valproic acid and isoniazid

valproic acid has been researched along with isoniazid in 44 studies

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (36.36)	18.7374
1990's	6 (13.64)	18.2507
2000's	8 (18.18)	29.6817
2010's	13 (29.55)	24.3611
2020's	1 (2.27)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Dansette, PM; Fontana, E; Poli, SM	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Perry, TL	1
Hansen, S; Perry, TL	1
Feussner, GK; Lust, WD; McCandless, DW; Passonneau, JV	1
Frey, HH; Löscher, W	1
Butler, IJ; Enna, SJ; Ferkany, JW	1
Biggio, G; Concas, A; Mascia, MP; Pepitoni, S; Sanna, E; Serra, M	1
Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, V; Serra, M	1
Dawson, DA; Wilke, TS	1
Autret, E; Barbier, P; Billard, C; Breteau, M; Gauchez, AS; Jonville, AP; Nsabiyumva, F	1
Støttum, A; Wiger, R	1
Dockweiler, U	1
Baciewicz, AM	1
Brunborg, G; Støttum, A; Wiger, R	1
Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M	1
Lauterburg, BH	1
Alterthum, K; Bauer, P; Stünkel, S; Windorfer, A	1
Geddes, JW; Wood, JD	1
Marsden, CD; Sheehy, MP	1
Perucca, E	1
Abel, MS; McCandless, DW; Schwartzenburg, FC	1
Biggs, CS; Fowler, LJ; Pearce, BR; Whitton, PS	1
Cao, BJ; Peng, NA	1
Fontana, RJ; Jinjuvadia, K; Kwan, W	1
Mattox, KM; Nesmith, MW; Stewart, JT	1
Ambroso, JI; Brown, HR; Falls, JG; Hunt, CM; Ilic, K; Miller, RT; Reese, MJ; Suzuki, A; Yuen, NA	1
Maeurer, M; Rao, M; Valentini, D; Zumla, A	1
Fasbender, F; Hengstler, JG; Metzler, S; Obholzer, M; Stöber, R; Watzl, C	1

Reviews

4 review(s) available for valproic acid and isoniazid

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics]. Schweizerische medizinische Wochenschrift, 1985, Sep-21, Volume: 115, Issue:38 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Glutathione; Halothane; Humans; Isoniazid; Liver; Perhexiline; Valproic Acid	1985

Trials

1 trial(s) available for valproic acid and isoniazid

Article	Year
GABA and movement disorders. Advances in biochemical psychopharmacology, 1981, Volume: 30 Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Movement Disorders; Muscimol; Parkinson Disease; Valproic Acid	1981

Other Studies

39 other study(ies) available for valproic acid and isoniazid

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Isoniazid and Huntington's chorea. The New England journal of medicine, 1978, May-11, Volume: 298, Issue:19 Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Rats; Valproic Acid	1978
Biochemical effects in man and rat of three drugs which can increase brain GABA content. Journal of neurochemistry, 1978, Volume: 30, Issue:4 Topics: Acetates; Adult; Amino Acids; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Rats; Valerates; Valproic Acid	1978
Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers. Journal of neurochemistry, 1979, Volume: 32, Issue:3 Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucose; Isoniazid; Lactates; Male; Mice; Seizures; Valproic Acid	1979
[On the mechanism of action of valproid acid]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:5 Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain Chemistry; Enzyme Activation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Mice; Valerates; Valproic Acid	1977
Effect of drugs on rat brain, cerebrospinal fluid and blood GABA content. Journal of neurochemistry, 1979, Volume: 33, Issue:1 Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Male; Organ Specificity; Rats; Valproic Acid	1979
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs. Epilepsy research. Supplement, 1992, Volume: 8 Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Culture Techniques; Epilepsy; gamma-Aminobutyric Acid; Isoniazid; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Synaptic Transmission; Valproic Acid	1992
"Ex vivo" binding of 35S-TBPS as a tool to study the pharmacology of GABAA receptors. Advances in biochemical psychopharmacology, 1990, Volume: 46 Topics: Alprazolam; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Diazepam; Drug Synergism; Ethanol; In Vitro Techniques; Isoniazid; Male; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Sulfur Radioisotopes; Valproic Acid	1990
Initial evaluation of developmental malformation as an end point in mixture toxicity hazard assessment for aquatic vertebrates. Ecotoxicology and environmental safety, 1991, Volume: 21, Issue:2 Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Butyrates; Embryo, Nonmammalian; Isoniazid; Teratogens; Valproic Acid; Vertebrates; Water Pollutants, Chemical; Xenopus	1991
Interaction between isoniazid and valproate: a case of valproate overdosage. European journal of clinical pharmacology, 1991, Volume: 40, Issue:2 Topics: Child, Preschool; Drug Interactions; Drug Overdose; Female; Humans; Isoniazid; Valproic Acid	1991
In vitro testing for developmental toxicity using the Hydra attenuata assay. NIPH annals, 1985, Volume: 8, Issue:2 Topics: Acetaminophen; Animals; Dimethyl Sulfoxide; Ethanol; Hexachlorocyclohexane; Hydra; Isoniazid; Regeneration; Teratogens; Toxicology; Valproic Acid	1985
Isoniazid-induced valproic-acid toxicity, or vice versa. Lancet (London, England), 1987, Jul-18, Volume: 2, Issue:8551 Topics: Adolescent; Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Tuberculosis; Valproic Acid	1987
Estimating chemical developmental hazard in a chicken embryo limb bud micromass system. Pharmacology & toxicology, 1988, Volume: 62, Issue:1 Topics: Animals; Cartilage; Cells, Cultured; Chick Embryo; Isoniazid; Proteoglycans; Salicylates; Teratogens; Time Factors; Tretinoin; Valproic Acid	1988
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. Journal of neural transmission, 1985, Volume: 63, Issue:2 Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Seizures; Time Factors; Valproic Acid	1985
[Effects of drug interaction in infancy (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1980, Volume: 128, Issue:10 Topics: Carbamazepine; Child; Chloramphenicol; Clonazepam; Dexamethasone; Drug Interactions; Humans; Isoniazid; Metronidazole; Phenobarbital; Phenytoin; Sulfonamides; Valproic Acid	1980
Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid. Journal of neurochemistry, 1984, Volume: 42, Issue:1 Topics: Amino Acids; Aminooxyacetic Acid; Animals; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrazines; Isoniazid; Male; Mice; Pyridoxal Phosphate; Pyridoxine; Synaptosomes; Valproic Acid	1984
Drug interactions in epilepsy. Arquivos de neuro-psiquiatria, 1980, Volume: 38, Issue:4 Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Humans; Isoniazid; Phenytoin; Valproic Acid	1980
Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. Journal of neuroscience research, 1982, Volume: 7, Issue:4 Topics: Adenosine Triphosphate; Animals; Cerebellar Cortex; Cerebral Cortex; Clonazepam; Energy Metabolism; Female; Glucose; Glycogen; Isoniazid; Mice; Phosphocreatine; Seizures; Valproic Acid	1982
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate. Journal of neurochemistry, 1994, Volume: 63, Issue:6 Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid	1994
Magnesium valproate attenuates hyperactivity induced by dexamphetamine-chlordiazepoxide mixture in rodents. European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Bicuculline; Chlordiazepoxide; Dextroamphetamine; Drug Interactions; Female; GABA-A Receptor Antagonists; Isoniazid; Mice; Motor Activity; Picrotoxin; Rats; Rats, Sprague-Dawley; Valproic Acid	1993
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury. The American journal of gastroenterology, 2007, Volume: 102, Issue:11 Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; International Classification of Diseases; Isoniazid; Liver Diseases; Male; Medical Records Systems, Computerized; Michigan; Middle Aged; Phenytoin; Population Surveillance; Sensitivity and Specificity; United States; Valproic Acid	2007
A case of valproate toxicity related to isoniazid. Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:6 Topics: Aged, 80 and over; Drug Interactions; Humans; Isoniazid; Lethargy; Male; Valproic Acid	2012
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. Regulatory toxicology and pharmacology : RTP, 2015, Volume: 72, Issue:3 Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Liver Injury; Data Mining; Databases, Factual; Drug Interactions; Isoniazid; Valproic Acid; World Health Organization	2015
Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018, Volume: 69 Topics: Antitubercular Agents; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoniazid; Macrophages; Mycobacterium tuberculosis; Rifampin; THP-1 Cells; Tuberculosis; Valproic Acid; Vorinostat	2018
Enhanced activation of human NK cells by drug-exposed hepatocytes. Archives of toxicology, 2020, Volume: 94, Issue:2 Topics: Antibodies, Neutralizing; Aspirin; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cytotoxicity Tests, Immunologic; Gene Expression Regulation; Hepatocytes; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoniazid; Ketoconazole; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3; NK Cell Lectin-Like Receptor Subfamily K; Valproic Acid	2020