Compounds > valproic acid

valproic acid and imipenem, anhydrous

valproic acid has been researched along with imipenem, anhydrous in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Izumi, M; Saito, F; Takiguchi, Y; Torii, M; Yokota, M1
Kiribayashi, Y; Maeda, Y; Murakami, T; Nagai, J; Omoda, K; Takano, M; Yumoto, R1
Joo, JY; Kim, JH; Kwon, OH; Lee, SG1
Hsiao, FY; Pai, TY; Shen, LJ; Wu, CC; Wu, FL1

Other Studies

7 other study(ies) available for valproic acid and imipenem, anhydrous

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:6

    Topics: Administration, Oral; Animals; Anticonvulsants; Biological Transport, Active; Drug Interactions; Imipenem; Infusions, Intravenous; Intestinal Absorption; Male; Rats; Rats, Sprague-Dawley; Thienamycins; Valproic Acid

2001
Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:8

    Topics: Adult; Animals; Anticonvulsants; Area Under Curve; Carbapenems; Drug Interactions; Erythrocytes; Female; Humans; Imipenem; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Thienamycins; Time Factors; Valproic Acid

2005
[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics].
    The Korean journal of laboratory medicine, 2007, Volume: 27, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Thienamycins; Valproic Acid

2007
The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations.
    Therapeutic drug monitoring, 2016, Volume: 38, Issue:5

    Topics: Anti-Bacterial Agents; Anticonvulsants; beta-Lactams; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Interactions; Ertapenem; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Valproic Acid

2016