valproic acid has been researched along with glutamic acid in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (12.35) | 18.7374 |
| 1990's | 14 (17.28) | 18.2507 |
| 2000's | 31 (38.27) | 29.6817 |
| 2010's | 21 (25.93) | 24.3611 |
| 2020's | 5 (6.17) | 2.80 |
| Authors | Studies |
|---|---|
| Amano, O; Izeki, S; Kido, Y; Ogihara, T; Ono, A; Sai, Y; Satoh, E; Takanaga, H; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ponchaut, S; van Hoof, F; Veitch, K | 1 |
| Hansson, E; Nilsson, M; Rönnbäck, L | 2 |
| Baverel, G; Martin, G; Michoudet, C | 1 |
| Bhargava, KP; Gupta, GP; Gupta, MB | 1 |
| Akhundov, RA; Rozhanets, VV; Val'dman, AV; Voronina, TA | 1 |
| Briand, P; Cathelineau, L; Kamoun, P; Petit, F; Rabier, D | 1 |
| Kent, AP; Webster, RA | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Davidoff, RA; Grayson, V; Hackman, JC | 1 |
| Baltassat, P; Cotte, J; Divry, P; Duran, M; Hermier, M; Rolland, MO; Wadman, SK | 1 |
| Geddes, JW; Wood, JD | 1 |
| Greenland, RD; Lasley, SM; Michaelson, IA | 1 |
| Biggs, CS; Fowler, LJ; Pearce, BR; Whitton, PS | 1 |
| Marsden, CA; Martin, KF; Rowley, HL | 1 |
| Adkison, KD; Shen, DD | 1 |
| Dixon, JF; Hokin, LE; Los, GV | 1 |
| Bock, I; Cseko, J; Farkas, V; Sandor, A | 1 |
| Dixon, JF; Hokin, LE | 1 |
| Alexiuk, NA; Vriend, JP | 1 |
| Behar, KL; Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL | 1 |
| Nikiforov, AA; Ostretsova, IB; Zagryadskaya, EI | 1 |
| Masereeuw, R; Russel, FG; Tanriseven, O; Terlouw, SA | 1 |
| Sethi, ML | 1 |
| Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I | 1 |
| Gjerstad, L; Hassel, B; Iversen, EG; Taubøll, E | 1 |
| Fonnum, F; Hassel, B; Johannessen, CU; Petersen, D | 1 |
| Blüml, S; Moreno-Torres, A; Nguy, CH; Ross, BD; Shic, F | 1 |
| Chuang, DM; Hashimoto, R; Hough, C; Nakazawa, T; Yamamoto, T | 1 |
| Frye, MA; Ketter, TA; Li, X | 1 |
| Klisch, J; Schumacher, M; Spreer, J; Thiel, T; Ziyeh, S | 1 |
| Angehagen, M; Ben-Menachem, E; Hansson, E; Rönnbäck, L | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M | 1 |
| Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ | 2 |
| Delgado-Charro, MB; Guy, RH | 1 |
| Cunningham, MO; Jones, RS; Woodhall, GL | 1 |
| Gao, Y; Lei, LS; Wu, SG | 1 |
| Ayala Guerrero, F; Barragán Mejía, G; Calderón Guzmán, D; Espitia Vázquez, I; Juárez Olguín, H; Labra Ruiz, N; Rodríguez Pérez, R; Santamaria del Angel, D | 1 |
| Dager, SR; Demopulos, C; Dunner, DL; Friedman, SD; Hirashima, F; Lyoo, IK; Parow, A; Renshaw, PF; Stoll, AL | 1 |
| Boldingh, KA; Hassel, B; Iversen, EG; Morland, C | 1 |
| Armijo, JA; Cuadrado, A | 1 |
| Shao, L; Wang, JF; Young, LT | 1 |
| Gobbi, G; Janiri, L | 1 |
| Abekawa, T; Ito, K; Koyama, T | 1 |
| Kapaki, E; Limpitaki, G; Paraskevas, GP; Petropoulou, O; Triantafyllou, NI; Vassilopoulos, D | 1 |
| Chang, K; Howe, M; Saxena, K; Simeonova, D; Steiner, H | 1 |
| Puente, V; Rodriguez-Campello, A; Roquer, J; Segura-Bruna, N | 1 |
| Chuang, DM; Leng, Y | 1 |
| Jaseja, H | 1 |
| Brown, JF; Cezar, GG; Gage, FH; Muotri, AR; Piekarczyk, MS; Quam, JA; Rosa, GJ; Smith, AM | 1 |
| Sümegi, A | 1 |
| Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S | 1 |
| Chuang, DM; Leng, Y; Marinova, Z; Nau, H; Reis-Fernandes, MA | 1 |
| Xie, W; Yu, Y; Zhao, Y | 1 |
| Kaneko, S; Motomura, E; Nakagawa, M; Ohoyama, K; Okada, M; Yamamura, S; Yoshida, S | 1 |
| Desai, PV; Therisa, KK | 1 |
| Baverel, G; El Hage, M; Martin, G | 1 |
| Adler, CM; Alfieri, DC; Blom, TJ; Bryan, HS; Chu, WJ; DelBello, MP; Kim, MJ; Lee, JH; Nandagopal, JJ; Patel, NC; Strakowski, SM; Strawn, JR; Welge, JA | 1 |
| Bambini-Junior, V; Batassini, C; Bristot Silvestrin, R; Brolese, G; Daniele Bobermim, L; Galland, F; Gonçalves, CA; Gottfried, C; Quincozes-Santos, A; Riesgo, R; Torres Abib, R; Zanotto, C | 1 |
| Eisenach, JC; Hayashida, K; Yoshizumi, M | 1 |
| Choi, CS; Go, HS; Jeon, SJ; Kim, JW; Kim, KC; Kim, P; Lee, DK; Shin, CY; Song, MR | 1 |
| Chuang, DM; Fessler, EB; Leeds, P; Leng, Y; Tsai, LK; Wang, J; Wang, Z | 1 |
| Correa-Basurto, J; Fonseca-Sabater, Y; Fragoso-Vazquez, MJ; Luna-Palencia, GR; Martinez-Ramos, F; Mendez-Luna, D; Mendieta-Wejebe, JE; Meraz-Rios, MA; Padilla-Martínez, II; Sixto-Lopez, Y; Trujillo-Ferrara, J; Vasquez-Moctezuma, I | 1 |
| Angelucci, F; Bernardini, S; Caltagirone, C; Croce, N; Gelfo, F; Mathé, AA | 1 |
| Angelucci, F; Bernardini, S; Caltagirone, C; Croce, N | 1 |
| Dowben, JS; Keltner, NL; Kowalski, PC | 1 |
| Aitta-aho, T; Korpi, ER; Maksimovic, M | 1 |
| Liu, Z; Peng, L; Song, D; Verkhratsky, A; Yan, E | 1 |
| Díaz, FV; Rasgado, LA; Reyes, GC | 1 |
| Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A | 1 |
| Goel, RK; Singh, T | 1 |
| Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K | 1 |
| Fukuyama, K; Murata, M; Okada, M; Okubo, R; Shiroyama, T | 1 |
| Augustyniak, J; Lazarewicz, JW; Lenart, J; Zieminska, E | 1 |
| Ang, MJ; Cho, GW; Jang, CH; Kim, J; Moon, C; Park, I; Song, A; Vijayakumar, KA | 1 |
| Arlicot, N; Barantin, L; Belzung, C; Bonnet-Brilhault, F; Briend, F; Chalon, S; Dupont, AC; Emond, P; Galineau, L; Gissot, V; Gomot, M; Houy-Durand, E; Laumonnier, F; Lefevre, A; Mavel, S; Nadal, L; Roussel, C; Roux, S; Santiago-Ribeiro, MJ; Tauber, C; Vercouillie, J | 1 |
| Abdelhakam, DA; Aboul-Ela, YM; Aboul-Fotouh, S; Ebeid, MA; Elnahas, EM; Habib, MZ; Negm, EA; Sadek, DR; Tarek, M | 1 |
5 review(s) available for valproic acid and glutamic acid
| Article | Year |
|---|---|
Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Lithium; Signal Transduction; Synaptic Transmission; Valproic Acid | 2002 |
Valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Brain; Brain Edema; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carnitine; Diagnosis, Differential; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Valproic Acid | 2006 |
Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosis.
Topics: Calcium Channels; Cerebral Palsy; Electroencephalography; Epilepsy; Glutamic Acid; Humans; Intracellular Space; Neurons; Neurotoxins; Prognosis; Valproic Acid | 2007 |
Identification of small molecules from human embryonic stem cells using metabolomics.
Topics: Biomarkers; Cell Culture Techniques; Cell Differentiation; DNA Primers; Embryonic Stem Cells; Folic Acid; Glutamic Acid; Humans; Kynurenine; Metabolism; Pyrrolidonecarboxylic Acid; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2007 |
[Mood stabilizers--past, present and future].
Topics: Affect; Antimanic Agents; Bipolar Disorder; Calcium; Carbamazepine; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Lithium Compounds; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mood Disorders; Triazines; Valproic Acid | 2008 |
5 trial(s) available for valproic acid and glutamic acid
| Article | Year |
|---|---|
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.
Topics: Adult; Ammonia; Anticonvulsants; Astrocytes; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Occipital Lobe; Refractory Period, Electrophysiological; Valproic Acid | 1999 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid | 2003 |
Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder.
Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Brain Mapping; Case-Control Studies; Echo-Planar Imaging; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Lactic Acid; Lithium; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Valproic Acid | 2004 |
Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: relation to treatment response.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Glutamic Acid; Humans; Lamotrigine; Male; Time Factors; Triazines; Valproic Acid | 2006 |
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Cyclothymic Disorder; Depressive Disorder, Major; Dysthymic Disorder; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Risk Factors; Valproic Acid | 2006 |
71 other study(ies) available for valproic acid and glutamic acid
| Article | Year |
|---|---|
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.
Topics: Amino Acid Sequence; Animals; Benzoic Acid; Biological Transport; Carboxylic Acids; Carrier Proteins; Cell Line; Digestive System; Hydrogen-Ion Concentration; Immunohistochemistry; Intestinal Absorption; Lactic Acid; Molecular Sequence Data; Monocarboxylic Acid Transporters; Rats; Tissue Distribution; Transfection | 1999 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Cytochrome aa3 depletion is the cause of the deficient mitochondrial respiration induced by chronic valproate administration.
Topics: Animals; Citrate (si)-Synthase; Cytochrome-c Oxidase Deficiency; Electron Transport Complex IV; Glutamates; Glutamic Acid; Male; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Inbred Strains; Succinate Dehydrogenase; Succinates; Succinic Acid; Valproic Acid | 1992 |
Receptor-coupled uptake of valproate in rat astroglial primary cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Clonidine; Drug Interactions; Glutamates; Glutamic Acid; Isoproterenol; Kainic Acid; Ketanserin; Phenylephrine; Prazosin; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin; Valproic Acid; Yohimbine | 1992 |
Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Rats, Inbred Strains; Valproic Acid | 1992 |
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid | 1989 |
Central GABA-ergic mechanism in stress-induced gastric ulceration.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Neurotransmitter Agents; Picrotoxin; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Valproic Acid | 1985 |
[Mechanism of the tranquilizing action of electron structural analogs of nicotinamide].
Topics: Animals; Benzodiazepinones; Bicuculline; Brain; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inosine; Male; Niacinamide; Radioligand Assay; Rats; Receptors, GABA-A; Serotonin; Synaptosomes; Tranquilizing Agents; Valproic Acid | 1986 |
Effects of organic acids on the synthesis of citrulline by intact rat liver mitochondria.
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Adenosine Triphosphate; Animals; Butyrates; Citrulline; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Glutamates; Glutamic Acid; Kinetics; Male; Mitochondria, Liver; Propionates; Rats; Rats, Inbred Strains; Succinates; Succinic Acid; Valproic Acid | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
The presynaptic effects of valproic acid in the isolated frog spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Electric Conductivity; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Potassium; Rana pipiens; Spinal Cord; Synapses; Valproic Acid | 1981 |
A new patient with 4-hydroxybutyric aciduria, a possible defect of 4-aminobutyrate metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Male; Sodium Oxybate; Valproic Acid | 1983 |
Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid.
Topics: Amino Acids; Aminooxyacetic Acid; Animals; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrazines; Isoniazid; Male; Mice; Pyridoxal Phosphate; Pyridoxine; Synaptosomes; Valproic Acid | 1984 |
Determination of gamma-aminobutyric and glutamic acids in rat brain by liquid chromatography with electrochemical detection.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Electrochemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Rats; Substantia Nigra; Valproic Acid | 1984 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid | 1994 |
Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Phenytoin; Rats; Seizures; Valproic Acid | 1995 |
Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.
Topics: Animals; Brain; Corpus Striatum; Dose-Response Relationship, Drug; Fatty Acids; Frontal Lobe; Glutamic Acid; Hippocampus; Male; Permeability; Rats; Rats, Sprague-Dawley; Valproic Acid | 1996 |
A novel action of lithium: stimulation of glutamate release and inositol 1,4,5 trisphosphate accumulation via activation of the N-methyl D-aspartate receptor in monkey and mouse cerebral cortex slices.
Topics: Animals; Calcium Channels; Cerebral Cortex; Cyclopentanes; Excitatory Amino Acid Antagonists; Glutamic Acid; Haplorhini; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Lithium; Mice; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1996 |
Inhibition of carnitine biosynthesis by valproic acid in rats--the biochemical mechanism of inhibition.
Topics: Acetyl Coenzyme A; Animals; Anticonvulsants; Betaine; Carnitine; Coenzyme A; Glutamic Acid; Humans; Ketoglutaric Acids; Liver; Male; Rats; Rats, Wistar; Valproic Acid | 1996 |
The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cerebral Cortex; Drug Interactions; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Male; Mice; Mice, Inbred ICR; Molecular Mimicry; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1997 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; Disease Susceptibility; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Homovanillic Acid; Hydroxyindoleacetic Acid; Mesencephalon; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Species Specificity; Tyrosine 3-Monooxygenase; Valproic Acid | 1996 |
Inhibitory effect of valproate on weak organic acid uptake in rat renal proximal tubules.
Topics: Ammonia; Animals; Anticonvulsants; Fluorescein; Glutamic Acid; Glutamine; Kidney Tubules, Proximal; Male; Rats; Rats, Wistar; Valproic Acid | 1999 |
Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria.
Topics: Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Fluorescein; Glutamic Acid; Ketoglutaric Acids; Kidney Cortex; Mitochondria; Rats; Succinates; Tricarboxylic Acids; Valproic Acid | 2000 |
Enzyme inhibition XI: glutamate decarboxylase activity relationship with the reaction products as determined by the colorimetric and radioisotopic methods.
Topics: Arsenates; Carbon Radioisotopes; Colorimetry; Enzyme Inhibitors; Escherichia coli; Glutamate Decarboxylase; Glutamic Acid; Substrate Specificity; Valproic Acid | 1999 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid | 2000 |
Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate.
Topics: Amino Acid Transport System X-AG; Amino Acids; Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Biological Transport, Active; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutaminase; Hippocampus; Immunoblotting; Male; Rats; Rats, Wistar; Receptors, Neurotransmitter; Synapsins; Up-Regulation; Valproic Acid | 2001 |
The acute effect of valproate on cerebral energy metabolism in mice.
Topics: Acetates; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Brain; Citric Acid Cycle; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Phosphocreatine; Valproic Acid | 2001 |
Tricarboxylic acid cycle of glia in the in vivo human brain.
Topics: Acetates; Adult; Bicarbonates; Brain; Carbon Isotopes; Citric Acid Cycle; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroglia; Oxidation-Reduction; Valproic Acid | 2002 |
Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.
Topics: Animals; Antimanic Agents; Calcium; Cells, Cultured; Cerebral Cortex; Cytoprotection; Dose-Response Relationship, Drug; Glutamic Acid; Ion Transport; Lithium; Neurons; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors; Tyrosine; Valproic Acid | 2002 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid | 2002 |
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Fructose; Glutamic Acid; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Topiramate; Valproic Acid | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
Effects of chronic lithium and sodium valproate on concentrations of brain amino acids.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Lithium; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Taurine; Valproic Acid | 2003 |
Transdermal reverse iontophoresis of valproate: a noninvasive method for therapeutic drug monitoring.
Topics: Administration, Cutaneous; Animals; Calibration; Drug Monitoring; Feasibility Studies; Glutamic Acid; In Vitro Techniques; Iontophoresis; Skin; Skin Absorption; Swine; Time Factors; Valproic Acid | 2003 |
Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Valproic Acid; Zolpidem | 2003 |
[Effects of chronic valproic acid sodium treatment and withdrawal on glutamate and glutamine release of C6 glioma cells].
Topics: Anticonvulsants; Glioma; Glutamic Acid; Glutamine; Humans; Time Factors; Tumor Cells, Cultured; Valproic Acid | 2003 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2003 |
Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbon Radioisotopes; Cell Death; Deoxyglucose; Dopamine; Glutamic Acid; Histones; HSP70 Heat-Shock Proteins; Male; Malonates; Mitogen-Activated Protein Kinases; Neostriatum; Neurons; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Valproic Acid; Weight Gain | 2004 |
Beneficial interaction between vigabatrin and valproate against seizures induced by pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Pentylenetetrazole; Valproic Acid; Vigabatrin | 2005 |
Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells.
Topics: Animals; Antimanic Agents; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; In Situ Nick-End Labeling; Lipid Peroxidation; Lithium; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Valproic Acid | 2005 |
Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex.
Topics: Action Potentials; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Prefrontal Cortex; Quisqualic Acid; Rats; Rats, Wistar; Salts; Sodium; Synapses; Valproic Acid | 2006 |
Valproate blocks high-dose methamphetamine-induced behavioral cross-sensitization to locomotion-inducing effect of dizocilpine (MK-801), but not methamphetamine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Locomotion; Male; Methamphetamine; Microdialysis; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Valproic Acid | 2006 |
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.
Topics: Acetylation; alpha-Synuclein; Animals; Anticonvulsants; Antimanic Agents; Cells, Cultured; Cerebellum; Cerebral Cortex; Glutamic Acid; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Neuroprotective Agents; Oligonucleotides, Antisense; Phenylbutyrates; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ubiquitin-Conjugating Enzymes; Valproic Acid | 2006 |
The effect of sodium valproate on proton MRS visible neurochemical concentrations.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Valproic Acid | 2007 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult | 2009 |
Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.
Topics: Acetylation; Animals; Cell Survival; Cells, Cultured; Cerebellum; Fatty Acids, Unsaturated; Glutamic Acid; Histone Deacetylase Inhibitors; HSP72 Heat-Shock Proteins; Neuroprotective Agents; Rats; RNA, Messenger; Structure-Activity Relationship; Valproic Acid | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Glutamic Acid; Hippocampus; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Random Allocation; Rats; Valproic Acid | 2010 |
Effects of valproate on neurotransmission associated with ryanodine receptors.
Topics: Animals; Antimanic Agents; Blotting, Western; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Valproic Acid | 2010 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Neurons; Pentylenetetrazole; Valproic Acid | 2011 |
Effects of valproate on glutamate metabolism in rat brain slices: a (13)C NMR study.
Topics: Animals; Brain; Carbon Isotopes; Energy Metabolism; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Organ Culture Techniques; Rats; Rats, Wistar; Valproic Acid | 2012 |
Glutamatergic effects of divalproex in adolescents with mania: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Cerebral Cortex; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Neurotransmitter Agents; Psychiatric Status Rating Scales; Remission Induction; Treatment Outcome; Valproic Acid | 2012 |
Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Autistic Disorder; Disease Models, Animal; Female; Glutamic Acid; Hippocampus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Valproic Acid | 2013 |
Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hyperalgesia; Male; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Spinal Cord; Valproic Acid | 2013 |
Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring.
Topics: Animals; Autistic Disorder; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Eye Proteins; Female; Glutamic Acid; Homeodomain Proteins; Neurogenesis; Neurons; Paired Box Transcription Factors; PAX6 Transcription Factor; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Repressor Proteins; Up-Regulation; Valproic Acid | 2014 |
FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers.
Topics: Animals; Animals, Newborn; Antimanic Agents; Cells, Cultured; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; Fibroblast Growth Factors; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Hippocampus; Lithium; Male; Mice; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Rats; Rats, Sprague-Dawley; Transduction, Genetic; Valproic Acid | 2015 |
Three amino acid derivatives of valproic acid: design, synthesis, theoretical and experimental evaluation as anticancer agents.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Glutamic Acid; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Dynamics Simulation; Proline; Repressor Proteins; Structure-Activity Relationship; Valproic Acid | 2014 |
Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration.
Topics: Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Survival; Drug Synergism; Gene Expression Regulation; Glutamic Acid; Humans; Lithium Carbonate; Neurons; Neuroprotective Agents; Valproic Acid | 2014 |
Lithium/Valproic acid combination and L-glutamate induce similar pattern of changes in the expression of miR-30a-5p in SH-SY5Y neuroblastoma cells.
Topics: Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation; Glutamic Acid; Humans; In Vitro Techniques; Lithium; MicroRNAs; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Real-Time Polymerase Chain Reaction; Up-Regulation; Valproic Acid | 2014 |
Ammonium: the deadly toxin you don't want to miss when using mood stabilizers.
Topics: Adult; Aged, 80 and over; Ammonium Compounds; Female; Glutamic Acid; Humans; Hyperammonemia; Male; Mood Disorders; Neurotoxicity Syndromes; Valproic Acid; Young Adult | 2013 |
Reversal of novelty-induced hippocampal c-Fos expression in GluA1 subunit-deficient mice by chronic treatment targeting glutamatergic transmission.
Topics: Animals; CA3 Region, Hippocampal; Exploratory Behavior; Female; Fructose; Glutamic Acid; Hippocampus; Lamotrigine; Lithium Compounds; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuroprotective Agents; Nitriles; Proto-Oncogene Proteins c-fos; Pyridones; Receptors, AMPA; Synaptic Transmission; Topiramate; Triazines; Valproic Acid | 2014 |
Chronic treatment with anti-bipolar drugs suppresses glutamate release from astroglial cultures.
Topics: Adenosine Triphosphate; Animals; Antimanic Agents; Astrocytes; Biological Transport; Calcium; Carbamazepine; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Lithium Carbonate; Mice; Potassium Chloride; Primary Cell Culture; Valproic Acid | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Male; Mice; Oxidation-Reduction; Oxygen Consumption; Pentylenetetrazole; Phenytoin; Seizures; Time Factors; Valproic Acid | 2015 |
Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study.
Topics: Animals; Animals, Newborn; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Motor Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Spinal Cord; Valproic Acid | 2015 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; Epilepsy; Glutamic Acid; Hindlimb Suspension; Kindling, Neurologic; Male; Mice; Neurochemistry; Norepinephrine; Pentylenetetrazole; Seizures; Serotonin; Treatment Outcome; Valproic Acid | 2016 |
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epilepsy; Glioblastoma; Glutamic Acid; Humans; Nitriles; Pyridones; Receptors, AMPA; Seizures; Up-Regulation; Valproic Acid | 2019 |
Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine.
Topics: Antipsychotic Agents; Astrocytes; Cell Membrane; Clozapine; Connexin 43; Glutamic Acid; Humans; Myocarditis; Schizophrenia; Serine; Valproic Acid | 2020 |
Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test.
Topics: Animals; Autistic Disorder; Cerebellum; Cerebral Cortex; Female; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamic Acid; Hippocampus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Valproic Acid; Vesicular Glutamate Transport Protein 1 | 2020 |
Neuroprotective Effect of Valproic Acid on Salicylate-Induced Tinnitus.
Topics: Animals; Cell Line, Tumor; Glutamic Acid; Humans; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Salicylates; Tinnitus; Valproic Acid | 2021 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Glutamic Acid; Humans; Male; Pregnancy; Rats; Synapses; Valproic Acid | 2023 |
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing.
Topics: Adenosine Deaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Glutamic Acid; Pregnancy; Rats; Receptors, AMPA; Risperidone; RNA; RNA Editing; Valproic Acid | 2023 |