valproic acid and methotrexate

valproic acid has been researched along with methotrexate in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.22)	18.7374
1990's	4 (8.89)	18.2507
2000's	16 (35.56)	29.6817
2010's	20 (44.44)	24.3611
2020's	4 (8.89)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Endou, H; Hosoyamada, M; Kanai, Y; Sekine, T; Watanabe, N	1
Amano, O; Izeki, S; Kido, Y; Ogihara, T; Ono, A; Sai, Y; Satoh, E; Takanaga, H; Tamai, I; Tsuji, A; Yabuuchi, H	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Agarwal, S; Elmquist, WF; Li, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Elmazar, MM; Nau, H	1
Johnson, EM	1
Abe, T; Hori, S; Kawashima, H; Mori, T; Morikawa, N; Takeyama, M	1
Cameron, R; Feuer, G	1
Katada, S; Kobayashi, H; Sato, A; Sato, M	1
Hamada, N; Nagai, J; Ogawa, K; Takano, M; Yumoto, R	1
Beneyto, P; García-Aparicio, AM; Leal, MA; Platero, M	1
Das, CM; Gopalakrishnan, V; Prasad, P; Vasquez, H; Wolff, JE	1
Garlich, FM; Goldfarb, DS	1
Ahmad, T; Jena, GB; Khan, S; Parekh, CV; Shekh, K; Vikram, A; Yadav, L	1
Abdel-Rahman, MN; Kabel, AM	1
Amacher, DE; Chalasani, N	1
Davis, K; Fabian, E; Greenhaw, J; Groeters, S; Herold, M; Kamp, H; Looser, R; Marxfeld, H; Mattes, W; Mellert, W; Moeller, N; Montoya-Parra, G; Prokoudine, A; Strauss, V; van Ravenzwaay, B; Walk, T	1
Vinken, M	1
Guo, GL; Schumacher, JD	1
García-Nieto, AJV; Gómez-Arias, PJ	1
Cui, YX; Dong, WC; Feng, JY; Guo, JL; Jiang, Y; Wu, XK; Zhang, CX; Zhang, ZQ; Zhao, MQ	1
Badary, OA; El Said, HH; El-Khatib, AS; Elmazar, MM; Shouman, SA	1
Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z	1

Reviews

6 review(s) available for valproic acid and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The effect of drugs and toxins on the process of apoptosis. Drug metabolism and drug interactions, 2001, Volume: 18, Issue:1 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Glucocorticoids; Hepatocytes; Humans; Methotrexate; Toxins, Biological; Valproic Acid	2001
Have advances in extracorporeal removal techniques changed the indications for their use in poisonings? Advances in chronic kidney disease, 2011, Volume: 18, Issue:3 Topics: Carbamazepine; Hemodiafiltration; Hemodynamics; Hemoperfusion; Humans; Insulin; Membranes, Artificial; Methotrexate; Myoglobin; Peritoneal Dialysis; Poisoning; Ultrafiltration; Valproic Acid; Vancomycin	2011
Drug-induced hepatic steatosis. Seminars in liver disease, 2014, Volume: 34, Issue:2 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Anti-Retroviral Agents; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Hormonal; Drug Evaluation, Preclinical; Fatty Liver; Humans; Immunosuppressive Agents; Lysosomal Storage Diseases; Methotrexate; Mitochondria, Liver; Phospholipids; Tamoxifen; Valproic Acid	2014
Adverse Outcome Pathways and Drug-Induced Liver Injury Testing. Chemical research in toxicology, 2015, Jul-20, Volume: 28, Issue:7 Topics: Bosentan; Chemical and Drug Induced Liver Injury; Cholestasis; Fatty Liver; Humans; Liver Cirrhosis; Methotrexate; Quantitative Structure-Activity Relationship; Sulfonamides; Valproic Acid	2015
Mechanistic review of drug-induced steatohepatitis. Toxicology and applied pharmacology, 2015, Nov-15, Volume: 289, Issue:1 Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid	2015

Other Studies

39 other study(ies) available for valproic acid and methotrexate

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Expression cloning and characterization of a novel multispecific organic anion transporter. The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Carrier Proteins; Cloning, Molecular; Dicarboxylic Acid Transporters; Gene Expression; Glycosylation; In Situ Hybridization; Kidney; Kinetics; Membrane Proteins; Molecular Sequence Data; Organic Anion Transporters, Sodium-Dependent; p-Aminohippuric Acid; Rats; RNA, Messenger; Symporters; Xenopus laevis	1997
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:10 Topics: Amino Acid Sequence; Animals; Benzoic Acid; Biological Transport; Carboxylic Acids; Carrier Proteins; Cell Line; Digestive System; Hydrogen-Ion Concentration; Immunohistochemistry; Intestinal Absorption; Lactic Acid; Molecular Sequence Data; Monocarboxylic Acid Transporters; Rats; Tissue Distribution; Transfection	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Brain efflux index to investigate the influence of active efflux on brain distribution of pemetrexed and methotrexate. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Folic Acid Antagonists; Glutamates; Guanine; Half-Life; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Pemetrexed; Penicillin G; Probenecid	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. Teratogenesis, carcinogenesis, and mutagenesis, 1992, Volume: 12, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Encephalocele; Female; Folic Acid; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Valproic Acid	1992
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data. Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:3 Pt 2 Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratolytic Agents; Methotrexate; Pregnancy; Risk Assessment; Teratogens; Thalidomide; Tretinoin; Valproic Acid	1997
Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Glioblastoma; Humans; Methotrexate; Nimustine; Valproic Acid	2000
[A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:1 Topics: Aged; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Female; Humans; Methotrexate; Polymyalgia Rheumatica; Prednisolone; Valproic Acid	2004
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy research, 2006, Volume: 71, Issue:1 Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Glutathione; Indomethacin; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Transport Vesicles; Valproic Acid	2006
[Behçet's disease in treatment with cyclosporine and seizures: diagnostic dilemma]. Revista clinica espanola, 2007, Volume: 207, Issue:8 Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Behcet Syndrome; Cyclosporins; Electroretinography; Emergencies; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Intraocular Pressure; Methotrexate; Seizures; Time Factors; Valproic Acid	2007
Histone acetylation resulting in resistance to methotrexate in choroid plexus cells. Journal of neuro-oncology, 2009, Volume: 91, Issue:3 Topics: Acetylation; Animals; Antigens, Viral, Tumor; Apoptosis; Benzamides; Carcinoma; Cell Line, Transformed; Cell Line, Tumor; Choroid Plexus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Inhibitory Concentration 50; Methotrexate; Mice; Pyridines; Tetrazolium Salts; Thiazoles; Valproic Acid	2009
Pretreatment with valproic acid, a histone deacetylase inhibitor, enhances the sensitivity of the peripheral blood micronucleus assay in rodents. Mutation research, 2013, Feb-18, Volume: 751, Issue:1 Topics: Animals; Cyclophosphamide; Erythrocytes; Histone Deacetylase Inhibitors; Male; Methotrexate; Mice; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Reticulocytes; Sensitivity and Specificity; Valproic Acid; Zidovudine	2013
Comparative study between the effect of methotrexate and valproic acid on solid Ehrlich tumour. Journal of the Egyptian National Cancer Institute, 2012, Volume: 24, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Ehrlich Tumor; Catalase; Cholesterol; Drug Screening Assays, Antitumor; Glutathione Peroxidase; Malondialdehyde; Methotrexate; Mice; Neoplasm Transplantation; Tumor Burden; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Valproic Acid	2012
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology letters, 2014, Nov-04, Volume: 230, Issue:3 Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Flutamide; Lamivudine; Liver; Male; Mannitol; Metabolomics; Methotrexate; Neomycin; Oxidative Stress; Phenytoin; Piperazines; Propylthiouracil; Rats; Rats, Wistar; Streptomycin; Triazoles; Valproic Acid; Vancomycin; Zidovudine	2014
Rupioid psoriasis on the hands. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020, Nov-09, Volume: 192, Issue:45 Topics: Adult; Antimanic Agents; Dermatologic Agents; Hand; Humans; Male; Methotrexate; Psoriasis; Valproic Acid	2020
A simple and accurate HFCF-UF method for the analysis of homocysteine, cysteine, cysteinyl-glycine, and glutathione in human blood. Analytical and bioanalytical chemistry, 2021, Volume: 413, Issue:25 Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme Inhibitors; Freezing; Glutathione; Homocysteine; Humans; Limit of Detection; Methotrexate; Molecular Structure; Tandem Mass Spectrometry; Temperature; Ultrafiltration; Valproic Acid; Vancomycin	2021
Enhanced antitumor activity of combined methotrexate and histone deacetylase inhibitor valproic acid on mammary cancer in vitro and in vivo. Canadian journal of physiology and pharmacology, 2022, Sep-01, Volume: 100, Issue:9 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Histone Deacetylase Inhibitors; Methotrexate; Mice; Valproic Acid	2022
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. Neurochemical research, 2022, Volume: 47, Issue:12 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Female; Fluorouracil; Hydroxyurea; Methotrexate; Mice; Molecular Docking Simulation; Network Pharmacology; Neural Tube Defects; Phosphatidylinositol 3-Kinases; Pregnancy; Tretinoin; Valproic Acid	2022