valproic acid and entinostat

valproic acid has been researched along with entinostat in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (31.03)	29.6817
2010's	15 (51.72)	24.3611
2020's	5 (17.24)	2.80

Authors

Authors	Studies
Bitterman, PB; Huo, Y; Mahmud, SA; Slungaard, A; Wang, J	1
Corey, DR; Sakurai, F; Yu, D	1
Brindisi, M; Brogi, S; Butini, S; Campiani, G; Gemma, S; Saraswati, AP	1
Alfano, AI; Barone, S; Brindisi, M; Cassese, E; Summa, V	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Du, GH; Liu, AL; Long, J; Wang, N	1
Schroeder, TM; Westendorf, JJ	1
Blum, W; Marcucci, G	1
Gronemeyer, H; Herbrecht, R; Lieb, M; Lutz, P; Manzo, F; Shankaranarayanan, P; Tsapis, M	1
Ballestrero, A; Beck, J; Brossart, P; Grünebach, F; Nencioni, A; Patrone, F; Werth, D	1
Das, CM; Gopalakrishnan, V; Prasad, P; Vasquez, H; Wolff, JE	1
Slattery, EL; Speck, JD; Warchol, ME	1
Debatin, KM; Dittrich, A; Fulda, S; Häcker, S; Krauss, J; Mohr, A; Rutkowski, S; Schweitzer, T	1
Fricke, A; Mahlknecht, U; Ong, MF; Purrucker, JC; Rübe, C; Rübe, CE	1
Chen, H; Dzitoyeva, S; Manev, H	1
Capogrossi, MC; Castellano, S; Colussi, C; Farsetti, A; Gaetano, C; Illi, B; Mai, A; Mattiussi, S; Rosati, J; Sbardella, G; Scopece, A; Spallotta, F; Vitale, S	1
Činčárová, L; Fajkus, J; Fajkusová, L; Konečná, H; Lochmanová, G; Nováková, K; Šultesová, P; Zdráhal, Z	1
Das, G; Jagtap, JC; Mruthyunjaya, S; Pujari, R; Shah, RD; Shastry, P; Shelke, GV	1
Cassidy, MR; Gainsbury, ML; Heydrick, S; Sheldon, HK; Sherburne, AC; Stucchi, AF	1
Beck, JF; Becker, S; Krämer, OH; Marx, C; Palani, CD; Sonnemann, J; Wittig, S	1
Csernansky, JG; Dong, H; Fang, D; Gallardo, C; Gerst, N; Keegan, J; Matsumoto, M; Montalvo-Ortiz, JL; Tetsuka, K; Tucker, C	1
Ng, YK; Ong, WY; Tan, CS	1
Carter, CA; Day, RM; Lybeck, M; Oronsky, A; Oronsky, B; Oronsky, N; Richard, P; Scicinski, J; Zeman, K	1
Beyer, M; Kiweler, N; Krämer, OH; Mahboobi, S	1
Mahadevan, V; P, HA; R, M	1
Gong, C; Lee, DA; Liu, F; Ni, L; Ni, Z; Wang, L; Watowich, SS; Yan, X; Yao, C; Zhu, S; Zhu, X	1
Csernansky, JG; Dong, H; Fang, D; Fisher, DW; Montalvo-Ortiz, JL; Rodríguez, G	1
Brenner, W; Butter, F; Kiweler, N; Krämer, OH; Mahendrarajah, N; Schneider, G; Stauber, RH; Wirth, M; Wünsch, D	1
Choi, J; Hwang, J; Jang, S; Jeong, HS; Ramalingam, M	1

Reviews

4 review(s) available for valproic acid and entinostat

Article	Year
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology. Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4 Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Histone Deacetylase 6; Humans; Signal Transduction	2022
[A new target of cancer therapy: advances in the study of histone deacetylase]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:7 Topics: Acetylation; Animals; Apoptosis; Benzamides; Drug Delivery Systems; Enzyme Inhibitors; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasms; Peptides; Pyridines; Valproic Acid	2005
Targeting epigenetic changes in acute myeloid leukemia. Clinical advances in hematology & oncology : H&O, 2005, Volume: 3, Issue:11 Topics: Acetylation; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Depsipeptides; DNA Methylation; Drug Delivery Systems; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid; Phenylbutyrates; Pyridines; Valproic Acid	2005
Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies. Oncotarget, 2016, Jun-28, Volume: 7, Issue:26 Topics: Antibodies, Monoclonal; Azacitidine; Azetidines; Benzamides; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; CpG Islands; Disease Progression; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Histones; Humans; Hydralazine; Immunotherapy; Lung Neoplasms; Molecular Targeted Therapy; Mutation; Neoplasm Recurrence, Local; Nitro Compounds; Nivolumab; Prognosis; Pyridines; Treatment Outcome; Valproic Acid	2016

Trials

1 trial(s) available for valproic acid and entinostat

Article	Year
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39 Topics: Acetylation; Cells, Cultured; E-Selectin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipopolysaccharides; Monocytes; NF-kappa B; Protein Binding; Response Elements; RNA, Messenger; RNA, Small Interfering; Thromboplastin; Thrombosis; Transcription, Genetic; Tumor Necrosis Factor-alpha	2007

Article

Year

Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.

The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39

Topics: Acetylation; Cells, Cultured; E-Selectin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipopolysaccharides; Monocytes; NF-kappa B; Protein Binding; Response Elements; RNA, Messenger; RNA, Small Interfering; Thromboplastin; Thrombosis; Transcription, Genetic; Tumor Necrosis Factor-alpha

2007

Other Studies

24 other study(ies) available for valproic acid and entinostat

Article	Year
Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Clone Cells; Epigenesis, Genetic; Fibroblasts; Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2; Molecular Structure; Mutation; Organic Chemicals; Polymerase Chain Reaction; Rett Syndrome; RNA, Messenger; Stereoisomerism	2011
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases. Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1 Topics: Animals; Biomarkers; Cell Line; Epigenesis, Genetic; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Humans; Mice; Protein Processing, Post-Translational; Rare Diseases	2020
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Histone deacetylase inhibitors promote osteoblast maturation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:12 Topics: Acetylation; Alkaline Phosphatase; Animals; Benzamides; Butyric Acid; Calcification, Physiologic; Calcium; Cell Cycle; Cell Differentiation; Cell Line; Cell Shape; Cell Survival; Cells, Cultured; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Integrin-Binding Sialoprotein; Mice; Organ Culture Techniques; Osteoblasts; Osteocalcin; Osteopontin; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Skull; Valproic Acid	2005
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway. The international journal of biochemistry & cell biology, 2007, Volume: 39, Issue:7-8 Topics: Apoptosis; Benzamides; Burkitt Lymphoma; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug Resistance, Neoplasm; Glucocorticoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Leukemia-Lymphoma, Adult T-Cell; Pyridines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Tumor Cells, Cultured; Valproic Acid; Vorinostat	2007
Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jul-01, Volume: 13, Issue:13 Topics: Active Transport, Cell Nucleus; Benzamides; Cell Differentiation; Cell Nucleus; Dendritic Cells; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Immune System; Immunosuppressive Agents; Interferon Regulatory Factor-3; Interferon Regulatory Factors; Monocytes; Pyridines; Transcription Factor RelB; Valproic Acid	2007
Histone acetylation resulting in resistance to methotrexate in choroid plexus cells. Journal of neuro-oncology, 2009, Volume: 91, Issue:3 Topics: Acetylation; Animals; Antigens, Viral, Tumor; Apoptosis; Benzamides; Carcinoma; Cell Line, Transformed; Cell Line, Tumor; Choroid Plexus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Inhibitory Concentration 50; Methotrexate; Mice; Pyridines; Tetrazolium Salts; Thiazoles; Valproic Acid	2009
Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. Journal of the Association for Research in Otolaryngology : JARO, 2009, Volume: 10, Issue:3 Topics: Animals; Apoptosis; Benzamides; Butyrates; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chickens; Epigenesis, Genetic; Epithelium; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Pyridines; Regeneration; Saccule and Utricle; Valproic Acid	2009
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Oncogene, 2009, Sep-03, Volume: 28, Issue:35 Topics: Benzamides; Caspase 8; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Silencing; Heterozygote; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Medulloblastoma; Neoplasms; Pyridines; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Valproic Acid; Vorinostat	2009
HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity. Oncology reports, 2010, Volume: 23, Issue:1 Topics: Benzamides; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; Dose-Response Relationship, Radiation; Fibroblasts; Histone Deacetylases; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Pyridines; Signal Transduction; Sodium Oxybate; Time Factors; Valproic Acid; Vorinostat	2010
Effect of valproic acid on mitochondrial epigenetics. European journal of pharmacology, 2012, Sep-05, Volume: 690, Issue:1-3 Topics: 3T3-L1 Cells; 5-Methylcytosine; Animals; Anticonvulsants; Base Sequence; Benzamides; Cell Nucleus; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA, Mitochondrial; Epigenesis, Genetic; Mice; Mitochondria; Molecular Sequence Data; Pyridines; RNA, Messenger; Valproic Acid	2012
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:10 Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Subcutaneous; Lysine; Male; Models, Animal; Muscle Contraction; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroglycerin; p300-CBP Transcription Factors; Pyridines; Rats; Valproic Acid; Vasodilation	2012
A combined approach for the study of histone deacetylase inhibitors. Molecular bioSystems, 2012, Volume: 8, Issue:11 Topics: Acetylation; Benzamides; Cell Line, Tumor; Chromatography, High Pressure Liquid; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Pyridines; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Valproic Acid	2012
Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of cellular biochemistry, 2013, Volume: 114, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; Neuroblastoma; Proteolysis; Proto-Oncogene Proteins c-akt; Pyridines; Staurosporine; Survivin; Valproic Acid	2013
Histone deacetylase inhibitors decrease intra-abdominal adhesions with one intraoperative dose by reducing peritoneal fibrin deposition pathways. Surgery, 2014, Volume: 155, Issue:2 Topics: Animals; Benzamides; Fibrin; Fibrinogen; Histone Deacetylase Inhibitors; Hydroxamic Acids; Intestines; Intraoperative Care; Male; Peritoneum; Pyridines; Rats; Rats, Wistar; Thromboplastin; Tissue Adhesions; Valproic Acid; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vorinostat; Wound Healing	2014
p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors. British journal of cancer, 2014, Feb-04, Volume: 110, Issue:3 Topics: Benzamides; Cell Proliferation; Colonic Neoplasms; Flow Cytometry; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Peptides, Cyclic; Proto-Oncogene Proteins c-mdm2; Pyridines; Tumor Suppressor Protein p53; Valproic Acid; Vorinostat	2014
HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:6 Topics: Acetylation; Aging; Animals; Avoidance Learning; Benzamides; Conditioning, Psychological; Dopamine Antagonists; Genes, fos; Haloperidol; Histone Deacetylase Inhibitors; Histones; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Prefrontal Cortex; Pyridines; Valproic Acid	2014
Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. Molecular neurobiology, 2016, Volume: 53, Issue:6 Topics: Anacardic Acids; Anilides; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Deoxyadenosines; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; L-Lactate Dehydrogenase; Lysine; Neuroblastoma; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thionucleosides; Valproic Acid	2016
How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot. Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1510 Topics: Acetylation; Animals; Benzamides; Blotting, Western; Cell Line, Tumor; Epigenesis, Genetic; Epithelial Cells; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Indoles; Mice; Monocytes; Panobinostat; Protein Processing, Post-Translational; Pyridines; Valproic Acid	2017
HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells. Journal of biomolecular structure & dynamics, 2018, Volume: 36, Issue:4 Topics: Benzamides; Butyric Acid; Cell Survival; Colonic Neoplasms; Computer Simulation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Mutation; Pyridines; Tumor Suppressor Protein p53; Valproic Acid	2018
The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3. Scientific reports, 2017, 03-24, Volume: 7 Topics: Acetylation; Benzamides; Cell Line; Cell Survival; Gene Expression Regulation; Histone Deacetylases; Humans; Killer Cells, Natural; NK Cell Lectin-Like Receptor Subfamily K; Phosphorylation; Pyridines; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Valproic Acid	2017
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. Psychopharmacology, 2017, Volume: 234, Issue:16 Topics: Acetylation; Aging; Animals; Benzamides; Corpus Striatum; Dopamine Antagonists; Haloperidol; Histone Deacetylase Inhibitors; Histones; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pyridines; Valproic Acid	2017
Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. Journal of cancer research and clinical oncology, 2020, Volume: 146, Issue:2 Topics: Animals; Benzamides; Cell Plasticity; Cisplatin; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms; Pyridines; Transforming Growth Factor beta; Valproic Acid	2020
Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway. BMC neuroscience, 2023, 05-01, Volume: 24, Issue:1 Topics: Cell Differentiation; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Neuroblastoma; Neurons; Tretinoin; Valproic Acid; Wnt Signaling Pathway	2023