valproic acid and inositol

valproic acid has been researched along with inositol in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (3.45)	18.2507
2000's	41 (70.69)	29.6817
2010's	11 (18.97)	24.3611
2020's	4 (6.90)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Lenox, RH; McNamara, RK; Watson, DG; Watterson, JM	1
Lubrich, B; van Calker, D	1
Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E	1
Bodor, N; Bruno-Blanch, L; Moon, SC	1
Greenberg, ML; Murray, M	1
Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M	2
Babb, SM; Breeze, JL; Cohen, BM; Frederick, BB; Gruber, SA; Hennen, J; Moore, CM; Renshaw, PF; Stoll, AL; Villafuerte, RA; Yurgelun-Todd, DA	1
Belmaker, RH; van Calker, D	1
Buttenfield, J; Chengappa, KN; Gershon, S; Hardan, A; Kupfer, DJ; Levine, J; Luther, J; Mallinger, AG; Pollock, B; Vagnucci, A; Verfaille, S	1
Ding, D; Greenberg, ML; Peterson, B; Vaden, DL	1
Belmaker, RH; Ding, D; Greenberg, ML; Ju, S; Shaldubina, A; Vaden, DL	1
Klisch, J; Schumacher, M; Spreer, J; Thiel, T; Ziyeh, S	1
Asghar, SJ; Hanstock, CC; O'Donnell, T; Silverstone, PH; Ulrich, M; Wu, RH	2
Agam, G; Greenberg, ML; Shaltiel, G; Shamir, A	1
Greenberg, ML; Zhong, Q	1
Agam, G; Harwood, AJ	1
Koyama, T; Nakagawa, S	1
Greenberg, ML; Ju, S	1
Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ	2
Agam, G; Greenberg, ML; Ju, S; Shaltiel, G; Shamir, A	1
Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M	1
Harwood, AJ	1
Agam, G; Belmaker, RH; Bialer, M; Dalton, E; Ding, D; Greenberg, ML; Harwood, AJ; Shaltiel, G; Shamir, A; Shapiro, J	1
Kim, H; McGrath, BM; Silverstone, PH	1
Ding, D; Geiger, JH; Greenberg, ML; Ju, S; Shi, Y; Vaden, DL	1
Finnell, RH; Giavini, E; Massa, V; Wlodarczyk, B	1
Culhane, M; Demopulos, C; Eden Evins, A; Grandin, LD; Nierenberg, AA; Ogutha, J; Sachs, GS; Yovel, I	1
Agam, G; Belmaker, RH; Dalton, EC; Harwood, AJ; Shaltiel, G	1
Bruno-Blanch, LE; Echeverría, GA; Ellena, J; Moon, SC; Punte, G	1
Greenshaw, AJ; McGrath, BM; McKay, R; Silverstone, PH; Slupsky, CM	1
Nurrish, SJ; Saiardi, A; Tokuoka, SM	1
Agam, G; Azab, AN; Campbell, A; Ding, D; Greenberg, ML; Mehta, DV; Pullumbi, E; Shaltiel, G; Shi, Y	1
Azab, AN; Chesebro, JE; Greenberg, ML; Mehta, DV	1
Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S	1
Moses, A; Potter, M; Wozniak, J	1
Dalton, E; Harwood, AJ; King, J; Ryves, J; Teo, R; Williams, RS	1
Terbach, N; Williams, RS	1
Di Daniel, E; Kew, JN; Maycox, PR	1
McGrath, BM; Silverstone, PH	1
Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B	1
Chaieb, L; Eikel, D; Elphick, LM; Guschina, IA; Harwood, JL; Nau, H; Pawolleck, N; Plant, NJ; Williams, RS	1
Caruso, JA; Deranieh, RM; Greenberg, ML; He, Q	1
Bellivier, F; Etain, B; Geoffroy, PA; Leboyer, M	1
Greenberg, ML; Ye, C	1
Chen, Y; Deranieh, RM; Greenberg, ML; Kane, PM; McCaffery, JM; Shi, Y; Tarsio, M	1
Cowart, LA; Greenberg, ML; Jadhav, S; Russo, S	1
Daniel, J; Greenberg, ML; Maddipati, KR; Mehta, D; Yu, W	1
Jagadeesan, R; Kothandan, G; Kumar, D; Kumar, N; Saha, S; Sinha, M	1
D'Ambrosio, F; Di Lorenzo, C; Janiri, L	1
Greenberg, ML; Lazcano, P; Onu, CJ; Schmidtke, MW	1
Cantelmi, T; Lepore, E; Unfer, V; Unfer, VR	1

Reviews

12 review(s) available for valproic acid and inositol

Article	Year
The high affinity inositol transport system--implications for the pathophysiology and treatment of bipolar disorder. Bipolar disorders, 2000, Volume: 2, Issue:2 Topics: Antimanic Agents; Biological Transport, Active; Bipolar Disorder; Carbamazepine; Carrier Proteins; Down-Regulation; Heat-Shock Proteins; Humans; Inositol; Lithium Compounds; Membrane Proteins; Symporters; Valproic Acid	2000
Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs. Bipolar disorders, 2002, Volume: 4 Suppl 1 Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Blood Cells; Enzyme Inhibitors; Eukaryotic Cells; Humans; Inositol; Lithium; Models, Biological; Phosphoric Monoester Hydrolases; Prefrontal Cortex; Saccharomyces cerevisiae; Valproic Acid	2002
Search for a common mechanism of mood stabilizers. Biochemical pharmacology, 2003, Jul-15, Volume: 66, Issue:2 Topics: Affect; Animals; Anticonvulsants; Antimanic Agents; Carbamazepine; Glycogen Synthase Kinase 3; Humans; Inositol; Lithium; Mood Disorders; Signal Transduction; Valproic Acid	2003
[Mechanism and clinical effects of drugs for mood disorder]. Ryoikibetsu shokogun shirizu, 2003, Issue:38 Topics: Antidepressive Agents; Antimanic Agents; Biogenic Monoamines; Humans; Inositol; Lithium; Meta-Analysis as Topic; Mood Disorders; Secondary Prevention; Synapses; Treatment Outcome; Valproic Acid	2003
Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. Molecular psychiatry, 2005, Volume: 10, Issue:1 Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Humans; Inositol; Lithium Compounds; Signal Transduction; Valproic Acid	2005
Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar disorders, 2005, Volume: 7, Issue:1 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Basal Ganglia; Bipolar Disorder; Frontal Lobe; Gyrus Cinguli; Humans; Inositol; Lithium Carbonate; Magnetic Resonance Spectroscopy; Temporal Lobe; Valproic Acid	2005
Alternative treatments in pediatric bipolar disorder. Child and adolescent psychiatric clinics of North America, 2009, Volume: 18, Issue:2 Topics: Acupuncture; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Child; Humans; Hypericum; Inositol; Lecithins; Lithium Carbonate; Melatonin; S-Adenosylmethionine; Valproic Acid	2009
Structure-function studies for the panacea, valproic acid. Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 5 Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kinase 3; HIV Infections; Humans; Inositol; Ion Channels; Migraine Disorders; Mitogen-Activated Protein Kinases; Molecular Structure; Phospholipases A2; Phospholipids; Signal Transduction; Structure-Activity Relationship; Teratogens; Valproic Acid; Virus Latency	2009
Investigation of the H(+)-myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling. Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 5 Topics: Animals; Antimanic Agents; Brain; Carbamazepine; Glucose Transport Proteins, Facilitative; Humans; Inositol; Lithium Compounds; Membrane Transport Proteins; Neurons; Phosphatidylinositols; Signal Transduction; Valproic Acid	2009
Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients. International review of psychiatry (Abingdon, England), 2009, Volume: 21, Issue:4 Topics: Affect; Animals; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brain; Humans; Inositol; Lithium Carbonate; Magnetic Resonance Spectroscopy; Reference Values; Second Messenger Systems; Treatment Outcome; Ubiquitin-Protein Ligases; Valproic Acid	2009
Can the response to mood stabilizers be predicted in bipolar disorder? Frontiers in bioscience (Elite edition), 2014, 01-01, Volume: 6, Issue:1 Topics: Antimanic Agents; Bipolar Disorder; Circadian Rhythm Signaling Peptides and Proteins; Genetic Association Studies; Genome-Wide Association Study; Humans; Inositol; Lithium; Neurotransmitter Agents; Pharmacogenetics; Phenotype; Valproic Acid	2014
Combined treatment of myo-inositol and d-chiro-inositol (80:1) as a therapeutic approach to restore inositol eumetabolism in patients with bipolar disorder taking lithium and valproic acid. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:17 Topics: Antimanic Agents; Bipolar Disorder; Dietary Supplements; Humans; Inositol; Lithium Compounds; Medication Adherence; Quality of Life; Valproic Acid	2021

Trials

5 trial(s) available for valproic acid and inositol

Article	Year
Inositol as an add-on treatment for bipolar depression. Bipolar disorders, 2000, Volume: 2, Issue:1 Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Blood-Brain Barrier; Carbamazepine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Inositol; Lithium; Male; Middle Aged; Pilot Projects; Treatment Outcome; Valproic Acid	2000
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. Human psychopharmacology, 2002, Volume: 17, Issue:7 Topics: Adult; Algorithms; Antimanic Agents; Bipolar Disorder; Brain Chemistry; Female; Frontal Lobe; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphatidylinositols; Psychiatric Status Rating Scales; Temporal Lobe; Valproic Acid	2002
Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients. International clinical psychopharmacology, 2003, Volume: 18, Issue:2 Topics: Adult; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Choline; Creatine; Drug Administration Schedule; Female; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Valproic Acid	2003
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy. Neurology, 2003, Oct-14, Volume: 61, Issue:7 Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid	2003
Inositol augmentation of lithium or valproate for bipolar depression. Bipolar disorders, 2006, Volume: 8, Issue:2 Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Female; Humans; Inositol; Lithium Carbonate; Male; Middle Aged; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires; Valproic Acid	2006

Other Studies

41 other study(ies) available for valproic acid and inositol

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 13 Topics: Animals; Bipolar Disorder; Blotting, Western; Carbamazepine; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Gene Expression; Hippocampus; Humans; Inositol; Intracellular Signaling Peptides and Proteins; Lithium Chloride; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Protein Biosynthesis; Protein Kinase C; Proteins; Rabbits; Rats; Valproic Acid	1996
Inhibition of the high affinity myo-inositol transport system: a common mechanism of action of antibipolar drugs? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:4 Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antimanic Agents; Astrocytes; Biological Transport; Brain; Carbamazepine; Carrier Proteins; Heat-Shock Proteins; Humans; Inositol; Lithium; Membrane Proteins; Rats; Rats, Wistar; RNA, Messenger; Symporters; Time Factors; Tumor Cells, Cultured; Valproic Acid	1999
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. Brain research, 2000, Feb-07, Volume: 855, Issue:1 Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Response Relationship, Drug; Humans; Inositol; Lithium Chloride; Signal Transduction; Tritium; Tumor Cells, Cultured; Valproic Acid	2000
Synthesis and pharmacological evaluation of prodrugs of valproic acid. Die Pharmazie, 2000, Volume: 55, Issue:3 Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Electroshock; Inositol; Magnetic Resonance Spectroscopy; Mice; Postural Balance; Prodrugs; Valproic Acid	2000
Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Molecular microbiology, 2000, Volume: 36, Issue:3 Topics: Amino Acid Sequence; Animals; Carbon; Cattle; Escherichia coli; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Genotype; Humans; Inositol; Lithium; Molecular Sequence Data; Open Reading Frames; Phosphoric Monoester Hydrolases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Valproic Acid; Xenopus laevis	2000
Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain research, 2000, Oct-13, Volume: 880, Issue:1-2 Topics: Animals; Brain; Dextroamphetamine; Inositol; Inositol Phosphates; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Valproic Acid	2000
Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar disorders, 2000, Volume: 2, Issue:3 Pt 2 Topics: Adult; Affect; Bipolar Disorder; Brain Mapping; Choline; Dominance, Cerebral; Female; Gyrus Cinguli; Humans; Inositol; Lithium Carbonate; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Psychiatric Status Rating Scales; Valproic Acid	2000
Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis. The Journal of biological chemistry, 2001, May-04, Volume: 276, Issue:18 Topics: Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Inositol; Lithium; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Valproic Acid	2001
Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase. Molecular psychiatry, 2002, Volume: 7, Issue:2 Topics: Anticonvulsants; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Inositol; Isomerism; Lithium; Myo-Inositol-1-Phosphate Synthase; Saccharomyces cerevisiae; Valproic Acid	2002
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy. Epilepsia, 2002, Volume: 43, Issue:9 Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid	2002
Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3 Topics: Animals; Anticonvulsants; Brain Chemistry; Central Nervous System Stimulants; Creatine; Dextroamphetamine; Glucose-6-Phosphate; Glycine; Inositol; Inositol Phosphates; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Valproic Acid	2003
Regulation of phosphatidylglycerophosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance. The Journal of biological chemistry, 2003, Sep-05, Volume: 278, Issue:36 Topics: Blotting, Northern; Carbon; CDPdiacylglycerol-Serine O-Phosphatidyltransferase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gene Expression Regulation; Gene Expression Regulation, Fungal; Genotype; Glucose; Glycerol; Inositol; Mitochondria; Mutation; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription, Genetic; Valproic Acid	2003
Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis. Molecular microbiology, 2003, Volume: 49, Issue:6 Topics: 5' Untranslated Regions; Basic Helix-Loop-Helix Transcription Factors; Blotting, Northern; CDPdiacylglycerol-Serine O-Phosphatidyltransferase; Cell Division; Electrophoresis, Agar Gel; Gene Expression Regulation, Fungal; Inositol; Myo-Inositol-1-Phosphate Synthase; Nucleic Acid Hybridization; Phospholipids; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Valproic Acid	2003
Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. The Journal of biological chemistry, 2004, May-21, Volume: 279, Issue:21 Topics: Amino Acid Sequence; Blotting, Western; Cations; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen-Ion Concentration; Inositol; Intramolecular Lyases; Kinetics; Molecular Sequence Data; Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Temperature; Time Factors; Valproic Acid	2004
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells. European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3 Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid	2004
Valproate decreases inositol biosynthesis. Biological psychiatry, 2004, Dec-01, Volume: 56, Issue:11 Topics: Amides; Animals; Animals, Newborn; Anticonvulsants; Blotting, Northern; Brain Chemistry; Cells, Cultured; Chromatography, Gas; Cyclopropanes; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression; Humans; In Vitro Techniques; Inositol; Male; Mice; Mice, Inbred ICR; Myo-Inositol-1-Phosphate Synthase; Neurons; Postmortem Changes; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Valproic Acid	2004
Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis. The Journal of biological chemistry, 2005, Dec-23, Volume: 280, Issue:51 Topics: Amino Acid Sequence; Base Sequence; DNA Primers; Glycolysis; Inositol; Lithium; Molecular Sequence Data; Mutation; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Triose-Phosphate Isomerase; Valproic Acid	2005
Myo-inositol enhances teratogenicity of valproic acid in the mouse. Birth defects research. Part A, Clinical and molecular teratology, 2006, Volume: 76, Issue:3 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Drug Synergism; Embryo Loss; Female; Fetal Weight; Injections, Intraperitoneal; Inositol; Mice; Mice, Inbred Strains; Neural Tube Defects; Pregnancy; Species Specificity; Teratogens; Valproic Acid	2006
Specificity of mood stabilizer action on neuronal growth cones. Bipolar disorders, 2007, Volume: 9, Issue:3 Topics: Animals; Animals, Newborn; Ganglia, Spinal; Inositol; Lithium Compounds; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spinal Cord; Valproic Acid	2007
The effect of sodium valproate on proton MRS visible neurochemical concentrations. Epilepsy research, 2007, Volume: 74, Issue:2-3 Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Valproic Acid	2007
Crystal structure and anticonvulsant activity of (+/-)-1,2:4,5-di-O-isopropylidene-3,6-di-O-(2-propylpentanoyl)-myo-inositol. Carbohydrate research, 2007, Aug-13, Volume: 342, Issue:11 Topics: Animals; Anticonvulsants; Carbohydrate Conformation; Crystallography, X-Ray; Electroshock; Inositol; Mice; Pentylenetetrazole; Valproic Acid	2007
Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol. Neuroreport, 2007, Oct-08, Volume: 18, Issue:15 Topics: Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Brain Chemistry; Carbamazepine; Cerebral Cortex; Hippocampus; Inositol; Lamotrigine; Lithium Carbonate; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Triazines; Valproic Acid	2007
The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans. Molecular biology of the cell, 2008, Volume: 19, Issue:5 Topics: Acetylcholine; Animals; Antimanic Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Defecation; Diglycerides; Inositol; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Muscle Contraction; Mutation; Ovulation; Phosphatidylinositol 4,5-Diphosphate; Signal Transduction; Valproic Acid	2008
Yeast bioassay for identification of inositol depleting compounds. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 3 Topics: Anticonvulsants; Antimanic Agents; Biological Assay; Bipolar Disorder; Brain; Carboxylic Acids; Cell Proliferation; Chronic Disease; Humans; Inositol; Intracellular Space; Lithium Carbonate; Myo-Inositol-1-Phosphate Synthase; Saccharomyces cerevisiae Proteins; Valproic Acid; Yeasts	2009
Ethylbutyrate, a valproate-like compound, exhibits inositol-depleting effects--a potential mood-stabilizing drug. Life sciences, 2009, Jan-02, Volume: 84, Issue:1-2 Topics: Affect; Bipolar Disorder; Butyrates; Cell Proliferation; Humans; Inositol; Intramolecular Lyases; Saccharomyces cerevisiae; Valproic Acid	2009
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. Epilepsia, 2009, Volume: 50, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult	2009
PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers. Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 5 Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Chemotaxis; Humans; Inositol; Lithium Compounds; Phosphatidylinositol Phosphates; Signal Transduction; Valproic Acid	2009
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Disease models & mechanisms, 2012, Volume: 5, Issue:1 Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Inositol; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Rats; Signal Transduction; Time Factors; Valproic Acid	2012
Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease models & mechanisms, 2012, Volume: 5, Issue:2 Topics: Cell Line; Dictyostelium; Fatty Acids; Fatty Liver; Hepatocytes; Humans; Inositol; Kinetics; Lipid Metabolism; Models, Biological; Species Specificity; Teratogens; Valproic Acid	2012
Phosphorylation regulates myo-inositol-3-phosphate synthase: a novel regulatory mechanism of inositol biosynthesis. The Journal of biological chemistry, 2013, Sep-13, Volume: 288, Issue:37 Topics: Amino Acid Sequence; Binding Sites; Catalysis; Escherichia coli; Gene Expression Regulation, Enzymologic; Humans; Inositol; Intramolecular Lyases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phospholipids; Phosphoproteins; Phosphorylation; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Valproic Acid	2013
Inositol synthesis regulates the activation of GSK-3α in neuronal cells. Journal of neurochemistry, 2015, Volume: 133, Issue:2 Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Glycogen Synthase Kinase 3; Heat-Shock Proteins; Humans; Inositol; Intracellular Fluid; Intramolecular Lyases; Neuroblastoma; RNA, Messenger; Symporters; Valproic Acid	2015
Perturbation of the Vacuolar ATPase: A NOVEL CONSEQUENCE OF INOSITOL DEPLETION. The Journal of biological chemistry, 2015, Nov-13, Volume: 290, Issue:46 Topics: Anticonvulsants; Drug Resistance, Fungal; Gene Deletion; Homeostasis; Inositol; Intramolecular Lyases; Myo-Inositol-1-Phosphate Synthase; Osmotic Pressure; Phosphatidylinositol Phosphates; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vacuolar Proton-Translocating ATPases; Vacuoles; Valproic Acid	2015
Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine. The Journal of biological chemistry, 2017, 03-24, Volume: 292, Issue:12 Topics: Acetyltransferases; Antimanic Agents; Bipolar Disorder; Ceramides; Down-Regulation; Humans; Inositol; Membrane Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Up-Regulation; Valproic Acid	2017
MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate. PloS one, 2017, Volume: 12, Issue:8 Topics: Antimanic Agents; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Inositol; Myo-Inositol-1-Phosphate Synthase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Valproic Acid	2017
In-silico studies on Myo inositol-1-phosphate synthase of Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:8 Topics: Animals; Inositol; Leishmania donovani; Leishmaniasis; Ligands; Mammals; Molecular Dynamics Simulation; Myo-Inositol-1-Phosphate Synthase; Valproic Acid	2022
Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase. The Journal of biological chemistry, 2022, Volume: 298, Issue:9 Topics: AMP-Activated Protein Kinases; Animals; Fibroblasts; Glucose; Humans; Inositol; Lithium; Mammals; Mice; Phosphatidic Acids; Phospholipase D; Phosphotransferases (Phosphate Group Acceptor); Valproic Acid	2022
Safety of inositol supplementation in patients taking lithium or valproic acid: a pilot clinical study. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:19 Topics: Adolescent; Adult; Dietary Supplements; Glucose; Humans; Inositol; Insulin; Lactalbumin; Lithium; Pilot Projects; Quality of Life; Thyrotropin; Triglycerides; Valproic Acid	2022