valproic acid has been researched along with homocysteine in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 18 (48.65) | 29.6817 |
| 2010's | 14 (37.84) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Hishida, R; Nau, H | 1 |
| Achón, M; Alonso-Aperte, E; Pérez-Miguelsanz, J; Ubeda, N; Varela-Moreiras, G | 1 |
| Fiehn, W; Kohl, B; Rieser, PA; Ringleb, P; Schwaninger, M; Walter-Sack, I; Winter, R | 1 |
| Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Chiarelli, F; Giuva, T; Morgese, G; Pascarella, R; Trotta, D; Verrotti, A | 1 |
| Artuch, R; Cardo, E; Colomé, C; Farré, C; Monrós, E; Pineda, M; Valls, C; Vilaseca, MA | 1 |
| Alonso-Aperte, E; Ubeda, N; Varela-Moreiras, G | 1 |
| Karabiber, H; Otlu, B; Ozerol, E; Sonmezgoz, E; Yakinci, C; Yologlu, S | 1 |
| Gidal, BE; Hammer, A; Tamura, T; Vuong, A | 1 |
| Coker, I; Karaguzel, O; Ozdamar, O; Sener, U; Topbas, M; Zorlu, Y | 1 |
| Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M | 1 |
| Attilakos, A; Garoufi, A; Katsarou, E; Mastroyianni, S; Papakonstantinou, E; Schulpis, K; Voudris, K | 1 |
| Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E | 1 |
| Kurul, S; Unalp, A; Yiş, U | 1 |
| Akin, R; Demirkaya, E; Gokçay, E; Gul, D; Kul, M; Unay, B; Vurucu, S | 1 |
| Gupta, S; Kruger, WD; Leclerc, D; Roy, M; Rozen, R; Wu, Q | 1 |
| Akar, N; Deda, G; Ertem, M; Teber, S; Unal, O | 1 |
| Belcastro, V; Striano, P | 1 |
| Arhan, E; Guven, A; Köse, G; Ozaydin, E; Sayli, TR; Unal, B | 1 |
| Bek, S; Cakir, E; Gökçil, Z; Odabaşi, Z; Oz, O | 1 |
| Dorszewska, J; Kaczmarek, I; Sniezawska, A; Steinborn, B; Winczewska-Wiktor, A | 1 |
| Aydogdu, SD; Colak, O; Dinleyici, EC; Ozdemir, O; Yakut, A; Yarar, C | 1 |
| Hsieh, CL; Peng, CC; Peng, RY; Tsai, WJ; Wang, HE | 1 |
| Chan, SH; Chang, CC; Chang, WN; Chen, SD; Chuang, HY; Chuang, YC; Huang, CR; Lin, TK; Lu, CH; Tan, TY | 1 |
| Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D | 1 |
| Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A | 1 |
| Keenan, N; Sadlier, LG; Wiltshire, E | 1 |
| Chen, Y; Chen, Z; Fang, Z; Ni, G; Qin, J; Zhou, J; Zhou, L | 1 |
| Chen, Y; Chen, Z; Fang, Z; Huang, M; Li, H; Ni, G; Qin, J; Zhou, J; Zhou, L; Zhou, Y | 1 |
| Sharma, TK; Sitaraman, S; Vardey, SK | 1 |
| Bigler, L; Bleul, C; Blom, H; Frisch, C; Linnebank, M; Prost, JC; Semmler, A; Smith, D | 1 |
| Gao, T; Gu, J; Guo, X; Li, D; Li, J; Li, K | 1 |
| Ali, N; Nazish, H; Shakir, S | 1 |
| Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J | 1 |
| Chen, D; Chen, L; Chen, P; Gao, X; Li, C; Li, H; Li, Y; Tian, Q; Tian, X; Wen, J; Yang, H; Zhang, M | 1 |
| Cui, YX; Dong, WC; Feng, JY; Guo, JL; Jiang, Y; Wu, XK; Zhang, CX; Zhang, ZQ; Zhao, MQ | 1 |
| Abd El Hady, NMS; Abdallah, HM; Abdelmageed, SM; Aboelghar, HM; Garib, MI; Mahmoud, AA | 1 |
3 review(s) available for valproic acid and homocysteine
| Article | Year |
|---|---|
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase; Valproic Acid | 2009 |
Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis.
Topics: Anticonvulsants; Epilepsy; Homocysteine; Humans; Valproic Acid | 2014 |
CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients.
Topics: Anticonvulsants; Carbamoyl-Phosphate Synthase (Ammonia); Case-Control Studies; Cholesterol, HDL; Epilepsy; Homocysteine; Humans; Hyperammonemia; Kidney; Polymorphism, Genetic; Risk Factors; Valproic Acid | 2019 |
2 trial(s) available for valproic acid and homocysteine
| Article | Year |
|---|---|
Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Epilepsy; Female; Homocysteine; Humans; Male; Valproic Acid | 2000 |
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Valproic Acid; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
32 other study(ies) available for valproic acid and homocysteine
| Article | Year |
|---|---|
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1998 |
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation.
Topics: Analysis of Variance; Animals; Female; Folic Acid; Gestational Age; Homocysteine; Methionine; Methylation; Rats; Rats, Wistar; Valproic Acid | 1999 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1999 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Valproic Acid | 2000 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Valproic Acid; Vitamin B 12 | 2003 |
Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy.
Topics: Adult; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Male; Middle Aged; Triazines; Valproic Acid; Vitamin B 12 | 2005 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Pyridoxal Phosphate; Reference Values; Valproic Acid; Vitamin B 12 | 2006 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12 | 2006 |
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Pyridoxal Phosphate; Valproic Acid; Vitamin B 12 | 2006 |
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Valproic Acid; Vitamin B 12; Vitamin B 6 | 2007 |
Homocysteine levels in epileptic children receiving antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Oxcarbazepine; Valproic Acid; Vitamin B 12 | 2007 |
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Electrochemistry; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Valproic Acid; Vitamin B 12 | 2008 |
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cell Line, Tumor; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Pregnancy; Teratogens; Up-Regulation; Valproic Acid | 2008 |
Thrombophilic risk factors in epileptic children treated with valproic Acid.
Topics: Adolescent; Anticonvulsants; Antithrombin III; Blood Coagulation Factors; Child; Child, Preschool; Epilepsy; Female; Fibrinogen; Homocysteine; Humans; Infant; Lipoprotein(a); Male; Protein C; Protein S; Prothrombin; Risk Factors; Thrombophilia; Valproic Acid | 2009 |
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".
Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Arteriosclerosis; Lipid Metabolism Disorders; Risk Factors; Tunica Intima; Valproic Acid | 2009 |
Valproate-associated coagulopathies in children during short-term treatment.
Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Protein Disorders; Child; Child, Preschool; Down-Regulation; Drug Administration Schedule; Epilepsy; Factor VII; Factor VIII; Female; Fibrinogen; Homocysteine; Humans; Lipoprotein(a); Male; Platelet Count; Prospective Studies; Protein C; Valproic Acid | 2009 |
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12 | 2009 |
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex | 2011 |
Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Chick Embryo; Chromatography, High Pressure Liquid; Folic Acid; Foot Deformities; Glutathione; Hindlimb; Histone Deacetylases; Homocysteine; Hydrogen Peroxide; Joints; Muscle, Skeletal; Neovascularization, Physiologic; Superoxide Dismutase; Teratogens; Tissue Embedding; Valproic Acid; Vitamins | 2012 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Artery, Common; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Uric Acid; Valproic Acid; Young Adult | 2012 |
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; Female; Homocysteine; Humans; Male; Nitric Oxide; Oxcarbazepine; Prospective Studies; Risk Factors; Valproic Acid | 2013 |
Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Aorta; Blood Glucose; Brachial Artery; Carbamazepine; Carotid Arteries; Cholesterol; Cholesterol, HDL; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phosphoric Monoester Hydrolases; Risk Factors; Ultrasonography; Valproic Acid; Vitamin B 12 | 2014 |
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Cross-Sectional Studies; DNA Methylation; Epilepsy; Female; Folic Acid; Heterocyclic Compounds; Homocysteine; Humans; Lamotrigine; Long Interspersed Nucleotide Elements; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Triazines; Valproic Acid; Vitamin B 12; Young Adult | 2015 |
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children.
Topics: Adolescent; Age Factors; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Time Factors; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2015 |
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Astrocytes; Cell Count; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Female; Folic Acid; Hippocampus; Homocysteine; Liver; Male; Neurogenesis; Neurons; Organ Size; Rats, Wistar; Valproic Acid | 2017 |
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic Acid; Homocysteine; Humans; Male; Mice; Mice, Inbred ICR; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid | 2018 |
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Seizures; Severity of Illness Index; Treatment Outcome; Valproic Acid; Vitamin B 6; Young Adult | 2018 |
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Animal; Female; Homocysteine; Mice; Mice, Inbred ICR; Pregnancy; Prenatal Exposure Delayed Effects; Protective Agents; Social Behavior; Valproic Acid | 2019 |
A simple and accurate HFCF-UF method for the analysis of homocysteine, cysteine, cysteinyl-glycine, and glutathione in human blood.
Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme Inhibitors; Freezing; Glutathione; Homocysteine; Humans; Limit of Detection; Methotrexate; Molecular Structure; Tandem Mass Spectrometry; Temperature; Ultrafiltration; Valproic Acid; Vancomycin | 2021 |
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Levetiracetam; Valproic Acid | 2022 |