valproic acid has been researched along with gamma-aminobutyric acid in 560 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 260 (46.43) | 18.7374 |
| 1990's | 112 (20.00) | 18.2507 |
| 2000's | 108 (19.29) | 29.6817 |
| 2010's | 62 (11.07) | 24.3611 |
| 2020's | 18 (3.21) | 2.80 |
| Authors | Studies |
|---|---|
| Brahce, L; Gregor, VE; Lobbestael, SJ; Mayhugh, DR; Nugiel, D; Pavia, MR; Schwarz, RD; Taylor, CP; Vartanian, MG | 1 |
| Mori, Y; Nakamura, J; Sasaki, H; Shibasaki, J | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Bora-Tatar, G; Dalkara, S; Dayangaç-Erden, D; Demir, AS; Erdem-Yurter, H; Yelekçi, K | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Chien, C; Jung, K; Ross-Townsend, A | 1 |
| Koella, WP; Olpe, HR; Schmutz, M | 1 |
| Blanc-Bimar, MC; Bouyard, P; Bruguerolle, B; Jadot, G; Valli, M | 1 |
| Koran, LM | 1 |
| van den Berg, CJ | 1 |
| Bruni, J; Wilder, BJ | 1 |
| Agnoli, A; Ciancarelli, G; Forchetti, C; Pacitti, C; Scarnati, E | 1 |
| Turner, AJ; Whittle, SR | 1 |
| Qu, ZP | 1 |
| Chase, TN; Kartzinel, R; Shoulson, I | 1 |
| Ferguson, IT; Fleming, AM; Herzberg, M; Lenman, JA; Robb, JE; Turnbull, MJ | 1 |
| Anlezark, GM; Horton, RW; Meldrum, BS; Sawaya, MC | 1 |
| Ciesielski, L; Gensburger, C; Mandel, P; Simler, S | 3 |
| Perry, TL | 1 |
| Hansen, S; Perry, TL | 1 |
| Avanzini, G; Caraceni, T; Giovannini, P; Girotti, F | 1 |
| Bennett, JP; Coyle, JT; Schwarcz, R | 1 |
| Bruinvels, J; de Boer, T; Metselaar, HJ | 1 |
| Maxion, H; Schneider, E; Ziegler, B | 1 |
| Feussner, GK; Lust, WD; McCandless, DW; Passonneau, JV | 1 |
| Hayashi, T; Negishi, K | 1 |
| Frey, HH; Löscher, W | 2 |
| Cocchi, R; Tornati, A | 1 |
| Deguchi, T; Kukino, K | 2 |
| Stone, WE | 1 |
| Bonfiglio, G; Falli, S; Pacini, A | 1 |
| DeFeudis, FV; García-Gracia, M; Martin del Rio, R; Orensanz Muñoz, LM | 1 |
| Costall, B; Naylor, RJ; Owen, RT | 1 |
| Sethy, VH | 1 |
| Grove, J; Schechter, PJ; Tranier, Y | 1 |
| Grecksch, G; Matthies, H; Wetzel, W | 1 |
| Löscher, W | 9 |
| Bruinvels, J; de Boer, T; van der Laan, JW | 1 |
| Butler, IJ; Enna, SJ; Ferkany, JW | 1 |
| Bulaev, VM; Ostrovskaia, RU | 1 |
| Bergey, GK; Macdonald, RL | 2 |
| Arnauld, E; Blume, HW; Lamour, Y; Layton, BS; Renaud, LP | 1 |
| Metcalf, BW | 1 |
| Calne, DB; Eng, N; Nutt, J; Plotkin, C; Williams, A; Ziegler, M | 1 |
| Taberner, PV | 1 |
| Gale, K; Iadarola, MJ | 3 |
| Banay-Schwartz, M; De Guzman, T; Lajtha, A; Zanchin, G | 1 |
| Ciesielski, L; Kempf, E; Mack, G; Maitre, M; Mandel, P; Simler, S | 1 |
| Sarhan, S; Seiler, N | 1 |
| Avery, GS; Brogden, RN; Pinder, RM; Speight, TM | 1 |
| Defeudis, FV; Gonzalez-Portal, C; Kulig, BM; Somoza, E | 1 |
| Crosset, P; Klawans, HL; Patel, BC | 1 |
| Anlezark, GM; Horton, RW; Meldrum, BS; Sawaya, MC; Stephenson, JD | 1 |
| Anlezark, G; Horton, RW; Meldrium, BS; Sawaya, CB | 1 |
| Gillies, R; Mandel, P; Noble, EP; Vigran, R | 1 |
| Emson, PC | 1 |
| Markovich, VV; Molodavkin, GM; Ostrovskaia, RU | 1 |
| Elazar, Z; Gottesfeld, Z | 1 |
| Cash, C; Ciesielski, L; Maitre, M; Mandel, P | 1 |
| Caffarri, G; Capretti, L; Cavazzini, U; Chiodera, P; Coiro, V; Davoli, C; Marcato, A; Rossi, G; Volpi, R | 1 |
| Biggio, G; Concas, A; Mascia, MP; Pepitoni, S; Sanna, E; Serra, M | 1 |
| Hansson, E; Nilsson, M; Rönnbäck, L | 2 |
| Biggs, CS; Fowler, LJ; Pearce, BR; Whitton, PS | 2 |
| Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W | 1 |
| Mattes, JA | 1 |
| Fontaine, R; Ontiveros, A | 1 |
| Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H | 1 |
| Bianconi, L; Capretti, L; Castelli, A; Cerri, L; Chiodera, P; Coiro, V; Marcato, A; Roberti, G; Volpi, R | 1 |
| Corbett, R; Cornfeldt, M; Dunn, RW; Fielding, S | 1 |
| Hayashi, J; Kawasaki, S; Nakagawa, M; Nakata, T; Oguro, M; Sasaki, S; Takeda, K | 1 |
| Abed, WT | 1 |
| Cabezas Agricola, J; Cabezas-Cerrato, J; Lado Abeal, J; Paz Carreira, JM | 1 |
| Fredow, G; Löscher, W | 1 |
| Löscher, W; Wahnschaffe, U | 1 |
| Higuchi, T; Kato, N; Minatogawa, Y; Nagaki, S | 1 |
| Anton, RF; Becker, HC | 1 |
| Cotariu, D; Evans, S; Zaidman, JL | 1 |
| Bhowmick, S; Bose, R; Pal, M; Pal, SP | 1 |
| Bieniarz, K; Breton, B; Epler, P; Mikolajczyk, T; Ollevier, F; Roelants, I | 1 |
| Hoeppner, TJ | 1 |
| Macdonald, RL; McLean, MJ; Skerritt, JH | 1 |
| Nishikawa, T; Scatton, B; Serrano, A | 1 |
| Agopyan, N; Avoli, M; Rieb, L; Tancredi, V | 1 |
| Chung, EY; Rosenbaum, D; Van Woert, MH | 1 |
| Chung, EY; Van Woert, MH | 1 |
| Abdikaliev, NA; Meerson, FZ; Shabunina, EV | 1 |
| Aley, KO; Kulkarni, SK | 1 |
| Farrant, M; Webster, RA | 1 |
| Chiodera, P; Coiro, V | 1 |
| Amenta, F; Erdö, SL; Ezer, E; Matuz, J; Wolff, JR | 1 |
| Drac-Kaniewska, J; Jeske, W; Kasperlik-Załuska, A; Migdalska, B; Wiśniewska-Woźniak, T | 1 |
| Morselli, PL | 1 |
| Aranko, K; File, SE | 1 |
| Bianconi, L; Castelli, A; Chiodera, P; d'Amato, L; Gnudi, A; Marchesi, C; Minelli, R; Muzzetto, P; Pioli, G; Volpi, R | 1 |
| Brugger, F; Olpe, HR; Pozza, MF; Schmutz, M; Steinmann, MW | 1 |
| Bhargava, KP; Gupta, GP; Gupta, MB | 1 |
| Keane, PE; Morre, M; Simiand, J | 1 |
| Aleksandrovskiĭ, IuA; Kharlamov, AN; Neznamov, GG; Poiurovskiĭ, MV; Raevskiĭ, KS | 1 |
| Clayton, RM; Sedowofia, SK | 1 |
| Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS | 2 |
| Meldrum, BS | 1 |
| Akhundov, RA; Rozhanets, VV; Val'dman, AV; Voronina, TA | 1 |
| Macdonald, RL; McLean, MJ | 2 |
| Higuchi, T; Igarashi, Y; Kato, N; Minatogawa, Y; Nagaki, S; Ohshima, H; Takazawa, A; Watanabe, N; Yamazaki, J; Yamazaki, O | 1 |
| Kent, AP; Webster, RA | 1 |
| Barnhill, JG; Greenblatt, DJ; Miller, LG; Shader, RI; Summer, WR | 1 |
| Fujita, S; Ichii, S; Kusunoki, M; Nakai, T; Utsunomiya, J; Yamamura, T | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Arcadi, F; Arcoraci, V; Caputi, AP; Squadrito, F; Sturniolo, R | 1 |
| Green, AR; Johnson, P; Mountford, JA; Nimgaonkar, VL | 1 |
| Moura, D; Soares-da-Silva, P | 1 |
| Buchhalter, JR; Dichter, MA | 1 |
| Monteleone, P; Steardo, L; Zontini, G | 1 |
| Dewhurst, DG | 1 |
| Lloyd, KG | 1 |
| Borsook, D; Brennan, MJ; Moore-Ede, MC; Richardson, GS | 1 |
| Ciesielski, L; Gobaille, S; Mandel, P; Molina, V | 1 |
| Gale, K | 1 |
| Antinori, D; de Ruggiero, A; Fioretti, P; Mais, V; Melis, GB; Paoletti, AM | 1 |
| Iovino, M; Monteleone, P; Orio, F; Steardo, L | 1 |
| Kurlemann, G; Palm, DG | 1 |
| Chapman, AG | 2 |
| Beneventi, F; Fioretti, P; Mais, V; Melis, GB; Paoletti, AM; Petacchi, FD | 1 |
| Iovino, M; Maj, M; Monteleone, P; Steardo, L | 1 |
| Duncan, CC; Mirsky, AF; Myslobodsky, MS | 1 |
| Forni, C; Halsey, MJ; Rostain, JC; Wardley-Smith, B | 1 |
| Agrusta, M; Iovino, M; Monteleone, P; Orio, F; Steardo, L | 2 |
| Lane, JD; Lasley, SM; Wimbish, GH | 1 |
| Chadwick, D; Crawford, P | 1 |
| Ascher, MS; Elias, AN; Iyer, K; Kyaw, T; Stone, S; Weathersbee, P | 1 |
| Kaufman, EE; Nelson, T | 1 |
| Cupello, A; Hydén, H; Palm, A | 2 |
| Kolokouris, N; Vamvakidès, A | 1 |
| Rietveld, WJ; van Schravendijk, K | 1 |
| Belkina, LM; Meerson, FZ; Pshennikova, MG; Shabunina, EV | 1 |
| Draye, JP; Vamecq, J | 1 |
| Chapman, AG; De Sarro, GB; Meldrum, BS; Premachandra, M | 1 |
| Lakke, JP; Snoek, JW; Teelken, AW; van den Burg, W; van Weerden, TW | 1 |
| Klee, MR; Preisendörfer, U; Zeise, ML | 1 |
| Cupo, A; Jarry, T; Vion-Dury, J | 1 |
| Kaufman, EE; Miller, D; Nelson, T; Stadlan, N | 1 |
| Goldstein, R; Rodica, B | 1 |
| Gibson, KM; Nyhan, WL; Pattarelli, PP | 1 |
| Martin, A; Martin, C; Rud, C; Valli, M | 1 |
| Gram, L | 1 |
| Comi, G; Ferini-Strambi, L; Filippi, M; Giusti, MC; Medaglini, S; Poggi, A; Smirne, S | 1 |
| Goto, S; Ichikawa, M; Matsuyama, K; Miyazaki, C | 1 |
| Bianchi, A; Brunet, C; Luyckx, M; Paluszezak, D | 1 |
| Emrich, HM; Tscherne, U; Wolf, R | 1 |
| Ferrara, LP; Slevin, JT | 1 |
| Löscher, W; Vetter, M | 3 |
| Burke, JT; Thénot, JP | 1 |
| Baleydier-Giroud, F; Desgres, J; Dumas, R; Giroud, M; Marchal, G | 1 |
| Keane, PE; Morre, M | 1 |
| Böhme, G; Löscher, W; Müller, F; Pagliusi, S | 1 |
| Böhme, G; Löscher, W; Stoltenburg-Didinger, G; Vetter, M | 1 |
| Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M | 1 |
| Fukuyama, Y; Izumi, T; Osawa, M; Utsumi, H | 1 |
| Garg, SK; Kulkarni, SK; Mathur, VS; Shukla, VK | 1 |
| Bencze, W; Bernasconi, R; Hauser, K; Klein, M; Martin, P; Schmutz, M | 1 |
| Dostert, P; Rumigny, JF; Strolin Benedetti, M | 1 |
| Dunn, R; Fielding, S; Kruse, H; Lal, H; Shearman, GT; Theurer, K | 1 |
| Lascelles, PT; Patsalos, PN | 1 |
| Casu, M; Gale, K | 1 |
| Kharlamov, AN; Kozlovskaia, MM; Raevskiĭ, KS; Val'dman, AV | 1 |
| Abraham, RR; Beckford, U; Dornhorst, A; Gillham, B; Jones, MT; Seed, M; Wynn, V | 1 |
| Davidoff, RA; Grayson, V; Hackman, JC | 1 |
| Rump, S | 1 |
| Polc, P | 1 |
| Baltassat, P; Cotte, J; Divry, P; Duran, M; Hermier, M; Rolland, MO; Wadman, SK | 1 |
| Chapman, A; Keane, PE; Meldrum, BS; Simiand, J; Vernieres, JC | 1 |
| Garbutt, JC; van Kammen, DP | 1 |
| Geddes, JW; Wood, JD | 1 |
| Bulayev, VM; Ostrovskaya, RU; Zakusov, VV | 1 |
| Fünfgeld, EW; Henkel, H; Kausen, J; Klenke, D; Zimmermann, P | 1 |
| Löscher, W; Siemes, H | 1 |
| Altaher, AR; Campbell, EA; Gillham, B; Jones, MT; Nicholson, SA; Thody, A; Watts, SM | 1 |
| Greenland, RD; Lasley, SM; Michaelson, IA | 1 |
| Vellucci, SV; Webster, RA | 1 |
| Morag, M; Myslobodsky, MS | 2 |
| Meldrum, B | 1 |
| Bouyard, P; Bruguerolle, B; Jadot, G; Valli, M | 1 |
| Brancasi, B; Genco, S; Minervini, MG; Napoletano, V; Puca, FM; Reggio, F; Specchio, LM | 1 |
| Gallagher, JP; Inokuchi, H; Nakamura, J; Shinnick-Gallagher, P | 1 |
| Bruni, J; Hammond, EJ; Wilder, BJ | 1 |
| Morag, M; Myslobodsky, M | 1 |
| Bichard, AR; Little, HJ | 1 |
| Gardner, CR; Piper, DC | 1 |
| Harrison, NL; Simmonds, MA | 1 |
| Bons, EG; Lamberts, SW; Oosterom, R; Uitterlinden, P; Verleun, T | 1 |
| Adamec, R; Racine, RJ; Tuff, LP | 1 |
| Johnston, D | 1 |
| Löscher, W; Nau, H | 3 |
| Keane, PE; Morre, M; Roncucci, R; Simiand, J; Vernières, JC | 1 |
| Focà, A; Mastroeni, P; Nisticò, G; Rotiroti, D | 1 |
| Kharlamov, AN; Rayevsky, KS | 1 |
| Chapman, AG; Meldrum, BS; Mendes, E | 1 |
| Kofman, O; Myslobodsky, MS | 1 |
| Mandel, P; Puglisi-Allegra, S; Simler, S | 1 |
| Bero, C; Dircks, D; Fung, YK; Patch, RJ; Tomita, K; Witiak, DT | 1 |
| Chapman, AG; Meldrum, BS | 1 |
| Contreras, E; Tamayo, L | 1 |
| Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
| Fredholm, BB; Hare, TA; Murros, K; Ohisalo, JJ | 1 |
| Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J | 1 |
| de Varebeke, PJ; Korf, J; Niebes, P; Pauwels, G; Roba, J | 1 |
| Altmann, H; Dose, M; Emrich, HM; von Zerssen, D | 1 |
| Boldrini, A; Fioretti, P; Fruzzetti, F; Kemeny, A; Mais, V; Melis, GB; Paoletti, AM; Strigini, F | 1 |
| Hare, TA; Tamminga, CA; Thaker, GK | 1 |
| van der Laan, JW | 1 |
| Beneventi, F; Fioretti, P; Fruzzetti, F; Mais, V; Melis, GB; Paoletti, AM; Trimarchi, G | 1 |
| Chapman, AG; Croucher, MJ; Meldrum, BS | 1 |
| Battistin, L; Berlese, G; Roman, G; Varotto, M | 1 |
| Ostrovskaia, RU; Popova, NK | 1 |
| Caputi, AP; Costa, G; Di Giorgio, RM; Magrì, V; Quattrone, G; Squadrito, F; Trimarchi, GR | 1 |
| Bialer, M; Johno, I; Levy, RH; Nickelson, SA | 1 |
| Aslam, M; Fernando, NP; Harrison, PG; Healy, MA | 1 |
| Depaulis, A; Vergnes, M | 1 |
| Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G | 1 |
| Dhanaraj, M; Panneer, A; Srinivas, K | 1 |
| Ciesielski, L; Gobaille, S; Klein, M; Mandel, P; Simler, S | 1 |
| Bereksi, B; Boggio, V; Guilland, JC; Klepping, J; Mack, G; Noirot, P | 1 |
| Marsden, CD; Sheehy, MP | 1 |
| Haug, M; Kim, L; Mandel, P; Simler, S | 1 |
| Dahlström, S; Koulu, M; Lammintausta, R | 1 |
| Garvin, C | 1 |
| Gent, JP; Phillips, NI | 1 |
| Garibova, TL; Voronina, TA | 1 |
| Bartholini, G; Scatton, B | 1 |
| Angrist, B; Gershon, S; Heckl, K; Karobath, M; Lautin, A; Stanley, M | 1 |
| Löscher, W; Schmidt, D | 2 |
| Mandel, P; Puglisi-Allegra, S | 1 |
| Emrich, HM; Kissling, W; Möller, HJ; von Zerssen, D; Windorfer, A | 1 |
| Bartels, K; Bruinvels, J; de Boer, T; Metselaar, HJ | 1 |
| Emrich, HM; Kissling, W; Möller, HJ; von Zerssen, D | 1 |
| Kerwin, RW; Olpe, HR; Schmutz, M | 1 |
| Kerwin, RW; Taberner, PV | 1 |
| Epstein, M; Gonzalez-Pardo, L | 1 |
| Craig, CR; Ross, SM | 1 |
| Bruinvels, J; Jacobs, AW; van der Laan, JW | 1 |
| Baldino, F; Geller, HM | 2 |
| Kempf, E; Mandel, P; Puglisi-Allegra, S; Simler, S | 1 |
| Ostrovskaia, RU; Zakusov, VV | 1 |
| Bruinvels, J; Van der Laan, JW | 1 |
| Elias, AN; Grossman, M; Szekeres, AV; Valenta, LJ | 1 |
| Petersen, EN; Rasmussen, KJ; Schneider, HH | 1 |
| Schreiber, RA | 1 |
| Böhme, G; Kochen, W; Löscher, W; Schäfer, H | 1 |
| Fioretti, P; Fruzzetti, F; Gambacciani, M; Guarnieri, G; Mais, V; Mastrapasqua, NM; Melis, GB; Paoletti, AM; Strigini, F | 1 |
| Kurylo, E; Tsui, SK; Wood, JD | 1 |
| Ciesielski, L; Klein, M; Mandel, P; Simler, S | 1 |
| Elias, AN; Pahl, M; Stone, S; Valenta, LJ; Vaziri, ND | 1 |
| Elias, AN; Stone, S; Szekeres, AV; Valenta, LJ | 1 |
| Fowler, LJ; Phillips, NI | 1 |
| Caputi, AP; Losi, E; Nistico, G; Palella, B; Rotiroti, D | 1 |
| Depaulis, A; Rodgers, RJ | 1 |
| Bouyard, P; Bruguerolle, B; Ciesielski, L; Jadot, G; Mandel, P; Mesdjian, E; Valli, M | 1 |
| Ostrovskaia, RU; Ratnikov, VI; Riabinina, NE | 1 |
| Georgiev, V; Markovska, V | 1 |
| Hitchcock, E; Teixeira, M | 1 |
| Kelly, KM; Macdonald, RL | 3 |
| Avoli, M; Fueta, Y; Siniscalchi, A; Tancredi, V | 1 |
| Bialer, M; Hadad, S | 1 |
| Sayin, U; Timmerman, W; Westerink, BH | 1 |
| Becker, A; Grecksch, G; Ostner, C; Piönnigs, B | 1 |
| Abbott, FS; Burton, R; Palaty, J | 1 |
| Casto, DT; Haines, ST | 1 |
| Proeckl, D; Scollo-Lavizzari, G | 1 |
| Bolaños, JP; Medina, JM | 2 |
| Hekster, YA; Keyser, A; Lammers, MW; Meinardi, H; Renier, WO; van Lier, H; Wijsman, DJ | 1 |
| Caffarri, G; Caiazza, A; Capretti, L; Chiodera, P; Coiro, V; Colla, R; Maffei, ML; Volpi, R | 1 |
| Hörstermann, D; Löscher, W | 1 |
| Pierce, MW; Shu, VS | 1 |
| Guieu, R; Kopeyan, C; Rochat, H | 1 |
| Alfano, F; Caffarri, G; Caiazza, A; Capretti, L; Chiodera, P; Coiro, V; Maffei, ML; Pagani, D; Papadia, C; Volpi, R | 1 |
| Amico-Roxas, M; Caruso, A; Cutuli, VM; de Bernardis, E; Lucenti, A; Villari, L | 1 |
| Cabezas Agricola, JM; Cabezas-Cerrato, J; Lado Abeal, J; Rey Losada, C | 1 |
| Bocchi, R; Caffarri, G; Capretti, L; Chiodera, P; Coiro, V; Marcato, A; Rossi, G; Volpi, R | 1 |
| Hauhart, RE; Thurston, JH | 1 |
| Appleton, RE | 1 |
| Blake, ME; Bowden, CL; Calabrese, JR; Davis, JM; Kimmel, SE; Kramer, GL; Miller, MJ; Orsulak, PJ; Petty, F; Rush, AJ; Small, JG; Swann, AE | 1 |
| Mackenzie, RA | 1 |
| Fernández, MC; Petersen, LR; Walkotte, SM; Walter, FG | 1 |
| Buckland, PR; McGuffin, P; Spurlock, G | 1 |
| Davies, JA | 1 |
| Marsden, CA; Martin, KF; Rowley, HL | 1 |
| George, B; Kulkarni, SK | 1 |
| Nadi, NS; Pranzatelli, MR | 1 |
| Bourgeois, B | 1 |
| Cabezas-Cerrato, J; Febrero, M; Lado-Abeal, J; Liz, JL; Rey, C | 1 |
| Brady, LA; Do, SM; Fernandez, MC; Kloster, JC; Prosnitz, EH; Ruffenach, SJ; Salmon, JV; Villarin, A; Walter, FG | 1 |
| Capretti, L; Chiodera, P; Coiro, V; Volpi, R | 1 |
| Kubová, H; Mares, P; Polásek, R; Slamberová, R; Vorlícek, J | 1 |
| Herranz, JL | 1 |
| Agmo, A; Belzung, C; Giordano, M | 1 |
| Borriello, R; Cassandro, P; Maj, M; Monteleone, P; Natale, M; Tortorella, A | 1 |
| Brown-Croyts, LM; Ko, GY; Teyler, TJ | 1 |
| Bernasconi, R; Bittiger, H; De Barry, J; Marescaux, C; Mathivet, P | 1 |
| Alexiuk, NA; Vriend, JP | 1 |
| Hechler, V; Maitre, M; Ratomponirina, C | 1 |
| Chapman, DP; Giles, WH | 1 |
| Abbott, FS; Palaty, J; Tang, W | 1 |
| Caffarra, P; Chiodera, P; Coiro, V; Saccani, A; Scaglioni, A; Volpi, R | 1 |
| Caraballo, R; Cersósimo, R; Fejerman, N; Intruvini, S; Pociecha, J | 1 |
| Colao, A; Di Sarno, A; Di Somma, C; Ferone, D; Landi, ML; Lombardi, G; Merola, B; Sarnacchiaro, F; Tolino, A | 1 |
| Pellock, JM | 1 |
| Freeman, MP; Stoll, AL | 1 |
| Bazil, CW; Pedley, TA | 1 |
| Barros, HM; Tannhauser, M; Vargas, C | 1 |
| Chadwick, DW; Marson, AG | 1 |
| Boothe, DM | 1 |
| Morimoto, K; Sato, H; Suwaki, H; Watanabe, T; Yamamoto, Y | 1 |
| Bruni, J | 1 |
| Anderson, GD | 1 |
| Hartmann, C; Kellner, U; Pung, T; Ruether, K; Schmitz, B; Seeliger, M | 1 |
| Gómez-Marcos, A; González-Roncero, A; Romero-Rodríguez, JC; Vaquerizo, J | 1 |
| Evans, DL; Murphy, TK; Tueth, MJ | 1 |
| Klitgaard, H; Matagne, A | 1 |
| Brandl, U; Siemes, H; Spohr, HL; Völger, S; Weschke, B | 1 |
| Garaizar, C; Gil-Antón, J; Pérez-García, J; Prats, JM | 1 |
| Hagan, RM; Xie, X | 1 |
| Hagan, RM; Higgins, GA; Kirkby, D; Southam, E | 1 |
| Coiro, V; Vescovi, PP; Volpi, R | 1 |
| Arroyo, S; Martínez, I; Ribalta, T; Rumiá, J | 1 |
| Feely, M | 1 |
| Brodie, MJ; Mumford, JP | 1 |
| Arndt, CF; Defoort-Dhellemmes, S; Derambure, P; Hache, JC | 1 |
| Behar, KL; Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL | 1 |
| Brown, A; Dott, SG; Harris, A; Meyer, WJ; O'Boyle, M; Rose, RM; Wassef, AA | 1 |
| Chioni, A; Gatzonis, S; Laiaki, A; Mantouvalos, V; Siafakas, A; Zournas, C | 1 |
| Hamer, HM; Morris, HH | 1 |
| Lovell, RW | 1 |
| Gaily, E; Granström, ML; Liukkonen, E | 1 |
| Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ | 1 |
| Eckstein-Ludwig, U; Fei, J; Schwarz, W | 1 |
| Elger, CE; Fernández, G | 1 |
| Brodie, MJ | 1 |
| Radtke, RA; St Clair, EW; Verma, A | 1 |
| Bowden, CL; Calabrese, JR; Dilsaver, SC; Morris, DD; Petty, F; Swann, AC | 1 |
| Brückner, C; Heinemann, U | 1 |
| Carwile, ST; Husain, AM; Miller, PP; Radtke, RA | 1 |
| Chaudron, LH; Jefferson, JW | 1 |
| Allingham, B; Citrome, L; Levine, J | 1 |
| Badura, LL; Dodge, JC; Illig, AM; Snyder, PJ | 1 |
| Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y | 1 |
| Brodie, MJ; Butler, E; Duncan, R; Fraser, CM; Howatson, A; Lindsay, K; Sills, GJ; Thompson, GG | 1 |
| Baker, GB; Shiah, IS; Yatham, LN | 1 |
| Ueda, Y; Willmore, LJ | 1 |
| Ha, JH; Ha, JS; Huh, K; Kim, JA; Kim, JS; Lee, DU; Lee, JT; Yong, CS | 1 |
| Chronicle, EP; Mulleners, WM; Palmer, JE; Rolan, P | 1 |
| Bingmann, D; Bonnet, U; Hufnagel, A; Leniger, T; Wiemann, M | 1 |
| Harden, CL | 1 |
| Badura, LL; Illig, AM; Melia, K; Snyder, PJ | 1 |
| Benardo, LS; Yang, L | 1 |
| Jagoda, A; Yoon, Y | 1 |
| Nemeroff, CB | 1 |
| Coiro, V; Vescovi, PP | 1 |
| Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I | 1 |
| Jefferson, JW | 1 |
| Alao, AO; Dewan, MJ | 1 |
| Crockatt, JG; Janney, CA; Pande, AC; Tsaroucha, G; Werth, JL | 1 |
| Atzert, R; Brar, JS; Chengappa, KN; Delaney, J; Levin, H; Levine, J; Moffa, N; Parepally, H; Rathore, D; Solai, L | 1 |
| Sakai, K | 2 |
| Bowden, CL | 1 |
| Gundlapalli, SP; Iqbal, MM; Passman, TE; Ryals, T; Ryan, WG | 1 |
| Burdick, KE; Goldberg, JF | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Fonnum, F; Hassel, B; Johannessen, CU; Petersen, D | 1 |
| Chronicle, EP; Koehler, PJ; Mulleners, WM; Vredeveld, JW | 1 |
| Ketter, TA; Wang, PW | 1 |
| Chengappa, KN; Gershon, S; Levine, J | 1 |
| Covington, EC | 1 |
| Frye, MA; Ketter, TA; Li, X | 1 |
| Corbo, J | 1 |
| Rekling, JC | 1 |
| Grimee, R; Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J | 1 |
| Posner, E | 4 |
| Ernst, CL; Goldberg, JF | 1 |
| Shelton, RC | 1 |
| Keränen, T; Peltola, J; Rainesalo, S; Saransaari, P | 1 |
| Azaroual, N; Cartigny, B; Imbenotte, M; Lhermitte, M; Vermeersch, G | 1 |
| Freeman, MP; Gelenberg, AJ; Gnanadesikan, M | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Devanand, DP; Mehta, R; Sethi, MA | 1 |
| Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M | 1 |
| Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ | 1 |
| Cunningham, MO; Jones, RS; Woodhall, GL | 1 |
| Winterer, G | 1 |
| Basnet, A; Choi, J; Jahng, Y; Jeong, TC; Kim, DO; Kim, EK; Lee, ES; Moon, YS; Park, JG; Zhao, LX | 1 |
| Filatova, EG; Klimov, MV | 1 |
| Ayala Guerrero, F; Barragán Mejía, G; Calderón Guzmán, D; Espitia Vázquez, I; Juárez Olguín, H; Labra Ruiz, N; Rodríguez Pérez, R; Santamaria del Angel, D | 1 |
| Grady, MM; Stahl, SM | 1 |
| Costa, E; Grayson, DR; Guidotti, A | 1 |
| Gau, CS; Lin, CJ; Liou, HH; Shyu, MK; Wu, SP | 1 |
| Stahl, SM | 1 |
| Lopez, LM; Molloy, MS; Wassef, AA; Williams, NG | 1 |
| Dager, SR; Demopulos, C; Dunner, DL; Friedman, SD; Hirashima, F; Lyoo, IK; Parow, A; Renshaw, PF; Stoll, AL | 1 |
| Baldassano, CF; Ballas, CA; O'Reardon, JP | 1 |
| Altar, CA; Drabik, CE; Laeng, P; Lemire, AL; Mallon, BS; Pitts, RL; Tang, H; Thyagarajan, R; Weiner, A | 1 |
| Papp, Z; Török, L | 1 |
| Bossi, E; Giovannardi, S; Peres, A; Pisani, R; Soragna, A | 1 |
| Fedrowitz, M; Gernert, M; Löscher, W; Wlaz, P | 1 |
| Frediani, F | 1 |
| Aubry, JM; Moscianese, K; Navarra, P; Pozzoli, G; Preziosi, P; Tringali, G; Vairano, M; Zamori, C | 1 |
| Armijo, JA; Cuadrado, A | 1 |
| Calabrese, JR; Elhaj, O; Gajwani, P; Gao, K; Muzina, DJ | 1 |
| Book, SW; Myrick, H | 1 |
| Howland, RH | 1 |
| Berry, D; Millington, C | 1 |
| Raskind, MA; Rosin, RA | 1 |
| Alvey, CW; Bockbrader, HN; Brodie, MJ; Bron, NJ; Gibson, GL; Hounslow, NJ; Posvar, EL; Randinitis, EJ; Wesche, DL; Wilson, EA | 1 |
| Dainese, F; Maggioni, F; Mainardi, F; Ruffatti, S; Zanchin, G | 1 |
| Gobbi, G; Janiri, L | 1 |
| Hellings, JA | 1 |
| Bialer, M | 1 |
| Chang, K; Howe, M; Saxena, K; Simeonova, D; Steiner, H | 1 |
| Bröcker, EB; Pfeuffer, P; Raith, P; Seitz, CS; Trautmann, A | 1 |
| Costa, E; Dong, E; Grayson, DR; Guidotti, A; Ruzicka, WB; Simonini, MV; Veldic, M | 1 |
| Boon, AJ; de Gier, HH; Mondria, T | 1 |
| Calabresi, P; Cupini, LM; Galletti, F; Rossi, C; Sarchielli, P | 1 |
| Dodick, D; Hering-Hanit, R; Láinez, MJ; Pascual, J | 1 |
| Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A | 1 |
| Gieryk, A; Przewłocki, R; Schneider, T; Tyminska, A; Ziòłkowska, B | 1 |
| Jünemann, A; Michelson, G; Stefan, H; Tilz, C; Wang-Tilz, Y | 1 |
| Limmroth, V; Puppe, A | 1 |
| Collins, JC; McFarland, BH | 1 |
| Takahashi, Y | 1 |
| Kaur, G; Lakhanpal, D | 1 |
| Beghi, E; Brignoli, O; Caputi, AP; Cricelli, C; Innocenti, F; Mazzaglia, G; Musolino, R; Savica, R; Spina, E; Trifirò, G | 1 |
| Appleton, R; Baker, GA; Chadwick, DW; Doughty, J; Eaton, B; Gamble, C; Jacoby, A; Marson, AG; Shackley, P; Smith, DF; Tudur-Smith, C; Vanoli, A; Williamson, PR | 1 |
| Konovalov, S; Muralee, S; Tampi, RR | 1 |
| Carvalho, LB; Conti, CF; Oliveira, MM; Prado, GF; Prado, LB; Valbuza, JS | 1 |
| Sümegi, A | 1 |
| Pinheiro, D | 1 |
| Bondarenko, II | 2 |
| Costa, E; Dong, E; Grayson, DR; Guidotti, A; Kundakovic, M; Satta, R | 1 |
| Emrich, HM; Sieberer, M | 1 |
| Cuvellier, JC | 1 |
| Brignani, S; Contestabile, A; Eleuteri, S; Monti, B | 1 |
| Ruan, DY; Wang, S; Yong, W; Zhang, MM | 1 |
| Terbach, N; Williams, RS | 1 |
| Andreou, AP; Goadsby, PJ; Shields, KG | 1 |
| Hamada, J | 1 |
| Fountoulakis, K; Gonda, X; Rosa, AR; Siamouli, M; Vieta, E | 1 |
| Mula, M | 1 |
| Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM | 1 |
| Baumann, W; Buehler, SM; Gimsa, J; Koester, PJ; Niendorf, M; Stubbe, M; Tautorat, C | 1 |
| D'Amico, D | 1 |
| Bujoreanu, IS; DeMaso, DR; Ibeziako, P | 1 |
| Chateauvieux, S; Dicato, M; Diederich, M; Morceau, F | 1 |
| Kaneko, S; Motomura, E; Nakagawa, M; Ohoyama, K; Okada, M; Yamamura, S; Yoshida, S | 1 |
| Lang, SY; Shi, XB; Tian, HJ; Wang, RF; Wang, XQ; Yang, F | 1 |
| Desai, PV; Therisa, KK | 1 |
| Khanam, R; Pal, SN; Pillai, KK; Vohora, D | 1 |
| Kanner, AM | 1 |
| Feuerstein, TJ; Freiman, TM; Kammerer, M; Rassner, MP | 1 |
| Bittner, S; Göbel, K; Höhn, K; Kleinschnitz, C; Meuth, SG; Wiendl, H | 1 |
| Bhide, PG; Crandall, JE; Dräger, UC; Duester, G; Goodman, T; McCaffery, P; McCarthy, DM | 1 |
| Bosboom, WM; Iannaccone, ST; van den Berg, LH; Vrancken, AF; Wadman, RI; Wokke, JH | 1 |
| Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M | 1 |
| Bosboom, WM; Iannaccone, ST; van den Berg, LH; van der Pol, WL; Vrancken, AF; Wadman, RI; Wokke, JH | 1 |
| Kamal, SM | 1 |
| Dabole, B; Dawe, A; De Waard, M; Dimo, T; Djomeni Dzeufiet, PD; Ngo Bum, E; Okomolo Moto, FC; Sidiki, N; Sotoing Taïwe, G; Talla, E; Temkou Ngoupaye, G | 1 |
| Anderson, CM; Choi, YE; Eskandari, S; Maestas, MJ; Omoto, JJ; Rahnama-Vaghef, A; Salto, G; Sanchez, RV | 1 |
| Abe, M; Egashira, N; Fujiwara, M; Iwasaki, K; Mishima, K; Niki, T; Oishi, R; Shirakawa, A | 1 |
| Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A | 1 |
| Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM | 1 |
| Koo, J; Zavras, A | 1 |
| Akbarian, S; Halene, T; Hasan, A; Mitchell, A; Schneider, A | 1 |
| Belozertsev, FIu; Belozertsev, IuA; Iuntsev, SV; Zapol'skaia, IuA | 1 |
| Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R | 1 |
| Owada, K | 1 |
| Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN | 1 |
| Cavalleri, GL; Chukwu, J; Delanty, N; Webb, D | 1 |
| Ben-Ari, Y; Brouchoud, C; Burnashev, N; Chazal, G; Eftekhari, S; Ferrari, DC; Khalilov, I; Lemonnier, E; Lozovaya, N; Nardou, R; Shahrokhi, A; Tsintsadze, T; Tsintsadze, V; Tyzio, R | 1 |
| Bhandary, B; Chae, HJ; Jeong, SK; Kim, HR; Marahatta, A | 1 |
| Egashira, Y; Kumamaru, E; Takamori, S; Takenaka, R | 1 |
| Ikawa, K; Ikeda, K; Morikawa, N; Yokoshige, S; Yoshikawa, S | 1 |
| Ito, S; Oguni, H | 1 |
| Krysiak, R; Stojko, R | 1 |
| Cusmano, DM; Mong, JA | 1 |
| Deeb, S; Logan, BK; McKeown, DA; Scott, KS; Torrance, HJ; Wylie, FM | 1 |
| Baniasadi, M; Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A | 1 |
| Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J | 1 |
| Jimeno, FJ; Manso, G; Ordoñez, L; Salgueiro, E | 1 |
| Bártfai, G; Devosa, I; Szok, D; Vanya, M | 1 |
| Kumar, A; Piplani, S; Verma, PK | 1 |
| Kršková, L; Olexová, L; Štefánik, P | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK | 1 |
| Golding, AN; Houle, TT; Turner, DP | 1 |
| Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B | 1 |
| Coutellier, L; Heslin, K; Shepard, R | 1 |
| Beydemir, Ş; Demir, Y | 1 |
| He, A; Li, C; Song, D; Zhang, L | 1 |
| Jahan, K; Pillai, KK; Vohora, D | 1 |
| Li, Y; Peng, L; Zhao, Y; Zhou, Y | 1 |
| Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J | 2 |
| Androsova, G; Auce, P; Avbersek, A; Becker, F; Berghuis, B; Borghei, M; Campbell, E; Cavalleri, GL; Coppola, A; Craig, J; Delanty, N; Depondt, C; Francis, B; Koeleman, BPC; Krause, R; Kunz, WS; Lerche, H; Marson, AG; Sander, JW; Sills, GJ; Sisodiya, SM; Striano, P; Wassenaar, M; Wolking, S; Zara, F | 1 |
| Khongrum, J; Wattanathorn, J | 1 |
| Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA | 1 |
| Alabed, S; Bergman, H; Latifeh, Y; Mohammad, HA | 1 |
| Ala, M; Dehpour, AR; Ganjedanesh, MR; Mohammad Jafari, R; Nematian, H | 1 |
| Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ | 1 |
| Gifford, JJ; Kusnecov, AW; Norton, SA; Wagner, GC | 1 |
| Augustyniak, J; Lazarewicz, JW; Lenart, J; Zieminska, E | 1 |
| Colijn, MA | 1 |
| Yang, CH; Yang, JQ; Yin, BQ | 1 |
| Bahlo, M; Bello-Espinosa, LE; Bennett, MF; Berkovic, SF; Buchhalter, J; Chan, EK; D'Alfonso, S; Dabscheck, G; Damiano, JA; Grinton, BE; Hildebrand, MS; Myers, KA; Sadleir, LG; Scheffer, IE; Schneider, AL | 1 |
| Emad, S; Haider, S; Perveen, T; Qadeer, S; Sadaf, S; Sarfaraz, Y; Sheikh, S; Yousuf, S | 1 |
| Bansal, S; Batra, G; Jain, A; Medhi, B; Mishra, A; Modi, M; Saini, L; Sharma, AR; Sharma, S; Singh, A; Singh, RS; Singla, R | 1 |
| Aranđelović, J; Banićević, M; Batinić, B; Bijelić, D; Cook, JM; Santrač, A; Savić, MM; Sharmin, D; Stevanović, V | 1 |
| Kwan, KM; Ma, SY | 1 |
| Chen, PS; Chi, H; Chu, MC; Chung, YJ; Lee, CW; Lin, HC; Wu, HF | 1 |
| Bhatia, A; Jain, A; Joshi, R; Kaur, G; Kumar, R; Medhi, B; Mishra, A; Prakash, A; Sarma, P; Sharma, AR; Singla, R | 1 |
| Basaure, P; Biosca-Brull, J; Blanco, J; Cabré, M; Colomina, MT; Domingo, JL; Guardia-Escote, L; Sánchez-Santed, F | 1 |
| Andersson, Å; Keramidas, A; Kuanyshbek, A; Mu, TW; Palmer, EE; Sachdev, RK; Tuifua, M; Vetter, I; Wang, M | 1 |
| Du, Y; Jin, P; Tang, DQ; You, YX; Zhao, LL; Zhao, YL; Zheng, XX | 1 |
| Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M | 1 |
| Aboul-Fotouh, S; El-Salam, MFA; Elayat, WM; Elhossiny, RM; Habib, MZ; Hassan, GAM; Mohamad, MI; Zohny, SM | 1 |
110 review(s) available for valproic acid and gamma-aminobutyric acid
| Article | Year |
|---|---|
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Half-Life; Humans; Intestinal Absorption; Mice; Phenobarbital; Phenytoin; Seizures; Sleep Stages; Valproic Acid | 1979 |
Inhibitors of GABA metabolism.
Topics: 4-Aminobutyrate Transaminase; Animals; Cycloserine; Depression, Chemical; Ethanolamines; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Kinetics; Receptors, Drug; Valproic Acid | 1979 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Pregnancy; Valerates; Valproic Acid | 1977 |
Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Valproic Acid | 1990 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Anticonvulsant drugs: mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Biomechanical Phenomena; Carbamazepine; gamma-Aminobutyric Acid; Humans; Neurotransmitter Agents; Phenytoin; Primidone; Succinimides; Synapses; Synaptic Transmission; Valproic Acid | 1986 |
[Drug activation of GABAergic transmission in the central nervous system: benzodiazepines and GABAergic agonists].
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Carbolines; Chemical Phenomena; Chemistry; Cyclic GMP; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Synaptic Transmission; Valproic Acid | 1985 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
GABAergic control of anterior pituitary function in humans.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Diazepam; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Hyperprolactinemia; Hypothalamo-Hypophyseal System; Menstruation; Pituitary Gland, Anterior; Pituitary-Adrenal System; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone; Valproic Acid | 1986 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid | 1986 |
Petit mal epilepsy: a review and integration of recent information.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Brain; Cognition; Dementia; Electroencephalography; Electrophysiology; Epilepsy, Absence; Evoked Potentials; gamma-Aminobutyric Acid; Humans; Motor Skills; Norepinephrine; Prognosis; Sensation; Sodium Oxybate; Valproic Acid | 1986 |
Experimental studies and controlled clinical testing of valproate and vigabatrin.
Topics: Aminocaproates; Animals; Anticonvulsants; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Research Design; Valproic Acid; Vigabatrin | 1988 |
Determination of antiepileptic drugs.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, Gas; Chromatography, Liquid; Clonazepam; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Mephenytoin; Monitoring, Physiologic; Phenytoin; Primidone; Succinimides; Valproic Acid | 1985 |
[Mechanisms of action and biochemical toxicology of valproic acid].
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Ammonia; Animals; Anticonvulsants; Aspartic Acid; Brain; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Gluconeogenesis; Glutamate Decarboxylase; Humans; Hydroxybutyrate Dehydrogenase; Neurons; Receptors, Neurotransmitter; Valproic Acid | 1984 |
Mechanism of anticonvulsant action of valproate.
Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life; Humans; Intestinal Absorption; Kinetics; Mental Disorders; Mice; Movement Disorders; Neurotransmitter Agents; Protein Binding; Rabbits; Rats; Valproic Acid | 1982 |
The interaction between GABA and dopamine: implications for schizophrenia.
Topics: Animals; Antipsychotic Agents; Baclofen; Brain Chemistry; Catalepsy; Dopamine; gamma-Aminobutyric Acid; Humans; Motor Activity; Neural Pathways; Neurons; Rats; Receptors, Dopamine; Rotation; Schizophrenia; Sodium Oxybate; Stereotyped Behavior; Valproic Acid | 1983 |
Pharmacology of GABA.
Topics: 4-Aminobutyrate Transaminase; Anxiety Disorders; Autonomic Nervous System; Barbiturates; Benzodiazepines; Bipolar Disorder; Dyskinesia, Drug-Induced; Epilepsy; gamma-Aminobutyric Acid; Humans; Huntington Disease; Mental Disorders; Movement Disorders; Neural Inhibition; Parkinson Disease; Pituitary Gland, Anterior; Schizophrenia; Status Epilepticus; Substance Withdrawal Syndrome; Syndrome; Valproic Acid | 1982 |
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Corpus Striatum; Denervation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kainic Acid; Kinetics; Mesencephalon; Muscimol; Neuroglia; Neurons; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substantia Nigra; Tissue Distribution; Valproic Acid; Vigabatrin | 1981 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Aspartic Acid; Brain; Cyclic GMP; Dyskinesia, Drug-Induced; Electric Stimulation; Electrophysiology; Epilepsies, Partial; gamma-Aminobutyric Acid; Glycine; Humans; Nervous System Diseases; Neurons; Seizures; Serotonin; Succinate-Semialdehyde Dehydrogenase; Succinates; Valproic Acid | 1981 |
Effects of anticonvulsant drugs on brain amino acid metabolism.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Benzodiazepines; Biomechanical Phenomena; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Glutamates; Glycine; Humans; Neural Inhibition; Phenobarbital; Synapses; Valproic Acid | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
The mechanism of action of sodium valproate.
Topics: Animals; gamma-Aminobutyric Acid; Humans; Neurons; Time Factors; Valproic Acid | 1981 |
Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Mice; Phenylcarbamates; Propylene Glycols; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Triazines; Valproic Acid | 1994 |
[Sodium valproate--current status of pharmacological research].
Topics: Animals; Calcium; Dopamine; gamma-Aminobutyric Acid; Humans; Ion Channels; Rats; Serotonin; Sodium Oxybate; Valproic Acid | 1994 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; Drug Design; Epilepsy, Generalized; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Receptors, GABA-A; Receptors, Neurotransmitter; Sodium Channels; Triazines; Valproic Acid | 1993 |
Treatment of infantile spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Prednisone; Spasms, Infantile; Valproic Acid; Vigabatrin | 1994 |
[Sodium valproate--still a current antiepileptic agent?].
Topics: Aging; Drug Interactions; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Milk, Human; Pregnancy; Valproic Acid | 1994 |
Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Humans; N-Methylaspartate; Neurotransmitter Agents; Valproic Acid | 1993 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combination; Electroencephalography; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine; Valproic Acid | 1993 |
Mechanisms of action of antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; N-Methylaspartate; Neural Pathways; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1995 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calcium Channels; Carbamazepine; Central Nervous System; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Phenytoin; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium Channels; Triazines; Trimethadione; Valproic Acid; Vigabatrin | 1995 |
Mechanism of action of antiepileptic and antimyoclonic drugs.
Topics: Animals; Anticonvulsants; Barbiturates; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Humans; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1995 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Generalized; Felbamate; gamma-Aminobutyric Acid; Humans; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid; Vigabatrin | 1995 |
[Advantages and disadvantages of new antiepileptic drugs].
Topics: Acetates; Adrenocorticotropic Hormone; Amines; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Valproic Acid; Vigabatrin | 1996 |
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Ketone Bodies; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Triazines; Valproic Acid; Vigabatrin | 1997 |
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Exanthema; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Treatment Outcome; Triazines; Valproic Acid; Vigabatrin | 1997 |
Mood stabilizer combinations: a review of safety and efficacy.
Topics: Acetates; Amines; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Calcium Channel Blockers; Clinical Trials as Topic; Clozapine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium; Risperidone; Valproic Acid | 1998 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approval; Drug Design; Drug Interactions; Drug Resistance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Ketones; Lamotrigine; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Phenylcarbamates; Phenytoin; Prodrugs; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Valproic Acid; Vigabatrin | 1998 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexanecarboxylic Acids; Diazepam; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Mephenytoin; Pentobarbital; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Seizures; Valproic Acid | 1998 |
A mechanistic approach to antiepileptic drug interactions.
Topics: Acetates; Amines; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cyclohexanecarboxylic Acids; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glucuronosyltransferase; Humans; Lamotrigine; Mixed Function Oxygenases; Nipecotic Acids; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 1998 |
Special considerations: use of lithium in children, adolescents, and elderly populations.
Topics: Abnormalities, Drug-Induced; Acetates; Adolescent; Adult; Age Factors; Aged; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Male; Pregnancy; Triazines; Valproic Acid | 1998 |
Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder.
Topics: Acetates; Action Potentials; Amines; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Calcium Channel Blockers; Carrier Proteins; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Lamotrigine; Limbic System; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neural Inhibition; Neuronal Plasticity; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Sodium Channels; Synaptic Transmission; Triazines; Valproic Acid | 1998 |
Fortnightly review: drug treatment of epilepsy.
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Clobazam; Clonazepam; Cyclohexanecarboxylic Acids; Diethylcarbamazine; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Topiramate; Valproic Acid; Vigabatrin | 1999 |
Critical review of GABA-ergic drugs in the treatment of schizophrenia.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Dopamine; GABA Agents; gamma-Aminobutyric Acid; Humans; Neurons; Receptors, GABA; Schizophrenia; Valproic Acid | 1999 |
Options after the first antiepileptic drug has failed.
Topics: Acetates; Amines; Anticonvulsants; Attitude to Health; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Quality of Life; Treatment Failure; Treatment Outcome; Valproic Acid; Vigabatrin | 1999 |
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Practice Patterns, Physicians'; Triazines; Valproic Acid; Vigabatrin | 1999 |
Mood stabilizers during breastfeeding: a review.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Lamotrigine; Lithium; MEDLINE; Milk, Human; Pregnancy; Pregnancy Complications; Puerperal Disorders; Triazines; Valproic Acid | 2000 |
Therapeutic safety monitoring: what to look for and when to look for it.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Topiramate; Triazines; Valproic Acid; Vigabatrin | 2000 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diazepam; Drug Overdose; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Topiramate; Triazines; Valproic Acid | 2000 |
An ever-increasing pharmacopoeia for the management of patients with bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Electroconvulsive Therapy; Electromagnetic Phenomena; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Olanzapine; Pirenzepine; Risperidone; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2000 |
[Stiff-man syndrome].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Prognosis; Stiff-Person Syndrome; Valproic Acid | 2000 |
Novel treatments for bipolar disorder.
Topics: Acetates; Amines; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Fatty Acids, Omega-3; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Topiramate; Triazines; Valproic Acid | 2001 |
Effects of antimanic mood-stabilizing drugs on fetuses, neonates, and nursing infants.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Antimanic Agents; Benzodiazepines; Breast Feeding; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Fetus; Gabapentin; gamma-Aminobutyric Acid; Haloperidol; Humans; Infant, Newborn; Lithium; Mood Disorders; Olanzapine; Pirenzepine; Placenta; Pregnancy; Risk Factors; Valproic Acid | 2001 |
Cognitive side effects of anticonvulsants.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Mood Disorders; Topiramate; Triazines; Valproic Acid | 2001 |
Predictors of treatment response in bipolar disorders: evidence from clinical and brain imaging studies.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brain; Carbamazepine; gamma-Aminobutyric Acid; Humans; Lithium; Magnetic Resonance Imaging; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Valproic Acid | 2002 |
The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Randomized Controlled Trials as Topic; Topiramate; Triazines; Valproic Acid | 2001 |
Anticonvulsants for neuropathic pain and detoxification.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Inactivation, Metabolic; Lamotrigine; Neuralgia; Phenytoin; Substance Withdrawal Syndrome; Triazines; Valproic Acid | 1998 |
Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Lithium; Signal Transduction; Synaptic Transmission; Valproic Acid | 2002 |
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Epilepsy; Excitatory Amino Acids; gamma-Aminobutyric Acid; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Ion Channels; Neural Inhibition; Serotonin; Valproic Acid | 2002 |
[Stiff-person syndrome].
Topics: Animals; Autoantibodies; Autoimmunity; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Motor Neurons; Nerve Tissue Proteins; Prognosis; Stiff-Person Syndrome; Synaptic Transmission; Valproic Acid | 2002 |
The role of anticonvulsants in preventive migraine therapy.
Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Recurrence; Topiramate; Treatment Outcome; Valproic Acid | 2003 |
Absence seizures in children.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy, Absence; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Triazines; Valproic Acid | 2002 |
Antidepressant properties of anticonvulsant drugs for bipolar disorder.
Topics: Acetates; Affect; Amines; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Topiramate; Triazines; Valproic Acid | 2003 |
Treating bipolar depression.
Topics: Acetates; Affect; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium Compounds; Nipecotic Acids; Olanzapine; Oxcarbazepine; Pirenzepine; Tiagabine; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2003 |
Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Donepezil; Fatty Acids, Omega-3; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Lamotrigine; Lithium Carbonate; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Risperidone; Thiazoles; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2003 |
[Anticonvulsants in preventive therapy of migraine].
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Topiramate; Valproic Acid | 2003 |
A critical review of atypical antipsychotic utilization: comparing monotherapy with polypharmacy and augmentation.
Topics: Acetates; Amines; Anticonvulsants; Antipsychotic Agents; Clinical Trials as Topic; Clozapine; Cyclohexanecarboxylic Acids; Drug Utilization; Gabapentin; gamma-Aminobutyric Acid; Humans; Polypharmacy; Risperidone; Schizophrenia; Valproic Acid | 2004 |
Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
Topics: Animals; Brain; Cell Adhesion Molecules, Neuronal; Epigenesis, Genetic; Extracellular Matrix Proteins; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Humans; Methionine; Models, Neurological; Nerve Tissue Proteins; Neurons; Reelin Protein; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2003 |
Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Carbamazepine; Fructose; GABA Agonists; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Synapses; Tiagabine; Topiramate; Triazines; Valproic Acid | 2004 |
Rethinking the treatment paradigm for bipolar depression: the importance of long-term management.
Topics: Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Chronic Disease; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium Carbonate; Randomized Controlled Trials as Topic; Time; Topiramate; Triazines; Valproic Acid | 2004 |
Anticonvulsant drugs in primary headaches prophylaxis.
Topics: Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Topiramate; Triazines; Valproic Acid; Vigabatrin; Zonisamide | 2004 |
Absence seizures in children.
Topics: Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy, Absence; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Triazines; Valproic Acid | 2003 |
Absence seizures in children.
Topics: Adolescent; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy, Absence; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Triazines; Valproic Acid | 2004 |
Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder.
Topics: Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Randomized Controlled Trials as Topic; Secondary Prevention; Triazines; Valproic Acid | 2005 |
Novel anticonvulsants in the treatment of alcoholism.
Topics: Alcohol Deterrents; Alcoholism; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Ethanol; Gabapentin; gamma-Aminobutyric Acid; Humans; Randomized Controlled Trials as Topic; Secondary Prevention; Substance Withdrawal Syndrome; Valproic Acid | 2005 |
Anticonvulsant drug therapies.
Topics: Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Disorder; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nurse's Role; Oxcarbazepine; Patient Selection; Safety; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2005 |
Absence seizures in children.
Topics: Adolescent; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy, Absence; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Triazines; Valproic Acid | 2005 |
New antiepileptic drugs that are second generation to existing antiepileptic drugs.
Topics: Amines; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Design; Drug Evaluation, Preclinical; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Molecular Structure; Randomized Controlled Trials as Topic; Structure-Activity Relationship; Valproic Acid | 2006 |
Epigenetic targets in GABAergic neurons to treat schizophrenia.
Topics: Animals; Cerebral Cortex; Epigenesis, Genetic; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Structure; Neurons; Schizophrenia; Valproic Acid | 2006 |
Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Topiramate; Valproic Acid | 2007 |
Antiepileptic drugs for the treatment of chronic and episodic cluster headache: a review.
Topics: Amines; Anticonvulsants; Cluster Headache; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Receptors, GABA; Topiramate; Treatment Outcome; Valproic Acid | 2007 |
GABAergic drugs for the treatment of migraine.
Topics: Acute Disease; Amines; Animals; Cyclohexanecarboxylic Acids; Fructose; GABA Agents; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Neuroprotective Agents; Pregabalin; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Topiramate; Valproic Acid | 2007 |
[Neuromuscular disorders caused by adverse effects of antiepileptics].
Topics: Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Neuromuscular Diseases; Phenobarbital; Phenytoin; Topiramate; Valproic Acid; Zonisamide | 2007 |
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids; Dementia; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Neuropsychological Tests; Psychomotor Disorders; Triazines; Valproic Acid | 2008 |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review.
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Humans; Restless Legs Syndrome; Treatment Outcome; Valproic Acid | 2008 |
[Mood stabilizers--past, present and future].
Topics: Affect; Antimanic Agents; Bipolar Disorder; Calcium; Carbamazepine; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Lithium Compounds; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mood Disorders; Triazines; Valproic Acid | 2008 |
[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)].
Topics: Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dementia; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Psychomotor Agitation; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2008 |
[Empirical evidence for the use of anticonvulsants in personality disorders].
Topics: Amines; Anticonvulsants; Borderline Personality Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Personality Disorders; Pregabalin; Randomized Controlled Trials as Topic; Topiramate; Triazines; Valproic Acid | 2009 |
[Antiepileptic drugs for the prevention of pediatric migraine].
Topics: Adolescent; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Tolerance; Fructose; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Levetiracetam; Migraine Disorders; Piracetam; Placebos; Retrospective Studies; Topiramate; Treatment Failure; Valproic Acid | 2009 |
Structure-function studies for the panacea, valproic acid.
Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kinase 3; HIV Infections; Humans; Inositol; Ion Channels; Migraine Disorders; Mitogen-Activated Protein Kinases; Molecular Structure; Phospholipases A2; Phospholipids; Signal Transduction; Structure-Activity Relationship; Teratogens; Valproic Acid; Virus Latency | 2009 |
[Use of antiepileptic drugs for the preventive treatment of migraine].
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Humans; Ion Channels; Migraine Disorders; Premedication; Synaptic Transmission; Topiramate; Valproic Acid | 2009 |
Is anticonvulsant treatment of mania a class effect? Data from randomized clinical trials.
Topics: Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium Compounds; Oxcarbazepine; Randomized Controlled Trials as Topic; Topiramate; Triazines; Valproic Acid | 2011 |
New antiepileptic drugs: molecular targets.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Monitoring; Electroshock; Epilepsy; Ethosuximide; gamma-Aminobutyric Acid; Humans; Molecular Structure; Neurotransmitter Transport Proteins; Phenytoin; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Synaptic Transmission; Treatment Outcome; Valproic Acid | 2009 |
Psychiatric concerns in pediatric epilepsy.
Topics: Adolescent; Amines; Anxiety Disorders; Bipolar Disorder; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Cyclohexanols; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Mental Disorders; Norepinephrine; Pregabalin; Selective Serotonin Reuptake Inhibitors; Valproic Acid; Venlafaxine Hydrochloride; Young Adult | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase Inhibitors; Humans; Valproic Acid | 2010 |
Are antiepileptic drugs used in the treatment of migraine associated with an increased risk of suicidality?
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Labeling; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Risk Factors; Suicidal Ideation; Suicide; Topiramate; Treatment Outcome; United States; United States Food and Drug Administration; Valproic Acid | 2011 |
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohort Studies; Cyclohexanecarboxylic Acids; Disability Evaluation; Drug Therapy, Combination; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Male; Middle Aged; Mitoxantrone; Multiple Sclerosis; Neurologic Examination; Pregabalin; Retrospective Studies; Triazines; Valproic Acid; Young Adult | 2011 |
Drug treatment for spinal muscular atrophy types II and III.
Topics: Acetylcarnitine; Adolescent; Amines; Child; Child, Preschool; Creatine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyurea; Neuroprotective Agents; Phenylbutyrates; Randomized Controlled Trials as Topic; Spinal Muscular Atrophies of Childhood; Thyrotropin-Releasing Hormone; Valproic Acid | 2011 |
Drug treatment for spinal muscular atrophy types II and III.
Topics: Acetylcarnitine; Adolescent; Amines; Child; Child, Preschool; Creatine; Cyclohexanecarboxylic Acids; Disease Progression; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyurea; Neuroprotective Agents; Phenylbutyrates; Randomized Controlled Trials as Topic; Spinal Muscular Atrophies of Childhood; Thyrotropin-Releasing Hormone; Valproic Acid | 2012 |
Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors.
Topics: Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epigenesis, Genetic; gamma-Aminobutyric Acid; Histone Deacetylase Inhibitors; Histones; Humans; Protein Processing, Post-Translational; Schizophrenia; Valproic Acid | 2013 |
Weight change, genetics and antiepileptic drugs.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Humans; Medication Adherence; Obesity; Pregabalin; Sequence Analysis, DNA; Valproic Acid; Vigabatrin; Weight Gain | 2014 |
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Substitution; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Patient Education as Topic; Piracetam; Practice Guidelines as Topic; Topiramate; Triazines; Triazoles; Valproic Acid | 2014 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Oxcarbazepine; Parturition; Perinatal Care; Phenobarbital; Phenytoin; Piracetam; Preconception Care; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Teratogens; Triazines; Valproic Acid | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis.
Topics: Adult; Amines; Amitriptyline; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizziness; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Migraine Disorders; Nausea; Pre-Exposure Prophylaxis; Propranolol; Randomized Controlled Trials as Topic; Topiramate; Treatment Outcome; Valproic Acid | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
Gamma-aminobutyric acid agonists for antipsychotic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Dyskinesia, Drug-Induced; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Placebos; Randomized Controlled Trials as Topic; Valproic Acid | 2018 |
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety Disorders; Child; Contraindications, Drug; Developmental Disabilities; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Hallucinations; Humans; Neuroimaging; Phenotype; Psychotic Disorders; Psychotropic Drugs; Sleep Disorders, Intrinsic; Succinate-Semialdehyde Dehydrogenase; Symptom Assessment; Valproic Acid | 2020 |
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservatives; gamma-Aminobutyric Acid; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Propionates; Valproic Acid | 2022 |
51 trial(s) available for valproic acid and gamma-aminobutyric acid
| Article | Year |
|---|---|
Efficacies of agents related to GABA, dopamine, and acetylcholine in the treatment of tardive dyskinesia [proceedings].
Topics: Acetylcholine; Clinical Trials as Topic; Deanol; Dopamine; Dyskinesia, Drug-Induced; Ethanolamines; Female; gamma-Aminobutyric Acid; Humans; Indoles; Male; Middle Aged; Piperazines; Valerates; Valproic Acid | 1978 |
Huntington's disease: treatment with dipropylacetic acid and gamma-aminobutyric acid.
Topics: Adult; Aminobutyrates; Clinical Trials as Topic; Dopamine; Drug Evaluation; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; Middle Aged; Serotonin; Valerates; Valproic Acid | 1976 |
[Proposal for the introduction of a new substance into hospital practice: dipropyl acetate sodium in the prevention and treatment of alcoholic delirium].
Topics: Animals; Brain; Clinical Trials as Topic; Drug Evaluation; gamma-Aminobutyric Acid; Hospitalization; Humans; Psychoses, Alcoholic; Substance Withdrawal Syndrome; Valerates; Valproic Acid | 1977 |
Treatment of Parkinson's disease with sodium valproate: clinical, pharmacological, and biochemical observations.
Topics: Aged; Carbidopa; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Valproic Acid | 1979 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Pregnancy; Valerates; Valproic Acid | 1977 |
Stimulation of ACTH/cortisol by intravenously infused substance P in normal men: inhibition by sodium valproate.
Topics: Adrenocorticotropic Hormone; Adult; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Infusions, Intravenous; Male; Reference Values; Sodium Chloride; Substance P; Synaptic Transmission; Valproic Acid | 1992 |
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Muscle Relaxation; Pressure; Receptors, GABA-A; Valproic Acid | 1991 |
Reduction of baclofen-, but not sodium valproate-induced growth hormone release in type I diabetic men.
Topics: Adult; Baclofen; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Receptors, GABA-A; Valproic Acid | 1991 |
Inhibition by sodium valproate of the arginine vasopressin and adrenocorticotropin responses to angiotensin II in normal men.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Adult; Angiotensin II; Arginine Vasopressin; Enzyme Inhibitors; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid | 1989 |
The effect of magnesium valproate on plasma ACTH concentrations in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Nelson Syndrome; Time Factors; Valproic Acid | 1989 |
The effects of sodium valproate on plasma somatostatin and insulin in humans.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; gamma-Aminobutyric Acid; Humans; Insulin; Male; Middle Aged; Pancreatic Neoplasms; Somatostatin; Somatostatinoma; Valproic Acid | 1988 |
Impaired growth hormone response to sodium valproate in normal aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary Gland, Anterior; Synaptic Transmission; Valproic Acid | 1987 |
Involvement of endogenous gabaergic system in the modulation of gonadotropin secretion in normal cycling women.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Humans; Luteal Phase; Luteinizing Hormone; Menstrual Cycle; Progesterone; Valproic Acid | 1986 |
Growth hormone response to sodium valproate in chronic schizophrenia.
Topics: Adult; Brain; Chronic Disease; Double-Blind Method; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Middle Aged; Radioimmunoassay; Schizophrenia; Valproic Acid | 1986 |
Pharmacological evidence for a dual GABAergic regulation of growth hormone release in humans.
Topics: Adult; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Physical Exertion; Secretory Rate; Valproic Acid | 1986 |
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Patient Compliance; Phenytoin; Valproic Acid | 1986 |
Meige syndrome: double-blind crossover study of sodium valproate.
Topics: Basal Ganglia Diseases; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Meige Syndrome; Middle Aged; Valproic Acid | 1987 |
[Comparative study of sodium valproate and ketoprofen in the treatment of postoperative pain].
Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Ketoprofen; Male; Middle Aged; Pain, Postoperative; Phenylpropionates; Valproic Acid | 1988 |
Experimental studies and controlled clinical testing of valproate and vigabatrin.
Topics: Aminocaproates; Animals; Anticonvulsants; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Research Design; Valproic Acid; Vigabatrin | 1988 |
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid | 1983 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Isoxazoles; Muscimol; Substantia Nigra; Valproic Acid; Vigabatrin | 1983 |
Effects of the GABAergic drug, sodium valproate, on the prolactin release evoked by pharmacological stimuli in normal women.
Topics: Adult; Depression, Chemical; Domperidone; Female; gamma-Aminobutyric Acid; Humans; Prolactin; Sulpiride; Thyrotropin-Releasing Hormone; Valproic Acid | 1984 |
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Movement Disorders; Muscimol; Parkinson Disease; Valproic Acid | 1981 |
Sodium valproate in schizophrenia: some biochemical correlates.
Topics: Adult; Clinical Trials as Topic; gamma-Aminobutyric Acid; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Schizophrenia; Valproic Acid | 1980 |
Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Alcohol Withdrawal Delirium; Bipolar Disorder; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Lithium; Male; Middle Aged; Placebos; Propranolol; Valproic Acid | 1980 |
Opioid modulation of the gamma-aminobutyric acid-controlled inhibition of exercise-stimulated growth hormone and prolactin secretion in normal men.
Topics: Adult; Analysis of Variance; Exercise; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Naloxone; Prolactin; Reference Values; Valproic Acid | 1994 |
Plasma GABA predicts acute response to divalproex in mania.
Topics: Adult; Aged; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Lithium Carbonate; Male; Middle Aged; Treatment Outcome; Valproic Acid | 1996 |
Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans.
Topics: Adult; Anticonvulsants; Depression, Chemical; Double-Blind Method; Enzyme Multiplied Immunoassay Technique; Female; gamma-Aminobutyric Acid; Humans; Male; Melatonin; Valproic Acid | 1997 |
Different control mechanisms of growth hormone (GH) secretion between gamma-amino- and gamma-hydroxy-butyric acid: neuroendocrine evidence in Parkinson's disease.
Topics: Aged; Baclofen; GABA Agents; GABA Agonists; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Middle Aged; Parkinson Disease; Sodium Oxybate; Valproic Acid | 1997 |
Different sensitivity to sodium valproate in healthy, non-tumoral and tumoral hyperprolactinemic subjects.
Topics: Adolescent; Adult; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Hyperprolactinemia; Kinetics; Middle Aged; Pituitary Neoplasms; Prolactin; Prolactinoma; Valproic Acid | 1997 |
Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsies, Partial; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurologic Examination; Phenobarbital; Phenytoin; Primidone; Quality of Life; Valproic Acid | 1998 |
Long-term follow-up study of vigabatrin in pretreated children with West syndrome.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dexamethasone; Drug Therapy, Combination; Electroencephalography; Female; gamma-Aminobutyric Acid; Glucocorticoids; Humans; Infant; Male; Premedication; Prospective Studies; Pyridoxine; Spasms, Infantile; Treatment Outcome; Valproic Acid; Vigabatrin | 1998 |
[Therapeutic failure, treatment and non-treatment of childhood epilepsy].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Male; Treatment Outcome; Valproic Acid; Vigabatrin | 1998 |
Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Double-Blind Method; Drug Resistance; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Prospective Studies; Retreatment; Treatment Outcome; Valproic Acid; Vigabatrin | 1999 |
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.
Topics: Adult; Ammonia; Anticonvulsants; Astrocytes; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Occipital Lobe; Refractory Period, Electrophysiological; Valproic Acid | 1999 |
Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Brain Diseases; Child; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Finland; gamma-Aminobutyric Acid; Humans; Incidence; Magnetic Resonance Imaging; Spasms, Infantile; Tomography, X-Ray Computed; Treatment Outcome; Valproic Acid; Videotape Recording; Vigabatrin | 1999 |
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cyclohexanecarboxylic Acids; Dizziness; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Male; Patient Dropouts; Phenytoin; Prospective Studies; Treatment Outcome; Valproic Acid | 1999 |
Mania: gender, transmitter function, and response to treatment.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Female; gamma-Aminobutyric Acid; Humans; Lithium Carbonate; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid | 1999 |
Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium Carbonate; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid | 2000 |
Topiramate as add-on treatment for patients with bipolar mania.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Body Mass Index; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium; Male; Middle Aged; Topiramate; Treatment Outcome; Valproic Acid | 1999 |
Visual cortex excitability in migraine before and after valproate prophylaxis: a pilot study using TMS.
Topics: Anticonvulsants; Electromagnetic Fields; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Migraine Disorders; Migraine with Aura; Pilot Projects; Valproic Acid; Visual Cortex | 2002 |
The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Randomized Controlled Trials as Topic; Topiramate; Triazines; Valproic Acid | 2001 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid | 2003 |
Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder.
Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Brain Mapping; Case-Control Studies; Echo-Planar Imaging; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Lactic Acid; Lithium; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Valproic Acid | 2004 |
Analysis of pregabalin at therapeutic concentrations in human plasma/serum by reversed-phase HPLC.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Drug Stability; Drug Therapy, Combination; Epilepsy; gamma-Aminobutyric Acid; Humans; Lamotrigine; Pregabalin; Reproducibility of Results; Spectrophotometry, Ultraviolet; Triazines; Trinitrobenzenesulfonic Acid; Valproic Acid | 2005 |
Weight variations in the prophylactic therapy of primary headaches: 6-month follow-up.
Topics: Adrenergic beta-Antagonists; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Atenolol; Cyclohexanecarboxylic Acids; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Migraine with Aura; Migraine without Aura; Pizotyline; Propranolol; Tension-Type Headache; Valproic Acid; Vasodilator Agents; Verapamil; Weight Gain | 2005 |
Much improved outcome with gabapentin-divalproex combination in adults with bipolar disorders and developmental disabilities.
Topics: Adolescent; Adult; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Developmental Disabilities; Drug Combinations; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid | 2006 |
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Cyclothymic Disorder; Depressive Disorder, Major; Dysthymic Disorder; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Risk Factors; Valproic Acid | 2006 |
A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Health Status Indicators; Humans; Lamotrigine; Male; Oxcarbazepine; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2007 |
Experience in the use of the anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Databases as Topic; Drug Therapy, Combination; Epilepsies, Partial; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Russia; Seizures; Time Factors; Treatment Outcome; Valproic Acid; Young Adult | 2010 |
Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Anxiety; Combat Disorders; Depression; Double-Blind Method; Drug Synergism; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Quality of Life; Stress Disorders, Post-Traumatic; Treatment Outcome; Valproic Acid | 2014 |
403 other study(ies) available for valproic acid and gamma-aminobutyric acid
| Article | Year |
|---|---|
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzhydryl Compounds; Blood-Brain Barrier; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Structure-Activity Relationship | 1992 |
Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Male; Mice; Pyrrolidinones; Rats; Receptors, GABA-A; Seizures; Sleep; Structure-Activity Relationship | 1991 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Topics: Caffeic Acids; Carboxylic Acids; Catalytic Domain; Chlorogenic Acid; Curcumin; Enzyme Inhibitors; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Structure; Protein Binding | 2009 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Central actions of valproate sodium.
Topics: Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Glycine; Neurons; Rats; Substantia Nigra; Time Factors; Valproic Acid | 1979 |
[Modification of curarization after acute administration of 2 antiepileptic drugs].
Topics: Animals; Anticonvulsants; Carbamazepine; Cyclic AMP; Drug Synergism; gamma-Aminobutyric Acid; Male; Neuromuscular Nondepolarizing Agents; Pancuronium; Pentobarbital; Pyridinium Compounds; Rats; Valproic Acid | 1979 |
gamma-Aminobutyric-acid deficiency in schizophrenia.
Topics: Aminobutyrates; gamma-Aminobutyric Acid; Humans; Schizophrenia; Valerates; Valproic Acid | 1976 |
Gabergic compounds and schizophrenia.
Topics: Baclofen; gamma-Aminobutyric Acid; Humans; Schizophrenia; Valproic Acid | 1976 |
Electrophysiological and behavioural correlations during the manipulations of GABA functions in the substantia nigra by n-dipropylacetate and picrotoxin.
Topics: Animals; Brain Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Substantia Nigra; Time Factors; Valproic Acid | 1979 |
Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Brain; Cattle; Chromatography, Affinity; gamma-Aminobutyric Acid; Kinetics; Succinate-Semialdehyde Dehydrogenase (NADP+); Valproic Acid | 1978 |
[Domestically produced sodium n-dipropylacetate in treating epilepsy (author's transl)].
Topics: Adolescent; Adult; Brain Chemistry; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Valproic Acid | 1979 |
Sodium valproate in chorea.
Topics: Aged; Brain; Female; Gait; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; Movement; Valerates; Valproic Acid | 1976 |
Sodium valproate in chorea.
Topics: Adult; Aged; Brain Chemistry; gamma-Aminobutyric Acid; Humans; Huntington Disease; Middle Aged; Valerates; Valproic Acid | 1976 |
Monoamine and GABA metabolism and the anticonvulsant action of di-n-propylacetate and ethanolamine-O-sulphate.
Topics: Acoustic Stimulation; Aminobutyrates; Animals; Anticonvulsants; Biogenic Amines; Brain Chemistry; Drug Interactions; Ethanolamines; Fenclonine; gamma-Aminobutyric Acid; Methyltyrosines; Mice; Mice, Inbred DBA; Probenecid; Valerates; Valproic Acid | 1977 |
[Effects of sodium n-dipropylacetate on the GABA level in various areas of the mouse brain].
Topics: Aminobutyrates; Animals; Brain; Caudate Nucleus; Cerebellum; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Medulla Oblongata; Mice; Olfactory Bulb; Pons; Valerates; Valproic Acid | 1976 |
Isoniazid and Huntington's chorea.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Rats; Valproic Acid | 1978 |
Biochemical effects in man and rat of three drugs which can increase brain GABA content.
Topics: Acetates; Adult; Amino Acids; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Rats; Valerates; Valproic Acid | 1978 |
Pharmacology of Huntington's chorea. Personal experience.
Topics: Acetates; Adult; Aminobutyrates; Blood Cell Count; Bromocriptine; Female; gamma-Aminobutyric Acid; Haloperidol; Humans; Huntington Disease; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Physostigmine; Receptors, Dopamine; Valerates; Valproic Acid | 1977 |
Inhibitors of GABA metabolism: implications for Huntington's disease.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminocaproic Acid; Animals; Caudate Nucleus; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huntington Disease; Kainic Acid; Male; Nerve Degeneration; Rats; Substantia Nigra; Transaminases; Valproic Acid | 1977 |
Suppression of GABA-induced abstinence behaviour in naive rats by morphine and bicuculline.
Topics: Aminobutyrates; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoquinolines; Male; Morphine; Motor Activity; Naloxone; Rats; Receptors, Drug; Receptors, Opioid; Substance Withdrawal Syndrome; Valerates; Valproic Acid | 1977 |
Gamma-aminobutyric acid (GABA) and sleep. The influence of di-n-propylacetic acid on sleep in man.
Topics: Adult; Aminobutyrates; Brain; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Male; Sleep; Sleep, REM; Time Factors; Valerates; Valproic Acid | 1977 |
[Effect of sodium n-dipropylacetate (sodium valproate) on GABA level of neuronal and glial cells in culture].
Topics: Animals; Astrocytoma; Bucladesine; Cell Line; gamma-Aminobutyric Acid; Kinetics; Neuroblastoma; Rats; Valproic Acid | 1978 |
Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucose; Isoniazid; Lactates; Male; Mice; Seizures; Valproic Acid | 1979 |
Suppression of retinal spike discharge by dipropylacetate (Depakene): a possible involvement of GABA.
Topics: Animals; Bicuculline; Carps; Evoked Potentials; gamma-Aminobutyric Acid; Neural Inhibition; Photic Stimulation; Retina; Synaptic Transmission; Valproic Acid | 1979 |
[On the mechanism of action of valproid acid].
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain Chemistry; Enzyme Activation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Mice; Valerates; Valproic Acid | 1977 |
[Psychological dependence? A possible different formulation of the problem for a therapeutic rearrangement in chronic drug addictions].
Topics: Antidepressive Agents; gamma-Aminobutyric Acid; Glutamine; Humans; Piracetam; Substance-Related Disorders; Valproic Acid | 1977 |
Effects of sodium dipropylacetate on gamma-aminobutyric acid and biogenic amines in rat brain.
Topics: Aminobutyrates; Animals; Biogenic Amines; Brain Chemistry; gamma-Aminobutyric Acid; Male; Rats; Valerates; Valproic Acid | 1977 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
beta-Alanine and gamma-aminobutyric acid contents of rat brain; post-mortem changes and effects of aminooxyacetic acid and di-n-propylacetate.
Topics: 4-Aminobutyrate Transaminase; Alanine; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Postmortem Changes; Rats; Time Factors; Transaminases; Valproic Acid | 1978 |
Time course of the increase in GABA level in different mice brain regions following N-dipropylacetate treatment.
Topics: Aminobutyrates; Animals; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Microwaves; Time Factors; Valerates; Valproic Acid | 1978 |
Gabaminergic and serotonergic modulation of the antidyskinetic effects of tiapride and oxiperomide in the model using 2-(N,N-dipropyl)animo-5,6-dihydroxytetralin.
Topics: 2-Naphthylamine; Aminobutyrates; Animals; Behavior, Animal; Benzamides; Benzimidazoles; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Guinea Pigs; Injections, Intraventricular; Male; Movement Disorders; Naphthalenes; Quipazine; Serotonin; Tetrahydronaphthalenes; Time Factors; Tranquilizing Agents; Valproic Acid | 1978 |
Dopaminergic, GABA-ergic and cholinergic interaction in the regulation of striatal acetylcholine concentration.
Topics: Acetylcholine; Aminooxyacetic Acid; Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Male; Muscimol; Parasympathetic Nervous System; Rats; Time Factors; Valproic Acid | 1978 |
Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Noise; Seizures; Valproic Acid | 1978 |
Effect of n-dipropylacetate on the consolidation of a brightness discrimination.
Topics: Animals; Discrimination, Psychological; gamma-Aminobutyric Acid; Hippocampus; Injections; Light; Male; Rats; Valproic Acid | 1978 |
Anticonvulsant activity and effects of sodium dipropylacetate on cerebral 5-hydroxytryptamine and gamma-aminobutyric acid in reserpinized mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Mice; Reserpine; Serotonin; Valproic Acid | 1978 |
GABA in plasma and cerebrospinal fluid of different species. Effects of gamma-acetylenic GABA, gamma-vinyl GABA and sodium valproate.
Topics: Acetylene; Animals; Cats; Dogs; Female; gamma-Aminobutyric Acid; Humans; Male; Rats; Valproic Acid; Vinyl Compounds | 1979 |
Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Brain; gamma-Aminobutyric Acid; Kinetics; Male; Mathematics; Rats; Succinates; Transaminases; Valproic Acid | 1979 |
Effect of drugs on rat brain, cerebrospinal fluid and blood GABA content.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Male; Organ Specificity; Rats; Valproic Acid | 1979 |
[Effect of GABA-ergic substances on the analgesic effect of morphine in rats].
Topics: Analgesia; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Male; Morphine; Rats; Receptors, Drug; Thiosemicarbazones; Time Factors; Valproic Acid; Vocalization, Animal | 1979 |
Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamates; Glycine; Mice; Neural Inhibition; Neurons; Spinal Cord; Synapses; Valproic Acid | 1979 |
Sodium di-n-propylacetate (valproate) action on single neurons in rat cerebral cortex and hippocampus.
Topics: Acetylcholine; Animals; Cerebral Cortex; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Male; Neurons; Parietal Lobe; Rats; Somatosensory Cortex; Valproic Acid | 1979 |
Effects of sodium valproate and ethanolamine-o-sulphate on GABA metabolism in vivo [proceedings].
Topics: Animals; Ethanolamines; Female; gamma-Aminobutyric Acid; Male; Mice; Valproic Acid | 1979 |
Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo.
Topics: Aminooxyacetic Acid; Animals; gamma-Aminobutyric Acid; Male; Nerve Endings; Nerve Tissue Proteins; Rats; Substantia Nigra; Valproic Acid | 1979 |
The effect of corticosteroids on amino acid content of brain tissue preparations.
Topics: Adrenal Cortex Hormones; Amino Acids; Animals; Brain; Culture Techniques; Dexamethasone; Estradiol; Ethinyl Estradiol; gamma-Aminobutyric Acid; Hydrocortisone; Mice; Progesterone; Valproic Acid | 1979 |
Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons.
Topics: Animals; Cells, Cultured; Drug Synergism; gamma-Aminobutyric Acid; Mice; Neural Inhibition; Spinal Cord; Valproic Acid | 1978 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Muscimol; Picrotoxin; Rats; Seizures; Structure-Activity Relationship; Valproic Acid | 1979 |
Metabolic inhibitors and subcellular distribution of GABA.
Topics: 3-Mercaptopropionic Acid; Aminocaproates; Animals; Anticonvulsants; Aromatic-L-Amino-Acid Decarboxylases; Aspartic Acid; Centrifugation, Density Gradient; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Male; Mice; Pyridoxal Phosphate; Synaptosomes; Valproic Acid | 1979 |
Effect of di-n-propylacetate on the 'binding of GABA to synaptosome-enriched fraction of rat cerebral cortex.
Topics: Aminobutyrates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nerve Tissue Proteins; Rats; Synaptosomes; Valerates; Valproic Acid | 1977 |
Failure of increased brain gamma-aminobutyric acid levels to influence amphetamine-induced stereotyped behavior.
Topics: Aminobutyrates; Amphetamine; Animals; Behavior; Brain; Brain Chemistry; Drug Interactions; gamma-Aminobutyric Acid; Guinea Pigs; Humans; Male; Stereotyped Behavior; Valproic Acid | 1975 |
Proceedings: gamma-Aminobutyric acid metabolism and the anticonvulsant action of ethanolamine-o-sulphate and di-n-propylacetate.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Chick Embryo; Ethanolamines; gamma-Aminobutyric Acid; Mice; Mice, Inbred DBA; Valerates; Valproic Acid | 1976 |
Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of gamma-aminobutyric acid (GABA) in mice with audiogenic seizures.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aldehyde Oxidoreductases; Aminobutyrates; Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Ethanolamines; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Seizures; Valerates; Valproic Acid | 1976 |
The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Rats; Seizures; Substance Withdrawal Syndrome; Valerates; Valproic Acid | 1976 |
Effects of chronic treatment with amino-oxyacetic acid or sodium n-dipropylacetate on brain GABA levels and the development and regression of cobalt epileptic foci in rats.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; Brain Chemistry; Cerebral Cortex; Cobalt; Electroencephalography; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Rats; Seizures; Time Factors; Valerates; Valproic Acid | 1976 |
[The effect of substnaces altering gamma-aminobutyric acid metabolism on the recovery cycle of the interzonal response of the cat motor cortex].
Topics: Aminobutyrates; Animals; Arecoline; Bemegride; Benactyzine; Bicuculline; Caffeine; Cats; Drug Interactions; Electrophysiology; gamma-Aminobutyric Acid; Motor Cortex; Receptors, Drug; Semicarbazides; Somatosensory Cortex; Sulfhydryl Compounds; Valproic Acid | 1975 |
Effect of drug-induced increase of brain GABA levels on penicillin focus.
Topics: Acetates; Action Potentials; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain Chemistry; Cats; Cerebral Cortex; Electroencephalography; Female; gamma-Aminobutyric Acid; Male; Penicillins; Rats; Seizures; Valproic Acid | 1975 |
Regional distribution in brain and effect on cerebral mitochondrial respiration of the anticonvulsive drug n-dipropylacetate.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mitochondria; Oxygen Consumption; Phenobarbital; Valerates; Valproic Acid | 1975 |
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Culture Techniques; Epilepsy; gamma-Aminobutyric Acid; Isoniazid; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Synaptic Transmission; Valproic Acid | 1992 |
Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Rats, Inbred Strains; Valproic Acid | 1992 |
The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study.
Topics: Amino Acids; Animals; Dialysis; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Rats, Wistar; Valproic Acid | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonazepam; Disease Susceptibility; Electroencephalography; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Organ Specificity; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1992 |
Valproic acid for nonaffective aggression in the mentally retarded.
Topics: Adult; Affect; Aggression; Animals; Female; gamma-Aminobutyric Acid; Humans; Intellectual Disability; Middle Aged; Rats; Valproic Acid | 1992 |
Sodium valproate and clonazepam for treatment-resistant panic disorder.
Topics: Adult; Agoraphobia; Clonazepam; Drug Synergism; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Male; Panic Disorder; Valproic Acid | 1992 |
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Exploratory Behavior; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Social Behavior; Valproic Acid | 1991 |
Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats.
Topics: Animals; Blood Pressure; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Hypertension; Hypothalamus; Injections; Injections, Intraventricular; Male; Muscimol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System; Valproic Acid | 1990 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Pentylenetetrazole; Probenecid; Rats; Rats, Inbred Strains; Serotonin; Valproic Acid | 1990 |
Influence of sodium valproate on late follicular phase pulsatile LH secretion in normal women.
Topics: Adult; Drug Administration Schedule; Estradiol; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Luteinizing Hormone; Progesterone; Secretory Rate; Time Factors; Valproic Acid | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Effect of selective bilateral destruction of the substantia nigra on antiepileptic drug actions in kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Diazepam; Electrodes; Female; gamma-Aminobutyric Acid; Ibotenic Acid; Kindling, Neurologic; Phenobarbital; Rats; Rats, Inbred Strains; Substantia Nigra; Synaptic Transmission; Valproic Acid | 1990 |
Effects of anticonvulsants and gamma-aminobutyric acid (GABA)-mimetic drugs on immunoreactive somatostatin and GABA contents in the rat brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, Gel; Drug Interactions; Ethanolamines; gamma-Aminobutyric Acid; Male; Muscimol; Phenytoin; Rats; Rats, Inbred Strains; Somatostatin; Valproic Acid | 1990 |
Valproate potentiates and picrotoxin antagonizes the anxiolytic action of ethanol in a nonshock conflict task.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Drug Synergism; Ethanol; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid | 1990 |
Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Ulcer Agents; Bicuculline; Cimetidine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Rats; Stomach Ulcer; Valproic Acid | 1990 |
Transport of valproate and its effects on GABA uptake in astroglial primary culture.
Topics: Animals; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Osmolar Concentration; Potassium; Sodium; Time Factors; Valproic Acid | 1990 |
A presumptive role for GABA in the stimulatory effects of Des-Gly10, [D-Ala6]-LHRH-ethylamide and pimozide on the gonadotropin release in carp.
Topics: 3-Mercaptopropionic Acid; Animals; Carps; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Gonadotropins; Male; Pimozide; Sperm Count; Valproic Acid | 1990 |
The anticonvulsant valproic acid concentrates in the olfactory bulb: selective laminar localization.
Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Olfactory Bulb; Rats; Valproic Acid | 1990 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepam; Electroshock; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials; Mice; Neurons; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1985 |
GABA mimetics decrease extracellular concentrations of 5-HIAA (as measured by in vivo voltammetry) in the dorsal raphe of the rat.
Topics: Animals; Brain Stem; Corpus Striatum; Electrochemistry; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Depression of hippocampal low calcium field bursts by the antiepileptic drug valproic acid.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Valproic Acid | 1985 |
Biochemistry and therapeutics of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Humans; Hydroxyindoleacetic Acid; Hypoxia; Methysergide; Models, Biological; Myoclonus; Prednisone; Serotonin; Tryptophan; Valproic Acid | 1986 |
Possible mechanisms of action of valproic acid in myoclonus.
Topics: 4-Aminobutyrate Transaminase; 5-Hydroxytryptophan; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Hydroxyindoleacetic Acid; Myoclonus; Pyridoxal Kinase; Rats; Serotonin; Tryptophan; Valproic Acid | 1986 |
[Elimination of disorders in the electrical stability of the heart during postinfarct cardiosclerosis by using a factor that induces GABA accumulation in the brain].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brain; Drug Evaluation, Preclinical; Electrocardiography; gamma-Aminobutyric Acid; Heart; Male; Myocardial Infarction; Myocardium; Rats; Rats, Inbred Strains; Sclerosis; Valproic Acid | 1989 |
Valproate enhances GABA turnover in the substantia nigra.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; Rats; Rats, Inbred Strains; Substantia Nigra; Valproic Acid | 1989 |
GABAergic agents-induced antinociceptive effect in mice.
Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; Muscimol; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Valproic Acid | 1989 |
Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Substantia Nigra; Valproic Acid | 1989 |
GABAA receptors in the rat stomach may mediate mucoprotective effects.
Topics: Administration, Oral; Aminooxyacetic Acid; Animals; Anti-Ulcer Agents; Baclofen; Bicuculline; Binding, Competitive; Ethanol; gamma-Aminobutyric Acid; Gastric Mucosa; Ligands; Muscimol; Rats; Receptors, GABA-A; Stomach Ulcer; Vagotomy; Valproic Acid | 1989 |
[Mechanism of action of antiepileptic drugs].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; gamma-Aminobutyric Acid; Ion Exchange; Phenobarbital; Phenytoin; Receptors, Neurotransmitter; Synaptic Transmission; Valproic Acid | 1987 |
Sodium valproate decreases exploratory behaviour in mice: development of tolerance and cross-tolerance with chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Receptors, GABA-A; Valproic Acid | 1988 |
Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man.
Topics: Adrenocorticotropic Hormone; Adult; Arginine Vasopressin; Ergolines; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hypoglycemia; Insulin; Male; Metergoline; Naloxone; Valproic Acid | 1988 |
Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro.
Topics: Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Locus Coeruleus; Male; Muscimol; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Valproic Acid | 1988 |
Central GABA-ergic mechanism in stress-induced gastric ulceration.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Neurotransmitter Agents; Picrotoxin; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Valproic Acid | 1985 |
Comparison of the pharmacological and biochemical profiles of valproic acid (VPA) and its cerebral metabolite (2-en-VPA) after oral administration in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Chemistry; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; gamma-Aminobutyric Acid; Kinetics; Mice; Valproic Acid | 1985 |
[Anxiolytic action of sodium valproate (possible role of gamma-aminobutyric acid in affective disorders)].
Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Brain; Cats; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurocognitive Disorders; Neurotic Disorders; Personality Disorders; Schizophrenia; Synaptic Transmission; Valproic Acid | 1985 |
Effects of anticonvulsant drugs on brain cultures from chick embryos: a comparison with cultures from embryos treated in ovo.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain; Carbonic Anhydrases; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Kinetics; Neurons; Phenobarbital; Phenytoin; Valproic Acid | 1985 |
Protective effect of GABA and sodium valproate on stress-induced gastric lesions in guinea-pigs.
Topics: Animals; Cold Temperature; Female; gamma-Aminobutyric Acid; Guinea Pigs; Injections, Intraperitoneal; Male; Restraint, Physical; Stomach Ulcer; Stress, Physiological; Valproic Acid | 1985 |
[Mechanism of the tranquilizing action of electron structural analogs of nicotinamide].
Topics: Animals; Benzodiazepinones; Bicuculline; Brain; Conflict, Psychological; Flumazenil; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inosine; Male; Niacinamide; Radioligand Assay; Rats; Receptors, GABA-A; Serotonin; Synaptosomes; Tranquilizing Agents; Valproic Acid | 1986 |
Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats.
Topics: Amygdala; Animals; Brain Chemistry; Carbamazepine; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; Somatostatin; Valproic Acid | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA.
Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Brain; Clonazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Receptors, GABA-A; Valproic Acid | 1988 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Evidence that a GABAergic mechanism influences the development of obesity in obese Zucker rats.
Topics: Animals; beta-Endorphin; Body Weight; gamma-Aminobutyric Acid; Insulin; Obesity; Rats; Rats, Zucker; Valproic Acid | 1988 |
Some anticonvulsant drugs alter monoamine-mediated behaviour in mice in ways similar to electroconvulsive shock; implications for antidepressant therapy.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Antidepressive Agents; Apomorphine; Behavior, Animal; Biogenic Amines; Clonidine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Radioligand Assay; Receptors, Adrenergic, beta; Receptors, Serotonin; Valproic Acid | 1985 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female; gamma-Aminobutyric Acid; Hypothermia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
Effects of valproic acid in cultured mammalian neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Drug Interactions; Electrophysiology; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Neurons; Pregnancy; Rats; Receptors, GABA-A; Valproic Acid | 1986 |
Failure of the GABAergic drug, sodium valproate, to reduce basal plasma prolactin secretion in chronic schizophrenia.
Topics: Adult; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Middle Aged; Prolactin; Schizophrenia; Synaptic Transmission; Valproic Acid | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
GABA and circadian timekeeping: implications for manic-depression and sleep disorders.
Topics: 4-Aminobutyrate Transaminase; Acetylcholine; Aldehyde Oxidoreductases; Animals; Benzodiazepines; Bipolar Disorder; Carbamazepine; Circadian Rhythm; Enzyme Induction; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Humans; Hypothalamus, Middle; Lithium; Models, Biological; Receptors, GABA-A; Sleep Wake Disorders; Succinate-Semialdehyde Dehydrogenase; Suprachiasmatic Nucleus; Valproic Acid | 1986 |
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Motor Activity; Muscimol; Nipecotic Acids; Olfactory Bulb; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Valproic Acid; Vigabatrin | 1986 |
Role of the substantia nigra in GABA-mediated anticonvulsant actions.
Topics: Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Brain Diseases; Denervation; Disease Susceptibility; Efferent Pathways; gamma-Aminobutyric Acid; Humans; Injections; Mesencephalon; Nerve Endings; Nerve Tissue Proteins; Reaction Time; Seizures; Substantia Nigra; Synaptic Transmission; Valproic Acid; Vigabatrin | 1986 |
[Decrease of plasma prolactin in valproate therapy--expression of an increase in the activity of the central GABAergic system].
Topics: Adolescent; Brain; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; Humans; Male; Prolactin; Receptors, GABA-A; Valproic Acid | 1987 |
Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.
Topics: Action Potentials; Animals; Carbamazepine; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Ethosuximide; gamma-Aminobutyric Acid; Magnesium; Mice; Neurons; Phenytoin; Seizures; Sodium; Spinal Cord; Valproic Acid | 1986 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid | 1986 |
Gamma-aminobutyric acid and the high pressure neurological syndrome.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Central Nervous System Diseases; Electrodes, Implanted; Electroencephalography; gamma-Aminobutyric Acid; High Pressure Neurological Syndrome; Male; Myoclonus; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Tremor; Valproic Acid | 1986 |
Valproate-induced accumulation of gamma-aminobutyric acid after chronic exposure to inorganic lead.
Topics: Animals; Brain Chemistry; Drug Interactions; gamma-Aminobutyric Acid; Globus Pallidus; Lead; Rats; Substantia Nigra; Tegmentum Mesencephali; Valproic Acid | 1986 |
Interaction between gabaergic and opioid pathways in the regulation of gonadotropin secretion in males.
Topics: Adult; Endorphins; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Humans; Luteinizing Hormone; Male; Naloxone; Valproic Acid | 1986 |
Evidence for the participation of a cytosolic NADP+-dependent oxidoreductase in the catabolism of gamma-hydroxybutyrate in vivo.
Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Glucuronates; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Keto Acids; Kidney; Male; Muscles; Phenylacetates; Rats; Rats, Inbred Strains; Sodium Oxybate; Sodium Salicylate; Valproic Acid | 1987 |
Naloxone reverses the inhibition by sodium valproate of GABA transport across the Deiters' neuronal plasma membrane.
Topics: Animals; Cell Membrane; gamma-Aminobutyric Acid; In Vitro Techniques; Naloxone; Rabbits; Valproic Acid; Vestibular Nuclei; Vestibular Nucleus, Lateral | 1987 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Food intake and antiepileptic drugs: evidence for a role of GABA in circadian time keeping.
Topics: Animals; Circadian Rhythm; Eating; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Suprachiasmatic Nucleus; Valproic Acid | 1987 |
[Prevention of arrhythmias and cardiac fibrillation in acute ischemia and reperfusion by using a factor causing GABA accumulation in the brain].
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Brain; Coronary Disease; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Valproic Acid; Ventricular Fibrillation | 1987 |
The inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid.
Topics: Animals; Carboxylic Acids; Clofibrate; gamma-Aminobutyric Acid; Kinetics; Liver; Male; Microbodies; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Valproic Acid | 1987 |
Bidirectional effects of beta-carbolines in reflex epilepsy.
Topics: Animals; Anticonvulsants; Brain; Carbolines; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Papio; Valproic Acid | 1987 |
Valproate enhances inhibitory postsynaptic potentials in hippocampal neurons in vitro.
Topics: Animals; Bicuculline; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Picrotoxin; Synapses; Valproic Acid | 1987 |
Relations between GABAergic and enkephalinergic systems: effects of sodium valproate on rat brain enkephalins.
Topics: Animals; Brain; Enkephalins; gamma-Aminobutyric Acid; Male; Models, Neurological; Organ Specificity; Rats; Rats, Inbred Strains; Valproic Acid | 1986 |
Oxidation of gamma-hydroxybutyrate to succinic semialdehyde by a mitochondrial pyridine nucleotide-independent enzyme.
Topics: Animals; Brain; Carbon Dioxide; Cytosol; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Immunoassay; Kidney; Male; Mitochondria; NAD; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sodium Oxybate; Valproic Acid | 1988 |
Pharmacological evidence that effects of vasotocin on brain maturation are mediated by GABA mechanisms.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Lipid Metabolism; Organ Size; Picrotoxin; Rats; Rats, Inbred Strains; Sleep; Valproic Acid; Vasotocin | 1986 |
Oxidation of [U-14C]succinic semialdehyde in cultured human lymphoblasts: measurement of residual succinic semialdehyde dehydrogenase activity in 11 patients with 4-hydroxybutyric aciduria.
Topics: Aldehyde Oxidoreductases; Carbon Dioxide; Cells, Cultured; Child; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Infant; Kinetics; Lactates; Lactic Acid; Lymphocytes; Male; Malonates; Oxidation-Reduction; Sodium Oxybate; Succinate-Semialdehyde Dehydrogenase; Succinates; Succinic Acid; Valproic Acid | 1988 |
Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Carbamazepine; Child; Epilepsies, Partial; Evoked Potentials, Auditory; Female; gamma-Aminobutyric Acid; Humans; Long-Term Care; Male; Middle Aged; Phenobarbital; Reaction Time; Valproic Acid | 1988 |
Effect of sodium valproate (VPA) on cerebral amino acids: mechanism of gamma-aminobutyric acid (GABA) elevation and possible causal relation of VPA-induced encephalopathy and glutamine level.
Topics: Amino Acids; Animals; Brain Chemistry; Brain Diseases; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Mice, Inbred Strains; Valproic Acid | 1988 |
Comparison of the biological activity of sodium valproate and L-lysine valproate on brain GABA levels by (3H) muscimol radioreceptor assay.
Topics: Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Lysine; Male; Mice; Muscimol; Radioligand Assay; Rats; Rats, Inbred Strains; Valproic Acid | 1988 |
Suppression of preoptic GABA release caused by push-pull-perfusion with sodium valproate.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Motor Activity; Perfusion; Preoptic Area; Rats; Time Factors; Valproic Acid | 1988 |
Chronic valproic acid therapy and synaptic markers of amino acid neurotransmission.
Topics: Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Male; Rats; Valproic Acid | 1985 |
In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Nerve Endings; Rats; Rats, Inbred Strains; Synaptosomes; Valproic Acid | 1985 |
[GABAergic control of hypophyseal gonadotropic function and prolactin. Demonstration by valproic acid].
Topics: Adult; Aged; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropins, Pituitary; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Middle Aged; Prolactin; Stimulation, Chemical; Valproic Acid | 1985 |
Effect of valproate on brain GABA: comparison with various medium chain fatty acids.
Topics: Ammonia; Animals; Anticonvulsants; Brain Chemistry; Fatty Acids; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Valproic Acid | 1985 |
Improved method for isolating synaptosomes from 11 regions of one rat brain: electron microscopic and biochemical characterization and use in the study of drug effects on nerve terminal gamma-aminobutyric acid in vivo.
Topics: 3-Mercaptopropionic Acid; Acetylcholinesterase; Animals; Brain; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glycerolphosphate Dehydrogenase; Microscopy, Electron; Nerve Endings; Rats; Rats, Inbred Strains; Succinate Dehydrogenase; Synaptosomes; Valproic Acid | 1985 |
Evidence for a GABAergic control of the exercise-induced rise in GH in man.
Topics: Adult; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Physical Exertion; Time Factors; Valproic Acid | 1985 |
In vivo effects of anticonvulsant drugs on nerve terminal (synaptosomal) GABA levels in 11 brain regions of the rat.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Nerve Endings; Rats; Rats, Inbred Strains; Synaptosomes; Valproic Acid | 1985 |
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1985 |
[A clinico-biochemical study of acute encephalopathy in patients treated with Ca-hopantenate].
Topics: Acute Disease; Adolescent; Adult; Age Factors; Blood Chemical Analysis; Brain Diseases; Child; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Infant; Male; Pantothenic Acid; Reye Syndrome; Valproic Acid | 1985 |
GABAergic, dopaminergic and cholinergic interactions in perphenazine-induced catatonia in rats.
Topics: Animals; Bromocriptine; Catatonia; Dopamine; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Muscimol; Parasympatholytics; Perphenazine; Piracetam; Rats; Rats, Inbred Strains; Scopolamine; Time Factors; Valproic Acid | 1985 |
Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission; Synaptosomes; Valproic Acid | 1984 |
Protective effects of diazepam and valproate on beta-vinyllactic acid-induced seizures.
Topics: Animals; Brain; Convulsants; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Lactates; Male; Mice; Seizures; Synaptic Transmission; Valproic Acid | 1984 |
Evidence that GABA mechanisms mediate the anxiolytic action of benzodiazepines: a study with valproic acid.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Discrimination Learning; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Valproic Acid | 1980 |
Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide, and sulthiame in the rat.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Ethosuximide; gamma-Aminobutyric Acid; Glutamates; Male; Neurotransmitter Agents; Organ Specificity; Phenobarbital; Phenytoin; Rats; Taurine; Thiazines; Valproic Acid | 1981 |
Differential effects of gamma-aminobutyric acid (GABA)-elevating agents on the neuroleptic-induced activation of striatal tyrosine-hydroxylase: evidence that di-n-propylacetate augments GABAergic neurotransmission.
Topics: Aminooxyacetic Acid; Animals; Antipsychotic Agents; Corpus Striatum; Drug Interactions; gamma-Aminobutyric Acid; Male; Rats; Substantia Nigra; Synaptic Transmission; Tyrosine 3-Monooxygenase; Valproic Acid | 1981 |
[Role of the GABA-ergic link in the development of the tranquilizing effect in cats].
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Brain Chemistry; Cats; Diazepam; gamma-Aminobutyric Acid; Male; Valproic Acid | 1981 |
Effect of treatment with sodium valproate and diazepam on plasma corticotropin in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Depression, Chemical; Diazepam; Female; gamma-Aminobutyric Acid; Humans; Hypothalamus; Male; Middle Aged; Nelson Syndrome; Pituitary Neoplasms; Valproic Acid | 1981 |
The presynaptic effects of valproic acid in the isolated frog spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Electric Conductivity; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Potassium; Rana pipiens; Spinal Cord; Synapses; Valproic Acid | 1981 |
New anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Humans; Valproic Acid | 1980 |
Enhancement of GABAergic inhibition: a mechanism of action of benzodiazepines, phenobarbital, valproate and L-cycloserine in the cat spinal cord.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cats; Cycloserine; GABA Antagonists; gamma-Aminobutyric Acid; Interneurons; Motor Neurons; Phenobarbital; Spinal Cord; Valproic Acid | 1982 |
A new patient with 4-hydroxybutyric aciduria, a possible defect of 4-aminobutyrate metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Male; Sodium Oxybate; Valproic Acid | 1983 |
Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid.
Topics: Amino Acids; Aminooxyacetic Acid; Animals; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrazines; Isoniazid; Male; Mice; Pyridoxal Phosphate; Pyridoxine; Synaptosomes; Valproic Acid | 1984 |
GABA-opiates interactions in the activity of analgesics.
Topics: Aminooxyacetic Acid; Analgesics, Opioid; Animals; Bicuculline; Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Male; Morphine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Structure-Activity Relationship; Valproic Acid | 1983 |
Effects of a GABA-mimetic drug (sodium valproate) on visually evoked potentials in chronic schizophrenics.
Topics: Adult; Brain; Brief Psychiatric Rating Scale; Chronic Disease; Clozapine; Dibenzazepines; Drug Therapy, Combination; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Humans; Middle Aged; Schizophrenia; Valproic Acid | 1984 |
Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children.
Topics: Animals; Brain; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Valproic Acid | 1984 |
Clinical and experimental studies on the role of GABA in the regulation of ACTH secretion: a review.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Cushing Syndrome; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Hypothalamus, Middle; Nelson Syndrome; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1984 |
Determination of gamma-aminobutyric and glutamic acids in rat brain by liquid chromatography with electrochemical detection.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Electrochemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Rats; Substantia Nigra; Valproic Acid | 1984 |
The role of GABA in the anticonflict action of sodium valproate and chlordiazepoxide.
Topics: Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conflict, Psychological; Drug Interactions; gamma-Aminobutyric Acid; Ion Channels; Male; Muscimol; Rats; Receptors, GABA-A; Synaptic Transmission; Valproic Acid | 1984 |
Suppression by sodium valproate of gamma-vinyl GABA-induced facilitation of visual evoked potentials in rats.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Male; Neuroglia; Rats; Rats, Inbred Strains; Transaminases; Valproic Acid; Vigabatrin | 1981 |
[Absence of effects of sodium valproate on the estrous cycle of the rat].
Topics: Animals; Estrus; Female; gamma-Aminobutyric Acid; Pregnancy; Rats; Rats, Inbred Strains; Valproic Acid | 1982 |
[Sleep in chronic chorea patients after therapy with sodium valproate].
Topics: Adult; Chorea; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; Middle Aged; Motor Activity; Sleep; Sleep Stages; Valproic Acid | 1984 |
Effects of anticonvulsants on excitability and GABA sensitivity of cat dorsal root ganglion cells.
Topics: Action Potentials; Animals; Anticonvulsants; Cats; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Kinetics; Male; Phenobarbital; Receptors, Cell Surface; Receptors, GABA-A; Valproic Acid | 1981 |
Pharmacologic analysis of sodium valproate-induced suppression of secondary components of visual evoked potentials in albino rats.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Interactions; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Male; Naloxone; Pentylenetetrazole; Photic Stimulation; Picrotoxin; Rats; Synaptic Transmission; Time Factors; Valproic Acid | 1981 |
Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Evoked Potentials, Visual; Female; Flumazenil; gamma-Aminobutyric Acid; Immobilization; Kinetics; Male; Rats; Receptors, Drug; Receptors, GABA-A; Valproic Acid | 1982 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Pressure; Seizures; Synaptic Transmission; Tremor; Valproic Acid | 1982 |
Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice.
Topics: Animals; Conflict, Psychological; Diazepam; Exploratory Behavior; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nitrazepam; Rats; Rats, Inbred Strains; Synaptic Transmission; Urethane; Valproic Acid | 1982 |
Sodium valproate enhances responses to GABA receptor activation only at high concentrations.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Medulla Oblongata; Muscimol; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution; Valproic Acid | 1982 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrome; Pituitary Neoplasms; Serotonin; Valproic Acid | 1983 |
The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression.
Topics: Amygdala; Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Membrane Potentials; Muscimol; Neural Inhibition; Neural Pathways; Rats; Synaptic Transmission; Valproic Acid | 1983 |
Valproic acid: update on its mechanisms of action.
Topics: Brain; Drug Synergism; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials; Synapses; Synaptic Transmission; Valproic Acid | 1984 |
Valproic acid and metabolites: pharmacological and toxicological studies.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Rodentia; Synaptic Transmission; Valproic Acid | 1984 |
Valproate: recent findings and perspectives.
Topics: Chemical Phenomena; Chemistry; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials; Synapses; Valproic Acid | 1984 |
Effects of tetanus toxin after intracerebral microinjection are antagonized by drugs enhancing GABAergic transmission in adult fowls.
Topics: Animals; Behavior, Animal; Chickens; Ethanolamines; gamma-Aminobutyric Acid; Injections, Intraventricular; Microinjections; Synaptic Transmission; Tetanus Toxin; Valproic Acid | 1984 |
GABA-ergic drugs: effects on conditioning, memory and learning.
Topics: Aminooxyacetic Acid; Animals; Conditioning, Operant; gamma-Aminobutyric Acid; Learning; Male; Memory; Motor Activity; Pantothenic Acid; Piracetam; Rats; Rats, Inbred Strains; Valproic Acid | 1983 |
Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Mice; Mice, Inbred DBA; Seizures; Structure-Activity Relationship; Valproic Acid | 1983 |
Regular and lasting neocortical spiking produced by systemic administration of a steroid derivative in the rat.
Topics: Action Potentials; Androstanes; Animals; Azasteroids; Behavior, Animal; Cerebral Cortex; Diazepam; Electroencephalography; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Humans; Rats; Rats, Inbred Strains; Stereotyped Behavior; Steroids, Heterocyclic; Valproic Acid | 1983 |
Effects of n-di-propylacetate on aggressive behavior and brain GABA level in isolated mice.
Topics: Aggression; Animals; Brain; gamma-Aminobutyric Acid; Humans; Kinetics; Male; Mice; Mice, Inbred DBA; Organ Specificity; Social Isolation; Valproic Acid | 1983 |
Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; intracerebroventricular studies in mice.
Topics: Animals; Apomorphine; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Picrotoxin; Quinolines; Stereoisomerism; Structure-Activity Relationship; Valproic Acid | 1983 |
A dual action of valproic acid upon morphine analgesia and morphine withdrawal.
Topics: Analgesia; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Humans; Mice; Morphine; Naloxone; Substance Withdrawal Syndrome; Valproic Acid | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid | 1983 |
Concentrations of gamma-aminobutyric acid and adenosine in the CSF in progressive myoclonus epilepsy without Lafora's bodies.
Topics: Adenosine; Adolescent; Adult; Clonazepam; Epilepsies, Myoclonic; Female; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Valproic Acid | 1983 |
Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system.
Topics: Acetamides; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Substantia Nigra; Valproic Acid | 1983 |
Pharmacological activation of gamma-aminobutyric acid-system blunts prolactin response to mechanical breast stimulation in puerperal women.
Topics: Adult; Breast; Female; gamma-Aminobutyric Acid; Humans; Physical Stimulation; Postpartum Period; Pregnancy; Prolactin; Random Allocation; Valproic Acid | 1984 |
Quasi-morphine withdrawal behaviour: indication for a specific involvement of the GABA-ergic nerve terminal compartment.
Topics: Animals; gamma-Aminobutyric Acid; Humans; Male; Morphine; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Valproic Acid | 1983 |
Inhibition by sodium valproate of the transport of GABA through the Deiters' neurone plasma membrane.
Topics: Animals; Biological Transport, Active; Cell Membrane; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Neurons; Rabbits; Valproic Acid; Vestibular Nuclei; Vestibular Nucleus, Lateral | 1984 |
Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats.
Topics: Aminooxyacetic Acid; Analgesics; Animals; Body Temperature; Brain Chemistry; Female; gamma-Aminobutyric Acid; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1984 |
Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose-dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Valproic Acid | 1984 |
Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Oxidoreductases; Phenobarbital; Phenytoin; Valproic Acid | 1984 |
[Effect of gamma-aminobutyric and gamma-hydroxybutyric acids on the arousal of susliks from hibernation].
Topics: Aminooxyacetic Acid; Animals; gamma-Aminobutyric Acid; Hibernation; Hydroxybutyrates; Male; Sciuridae; Semicarbazides; Sodium Oxybate; Valproic Acid | 1984 |
Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood Pressure; Brain; Desoxycorticosterone; Ethanolamines; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Heart Rate; Hemodynamics; Hypertension; Male; Muscimol; Nephrectomy; Phenylephrine; Rats; Rats, Inbred Strains; Valproic Acid | 1984 |
Disposition of progabide and valproic acid following intraperitoneal administration in rhesus monkey.
Topics: Absorption; Administration, Oral; Animals; Biological Availability; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intravenous; Kinetics; Macaca mulatta; Male; Peritoneum; Valproic Acid | 1984 |
Lead-induced convulsions in young infants--a case history and the role of GABA and sodium valproate in the pathogenesis and treatment.
Topics: Chemical Phenomena; Chemistry; Citric Acid Cycle; gamma-Aminobutyric Acid; Humans; Infant; Lead; Lead Poisoning; Male; Seizures; Valproic Acid | 1984 |
Gabaergic modulation of mouse-killing in the rat.
Topics: Aggression; Aminocaproates; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Strychnine; Valproic Acid | 1984 |
Sydenham's chorea treated with sodium valproate.
Topics: Adolescent; Brain Chemistry; Chorea; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid | 1984 |
[Mechanism of action of an anticonvulsant, sodium dipropylacetate].
Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Male; Rats; Valproic Acid | 1981 |
[Influence of the GABAergic system on eating behavior induced by the tail pinching technic in rats].
Topics: Animals; Energy Intake; Feeding Behavior; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains; Stress, Psychological; Valproic Acid | 1981 |
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Brain; Cell Compartmentation; Electroshock; gamma-Aminobutyric Acid; Nerve Endings; Rats; Seizures; Substantia Nigra; Time Factors; Transaminases; Valproic Acid; Vigabatrin | 1980 |
Studies on the involvement of GABA in the aggression directed by groups of intact or gonadectomized male and female mice towards lactating intruders.
Topics: Aggression; Animals; Brain Chemistry; Castration; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Humans; Lactation; Male; Mice; Pregnancy; Valproic Acid | 1980 |
Effects of some gamma-aminobutyric acid (GABA)-ergic drugs on the dopaminergic control of human growth hormone secretion.
Topics: Adult; Apomorphine; Baclofen; Diazepam; Dopamine; gamma-Aminobutyric Acid; Growth Hormone; Humans; Levodopa; Male; Valproic Acid | 1980 |
Valproic acid.
Topics: gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Humans; Valproic Acid | 1980 |
Sodium di-n-propylacetate (valproate) potentiates responses to GABA and muscimol on single central neurones.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Medulla Oblongata; Muscimol; Neurons; Oxazoles; Rats; Reticular Formation; Valproic Acid | 1980 |
[Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration].
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Dihydroxyphenylalanine; Disulfiram; Dopamine; gamma-Aminobutyric Acid; Humans; Male; Methyldopa; Rats; Semicarbazides; Substance Withdrawal Syndrome; Valproic Acid | 1980 |
Increase in striatal acetylcholine levels by GABAergic agents: dependence on corticostriatal neurons.
Topics: Acetylcholine; Animals; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Muscimol; Neurons; Rats; Valproic Acid | 1980 |
Increase of human plasma GABA by sodium valproate.
Topics: Adult; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid | 1980 |
Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; gamma-Aminobutyric Acid; Humans; Male; Mice; Motor Activity; Muscimol; Nipecotic Acids; Oxazoles; Social Isolation; Time Factors; Valproic Acid | 1980 |
Di-n-propylacetate-induced abstinence behaviour as a possible correlate of increased GABA-ergic activity in the rat.
Topics: 3-Mercaptopropionic Acid; Aminooxyacetic Acid; Animals; Behavior, Animal; Catalepsy; gamma-Aminobutyric Acid; Humans; Male; Picrotoxin; Rats; Strychnine; Substance Withdrawal Syndrome; Thiosemicarbazones; Valproic Acid | 1980 |
On a possible role of GABA in mania. Therapeutic efficacy of sodium valproate.
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Double-Blind Method; Drug Evaluation; gamma-Aminobutyric Acid; Humans; Valproic Acid | 1981 |
The effect of sodium-n-dipropyl acetate on gamma-aminobutyric acid-dependent inhibition in the rat cortex and substantia nigra in relation to its anticonvulsant activity.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Muscimol; Neurons; Rats; Substantia Nigra; Time Factors; Valproic Acid | 1980 |
Intractable seizures: review and guide for clinical usage of valproic acid.
Topics: Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; Seizures; Valproic Acid | 1981 |
Studies on gamma-aminobutyric acid transport in cobalt experimental epilepsy in the rat.
Topics: Animals; Biological Transport; Brain; Cobalt; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Rats; Seizures; Synaptosomes; Valproic Acid | 1981 |
A comparative study of the pharmacology of inhibitors of GABA-metabolism.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Anticonvulsants; Electroshock; Ethanolamines; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Seizures; Valproic Acid | 1980 |
Effects of branched-chain fatty acids on GABA-degradation and behavior: further evidence for a role of GABA in quasi-morphine abstinence behavior.
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Brain Chemistry; Caproates; Dose-Response Relationship, Drug; Fatty Acids; gamma-Aminobutyric Acid; Humans; Male; Morphine Dependence; Pentanoic Acids; Rats; Rats, Inbred Strains; Valproic Acid | 1980 |
Sodium valproate enhancement of gamma-aminobutyric acid (GABA) inhibition: electrophysiological evidence for anticonvulsant activity.
Topics: Action Potentials; Animals; Anticonvulsants; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Neural Inhibition; Rats; Valproic Acid | 1981 |
Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Muscimol; Picrotoxin; Stimulation, Chemical; Valproic Acid | 1981 |
Plasma GABA levels in neurological patients under treatment with valproic acid.
Topics: Adult; Aged; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Time Factors; Valproic Acid | 1981 |
[New evidence for a GABA-ergic component in the mechanism of action of benzodiazepine tranquilizers].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Bicuculline; Central Nervous System; Drug Interactions; gamma-Aminobutyric Acid; Male; Rabbits; Semicarbazides; Valproic Acid | 1981 |
Effect of sodium valproate on hypothalamic neurons in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Hypothalamus; Male; Neural Inhibition; Neurons; Rats; Valproic Acid | 1981 |
A dual role for GABA in quasi-morphine abstinence behavior induced by di-n-propylacetate involving both initiation and termination.
Topics: Animals; Behavior, Animal; Drug Tolerance; gamma-Aminobutyric Acid; Humans; Hydroxylation; Male; Morphine Dependence; Rats; Substance Withdrawal Syndrome; Valproic Acid | 1981 |
Valproate induced changes in GABA metabolism at the subcellular level.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Male; Mice; Synaptosomes; Valproic Acid | 1981 |
Effect of di-N-propylacetic acid (valproic acid) on the TSH response to TRH--a presumptive role for gamma aminobutyric acid.
Topics: 4-Aminobutyrate Transaminase; Adult; Female; gamma-Aminobutyric Acid; Humans; Hypothyroidism; Male; Middle Aged; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Valproic Acid | 1981 |
Sodium valproate exerts anti-conflict activity in rats without any concomitant rise in forebrain GABA level.
Topics: Aminocaproates; Aminooxyacetic Acid; Animals; Behavior, Animal; Brain; Conflict, Psychological; Dose-Response Relationship, Drug; Electroshock; gamma-Aminobutyric Acid; Lorazepam; Male; Rats; Valproic Acid; Vigabatrin | 1981 |
A proposed mechanism for the anticonvulsant action of valproate.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Fatty Acids; gamma-Aminobutyric Acid; Glycogen; Ketone Bodies; Kinetics; Mice; Models, Biological; Seizures; Valproic Acid | 1981 |
Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Nerve Endings; Synaptosomes; Valproic Acid | 1981 |
The effects of the gabaergic drug, sodium valproate, on prolactin secretion in normal and hyperprolactinemic subjects.
Topics: Adenoma; Adult; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Kinetics; Male; Middle Aged; Pituitary Neoplasms; Prolactin; Valproic Acid | 1982 |
Interactions of di-n-propylacetate, gabaculine, and aminooxyacetic acid: anticonvulsant activity and the gamma-aminobutyrate system.
Topics: Acetates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Kinetics; Mice; Valproic Acid | 1981 |
Transport of GABA at the blood-CSF interface.
Topics: Animals; Dogs; Female; gamma-Aminobutyric Acid; Injections, Intravenous; Kinetics; Male; Valproic Acid | 1982 |
Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Electroshock; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kinetics; Male; Mice; Valproic Acid | 1982 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1982 |
Modulatory role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin secretion in patients with chronic renal failure.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Kidney Failure, Chronic; Luteinizing Hormone; Male; Middle Aged; Progesterone; Renal Dialysis; Testosterone; Valproic Acid | 1982 |
Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Mice, Inbred Strains; Transaminases; Valproic Acid | 1982 |
A presumptive role for gamma-aminobutyric acid in the regulation of gonadotropin secretion in man.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Humans; Luteinizing Hormone; Menstruation; Progesterone; Radioimmunoassay; Valproic Acid | 1982 |
Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Time Factors; Valproic Acid | 1982 |
Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Binding Sites; Cats; Cyclohexanecarboxylic Acids; Dogs; Ethanolamines; Female; gamma-Aminobutyric Acid; Hemodynamics; Male; Rats; Rats, Inbred Strains; Species Specificity; Transaminases; Valproic Acid; Vigabatrin | 1982 |
The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice.
Topics: Animals; Behavior, Animal; Brain Chemistry; Ethanolamines; Female; gamma-Aminobutyric Acid; Mice; Rats; Rats, Inbred Strains; Valproic Acid | 1982 |
Evidence that a GABAergic mechanism influences the development of DOCA-salt hypertension in the rat.
Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; gamma-Aminobutyric Acid; Hypertension; Male; Nephrectomy; Phenylephrine; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1982 |
GABAergic influences on defensive fighting in rats.
Topics: Aggression; Aminocaproates; Animals; Baclofen; Bicuculline; Electroshock; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin | 1982 |
Sodium valproate: kinetic profile and effects on GABA levels in various brain areas of the rat.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Kinetics; Male; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 1982 |
[Effect of GABA-ergic substances on humoral immunity].
Topics: Animals; Antibody Formation; gamma-Aminobutyric Acid; Immunization; Immunosuppressive Agents; Mice; Mice, Inbred CBA; Sodium Oxybate; Spleen; Valproic Acid | 1982 |
Interrelations between dopaminergic and GABA-ergic transmitter mechanisms in apomorphine stereotypy.
Topics: Aminooxyacetic Acid; Animals; Apomorphine; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Humans; Levodopa; Male; Picrotoxin; Rats; Stereotyped Behavior; Valproic Acid | 1982 |
Anticonvulsant activation of pain-suppressive systems.
Topics: Aldehyde Oxidoreductases; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Male; Neural Inhibition; Nociceptors; Periaqueductal Gray; Phenytoin; Rats; Rats, Inbred Strains; Succinate-Semialdehyde Dehydrogenase; Valproic Acid | 1982 |
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Ionophores; Magnesium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1995 |
Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine.
Topics: Animals; Anticonvulsants; Dogs; Female; gamma-Aminobutyric Acid; Glycine; Injections, Intravenous; Male; Time Factors; Valproic Acid | 1995 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substantia Nigra; Valproic Acid; Vigabatrin | 1995 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphins; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Peptide Fragments; Phenobarbital; Phenytoin; Seizures; Sodium Channels; Synaptic Transmission; Valproic Acid | 1994 |
Rapid assay for gamma-aminobutyric acid in mouse brain synaptosomes using gas chromatography-mass spectrometry.
Topics: Acetamides; Animals; Brain; Brain Chemistry; Fluoroacetates; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamate Decarboxylase; Indicators and Reagents; Mice; Neurons; Synaptosomes; Trimethylsilyl Compounds; Valproic Acid | 1994 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid | 1994 |
Inhibition of neonatal brain fuel utilization by valproate and E-delta 2-valproate is not a consequence of the stimulation of the gamma-aminobutyric acid shunt.
Topics: Animals; Animals, Newborn; Brain; Energy Metabolism; Fatty Acids, Monounsaturated; gamma-Aminobutyric Acid; Lactates; Lactic Acid; Rats; Rats, Wistar; Valproic Acid | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; Humans; Male; Netherlands; Phenobarbital; Phenytoin; Primidone; Quality of Health Care; Statistics, Nonparametric; Treatment Outcome; Valproic Acid; Vigabatrin | 1994 |
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Topics: Alkynes; Amino Acids; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Rats; Rats, Wistar; Valproic Acid; Vigabatrin | 1994 |
Utilization of aspirin, quinine and verapamil in the prevention and treatment of scorpion venom intoxication.
Topics: Animals; Aspirin; Female; gamma-Aminobutyric Acid; Lethal Dose 50; Mice; Mice, Inbred C57BL; Poisoning; Quinine; Scorpion Venoms; Valproic Acid; Verapamil | 1993 |
Role of GABA and opioids in the regulation of the vasopressin response to physical exercise in normal men.
Topics: Adult; Arginine Vasopressin; Cardiovascular Physiological Phenomena; Endorphins; Exercise; gamma-Aminobutyric Acid; Humans; Male; Naloxone; Respiration; Valproic Acid | 1993 |
Effects of GABAergic drugs on ethanol-induced gastric lesions.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Ethanol; GABA Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Hemorrhage; Indomethacin; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Valproic Acid | 1993 |
Influence of sodium valproate on medium-late luteal phase pulsatile LH secretion in normal women.
Topics: Adult; Estradiol; Female; gamma-Aminobutyric Acid; Humans; Luteal Phase; Luteinizing Hormone; Progesterone; Secretory Rate; Valproic Acid | 1994 |
Evidence of stimulation of the gamma-aminobutyric acid shunt by valproate and E-delta 2-valproate in neonatal rat brain.
Topics: Animals; Animals, Newborn; Brain; Fatty Acids, Monounsaturated; gamma-Aminobutyric Acid; Glucose; In Vitro Techniques; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Valproic Acid | 1993 |
Gamma-aminobutyric acid mediation of the inhibitory effect of endogenous opioids on the arginine vasopressin and oxytocin responses to nicotine from cigarette smoking.
Topics: Adult; Analysis of Variance; Arginine Vasopressin; Drug Interactions; Endorphins; gamma-Aminobutyric Acid; Humans; Male; Naloxone; Nicotine; Oxytocin; Smoking; Valproic Acid | 1993 |
Comparative effects of valproate and the new experimental anticonvulsant drug alpha-ethyl-alpha-methyl-thiobutyrolactone on selected metabolite levels in the plasma, livers, and brains of infant mice.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Amino Acids; Animals; Animals, Suckling; Anticonvulsants; Blood Glucose; Brain Chemistry; Carnitine; Coenzyme A; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Hydroxybutyrates; Liver; Mice; Valproic Acid | 1996 |
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Ireland; Neurology; Pediatrics; Pituitary Hormones; Prednisone; Pyridoxine; Spasms, Infantile; Surveys and Questionnaires; United Kingdom; Valproic Acid; Vigabatrin; Workforce | 1996 |
Examining the role of vigabatrin.
Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Complex Partial; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid; Vigabatrin | 1996 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overdose; Ethanol; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Seizures; Suicide, Attempted; Valproic Acid | 1996 |
Amphetamine and vigabatrin down regulate aromatic L-amino acid decarboxylase mRNA levels.
Topics: Amphetamine; Animals; Anticonvulsants; Aromatic-L-Amino-Acid Decarboxylases; Base Sequence; Brain; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Male; Molecular Sequence Data; Oligonucleotide Probes; Organ Specificity; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription, Genetic; Valproic Acid; Vigabatrin | 1996 |
Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Phenytoin; Rats; Seizures; Valproic Acid | 1995 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; gamma-Aminobutyric Acid; Lithium Chloride; Male; Neuroprotective Agents; Pentobarbital; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Valproic Acid | 1996 |
Effects of valproate-induced alteration of the GABAergic system on pulsatile luteinizing hormone secretion in ovariectomized women.
Topics: Adult; Female; gamma-Aminobutyric Acid; Humans; Luteinizing Hormone; Middle Aged; Ovariectomy; Pulsatile Flow; Valproic Acid | 1996 |
Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning.
Topics: Acetates; Adult; Amines; Anticonvulsants; Biomarkers; Blood Chemical Analysis; Chromatography, Thin Layer; Coma; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Hemoperfusion; Humans; Hypotension; Intensive Care Units; Male; Renal Dialysis; Shock; Valproic Acid | 1996 |
Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia.
Topics: Adult; Arginine Vasopressin; Blood Glucose; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Humans; Hypoglycemia; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxytocin; Valproic Acid | 1996 |
Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Depression, Chemical; Drug Evaluation, Preclinical; Electric Stimulation; Electroencephalography; Enzyme Inhibitors; Epilepsy; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Neural Inhibition; Phenobarbital; Rats; Valproic Acid | 1996 |
Interactions between dopamine and GABA in the control of ambulatory activity.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Wistar; Valproic Acid | 1996 |
The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Male; N-Methylaspartate; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Valproic Acid | 1997 |
Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.
Topics: Animals; Anticonvulsants; Baclofen; Binding, Competitive; Brain Chemistry; Ethosuximide; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Organophosphorus Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-B; Sodium Oxybate; Valproic Acid | 1997 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; Disease Susceptibility; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Homovanillic Acid; Hydroxyindoleacetic Acid; Mesencephalon; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Species Specificity; Tyrosine 3-Monooxygenase; Valproic Acid | 1996 |
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
Topics: 4-Aminobutyrate Transaminase; Animals; Binding Sites; Brain; Enzyme Inhibitors; Ethosuximide; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; In Vitro Techniques; Male; Rats; Rats, Wistar; Sodium Oxybate; Valproic Acid | 1997 |
Time course of alpha-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal gamma-aminobutyric acid levels in comparison to valproic acid.
Topics: Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Solubility; Synaptosomes; Valproic Acid | 1997 |
[West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment].
Topics: Anticonvulsants; Atrophy; Cerebral Palsy; Cerebral Ventricles; Child; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Leukomalacia, Periventricular; Magnetic Resonance Imaging; Male; Retrospective Studies; Spasms, Infantile; Tomography, X-Ray Computed; Valproic Acid; Vigabatrin | 1997 |
Dissimilar effects of lithium and valproic acid on GABA and glutamine concentrations in rat cerebrospinal fluid.
Topics: Animals; Antimanic Agents; Female; gamma-Aminobutyric Acid; Glutamine; Hyponatremia; Lithium Chloride; Rats; Rats, Wistar; Valproic Acid | 1998 |
Studies of drugs in epilepsy cited by author are not evidence based.
Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Evidence-Based Medicine; GABA Agents; gamma-Aminobutyric Acid; Humans; Randomized Controlled Trials as Topic; Valproic Acid; Vigabatrin | 1998 |
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Picrotoxin; Rats; Rats, Sprague-Dawley; Tiagabine; Valproic Acid | 1997 |
Electrophysiologic evaluation of a patient with peripheral visual field contraction associated with vigabatrin.
Topics: Adolescent; Anticonvulsants; Electroretinography; Epilepsies, Partial; gamma-Aminobutyric Acid; Humans; Male; Retina; Valproic Acid; Vigabatrin; Vision Disorders; Visual Fields | 1998 |
[Partial complex status epilepticus: diagnostic difficulties].
Topics: Anticonvulsants; Child; Crime; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalography; Epilepsy, Complex Partial; gamma-Aminobutyric Acid; Humans; Male; Mood Disorders; Status Epilepticus; Stress Disorders, Post-Traumatic; Stress, Psychological; Valproic Acid; Vigabatrin | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Maleate; Drug Evaluation, Preclinical; Electric Stimulation; Electroshock; Epilepsies, Partial; gamma-Aminobutyric Acid; Kindling, Neurologic; Levetiracetam; Male; Mice; Piracetam; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Retina; Seizures; Sensitivity and Specificity; Time Factors; Valproic Acid; Vigabatrin | 1998 |
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biogenic Amines; Blood Platelets; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Dopamine; Dopamine Uptake Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium; Male; Norepinephrine; p-Chloroamphetamine; Phenytoin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Syndrome; Synaptosomes; Tetrodotoxin; Triazines; Valproic Acid; Zonisamide | 1998 |
Alcoholism abolishes the gamma-aminobutyric acid (GABA)ergic control of GH secretion in humans.
Topics: Adult; Alcoholism; Baclofen; GABA Agents; GABA Agonists; gamma-Aminobutyric Acid; Human Growth Hormone; Humans; Kinetics; Male; Middle Aged; Valproic Acid | 1998 |
[Drug-resistant epilepsy].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Resistance; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glioma; Humans; Magnetic Resonance Imaging; Neoplasms, Germ Cell and Embryonal; Neoplasms, Neuroepithelial; Phenytoin; Temporal Lobe; Tomography, Emission-Computed, Single-Photon; Valproic Acid; Vigabatrin | 1998 |
Outer retinal dysfunction in patients treated with vigabatrin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Electrooculography; Electroretinography; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Prospective Studies; Retinal Diseases; Time Factors; Valproic Acid; Vigabatrin; Visual Acuity; Visual Fields | 1999 |
A case of fever following antiepileptic treatment.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epilepsy, Complex Partial; Female; Fever of Unknown Origin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Oxcarbazepine; Triazines; Valproic Acid; Vigabatrin | 1999 |
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersensitivity; Drug Interactions; Epilepsy, Complex Partial; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Phenytoin; Valproic Acid | 1999 |
Mood stabilizer combinations for bipolar disorder.
Topics: Acetates; Adolescent; Age Factors; Amines; Antimanic Agents; Bipolar Disorder; Child; Cyclohexanecarboxylic Acids; Drug Eruptions; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Triazines; Valproic Acid | 1999 |
Inhibition of uptake, steady-state currents, and transient charge movements generated by the neuronal GABA transporter by various anticonvulsant drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Binding Sites; Biological Transport; Carrier Proteins; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electric Conductivity; Female; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mice; Nipecotic Acids; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; Tiagabine; Valproic Acid; Vigabatrin; Xenopus laevis | 1999 |
A case of sustained massive gabapentin overdose without serious side effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Drug Overdose; Epilepsies, Partial; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Renal Insufficiency; Time Factors; Tremor; Valproic Acid | 1999 |
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamazepine; Entorhinal Cortex; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Male; Pentobarbital; Phenobarbital; Phenytoin; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 2000 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Erectile Dysfunction; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Middle Aged; Phenobarbital; Phenytoin; Sexual Dysfunctions, Psychological; Triazines; Valproic Acid | 2000 |
Changes in use of valproate and other mood stabilizers for patients with schizophrenia from 1994 to 1998.
Topics: Acetates; Adult; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Utilization; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium Carbonate; Male; Middle Aged; New York; Retrospective Studies; Schizophrenia; Schizophrenic Psychology; Valproic Acid | 2000 |
GABA levels within the medial preoptic area: effects of chronic administration of sodium valproic acid.
Topics: Animals; Chromatography, High Pressure Liquid; Estrus; Female; GABA Agents; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Preoptic Area; Valproic Acid | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, Neurologic; Male; Muscimol; Rats; Rats, Wistar; Seizures; Thiourea; Valproic Acid | 2000 |
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Topics: Adult; Anticonvulsants; Astrocytes; Carrier Proteins; Cells, Cultured; Female; Fetus; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Nipecotic Acids; Organic Anion Transporters; Pregnancy; Pregnancy Trimester, Second; Temporal Lobe; Tiagabine; Valproic Acid; Vigabatrin | 1999 |
Divalproex sodium increases plasma GABA levels in healthy volunteers.
Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid | 2000 |
Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis.
Topics: Amino Acid Transport System X-AG; Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Carrier Proteins; Epilepsy; Ferrous Compounds; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Valproic Acid | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Neurotransmitter Agents; Pentylenetetrazole; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2000 |
Cortical hyperexcitability is cortical under-inhibition: evidence from a novel functional test of migraine patients.
Topics: Adult; Aged; Analgesics; Cortical Spreading Depression; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Methysergide; Middle Aged; Migraine Disorders; Migraine with Aura; Perceptual Masking; Photic Stimulation; Pizotyline; Propranolol; Valproic Acid; Visual Cortex | 2000 |
Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy.
Topics: 4-Aminopyridine; Acetates; Amines; Analgesics; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Humans; Membrane Potentials; Migraine Disorders; Nipecotic Acids; Pyramidal Cells; Tiagabine; Time Factors; Valproic Acid; Vigabatrin | 2000 |
Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Inbred DBA; Neurons; Preoptic Area; Seizures; Valproic Acid | 2000 |
Valproate prevents epileptiform activity after trauma in an in vitro model in neocortical slices.
Topics: Animals; Anticonvulsants; Brain Injuries; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Neocortex; Neural Inhibition; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Synaptic Transmission; Valproic Acid | 2000 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids; Dizziness; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fructose; Gabapentin; gamma-Aminobutyric Acid; Heart Defects, Congenital; Humans; Lamotrigine; Nausea; Obesity; Stevens-Johnson Syndrome; Topiramate; Triazines; Valproic Acid | 2000 |
Different control of GH secretion by gamma-amino- and gamma-hydroxy-butyric acid in 4-year abstinent alcoholics.
Topics: Adult; Alcoholism; Baclofen; Biomarkers; GABA Agents; GABA Agonists; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hydroxybutyrates; Male; Statistics, Nonparametric; Temperance; Valproic Acid | 2001 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid | 2000 |
Benzodiazepines and anticonvulsants for social phobia (social anxiety disorder).
Topics: Acetates; Alprazolam; Amines; Anticonvulsants; Benzodiazepines; Clinical Trials as Topic; Clonazepam; Cyclohexanecarboxylic Acids; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Phobic Disorders; Placebos; Pregabalin; Treatment Outcome; Valproic Acid | 2001 |
Evaluating the tolerability of the newer mood stabilizers.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Central Nervous System Diseases; Cyclohexanecarboxylic Acids; Drug Information Services; Fructose; Gabapentin; gamma-Aminobutyric Acid; Gastrointestinal Diseases; Humans; Incidence; Lamotrigine; Mental Disorders; Neurotoxicity Syndromes; Topiramate; Triazines; Valproic Acid | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
The acute effect of valproate on cerebral energy metabolism in mice.
Topics: Acetates; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Brain; Citric Acid Cycle; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Phosphocreatine; Valproic Acid | 2001 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Levetiracetam; Male; Microinjections; Phenobarbital; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Blood Platelets; Case-Control Studies; Dose-Response Relationship, Drug; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Myoclonic Epilepsy, Juvenile; Triazines; Valproic Acid | 2003 |
Identification and quantitation of xenobiotics by 1H NMR spectroscopy in poisoning cases.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Ethylene Glycols; Forensic Medicine; Formates; Furans; gamma-Aminobutyric Acid; Hemostatics; Herbicides; Humans; Magnetic Resonance Spectroscopy; Methanol; Paraquat; Pesticides; Salicylates; Solvents; Valproic Acid; Xenobiotics | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
Gabapentin in geriatric mania.
Topics: Acetates; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Valproic Acid | 2003 |
Effects of chronic lithium and sodium valproate on concentrations of brain amino acids.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Lithium; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Taurine; Valproic Acid | 2003 |
Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Valproic Acid; Zolpidem | 2003 |
Valproate and GABAergic system effects.
Topics: Brain; gamma-Aminobutyric Acid; Humans; Schizophrenia; Valproic Acid | 2003 |
Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.
Topics: Animals; Anticonvulsants; Carbon; Convulsants; Dimerization; Drug Design; Electroshock; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Subcutaneous; Isonipecotic Acids; Ligands; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Prodrugs; Seizures; Valproic Acid; Vigabatrin | 2003 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2003 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techniques; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Models, Biological; Nipecotic Acids; Organic Cation Transport Proteins; Phenytoin; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Proteins; Solute Carrier Family 22 Member 5; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 2004 |
Valproic acid induces manifestations of simultaneous dopamine enhancement and reduction in schizophrenia.
Topics: Adult; Benztropine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agents; gamma-Aminobutyric Acid; Haloperidol; Humans; Muscarinic Antagonists; Schizophrenia; Time Factors; Valproic Acid | 2004 |
The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells.
Topics: Animals; Astrocytes; bcl-Associated Death Protein; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Cell Count; Cell Differentiation; Cells, Cultured; Cyclin D2; Cyclins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Interleukin-6; Leukemia Inhibitory Factor; Lithium Chloride; Neurons; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Time Factors; Trans-Activators; Tretinoin; Tubulin; Valproic Acid | 2004 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug Hypersensitivity; Ethosuximide; Fever; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lymphatic Diseases; Phenobarbital; Phenytoin; Syndrome; Triazines; Valproic Acid | 2004 |
Relations between substrate affinities and charge equilibration rates in the rat GABA cotransporter GAT1.
Topics: Animals; DNA, Complementary; Electrophysiology; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Potentials; Membrane Transport Proteins; Nipecotic Acids; Patch-Clamp Techniques; Point Mutation; Rats; Recombinant Proteins; RNA, Messenger; Sodium; Solutions; Valproic Acid; Xenopus laevis | 2005 |
Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Neural Inhibition; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Substantia Nigra; Synaptic Transmission; Valproic Acid | 2004 |
Valproic acid inhibits corticotropin-releasing factor synthesis and release from the rat hypothalamus in vitro: evidence for the involvement of GABAergic neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; Male; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Secretory Rate; Synaptic Transmission; Tissue Culture Techniques; Valproic Acid | 2004 |
Beneficial interaction between vigabatrin and valproate against seizures induced by pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Pentylenetetrazole; Valproic Acid; Vigabatrin | 2005 |
Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report.
Topics: Aged; Aggression; Alzheimer Disease; Amines; Antipsychotic Agents; Benzodiazepines; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Gabapentin; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Goserelin; Humans; Male; Olanzapine; Propranolol; Quetiapine Fumarate; Risperidone; Testosterone; Trazodone; Treatment Outcome; Valproic Acid | 2005 |
Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Middle Aged; Phenytoin; Pregabalin; Triazines; Valproic Acid | 2005 |
Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex.
Topics: Action Potentials; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Prefrontal Cortex; Quisqualic Acid; Rats; Rats, Wistar; Salts; Sodium; Synapses; Valproic Acid | 2006 |
Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Benzodiazepines; Carbamazepine; Cross Reactions; Cyclohexanecarboxylic Acids; Doxepin; Drug Hypersensitivity; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Molecular Structure; Phenytoin; Skin Tests; Syndrome; Valproic Acid | 2006 |
New device to control combined lingual and palatal myoclonus.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Eye Movements; Gabapentin; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Myoclonus; Technology, Dental; Tongue; Valproic Acid | 2007 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus; GABA Agents; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Rats; Seizures; Valproic Acid; Vigabatrin | 2007 |
Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Basal Ganglia; Conditioning, Classical; Disease Models, Animal; Dopamine; Emotions; Enkephalins; Female; gamma-Aminobutyric Acid; Gene Expression; Learning; Male; Maze Learning; Memory; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Wistar; Recognition, Psychology; RNA, Messenger; Valproic Acid | 2007 |
Visual field defect during therapy with valproic-acid.
Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration; Time; Transaminases; Urea; Valproic Acid; Vision Disorders; Visual Fields | 2007 |
Divalproex, lithium and suicide among Medicaid patients with bipolar disorder.
Topics: Adult; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Emergency Services, Psychiatric; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lithium Compounds; Male; Medicaid; Oregon; Proportional Hazards Models; Psychotropic Drugs; Risk Factors; Suicide; Suicide Prevention; Suicide, Attempted; United States; Valproic Acid | 2008 |
Valproic acid alters GnRH-GABA interactions in cycling female rats.
Topics: Animals; Estrous Cycle; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Neural Cell Adhesion Molecule L1; Neurons; Ovary; Rats; Rats, Wistar; Sialic Acids; Valproic Acid | 2007 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, Health; Cohort Studies; Cyclohexanecarboxylic Acids; Drug Prescriptions; Drug Utilization; Epilepsy; Family Practice; Female; Gabapentin; gamma-Aminobutyric Acid; Geography; Humans; Italy; Longitudinal Studies; Male; Middle Aged; Mood Disorders; Pain; Pharmacoepidemiology; Phenobarbital; Practice Patterns, Physicians'; Prevalence; Valproic Acid | 2007 |
[Use of anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Seizures; Treatment Outcome; Valproic Acid; Young Adult | 2008 |
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.
Topics: Animals; Antipsychotic Agents; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly; Cytosine; DNA Methylation; Drug Synergism; Drug Therapy, Combination; Epigenesis, Genetic; Extracellular Matrix Proteins; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamate Decarboxylase; Histone Deacetylase Inhibitors; Histones; Humans; Nerve Tissue Proteins; Neurons; Nicotinic Agonists; Receptors, Nicotinic; Reelin Protein; Repressor Proteins; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2009 |
Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Choline O-Acetyltransferase; Disease Models, Animal; Excitatory Amino Acid Agonists; Functional Laterality; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Ibotenic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Valproic Acid | 2009 |
Effects of sodium valproate on synaptic transmission and neuronal excitability in rat hippocampus.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Polyunsaturated Alkamides; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Synaptic Transmission; Valproic Acid | 2009 |
GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus.
Topics: Amines; Animals; Anticonvulsants; Cerebral Arteries; Cyclohexanecarboxylic Acids; Disease Models, Animal; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Migraine Disorders; Neural Inhibition; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Sensory Receptor Cells; Synaptic Transmission; Trigeminal Nerve; Valproic Acid; Ventral Thalamic Nuclei | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Glutathione; Lipid Peroxidation; Magnesium; Male; Nitric Oxide; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Seizures; Statistics, Nonparametric; Valproic Acid | 2010 |
Modular glass chip system measuring the electric activity and adhesion of neuronal cells--application and drug testing with sodium valproic acid.
Topics: Animals; Cell Adhesion; Cell Proliferation; Drug Evaluation, Preclinical; Electricity; gamma-Aminobutyric Acid; Glass; Glutamate Decarboxylase; Materials Testing; Mice; Microelectrodes; Neurons; Valproic Acid | 2010 |
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.
Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Double-Blind Method; Fructose; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Randomized Controlled Trials as Topic; Topiramate; Valproic Acid | 2010 |
Effects of valproate on neurotransmission associated with ryanodine receptors.
Topics: Animals; Antimanic Agents; Blotting, Western; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Valproic Acid | 2010 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; China; Clonazepam; Cyclohexanecarboxylic Acids; Exanthema; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Male; Medicine, Chinese Traditional; Middle Aged; Phenobarbital; Phenytoin; Piracetam; Retrospective Studies; Topiramate; Triazines; Valproic Acid; Young Adult | 2010 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Neurons; Pentylenetetrazole; Valproic Acid | 2011 |
Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Drug Combinations; Gabapentin; gamma-Aminobutyric Acid; Male; Methionine Sulfoximine; Mice; Piperidines; Seizures; Valproic Acid | 2010 |
Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes.
Topics: Adolescent; Adult; Aged; Amines; Animals; Anticonvulsants; Calcium; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Female; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Male; Middle Aged; Neocortex; Nipecotic Acids; Oximes; Phenytoin; Piracetam; Potassium; Pregabalin; Rats; Rats, Wistar; Synaptosomes; Tetanus Toxin; Tetrodotoxin; Triazines; Valproic Acid; Veratridine; Young Adult | 2011 |
Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.
Topics: Aldehyde Dehydrogenase 1 Family; Amino Acids; Animals; Animals, Newborn; Calbindin 2; Calbindins; Cell Movement; Cerebral Cortex; Dopamine Antagonists; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Food, Formulated; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Hydroxamic Acids; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Organ Culture Techniques; Parvalbumins; Pregnancy; Retinal Dehydrogenase; Retinol-Binding Proteins; S100 Calcium Binding Protein G; Salicylamides; Signal Transduction; Telencephalon; Tretinoin; Valproic Acid; Vitamin A | 2011 |
Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pain Measurement; Phenytoin; Retrospective Studies; Sri Lanka; Treatment Outcome; Trigeminal Neuralgia; Valproic Acid | 2012 |
Combination of valproate and paroxetine in mice exposed to picrotoxin.
Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus Accumbens; Paroxetine; Picrotoxin; Seizures; Selective Serotonin Reuptake Inhibitors; Thiobarbituric Acid Reactive Substances; Valproic Acid | 2012 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Medicine, African Traditional; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Phytotherapy; Plant Extracts; Plant Leaves; Psychotic Disorders; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Valproic Acid | 2012 |
Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue.
Topics: Animals; Cysteine; Dithiothreitol; Ethylmaleimide; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Humans; Kinetics; Mesylates; Mutation; Oocytes; Patch-Clamp Techniques; Rhodamines; Sodium Chloride; Sulfhydryl Reagents; Transfection; Valproic Acid; Xenopus laevis | 2012 |
Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.
Topics: Animals; Antipsychotic Agents; Baclofen; Behavior, Animal; Bicuculline; Carbamazepine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Lamotrigine; Lithium Carbonate; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscimol; Obsessive-Compulsive Disorder; Receptors, GABA-A; Triazines; Valproic Acid | 2013 |
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Drug Therapy, Combination; Epilepsy; Female; Fructose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Phenobarbital; Pilot Projects; Piracetam; Pregabalin; Quality of Life; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Young Adult | 2012 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Male; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid; Zebrafish | 2013 |
Antiepileptic drugs (AEDs) during pregnancy and risk of congenital jaw and oral malformation.
Topics: Abnormalities, Drug-Induced; Adverse Drug Reaction Reporting Systems; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Data Mining; Datasets as Topic; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Jaw Abnormalities; Lamotrigine; Mouth Abnormalities; Pregnancy; Risk Factors; Topiramate; Triazines; Valproic Acid | 2013 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electric Stimulation; Fructose; Gabapentin; gamma-Aminobutyric Acid; Lamotrigine; Magnesium Sulfate; Mice; Rats; Seizures; Topiramate; Triazines; Valproic Acid | 2012 |
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries; Carbamazepine; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Disease Progression; Early Diagnosis; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Italy; Male; Middle Aged; Personality Disorders; Quetiapine Fumarate; Time Factors; Topiramate; Treatment Outcome; Valproic Acid | 2013 |
[Therapeuetic aspects of cluster headache in the practical clinical site].
Topics: Adult; Amines; Amitriptyline; Cluster Headache; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Subcutaneous; Male; Middle Aged; Self Care; Sumatriptan; Valproic Acid; Young Adult | 2013 |
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coculture Techniques; Connexin 43; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Gap Junctions; Inflammation; Microglia; Neuroglia; Phenytoin; Rats; Rats, Wistar; Transforming Growth Factor beta1; Valproic Acid | 2014 |
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.
Topics: Animals; Autistic Disorder; Behavior, Animal; Bumetanide; Chlorides; Cytoprotection; Disease Models, Animal; Female; Fragile X Mental Retardation Protein; gamma-Aminobutyric Acid; Maternal-Fetal Exchange; Mice; Oxytocin; Parturition; Pregnancy; Rats; Valproic Acid | 2014 |
Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study.
Topics: Animals; Area Under Curve; Brain Chemistry; Drug Evaluation, Preclinical; Food-Drug Interactions; gamma-Aminobutyric Acid; Glucuronosyltransferase; Glycine max; Isoenzymes; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Valproic Acid | 2014 |
Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Axons; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Histone Deacetylase Inhibitors; Neurons; Rats; Synapses; Time Factors; Valproic Acid; Vesicular Inhibitory Amino Acid Transport Proteins | 2014 |
Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care.
Topics: Acetamides; Amines; Cyclohexanecarboxylic Acids; Dried Blood Spot Testing; Fluoroacetates; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trimethylsilyl Compounds; Valproic Acid | 2014 |
Transient hypothyroidism induced by anticonvulsant agents.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hypothyroidism; Thyroxine; Trigeminal Neuralgia; Valproic Acid | 2014 |
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Electromyography; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sleep; Sleep Wake Disorders; Sleep, REM; Uterus; Valproic Acid; Wakefulness | 2014 |
Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases.
Topics: Amines; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Drug Monitoring; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Limit of Detection; Nipecotic Acids; Oxcarbazepine; Phenytoin; Piracetam; Pregabalin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tiagabine; Topiramate; Triazines; Valproic Acid | 2014 |
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival Diseases; Hirsutism; Humans; Levetiracetam; Male; Middle Aged; Phenytoin; Piracetam; Pregabalin; Risk Factors; Sex Factors; Valproic Acid; Weight Gain | 2015 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Databases, Factual; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Male; Middle Aged; Oxcarbazepine; Pharmacovigilance; Phenobarbital; Spain; Stevens-Johnson Syndrome; Triazines; Valproic Acid; Young Adult | 2015 |
Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid.
Topics: 4-Aminobutyrate Transaminase; Anticonvulsants; Binding Sites; Computer Simulation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Humans; Hydrogen Bonding; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ligands; Molecular Docking Simulation; Structural Homology, Protein; Succinate-Semialdehyde Dehydrogenase; Valproic Acid | 2016 |
Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism.
Topics: Amygdala; Animals; Anxiety; Autism Spectrum Disorder; Cerebellum; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Rats; Rats, Wistar; RNA, Messenger; Valproic Acid | 2016 |
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Hospitalization; Humans; Lamotrigine; Male; Medication Adherence; Middle Aged; Oxcarbazepine; Phenytoin; Proportional Hazards Models; Retrospective Studies; Risk Factors; Taiwan; Topiramate; Triazines; Valproic Acid; Young Adult | 2016 |
Using a graphical risk tool to examine willingness to take migraine prophylactic medications.
Topics: Amines; Analgesics; Antidepressive Agents; Antihypertensive Agents; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Longitudinal Studies; Male; Migraine Disorders; Pain Measurement; Pre-Exposure Prophylaxis; Propranolol; Retrospective Studies; Surveys and Questionnaires; Valproic Acid; Venlafaxine Hydrochloride | 2016 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Inflammation; Male; Mice; Neuralgia; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Valproic Acid | 2017 |
The transcription factor Npas4 contributes to adolescent development of prefrontal inhibitory circuits, and to cognitive and emotional functions: Implications for neuropsychiatric disorders.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognition; Emotions; Female; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Male; Mental Disorders; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neural Pathways; Parvalbumins; Prefrontal Cortex; RNA, Messenger; Sex Characteristics; Sexual Maturation; Valproic Acid | 2017 |
Antiepileptic drugs: Impacts on human serum paraoxonase-1.
Topics: Amines; Anticonvulsants; Aryldialkylphosphatase; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Kinetics; Levetiracetam; Phenytoin; Piracetam; Primidone; Turkey; Valproic Acid | 2017 |
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Neurotransmitter Agents; Phenylalanine; Psychomotor Agitation; Seizures; Serotonin; Valproic Acid | 2017 |
Reduced protein expressions of cytomembrane GABA
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; K Cl- Cotransporters; Male; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solute Carrier Family 12, Member 2; Symporters; Valproic Acid | 2017 |
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Databases, Factual; Diplopia; Dizziness; Epilepsy, Temporal Lobe; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Humans; Lamotrigine; Lethargy; Male; Middle Aged; Oxcarbazepine; Pregabalin; Retrospective Studies; Sclerosis; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Vertigo; Vigabatrin; Vision Disorders; Young Adult | 2017 |
Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Autistic Disorder; Cerebellar Diseases; Cerebellum; Disease Models, Animal; gamma-Aminobutyric Acid; Interleukin-6; Laser Therapy; Male; Oxidative Stress; Rats; Valproic Acid | 2017 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Pregabalin; Seizures; Valproic Acid | 2018 |
Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Graft Survival; Histone Deacetylases; Humans; Injections, Intraperitoneal; Male; Necrosis; Rats; Rats, Sprague-Dawley; Signal Transduction; Skin; Surgical Flaps; Valproic Acid; Wound Healing | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizures; Time Factors; Valproic Acid; Vigabatrin | 2020 |
Valproic acid induces nuclear factor erythroid 2-related factor 2 expression in fetal and neonatal brains but not in adult brain: evidence of the gamma-aminobutyric acid-shift hypothesis.
Topics: Age Factors; Animals; Brain; Female; GABA Agents; gamma-Aminobutyric Acid; Mice; NF-E2-Related Factor 2; Oxidative Stress; Pregnancy; Valproic Acid | 2020 |
Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test.
Topics: Animals; Autistic Disorder; Cerebellum; Cerebral Cortex; Female; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamic Acid; Hippocampus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Valproic Acid; Vesicular Glutamate Transport Protein 1 | 2020 |
Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Female; GABA-A Receptor Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Synaptic Potentials; Synaptic Transmission; Valproic Acid | 2021 |
Contribution of rare genetic variants to drug response in absence epilepsy.
Topics: Anticonvulsants; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; Humans; Pharmaceutical Preparations; Valproic Acid | 2021 |
Anxiolytic and memory enhancing potential of aloe vera and flax seed oil in rats: A comparative study with valproic acid.
Topics: Aloe; Animals; Anti-Anxiety Agents; gamma-Aminobutyric Acid; Linseed Oil; Memory; Rats; Rats, Wistar; Valproic Acid | 2020 |
Postweaning positive modulation of α5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Calcium; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA-A; Social Behavior; Valproic Acid | 2022 |
Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Humans; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid | 2022 |
Generational synaptic functions of GABA
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Male; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 2022 |
Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Male; Prenatal Exposure Delayed Effects; Rats; Social Behavior; Valproic Acid | 2022 |
Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner.
Topics: Animals; Behavior, Animal; Chlorpyrifos; Corn Oil; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred C57BL; Pesticides; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors; Social Behavior; Valproic Acid | 2022 |
Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA
Topics: Epilepsy; gamma-Aminobutyric Acid; Humans; Midazolam; Receptors, GABA-A; Valproic Acid | 2022 |
A simple and easy non-derivatization gas chromatography-mass spectrometry method for simultaneous quantification of valproic acid, gabapentin, pregabalin, and vigabatrin in human plasma.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Pregabalin; Valproic Acid; Vigabatrin | 2023 |
The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Erythropoietin; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Symporters; Valproic Acid | 2023 |
Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Autistic Disorder; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Homeostasis; Male; Memantine; Pregnancy; Rats; Rats, Wistar; Valproic Acid | 2023 |