valproic acid has been researched along with lysine in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Bianchi, A; Brunet, C; Luyckx, M; Paluszezak, D | 1 |
| Bock, I; Melegh, B; Pap, M; Rebouche, CJ | 1 |
| Cartigny, B; Imbenotte, M; Lhermitte, M; Vermeersch, G | 1 |
| Diener, HC; Leniger, T; Limmroth, V; Pageler, L; Stude, P | 1 |
| Canonico, PL; Condorelli, F; Genazzani, AA; Gnemmi, I; Vallario, A | 1 |
| Costa, E; Dong, E; Grayson, DR; Guidotti, A; Nelson, M | 1 |
| Füllgrabe, J; Hajji, N; Hermanson, O; Joseph, B; Vlachos, P; Wallenborg, K | 1 |
| Chen, X; Radany, EH; Wong, JY; Wong, P | 1 |
| Costa-Borges, N; Gonzalez, S; Ibáñez, E; Santaló, J | 1 |
| Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Yang, D; Zhang, X | 1 |
| Capogrossi, MC; Castellano, S; Colussi, C; Farsetti, A; Gaetano, C; Illi, B; Mai, A; Mattiussi, S; Rosati, J; Sbardella, G; Scopece, A; Spallotta, F; Vitale, S | 1 |
| Chen, LH; Cheng, LY; Cherng, CG; Kao, GS; Su, CC; Tzeng, WY; Wang, CY; Yu, L | 1 |
| Barbetti, V; Cheloni, G; Dello Sbarba, P; Fabiani, E; Gozzini, A; Marzi, I; Rovida, E; Santini, V | 1 |
| An, L; Jaime-Frias, R; Kadiyala, V; Mathieu, W; Patrick, NM; Pookhao, N; Smith, CL | 1 |
| Cadeiras, M; Deng, M; Fang, C; Kim, AK; Liem, DA; Lu, H; Ping, P; Scruggs, SB; Wang, D; Yang, P; Yu, H; Zong, NC | 1 |
| Alsarraf, O; Chou, CJ; Crosson, CE; Dahrouj, M; Fan, J; Menick, DR | 1 |
| Ng, YK; Ong, WY; Tan, CS | 1 |
| Cheng, Z; Hao, Y; Liu, H; Liu, N; Liu, X; Peng, X; Qi, W; Sun, Z; Wang, F; Wu, Q; Xu, L; Yan, J; Zheng, N; Zhu, J; Zhu, X | 1 |
| Benda, A; Kostrouchová, M; Kostrouchová, V; Mandys, V; Yilma, P | 1 |
| de Campos Vidal, B; Mello, MLS; Rocha, MA | 1 |
1 trial(s) available for valproic acid and lysine
| Article | Year |
|---|---|
Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks.
Topics: Acute Disease; Analgesics; Aspirin; Double-Blind Method; GABA Agents; Humans; Infusions, Intravenous; Lysine; Migraine Disorders; Treatment Outcome; Valproic Acid | 2005 |
21 other study(ies) available for valproic acid and lysine
| Article | Year |
|---|---|
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Comparison of the biological activity of sodium valproate and L-lysine valproate on brain GABA levels by (3H) muscimol radioreceptor assay.
Topics: Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Lysine; Male; Mice; Muscimol; Radioligand Assay; Rats; Rats, Inbred Strains; Valproic Acid | 1988 |
Relationship of carnitine and carnitine precursors lysine, epsilon-N-trimethyllysine, and gamma-butyrobetaine in drug-induced carnitine depletion.
Topics: Adolescent; Bacteriuria; Betaine; Carnitine; Child; Child, Preschool; Creatinine; Epilepsy; Female; Humans; Lysine; Male; Pivampicillin; Urinary Tract Infections; Valproic Acid | 1993 |
[Identification and quantification of exogenous metabolites in biological liquids with new development in NMR spectroscopy in one and two dimensions].
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Antimalarials; Aspirin; Chloroquine; Female; Humans; Lysine; Magnetic Resonance Spectroscopy; Male; Poisoning; Reproducibility of Results; Valproic Acid | 1999 |
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells.
Topics: Acetylation; Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Butyrates; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Valproic Acid | 2008 |
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.
Topics: Acetylation; Animals; Benzodiazepines; Brain; Cell Adhesion Molecules, Neuronal; Clozapine; DNA Methylation; Extracellular Matrix Proteins; Glutamate Decarboxylase; Haloperidol; Histones; Lysine; Male; Mice; Nerve Tissue Proteins; Olanzapine; Promoter Regions, Genetic; Reelin Protein; Serine Endopeptidases; Sulpiride; Valproic Acid | 2008 |
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
Topics: Acetylation; Animals; Cell Death; Cell Line, Tumor; DNA Damage; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Male; Neoplasms; Sirtuin 1; Topoisomerase II Inhibitors; Valproic Acid | 2010 |
Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis.
Topics: Acetylation; Apoptosis; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Lysine; Male; Membrane Potential, Mitochondrial; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53; Valproic Acid | 2011 |
Effect of the enucleation procedure on the reprogramming potential and developmental capacity of mouse cloned embryos treated with valproic acid.
Topics: Acetylation; Analysis of Variance; Animals; Birth Weight; Blastocyst; Cell Line; Cellular Reprogramming; Chi-Square Distribution; Chromatin Assembly and Disassembly; Clone Cells; Embryo Culture Techniques; Embryo Implantation; Embryo Transfer; Embryo, Mammalian; Embryonic Development; Female; Fetal Death; Gene Expression Regulation, Developmental; Gestational Age; Histone Deacetylase Inhibitors; Histones; Live Birth; Lysine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nuclear Transfer Techniques; Pregnancy; Reproductive Techniques, Assisted; Valproic Acid | 2011 |
Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons.
Topics: Animals; Astrocytes; Cerebral Cortex; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation; Hippocampus; Histone Deacetylases; Histones; Hypoxia; Lysine; Mice; Neprilysin; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering; Valproic Acid | 2011 |
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins.
Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Subcutaneous; Lysine; Male; Models, Animal; Muscle Contraction; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroglycerin; p300-CBP Transcription Factors; Pyridines; Rats; Valproic Acid; Vasodilation | 2012 |
Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female rats.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Azacitidine; Behavior, Animal; Cerebral Cortex; Conditioning, Psychological; Corticosterone; Cues; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Down-Regulation; Estradiol; Fear; Female; Histone Deacetylase Inhibitors; Histones; Light; Lysine; Maternal Deprivation; Methylation; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Stress, Psychological; Valproic Acid | 2012 |
Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells.
Topics: Acetylation; Apoptosis; Cell Differentiation; Core Binding Factor Alpha 2 Subunit; Gene Expression Regulation, Leukemic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Lysine; Proto-Oncogene Proteins; RUNX1 Translocation Partner 1 Protein; Time Factors; Transcription Factors; Valproic Acid; Vorinostat | 2013 |
Class I lysine deacetylases facilitate glucocorticoid-induced transcription.
Topics: Acetylation; Amidohydrolases; Animals; Cell Line, Tumor; Dexamethasone; Enzyme Inhibitors; Glucocorticoids; Histones; HSP90 Heat-Shock Proteins; Hydroxamic Acids; Lysine; Mice; Peptides, Cyclic; Protein Binding; Receptors, Glucocorticoid; Transcription, Genetic; Transcriptional Activation; Valproic Acid | 2013 |
Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human.
Topics: Acetylation; Animals; Chromatography, Liquid; Gene Expression Regulation; Heart Failure; Heart Transplantation; Heart Ventricles; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lysine; Male; Mice; Myocardial Reperfusion Injury; Myocardium; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Tandem Mass Spectrometry; Valproic Acid; Vorinostat | 2013 |
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Topics: Acetylation; Animals; Blotting, Western; Caspase 3; Cell Survival; Electroretinography; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Lysine; Male; Neuroprotective Agents; Rats, Inbred BN; Reperfusion Injury; Retinal Degeneration; Retinal Neurons; Valproic Acid | 2014 |
Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells.
Topics: Anacardic Acids; Anilides; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Deoxyadenosines; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; L-Lactate Dehydrogenase; Lysine; Neuroblastoma; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thionucleosides; Valproic Acid | 2016 |
Quantitative Analysis of Global Proteome and Lysine Acetylome Reveal the Differential Impacts of VPA and SAHA on HL60 Cells.
Topics: Acetylation; Amino Acid Motifs; Amino Acid Sequence; Cluster Analysis; Computational Biology; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Lysine; Position-Specific Scoring Matrices; Protein Interaction Mapping; Protein Interaction Maps; Proteome; Proteomics; Valproic Acid; Vorinostat | 2016 |
Valproic Acid Decreases the Nuclear Localization of MDT-28, the Nematode Orthologue of MED28.
Topics: Acetylation; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Nucleus; Computational Biology; Densitometry; Green Fluorescent Proteins; Humans; Larva; Lysine; Mediator Complex; Nuclear Proteins; Protein Transport; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Valproic Acid | 2018 |
Sodium Valproate Modulates the Methylation Status of Lysine Residues 4, 9 and 27 in Histone H3 of HeLa Cells.
Topics: DNA Methylation; Female; HeLa Cells; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methyltransferases; Uterine Cervical Neoplasms; Valproic Acid | 2023 |