valproic acid and morphine

valproic acid has been researched along with morphine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (42.50)	18.7374
1990's	2 (5.00)	18.2507
2000's	11 (27.50)	29.6817
2010's	9 (22.50)	24.3611
2020's	1 (2.50)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Chang, TK; Ensom, MH; Kiang, TK	1
Jolivette, LJ; Ward, KW	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bruinvels, J; de Boer, T; Metselaar, HJ	1
Bulaev, VM; Ostrovskaia, RU	1
Breimer, DD; de Boer, AG; van Hoogdalem, E	1
Bossut, D; Frenk, H; Mayer, DJ	1
Aley, KO; Kulkarni, SK	1
Andreev, BV; Ignatov, IuD	1
Hillen, FC; Van der Laan, JW; Van Veenendaal, W; Voorthuis, P; Weick, G	1
Chapman, AG	1
van Bleek, G; van der Laan, JW; Weick, G	1
Hancock, S; Picker, M; Poling, A; Wallace, S	1
Hillen, FC; van der Laan, JW; Weick, G	1
Bulayev, VM; Ostrovskaya, RU; Zakusov, VV	1
Bruinvels, J; van der Laan, JW	1
Contreras, E; Tamayo, L	1
van der Laan, JW	1
Katz, RJ; Schmaltz, K	1
Bruinvels, J; Cools, AR; van der Laan, JW	1
Gregus, Z; Klaassen, CD; Thompson, TN; Watkins, JB	1
Hirohashi, M; Kitano, Y; Nomura, M; Takasuna, K; Usui, C	1
Li, JX; Liang, JH; Zhang, Q	1
Mu, P; Yu, LC	1
Aoe, T; Dobashi, T; Jin, H; Nishino, T; Tanabe, S	1
Jing, L; Lawrence, AJ; Li, YL; Liang, JH; Liu, Q; Luo, J; Qin, WJ; Wang, YT; Zhang, M	1
Bhatt, J; Daugé, V; Estevez, L; Giros, B; Morel, LJ; Naudon, L; Tesone-Coelho, C; Zwiller, J	1
El-Hage, N; Hauser, KF; Knapp, PE; Masvekar, RR	1
Araki, K; Matsushita, Y; Mukae, T; Uchida, H; Ueda, H	1
Calcagno, P; Finn, DP; Hughes, EM; Kelly, JP; Roche, M; Sanchez, C; Smith, K	1

Reviews

5 review(s) available for valproic acid and morphine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs. Clinical pharmacokinetics, 1991, Volume: 21, Issue:1 Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid	1991
Valproate and myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid	1986

Other Studies

35 other study(ies) available for valproic acid and morphine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Suppression of GABA-induced abstinence behaviour in naive rats by morphine and bicuculline. Life sciences, 1977, Mar-15, Volume: 20, Issue:6 Topics: Aminobutyrates; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoquinolines; Male; Morphine; Motor Activity; Naloxone; Rats; Receptors, Drug; Receptors, Opioid; Substance Withdrawal Syndrome; Valerates; Valproic Acid	1977
[Effect of GABA-ergic substances on the analgesic effect of morphine in rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:7 Topics: Analgesia; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Male; Morphine; Rats; Receptors, Drug; Thiosemicarbazones; Time Factors; Valproic Acid; Vocalization, Animal	1979
Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds. Brain research, 1988, Jul-12, Volume: 455, Issue:2 Topics: Animals; Anticonvulsants; Chlordiazepoxide; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P; Valproic Acid	1988
GABAergic agents-induced antinociceptive effect in mice. Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:10 Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; Muscimol; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Valproic Acid	1989
[Role of opioid and adrenergic mechanisms in the analgesic action of GABA-positive drugs]. Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:5 Topics: 4-Aminobutyrate Transaminase; Analgesics; Animals; Baclofen; Clonidine; Drug Tolerance; Female; Male; Morphine; Nociceptors; Pain Measurement; Rats; Receptors, Adrenergic, alpha; Receptors, GABA-A; Valproic Acid	1988
The effects of centrally acting adrenergic agonists on temperature and on explorative and motor behaviour. Relation with effects on quasi-morphine withdrawal behaviour. European journal of pharmacology, 1985, Jan-08, Volume: 107, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Exploratory Behavior; Humans; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Valproic Acid	1985
Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature. Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate. Biochemical pharmacology, 1985, Nov-01, Volume: 34, Issue:21 Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Body Temperature; Ethanolamines; Exploratory Behavior; Glutamate Decarboxylase; Male; Morphine; Rats; Substance Withdrawal Syndrome; Valproic Acid	1985
Discriminative stimulus properties of valproic acid in the pigeon. Psychopharmacology, 1985, Volume: 87, Issue:4 Topics: Animals; Anticonvulsants; Columbidae; Dextroamphetamine; Discrimination Learning; Generalization, Psychological; Imipramine; Morphine; Pentylenetetrazole; Valproic Acid	1985
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: suppression by alpha 2-adrenoceptor stimulation. Psychopharmacology, 1983, Volume: 81, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Humans; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Valproic Acid	1983
GABA-opiates interactions in the activity of analgesics. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 265, Issue:1 Topics: Aminooxyacetic Acid; Analgesics, Opioid; Animals; Bicuculline; Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Male; Morphine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Structure-Activity Relationship; Valproic Acid	1983
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: involvement of amygdaloid and thalamic structures. Brain research, 1981, Dec-14, Volume: 229, Issue:1 Topics: Amygdala; Animals; Bicuculline; Caudate Nucleus; Hippocampus; Humans; Male; Morphine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Substance Withdrawal Syndrome; Substantia Nigra; Thalamic Nuclei; Valproic Acid	1981
A dual action of valproic acid upon morphine analgesia and morphine withdrawal. Pharmacology, 1983, Volume: 26, Issue:6 Topics: Analgesia; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Humans; Mice; Morphine; Naloxone; Substance Withdrawal Syndrome; Valproic Acid	1983
Quasi-morphine withdrawal behaviour: indication for a specific involvement of the GABA-ergic nerve terminal compartment. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Animals; gamma-Aminobutyric Acid; Humans; Male; Morphine; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Valproic Acid	1983
Behavioral interactions between opiate and antiepileptic drugs in the mouse. Neuropharmacology, 1981, Volume: 20, Issue:4 Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Enkephalins; Male; Mice; Morphine; Narcotics; Taurine; Time Factors; Trimethadione; Valproic Acid	1981
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: participation of the locus coeruleus system. Brain research, 1982, Sep-16, Volume: 247, Issue:2 Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Disease Models, Animal; Humans; Locus Coeruleus; Male; Morphine; Movement Disorders; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Valproic Acid	1982
Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases. Toxicology and applied pharmacology, 1982, Volume: 64, Issue:3 Topics: Animals; Chloramphenicol; Enzyme Induction; Glucuronates; Glucuronic Acid; Glucuronosyltransferase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Morphine; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Valproic Acid	1982
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice. Journal of pharmacological and toxicological methods, 1996, Volume: 35, Issue:1 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Ear; Electrodes; Electroshock; Ethosuximide; Injections, Intravenous; Male; Mice; Morphine; Phenobarbital; Phenytoin; Seizures; Valproic Acid	1996
Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behavioural brain research, 2004, Jul-09, Volume: 152, Issue:2 Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; GABA Agents; Male; Mice; Morphine; Motor Activity; Narcotics; Stereotyped Behavior; Time Factors; Valproic Acid	2004
Valproic acid sodium inhibits the morphine-induced conditioned place preference in the central nervous system of rats. Neuroscience letters, 2007, Oct-22, Volume: 426, Issue:3 Topics: Animals; Behavior, Animal; Brain; Conditioning, Classical; GABA Agents; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Narcotics; Rats; Rats, Wistar; Valproic Acid	2007
Valproate attenuates the development of morphine antinociceptive tolerance. Neuroscience letters, 2010, Nov-19, Volume: 485, Issue:2 Topics: Analgesics; Animals; Drug Tolerance; GABA Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Pain Measurement; Pain Threshold; Valproic Acid	2010
Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice. Neuroscience letters, 2011, Apr-25, Volume: 494, Issue:2 Topics: Acetylation; Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Histone Deacetylase Inhibitors; Histones; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Valproic Acid	2011
Vulnerability to opiate intake in maternally deprived rats: implication of MeCP2 and of histone acetylation. Addiction biology, 2015, Volume: 20, Issue:1 Topics: Acetylation; Analgesics, Opioid; Animals; Behavior, Animal; Epigenesis, Genetic; Gene-Environment Interaction; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Maternal Deprivation; Methyl-CpG-Binding Protein 2; Morphine; Nucleus Accumbens; Opioid-Related Disorders; Rats; Valproic Acid	2015
GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity. Molecular and cellular neurosciences, 2015, Volume: 65 Topics: Animals; Cell Line, Tumor; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HIV-1; Humans; Mice; Morphine; Neurons; Valproic Acid	2015
Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. Journal of pharmacological sciences, 2015, Volume: 128, Issue:4 Topics: Acetylation; Analgesia; Analgesics; Animals; Down-Regulation; Drug Resistance; Ganglia, Spinal; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Male; Mice, Inbred C57BL; Morphine; Neuralgia; Peripheral Nerve Injuries; Receptors, Opioid, mu; Valproic Acid	2015
Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls. Brain research bulletin, 2021, Volume: 174 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Female; Gene Expression; Genes, fos; Genes, Immediate-Early; Hippocampus; Male; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Social Behavior; Valproic Acid	2021