valproic acid and meropenem

valproic acid has been researched along with meropenem in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.04)	18.2507
2000's	20 (40.82)	29.6817
2010's	21 (42.86)	24.3611
2020's	7 (14.29)	2.80

Authors

Authors	Studies
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Camu, F; Cornelis, PJ; De Turck, BJ; Diltoer, MW; Huyghens, LP; Maes, V; Spapen, HD	1
Ichimura, F; Ishizaki, J; Iwashita, S; Kawahara, M; Kimura, K; Kubota, A; Matsushita, R; Miyamoto, K; Sasaki, Y; Yokogawa, K	1
Nicolas, JM; Pérez Plasencia, A; Soy, D	1
Nacarkucuk, E; Okan, M; Saglam, H	1
Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F	1
Parmeggiani, A; Riva, R; Santucci, M	1
Clause, D; Decleire, PY; Hantson, P; Soyer, A; Vanbinst, R	1
Balcells Ramírez, J; Cabañas Poy, MJ; Clemente Bautista, S; Hidalgo Albert, E; Oliveras Arenas, M; Padullés Zamora, N; Sala Piñol, F	1
Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M	1
Carcas, A; Fudio, S; Ortega, R; Piñana, E	1
Casteels, M; De Troy, E; Meersseman, W; Spriet, I; Willems, L; Wilmer, A	1
Goyens, J; Meersseman, W; Spriet, I; Van Paesschen, W; Willems, L; Wilmer, A	1
Joo, JY; Kim, JH; Kwon, OH; Lee, SG	1
Joyanes Abancens, B; San Antonio Arce, V	1
Gu, J; Huang, Y	1
Borobia, AM; Carcas Sansuán, AJ; Fudio, S	1
Adam, M; Haroutiunian, S; Hoffman, A; Rabinovich, B; Ratz, Y	1
Cachá Acosta, A; Esteban Calvo, C; Ibáñez Ruiz, C; López-Oliva, AG	1
Fernández de la Puebla Giménez, RÁ; Fernández García, MI; García Olid, B; Torres Degayón, V	1
Alvarez Díaz, AM; Bermejo Vicedo, T; Delgado Silveira, E; Pérez Menéndez-Conde, C; Vélez Díaz-Pallarés, M; Vicente Oliveros, N	1
Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M	1
Izumi, T; Kobayashi, N; Nakai, D; Okazaki, O; Suzuki, E; Yamamura, N	1
Spriet, I; Willems, L	1
Chusri, S; Patharachayakul, S; Suntimaleeworakul, W	1
González, C; Villena, R	1
Kim, DH; Yoon, H	1
Berardi, D; Bruetman, JE; Clemente, R; Finn, BC; Young, P	1
Fusegawa, K; Goda, R; Ikenaga, H; Izumi, T; Kobayashi, N; Kuga, H; Nakai, D; Suzuki, E	1
Estaún-Martínez, C; Ojeda Burgos, G; Sánchez-Yáñez, E	1
Eap, CB; Gründer, G; Kuzin, M; Paulzen, M	1
Hsiao, FY; Pai, TY; Shen, LJ; Wu, CC; Wu, FL	1
Chen, XP; Chen, Y; Du, C; Fan, SS; Peng, ZF; Wen, ZP; Xiao, J; Xie, YY; Yin, T; Zhang, W; Zhou, BT	1
Chiba, K; Goda, R; Koyama, K; Kuga, H; Nakai, D; Suzuki, E	1
Biggs, AD; Dudley, SW; Erstad, BL; French, RNE; Huckleberry, YC; Khobrani, MA; Kopp, BJ; Shirazi, FM	1
Beres, K; Dreucean, D; Gravino, D; McNierney-Moore, A	1
Priano, J; Smith, TL; Thomas, C	1
Lolas, R; Muñoz-Pichuante, D; Villa-Zapata, L	1
Akella, J; Sanivarapu, R; Sharma, R	1
Clark, K; Cunningham, D; Lord, K	1
Bruni-Montero, MÁ; Canales-Siguero, D; Caro-Telle, JM; Ferrari-Piquero, JM; Hernández-Ramos, JA	1
Kramers, K; Natsch, S; Smolders, EJ; Ter Heine, R	1
Huang, J; Jin, Y; Pei, Y; Sun, Q	1

Reviews

2 review(s) available for valproic acid and meropenem

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Treatment of valproic acid overdose with meropenem in an epileptic patient. The American journal of emergency medicine, 2022, Volume: 53 Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Overdose; Epilepsy; Female; Humans; Meropenem; Valproic Acid	2022

Other Studies

47 other study(ies) available for valproic acid and meropenem

Article	Year
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:4 Topics: Aged; Amikacin; Anti-Bacterial Agents; Anticonvulsants; Drug Antagonism; Female; Humans; Meropenem; Middle Aged; Thienamycins; Valproic Acid	1998
Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharmaceutical research, 2001, Volume: 18, Issue:9 Topics: Animals; Anticonvulsants; Area Under Curve; Bile; Biotransformation; Drug Interactions; Glucuronides; Male; Meropenem; Rabbits; Thienamycins; Tissue Distribution; Valproic Acid	2001
[Pharmacokinetic interaction between valproic acid and meropenem]. Medicina clinica, 2004, Jun-05, Volume: 123, Issue:1 Topics: Adolescent; Drug Interactions; GABA Agents; Humans; Male; Meropenem; Thienamycins; Valproic Acid	2004
Meropenem decreases serum level of valproic acid. Pediatric neurology, 2004, Volume: 31, Issue:3 Topics: Adolescent; Drug Interactions; Drug Therapy, Combination; Female; Humans; Infant; Male; Meropenem; Thienamycins; Valproic Acid	2004
Acute seizures due to a probable interaction between valproic acid and meropenem. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:3 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Infusions, Intravenous; Meropenem; Seizures; Thienamycins; Valproic Acid	2005
Seizure worsening caused by decreased serum valproate during meropenem therapy. Journal of child neurology, 2005, Volume: 20, Issue:5 Topics: Anti-Bacterial Agents; Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Meropenem; Neuroaxonal Dystrophies; Thienamycins; Valproic Acid	2005
Pharmacokinetic interaction between valproic acid and meropenem. Intensive care medicine, 2005, Volume: 31, Issue:9 Topics: Adult; Aged; Anticonvulsants; Drug Interactions; Humans; Male; Meropenem; Seizures; Sepsis; Thienamycins; Valproic Acid	2005
[Pharmacokinetic interaction between valproic acid and meropenem]. Anales de pediatria (Barcelona, Spain : 2003), 2006, Volume: 64, Issue:1 Topics: Anti-Bacterial Agents; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Female; Humans; Male; Meropenem; Thienamycins; Valproic Acid	2006
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics. Toxicology, 2006, May-01, Volume: 222, Issue:1-2 Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; Drug Interactions; Electroencephalography; Injections, Intravenous; Injections, Intraventricular; Male; Meropenem; Mice; Mice, Inbred ICR; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Thienamycins; Valproic Acid	2006
Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:4 Topics: Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Meropenem; Middle Aged; Pneumonia; Thienamycins; Valproic Acid	2006
Meropenem -valproic acid interaction in patients with cefepime-associated status epilepticus. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2007, Jan-01, Volume: 64, Issue:1 Topics: Anti-Bacterial Agents; Anticonvulsants; Cefixime; Ceftazidime; Drug Interactions; Female; Humans; Male; Meropenem; Middle Aged; Status Epilepticus; Thienamycins; Valproic Acid	2007
Interaction between valproate and meropenem: a retrospective study. The Annals of pharmacotherapy, 2007, Volume: 41, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Contraindications; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Valproic Acid	2007
[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics]. The Korean journal of laboratory medicine, 2007, Volume: 27, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Thienamycins; Valproic Acid	2007
[Meropenem and valproic acid. An interaction to remember]. Anales de pediatria (Barcelona, Spain : 2003), 2009, Volume: 70, Issue:2 Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Infant; Meropenem; Thienamycins; Valproic Acid	2009
Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient. The American journal of geriatric pharmacotherapy, 2009, Volume: 7, Issue:1 Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Humans; Male; Meropenem; Pneumonia; Seizures; Thienamycins; Treatment Outcome; Valproic Acid	2009
[Valproate-meropenem co-administration, an example of information shortcomings in relevant drug interactions]. Medicina clinica, 2009, May-30, Volume: 132, Issue:20 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Female; Humans; Infant; Male; Meropenem; Middle Aged; Thienamycins; Valproic Acid; Young Adult	2009
Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study. Journal of clinical pharmacology, 2009, Volume: 49, Issue:11 Topics: Anticonvulsants; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Time Factors; Valproic Acid	2009
[Valproate-meropenem interaction as an example of information shortcomings in relevant drug interactions]. Medicina clinica, 2010, Nov-06, Volume: 135, Issue:13 Topics: Adverse Drug Reaction Reporting Systems; Drug Interactions; Drug Labeling; Humans; Meropenem; Product Surveillance, Postmarketing; Spain; Thienamycins; Valproic Acid	2010
[Meropenem decreases valproate plasmatic concentrations]. Medicina clinica, 2011, Jun-11, Volume: 137, Issue:1 Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Humans; Male; Meropenem; Middle Aged; Thienamycins; Valproic Acid	2011
[Analysis of the valproic acid-meropenem interaction in hospitalised patients]. Neurologia (Barcelona, Spain), 2012, Volume: 27, Issue:1 Topics: Anti-Bacterial Agents; Anticonvulsants; Databases, Factual; Drug Interactions; Drug Monitoring; Electronic Health Records; Female; Hospitalization; Humans; Male; Meropenem; Pharmacists; Prospective Studies; Retrospective Studies; Thienamycins; Valproic Acid	2012
Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:8 Topics: Administration, Oral; Aged; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Biological Availability; Brain Ischemia; Critical Care; Drug Interactions; Enteral Nutrition; Epilepsy; Female; Humans; Intensive Care Units; Levetiracetam; Male; Meropenem; Middle Aged; Piracetam; Prospective Studies; Seizures; Subarachnoid Hemorrhage; Thienamycins; Valproic Acid	2011
Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid. Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:11 Topics: Animals; Carbapenems; Cytosol; Dialysis; Humans; Hydrolysis; Isoflurophate; Kinetics; Liver; Meropenem; Peptide Hydrolases; Sus scrofa; Thienamycins; Time Factors; Valproic Acid	2011
No interaction between valproate and meropenem in a cirrhotic patient. The Annals of pharmacotherapy, 2011, Volume: 45, Issue:9 Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Enterobacteriaceae Infections; Epilepsy, Tonic-Clonic; Female; Humans; Liver Cirrhosis; Meropenem; Middle Aged; Pneumonia, Bacterial; Thienamycins; Valproic Acid	2011
Drug interaction between valproic acid and meropenem: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2012, Volume: 95, Issue:2 Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Fructose; Humans; Male; Meropenem; Thienamycins; Topiramate; Valproic Acid	2012
[Pharmacological interaction between meropenem and valproic acid: a report of two cases]. Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2012, Volume: 29, Issue:3 Topics: Anticonvulsants; beta-Lactamase Inhibitors; Child, Preschool; Drug Interactions; Epilepsy; Fatal Outcome; Female; Humans; Infant; Meropenem; Seizures; Thienamycins; Valproic Acid	2012
Unusual drug reaction between valproate sodium and meropenem. International journal of clinical pharmacy, 2013, Volume: 35, Issue:3 Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; beta-Lactams; Drug Interactions; Drug Monitoring; Epilepsy; Ertapenem; Humans; Male; Meropenem; Thienamycins; Valproic Acid	2013
[Not to forget interaction between meropenem and valproic acid]. Revista medica de Chile, 2014, Volume: 142, Issue:3 Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Female; Humans; Meropenem; Seizures; Thienamycins; Valproic Acid	2014
In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs. Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:2 Topics: Administration, Intravenous; Animals; Carbapenems; Cytosol; Dogs; Drug Interactions; Enzyme Inhibitors; Hydrolysis; Kidney; Liver; Male; Meropenem; Peptide Hydrolases; Protease Inhibitors; Thienamycins; Valproic Acid	2016
[Meropenem and valproic acid: A clinically relevant drug-drug interaction]. Enfermedades infecciosas y microbiologia clinica, 2016, Volume: 34, Issue:8 Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Fructose; Humans; Meropenem; Peritonitis; Postoperative Complications; Thienamycins; Topiramate; Valproic Acid	2016
Pharmacokinetic Interaction Between Valproic Acid, Meropenem, and Risperidone. Journal of clinical psychopharmacology, 2016, Volume: 36, Issue:1 Topics: Adult; Anti-Bacterial Agents; Drug Interactions; Humans; Male; Meropenem; Risperidone; Thienamycins; Valproic Acid	2016
The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations. Therapeutic drug monitoring, 2016, Volume: 38, Issue:5 Topics: Anti-Bacterial Agents; Anticonvulsants; beta-Lactams; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Interactions; Ertapenem; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Valproic Acid	2016
Drug-drug interaction between valproic acid and meropenem: a retrospective analysis of electronic medical records from neurosurgery inpatients. Journal of clinical pharmacy and therapeutics, 2017, Volume: 42, Issue:2 Topics: Adult; Anti-Bacterial Agents; Drug Interactions; Drug Monitoring; Electronic Health Records; Humans; Inpatients; Meropenem; Middle Aged; Neurosurgical Procedures; Retrospective Studies; Thienamycins; Valproic Acid	2017
Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics. European journal of drug metabolism and pharmacokinetics, 2017, Volume: 42, Issue:6 Topics: Animals; Carbapenems; Drug Interactions; Humans; Liver; Meropenem; Mice; Peptide Hydrolases; Thienamycins; Transplantation Chimera; Valproic Acid	2017
Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report. Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:5 Topics: Anticonvulsants; Carbapenems; Drug Interactions; Humans; Male; Meropenem; Middle Aged; Valproic Acid	2018
Use of meropenem to treat valproic acid overdose. The American journal of emergency medicine, 2019, Volume: 37, Issue:11 Topics: Adult; Anti-Bacterial Agents; Antimanic Agents; Drug Overdose; Female; Humans; Meropenem; Valproic Acid	2019
Meropenem as an antidote for intentional valproic acid overdose. The American journal of emergency medicine, 2020, Volume: 38, Issue:3 Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Antidotes; Drug Overdose; Female; Humans; Meropenem; Valproic Acid	2020
Meropenem for management of valproic acid overdose: a case report. Drug metabolism and personalized therapy, 2020, 06-30, Volume: 35, Issue:2 Topics: Administration, Oral; Adult; Anticonvulsants; Drug Overdose; Emergency Service, Hospital; Female; Humans; Mental Disorders; Meropenem; Valproic Acid	2020
Thinking out of the box: management of valproic acid toxicity with carbapenems. BMJ case reports, 2021, Mar-10, Volume: 14, Issue:3 Topics: Adult; Anticonvulsants; Carbapenems; Carnitine; Epilepsy; Female; Humans; Meropenem; Valproic Acid	2021
Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2021, 09-28, Volume: 45, Issue:6 Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Ertapenem; Humans; Male; Meropenem; Pharmaceutical Preparations; Retrospective Studies; Valproic Acid	2021
Meropenem to Treat Valproic Acid Intoxication. Therapeutic drug monitoring, 2022, 06-01, Volume: 44, Issue:3 Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Humans; Meropenem; Valproic Acid	2022
A High-Performance Liquid Chromatography-Mass Spectrometry Method for Simultaneous Determination of Vancomycin, Meropenem, and Valproate in Patients with Post-Craniotomy Infection. Molecules (Basel, Switzerland), 2023, Mar-07, Volume: 28, Issue:6 Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Limit of Detection; Meropenem; Reproducibility of Results; Tandem Mass Spectrometry; Valproic Acid; Vancomycin	2023