valproic acid has been researched along with methionine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Klein, NW; Nosel, PG | 1 |
| Ehlers, K; Elmazar, MM; Nau, H | 1 |
| Abbott, FS; Huang, HS; Jurima-Romet, M; Tang, W; Whitehouse, LW | 1 |
| Alonso, E; Martín-Rodríguez, JC; Pérez-Miguelsanz, J; Puerta, J; Ubeda, N; Varela-Moreiras, G | 1 |
| Hishida, R; Nau, H | 1 |
| Achón, M; Alonso-Aperte, E; Pérez-Miguelsanz, J; Ubeda, N; Varela-Moreiras, G | 1 |
| Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Frossard, JL; Goodman, K; Hadengue, A; Jordan, M; Marinescu, O; Negro, F; Rubbia-Brandt, L; Spahr, L | 1 |
| Alonso-Aperte, E; Ubeda, N; Varela-Moreiras, G | 1 |
| Carboni, G; Costa, E; Grayson, DR; Guidotti, A; Mitchell, CP; Ruzicka, WB; Sharma, R; Sugaya, I; Tremolizzo, L; Tueting, P | 1 |
| Costa, E; Grayson, DR; Guidotti, A | 1 |
| Agis-Balboa, RC; Costa, E; Doueiri, MS; Guidotti, A; Pinna, G | 1 |
| Costa, E; Davis, J; Dong, E; Doueiri, MS; Grayson, DR; Guidotti, A; Pinna, G; Rodriguez-Menendez, V; Tremolizzo, L; Tueting, P | 1 |
| Tremolizzo, L | 1 |
| Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Costa, E; Davis, JM; Guidotti, A; Kadriu, B; Pibiri, F; Tueting, P; Veldic, M | 1 |
| Di Renzo, F; Giavini, E; Menegola, E | 1 |
| Fujii, M; Matsunaga, T; Miya, F; Mutai, H; Tsunoda, T | 1 |
| Becker, M; Ergaz, Z; Ornoy, A; Weinstein-Fudim, L | 1 |
4 review(s) available for valproic acid and methionine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
Topics: Animals; Brain; Cell Adhesion Molecules, Neuronal; Epigenesis, Genetic; Extracellular Matrix Proteins; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Humans; Methionine; Models, Neurological; Nerve Tissue Proteins; Neurons; Reelin Protein; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2003 |
Brain neurosteroids in gender-related aggression induced by social isolation.
Topics: Aggression; Animals; Female; GABA Agents; Gonadal Steroid Hormones; Male; Methionine; Mice; Neurotransmitter Agents; Pregnanolone; Reelin Protein; Sex Characteristics; Social Isolation; Steroids; Valproic Acid | 2004 |
Topics: Animals; Autism Spectrum Disorder; Epigenesis, Genetic; Female; Humans; Methionine; Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid | 2020 |
17 other study(ies) available for valproic acid and methionine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations.
Topics: Animals; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Resorption; Maternal-Fetal Exchange; Methionine; Neural Tube Defects; Pregnancy; Rats; Valproic Acid | 1992 |
Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Embryonic and Fetal Development; Female; Incidence; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methionine; Mice; Neural Tube Defects; Spinal Dysraphism; Valproic Acid | 1996 |
Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
Topics: Analysis of Variance; Animals; Anticonvulsants; Ascorbic Acid; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Glutathione; Homeostasis; L-Lactate Dehydrogenase; Liver; Male; Mass Spectrometry; Methionine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Valproic Acid; Vitamin E | 1996 |
Valproate-induced developmental modifications maybe partially prevented by coadministration of folinic acid and S-adenosylmethionine.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Female; Fetus; Leucovorin; Liver; Methionine; Methylation; Neural Tube Defects; Pregnancy; Rats; Rats, Wistar; S-Adenosylmethionine; Valproic Acid | 1996 |
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1998 |
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation.
Topics: Analysis of Variance; Animals; Female; Folic Acid; Gestational Age; Homocysteine; Methionine; Methylation; Rats; Rats, Wistar; Valproic Acid | 1999 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
Acute valproate-associated microvesicular steatosis: could the [13C]methionine breath test be useful to assess liver mitochondrial function?
Topics: Adult; Antimanic Agents; Breath Tests; Drug Overdose; Female; Hepatocytes; Humans; Liver Failure; Methionine; Mitochondria, Liver; Valproic Acid | 2001 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.
Topics: Acetylation; Animals; Cell Adhesion Molecules, Neuronal; CpG Islands; Disease Models, Animal; Disease Susceptibility; DNA Methylation; Down-Regulation; Extracellular Matrix Proteins; Glutamate Decarboxylase; Histones; Isoenzymes; Methionine; Mice; Mice, Neurologic Mutants; Nerve Tissue Proteins; Promoter Regions, Genetic; Reelin Protein; Reflex, Startle; RNA, Messenger; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2002 |
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blotting, Western; Cell Adhesion Molecules, Neuronal; Chromosome Mapping; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Extracellular Matrix Proteins; Frontal Lobe; GABA Modulators; Histones; Imidazoles; Immunohistochemistry; Interpersonal Relations; Male; Methionine; Methylation; Mice; Motor Activity; Nerve Tissue Proteins; Neural Inhibition; Promoter Regions, Genetic; Reelin Protein; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Schizophrenia; Serine Endopeptidases; Time Factors; Valproic Acid | 2005 |
[Epigenetic model in the pharmacologic modulation of vulnerability to schizophrenia].
Topics: Anticonvulsants; Brain; Cell Adhesion Molecules, Neuronal; Down-Regulation; Epigenesis, Genetic; Extracellular Matrix Proteins; Glutamate Decarboxylase; Humans; Injections, Subcutaneous; Interpersonal Relations; Methionine; Nerve Tissue Proteins; Reelin Protein; RNA, Messenger; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2007 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Liver; Male; Methionine; Oxidation-Reduction; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Riboflavin; Valproic Acid; Vitamin B Deficiency | 2008 |
L-methionine decreases dendritic spine density in mouse frontal cortex.
Topics: Animals; Anticonvulsants; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Shape; Dendritic Spines; Disease Models, Animal; Down-Regulation; Drug Interactions; Extracellular Matrix Proteins; Frontal Lobe; GABA Agents; Male; Methionine; Methylation; Mice; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Reelin Protein; Schizophrenia; Serine Endopeptidases; Synapses; Valproic Acid | 2010 |
Methionine pretreatment enhances the effects of valproate on axial development in a CD1 mouse model.
Topics: Acetylation; Animals; Blotting, Western; Disease Models, Animal; Embryonic Development; Female; Fetus; Histones; Methionine; Mice; Pregnancy; Valproic Acid | 2013 |
Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.
Topics: Animals; Catechin; Cation Transport Proteins; Cochlea; Down-Regulation; Epigenesis, Genetic; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Immunohistochemistry; Methionine; Mice; Mice, Inbred DBA; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Organ of Corti; Real-Time Polymerase Chain Reaction; Spiral Ganglion; Up-Regulation; Valproic Acid | 2015 |