valproic acid and lithium chloride

valproic acid has been researched along with lithium chloride in 87 studies

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (10.34)	18.2507
2000's	40 (45.98)	29.6817
2010's	36 (41.38)	24.3611
2020's	2 (2.30)	2.80

Authors

Authors	Studies
Brenstrum, T; Capretta, A; Kim, AJ; Ohnmacht, SA; Panna, E; Werstuck, GH	1
Wang, JF; Young, LT	1
George, B; Kulkarni, SK	1
Woods, CM; Young, LT	1
Lenox, RH; McNamara, RK; Watson, DG; Watterson, JM	1
Barros, HM; Tannhauser, M; Vargas, C	1
Lenox, RH; Watson, DG; Watterson, JM	1
Asghari, V; Reiach, JS; Wang, JF; Young, LT	1
Asghari, V; Rockel, C; Wang, JF; Young, LT	1
Chen, B; Hill, BC; Wang, JF; Young, LT	1
Joffe, RT; MacQueen, GM; Marriott, M; Patelis-Siotis, I; Robb, JC; Young, LT	1
Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E	1
Chang, KD; Ketter, TA	1
Ida, S; Nishimoto, A; Shibata, S; Sugawara, A; Takiguchi, Y; Yokota, M; Yoshioka, H	1
Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M	1
El-Mallahk, RS; Li, R	1
Bottlender, R; Möller, HJ; Rudolf, D; Strauss, A	1
Chen, G; Huang, LD; K Manji, H; Zeng, WZ	1
Bown, CD; Chen, B; Wang, JF; Young, LT	1
Conn, DK; Robillard, M	1
De Sarno, P; Jope, RS; Li, X	1
Kawano, K; Morinobu, S; Tanaka, K; Tsuji, S; Yamawaki, S	1
Asghar, SJ; Dunn, SM; Greenshaw, A; Jurasz, P; Radomski, M; Rotzinger, S; Silverstone, PH; Tanay, VA; Ulrich, ML	1
Chen, PS; Lo, YC; Wang, YT; Yang, YK; Yeh, TL	1
Davanzo, P; Koski, ME; Saldarini, CT; Yehya, N	1
Breier, A; Namjoshi, MA; Risser, R; Shi, L; Tohen, M	1
Altar, CA; Drabik, CE; Laeng, P; Lemire, AL; Mallon, BS; Pitts, RL; Tang, H; Thyagarajan, R; Weiner, A	1
Alevizos, B; Boufidou, F; Christodoulou, GN; Liappas, IA; Nikolaou, C	1
Friedman, E; Hahn, CG; Koneru, R; Levinson, DF; Wang, HY	1
Bazinet, RP; Ertley, RN; Lee, HJ; Rao, JS; Rapoport, SI	1
Kato, N; Kato, T; Kazuno, AA; Munakata, K	1
Amboni, G; Assis, LC; Corrêa, C; Kapczinski, F; Martins, MR; Quevedo, J; Streck, EL	1
Battastini, AM; Bernardi, A; Cimarosti, H; Frozza, RL; Marques, AL; Rocha, E; Salbego, C; Wilot, LC	1
Atbasoglu, EC; Bilgic, A; Goker, C; Olmez, S; Oncu, B; Senturk, V; Tugcu, H	1
Chuang, DM; Liang, MH; Marinova, Z; Yahyavi, A; Yasuda, S	1
Chen, G; Creson, TK; Engel, SR; Hao, Y; Landreth, GE; Maeng, S; Manji, HK; Nekrasova, T; Shen, Y	1
Kilts, JD; Madison, RD; Manji, HK; Marx, CE; Shampine, LJ; Yuan, P	1
Desrosiers, RR; Lamarre, M	1
Coleman, MD; Hill, EJ; Prince, M; Woehrling, EK	1
Chuang, DM; Feng, HL; Leng, Y; Ma, CH; Ren, M; Zhang, J	1
Andreazza, AC; Frey, BN; Giasson, K; Gonçalves, CA; Kapczinski, F; Kauer-Sant'Anna, M; Quevedo, J; Réus, GZ; Ribeiro, L; Salvador, M; Stertz, L; Valvassori, SS; Zanotto, C	1
Adler, JT; Chen, H; Hottinger, DG; Kunnimalaiyaan, M	2
Bain, EE; Cannon, DM; Drevets, WC; Erickson, K; Holmes, MK; Luckenbaugh, DA; Manji, HK; Sahakian, BJ; Snow, J; Zarate, CA	1
Anderson, E; Brown, R; Forster, S; Gibson, GG; Lyon, J; Plant, KE; Plant, N; Simecek, N; Spinks, J; Toms, N	1
Mavrikaki, M; Nomikos, GG; Panagis, G	1
Bundo, M; Iwamoto, K; Kakiuchi, C; Kato, T; Washizuka, S	1
Chan, MK; Di Daniel, E; Ellis, CL; Gallagher, KT; Glover, CP; Grot, E; Maycox, PR; Mudge, AW; Sanderson, TH; Thomas, J; Uney, J; White, JH	1
Kwan, M; Li, PP; Perova, T; Warsh, JJ	1
Choinski, M; Flood, DG; Gasior, M; Marino, MJ	1
Bialer, M; Boris, Y; Dalton, EC; Harwood, AJ; Shimshoni, JA; Watson, P	1
Arent, CO; Ferreira, CL; Fries, GR; Jornada, LK; Kapczinski, F; Moretti, M; Padilha, PT; Quevedo, J; Valvassori, SS	1
Dager, SR; Dunner, DL; Friedman, SD; Kim, JE; Lyoo, IK; Renshaw, PF; Yoon, SJ	1
Akiskal, HS; Berloffa, S; D'Amico, F; Gagliano, A; Masi, G; Millepiedi, S; Mucci, M; Pari, C; Perugi, G; Pfanner, C	1
Arent, CO; Dal-Pizzol, F; Ferreira, CL; Jornada, LK; Mina, F; Moretti, M; Quevedo, J; Steckert, AV; Valvassori, SS	1
Cepa, S; Machado, A; Mesquita, J; Silva, L	1
Baldessarini, RJ	1
Alda, M; O'Donovan, C	1
Dalgard, CL; Doughty, ML; Wynder, C; Zhou, Q	1
Calabrese, JR; Ice, KS; Karayal, ON; Kemp, DE; Pappadopulos, E; Sachs, GS; Siu, CO; Vieta, E	1
Kurita, M; Nakahata, N; Nishino, S; Numata, Y; Ohtomo, K; Sato, T	1
Izumi, T; Kumamoto, H; Minami, M; Ohmura, Y; Tsutsui-Kimura, I; Yamaguchi, T; Yoshida, T; Yoshioka, M	1
Akula, N; Chatterjee, N; Chen, DT; Cheng, A; Cichon, S; Cohen-Woods, S; Craig, I; Farmer, A; Hosang, G; Jamain, S; Jiang, X; Kassem, L; Kennedy, JL; Leboyer, M; Lewis, C; McGuffin, P; McMahon, FJ; Muglia, P; Nöthen, MM; Park, JH; Rietschel, M; Schulze, TG; Shugart, YY; Steele, CJ; Strauss, J; Vincent, JB; Wendland, JR	1
Chen, RF; Huang, TL; Hung, YY; Lee, CT	1
Jeanray, N; Martial, JA; Muller, M; Piot, A; Pruvot, B; Quiroz, Y; Voncken, A	1
Bellivier, F; Etain, B; Geoffroy, PA; Henry, C	1
Calabrese, JR; Chan, PK; Conroy, C; Fein, EB; Ganocy, SJ; Gao, K; Kemp, DE; Obral, S	1
Coleman, MD; Devitt, A; Hill, EJ; Nagel, DA; O'Neil, JD; Torr, E; Woehrling, EK	1
Gould, TD; Grahame, NJ; Halcomb, ME	1
Chiu, IM; Chung, YF; Hsu, YC; Kao, CY; Lee, DC; Liu, JW	1
D'Souza, UM; Farmer, AE; Haddley, K; Mcguffin, P; Powell, TR; Powell-Smith, G; Quinn, J; Schalkwyk, LC	1
Golebiowska, J; Holuj, M; Kregiel, J; Popik, P; Rygula, R	1
Sharma, S; Taliyan, R	1
Akay, A; Baykara, B; Cevher, N; Guleryuz, H; Inal-Emiroglu, FN; Karabay, N; Resmi, H	1
Hoffman, R; Iancu-Rubin, C	1
Dong, GT; Feng, HL; Jiang, HQ; Jiang, HZ; Qi, Y; Ren, M; Wang, J; Wang, SY; Wang, TH; Wang, XD; Yang, YQ; Yin, X	1
Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L	1
Babenko, VA; Gulyaev, MV; Pevzner, IB; Pirogov, YA; Plotnikov, EY; Savchenko, ES; Silachev, DN; Sukhikh, GT; Zorov, DB; Zorova, LD	1
Callaerts, P; Del-Favero, J; Forero, D; Hens, K; Herteleer, L; Zwarts, L	1
Chiu, CT; Chuang, DM; Leng, Y; Liao, HM; Linares, GR; Maric, D; Scheuing, L	1
Baldwin, R; Lumley, L; Niquet, J; Norman, K; Suchomelova, L; Wasterlain, CG	1
Chen, CC; Cheng, CY; Huang, MC; Lee, YL; Leu, SJ; Liu, HC; Liu, KJ; Shen, WW; Wu, YC; Yang, YY	1
Callari, A; Colom, F; Goikolea, JM; Gonzalez de la Presa, B; Murru, A; Pacchiarotti, I; Pérez-Sola, V; Romero, S; Torra, M; Varo, C; Vieta, E	1
Figueiredo, EG; Welling, LC; Welling, MS	1
Han, J; Hong, SG; Kang, D; Kim, EJ; Lee, DK	1
Harada, H; Jung, HS; Jung, YS; Kim, HY; Lee, DJ; Li, S; Muramatsu, T; Park, JH	1
Bocci, G; Calabrò, PF; Carli, M; Fini, E; Natale, G; Scarselli, M	1

Reviews

5 review(s) available for valproic acid and lithium chloride

Article	Year
Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability. The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:1 Topics: Animals; Antimanic Agents; Bipolar Disorder; Cell Survival; Enoyl-CoA Hydratase; Humans; Intracellular Signaling Peptides and Proteins; Lithium Chloride; Mood Disorders; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA-Binding Proteins; RNA, Messenger; Transcription Factor AP-1; Valproic Acid	2001
Identification of mood stabilizer-regulated genes by differential-display PCR. The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:1 Topics: Animals; Antimanic Agents; Bipolar Disorder; Carrier Proteins; Cerebral Cortex; Endoplasmic Reticulum Chaperone BiP; Gene Expression Profiling; Gene Expression Regulation; Heat-Shock Proteins; Humans; Lithium Chloride; Molecular Chaperones; Polymerase Chain Reaction; RNA, Messenger; Valproic Acid	2001
Combination therapy for manic phases: a critical review of a common practice. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:12 Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Drug Therapy, Combination; Humans; Lithium Chloride; Valproic Acid	2012
Role of epigenetic reprogramming in hematopoietic stem cell function. Current opinion in hematology, 2015, Volume: 22, Issue:4 Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Proliferation; Cellular Reprogramming; Chromatin; Cytokines; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Lithium Chloride; Valproic Acid	2015
Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors? Cancer letters, 2023, 04-28, Volume: 560 Topics: Antimanic Agents; Bipolar Disorder; Brain Neoplasms; Glioblastoma; Humans; Lithium; Lithium Carbonate; Lithium Chloride; Pharmaceutical Preparations; Valproic Acid	2023

Trials

7 trial(s) available for valproic acid and lithium chloride

Article	Year
Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression. The American journal of psychiatry, 2000, Volume: 157, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Lithium Chloride; Male; Paroxetine; Patient Dropouts; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid	2000
Quality of life assessment in patients with bipolar disorder treated with olanzapine added to lithium or valproic acid. Journal of affective disorders, 2004, Volume: 81, Issue:3 Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Lithium Chloride; Male; Olanzapine; Placebos; Quality of Life; Treatment Outcome; Valproic Acid	2004
Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients. Journal of psychiatric research, 2005, Volume: 39, Issue:4 Topics: Adult; Antimanic Agents; Bipolar Disorder; Blood Platelets; Enzyme Activation; Female; GTP-Binding Proteins; Humans; Lithium Chloride; Male; Protein Kinase C; Schizophrenia; Signal Transduction; Valproic Acid	2005
A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar disorders, 2008, Volume: 10, Issue:7 Topics: Adult; Affect; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Cognition; Female; Humans; Lithium Chloride; Male; Middle Aged; Neuropsychological Tests; Valproic Acid; Young Adult	2008
Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:8 Topics: Adult; Antimanic Agents; Bipolar Disorder; Brain; Brain Mapping; Female; Humans; Image Processing, Computer-Assisted; Lithium Chloride; Longitudinal Studies; Magnetic Resonance Imaging; Male; Time Factors; Valproic Acid; Young Adult	2010
Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:2 Topics: Adjuvants, Immunologic; Antipsychotic Agents; Bipolar Disorder; Body Weight; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lithium Chloride; Longitudinal Studies; Male; Metabolic Diseases; Metabolome; Piperazines; Psychiatric Status Rating Scales; Thiazoles; Valproic Acid	2012
Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorder. Bipolar disorders, 2012, Volume: 14, Issue:7 Topics: Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lamotrigine; Lithium Chloride; Male; Middle Aged; Psychiatric Status Rating Scales; Retrospective Studies; Triazines; Valproic Acid; Young Adult	2012

Other Studies

75 other study(ies) available for valproic acid and lithium chloride

Article	Year
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22 Topics: Anticonvulsants; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Molecular Structure; Valproic Acid	2004
Differential display PCR reveals increased expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase by lithium. FEBS letters, 1996, May-20, Volume: 386, Issue:2-3 Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Base Sequence; Carbamazepine; Gene Expression; Humans; Lithium Chloride; Molecular Sequence Data; Neuroglia; Oligodeoxyribonucleotides; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Sodium Chloride; Tumor Cells, Cultured; Valproic Acid	1996
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus. Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18, Issue:5 Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; gamma-Aminobutyric Acid; Lithium Chloride; Male; Neuroprotective Agents; Pentobarbital; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Valproic Acid	1996
Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells. European journal of pharmacology, 1996, Aug-08, Volume: 309, Issue:2 Topics: Adenosine Diphosphate Ribose; Animals; Carbamazepine; Glioma; Lithium Chloride; Rats; Tumor Cells, Cultured; Valproic Acid	1996
Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 13 Topics: Animals; Bipolar Disorder; Blotting, Western; Carbamazepine; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Gene Expression; Hippocampus; Humans; Inositol; Intracellular Signaling Peptides and Proteins; Lithium Chloride; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Protein Biosynthesis; Protein Kinase C; Proteins; Rabbits; Rats; Valproic Acid	1996
Dissimilar effects of lithium and valproic acid on GABA and glutamine concentrations in rat cerebrospinal fluid. General pharmacology, 1998, Volume: 30, Issue:4 Topics: Animals; Antimanic Agents; Female; gamma-Aminobutyric Acid; Glutamine; Hyponatremia; Lithium Chloride; Rats; Rats, Wistar; Valproic Acid	1998
Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1 Topics: Animals; Antimanic Agents; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cytidine Monophosphate; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Glycerophospholipids; Hippocampus; Intracellular Signaling Peptides and Proteins; Lithium Chloride; Membrane Proteins; Muscarinic Agonists; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidic Acids; Protein Kinase C; Proteins; Valproic Acid	1998
Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells. Brain research. Molecular brain research, 1998, Jul-15, Volume: 58, Issue:1-2 Topics: Antimanic Agents; Base Sequence; Binding Sites; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Lithium Chloride; Neuroblastoma; Nuclear Proteins; Oligodeoxyribonucleotides; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid	1998
Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells. Neuroscience, 1999, Volume: 91, Issue:2 Topics: Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Humans; Kinetics; Lithium Chloride; Neuroblastoma; Phosphorylation; Signal Transduction; Tumor Cells, Cultured; Valproic Acid	1999
Lithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-Fos. Brain research. Molecular brain research, 1999, Jun-18, Volume: 70, Issue:1 Topics: Animals; Antimanic Agents; Cyclic AMP Response Element-Binding Protein; Drug Administration Schedule; Gene Expression Regulation; Hippocampus; Lithium Chloride; Male; Nerve Tissue Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Valproic Acid	1999
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. Brain research, 2000, Feb-07, Volume: 855, Issue:1 Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Response Relationship, Drug; Humans; Inositol; Lithium Chloride; Signal Transduction; Tritium; Tumor Cells, Cultured; Valproic Acid	2000
Mood stabilizer augmentation with olanzapine in acutely manic children. Journal of child and adolescent psychopharmacology, 2000,Spring, Volume: 10, Issue:1 Topics: Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Bipolar Disorder; Child; Drug Therapy, Combination; Humans; Lithium Chloride; Male; Olanzapine; Pirenzepine; Sleep Stages; Valproic Acid; Weight Gain	2000
Effects of lithium on the pharmacokinetics of valproate in rats. The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:3 Topics: Animals; Antimanic Agents; Cytochrome P-450 Enzyme System; Glucuronates; Glucuronosyltransferase; Lithium Chloride; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Wistar; Time Factors; Valproic Acid	2000
Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain research, 2000, Oct-13, Volume: 880, Issue:1-2 Topics: Animals; Brain; Dextroamphetamine; Inositol; Inositol Phosphates; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Valproic Acid	2000
A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency. Neuroscience letters, 2000, Nov-24, Volume: 294, Issue:3 Topics: Antimanic Agents; Apoptosis; Caspase 3; Caspases; Humans; Ionophores; L-Lactate Dehydrogenase; Lithium Chloride; Neuroblastoma; Tumor Cells, Cultured; Valinomycin; Valproic Acid	2000
Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients. Journal of affective disorders, 2001, Volume: 63, Issue:1-3 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antimanic Agents; Bipolar Disorder; Carbamazepine; Depressive Disorder; Female; Humans; Lithium Chloride; Male; Middle Aged; Retrospective Studies; Risk Factors; Treatment Outcome; Valproic Acid	2001
Lamotrigine use in geriatric patients with bipolar depression. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2002, Volume: 47, Issue:8 Topics: Aged; Aged, 80 and over; Antimanic Agents; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lamotrigine; Lithium Chloride; Male; Triazines; Valproic Acid	2002
Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology, 2002, Volume: 43, Issue:7 Topics: Animals; Brain; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lithium Chloride; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Valproic Acid	2002
Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:4 Topics: Animals; Brain; Enzyme Activation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Lithium Chloride; Male; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Valproic Acid	2003
Effects of dextroamphetamine, lithium chloride, sodium valproate and carbamazepine on intraplatelet Ca2+ levels. Journal of psychiatry & neuroscience : JPN, 2003, Volume: 28, Issue:2 Topics: Adolescent; Adult; Antipsychotic Agents; Blood Platelets; Calcium Channels; Carbamazepine; Dextroamphetamine; Female; Humans; Lithium Chloride; Male; Middle Aged; Thrombin; Valproic Acid	2003
Nonketotic hyperosmolar syndrome from olanzapine, lithium, and valproic acid cotreatment. The Annals of pharmacotherapy, 2003, Volume: 37, Issue:6 Topics: Adult; Benzodiazepines; Drug Therapy, Combination; Humans; Hyperglycinemia, Nonketotic; Lithium Chloride; Male; Olanzapine; Pirenzepine; Valproic Acid	2003
Valproate-induced hyperammonemic encephalopathy. Journal of the American Academy of Child and Adolescent Psychiatry, 2004, Volume: 43, Issue:8 Topics: Aggression; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorders; Child; Diagnosis, Differential; Dibenzothiazepines; Disruptive, Impulse Control, and Conduct Disorders; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroencephalography; Humans; Hyperammonemia; Lithium Chloride; Liver Function Tests; Male; Neurotoxicity Syndromes; Quetiapine Fumarate; Valproic Acid	2004
The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. Journal of neurochemistry, 2004, Volume: 91, Issue:1 Topics: Animals; Astrocytes; bcl-Associated Death Protein; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Cell Count; Cell Differentiation; Cells, Cultured; Cyclin D2; Cyclins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lithium Chloride; Neurons; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Time Factors; Trans-Activators; Tretinoin; Tubulin; Valproic Acid	2004
Cytokine production in bipolar affective disorder patients under lithium treatment. Journal of affective disorders, 2004, Oct-15, Volume: 82, Issue:2 Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cytokines; Down-Regulation; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lithium Chloride; Long-Term Care; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Recurrence; Valproic Acid	2004
Chronic treatment with mood stabilizers increases membrane GRK3 in rat frontal cortex. Biological psychiatry, 2007, Jan-15, Volume: 61, Issue:2 Topics: Animals; Anticonvulsants; Antimanic Agents; beta-Adrenergic Receptor Kinases; Blotting, Western; Carbamazepine; Cytosol; Frontal Lobe; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Lithium Chloride; Male; Rats; Rats, Inbred F344; Synaptic Membranes; Valproic Acid	2007
Mitochondrial DNA-dependent effects of valproate on mitochondrial calcium levels in transmitochondrial cybrids. The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:1 Topics: Adult; Antimanic Agents; Calcium; Calcium Signaling; Cell Line; Cell Nucleus; DNA, Mitochondrial; Female; Histamine; Humans; Hybrid Cells; Lithium Chloride; Male; Mitochondria; Valproic Acid	2008
Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania. Progress in neuro-psychopharmacology & biological psychiatry, 2007, May-09, Volume: 31, Issue:4 Topics: Amphetamine; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Citrate (si)-Synthase; Disease Models, Animal; Drug Interactions; Hippocampus; Lithium Chloride; Male; Rats; Rats, Wistar; Valproic Acid	2007
Lithium and valproate protect hippocampal slices against ATP-induced cell death. Neurochemical research, 2007, Volume: 32, Issue:9 Topics: Adenosine Triphosphate; Animals; Cell Death; Hippocampus; Lithium Chloride; Male; Rats; Rats, Wistar; Valproic Acid	2007
Impaired verbal memory and otherwise spared cognition in remitted bipolar patients on monotherapy with lithium or valproate. Bipolar disorders, 2007, Volume: 9 Suppl 1 Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Cognition Disorders; Diagnostic and Statistical Manual of Mental Disorders; Evaluation Studies as Topic; Female; Humans; Intelligence Tests; Lithium Chloride; Male; Memory; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Problem Solving; Valproic Acid; Verbal Learning	2007
The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Molecular psychiatry, 2009, Volume: 14, Issue:1 Topics: Animals; Antimanic Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Lithium Chloride; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Chloride; Promoter Regions, Genetic; Rats; RNA, Messenger; RNA, Small Interfering; Time Factors; Transfection; Valproic Acid	2009
The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement. Molecular psychiatry, 2009, Volume: 14, Issue:4 Topics: Adjuvants, Immunologic; Administration, Oral; Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Central Nervous System Stimulants; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Lithium Chloride; Locomotion; Maze Learning; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3; Olanzapine; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Swimming; Valproic Acid	2009
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:4 Topics: Affect; Animals; Antimanic Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; DNA; Gas Chromatography-Mass Spectrometry; Genes, bcl-2; Lithium Chloride; Male; Mice; Mice, Knockout; Neuronal Plasticity; Prefrontal Cortex; Pregnanolone; Pregnenolone; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid	2008
Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization. Neuropharmacology, 2008, Volume: 55, Issue:5 Topics: Adjuvants, Immunologic; Astrocytoma; beta Catenin; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Lithium Chloride; Protein D-Aspartate-L-Isoaspartate Methyltransferase; RNA, Messenger; RNA, Small Interfering; Time Factors; Up-Regulation; Valproic Acid	2008
Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology, 2008, Jul-30, Volume: 249, Issue:2-3 Topics: Acrylamides; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Densitometry; Gene Expression; Humans; Hydroxyurea; Image Processing, Computer-Assisted; Immunohistochemistry; Lithium Chloride; Microscopy, Confocal; Models, Neurological; Nervous System Diseases; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Teratogens; Tretinoin; Valproic Acid	2008
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience, 2008, Aug-26, Volume: 155, Issue:3 Topics: Adjuvants, Immunologic; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Hindlimb Suspension; Humans; Lithium Chloride; Mice; Mice, Transgenic; Motor Activity; Muscle Strength; Mutation; Nervous System Diseases; Psychomotor Performance; Reflex; Rotarod Performance Test; Superoxide Dismutase; Survival Analysis; Valproic Acid	2008
Effects of mood stabilizers on DNA damage in an animal model of mania. Journal of psychiatry & neuroscience : JPN, 2008, Volume: 33, Issue:6 Topics: Amphetamine; Animals; Antimanic Agents; Antioxidants; Bipolar Disorder; Central Nervous System Stimulants; Comet Assay; DNA Damage; Hippocampus; Lipid Peroxidation; Lithium Chloride; Male; Micronucleus Tests; Motor Activity; Oxidative Stress; Rats; Rats, Wistar; Valproic Acid	2008
Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. Annals of surgical oncology, 2009, Volume: 16, Issue:2 Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoid Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromogranin A; Enzyme Inhibitors; Gastrointestinal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Lithium Chloride; Luciferases; Lung Neoplasms; Receptor, Notch1; Valproic Acid	2009
The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicology and applied pharmacology, 2009, Feb-15, Volume: 235, Issue:1 Topics: Antimanic Agents; Apoptosis; Cell Line, Tumor; Gene Expression Profiling; Gene Silencing; Homeodomain Proteins; Humans; Lithium Chloride; Neuroblastoma; Staurosporine; Up-Regulation; Valproic Acid	2009
Effects of mood stabilizers on brain reward processes in rats: studies using the intracranial self-stimulation paradigm. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:3 Topics: Analysis of Variance; Animals; Antimanic Agents; Behavior, Animal; Brain; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Combinations; Lithium Chloride; Male; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Valproic Acid	2009
Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. Neuroscience research, 2009, Volume: 63, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antimanic Agents; Bipolar Disorder; Cell Line, Transformed; Female; Gene Expression; Genotype; Humans; Lithium Chloride; Lymphocytes; Male; Middle Aged; NADH Dehydrogenase; RNA, Messenger; Schizophrenia; Statistics, Nonparametric; Up-Regulation; Valproic Acid	2009
Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Molecular and cellular neurosciences, 2009, Volume: 41, Issue:3 Topics: Animals; Antimanic Agents; Carbamazepine; Cell Culture Techniques; DNA, Complementary; GAP-43 Protein; Growth Cones; Humans; Indoles; Lamotrigine; Lithium Chloride; Mice; Mice, Knockout; Phosphatidylinositols; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Thiazolidines; Triazines; Valproic Acid	2009
Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. The Journal of surgical research, 2010, Volume: 159, Issue:2 Topics: Cell Division; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lithium Chloride; Receptor, Notch1; Thyroid Neoplasms; Tumor Cells, Cultured; Up-Regulation; Valproic Acid	2010
Differential modulation of intracellular Ca2+ responses in B lymphoblasts by mood stabilizers. The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:6 Topics: Adult; Antimanic Agents; B-Lymphocytes; Bipolar Disorder; Calcium; Cell Line, Transformed; Drug Interactions; Enzyme Inhibitors; Female; Humans; Intracellular Fluid; Lipopolysaccharides; Lithium Chloride; Male; Middle Aged; Thapsigargin; Valproic Acid	2010
Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice. Psychopharmacology, 2009, Volume: 205, Issue:3 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Antimanic Agents; Carbamazepine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Fructose; Injections, Intraperitoneal; Lamotrigine; Lithium Chloride; Male; Mice; Mice, Inbred DBA; Reflex, Startle; Topiramate; Triazines; Valproic Acid	2009
Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology. Neuropharmacology, 2009, Volume: 56, Issue:4 Topics: Actins; Animals; Animals, Newborn; Antimanic Agents; Carbamazepine; Cytoskeleton; Ganglia, Spinal; Gene Expression; Growth Cones; Immunohistochemistry; Lithium Chloride; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Stereoisomerism; T-Lymphocytes; Valproic Acid	2009
Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain. Journal of psychiatric research, 2010, Volume: 44, Issue:8 Topics: Amygdala; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Lithium Chloride; Male; Motor Activity; Ouabain; Rats; Rats, Wistar; Valproic Acid	2010
Pharmacological response in juvenile bipolar disorder subtypes: A naturalistic retrospective examination. Psychiatry research, 2010, May-15, Volume: 177, Issue:1-2 Topics: Adolescent; Age Factors; Antimanic Agents; Bipolar Disorder; Child; Drug Therapy, Combination; Female; Humans; Lithium Chloride; Male; Psychiatric Status Rating Scales; Retrospective Studies; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome; Valproic Acid	2010
Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania. Journal of psychiatric research, 2011, Volume: 45, Issue:2 Topics: Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Catalase; Disease Models, Animal; Drug Interactions; Gene Expression Regulation, Enzymologic; Injections, Intraventricular; Lithium Chloride; Male; Ouabain; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Valproic Acid	2011
Lithium neurotoxicity at normal serum levels. The Journal of neuropsychiatry and clinical neurosciences, 2010,Fall, Volume: 22, Issue:4 Topics: Antimanic Agents; Bipolar Disorder; Humans; Lithium Chloride; Male; Middle Aged; Neurotoxicity Syndromes; Psychomotor Performance; Valproic Acid	2010
Commentary: the Bipolar Affective Disorder: Lithium/Anticonvulsant Evaluation (BALANCE) study. Bipolar disorders, 2010, Volume: 12, Issue:7 Topics: Anticonvulsants; Bipolar Disorder; Humans; Lithium Chloride; Randomized Controlled Trials as Topic; Valproic Acid	2010
A much needed BALANCE. Bipolar disorders, 2010, Volume: 12, Issue:7 Topics: Anticonvulsants; Bipolar Disorder; Drug Therapy, Combination; Humans; Lithium Chloride; Valproic Acid	2010
Valproic acid inhibits neurosphere formation by adult subventricular cells by a lithium-sensitive mechanism. Neuroscience letters, 2011, Aug-18, Volume: 500, Issue:3 Topics: Adult Stem Cells; Animals; Anticonvulsants; Antimanic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Proliferation; Cells, Cultured; Cerebral Ventricles; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; DNA; Drug Antagonism; Early Growth Response Protein 1; Female; Histone Deacetylase Inhibitors; Lithium Chloride; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multipotent Stem Cells; Neurogenesis; Phosphorylation; Transcription, Genetic; Valproic Acid	2011
Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations. Progress in neuro-psychopharmacology & biological psychiatry, 2012, Oct-01, Volume: 39, Issue:1 Topics: Astrocytes; Brain-Derived Neurotrophic Factor; Cell Count; Cell Line, Tumor; Humans; Lithium Chloride; Valproic Acid	2012
Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats. Psychopharmacology, 2012, Volume: 219, Issue:2 Topics: Animals; Carbamazepine; Choice Behavior; Dose-Response Relationship, Drug; Eating; Impulsive Behavior; Lithium Chloride; Male; Rats; Rats, Wistar; Reaction Time; Serial Learning; Valproic Acid	2012
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Molecular psychiatry, 2013, Volume: 18, Issue:2 Topics: Ankyrins; Antidepressive Agents; Asian People; Bipolar Disorder; Cell Line, Transformed; Cytokines; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lectins; Lithium Chloride; Male; Membrane Transport Proteins; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Receptors, Prostaglandin; RNA, Messenger; Time Factors; Valproic Acid; White People	2013
Serum protein levels of brain-derived neurotrophic factor and tropomyosin-related kinase B in bipolar disorder: effects of mood stabilizers. Neuropsychobiology, 2012, Volume: 65, Issue:2 Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Female; Humans; Lithium Chloride; Male; Middle Aged; Protein Kinases; Retrospective Studies; Valproic Acid; Young Adult	2012
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos. Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:4 Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish	2012
Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PloS one, 2013, Volume: 8, Issue:3 Topics: Cell Culture Techniques; Cell Cycle; Cell Line; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation; Humans; Lithium Chloride; Molecular Sequence Annotation; Neurogenesis; Octamer Transcription Factor-3; Phenotype; Reproducibility of Results; Stage-Specific Embryonic Antigens; Valproic Acid	2013
Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:10 Topics: Animals; Antimanic Agents; Choice Behavior; Conditioning, Operant; Female; Impulsive Behavior; Lithium Chloride; Male; Mice; Mice, Inbred Strains; Valproic Acid	2013
The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. Journal of neurochemistry, 2013, Volume: 126, Issue:1 Topics: Animals; Antimanic Agents; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Embryonic Stem Cells; Fibroblast Growth Factor 1; Flow Cytometry; Glycogen Synthase Kinase 3; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Immunohistochemistry; Lithium Chloride; Mice; Neural Stem Cells; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Small Interfering; Transcriptional Activation; Valproic Acid	2013
Mood-stabilizers differentially affect housekeeping gene expression in human cells. International journal of methods in psychiatric research, 2014, Volume: 23, Issue:2 Topics: Aged; Antimanic Agents; Cell Line, Transformed; Depression; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Genes, Essential; Humans; Lithium Chloride; Lymphocytes; Male; Middle Aged; RNA, Messenger; Time Factors; Valproic Acid	2014
Acute administration of lithium, but not valproate, modulates cognitive judgment bias in rats. Psychopharmacology, 2015, Volume: 232, Issue:12 Topics: Animals; Antimanic Agents; Cognition; Cues; Electroshock; Judgment; Lithium Chloride; Male; Rats; Rats, Sprague-Dawley; Valproic Acid	2015
Synergistic effects of GSK-3β and HDAC inhibitors in intracerebroventricular streptozotocin-induced cognitive deficits in rats. Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:3 Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Brain-Derived Neurotrophic Factor; Cognition Disorders; Drug Synergism; Drug Therapy, Combination; Glutathione; Glycogen Synthase Kinase 3; Histone Deacetylase Inhibitors; Insulin; Lithium Chloride; Malondialdehyde; Memory; Memory Disorders; Neuroprotective Agents; Nitrates; Nitrites; Rats, Wistar; Spatial Learning; Streptozocin; Valproic Acid	2015
Decreased right hippocampal volumes and neuroprogression markers in adolescents with bipolar disorder. Neuropsychobiology, 2015, Volume: 71, Issue:3 Topics: Adolescent; Antidepressive Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Disease Progression; Female; Functional Laterality; Hippocampus; Humans; Lithium Chloride; Magnetic Resonance Imaging; Male; Nerve Growth Factor; Statistics as Topic; Valproic Acid; Young Adult	2015
Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Neuroscience, 2015, Aug-20, Volume: 301 Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation; Humans; Lithium Chloride; Mice; Mice, Transgenic; Motor Neurons; Neuroprotective Agents; Receptors, Notch; RNA, Small Interfering; Signal Transduction; Spinal Cord; Superoxide Dismutase; Transfection; Valproic Acid	2015
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. Progress in neuro-psychopharmacology & biological psychiatry, 2015, Dec-03, Volume: 63 Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; Depression; Dextroamphetamine; Disease Models, Animal; Exploratory Behavior; Female; Food Preferences; Hyperkinesis; Lithium Chloride; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Ceroid-Lipofuscinoses; Sleep Wake Disorders; Swimming; Valproic Acid	2015
Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia. Bulletin of experimental biology and medicine, 2016, Volume: 160, Issue:3 Topics: Animals; Animals, Newborn; Brain Injuries; Hypoxia; Hypoxia-Ischemia, Brain; Lithium Chloride; Rats; Valproic Acid	2016
Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila. Psychopharmacology, 2016, Volume: 233, Issue:9 Topics: Animals; Antimanic Agents; Cell Line; Drosophila; Head; Immune System; Lithium Chloride; Metabolic Networks and Pathways; Microarray Analysis; Neurons; Transcription, Genetic; Valproic Acid	2016
Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease. Experimental neurology, 2016, Volume: 281 Topics: Animals; Antimanic Agents; Cytokines; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Administration Schedule; Female; Gene Expression; Huntingtin Protein; Huntington Disease; Lithium Chloride; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-kit; Receptors, Cytokine; Up-Regulation; Valproic Acid	2016
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits. Epilepsia, 2016, Volume: 57, Issue:9 Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ketamine; Learning Disabilities; Lithium Chloride; Male; Maze Learning; Midazolam; N-Methylscopolamine; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid	2016
Valproic Acid and Lithium Meditate Anti-Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function. Journal of cellular physiology, 2017, Volume: 232, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Arthritis, Experimental; Cattle; Cell Differentiation; Cell Polarity; Cytokines; Dendritic Cells; Inflammation; Interleukin-10; Interleukin-6; Interleukin-8; Lipid Metabolism; Lipopolysaccharides; Lithium Chloride; Mice; Monocytes; Th17 Cells; Toll-Like Receptors; Tumor Necrosis Factor-alpha; Valproic Acid	2017
A study on the bioequivalence of lithium and valproate salivary and blood levels in the treatment of bipolar disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017, Volume: 27, Issue:8 Topics: Adult; Antidepressive Agents; Bipolar Disorder; Female; Humans; Lithium Chloride; Male; Middle Aged; Psychiatric Status Rating Scales; Saliva; Therapeutic Equivalency; Valproic Acid	2017
Traumatic Brain Injury and Mood Stabilizers: Recent Cumulative Evidence. World neurosurgery, 2017, Volume: 105 Topics: Antimanic Agents; Brain Injuries, Traumatic; Humans; Lithium Chloride; Valproic Acid	2017
Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers. International journal of molecular sciences, 2017, Nov-19, Volume: 18, Issue:11 Topics: Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; HEK293 Cells; Hippocampus; Humans; Ion Channel Gating; Lithium Chloride; Neurons; Potassium Channels, Tandem Pore Domain; Valproic Acid	2017
Activation of Wnt signalling reduces the population of cancer stem cells in ameloblastoma. Cell proliferation, 2021, Volume: 54, Issue:7 Topics: Ameloblastoma; Animals; beta Catenin; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Size; Down-Regulation; Humans; Lithium Chloride; Mice; Mice, Nude; Neoplastic Stem Cells; SOXB1 Transcription Factors; Valproic Acid; Wnt Signaling Pathway	2021