valproic acid and glycine

valproic acid has been researched along with glycine in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (59.18)	18.7374
1990's	13 (26.53)	18.2507
2000's	2 (4.08)	29.6817
2010's	3 (6.12)	24.3611
2020's	2 (4.08)	2.80

Authors

Authors	Studies
Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Koella, WP; Olpe, HR; Schmutz, M	1
Carchon, H; Casaer, P; Corbeel, L; Eeckels, R; Eggermont, E; Jaeken, J	1
Bartlett, K	1
Wolf, B	1
Charpentier, C; Cherruau, B; Demelier, JF; Lemonnier, A; Mangeot, M; Pelletier, C	2
Hartikainen-Sorri, AL; Kääpä, P; Saukkonen, AL; Similä, S; von Wendt, L	1
Debray-Ritzen, P; Kamoun, P; Parvy, P	1
Stone, WE	1
Kamoun, P; Parvy, P	1
Bergey, GK; Macdonald, RL	1
Huhtaniemi, I; Linna, SL; Saukkonen, AL; Similä, S; von Wendt, L	1
Hayasaka, K; Hiraga, K; Kikuchi, G; Kochi, H	1
Mori, A; Shiraga, H; Watanabe, Y	1
Davis, BA; Yu, PH	3
Maheshwari, MC; Selvamurthy, W; Sharma, SK; Singh, TP	1
Chung, EY; Rosenbaum, D; Van Woert, MH	1
Chung, EY; Van Woert, MH	1
Bhargava, KP; Gupta, GP; Gupta, MB	1
Meldrum, BS	1
Chapman, AG	1
Kolokouris, N; Vamvakidès, A	1
Benavides, J; Lopez, M; Martin-Gallardo, A; Rodriguez, P; Ugarte, M	1
Casaer, P; Corbeel, L; Jaeken, J	1
Bruni, J; Hammond, EJ; Wilder, BJ	1
Chapman, AG; Meldrum, BS	1
Applegarth, DA; Farrell, K; Kirby, LT; Verity, CM	1
Lajtha, A; Toth, E	1
MacDermot, K; Nelson, W; Schulman, JD; Weinberg, JA	1
Christensen, E; Kølvraa, S; Mortensen, PB	1
Kerwin, RW; Olpe, HR; Schmutz, M	1
Benavides, J; Martín, A; Ugarte, M	1
Bialer, M; Hadad, S	1
Cantello, R; Gianelli, M; Monaco, F; Mutani, R; Naldi, P; Schiavella, MP; Torta, R; Verzé, L	1
Fekete, T; Gregus, Z; Klaassen, CD; Varga, F	1
Abdul-Hai, A; Bialer, M; Haj-Yehia, A; Herzig, Y; Kadry, B; Shirvan, M; Sterling, J	1
Alexiuk, NA; Vriend, JP	1
Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M	1
Bialer, M	1
Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M	1
Bergh, JJ; Kotze, HF; Mienie, LJ; Terre'Blanche, G; Viljoen, J	1
Kanbur, E; Stanley, BA; Tümer, E; Yerlikaya, A	1
Aamir, M; Ahmad, S; Haroon, ZH; Khalid, UB; Kirmani, SI; Munir, MU	1

Reviews

5 review(s) available for valproic acid and glycine

Article	Year
Drugs acting on amino acid neurotransmitters. Advances in neurology, 1986, Volume: 43 Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid	1986
Valproate and myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid	1986
Central actions of valproic acid in man and in experimental models of epilepsy. Life sciences, 1981, Dec-21, Volume: 29, Issue:25 Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Aspartic Acid; Brain; Cyclic GMP; Dyskinesia, Drug-Induced; Electric Stimulation; Electrophysiology; Epilepsies, Partial; gamma-Aminobutyric Acid; Glycine; Humans; Nervous System Diseases; Neurons; Seizures; Serotonin; Succinate-Semialdehyde Dehydrogenase; Succinates; Valproic Acid	1981
Effects of anticonvulsant drugs on brain amino acid metabolism. Progress in clinical and biological research, 1983, Volume: 124 Topics: 4-Aminobutyrate Transaminase; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Benzodiazepines; Biomechanical Phenomena; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Glutamates; Glycine; Humans; Neural Inhibition; Phenobarbital; Synapses; Valproic Acid	1983
The Ubiquitin-Proteasome Pathway and Epigenetic Modifications in Cancer. Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:1 Topics: Acetylation; Boron Compounds; Bortezomib; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Glycine; Histone Acetyltransferases; Histone Deacetylases; Humans; Hydroxamic Acids; Methylation; Neoplasms; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Signal Transduction; Terphenyl Compounds; Ubiquitin; Ubiquitination; Valproic Acid	2021

Other Studies

44 other study(ies) available for valproic acid and glycine

Article	Year
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1 Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Esters; Glycine; Male; Mice; Mice, Inbred Strains; Neurotoxins; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glycine; Seizures; Spinal Cord; Strychnine	1998
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Central actions of valproate sodium. The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:6 Topics: Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Glycine; Neurons; Rats; Substantia Nigra; Time Factors; Valproic Acid	1979
Dipropylacetate (valproate) and glycine metabolism. Lancet (London, England), 1977, Sep-17, Volume: 2, Issue:8038 Topics: Epilepsy; Glycine; Humans; Infant; Valerates; Valproic Acid	1977
Sodium valproate and hyperglycinaemia. Lancet (London, England), 1977, Oct-01, Volume: 2, Issue:8040 Topics: Acetyltransferases; Glycine; Valerates; Valproic Acid	1977
Dipropylacetate and propionyl CoA carboxylase. Lancet (London, England), 1978, Aug-12, Volume: 2, Issue:8085 Topics: Carboxy-Lyases; Glycine; Humans; Valerates; Valproic Acid	1978
[Propionic acidemia and sodium dipropylacetate]. Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles, 1979, Sep-24, Volume: 289, Issue:5 Topics: Acyl Coenzyme A; Animals; Biotin; Blood Glucose; Glycine; Ligases; Liver; Male; Propionates; Rats; Valproic Acid	1979
Sodium valproate, pregnancy, and neonatal hyperglycinaemia. Archives of disease in childhood, 1979, Volume: 54, Issue:12 Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pregnancy Complications; Valproic Acid	1979
[Hyperglycinuria induced by n-dipropylacetate. Possible model of propionic acidemia]. La Nouvelle presse medicale, 1977, Jun-11, Volume: 6, Issue:24 Topics: Child; Child, Preschool; Glycine; Humans; Infant; Metabolic Diseases; Models, Biological; Propionates; Valerates; Valproic Acid	1977
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies. Epilepsia, 1977, Volume: 18, Issue:4 Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid	1977
[Effect of n-dipropyl-acetate on the elimination of urinary amino acids]. Helvetica paediatrica acta, 1978, Volume: 33, Issue:4-5 Topics: Alanine; Amino Acids; Child; Glutamates; Glutamine; Glycine; Histidine; Humans; Male; Ornithine; Serine; Valproic Acid	1978
Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Brain research, 1979, Jul-20, Volume: 170, Issue:3 Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamates; Glycine; Mice; Neural Inhibition; Neurons; Spinal Cord; Synapses; Valproic Acid	1979
Dipropylacetate and hyperglycinemia. Neuropadiatrie, 1979, Volume: 10, Issue:2 Topics: Adolescent; Child; Epilepsy; Glycine; Humans; Valproic Acid	1979
Reduction of the level of the glycine cleavage system in the rat liver resulting from administration of dipropylacetic acid: an experimental approach to hyperglycinemia. Archives of biochemistry and biophysics, 1979, Volume: 198, Issue:2 Topics: Animals; Glycine; Mitochondria, Liver; Proteins; Rats; Succinates; Valproic Acid	1979
Guanidino compound levels in the serum of healthy adults and epileptic patients. Epilepsy research, 1991, Volume: 8, Issue:2 Topics: Adult; Arginine; Creatinine; Epilepsy; Female; Glycine; Guanidines; Homoarginine; Humans; Male; Phenanthrenes; Sex Factors; Valproic Acid	1991
Simultaneous delivery of valproic acid and glycine to the brain. Deamination of 2-propylpentylglycinamide by monoamine oxidase B. Molecular and chemical neuropathology, 1991, Volume: 15, Issue:1 Topics: Animals; Brain; Deamination; Glycine; In Vitro Techniques; Kinetics; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Prodrugs; Rats; Tremor; Valproic Acid	1991
Deamination of 2-propyl-1-aminopentane and 2-[(2-propyl)pentylamino] acetamide by amine oxidases: formation of valproic acid. Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:2 Topics: Amine Oxidase (Copper-Containing); Amines; Animals; Behavior, Animal; Brain; Deamination; Glycine; Hydrogen Peroxide; In Vitro Techniques; Liver; Mice; Monoamine Oxidase; Rats; Valproic Acid	1991
Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis. The Indian journal of medical research, 1990, Volume: 92 Topics: Age Factors; Animals; Cerebellum; Electroencephalography; Glycine; Hippocampus; Kainic Acid; Nutrition Disorders; Rats; Seizures; Spinal Cord; Valproic Acid	1990
Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-propyl-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors. Journal of neural transmission. Supplementum, 1990, Volume: 32 Topics: 3-Mercaptopropionic Acid; Amine Oxidase (Copper-Containing); Amines; Animals; Anticonvulsants; Deamination; Fluorometry; Glycine; In Vitro Techniques; Mitochondria, Liver; Monoamine Oxidase; Prodrugs; Rats; Valproic Acid	1990
Biochemistry and therapeutics of posthypoxic myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Humans; Hydroxyindoleacetic Acid; Hypoxia; Methysergide; Models, Biological; Myoclonus; Prednisone; Serotonin; Tryptophan; Valproic Acid	1986
Possible mechanisms of action of valproic acid in myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 4-Aminobutyrate Transaminase; 5-Hydroxytryptophan; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Hydroxyindoleacetic Acid; Myoclonus; Pyridoxal Kinase; Rats; Serotonin; Tryptophan; Valproic Acid	1986
Central GABA-ergic mechanism in stress-induced gastric ulceration. British journal of pharmacology, 1985, Volume: 84, Issue:3 Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Neurotransmitter Agents; Picrotoxin; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Valproic Acid	1985
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide]. Annales pharmaceutiques francaises, 1986, Volume: 44, Issue:6 Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid	1986
Effects of dipropylacetate on the glycine cleavage enzyme system and glycine levels. A possible experimental approach to non-ketotic hyperglycinemia. Biochemical pharmacology, 1985, Aug-15, Volume: 34, Issue:16 Topics: Age Factors; Animals; Brain; Glycine; Mitochondria, Liver; Rats; Rats, Inbred Strains; Spinal Cord; Valproic Acid	1985
Valproate, hyperammonaemia, and hyperglycinaemia. Lancet (London, England), 1980, Aug-02, Volume: 2, Issue:8188 Topics: Ammonia; Animals; Glycine; Humans; Rats; Sleep Stages; Valproic Acid	1980
The influence of anticonvulsants on fasting plasma ammonia and amino acid levels. Clinical biochemistry, 1983, Volume: 16, Issue:6 Topics: Amino Acids; Ammonia; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Glutamine; Glycine; Humans; Infant; Ornithine; Phenobarbital; Valproic Acid	1983
Glycine potentiates the action of some anticonvulsant drugs in some seizure models. Neurochemical research, 1984, Volume: 9, Issue:12 Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Glycine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Valproic Acid	1984
Valproate in nonketotic hyperglycinemia. Pediatrics, 1980, Volume: 65, Issue:3 Topics: Glycine; Humans; Valproic Acid	1980
Inhibition of the glycine cleavage system: hyperglycinemia and hyperglycinuria caused by valproic acid. Epilepsia, 1980, Volume: 21, Issue:6 Topics: Animals; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Glycine; Humans; Infant; Liver; Mitochondria, Liver; Rats; Valproic Acid	1980
The effect of sodium-n-dipropyl acetate on gamma-aminobutyric acid-dependent inhibition in the rat cortex and substantia nigra in relation to its anticonvulsant activity. British journal of pharmacology, 1980, Volume: 71, Issue:2 Topics: Animals; Anticonvulsants; Cerebral Cortex; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Muscimol; Neurons; Rats; Substantia Nigra; Time Factors; Valproic Acid	1980
Metabolic abnormalities observed in the rat after administration of sodium dipropylacetate. Toxicology letters, 1981, Volume: 8, Issue:1-2 Topics: Animals; Biotin; Carboxy-Lyases; Glycine; Male; Methylmalonyl-CoA Decarboxylase; Propionates; Rats; Valproic Acid	1981
[Inhibition by dipropyl acetate and its structural analogs of the glycine synthase system in liver and brain mitochondria]. Revista espanola de fisiologia, 1982, Volume: 38 Suppl Topics: Amino Acid Oxidoreductases; Animals; Anticonvulsants; Brain; Carrier Proteins; Epilepsy; Glycine; Male; Mitochondria; Mitochondria, Liver; Multienzyme Complexes; Rats; Rats, Inbred Strains; Transferases; Valproic Acid	1982
Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine. Pharmaceutical research, 1995, Volume: 12, Issue:6 Topics: Animals; Anticonvulsants; Dogs; Female; gamma-Aminobutyric Acid; Glycine; Injections, Intravenous; Male; Time Factors; Valproic Acid	1995
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives. Italian journal of neurological sciences, 1994, Volume: 15, Issue:3 Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taurine; Valproic Acid	1994
Effect of valproic acid on glycine conjugation of benzoic acid. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: Animals; Anticonvulsants; Benzoates; Benzoic Acid; Fatty Acids, Monounsaturated; Glycine; Hippurates; Kidney; Liver; Male; Rats; Rats, Wistar; Valproic Acid	1993
Pharmacokinetic and pharmacodynamic analysis of (E)-2-ene valproyl derivatives of glycine and valproyl derivatives of nipecotic acid. Biopharmaceutics & drug disposition, 1996, Volume: 17, Issue:7 Topics: Animals; Anticonvulsants; Dogs; Drug Stability; Glycine; Mice; Nipecotic Acids; Rats; Species Specificity; Structure-Activity Relationship; Valproic Acid	1996
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. Molecular and chemical neuropathology, 1996, Volume: 27, Issue:3 Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; Disease Susceptibility; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Homovanillic Acid; Hydroxyindoleacetic Acid; Mesencephalon; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Species Specificity; Tyrosine 3-Monooxygenase; Valproic Acid	1996
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. Revista de neurologia, 1997, Volume: 25, Issue:143 Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glutamine; Glycine; Humans; Infant; Infant, Newborn; Ornithine; Prospective Studies; Retrospective Studies; Urea; Valproic Acid	1997
Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs. Journal of controlled release : official journal of the Controlled Release Society, 1999, Nov-01, Volume: 62, Issue:1-2 Topics: Amides; Animals; Anticonvulsants; Biotransformation; Cyclopropanes; Dogs; Drug Design; Glycine; Mice; Rats; Rats, Sprague-Dawley; Valproic Acid	1999
Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3 Topics: Animals; Anticonvulsants; Brain Chemistry; Central Nervous System Stimulants; Creatine; Dextroamphetamine; Glucose-6-Phosphate; Glycine; Inositol; Inositol Phosphates; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Valproic Acid	2003
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate. Metabolic brain disease, 2012, Volume: 27, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Chlorocebus aethiops; Disease Models, Animal; Female; Glycine; Hyperglycinemia, Nonketotic; Male; Pilot Projects; Valproic Acid	2012
Association of Therapeutic Dose of Valproic Acid and Plasma Glycine Levels in Epileptic Patients. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021, Volume: 31, Issue:9 Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Glycine; Humans; Valproic Acid	2021