valproic acid and folic acid

valproic acid has been researched along with folic acid in 113 studies

Research

Studies (113)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (9.73)	18.7374
1990's	11 (9.73)	18.2507
2000's	38 (33.63)	29.6817
2010's	40 (35.40)	24.3611
2020's	13 (11.50)	2.80

Authors

Authors	Studies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Elmazar, MM; Nau, H	1
Nau, H; Wegner, C	2
Carson, R; Haust, HL; Peter, F; Poon, HC; VanDeWetering, C	1
Carl, GF	1
Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H	1
Hosokawa, K; Kugoh, T	1
Anfosso, R; Calò, M; De Sarro, GB; Marmo, E; Nisticò, G; Rotiroti, D	1
Bentsen, KD; Gram, L; Veje, A	1
Dam, M; Gram, L; Hendel, J; Winkel, P	1
Butlin, AT; Cook, ML; Danta, G	1
Richens, A	1
Carl, GF; Smith, DB	1
Bentsen, KD; Flachs, H; Gram, L; Parnas, J	1
Hunt, G; Oakeshott, P	1
Nau, H	1
Dial, SL; Gehring, TA; Grafton, TF; Hansen, DK; Siitonen, PH	1
Eguchi, T; Fujita, N; Kishi, T; Ueda, K	1
Hishida, R; Nau, H	1
Achón, M; Alonso-Aperte, E; Pérez-Miguelsanz, J; Ubeda, N; Varela-Moreiras, G	1
Fiehn, W; Kohl, B; Rieser, PA; Ringleb, P; Schwaninger, M; Walter-Sack, I; Winter, R	1
Craig, J; Morrison, P; Morrow, J; Patterson, V	1
Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE	1
Barber, RC; Bennett, GD; Eberwine, JH; Finnell, RH; Gelineau-van Waes, J; Lammer, EJ; Piedrahita, JA; Shaw, GM; Wlodarczyk, B	1
Artuch, R; Cardo, E; Colomé, C; Farré, C; Monrós, E; Pineda, M; Valls, C; Vilaseca, MA	1
Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P	1
Cummings, AD; Hackes, B; Hunt, A; Ryan, C; Sanford, MG	1
Crawford, P	1
Alonso-Aperte, E; Ubeda, N; Varela-Moreiras, G	1
Caksen, H; Geda, G; Içağasioğlu, D	1
Karabiber, H; Otlu, B; Ozerol, E; Sonmezgoz, E; Yakinci, C; Yologlu, S	1
Hiilesmaa, V; Kaaja, E; Kaaja, R	1
Padmanabhan, R; Shafiullah, MM	1
Yerby, MS	1
Finnell, RH; Merriweather, MY; Spiegelstein, O; Wicker, NJ	1
Gilmour-White, SK; O'Brien, MD	1
Gidal, BE; Hammer, A; Tamura, T; Vuong, A	1
Dawson, JE; Raymond, AM; Winn, LM	1
Kafantaris, V; Saito, E; Tsivkin, R	1
Coker, I; Karaguzel, O; Ozdamar, O; Sener, U; Topbas, M; Zorlu, Y	1
Akkus, M; Baran, OP; Kervancioglu, P; Nergiz, Y	1
Baran, O; Nergiz, Y; Tuncer, MC	1
Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A	1
Benedict, S; Nagelkerke, N; Padmanabhan, R; Shafiullah, M	1
Keown, P; McAllister-Williams, H; Young, A	1
Attilakos, A; Garoufi, A; Katsarou, E; Mastroyianni, S; Papakonstantinou, E; Schulpis, K; Voudris, K	1
Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E	1
Brown, JF; Cezar, GG; Gage, FH; Muotri, AR; Piekarczyk, MS; Quam, JA; Rosa, GJ; Smith, AM	1
Kurul, S; Unalp, A; Yiş, U	1
Akin, R; Demirkaya, E; Gokçay, E; Gul, D; Kul, M; Unay, B; Vurucu, S	1
Gupta, S; Kruger, WD; Leclerc, D; Roy, M; Rozen, R; Wu, Q	1
Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE	1
Kluger, BM; Meador, KJ	1
Harden, CL; Sethi, NK	1
Belcastro, V; Striano, P	1
Asadi, S; Behzadi, AH; Chalian, M; Ghadiri, M; Omrani, Z	1
Ornoy, A	1
Bek, S; Cakir, E; Gökçil, Z; Odabaşi, Z; Oz, O	1
Bakker, MK; de Jong-van den Berg, LT; Jentink, J; Nijenhuis, CM; Wilffert, B	1
Aydogdu, SD; Colak, O; Dinleyici, EC; Ozdemir, O; Yakut, A; Yarar, C	1
Hsieh, CL; Peng, CC; Peng, RY; Tsai, WJ; Wang, HE	1
Chan, SH; Chang, CC; Chang, WN; Chen, SD; Chuang, HY; Chuang, YC; Huang, CR; Lin, TK; Lu, CH; Tan, TY	1
Bursali, A; Duransoy, YK; Kara, B; Selcuki, M; Umur, AS; Umur, N; Vatansever, HS	1
Blom, H; Frisch, C; Linnebank, M; Semmler, A; Smith, D	1
Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D	1
Bochanova, EN; Dmitrenko, DV; Piliugina, MS; Shapovalova, EA; Snaĭder, NA; Sychev, DA	1
Karlov, VA; Kozhokaru, AB; Serkina, AV; Zhidkova, IA	1
Alexander, JM; Wilson, KL	1
Baek, JH; Bernstein, EE; Nierenberg, AA	1
Chen, KC; Ding, CY; Hsieh, CL; Peng, CC; Tsai, WJ; Wu, JF	1
Keenan, N; Sadlier, LG; Wiltshire, E	1
Baxter, P	1
Fathe, K; Finnell, RH; Palacios, A	1
Chu, SL; Ho, YL; Huang, PT; Liou, HH; Tsai, HJ; Yu, WH	1
Chen, Y; Chen, Z; Fang, Z; Huang, M; Li, H; Ni, G; Qin, J; Zhou, J; Zhou, L; Zhou, Y	1
Sharma, TK; Sitaraman, S; Vardey, SK	1
Bennett, K; Doherty, CP; Murphy, S	1
Gotlib, D; Kurlander, J; Muzik, M; Perelstein, E; Riba, M; Zivin, K	1
Akimova, D; Chen, Q; Finnell, RH; Gross, SS; Lin, Y; Ross, ME; Wlodarczyk, BJ	1
Bigler, L; Bleul, C; Blom, H; Frisch, C; Linnebank, M; Prost, JC; Semmler, A; Smith, D	1
Ali, EN; El Sadik, AO; Emam, HY; Rizk, AA; Shona, SI	1
Frieauff, E; Rehn, M; Stüber, T; Wiedemann, K	1
Baldessarini, RJ; Patel, N; Viguera, AC	1
Furugen, A; Iseki, K; Kobayashi, M; Kurosawa, Y; Narumi, K; Nishimura, A	1
Gao, T; Gu, J; Guo, X; Li, D; Li, J; Li, K	1
Ali, N; Nazish, H; Shakir, S	1
Koren, G; Ornoy, A; Yanai, J	1
de Caestecker, L; Doi, L; Frank, JW; Sher, J	1
Eum, J; Hwang, BJ; Kee, Y; Ki, S; Kim, KN; Kwon, SH; Raslan, AA	1
Aboregela, AM; Eid, KA; Gouda, RHE; Ibrahim, IH	1
Cakin, H; Kazan, S; Ozak, A; Turgut, U	1
Oakley, GP	1
A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV	1
Green, R; Reynolds, EH	1
Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE	1
Eyal, S; Moushaev, S; Shmuel, M; Tetro, N	1
Cheng, Q; Di, Y; Fan, J; Kang, M; Lan, J; Li, J; Li, Z; Ren, W; Tian, Y; Wei, C; Zhai, C; Zheng, Q	1
Bondesson, M; Garyfalidis, E; Gustafsson, JÅ; Kondamadugu, VS; Muhsen, M; Riu, A; Youngs, J	1
Furugen, A; Iseki, K; Jinno, N; Kanno, Y; Kobayashi, M; Kurosawa, Y; Narumi, K; Ohyama, N	1
Bien, CG; Hagemann, A; Knaak, N; Müffelmann, B	1
Aronu, AE; Bisi-Onyemaechi, AI; Chikani, UN; Ojinnaka, NC; Uwaezuoke, NA	1
Błaszczyk, B; Czuczwar, SJ; Miziak, B; Pluta, R	1
Meador, KJ	1
Biliaminu, SA; N Adeboye, MA; Ojuawo, A; Omefe, PN	1

Reviews

18 review(s) available for valproic acid and folic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Controlled trials in epilepsy: a review. Epilepsia, 1982, Volume: 23, Issue:5 Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Epilepsy; Folic Acid; Humans; Hydantoins; Psychotropic Drugs; Random Allocation; Research Design; Valproic Acid; Vitamin D	1982
Valproic acid-induced neural tube defects. Ciba Foundation symposium, 1994, Volume: 181 Topics: Animals; Embryo, Mammalian; Folic Acid; Humans; Neural Tube Defects; Species Specificity; Structure-Activity Relationship; Teratogens; Valproic Acid	1994
Epilepsy and pregnancy. Seizure, 2002, Volume: 11 Suppl A Topics: Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fetal Diseases; Folic Acid; Humans; Pregnancy; Pregnancy Complications; Prenatal Care; Valproic Acid; Vitamin K	2002
Management issues for women with epilepsy: neural tube defects and folic acid supplementation. Neurology, 2003, Sep-01, Volume: 61, Issue:6 Suppl 2 Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Pregnancy Complications; Spinal Dysraphism; Valproic Acid	2003
Management of epilepsy in women. Postgraduate medical journal, 2005, Volume: 81, Issue:955 Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilities; Epilepsy; Female; Fetal Diseases; Folic Acid; Humans; Hyperemesis Gravidarum; Infertility, Female; Intrauterine Devices; Pregnancy; Pregnancy Complications; Progestins; Puerperal Disorders; Valproic Acid; Vitamin K Deficiency	2005
Recent advances on neural tube defects with special reference to Valproic Acid. Endocrine, metabolic & immune disorders drug targets, 2006, Volume: 6, Issue:1 Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Deficiency; Free Radical Scavengers; Humans; Neural Tube Defects; Pregnancy; Reperfusion Injury; Teratogens; Valproic Acid	2006
Identification of small molecules from human embryonic stem cells using metabolomics. Stem cells and development, 2007, Volume: 16, Issue:6 Topics: Biomarkers; Cell Culture Techniques; Cell Differentiation; DNA Primers; Embryonic Stem Cells; Folic Acid; Glutamic Acid; Humans; Kynurenine; Metabolism; Pyrrolidonecarboxylic Acid; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid	2007
Teratogenicity of antiepileptic medications. Seminars in neurology, 2008, Volume: 28, Issue:3 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Risk Assessment; Risk Factors; Valproic Acid	2008
Epileptic disorders in pregnancy: an overview. Current opinion in obstetrics & gynecology, 2008, Volume: 20, Issue:6 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhage; Humans; Lamotrigine; Obstetrics; Pregnancy; Pregnancy Complications; Risk; Seizures; Triazines; Valproic Acid	2008
Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 28, Issue:1 Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Anticonvulsants; Autistic Disorder; Child; Child Development; Child, Preschool; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Fetus; Folic Acid; Humans; Infant; Maternal-Fetal Exchange; Milk, Human; Nervous System Diseases; Neural Tube Defects; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Semen; Syndrome; Teratogens; Valproic Acid	2009
Seizures and intracranial hemorrhage. Obstetrics and gynecology clinics of North America, 2013, Volume: 40, Issue:1 Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; Heparin; Humans; Infant, Newborn; Intracranial Hemorrhages; Lamotrigine; Monitoring, Physiologic; North America; Phenobarbital; Phenytoin; Pregnancy; Risk Factors; Seizures; Subarachnoid Hemorrhage; Triazines; Valproic Acid; Vitamin K	2013
One-carbon metabolism and bipolar disorder. The Australian and New Zealand journal of psychiatry, 2013, Volume: 47, Issue:11 Topics: Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Brain; Folic Acid; Humans; Lamotrigine; Methylenetetrahydrofolate Reductase (NADPH2); Triazines; Valproic Acid	2013
Guideline adherence for mentally ill reproductive-aged women on treatment with valproic acid: a retrospective chart review. The Journal of clinical psychiatry, 2016, Volume: 77, Issue:4 Topics: Abnormalities, Drug-Induced; Contraception Behavior; Female; Folic Acid; Guideline Adherence; Humans; Infant, Newborn; Mental Disorders; Neural Tube Defects; Neurocognitive Disorders; Patient Compliance; Pregnancy; Pregnancy Complications; Valproic Acid	2016
Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human. Reproductive toxicology (Elmsford, N.Y.), 2018, Volume: 80 Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Diabetes, Gestational; Ethanol; Ethyl Ethers; Female; Folic Acid; Folic Acid Antagonists; Humans; Oxidative Stress; Pregnancy; Pregnancy in Diabetics; Prenatal Exposure Delayed Effects; Sulfhydryl Compounds; Teratogens; Valproic Acid	2018
Valproate and folate: Congenital and developmental risks. Epilepsy & behavior : E&B, 2020, Volume: 108 Topics: Anticonvulsants; Brain; Female; Folic Acid; Humans; Nervous System Malformations; Neural Tube Defects; Neurodevelopmental Disorders; Pregnancy; Valproic Acid; Vitamin B Complex	2020
Epilepsy in Pregnancy-Management Principles and Focus on Valproate. International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Epilepsy; Female; Folic Acid; Histone Deacetylase Inhibitors; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Valproic Acid	2022
Effects of Maternal Use of Antiseizure Medications on Child Development. Neurologic clinics, 2022, Volume: 40, Issue:4 Topics: Anticonvulsants; Child; Child Development; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Pregnancy Complications; Valproic Acid	2022

Trials

3 trial(s) available for valproic acid and folic acid

Article	Year
Controlled trials in epilepsy: a review. Epilepsia, 1982, Volume: 23, Issue:5 Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Epilepsy; Folic Acid; Humans; Hydantoins; Psychotropic Drugs; Random Allocation; Research Design; Valproic Acid; Vitamin D	1982
Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial. Acta psychiatrica Scandinavica, 2009, Volume: 120, Issue:6 Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adult; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Drug Administration Schedule; Folic Acid; Humans; Placebos; Severity of Illness Index; Treatment Outcome; Valproic Acid	2009
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. Seizure, 2012, Volume: 21, Issue:4 Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Valproic Acid; Vitamin B 12; Vitamin B Complex; Young Adult	2012

Other Studies

93 other study(ies) available for valproic acid and folic acid

Article	Year
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. Teratogenesis, carcinogenesis, and mutagenesis, 1992, Volume: 12, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Encephalocele; Female; Folic Acid; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Valproic Acid	1992
Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis. Neurology, 1992, Volume: 42, Issue:4 Suppl 5 Topics: Animals; Circadian Rhythm; Fatty Acids, Monounsaturated; Female; Fetus; Folic Acid; Leucovorin; Mice; Neural Tube Defects; Pregnancy; Valproic Acid	1992
Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent. Reproductive toxicology (Elmsford, N.Y.), 1991, Volume: 5, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Decidua; Embryo, Mammalian; Female; Fetal Resorption; Folic Acid; Leucovorin; Mice; Mice, Inbred Strains; Neural Tube Defects; Pregnancy; Valproic Acid	1991
Protoporphyrinaemia and decreased activities of 5-aminolevulinic acid dehydrase and uroporphyrinogen I synthetase in erythrocytes of a Vitamin B6-deficient epileptic boy given valproic acid and carbamazepine. Clinical biochemistry, 1989, Volume: 22, Issue:3 Topics: Ammonia-Lyases; Carbamazepine; Chromatography, Ion Exchange; Epilepsy; Erythrocytes; Folic Acid; Humans; Hydroxymethylbilane Synthase; Infant; Lead; Longitudinal Studies; Male; Porphobilinogen Synthase; Porphyrins; Protoporphyrins; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Valproic Acid; Vitamin B 6 Deficiency	1989
Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat. Neurochemical research, 1986, Volume: 11, Issue:5 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Carbon; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Valproic Acid	1986
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. The Quarterly journal of medicine, 1987, Volume: 65, Issue:247 Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenytoin; Valproic Acid	1987
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy. Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:3 Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorders; Phenobarbital; Phenytoin; Primidone; Valproic Acid; Vitamin B 12	1983
Convulsant effects of kainic acid and dihydrofolate are antagonized by sodium valproate. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1983, Volume: 4, Issue:3 Topics: Animals; Convulsants; Folic Acid; Folic Acid Antagonists; Kainic Acid; Pyrrolidines; Rats; Rats, Inbred Strains; Valproic Acid	1983
Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study. Acta neurologica Scandinavica, 1983, Volume: 67, Issue:4 Topics: Adolescent; Adult; Aged; Carbamazepine; Epilepsy; Folic Acid; Humans; Middle Aged; Thyroid Hormones; Valproic Acid	1983
The effects of carbamazepine and valproate on folate metabolism in man. Acta neurologica Scandinavica, 1984, Volume: 69, Issue:4 Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Female; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Intestinal Absorption; Intestines; Liver; Male; Middle Aged; Pteroylpolyglutamic Acids; Time Factors; Valproic Acid	1984
Anticonvulsants, folic acid and memory dysfunction in epileptics. Clinical and experimental neurology, 1984, Volume: 20 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memory Disorders; Middle Aged; Phenytoin; Valproic Acid	1984
Pharmacokinetics of anticonvulsant drugs. Acta neurologica Scandinavica. Supplementum, 1980, Volume: 80 Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epilepsy; Folic Acid; Humans; Kinetics; Phenobarbital; Phenytoin; Protein Binding; Tissue Distribution; Valproic Acid	1980
Interactions between folates and carbamazepine or valproate in the rat. Neurology, 1982, Volume: 32, Issue:9 Topics: Animals; Brain; Carbamazepine; Drug Interactions; Flurothyl; Folic Acid; Leucovorin; Male; Rats; Rats, Inbred Strains; Seizures; Valproic Acid	1982
Prevention of neural tube defects. Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889 Topics: Abnormalities, Drug-Induced; Carbamazepine; Female; Folic Acid; Humans; Neural Tube Defects; Pregnancy; Spinal Dysraphism; Valproic Acid	1994
Effect of supplemental folic acid on valproic acid-induced embryotoxicity and tissue zinc levels in vivo. Teratology, 1995, Volume: 52, Issue:5 Topics: Animals; Anticonvulsants; Circadian Rhythm; Drug Interactions; Embryo, Mammalian; Embryonic and Fetal Development; Female; Folic Acid; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Pregnancy; Rats; Tissue Distribution; Valproic Acid; Zinc	1995
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. Journal of the neurological sciences, 1997, Volume: 145, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Isoxazoles; Male; Phenobarbital; Time Factors; Valproic Acid; Zonisamide	1997
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione. Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:2 Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid	1998
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation. Neurology, 1999, Mar-10, Volume: 52, Issue:4 Topics: Analysis of Variance; Animals; Female; Folic Acid; Gestational Age; Homocysteine; Methionine; Methylation; Rats; Rats, Wistar; Valproic Acid	1999
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia, 1999, Volume: 40, Issue:3 Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency	1999
Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate. Seizure, 1999, Volume: 8, Issue:4 Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Folic Acid; Humans; Infant, Newborn; Male; Neural Tube Defects; Pregnancy; Pregnancy Complications; Risk; Treatment Failure; Valproic Acid	1999
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta neurologica Scandinavica, 2000, Volume: 101, Issue:4 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12	2000
Genetic basis of susceptibility to environmentally induced neural tube defects. Annals of the New York Academy of Sciences, 2000, Volume: 919 Topics: Animals; Carrier Proteins; Cell Cycle; Disease Models, Animal; DNA Fingerprinting; Embryonic and Fetal Development; Environmental Pollutants; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Predisposition to Disease; Gestational Age; Growth Substances; Humans; Hyperthermia, Induced; Mice; Mice, Knockout; Neural Tube Defects; Polymorphism, Single-Stranded Conformational; Receptors, Cell Surface; Valproic Acid	2000
Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2000, Volume: 4, Issue:6 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Valproic Acid	2000
Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. European journal of pediatrics, 2001, Volume: 160, Issue:5 Topics: Adolescent; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Calcinosis; Celiac Disease; Epilepsy; Ethosuximide; Folic Acid; Humans; Lupus Erythematosus, Systemic; Male; Urea; Valproic Acid	2001
Protocols for identifying drug-nutrient interactions in patients: the role of the dietitian. Journal of the American Dietetic Association, 2002, Volume: 102, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Biotin; Calcium; Carnitine; Dietetics; Edema; Folic Acid; Food-Drug Interactions; Humans; Middle Aged; Seizures; Serum Albumin; Valproic Acid; Weight Gain	2002
Acute valproate administration impairs methionine metabolism in rats. The Journal of nutrition, 2002, Volume: 132, Issue:9 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6	2002
Serum lipids, vitamin B12 and folic acid levels in children receiving long-term valproate therapy. Acta neurologica Belgica, 2002, Volume: 102, Issue:3 Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Humans; Infant; Lipids; Male; Valproic Acid; Vitamin B 12	2002
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid. Brain & development, 2003, Volume: 25, Issue:2 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Valproic Acid; Vitamin B 12	2003
Major malformations in offspring of women with epilepsy. Neurology, 2003, Feb-25, Volume: 60, Issue:4 Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Comorbidity; Educational Status; Epilepsy; Female; Finland; Folic Acid; Follow-Up Studies; Humans; Incidence; Logistic Models; Odds Ratio; Oxcarbazepine; Pregnancy; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Prevalence; Prospective Studies; Risk Factors; Valproic Acid	2003
Amelioration of sodium valproate-induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation. Congenital anomalies, 2003, Volume: 43, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Brain; Dietary Supplements; Disease Models, Animal; Enzyme Inhibitors; Female; Folic Acid; Maternal Exposure; Mice; Neural Tube Defects; Time Factors; Valproic Acid; Vitamin B 12	2003
Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice. Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carrier Proteins; Diet; Disease Models, Animal; Embryo Loss; Female; Folate Receptors, GPI-Anchored; Folic Acid; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neural Tube Defects; Pregnancy; Receptors, Cell Surface; Valproic Acid	2003
Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. Epilepsy research, 2005, Volume: 64, Issue:3 Topics: Adult; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Male; Middle Aged; Triazines; Valproic Acid; Vitamin B 12	2005
Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicology and applied pharmacology, 2006, Mar-01, Volume: 211, Issue:2 Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Dose-Response Relationship, Drug; Female; Fetal Diseases; Folic Acid; Gestational Age; Immunoblotting; Injections, Subcutaneous; Male; Mice; Neural Tube Defects; NF-kappa B; Pantothenic Acid; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myb; Proto-Oncogene Proteins c-pim-1; Tumor Suppressor Protein p53; Valproic Acid; Vitamin B Complex	2006
Macrocytosis associated with divalproex treatment. Journal of child and adolescent psychopharmacology, 2005, Volume: 15, Issue:6 Topics: Anemia, Macrocytic; Anticonvulsants; Bipolar Disorder; Child; Dose-Response Relationship, Drug; Erythrocyte Indices; Female; Folic Acid; Follow-Up Studies; Humans; Platelet Count; Thrombocytopenia; Valproic Acid; Vitamin B 12	2005
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6. Seizure, 2006, Volume: 15, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Pyridoxal Phosphate; Reference Values; Valproic Acid; Vitamin B 12	2006
Ultrastructural investigation of the protective role of folic acid and vitamin E against toxic effects of valproic acid on maternal liver tissue during period of gestation. Saudi medical journal, 2006, Volume: 27, Issue:3 Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Injections, Subcutaneous; Liver; Pregnancy; Rats; Rats, Wistar; Valproic Acid; Vitamin E; Vitamins	2006
The effects of valproic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal period. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2006, Volume: 188, Issue:2 Topics: Animals; Bone and Bones; Female; Fetal Development; Folic Acid; Models, Animal; Pregnancy; Rats; Rats, Wistar; Ribs; Teratogens; Valproic Acid; Vitamin E	2006
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. European journal of nutrition, 2006, Volume: 45, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12	2006
A case of pancytopenia. Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:5 Topics: Adult; Anticonvulsants; Folic Acid; Humans; Male; Pancytopenia; Schizophrenia; Schizophrenic Psychology; Valproic Acid; Vitamin B 12	2006
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy. Epilepsy research, 2006, Volume: 71, Issue:2-3 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Pyridoxal Phosphate; Valproic Acid; Vitamin B 12	2006
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect. Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1 Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Valproic Acid; Vitamin B 12; Vitamin B 6	2007
Homocysteine levels in epileptic children receiving antiepileptic drugs. Journal of child neurology, 2007, Volume: 22, Issue:12 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Oxcarbazepine; Valproic Acid; Vitamin B 12	2007
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy. Progress in neuro-psychopharmacology & biological psychiatry, 2008, Apr-01, Volume: 32, Issue:3 Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Electrochemistry; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Valproic Acid; Vitamin B 12	2008
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Journal of cellular biochemistry, 2008, Oct-01, Volume: 105, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Brain; Cell Line, Tumor; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Pregnancy; Teratogens; Up-Regulation; Valproic Acid	2008
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. Epilepsy research, 2008, Volume: 82, Issue:1 Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Liver; Male; Methionine; Oxidation-Reduction; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Riboflavin; Valproic Acid; Vitamin B Deficiency	2008
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid". Brain & development, 2009, Volume: 31, Issue:6 Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Arteriosclerosis; Lipid Metabolism Disorders; Risk Factors; Tunica Intima; Valproic Acid	2009
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment? Epilepsy research, 2009, Volume: 87, Issue:1 Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12	2009
Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:8 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Pregnancy; Pregnancy Trimester, First; Risk Factors; Spinal Dysraphism; Valproic Acid	2010
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid. European journal of pediatrics, 2011, Volume: 170, Issue:7 Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex	2011
Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model. Toxicology, 2012, Jan-27, Volume: 291, Issue:1-3 Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Chick Embryo; Chromatography, High Pressure Liquid; Folic Acid; Foot Deformities; Glutathione; Hindlimb; Histone Deacetylases; Homocysteine; Hydrogen Peroxide; Joints; Muscle, Skeletal; Neovascularization, Physiologic; Superoxide Dismutase; Teratogens; Tissue Embedding; Valproic Acid; Vitamins	2012
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis. Epilepsia, 2012, Volume: 53, Issue:1 Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Artery, Common; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Uric Acid; Valproic Acid; Young Adult	2012
Simultaneous folate intake may prevent adverse effect of valproic acid on neurulating nervous system. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Volume: 28, Issue:5 Topics: Animals; Anticonvulsants; Chick Embryo; Embryonic Development; Folic Acid; Nervous System; Neural Tube Defects; Neurulation; Valproic Acid	2012
The ratio of S-adenosylmethione and S-adenosyl-homocysteine is increased in the brains of newborn rats in a model of valproic acid teratogenicity. Toxicology, 2012, Mar-11, Volume: 293, Issue:1-3 Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Folic Acid; Teratogens; Valproic Acid; Vitamins	2012
[Valproic acid pharmacogenetics in an individual approach to treatment of women of childbearing age with epilepsy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 Pt 2 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Fertility; Folic Acid; Folic Acid Deficiency; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Precision Medicine; Valproic Acid; Young Adult	2011
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 Pt 2 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Parturition; Pregnancy; Pregnancy Complications; Valproic Acid	2011
Valproic acid substantially downregulated genes folr1, IGF2R, RGS2, COL6A3, EDNRB, KLF6, and pax-3, N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2013, Volume: 54, Issue:4 Topics: Acetylcysteine; Animals; Avian Proteins; Chick Embryo; Chromatography, High Pressure Liquid; Collagen Type VI; Dose-Response Relationship, Drug; Down-Regulation; Folate Receptor 1; Folic Acid; Gene Expression Regulation, Developmental; Histone Deacetylases; Kruppel-Like Transcription Factors; Models, Biological; Neovascularization, Pathologic; Neural Tube Defects; Oligonucleotide Array Sequence Analysis; Paired Box Transcription Factors; Receptor, IGF Type 2; Receptors, Endothelin; RGS Proteins; Valproic Acid	2013
Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine. Epilepsy research, 2014, Volume: 108, Issue:6 Topics: Adolescent; Anticonvulsants; Aorta; Blood Glucose; Brachial Artery; Carbamazepine; Carotid Arteries; Cholesterol; Cholesterol, HDL; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phosphoric Monoester Hydrolases; Risk Factors; Ultrasonography; Valproic Acid; Vitamin B 12	2014
Valproate and folic acid in pregnancy: associations with autism. Developmental medicine and child neurology, 2014, Volume: 56, Issue:7 Topics: Autistic Disorder; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid	2014
Brief report novel mechanism for valproate-induced teratogenicity. Birth defects research. Part A, Clinical and molecular teratology, 2014, Volume: 100, Issue:8 Topics: Abnormalities, Drug-Induced; Biological Availability; Cell Line; Embryonic Development; Female; Folate Receptors, GPI-Anchored; Folic Acid; HEK293 Cells; Humans; Neural Tube Defects; Pregnancy; Protein Binding; Teratogens; Valproic Acid; Vitamin B Complex	2014
The Phosphorylation State of GSK3β Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration. Cardiovascular toxicology, 2016, Volume: 16, Issue:1 Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Bradycardia; Cell Proliferation; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Female; Folic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Defects, Congenital; Heart Ventricles; Male; Myocytes, Cardiac; Phosphorylation; Serine; Valproic Acid; Vitamins; Zebrafish	2016
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. PloS one, 2015, Volume: 10, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Cross-Sectional Studies; DNA Methylation; Epilepsy; Female; Folic Acid; Heterocyclic Compounds; Homocysteine; Humans; Lamotrigine; Long Interspersed Nucleotide Elements; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Triazines; Valproic Acid; Vitamin B 12; Young Adult	2015
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children. Clinical laboratory, 2015, Volume: 61, Issue:8 Topics: Adolescent; Age Factors; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Time Factors; Treatment Outcome; Valproic Acid; Vitamin B 12	2015
Prescribing trends for sodium valproate in Ireland. Seizure, 2016, Volume: 36 Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Folic Acid; Humans; Ireland; Pregnancy; Retrospective Studies; Valproic Acid; Vitamin B Complex; Young Adult	2016
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects. Birth defects research, 2017, 01-30, Volume: 109, Issue:2 Topics: Amino Acids; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Lipids; Male; Metabolome; Mice; Neural Tube; Neural Tube Defects; Neurulation; Penetrance; Pregnancy; Purines; Pyrimidines; Teratogens; Valproic Acid	2017
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity. Seizure, 2017, Volume: 46 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Astrocytes; Cell Count; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Female; Folic Acid; Hippocampus; Homocysteine; Liver; Male; Neurogenesis; Neurons; Organ Size; Rats, Wistar; Valproic Acid	2017
Effect of valproic acid administration during pregnancy on postnatal development of cerebellar cortex and the possible protective role of folic acid. Folia morphologica, 2018, Volume: 77, Issue:2 Topics: Animals; Anticonvulsants; Cerebellar Cortex; Female; Folic Acid; Maternal Exposure; Pregnancy; Purkinje Cells; Rats; Rats, Sprague-Dawley; Valproic Acid	2018
Fetal Valproate Syndrome - Still a Problem Today! Zeitschrift fur Geburtshilfe und Neonatologie, 2017, Volume: 221, Issue:5 Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Epilepsy; Female; Folic Acid; Humans; Infant, Newborn; Infant, Premature, Diseases; Lamotrigine; Male; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Risk Factors; Syndrome; Valproic Acid	2017
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. Journal of clinical psychopharmacology, 2018, Volume: 38, Issue:1 Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Folic Acid; Humans; Lamotrigine; Neural Tube Defects; Pregnancy; Pregnancy Complications; Spinal Dysraphism; Triazines; Valproic Acid	2018
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells. Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 48 Topics: Adult; Anticonvulsants; Cell Line, Tumor; Cell Survival; Choriocarcinoma; Female; Folate Receptor 1; Folic Acid; Humans; Neoplasms; Placenta Diseases; Pregnancy; Proton-Coupled Folate Transporter; Valproic Acid	2018
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice. Food & function, 2018, May-23, Volume: 9, Issue:5 Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic Acid; Homocysteine; Humans; Male; Mice; Mice, Inbred ICR; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid	2018
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Seizures; Severity of Illness Index; Treatment Outcome; Valproic Acid; Vitamin B 6; Young Adult	2018
Failures in reproductive health policy: overcoming the consequences and causes of inaction. Journal of public health (Oxford, England), 2019, 06-01, Volume: 41, Issue:2 Topics: Female; Fetal Alcohol Spectrum Disorders; Flour; Folic Acid; Food, Fortified; Health Policy; Humans; Informed Consent; Neural Tube Defects; Pregnancy; Reproductive Health; Teratogens; United Kingdom; Valproic Acid	2019
3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis. Chemosphere, 2019, Volume: 227 Topics: Animals; Biological Assay; Cardiotoxicity; Diagnostic Imaging; Embryo, Nonmammalian; Embryonic Development; Folic Acid; Heart Defects, Congenital; Intravital Microscopy; Myocytes, Cardiac; Valproic Acid; Zebrafish	2019
Chronic valproate treatment influences folliculogenesis and reproductive hormones with possible ameliorating role for folic acid in adult albino rats. Acta histochemica, 2019, Volume: 121, Issue:7 Topics: Animals; Female; Folic Acid; Gonadal Steroid Hormones; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Transforming Growth Factor beta1; Valproic Acid	2019
Valproic acid effect on neural tube defects is not prevented by concomitant folic acid supplementation: Early chick embryo model pilot study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2019, Volume: 78 Topics: Animals; Anticonvulsants; Chick Embryo; Female; Folic Acid; Neural Tube Defects; Pilot Projects; Valproic Acid	2019
Classifying by cause and preventing the many causes of spina bifida and anencephaly. Pediatric research, 2020, Volume: 87, Issue:2 Topics: Anencephaly; Anticonvulsants; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Protective Factors; Risk Assessment; Risk Factors; Spinal Dysraphism; Valproic Acid	2020
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. Epilepsy research, 2020, Volume: 159 Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenytoin; Pregnancy; Pregnancy Complications; Registries; Seizures; Topiramate; Valproic Acid	2020
Folic acid dose, valproate, and fetal malformations. Epilepsy & behavior : E&B, 2021, Volume: 114, Issue:Pt A Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Female; Folic Acid; Humans; Pregnancy; Pregnancy Complications; Valproic Acid	2021
Antiseizure medications and fetal nutrients: Effects on choline transporters in a human placental cell line. Epilepsia, 2021, Volume: 62, Issue:6 Topics: Adult; Anticonvulsants; Antigens, CD; Cell Line; Choline; Female; Fetus; Folic Acid; Gene Expression Regulation; Humans; Levetiracetam; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Networks and Pathways; Nutrients; Organic Cation Transport Proteins; Placenta; Pregnancy; Valproic Acid	2021
Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food & function, 2021, May-21, Volume: 12, Issue:10 Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Social Behavior; Valproic Acid	2021
Folic acid supplementation rescues valproic acid-induced developmental neurotoxicity and behavioral alterations in zebrafish embryos. Epilepsia, 2021, Volume: 62, Issue:7 Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Behavior, Animal; Dietary Supplements; Embryonic Development; Folic Acid; Larva; Lighting; Mesencephalon; Motor Neurons; Neural Stem Cells; Neural Tube Defects; Neurites; Neurotoxicity Syndromes; Rhombencephalon; Valproic Acid; Vitamins; Zebrafish	2021
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats. Drug metabolism and pharmacokinetics, 2021, Volume: 40 Topics: Animals; Anticonvulsants; Female; Folic Acid; Histone Deacetylase Inhibitors; Membrane Transport Proteins; Minor Histocompatibility Antigens; Placenta; Pregnancy; Proton-Coupled Folate Transporter; Rats; Reduced Folate Carrier Protein; Valproic Acid	2021
[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center]. Der Nervenarzt, 2022, Volume: 93, Issue:6 Topics: Anticonvulsants; Counseling; Epilepsy; Female; Folic Acid; Humans; Lamotrigine; Levetiracetam; Outpatients; Pregnancy; Pregnancy Complications; Retrospective Studies; Seizures; Valproic Acid	2022
Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health. Science progress, 2021, Volume: 104, Issue:4 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Folic Acid; Humans; Infant; Nigeria; Public Health; Valproic Acid	2021
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria. Nigerian journal of clinical practice, 2022, Volume: 25, Issue:10 Topics: Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Delivery of Health Care; Epilepsy; Folic Acid; Humans; Nigeria; Phenobarbital; Quality of Life; Valproic Acid	2022