valproic acid has been researched along with glutamine in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (41.30) | 18.7374 |
| 1990's | 10 (21.74) | 18.2507 |
| 2000's | 11 (23.91) | 29.6817 |
| 2010's | 5 (10.87) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ciccone, A; Cocchi, R; Mastruzzo, A; Osvaldi, ML | 1 |
| Cocchi, R; Fusari, A; Lorini, G; Roccia, L | 1 |
| Cocchi, R; Tornati, A | 1 |
| Kamoun, P; Parvy, P | 1 |
| Cocchi, R; Favuto, F; Fusari, A; Lorini, G | 1 |
| Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB | 1 |
| Baverel, G; Durozard, D; Martin, G | 1 |
| Baverel, G; Besson, J; Durozard, D; Martin, G | 1 |
| Culebras, M; Doval, M; Gougoux, A; Lopez-Farré, A; Lopez-Novoa, JM; Rengel, M; Vinay, P | 1 |
| Gougoux, A; Vinay, P | 1 |
| Alonso, E; García-España, A; Girbés, J; Rubio, V | 1 |
| Cremel, G; Marescaux, C; Rumbach, L; Waksman, A; Warter, JM | 1 |
| Baverel, G; Martin, G; Michoudet, C | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Chabrier, G; Imler, M; Marescaux, C; Warter, JM | 1 |
| Casaer, P; Corbeel, L; Jaeken, J | 1 |
| Culebras, M; Doval, M; Gougoux, A; López-Novoa, JM; Rengel, M; Vinay, P | 1 |
| Goto, S; Ichikawa, M; Matsuyama, K; Miyazaki, C | 1 |
| Chabrier, G; Imler, M; Krieger, J; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM | 1 |
| Applegarth, DA; Farrell, K; Kirby, LT; Verity, CM | 1 |
| Chabrier, G; Collard, M; Imler, M; Koehl, C; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM | 1 |
| Chabrier, G; Imler, M; Marescaux, C; Micheletti, B; Rumbach, L; Warter, JM | 1 |
| Biggs, CS; Fowler, LJ; Pearce, BR; Whitton, PS | 1 |
| Alexiuk, NA; Vriend, JP | 1 |
| Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M | 1 |
| Abbott, FS; Palaty, J; Tang, W | 1 |
| Barros, HM; Tannhauser, M; Vargas, C | 1 |
| Behar, KL; Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL | 1 |
| Nikiforov, AA; Ostretsova, IB; Zagryadskaya, EI | 1 |
| Blüml, S; Moreno-Torres, A; Nguy, CH; Ross, BD; Shic, F | 1 |
| Cawthon, DF; Caylor, LM; Kraemer, DL; Morgan, JD; Ojemann, LM; Vossler, DG; Wilensky, AJ | 1 |
| Klisch, J; Schumacher, M; Spreer, J; Thiel, T; Ziyeh, S | 1 |
| Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ | 2 |
| Gao, Y; Lei, LS; Wu, SG | 1 |
| Baverel, G; Gauthier, C; Michoudet, C; Vittorelli, A | 1 |
| Dager, SR; Demopulos, C; Dunner, DL; Friedman, SD; Hirashima, F; Lyoo, IK; Parow, A; Renshaw, PF; Stoll, AL | 1 |
| Baverel, G; Gauthier, C; Martin, G; Michoudet, C; Vittorelli, A | 1 |
| Puente, V; Rodriguez-Campello, A; Roquer, J; Segura-Bruna, N | 1 |
| Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S | 1 |
| Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ | 1 |
| Correa-Basurto, J; Fragoso-Vázquez, MJ; Luna-Palencia, GR; Martínez-Ramos, F; Méndez-Luna, D; Mendieta-Wejebe, JE; Meraz-Ríos, MA; Trujillo-Ferrara, J; Vásquez-Moctezuma, I | 1 |
| Jahan, K; Pillai, KK; Vohora, D | 1 |
| Correa-Basurto, J; Estrada-Pérez, A; Fragoso-Vázquez, MJ; Fromager, B; Luna-Palencia, GR; Méndez-Luna, D; Rosales-Hernández, MC; Vásquez-Moctezuma, I | 1 |
2 review(s) available for valproic acid and glutamine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Brain; Brain Edema; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carnitine; Diagnosis, Differential; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Valproic Acid | 2006 |
4 trial(s) available for valproic acid and glutamine
| Article | Year |
|---|---|
[1-glutamine and dipropylacetic acid as subsidiary psychotropic agents in the treatment of psychiatric in-patients. Effect on the neuroleptic consumption].
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Female; Glutamine; Humans; Tranquilizing Agents; Valerates; Valproic Acid | 1977 |
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.
Topics: Adult; Ammonia; Anticonvulsants; Astrocytes; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Occipital Lobe; Refractory Period, Electrophysiological; Valproic Acid | 1999 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid | 2003 |
Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder.
Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Brain Mapping; Case-Control Studies; Echo-Planar Imaging; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Lactic Acid; Lithium; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Valproic Acid | 2004 |
40 other study(ies) available for valproic acid and glutamine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[Acupunctura, "vital" drugs and psychopharmacological agents in the treatment of psychiatric patients with deep depressive disorders, with considerations on the probable neurophysiological mechanisms of the synergism of action].
Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Female; Glutamine; Humans; Male; Mental Disorders; Middle Aged; Psychotropic Drugs; Valerates; Valproic Acid | 1977 |
[Psychological dependence? A possible different formulation of the problem for a therapeutic rearrangement in chronic drug addictions].
Topics: Antidepressive Agents; gamma-Aminobutyric Acid; Glutamine; Humans; Piracetam; Substance-Related Disorders; Valproic Acid | 1977 |
[Effect of n-dipropyl-acetate on the elimination of urinary amino acids].
Topics: Alanine; Amino Acids; Child; Glutamates; Glutamine; Glycine; Histidine; Humans; Male; Ornithine; Serine; Valproic Acid | 1978 |
[Acupuncture, "vital" drugs and psychotropic agents in psychiatric patients. 50 cases].
Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Drug Evaluation; Evaluation Studies as Topic; Female; Glutamine; Humans; Male; Mental Disorders; Middle Aged; Psychotropic Drugs; Time Factors; Valproic Acid | 1978 |
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia); Coma; Corpus Callosum; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy, Generalized; Female; Glutamine; Humans; Phenytoin; Tomography, X-Ray Computed; Valproic Acid | 1992 |
Valproate-induced alterations of coenzyme A and coenzyme A ester concentrations in human kidney tubules metabolizing glutamine.
Topics: Acetyl Coenzyme A; Adult; Ammonia; Coenzyme A; Glutamine; Humans; In Vitro Techniques; Kidney Tubules; Valproic Acid | 1991 |
Effect of the antiepileptic drug sodium valproate on glutamine and glutamate metabolism in isolated human kidney tubules.
Topics: Adult; Ammonia; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Humans; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Stimulation, Chemical; Valproic Acid | 1990 |
Effect of valproate on lactate and glutamine metabolism by rat renal cortical tubules.
Topics: Animals; Drug Combinations; Glutamine; Kidney Cortex; Kidney Tubules; Kidney Tubules, Collecting; Lactates; Oxygen Consumption; Rats; Rats, Inbred Strains; Valproic Acid | 1989 |
Metabolic effects of valproate on dog renal cortical tubules.
Topics: Aminooxyacetic Acid; Animals; Dogs; Glutamates; Glutamine; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Lactates; Oxygen Consumption; Pyruvates; Valproic Acid | 1989 |
Changes in urea cycle-related metabolites in the mouse after combined administration of valproic acid and an amino acid load.
Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Citrulline; Glutamates; Glutamine; Liver; Mice; Ornithine; Urea; Valproic Acid | 1989 |
Valproate-induced hyperammonemia of renal origin. Effects of valproate on glutamine transport in rat kidney mitochondria.
Topics: Ammonia; Animals; Binding, Competitive; Biological Transport; Glutamine; Kidney; Kinetics; Male; Mitochondria; Rats; Rats, Inbred Strains; Valproic Acid | 1989 |
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid | 1989 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Effects of 2,4-dinitrophenol on renal ammoniagenesis in the rat.
Topics: 2,4-Dinitrophenol; Ammonia; Animals; Biological Transport, Active; Dinitrophenols; Glutamine; Kidney; Male; Rats; Rats, Inbred Strains; Valproic Acid | 1986 |
Valproate increases cerebrospinal fluid glutamine levels.
Topics: Animals; Child; Child, Preschool; Glutamine; Humans; Infant; Rats; Stimulation, Chemical; Valproic Acid | 1987 |
Ammoniagenesis and valproic acid in the rat in vivo: role of the kidney.
Topics: Ammonia; Animals; Glutamine; Kidney; Male; Rats; Rats, Inbred Strains; Valproic Acid | 1988 |
Effect of sodium valproate (VPA) on cerebral amino acids: mechanism of gamma-aminobutyric acid (GABA) elevation and possible causal relation of VPA-induced encephalopathy and glutamine level.
Topics: Amino Acids; Animals; Brain Chemistry; Brain Diseases; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Mice, Inbred Strains; Valproic Acid | 1988 |
Sodium valproate-induced hyperammonemia in the rat: role of the kidney.
Topics: Ammonia; Animals; Glutamine; Kidney; Male; Nephrectomy; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1983 |
The influence of anticonvulsants on fasting plasma ammonia and amino acid levels.
Topics: Amino Acids; Ammonia; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Glutamine; Glycine; Humans; Infant; Ornithine; Phenobarbital; Valproic Acid | 1983 |
[Role of hyperammonemia in stuporous states induced by sodium valproate].
Topics: Adult; Ammonia; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamine; Humans; Unconsciousness; Valproic Acid | 1983 |
[Renal glutamine metabolism in man during treatment with sodium valproate].
Topics: Adult; Ammonia; Female; Glutamine; Humans; Kidney; Male; Middle Aged; Valproic Acid | 1984 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid | 1994 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; Disease Susceptibility; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Homovanillic Acid; Hydroxyindoleacetic Acid; Mesencephalon; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Species Specificity; Tyrosine 3-Monooxygenase; Valproic Acid | 1996 |
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients].
Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glutamine; Glycine; Humans; Infant; Infant, Newborn; Ornithine; Prospective Studies; Retrospective Studies; Urea; Valproic Acid | 1997 |
Time course of alpha-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal gamma-aminobutyric acid levels in comparison to valproic acid.
Topics: Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Solubility; Synaptosomes; Valproic Acid | 1997 |
Dissimilar effects of lithium and valproic acid on GABA and glutamine concentrations in rat cerebrospinal fluid.
Topics: Animals; Antimanic Agents; Female; gamma-Aminobutyric Acid; Glutamine; Hyponatremia; Lithium Chloride; Rats; Rats, Wistar; Valproic Acid | 1998 |
Inhibitory effect of valproate on weak organic acid uptake in rat renal proximal tubules.
Topics: Ammonia; Animals; Anticonvulsants; Fluorescein; Glutamic Acid; Glutamine; Kidney Tubules, Proximal; Male; Rats; Rats, Wistar; Valproic Acid | 1999 |
Tricarboxylic acid cycle of glia in the in vivo human brain.
Topics: Acetates; Adult; Bicarbonates; Brain; Carbon Isotopes; Citric Acid Cycle; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroglia; Oxidation-Reduction; Valproic Acid | 2002 |
Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Brain; Brain Diseases; Electroencephalography; Female; Glutamine; Humans; Hyperammonemia; Male; Middle Aged; Valproic Acid | 2002 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid | 2002 |
[Effects of chronic valproic acid sodium treatment and withdrawal on glutamate and glutamine release of C6 glioma cells].
Topics: Anticonvulsants; Glioma; Glutamic Acid; Glutamine; Humans; Time Factors; Tumor Cells, Cultured; Valproic Acid | 2003 |
Metabolic viability and pharmaco-toxicological reactivity of cryopreserved human precision-cut renal cortical slices.
Topics: Adenosine Triphosphate; Carbon Radioisotopes; Cell Survival; Cryopreservation; Glutamine; Humans; In Vitro Techniques; Kidney Cortex; L-Lactate Dehydrogenase; Proteins; Time Factors; Valproic Acid | 2004 |
Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13C-NMR study.
Topics: Ammonia; Carbon Isotopes; Dose-Response Relationship, Drug; Glucose; Glutamine; Humans; Kidney; Lactic Acid; Magnetic Resonance Spectroscopy; Valproic Acid | 2005 |
The effect of sodium valproate on proton MRS visible neurochemical concentrations.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Valproic Acid | 2007 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult | 2009 |
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.
Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid | 2011 |
Docking Studies of Glutamine Valproic Acid Derivative (S)-5- amino-2-(heptan-4-ylamino)-5-oxopentanoic Acid (Gln-VPA) on HDAC8 with Biological Evaluation in HeLa Cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Glutamine; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Docking Simulation; Molecular Structure; Repressor Proteins; Structure-Activity Relationship; Valproic Acid | 2016 |
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Neurotransmitter Agents; Phenylalanine; Psychomotor Agitation; Seizures; Serotonin; Valproic Acid | 2017 |
Molecular modeling and LC-MS-based metabolomics of a glutamine-valproic acid (Gln-VPA) derivative on HeLa cells.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Chromatography, Liquid; Glutaminase; Glutamine; HeLa Cells; Humans; Mass Spectrometry; Metabolome; Metabolomics; Models, Molecular; Valproic Acid | 2021 |