volpicelli, SA | 1 |
| Baldessarini, RJ; Centorrino, F; Flood, JG; Frankenburg, FR; Kando, J; Puopolo, PR; Volpicelli, SA | 1 |
| Avenoso, A; Facciolà, G; Madia, AG; Perucca, E; Scordo, MG; Spina, E; Ventimiglia, A | 1 |
| Ansermot, N; Crettol, S; de Leon, J; Diaz, FJ; Eap, CB; Spina, E | 1 |
| Baroni, S; Betti, L; Ciapparelli, A; DellʼOsso, L; Giannaccini, G; Lucacchini, A; Marazziti, D; Massimetti, E; Mucci, F; Palego, L | 1 |
| Deckert, J; Fischer, M; Hefner, G; Hohner, M; Hommers, L; Pfuhlmann, B; Scharl, M; Unterecker, S | 1 |
| Andreassen, OA; Haslemo, T; Kyllesø, L; Molden, E; Smith, RL | 1 |
| de Leon, J | 1 |
| Jovanović, M; Lukić, V; Miljković, B; Milovanović, S; Panić, B; Vučićević, K | 1 |
1 review(s) available for valproic acid and norclozapine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
2 trial(s) available for valproic acid and norclozapine
| Article | Year |
|---|---|
Serum concentrations of clozapine and its major metabolites: effects of cotreatment with fluoxetine or valproate.
Topics: Adult; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Psychotic Disorders; Schizophrenia; Stimulation, Chemical; Valproic Acid | 1994 |
Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mood Disorders; Schizophrenia; Valproic Acid | 1999 |
9 other study(ies) available for valproic acid and norclozapine
| Article | Year |
|---|---|
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Valproic acid effects on serum concentrations of clozapine and norclozapine.
Topics: Clozapine; Depression, Chemical; Drug Therapy, Combination; Humans; Schizophrenia; Seizures; Valproic Acid | 1995 |
Tissue concentrations of clozapine and its metabolites in the rat.
Topics: Animals; Brain; Clozapine; Fluoxetine; Half-Life; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Valproic Acid | 1993 |
Can valproic acid be an inducer of clozapine metabolism?
Topics: Antimanic Agents; Chromatography, High Pressure Liquid; Clozapine; Drug Monitoring; Female; Humans; Linear Models; Male; Mental Disorders; Sex Factors; Smoking; Valproic Acid | 2014 |
Effect of Valproate and Antidepressant Drugs on Clozapine Metabolism in Patients With Psychotic Mood Disorders.
Topics: Adolescent; Adult; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Clozapine; Drug Interactions; Female; Humans; Male; Middle Aged; Retrospective Studies; Sex Factors; Valproic Acid; Young Adult | 2018 |
Comedication of Valproic Acid Is Associated With Increased Metabolism of Clozapine.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clozapine; Drug Interactions; Drug Monitoring; Female; Humans; Male; Middle Aged; Psychotic Disorders; Retrospective Studies; Valproic Acid | 2018 |
Reduction in N-Desmethylclozapine Level Is Determined by Daily Dose But Not Serum Concentration of Valproic Acid-Indications of a Presystemic Interaction Mechanism.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Clozapine; Drug Interactions; Drug Monitoring; Female; Humans; Male; Middle Aged; Retrospective Studies; Valproic Acid; Young Adult | 2019 |
Future Studies on the Interaction Between Clozapine and Valproic Acid Should Aspire to Include Longitudinal Designs and Free Valproate Concentrations, and Should Consider that Inducer and/or Inhibitory Effects May Vary With Time, the Individual, and the A
Topics: Clozapine; Cytochrome P-450 Enzyme Inducers; Humans; Valproic Acid | 2020 |
Association of clozapine and norclozapine levels with patient and therapy characteristics-focus on interaction with valproic acid.
Topics: Clozapine; Humans; Mental Disorders; Retrospective Studies; Valproic Acid | 2023 |